RADEK SKODA to Mice
This is a "connection" page, showing publications RADEK SKODA has written about Mice.
Connection Strength
1.129
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Loss of Socs2 improves molecular responses to IFNa in a mouse model of myeloproliferative neoplasms driven by JAK2-V617F. Leukemia. 2025 Apr; 39(4):876-887.
Score: 0.070
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Loss of Dnmt3a increases self-renewal and resistance to pegIFN-a in JAK2-V617F-positive myeloproliferative neoplasms. Blood. 2024 06 13; 143(24):2490-2503.
Score: 0.066
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The glutaminase inhibitor CB-839 targets metabolic dependencies of JAK2-mutant hematopoiesis in MPN. Blood Adv. 2024 05 14; 8(9):2312-2325.
Score: 0.066
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IL-1? promotes MPN disease initiation by favoring early clonal expansion of JAK2-mutant hematopoietic stem cells. Blood Adv. 2024 03 12; 8(5):1234-1249.
Score: 0.065
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Iron is a modifier of the phenotypes of JAK2-mutant myeloproliferative neoplasms. Blood. 2023 04 27; 141(17):2127-2140.
Score: 0.061
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Inhibition of interleukin-1? reduces myelofibrosis and osteosclerosis in mice with JAK2-V617F driven myeloproliferative neoplasm. Nat Commun. 2022 09 13; 13(1):5346.
Score: 0.059
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JAK2-V617F and interferon-a induce megakaryocyte-biased stem cells characterized by decreased long-term functionality. Blood. 2021 04 22; 137(16):2139-2151.
Score: 0.053
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Mouse models of myeloproliferative neoplasms for pre-clinical testing of novel therapeutic agents. Biomed Pap Med Fac Univ Palacky Olomouc Czech Repub. 2021 Mar; 165(1):26-33.
Score: 0.052
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JAK2-mutant hematopoietic cells display metabolic alterations that can be targeted to treat myeloproliferative neoplasms. Blood. 2019 11 21; 134(21):1832-1846.
Score: 0.048
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Loss of Ezh2 synergizes with JAK2-V617F in initiating myeloproliferative neoplasms and promoting myelofibrosis. J Exp Med. 2016 07 25; 213(8):1479-96.
Score: 0.038
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JAK2 exon 12 mutant mice display isolated erythrocytosis and changes in iron metabolism favoring increased erythropoiesis. Blood. 2016 08 11; 128(6):839-51.
Score: 0.038
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Deletion of Stat3 in hematopoietic cells enhances thrombocytosis and shortens survival in a JAK2-V617F mouse model of MPN. Blood. 2015 Mar 26; 125(13):2131-40.
Score: 0.034
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Myeloproliferative neoplasms can be initiated from a single hematopoietic stem cell expressing JAK2-V617F. J Exp Med. 2014 Oct 20; 211(11):2213-30.
Score: 0.034
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Loss of Stat1 decreases megakaryopoiesis and favors erythropoiesis in a JAK2-V617F-driven mouse model of MPNs. Blood. 2014 Jun 19; 123(25):3943-50.
Score: 0.033
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Selective deletion of Jak2 in adult mouse hematopoietic cells leads to lethal anemia and thrombocytopenia. Haematologica. 2014 Apr; 99(4):e52-4.
Score: 0.032
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Differential effects of hydroxyurea and INC424 on mutant allele burden and myeloproliferative phenotype in a JAK2-V617F polycythemia vera mouse model. Blood. 2013 Feb 14; 121(7):1188-99.
Score: 0.030
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Thrombocytosis. Hematology Am Soc Hematol Educ Program. 2009; 159-67.
Score: 0.023
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Pronounced thrombocytosis in transgenic mice expressing reduced levels of Mpl in platelets and terminally differentiated megakaryocytes. Blood. 2009 Feb 19; 113(8):1768-77.
Score: 0.022
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Ratio of mutant JAK2-V617F to wild-type Jak2 determines the MPD phenotypes in transgenic mice. Blood. 2008 Apr 15; 111(8):3931-40.
Score: 0.021
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Normal erythropoiesis but severe polyposis and bleeding anemia in Smad4-deficient mice. Blood. 2007 Oct 15; 110(8):3049-55.
Score: 0.020
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Pf4-Cre transgenic mice allow the generation of lineage-restricted gene knockouts for studying megakaryocyte and platelet function in vivo. Blood. 2007 Feb 15; 109(4):1503-6.
Score: 0.019
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Nuclear and cytosolic fractions of SOX2 synergize as transcriptional and translational co-regulators of cell fate. Cell Rep. 2024 10 22; 43(10):114807.
Score: 0.017
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A truncated isoform of c-Mpl with an essential C-terminal peptide targets the full-length receptor for degradation. J Biol Chem. 2004 Aug 27; 279(35):36397-404.
Score: 0.017
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A 2-kb c-mpl promoter fragment is sufficient to direct expression to the megakaryocytic lineage and sites of embryonic hematopoiesis in transgenic mice. Blood. 2002 Aug 01; 100(3):1072-4.
Score: 0.015
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Loss of EZH2 Reprograms BCAA Metabolism to Drive Leukemic Transformation. Cancer Discov. 2019 09; 9(9):1228-1247.
Score: 0.012
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Targeting compensatory MEK/ERK activation increases JAK inhibitor efficacy in myeloproliferative neoplasms. J Clin Invest. 2019 03 04; 129(4):1596-1611.
Score: 0.011
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Permissive role of thrombopoietin and granulocyte colony-stimulating factor receptors in hematopoietic cell fate decisions in vivo. Proc Natl Acad Sci U S A. 1999 Jan 19; 96(2):698-702.
Score: 0.011
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The sympathomimetic agonist mirabegron did not lower JAK2-V617F allele burden, but restored nestin-positive cells and reduced reticulin fibrosis in patients with myeloproliferative neoplasms: results of phase II study SAKK 33/14. Haematologica. 2019 04; 104(4):710-716.
Score: 0.011
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HSP27 is a partner of JAK2-STAT5 and a potential therapeutic target in myelofibrosis. Nat Commun. 2018 04 12; 9(1):1431.
Score: 0.011
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Ruxolitinib-induced defects in DNA repair cause sensitivity to PARP inhibitors in myeloproliferative neoplasms. Blood. 2017 12 28; 130(26):2848-2859.
Score: 0.010
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The leptin receptor activates janus kinase 2 and signals for proliferation in a factor-dependent cell line. Mol Endocrinol. 1997 Apr; 11(4):393-9.
Score: 0.010
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Defective STAT signaling by the leptin receptor in diabetic mice. Proc Natl Acad Sci U S A. 1996 Jun 25; 93(13):6231-5.
Score: 0.010
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Homozygous calreticulin mutations in patients with myelofibrosis lead to acquired myeloperoxidase deficiency. Blood. 2016 06 23; 127(25):3253-9.
Score: 0.009
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Thrombopoietin in thrombocytopenic mice: evidence against regulation at the mRNA level and for a direct regulatory role of platelets. Blood. 1996 Jan 15; 87(2):567-73.
Score: 0.009
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Expression of c-MYC under the control of GATA-1 regulatory sequences causes erythroleukemia in transgenic mice. J Exp Med. 1995 May 01; 181(5):1603-13.
Score: 0.009
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Estrogen signaling selectively induces apoptosis of hematopoietic progenitors and myeloid neoplasms without harming steady-state hematopoiesis. Cell Stem Cell. 2014 Dec 04; 15(6):791-804.
Score: 0.009
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Stalled cerebral capillary blood flow in mouse models of essential thrombocythemia and polycythemia vera revealed by in vivo two-photon imaging. J Thromb Haemost. 2014 Dec; 12(12):2120-30.
Score: 0.008
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Haemorrhagic and thrombotic diatheses in mouse models with thrombocytosis. Thromb Haemost. 2015 Feb; 113(2):414-25.
Score: 0.008
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Neuropathy of haematopoietic stem cell niche is essential for myeloproliferative neoplasms. Nature. 2014 Aug 07; 512(7512):78-81.
Score: 0.008
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Murine c-mpl: a member of the hematopoietic growth factor receptor superfamily that transduces a proliferative signal. EMBO J. 1993 Jul; 12(7):2645-53.
Score: 0.008
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The DEAH-box helicase RHAU is an essential gene and critical for mouse hematopoiesis. Blood. 2012 May 03; 119(18):4291-300.
Score: 0.007
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Biphasic roles for soluble guanylyl cyclase (sGC) in platelet activation. Blood. 2011 Sep 29; 118(13):3670-9.
Score: 0.007
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SCL-mediated regulation of the cell-cycle regulator p21 is critical for murine megakaryopoiesis. Blood. 2011 Jul 21; 118(3):723-35.
Score: 0.007
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Platelets regulate lymphatic vascular development through CLEC-2-SLP-76 signaling. Blood. 2010 Jul 29; 116(4):661-70.
Score: 0.006
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Talin is required for integrin-mediated platelet function in hemostasis and thrombosis. J Exp Med. 2007 Dec 24; 204(13):3103-11.
Score: 0.005
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Megakaryocyte-restricted MYH9 inactivation dramatically affects hemostasis while preserving platelet aggregation and secretion. Blood. 2007 Nov 01; 110(9):3183-91.
Score: 0.005
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Expression of LIF in transgenic mice results in altered thymic epithelium and apparent interconversion of thymic and lymph node morphologies. EMBO J. 1994 Mar 15; 13(6):1375-85.
Score: 0.002