DEBORAHJOHNSONDEBORAH JOHNSON7118JOHNSON, DEBORAHProfessor Emeritusprns:coAuthorOfcoauthor ofprns:endDateend dateFaculty Rankprns:fullNamefull nameprns:grantAwardedBygrant awarded byprns:hasAuthorListauthor listprns:hasFacultyRankhas faculty rankprns:hasNetworkhas networkprns:hasPublicationVenuepublished inprns:informationResourceReferenceinformation resource referenceprns:isPrimaryPositionis primary positionprns:latitudelatitudeprns:longitudelongitudeprns:mainImagephotoprns:maxWeightmaximum weightprns:medlineTAjournal title abbreviationprns:meshDescriptorUIMeSH DescriptorUIprns:meshSemanticGroupNameMeSH semantic group nameprns:minWeightminimum weightprns:numberOfAuthorsnumber of authorsprns:numberOfConnectionsnumber of connectionsprns:numberOfPublicationsnumber of publicationsprns:personIdPerson IDprns:personInPrimaryPositionperson in primary positionprns:positionInDepartmentposition in departmentprns:positionInDivisionposition in divisionprns:predicateNodepredicate nodeprns:principalInvestigatorNameprincipal investigator nameprns:publicationDatepublication dateprns:similarTosimilar toprns:sortOrdersort orderprns:startDatestart dateprns:uniquenessWeightuniqueness weightprns:yearyearAcademic ArticleArticleDocumentbibo:pmidPubMed IdentifierAddressvivo:address1address line 1vivo:addressCitycityvivo:addressPostalCodepostal codevivo:addressStatestate or provinceAgreementvivo:authorInAuthorshipselected publicationsvivo:authorRankauthor rank in publicationAuthorshipDepartmentDivisionGrantvivo:hasResearchArearesearch areasvivo:hasResearcherRoleresearch activitiesvivo:hrJobTitleHR job titleInformation Resourcevivo:linkedAuthorlinked authorvivo:linkedInformationResourcelinked information resourcevivo:mailingAddressmailing addressvivo:personInPositionpositionsPositionvivo:positionInOrganizationposition in organizationvivo:preferredTitlepreferred titleResearcher Rolevivo:researcherRoleOfresearcher role ofRolevivo:roleContributesTocontributes tovivo:sponsorAwardIdsponsor award idrdf:predicatepredicaterdf:typetyperdfs:labellabelConceptAgentfoaf:firstNamefirst namefoaf:lastNamelast nameOrganizationPerson25502566Palian BM, Rohira AD, Johnson SA, He L, Zheng N, Dubeau L, Stiles BL, Johnson DLPLoS geneticsMaf1 is a novel target of PTEN and PI3K signaling that negatively regulates oncogenesis and lipid metabolism. PLoS Genet. 2014 Dec; 10(12):e1004789.PLoS Genet2014-12-11T00:00:002014Maf1 is a novel target of PTEN and PI3K signaling that negatively regulates oncogenesis and lipid metabolism.Authorship 1586988Authorship 1586991Authorship 158700125497095Khanna A, Johnson DL, Curran SPCell reportsPhysiological roles for mafr-1 in reproduction and lipid homeostasis. Cell Rep. 2014 Dec 24; 9(6):2180-91.Cell Rep2014-12-11T00:00:002014Physiological roles for mafr-1 in reproduction and lipid homeostasis.18436765Johnson DL, Johnson SAScience (New York, N.Y.)Cell biology. RNA metabolism and oncogenesis. Science. 2008 Apr 25; 320(5875):461-2.Science2008-04-25T00:00:002008Cell biology. RNA metabolism and oncogenesis.Cancer BiologyGynecological Oncology & Reproductive MedicineMolecular & Cellular OncologySystems BiologyMD AndersonMIEN-CHIEHUNGMIEN-CHIE HUNG8427HUNG, MIEN-CHIEProfessorGORDON BMILLSGORDON B MILLS8620MILLS, GORDON BProfessorRONALD ADEPINHORONALD A DEPINHO9729DEPINHO, RONALD AProfessorANIL KSOODANIL K SOOD9048SOOD, ANIL KProfessor74Professor14Associate Professor78Professor Emeritus47Distinguished Service ProfessorAuthorship 327514127296319Johnson DL, Stiles BLTrends in endocrinology and metabolism: TEMMaf1, A New PTEN Target Linking RNA and Lipid Metabolism. Trends Endocrinol Metab. 2016 10; 27(10):742-750.Trends Endocrinol Metab2016-06-10T00:00:002016Maf1, A New PTEN Target Linking RNA and Lipid Metabolism.Authorship 869145628415573Johnson SAS, Lin JJ, Walkey CJ, Leathers MP, Coarfa C, Johnson DLOncotargetElevated TATA-binding protein expression drives vascular endothelial growth factor expression in colon cancer. Oncotarget. 2017 Jul 25; 8(30):48832-48845.Oncotarget2017-07-25T00:00:002017Elevated TATA-binding protein expression drives vascular endothelial growth factor expression in colon cancer.D012320Chemicals & Drugs17490.96734RNA Polymerase IIID035361Chemicals & Drugs3170.992095Transcription Factor TFIIIBD014158Physiology90931650.53903Transcription, GeneticD012097Chemicals & Drugs69016630.553306Repressor Proteins2019-03-31NIHJOHNSON, DEBORAH L.2004-07-01Novel targets that are deregulated by loss of PTENR01CA1086141995-06-30NIHJOHNSON, DEBORAH1991-07-06REGULATION OF DROSOPHILA RNA POLYMERSE I AND IIIR01GM0452992017-06-30NIHJOHNSON, DEBORAH L.1997-05-10Maf1, a novel negative transcriptional regulator of the TATA binding proteinR01CA0741381994-06-30NIHJOHNSON, DEBORAH1988-07-01CHARACTERIZATION OF THE DNA BINDING FUNCTIONR29GM040623Principal InvestigatorPrincipal InvestigatorPrincipal InvestigatorPrincipal InvestigatorD035181Chemicals & Drugs17380.977368TATA-Box Binding ProteinDepartment of Molecular & Cellular BiologyMolecular & Cellular BiologyMolecular Physiology & BiophysicsBaylor College of MedicineCRISTIANCOARFACRISTIAN COARFA0.000000000000000.000000000000001149COARFA, CRISTIANAssociate ProfessorBERTO'MALLEYBERT O'MALLEY0.000000000000000.000000000000002464O'MALLEY, BERTDistinguished Service Professortrue1Distinguished Service ProfessorDistinguished Service ProfessorCHRISTOPHERWALKEYCHRISTOPHER WALKEY15266WALKEY, CHRISTOPHERInstructortrue1Associate ProfessorAssociate Professor23673667Rohira AD, Chen CY, Allen JR, Johnson DLThe Journal of biological chemistryCovalent small ubiquitin-like modifier (SUMO) modification of Maf1 protein controls RNA polymerase III-dependent transcription repression. J Biol Chem. 2013 Jun 28; 288(26):19288-95.J Biol Chem2013-05-14T00:00:002013Covalent small ubiquitin-like modifier (SUMO) modification of Maf1 protein controls RNA polymerase III-dependent transcription repression.true1InstructorInstructorDepartment of Integrative Physiologytrue1Professor EmeritusProfessor Emeritustrue1ProfessorProfessortrue1ProfessorProfessortrue1ProfessorProfessortrue1ProfessorProfessorOne Baylor PlazaHouston, 77030TX3.858510.00117632239research areas0.157460.157462coauthor of29.41526.5951160similar to1140selected publicationsAuthorship 1434334Authorship 1434344Authorship 1434352Authorship 1434363Authorship 1434373Authorship 1434387Authorship 1434395Authorship 1434405Authorship 1434413Authorship 1434423Authorship 1434433Authorship 1434444Authorship 1434459Authorship 1434466Authorship 1434474Authorship 1434484Authorship 1434494Authorship 1434504Authorship 1434513Authorship 1434523Authorship 1434535Authorship 1434544Authorship 1434554Authorship 1434562Authorship 1434574Authorship 1434584Authorship 1434593Authorship 1434605Authorship 1434612Authorship 1434624Authorship 1434631Authorship 1434641Authorship 1434651Authorship 1434663Authorship 1434671321106530Zhong S, Machida K, Tsukamoto H, Johnson DLThe Journal of biological chemistryAlcohol induces RNA polymerase III-dependent transcription through c-Jun by co-regulating TATA-binding protein (TBP) and Brf1 expression. J Biol Chem. 2011 Jan 28; 286(4):2393-401.J Biol Chem2010-11-24T00:00:002010Alcohol induces RNA polymerase III-dependent transcription through c-Jun by co-regulating TATA-binding protein (TBP) and Brf1 expression.19620725Zhong S, Johnson DLProceedings of the National Academy of Sciences of the United States of AmericaThe JNKs differentially regulate RNA polymerase III transcription by coordinately modulating the expression of all TFIIIB subunits. Proc Natl Acad Sci U S A. 2009 Aug 04; 106(31):12682-7.Proc Natl Acad Sci U S A2009-07-20T00:00:002009The JNKs differentially regulate RNA polymerase III transcription by coordinately modulating the expression of all TFIIIB subunits.18710943Fromm JA, Johnson SA, Johnson DLMolecular and cellular biologyEpidermal growth factor receptor 1 (EGFR1) and its variant EGFRvIII regulate TATA-binding protein expression through distinct pathways. Mol Cell Biol. 2008 Oct; 28(20):6483-95.Mol Cell Biol2008-08-18T00:00:002008Epidermal growth factor receptor 1 (EGFR1) and its variant EGFRvIII regulate TATA-binding protein expression through distinct pathways.18456653Johnson SA, Dubeau L, Johnson DLThe Journal of biological chemistryEnhanced RNA polymerase III-dependent transcription is required for oncogenic transformation. J Biol Chem. 2008 Jul 11; 283(28):19184-91.J Biol Chem2008-05-01T00:00:002008Enhanced RNA polymerase III-dependent transcription is required for oncogenic transformation.18391023Woiwode A, Johnson SA, Zhong S, Zhang C, Roeder RG, Teichmann M, Johnson DLMolecular and cellular biologyPTEN represses RNA polymerase III-dependent transcription by targeting the TFIIIB complex. Mol Cell Biol. 2008 Jun; 28(12):4204-14.Mol Cell Biol2008-04-07T00:00:002008PTEN represses RNA polymerase III-dependent transcription by targeting the TFIIIB complex.17612402Zhou D, Zhong S, Ye JJ, Quach KM, Johnson DL, Chen SJournal of molecular signalingPNRC is a unique nuclear receptor coactivator that stimulates RNA polymerase III-dependent transcription. J Mol Signal. 2007 Jul 05; 2:5.J Mol Signal2007-07-05T00:00:002007PNRC is a unique nuclear receptor coactivator that stimulates RNA polymerase III-dependent transcription.17499043Johnson SS, Zhang C, Fromm J, Willis IM, Johnson DLMolecular cellMammalian Maf1 is a negative regulator of transcription by all three nuclear RNA polymerases. Mol Cell. 2007 May 11; 26(3):367-79.Mol Cell2007-05-11T00:00:002007Mammalian Maf1 is a negative regulator of transcription by all three nuclear RNA polymerases.17074809Zhong S, Fromm J, Johnson DLMolecular and cellular biologyTBP is differentially regulated by c-Jun N-terminal kinase 1 (JNK1) and JNK2 through Elk-1, controlling c-Jun expression and cell proliferation. Mol Cell Biol. 2007 Jan; 27(1):54-64.Mol Cell Biol2006-10-30T00:00:002006TBP is differentially regulated by c-Jun N-terminal kinase 1 (JNK1) and JNK2 through Elk-1, controlling c-Jun expression and cell proliferation.16055704Zhang C, Comai L, Johnson DLMolecular and cellular biologyPTEN represses RNA Polymerase I transcription by disrupting the SL1 complex. Mol Cell Biol. 2005 Aug; 25(16):6899-911.Mol Cell Biol2005-08-01T00:00:002005PTEN represses RNA Polymerase I transcription by disrupting the SL1 complex.15169879Zhong S, Zhang C, Johnson DLMolecular and cellular biologyEpidermal growth factor enhances cellular TATA binding protein levels and induces RNA polymerase I- and III-dependent gene activity. Mol Cell Biol. 2004 Jun; 24(12):5119-29.Mol Cell Biol2004-06-01T00:00:002004Epidermal growth factor enhances cellular TATA binding protein levels and induces RNA polymerase I- and III-dependent gene activity.12963838Johnson SA, Dubeau L, White RJ, Johnson DLCell cycle (Georgetown, Tex.)The TATA-binding protein as a regulator of cellular transformation. Cell Cycle. 2003 Sep-Oct; 2(5):442-4.Cell Cycle2003-09-01T00:00:002003The TATA-binding protein as a regulator of cellular transformation.12773395Crighton D, Woiwode A, Zhang C, Mandavia N, Morton JP, Warnock LJ, Milner J, White RJ, Johnson DLThe EMBO journalp53 represses RNA polymerase III transcription by targeting TBP and inhibiting promoter occupancy by TFIIIB. EMBO J. 2003 Jun 02; 22(11):2810-20.EMBO J2003-06-02T00:00:002003p53 represses RNA polymerase III transcription by targeting TBP and inhibiting promoter occupancy by TFIIIB.12697807Johnson SA, Dubeau L, Kawalek M, Dervan A, Sch?nthal AH, Dang CV, Johnson DLMolecular and cellular biologyIncreased expression of TATA-binding protein, the central transcription factor, can contribute to oncogenesis. Mol Cell Biol. 2003 May; 23(9):3043-51.Mol Cell Biol2003-05-01T00:00:002003Increased expression of TATA-binding protein, the central transcription factor, can contribute to oncogenesis.12021320Li J, Xu Z, Zheng Y, Johnson DL, Ou JHJournal of virologyRegulation of hepatocyte nuclear factor 1 activity by wild-type and mutant hepatitis B virus X proteins. J Virol. 2002 Jun; 76(12):5875-81.J Virol2002-06-01T00:00:002002Regulation of hepatocyte nuclear factor 1 activity by wild-type and mutant hepatitis B virus X proteins.10913185Modahl LE, Macnaughton TB, Zhu N, Johnson DL, Lai MMMolecular and cellular biologyRNA-Dependent replication and transcription of hepatitis delta virus RNA involve distinct cellular RNA polymerases. Mol Cell Biol. 2000 Aug; 20(16):6030-9.Mol Cell Biol2000-08-01T00:00:002000RNA-Dependent replication and transcription of hepatitis delta virus RNA involve distinct cellular RNA polymerases.10866657Johnson SA, Mandavia N, Wang HD, Johnson DLMolecular and cellular biologyTranscriptional regulation of the TATA-binding protein by Ras cellular signaling. Mol Cell Biol. 2000 Jul; 20(14):5000-9.Mol Cell Biol2000-07-01T00:00:002000Transcriptional regulation of the TATA-binding protein by Ras cellular signaling.10196229Trivedi A, Young LS, Ouyang C, Johnson DL, Sprague KUThe Journal of biological chemistryA TATA element is required for tRNA promoter activity and confers TATA-binding protein responsiveness in Drosophila Schneider-2 cells. J Biol Chem. 1999 Apr 16; 274(16):11369-75.J Biol Chem1999-04-16T00:00:001999A TATA element is required for tRNA promoter activity and confers TATA-binding protein responsiveness in Drosophila Schneider-2 cells.9819395Wang HD, Trivedi A, Johnson DLMolecular and cellular biologyRegulation of RNA polymerase I-dependent promoters by the hepatitis B virus X protein via activated Ras and TATA-binding protein. Mol Cell Biol. 1998 Dec; 18(12):7086-94.Mol Cell Biol1998-12-01T00:00:001998Regulation of RNA polymerase I-dependent promoters by the hepatitis B virus X protein via activated Ras and TATA-binding protein.9372915Wang HD, Trivedi A, Johnson DLMolecular and cellular biologyHepatitis B virus X protein induces RNA polymerase III-dependent gene transcription and increases cellular TATA-binding protein by activating the Ras signaling pathway. Mol Cell Biol. 1997 Dec; 17(12):6838-46.Mol Cell Biol1997-12-01T00:00:001997Hepatitis B virus X protein induces RNA polymerase III-dependent gene transcription and increases cellular TATA-binding protein by activating the Ras signaling pathway.9218440Vilalta A, Trivedi A, Wang Z, Roeder RG, Johnson DLThe Journal of biological chemistryAn RNA polymerase III-defective mutation in TATA-binding protein disrupts its interaction with a transcription factor IIIB subunit in drosophila cells. J Biol Chem. 1997 Jul 18; 272(29):18087-92.J Biol Chem1997-07-18T00:00:001997An RNA polymerase III-defective mutation in TATA-binding protein disrupts its interaction with a transcription factor IIIB subunit in drosophila cells.8943346Trivedi A, Vilalta A, Gopalan S, Johnson DLMolecular and cellular biologyTATA-binding protein is limiting for both TATA-containing and TATA-lacking RNA polymerase III promoters in Drosophila cells. Mol Cell Biol. 1996 Dec; 16(12):6909-16.Mol Cell Biol1996-12-01T00:00:001996TATA-binding protein is limiting for both TATA-containing and TATA-lacking RNA polymerase III promoters in Drosophila cells.8643509Hong H, Kohli K, Trivedi A, Johnson DL, Stallcup MRProceedings of the National Academy of Sciences of the United States of AmericaGRIP1, a novel mouse protein that serves as a transcriptional coactivator in yeast for the hormone binding domains of steroid receptors. Proc Natl Acad Sci U S A. 1996 May 14; 93(10):4948-52.Proc Natl Acad Sci U S A1996-05-14T00:00:001996GRIP1, a novel mouse protein that serves as a transcriptional coactivator in yeast for the hormone binding domains of steroid receptors.8657153Gottesfeld JM, Johnson DL, Nyborg JKMolecular and cellular biologyTranscriptional activation of RNA polymerase III-dependent genes by the human T-cell leukemia virus type 1 tax protein. Mol Cell Biol. 1996 Apr; 16(4):1777-85.Mol Cell Biol1996-04-01T00:00:001996Transcriptional activation of RNA polymerase III-dependent genes by the human T-cell leukemia virus type 1 tax protein.8524237Wang HD, Yuh CH, Dang CV, Johnson DLMolecular and cellular biologyThe hepatitis B virus X protein increases the cellular level of TATA-binding protein, which mediates transactivation of RNA polymerase III genes. Mol Cell Biol. 1995 Dec; 15(12):6720-8.Mol Cell Biol1995-12-01T00:00:001995The hepatitis B virus X protein increases the cellular level of TATA-binding protein, which mediates transactivation of RNA polymerase III genes.7525587Vilalta A, Kickhoefer VA, Rome LH, Johnson DLThe Journal of biological chemistryThe rat vault RNA gene contains a unique RNA polymerase III promoter composed of both external and internal elements that function synergistically. J Biol Chem. 1994 Nov 25; 269(47):29752-9.J Biol Chem1994-11-25T00:00:001994The rat vault RNA gene contains a unique RNA polymerase III promoter composed of both external and internal elements that function synergistically.8264601Garber ME, Vilalta A, Johnson DLMolecular and cellular biologyInduction of Drosophila RNA polymerase III gene expression by the phorbol ester 12-O-tetradecanoylphorbol-13-acetate (TPA) is mediated by transcription factor IIIB. Mol Cell Biol. 1994 Jan; 14(1):339-47.Mol Cell Biol1994-01-01T00:00:001994Induction of Drosophila RNA polymerase III gene expression by the phorbol ester 12-O-tetradecanoylphorbol-13-acetate (TPA) is mediated by transcription factor IIIB.7681830Kickhoefer VA, Searles RP, Kedersha NL, Garber ME, Johnson DL, Rome LHThe Journal of biological chemistryVault ribonucleoprotein particles from rat and bullfrog contain a related small RNA that is transcribed by RNA polymerase III. J Biol Chem. 1993 Apr 15; 268(11):7868-73.J Biol Chem1993-04-15T00:00:001993Vault ribonucleoprotein particles from rat and bullfrog contain a related small RNA that is transcribed by RNA polymerase III.1545826Reynolds WF, Johnson DLMolecular and cellular biologyDifferential expression of oocyte-type class III genes with fraction TFIIIC from immature or mature oocytes. Mol Cell Biol. 1992 Mar; 12(3):946-53.Mol Cell Biol1992-03-01T00:00:001992Differential expression of oocyte-type class III genes with fraction TFIIIC from immature or mature oocytes.1939109Garber M, Panchanathan S, Fan RS, Johnson DLThe Journal of biological chemistryThe phorbol ester, 12-O-tetradecanoylphorbol-13-acetate, induces specific transcription by RNA polymerase III in Drosophila Schneider cells. J Biol Chem. 1991 Nov 05; 266(31):20598-601.J Biol Chem1991-11-05T00:00:001991The phorbol ester, 12-O-tetradecanoylphorbol-13-acetate, induces specific transcription by RNA polymerase III in Drosophila Schneider cells.1874746Johnson DL, Fan RS, Treinies MLThe Journal of biological chemistryAnalysis of the molecular mechanisms for the species-specific transcription of Drosophila and human tRNA gene transcription components. J Biol Chem. 1991 Aug 25; 266(24):16037-43.J Biol Chem1991-08-25T00:00:001991Analysis of the molecular mechanisms for the species-specific transcription of Drosophila and human tRNA gene transcription components.2808421Johnson DL, Nichols M, Bolger MB, Wilson SThe Journal of biological chemistryInteraction of yeast transcription factor IIIC with dimeric Schizosaccharomyces pombe tRNA(Ser)-tRNA(Met) genes. J Biol Chem. 1989 Nov 15; 264(32):19221-7.J Biol Chem1989-11-15T00:00:001989Interaction of yeast transcription factor IIIC with dimeric Schizosaccharomyces pombe tRNA(Ser)-tRNA(Met) genes.2664466Johnson DL, Wilson SLMolecular and cellular biologyIdentification of a 150-kilodalton polypeptide that copurifies with yeast TFIIIC and binds specifically to tRNA genes. Mol Cell Biol. 1989 May; 9(5):2018-24.Mol Cell Biol1989-05-01T00:00:001989Identification of a 150-kilodalton polypeptide that copurifies with yeast TFIIIC and binds specifically to tRNA genes.7166550DeFranco D, Dingermann T, Johnson DL, Sharp S, S?ll DPrincess Takamatsu symposiaEukaryotic tRNA gene transcription is controlled by signals within and outside the mature coding sequence. Princess Takamatsu Symp. 1982; 12:63-72.Princess Takamatsu Symp1982-01-01T00:00:001982Eukaryotic tRNA gene transcription is controlled by signals within and outside the mature coding sequence.23826727Zeng N, Yang KT, Bayan JA, He L, Aggarwal R, Stiles JW, Hou X, Medina V, Abad D, Palian BM, Al-Abdullah I, Kandeel F, Johnson DL, Stiles BLAging cellPTEN controls ?-cell regeneration in aged mice by regulating cell cycle inhibitor p16ink4a. Aging Cell. 2013 Dec; 12(6):1000-11.Aging Cell2013-08-06T00:00:002013PTEN controls ?-cell regeneration in aged mice by regulating cell cycle inhibitor p16ink4a.