KOENVENKENKOEN VENKEN0.000000000000000.000000000000005734VENKEN, KOENAssistant Professorplugins:TwitterTwitterprns:coAuthorOfcoauthor ofprns:endDateend dateFaculty Rankprns:fullNamefull nameprns:grantAwardedBygrant awarded byprns:hasAuthorListauthor listprns:hasFacultyRankhas faculty rankprns:hasNetworkhas networkprns:hasPublicationVenuepublished inprns:informationResourceReferenceinformation resource referenceprns:isPrimaryPositionis primary positionprns:latitudelatitudeprns:longitudelongitudeprns:mainImagephotoprns:maxWeightmaximum weightprns:medlineTAjournal title abbreviationprns:meshDescriptorUIMeSH DescriptorUIprns:meshSemanticGroupNameMeSH semantic group nameprns:minWeightminimum weightprns:numberOfAuthorsnumber of authorsprns:numberOfConnectionsnumber of connectionsprns:numberOfPublicationsnumber of publicationsprns:personIdPerson IDprns:personInPrimaryPositionperson in primary positionprns:physicalNeighborOfphysical neighborprns:pluginSearchableDataProfilesRNS Plugin Searchable Dataprns:positionInDepartmentposition in departmentprns:positionInDivisionposition in divisionprns:predicateNodepredicate nodeprns:principalInvestigatorNameprincipal investigator nameprns:publicationDatepublication dateprns:similarTosimilar toprns:sortOrdersort orderprns:startDatestart dateprns:uniquenessWeightuniqueness weightprns:yearyearAcademic ArticleArticleDocumentbibo:pmidPubMed IdentifierAddressvivo:address1address line 1vivo:addressCitycityvivo:addressPostalCodepostal codevivo:addressStatestate or provinceAgreementvivo:authorInAuthorshipselected publicationsvivo:authorRankauthor rank in publicationAuthorshipDepartmentDivisionGrantvivo:hasResearchArearesearch areasvivo:hasResearcherRoleresearch activitiesvivo:hrJobTitleHR job titleInformation Resourcevivo:linkAnchorTextlink anchor textvivo:linkedAuthorlinked authorvivo:linkedInformationResourcelinked information resourcevivo:mailingAddressmailing addressvivo:personInPositionpositionsPositionvivo:positionInOrganizationposition in organizationvivo:preferredTitlepreferred titleResearcher Rolevivo:researcherRoleOfresearcher role ofRolevivo:roleContributesTocontributes tovivo:sponsorAwardIdsponsor award idURLLinkvivo:webpagewebpagerdf:predicatepredicaterdf:typetyperdfs:labellabelConceptAgentfoaf:firstNamefirst namefoaf:lastNamelast nameOrganizationPersonAuthorship 1608925Authorship 1628011325529377Shahab J, Baratta C, Scuric B, Godt D, Venken KJ, Ringuette MJDevelopmental dynamics : an official publication of the American Association of AnatomistsLoss of SPARC dysregulates basal lamina assembly to disrupt larval fat body homeostasis in Drosophila melanogaster. Dev Dyn. 2015 Apr; 244(4):540-52.Dev Dyn2015-01-24T00:00:002015Loss of SPARC dysregulates basal lamina assembly to disrupt larval fat body homeostasis in Drosophila melanogaster.25824290Nagarkar-Jaiswal S, Lee PT, Campbell ME, Chen K, Anguiano-Zarate S, Gutierrez MC, Busby T, Lin WW, He Y, Schulze KL, Booth BW, Evans-Holm M, Venken KJ, Levis RW, Spradling AC, Hoskins RA, Bellen HJeLifeA library of MiMICs allows tagging of genes and reversible, spatial and temporal knockdown of proteins in Drosophila. Elife. 2015 Mar 31; 4.Elife2015-03-31T00:00:002015A library of MiMICs allows tagging of genes and reversible, spatial and temporal knockdown of proteins in Drosophila.Authorship 195407225712101Gnerer JP, Venken KJ, Dierick HANucleic acids researchGene-specific cell labeling using MiMIC transposons. Nucleic Acids Res. 2015 Apr 30; 43(8):e56.Nucleic Acids Res2015-02-20T00:00:002015Gene-specific cell labeling using MiMIC transposons.Authorship 281125126447401Venken KJ, Sarrion-Perdigones A, Vandeventer PJ, Abel NS, Christiansen AE, Hoffman KLWiley interdisciplinary reviews. Developmental biologyGenome engineering: Drosophila melanogaster and beyond. Wiley Interdiscip Rev Dev Biol. 2016 Mar-Apr; 5(2):233-67.Wiley Interdiscip Rev Dev Biol2015-10-08T00:00:002015Genome engineering: Drosophila melanogaster and beyond.74Professor10Assistant Professor14Associate Professor6Adjunct Professor47Distinguished Service Professor16230531Shroyer NF, Wallis D, Venken KJ, Bellen HJ, Zoghbi HYGenes & developmentGfi1 functions downstream of Math1 to control intestinal secretory cell subtype allocation and differentiation. Genes Dev. 2005 Oct 15; 19(20):2412-7.Genes Dev2005-10-15T00:00:002005Gfi1 functions downstream of Math1 to control intestinal secretory cell subtype allocation and differentiation.Authorship 323285127107508Venken K, Elewaut DBest practice & research. Clinical rheumatologyNew immune cells in spondyloarthritis: Key players or innocent bystanders? Best Pract Res Clin Rheumatol. 2015 12; 29(6):706-14.Best Pract Res Clin Rheumatol2016-03-12T00:00:002016New immune cells in spondyloarthritis: Key players or innocent bystanders?Authorship 325810326895468Favreau M, Vanderkerken K, Elewaut D, Venken K, Menu EOncotargetDoes an NKT-cell-based immunotherapeutic approach have a future in multiple myeloma? Oncotarget. 2016 Apr 26; 7(17):23128-40.Oncotarget2016-04-26T00:00:002016Does an NKT-cell-based immunotherapeutic approach have a future in multiple myeloma?17620409Koh TW, Korolchuk VI, Wairkar YP, Jiao W, Evergren E, Pan H, Zhou Y, Venken KJ, Shupliakov O, Robinson IM, O'Kane CJ, Bellen HJThe Journal of cell biologyEps15 and Dap160 control synaptic vesicle membrane retrieval and synapse development. J Cell Biol. 2007 Jul 16; 178(2):309-22.J Cell Biol2007-07-09T00:00:002007Eps15 and Dap160 control synaptic vesicle membrane retrieval and synapse development.15466176Kazanjian A, Wallis D, Au N, Nigam R, Venken KJ, Cagle PT, Dickey BF, Bellen HJ, Gilks CB, Grimes HLCancer researchGrowth factor independence-1 is expressed in primary human neuroendocrine lung carcinomas and mediates the differentiation of murine pulmonary neuroendocrine cells. Cancer Res. 2004 Oct 01; 64(19):6874-82.Cancer Res2004-10-01T00:00:002004Growth factor independence-1 is expressed in primary human neuroendocrine lung carcinomas and mediates the differentiation of murine pulmonary neuroendocrine cells.NELEHAELTERMANNELE HAELTERMAN0.000000000000000.000000000000005130HAELTERMAN, NELEAssistant ProfessorKRISTENKARLINKRISTEN KARLIN0.000000000000000.000000000000004913KARLIN, KRISTENAssistant Professor19465919Venken KJ, Carlson JW, Schulze KL, Pan H, He Y, Spokony R, Wan KH, Koriabine M, de Jong PJ, White KP, Bellen HJ, Hoskins RANature methodsVersatile P[acman] BAC libraries for transgenesis studies in Drosophila melanogaster. Nat Methods. 2009 Jun; 6(6):431-4.Nat Methods2009-06-01T00:00:002009Versatile P[acman] BAC libraries for transgenesis studies in Drosophila melanogaster.16055061Verstreken P, Ly CV, Venken KJ, Koh TW, Zhou Y, Bellen HJNeuronSynaptic mitochondria are critical for mobilization of reserve pool vesicles at Drosophila neuromuscular junctions. Neuron. 2005 Aug 04; 47(3):365-78.Neuron2005-08-04T00:00:002005Synaptic mitochondria are critical for mobilization of reserve pool vesicles at Drosophila neuromuscular junctions.Authorship 328255527727248Palmer DJ, Grove NC, Ing J, Crane AM, Venken K, Davis BR, Ng PMolecular therapy. Nucleic acidsHomology Requirements for Efficient, Footprintless Gene Editing at the CFTR Locus in Human iPSCs with Helper-dependent Adenoviral Vectors. Mol Ther Nucleic Acids. 2016 Oct 11; 5(10):e372.Mol Ther Nucleic Acids2016-10-11T00:00:002016Homology Requirements for Efficient, Footprintless Gene Editing at the CFTR Locus in Human iPSCs with Helper-dependent Adenoviral Vectors.15738961Venken KJ, Bellen HJNature reviews. GeneticsEmerging technologies for gene manipulation in Drosophila melanogaster. Nat Rev Genet. 2005 Mar; 6(3):167-78.Nat Rev Genet2005-03-01T00:00:002005Emerging technologies for gene manipulation in Drosophila melanogaster.22017985Venken KJ, Simpson JH, Bellen HJNeuronGenetic manipulation of genes and cells in the nervous system of the fruit fly. Neuron. 2011 Oct 20; 72(2):202-30.Neuron2011-10-20T00:00:002011Genetic manipulation of genes and cells in the nervous system of the fruit fly.16122429Tsuda H, Jafar-Nejad H, Patel AJ, Sun Y, Chen HK, Rose MF, Venken KJ, Botas J, Orr HT, Bellen HJ, Zoghbi HYCellThe AXH domain of Ataxin-1 mediates neurodegeneration through its interaction with Gfi-1/Senseless proteins. Cell. 2005 Aug 26; 122(4):633-44.Cell2005-08-26T00:00:002005The AXH domain of Ataxin-1 mediates neurodegeneration through its interaction with Gfi-1/Senseless proteins.22764224Alves-Silva J, S?nchez-Soriano N, Beaven R, Klein M, Parkin J, Millard TH, Bellen HJ, Venken KJ, Ballestrem C, Kammerer RA, Prokop AThe Journal of neuroscience : the official journal of the Society for NeuroscienceSpectraplakins promote microtubule-mediated axonal growth by functioning as structural microtubule-associated proteins and EB1-dependent +TIPs (tip interacting proteins). J Neurosci. 2012 Jul 04; 32(27):9143-58.J Neurosci2012-07-04T00:00:002012Spectraplakins promote microtubule-mediated axonal growth by functioning as structural microtubule-associated proteins and EB1-dependent +TIPs (tip interacting proteins).17138868Venken KJ, He Y, Hoskins RA, Bellen HJScience (New York, N.Y.)P[acman]: a BAC transgenic platform for targeted insertion of large DNA fragments in D. melanogaster. Science. 2006 Dec 15; 314(5806):1747-51.Science2006-11-30T00:00:002006P[acman]: a BAC transgenic platform for targeted insertion of large DNA fragments in D. melanogaster.23136438Chen YC, Lin YQ, Banerjee S, Venken K, Li J, Ismat A, Chen K, Duraine L, Bellen HJ, Bhat MAThe Journal of neuroscience : the official journal of the Society for NeuroscienceDrosophila neuroligin 2 is required presynaptically and postsynaptically for proper synaptic differentiation and synaptic transmission. J Neurosci. 2012 Nov 07; 32(45):16018-30.J Neurosci2012-11-07T00:00:002012Drosophila neuroligin 2 is required presynaptically and postsynaptically for proper synaptic differentiation and synaptic transmission.19004852Pepple KL, Atkins M, Venken K, Wellnitz K, Harding M, Frankfort B, Mardon GDevelopment (Cambridge, England)Two-step selection of a single R8 photoreceptor: a bistable loop between senseless and rough locks in R8 fate. Development. 2008 Dec; 135(24):4071-9.Development2008-11-12T00:00:002008Two-step selection of a single R8 photoreceptor: a bistable loop between senseless and rough locks in R8 fate.19640479Verstreken P, Ohyama T, Haueter C, Habets RL, Lin YQ, Swan LE, Ly CV, Venken KJ, De Camilli P, Bellen HJNeuronTweek, an evolutionarily conserved protein, is required for synaptic vesicle recycling. Neuron. 2009 Jul 30; 63(2):203-15.Neuron2009-07-30T00:00:002009Tweek, an evolutionarily conserved protein, is required for synaptic vesicle recycling.20876565Venken KJ, Popodi E, Holtzman SL, Schulze KL, Park S, Carlson JW, Hoskins RA, Bellen HJ, Kaufman TCGeneticsA molecularly defined duplication set for the X chromosome of Drosophila melanogaster. Genetics. 2010 Dec; 186(4):1111-25.Genetics2010-09-27T00:00:002010A molecularly defined duplication set for the X chromosome of Drosophila melanogaster.21857973Zheng L, Michelson Y, Freger V, Avraham Z, Venken KJ, Bellen HJ, Justice MJ, Wides RPloS oneDrosophila Ten-m and filamin affect motor neuron growth cone guidance. PLoS One. 2011; 6(8):e22956.PLoS One2011-08-08T00:00:002011Drosophila Ten-m and filamin affect motor neuron growth cone guidance.Authorship 756491422367874Venken KJ, Bellen HJMethods in molecular biology (Clifton, N.J.)Genome-wide manipulations of Drosophila melanogaster with transposons, Flp recombinase, and FC31 integrase. Methods Mol Biol. 2012; 859:203-28.Methods Mol Biol2012-01-01T00:00:002012Genome-wide manipulations of Drosophila melanogaster with transposons, Flp recombinase, and FC31 integrase.28221388Guillaume J, Seki T, Decruy T, Venken K, Elewaut D, Tsuji M, Van Calenbergh SOrganic & biomolecular chemistrySynthesis of C6''-modified a-C-GalCer analogues as mouse and human iNKT cell agonists. Org Biomol Chem. 2017 Mar 08; 15(10):2217-2225.Org Biomol Chem2017-03-08T00:00:002017Synthesis of C6''-modified a-C-GalCer analogues as mouse and human iNKT cell agonists.21177974modENCODE Consortium, Roy S, Ernst J, Kharchenko PV, Kheradpour P, Negre N, Eaton ML, Landolin JM, Bristow CA, Ma L, Lin MF, Washietl S, Arshinoff BI, Ay F, Meyer PE, Robine N, Washington NL, Di Stefano L, Berezikov E, Brown CD, Candeias R, Carlson JW, Carr A, Jungreis I, Marbach D, Sealfon R, Tolstorukov MY, Will S, Alekseyenko AA, Artieri C, Booth BW, Brooks AN, Dai Q, Davis CA, Duff MO, Feng X, Gorchakov AA, Gu T, Henikoff JG, Kapranov P, Li R, MacAlpine HK, Malone J, Minoda A, Nordman J, Okamura K, Perry M, Powell SK, Riddle NC, Sakai A, Samsonova A, Sandler JE, Schwartz YB, Sher N, Spokony R, Sturgill D, van Baren M, Wan KH, Yang L, Yu C, Feingold E, Good P, Guyer M, Lowdon R, Ahmad K, Andrews J, Berger B, Brenner SE, Brent MR, Cherbas L, Elgin SC, Gingeras TR, Grossman R, Hoskins RA, Kaufman TC, Kent W, Kuroda MI, Orr-Weaver T, Perrimon N, Pirrotta V, Posakony JW, Ren B, Russell S, Cherbas P, Graveley BR, Lewis S, Micklem G, Oliver B, Park PJ, Celniker SE, Henikoff S, Karpen GH, Lai EC, MacAlpine DM, Stein LD, White KP, Kellis MScience (New York, N.Y.)Identification of functional elements and regulatory circuits by Drosophila modENCODE. Science. 2010 Dec 24; 330(6012):1787-97.Science2010-12-22T00:00:002010Identification of functional elements and regulatory circuits by Drosophila modENCODE.21430782N?gre N, Brown CD, Ma L, Bristow CA, Miller SW, Wagner U, Kheradpour P, Eaton ML, Loriaux P, Sealfon R, Li Z, Ishii H, Spokony RF, Chen J, Hwang L, Cheng C, Auburn RP, Davis MB, Domanus M, Shah PK, Morrison CA, Zieba J, Suchy S, Senderowicz L, Victorsen A, Bild NA, Grundstad AJ, Hanley D, MacAlpine DM, Mannervik M, Venken K, Bellen H, White R, Gerstein M, Russell S, Grossman RL, Ren B, Posakony JW, Kellis M, White KPNatureA cis-regulatory map of the Drosophila genome. Nature. 2011 Mar 24; 471(7339):527-31.Nature2011-03-24T00:00:002011A cis-regulatory map of the Drosophila genome.22973547Szabad J, Bellen HJ, Venken KJG3 (Bethesda, Md.)An assay to detect in vivo Y chromosome loss in Drosophila wing disc cells. G3 (Bethesda). 2012 Sep; 2(9):1095-102.G3 (Bethesda)2012-09-01T00:00:002012An assay to detect in vivo Y chromosome loss in Drosophila wing disc cells.21985007Venken KJ, Schulze KL, Haelterman NA, Pan H, He Y, Evans-Holm M, Carlson JW, Levis RW, Spradling AC, Hoskins RA, Bellen HJNature methodsMiMIC: a highly versatile transposon insertion resource for engineering Drosophila melanogaster genes. Nat Methods. 2011 Sep; 8(9):737-43.Nat Methods2011-09-01T00:00:002011MiMIC: a highly versatile transposon insertion resource for engineering Drosophila melanogaster genes.22174071Neum?ller RA, Wirtz-Peitz F, Lee S, Kwon Y, Buckner M, Hoskins RA, Venken KJ, Bellen HJ, Mohr SE, Perrimon NGeneticsStringent analysis of gene function and protein-protein interactions using fluorescently tagged genes. Genetics. 2012 Mar; 190(3):931-40.Genetics2011-12-14T00:00:002011Stringent analysis of gene function and protein-protein interactions using fluorescently tagged genes.Authorship 868834128385777Favreau M, Venken K, Faict S, Maes K, De Veirman K, De Bruyne E, Leleu X, Boon L, Elewaut D, Vanderkerken K, Menu EHaematologicaBoth mucosal-associated invariant and natural killer T-cell deficiency in multiple myeloma can be countered by PD-1 inhibition. Haematologica. 2017 07; 102(7):e266-e270.Haematologica2017-04-06T00:00:002017Both mucosal-associated invariant and natural killer T-cell deficiency in multiple myeloma can be countered by PD-1 inhibition.Authorship 873043328626526Janssens J, Decruy T, Venken K, Seki T, Krols S, Van der Eycken J, Tsuji M, Elewaut D, Van Calenbergh SACS medicinal chemistry lettersEfficient Divergent Synthesis of New Immunostimulant 4?-Modified a-Galactosylceramide Analogues. ACS Med Chem Lett. 2017 Jun 08; 8(6):642-647.ACS Med Chem Lett2017-05-05T00:00:002017Efficient Divergent Synthesis of New Immunostimulant 4?-Modified a-Galactosylceramide Analogues.12952864Watase K, Venken KJ, Sun Y, Orr HT, Zoghbi HYHuman molecular geneticsRegional differences of somatic CAG repeat instability do not account for selective neuronal vulnerability in a knock-in mouse model of SCA1. Hum Mol Genet. 2003 Nov 01; 12(21):2789-95.Hum Mol Genet2003-09-02T00:00:002003Regional differences of somatic CAG repeat instability do not account for selective neuronal vulnerability in a knock-in mouse model of SCA1.17905790Venken KJ, Bellen HJDevelopment (Cambridge, England)Transgenesis upgrades for Drosophila melanogaster. Development. 2007 Oct; 134(20):3571-84.Development2007-10-01T00:00:002007Transgenesis upgrades for Drosophila melanogaster.true1Associate ProfessorAssociate Professortrue1Assistant ProfessorAssistant ProfessorD004331Living Beings2158260.623822Drosophila melanogasterD008156Chemicals & Drugs2794440.883736LuciferasesD025241Disorders3100.982718SpondylarthritisAuthorship 9164781Authorship 9166903Authorship 9200162Authorship 9309543Authorship 9362291Authorship 9381785Authorship 939242229858352Gilis E, Mortier C, Venken K, Debusschere K, Vereecke L, Elewaut DThe Journal of rheumatology. SupplementThe Role of the Microbiome in Gut and Joint Inflammation in Psoriatic Arthritis and Spondyloarthritis. J Rheumatol Suppl. 2018 Jun; 94:36-39.J Rheumatol Suppl2018-06-01T00:00:002018The Role of the Microbiome in Gut and Joint Inflammation in Psoriatic Arthritis and Spondyloarthritis.30008717Mortier C, Govindarajan S, Venken K, Elewaut DFrontiers in immunologyIt Takes "Guts" to Cause Joint Inflammation: Role of Innate-Like T Cells. Front Immunol. 2018; 9:1489.Front Immunol2018-06-29T00:00:002018It Takes "Guts" to Cause Joint Inflammation: Role of Innate-Like T Cells.29980684Zhao M, Svensson MND, Venken K, Chawla A, Liang S, Engel I, Mydel P, Day J, Elewaut D, Bottini N, Kronenberg MNature communicationsAltered thymic differentiation and modulation of arthritis by invariant NKT cells expressing mutant ZAP70. Nat Commun. 2018 07 06; 9(1):2627.Nat Commun2018-07-06T00:00:002018Altered thymic differentiation and modulation of arthritis by invariant NKT cells expressing mutant ZAP70.30193839De Bruyne M, Bogaert DJ, Venken K, Van den Bossche L, Bonroy C, Roels L, Tavernier SJ, van de Vijver E, Driessen A, van Gijn M, G?mez-Diaz L, Elewaut D, Grimbacher B, Haerynck F, Moes N, Dullaers MThe Journal of allergy and clinical immunologyA novel LPS-responsive beige-like anchor protein (LRBA) mutation presents with normal cytotoxic T lymphocyte-associated protein 4 (CTLA-4) and overactive TH17 immunity. J Allergy Clin Immunol. 2018 12; 142(6):1968-1971.J Allergy Clin Immunol2018-09-05T00:00:002018A novel LPS-responsive beige-like anchor protein (LRBA) mutation presents with normal cytotoxic T lymphocyte-associated protein 4 (CTLA-4) and overactive TH17 immunity.30153633Venken K, Favreau M, Gaublomme D, Menu E, Vanderkerken K, Elewaut DMolecular immunologyCheckpoint inhibition in the treatment of multiple myeloma: A way to boost innate-like T cell anti-tumor function? Mol Immunol. 2018 09; 101:521-526.Mol Immunol2018-08-25T00:00:002018Checkpoint inhibition in the treatment of multiple myeloma: A way to boost innate-like T cell anti-tumor function?30602780Venken K, Jacques P, Mortier C, Labadia ME, Decruy T, Coudenys J, Hoyt K, Wayne AL, Hughes R, Turner M, Van Gassen S, Martens L, Smith D, Harcken C, Wahle J, Wang CT, Verheugen E, Schryvers N, Varkas G, Cypers H, Wittoek R, Piette Y, Gyselbrecht L, Van Calenbergh S, Van den Bosch F, Saeys Y, Nabozny G, Elewaut DNature communicationsROR?t inhibition selectively targets IL-17 producing iNKT and ?d-T cells enriched in Spondyloarthritis patients. Nat Commun. 2019 01 02; 10(1):9.Nat Commun2019-01-02T00:00:002019ROR?t inhibition selectively targets IL-17 producing iNKT and ?d-T cells enriched in Spondyloarthritis patients.30556652Janssens J, Bitra A, Wang J, Decruy T, Venken K, van der Eycken J, Elewaut D, Zajonc DM, van Calenbergh SChemMedChem4"-O-Alkylated a-Galactosylceramide Analogues as iNKT-Cell Antigens: Synthetic, Biological, and Structural Studies. ChemMedChem. 2019 01 08; 14(1):147-168.ChemMedChem2018-12-17T00:00:0020184"-O-Alkylated a-Galactosylceramide Analogues as iNKT-Cell Antigens: Synthetic, Biological, and Structural Studies.D003001Procedures44712120.822783Cloning, MolecularD055611Anatomy581240.860355Natural Killer T-CellsDepartment of Molecular & Cellular BiologyDepartment of Molecular & Human GeneticsDepartment of Pathology & ImmunologyMolecular & Cellular BiologyMolecular & Human GeneticsPathologyBaylor College of MedicineHERMANDIERICKHERMAN DIERICK29.71073630000000-95.396604500000001369DIERICK, HERMANAssociate ProfessorJINWANGJIN WANG0.000000000000000.000000000000001912WANG, JINProfessorBENIGNOVALDEZBENIGNO VALDEZ0.000000000000000.000000000000003269VALDEZ, BENIGNOAdjunct ProfessorFRANCISTSAIFRANCIS TSAI0.000000000000000.00000000000000256TSAI, FRANCISProfessorRONALDDAVISRONALD DAVIS0.000000000000000.000000000000003208DAVIS, RONALDAdjunct ProfessorGRAEMEMARDONGRAEME MARDON0.000000000000000.000000000000003439MARDON, GRAEMEProfessorHUGOBELLENHUGO BELLEN29.71010310000000-95.397396100000003292BELLEN, HUGODistinguished Service ProfessorGREGOREICHELEGREGOR EICHELE0.000000000000000.000000000000003334EICHELE, GREGORAdjunct ProfessorAuthorship 944572530928902Cambr? I, Gaublomme D, Schryvers N, Lambrecht S, Lories R, Venken K, Elewaut DAnnals of the rheumatic diseasesRunning promotes chronicity of arthritis by local modulation of complement activators and impairing T regulatory feedback loops. Ann Rheum Dis. 2019 06; 78(6):787-795.Ann Rheum Dis2019-03-30T00:00:002019Running promotes chronicity of arthritis by local modulation of complement activators and impairing T regulatory feedback loops.Authorship 950942431259485Gilis E, Gaublomme D, Staal J, Venken K, Dhaenens M, Lambrecht S, Coudenys J, Decruy T, Schryvers N, Driege Y, Dumas E, Demeyer A, De Muynck A, van Hengel J, Van Hoorebeke L, Deforce D, Beyaert R, Elewaut DArthritis & rheumatology (Hoboken, N.J.)Deletion of Mucosa-Associated Lymphoid Tissue Lymphoma Translocation Protein 1 in Mouse T Cells Protects Against Development of Autoimmune Arthritis but Leads to Spontaneous Osteoporosis. Arthritis Rheumatol. 2019 12; 71(12):2005-2015.Arthritis Rheumatol2019-11-09T00:00:002019Deletion of Mucosa-Associated Lymphoid Tissue Lymphoma Translocation Protein 1 in Mouse T Cells Protects Against Development of Autoimmune Arthritis but Leads to Spontaneous Osteoporosis.Authorship 956108431558581Benner L, Castro EA, Whitworth C, Venken KJT, Yang H, Fang J, Oliver B, Cook KR, Lerit DAGeneticsDrosophila Heterochromatin Stabilization Requires the Zinc-Finger Protein Small Ovary. Genetics. 2019 11; 213(3):877-895.Genetics2019-09-26T00:00:002019Drosophila Heterochromatin Stabilization Requires the Zinc-Finger Protein Small Ovary.true1Adjunct ProfessorAdjunct Professortrue1ProfessorProfessorAuthorship 962548631836712Sarrion-Perdigones A, Chang L, Gonzalez Y, Gallego-Flores T, Young DW, Venken KJTNature communicationsExamining multiple cellular pathways at once using multiplex hextuple luciferase assaying. Nat Commun. 2019 12 13; 10(1):5710.Nat Commun2019-12-13T00:00:002019Examining multiple cellular pathways at once using multiplex hextuple luciferase assaying.One Baylor PlazaHouston, 77030TXAuthorship 977908332053875Lukasik Z, Elewaut D, Venken KCancersMAIT Cells Come to the Rescue in Cancer Immunotherapy? Cancers (Basel). 2020 Feb 11; 12(2).Cancers (Basel)2020-02-11T00:00:002020MAIT Cells Come to the Rescue in Cancer Immunotherapy?SHINYAYAMAMOTOSHINYA YAMAMOTO0.000000000000000.000000000000005831YAMAMOTO, SHINYAAssistant Professor5.306450.00624858367research areas3.670220.016195625coauthor of143.949.6868760similar to1172selected publicationsANNAMALOVANNAYAANNA MALOVANNAYA0.000000000000000.000000000000005735MALOVANNAYA, ANNAAssistant ProfessorAuthorship 986193732232356Kundert P, Sarrion-Perdigones A, Gonzalez Y, Katoh-Kurasawa M, Hirose S, Lehmann P, Venken KJT, Shaulsky GNucleic acids researchA GoldenBraid cloning system for synthetic biology in social amoebae. Nucleic Acids Res. 2020 05 07; 48(8):4139-4146.Nucleic Acids Res2020-05-07T00:00:002020A GoldenBraid cloning system for synthetic biology in social amoebae.Authorship 988175232340697Dumas E, Venken K, Rosenbaum JT, Elewaut DRheumatic diseases clinics of North AmericaIntestinal Microbiota, HLA-B27, and Spondyloarthritis: Dangerous Liaisons. Rheum Dis Clin North Am. 2020 05; 46(2):213-224.Rheum Dis Clin North Am2020-05-01T00:00:002020Intestinal Microbiota, HLA-B27, and Spondyloarthritis: Dangerous Liaisons.2019-06-30NIHVENKEN, KOEN JOZEF THEO2016-07-01RESOLVING COMPLEX SYSTEMIC ENDOGENOUS EXPRESSION PATTERNS INTO SUBCELLULAR HIGH-RESOLUTION LOCALIZATIONR21OD022981Principal InvestigatorAuthorship 988636332363653Govindarajan S, Verheugen E, Venken K, Gaublomme D, Maelegheer M, Cloots E, Gysens F, De Geest BG, Cheng TY, Moody DB, Janssens S, Drennan M, Elewaut DEMBO reportsER stress in antigen-presenting cells promotes NKT cell activation through endogenous neutral lipids. EMBO Rep. 2020 06 04; 21(6):e48927.EMBO Rep2020-05-03T00:00:002020ER stress in antigen-presenting cells promotes NKT cell activation through endogenous neutral lipids.Authorship 9918973Authorship 991899632539183Sarrion-Perdigones A, Gonzalez Y, Venken KJTCurrent protocols in molecular biologyRapid and Efficient Synthetic Assembly of Multiplex Luciferase Reporter Plasmids for the Simultaneous Monitoring of Up to Six Cellular Signaling Pathways. Curr Protoc Mol Biol. 2020 06; 131(1):e121.Curr Protoc Mol Biol2020-06-01T00:00:002020Rapid and Efficient Synthetic Assembly of Multiplex Luciferase Reporter Plasmids for the Simultaneous Monitoring of Up to Six Cellular Signaling Pathways.32539239Sarrion-Perdigones A, Chang L, Gonzalez Y, Gallego-Flores T, Young DW, Venken KJTCurrent protocols in molecular biologySimultaneous Examination of Cellular Pathways using Multiplex Hextuple Luciferase Assaying. Curr Protoc Mol Biol. 2020 06; 131(1):e122.Curr Protoc Mol Biol2020-06-01T00:00:002020Simultaneous Examination of Cellular Pathways using Multiplex Hextuple Luciferase Assaying.Authorship 998639632884132Wang J, Liu H, Bertrand RE, Sarrion-Perdigones A, Gonzalez Y, Venken KJT, Chen RGenetics in medicine : official journal of the American College of Medical GeneticsA novel statistical method for interpreting the pathogenicity of rare variants. Genet Med. 2021 01; 23(1):59-68.Genet Med2020-09-04T00:00:002020A novel statistical method for interpreting the pathogenicity of rare variants.http://flypush.imgen.bcm.tmc.eduBellen Lab WebsiteTwitter Tweets Harvard Tweets2024-05-31NIHVENKEN, KOEN JOZEF THEO2020-09-01Exploring the limits of luciferase multiplexing to assay multiple cellular signaling pathways at onceR01GM138781Principal InvestigatorAuthorship 1017884333961030Lukasik Z, Gracey E, Venken K, Ritchlin C, Elewaut DRheumatology (Oxford, England)Crossing the boundaries: IL-23 and its role in linking inflammation of the skin, gut and joints. Rheumatology (Oxford). 2021 10 19; 60(Suppl 4):iv16-iv27.Rheumatology (Oxford)2021-10-19T00:00:002021Crossing the boundaries: IL-23 and its role in linking inflammation of the skin, gut and joints.true1Distinguished Service ProfessorDistinguished Service ProfessorAuthorship 1029818934525356Matinyan N, Karkhanis MS, Gonzalez Y, Jain A, Saltzman A, Malovannaya A, Sarrion-Perdigones A, Dierick HA, Venken KJTCell reportsMultiplexed drug-based selection and counterselection genetic manipulations in Drosophila. Cell Rep. 2021 09 14; 36(11):109700.Cell Rep2021-09-14T00:00:002021Multiplexed drug-based selection and counterselection genetic manipulations in Drosophila.Authorship 1030742434585147Matinyan N, Gonzalez Y, Dierick HA, Venken KJTSTAR protocolsDetermining effective drug concentrations for selection and counterselection genetics in Drosophila melanogaster. STAR Protoc. 2021 09 17; 2(3):100783.STAR Protoc2021-09-14T00:00:002021Determining effective drug concentrations for selection and counterselection genetics in Drosophila melanogaster.Authorship 10388731835333654Kandel P, Semerci F, Mishra R, Choi W, Bajic A, Baluya D, Ma L, Chen K, Cao AC, Phongmekhin T, Matinyan N, Jim?nez-Panizo A, Chamakuri S, Raji IO, Chang L, Fuentes-Prior P, MacKenzie KR, Benn CL, Est?banez-Perpi?? E, Venken K, Moore DD, Young DW, Maletic-Savatic MProceedings of the National Academy of Sciences of the United States of AmericaOleic acid is an endogenous ligand of TLX/NR2E1 that triggers hippocampal neurogenesis. Proc Natl Acad Sci U S A. 2022 03 29; 119(13):e2023784119.Proc Natl Acad Sci U S A2022-03-25T00:00:002022Oleic acid is an endogenous ligand of TLX/NR2E1 that triggers hippocampal neurogenesis.Authorship 1314261Authorship 1319635Authorship 1320262Authorship 1320793Authorship 1320921Authorship 1322128Authorship 1323643Authorship 1323787Authorship 1324991Authorship 1329141Authorship 1331791Authorship 1333031Authorship 1337508Authorship 1341573Authorship 1343245Authorship 1344271Authorship 1346301Authorship 1347016Authorship 10438148Authorship 1351871Authorship 135242435414140Chmielowiec J, Szlachcic WJ, Yang D, Scavuzzo MA, Wamble K, Sarrion-Perdigones A, Sabek OM, Venken KJT, Borowiak MNature communicationsHuman pancreatic microenvironment promotes ?-cell differentiation via non-canonical WNT5A/JNK and BMP signaling. Nat Commun. 2022 04 12; 13(1):1952.Nat Commun2022-04-12T00:00:002022Human pancreatic microenvironment promotes ?-cell differentiation via non-canonical WNT5A/JNK and BMP signaling.Authorship 1355621Authorship 13564530Authorship 1364662Authorship 1364717Authorship 1367444Authorship 137100322737083Geiser J, Venken KJ, De Lisle RC, Andrews GKPLoS geneticsA mouse model of acrodermatitis enteropathica: loss of intestine zinc transporter ZIP4 (Slc39a4) disrupts the stem cell niche and intestine integrity. PLoS Genet. 2012; 8(6):e1002766.PLoS Genet2012-06-21T00:00:002012A mouse model of acrodermatitis enteropathica: loss of intestine zinc transporter ZIP4 (Slc39a4) disrupts the stem cell niche and intestine integrity.24360277Cassidy JJ, Jha AR, Posadas DM, Giri R, Venken KJ, Ji J, Jiang H, Bellen HJ, White KP, Carthew RWCellmiR-9a minimizes the phenotypic impact of genomic diversity by buffering a transcription factor. Cell. 2013 Dec 19; 155(7):1556-67.Cell2013-12-19T00:00:002013miR-9a minimizes the phenotypic impact of genomic diversity by buffering a transcription factor.18676454Venken KJ, Kasprowicz J, Kuenen S, Yan J, Hassan BA, Verstreken PNucleic acids researchRecombineering-mediated tagging of Drosophila genomic constructs for in vivo localization and acute protein inactivation. Nucleic Acids Res. 2008 Oct; 36(18):e114.Nucleic Acids Res2008-08-01T00:00:002008Recombineering-mediated tagging of Drosophila genomic constructs for in vivo localization and acute protein inactivation.12030330Venken K, Di Maria E, Bellone E, Balestra P, Cassandrini D, Mandich P, De Jonghe P, Timmerman V, Svaren JNeurogeneticsSearch for mutations in the EGR2 corepressor proteins, NAB1 and NAB2, in human peripheral neuropathies. Neurogenetics. 2002 Mar; 4(1):37-41.Neurogenetics2002-03-01T00:00:002002Search for mutations in the EGR2 corepressor proteins, NAB1 and NAB2, in human peripheral neuropathies.Authorship 1048737635729185Beterams A, Calatayud Arroyo M, De Paepe K, De Craemer AS, Elewaut D, Venken K, Van de Wiele TScientific reportsIn vitro triple coculture with gut microbiota from spondyloarthritis patients is characterized by inter-individual differences in inflammatory responses. Sci Rep. 2022 06 21; 12(1):10475.Sci Rep2022-06-21T00:00:002022In vitro triple coculture with gut microbiota from spondyloarthritis patients is characterized by inter-individual differences in inflammatory responses.Authorship 10504156Authorship 1050546335821491Sarrion-Perdigones A, Gonzalez Y, Chang L, Gallego-Flores T, Young DW, Venken KJTMethods in molecular biology (Clifton, N.J.)Multiplex Hextuple Luciferase Assaying. Methods Mol Biol. 2022; 2524:433-456.Methods Mol Biol2022-01-01T00:00:002022Multiplex Hextuple Luciferase Assaying.35821490Sarrion-Perdigones A, Gonzalez Y, Venken KJTMethods in molecular biology (Clifton, N.J.)Synthetic Assembly DNA Cloning of Multiplex Hextuple Luciferase Reporter Plasmids. Methods Mol Biol. 2022; 2524:409-432.Methods Mol Biol2022-01-01T00:00:002022Synthetic Assembly DNA Cloning of Multiplex Hextuple Luciferase Reporter Plasmids.true1Assistant ProfessorAssistant ProfessorAuthorship 10584551836661300Mortier C, Gracey E, Coudenys J, Manuello T, Decruy T, Maelegheer M, Stappers F, Gilis E, Gaublomme D, Van Hoorebeke L, Van Welden S, Ambler C, Hegen M, Symanowicz P, Steyn S, Berstein G, Elewaut D, Venken KRheumatology (Oxford, England)ROR?t inhibition ameliorates IL-23 driven experimental psoriatic arthritis by predominantly modulating ?d-T cells. Rheumatology (Oxford). 2023 09 01; 62(9):3169-3178.Rheumatology (Oxford)2023-09-01T00:00:002023ROR?t inhibition ameliorates IL-23 driven experimental psoriatic arthritis by predominantly modulating ?d-T cells.Authorship 10635741Authorship 10635721Authorship 1063573136757287Venken KJT, Matinyan N, Gonzalez Y, Dierick HACurrent protocolsMultiplexed Transgenic Selection and Counterselection Strategies to Expedite Genetic Manipulation Workflows Using Drosophila melanogaster. Curr Protoc. 2023 Feb; 3(2):e652.Curr Protoc2023-02-01T00:00:002023Multiplexed Transgenic Selection and Counterselection Strategies to Expedite Genetic Manipulation Workflows Using Drosophila melanogaster.36757632Venken KJT, Matinyan N, Gonzalez Y, Dierick HACurrent protocolsSerial Recombineering Cloning to Build Selectable and Tagged Genomic P[acman] BAC Clones for Selection Transgenesis and Functional Gene Analysis using Drosophila melanogaster. Curr Protoc. 2023 Feb; 3(2):e675.Curr Protoc2023-02-01T00:00:002023Serial Recombineering Cloning to Build Selectable and Tagged Genomic P[acman] BAC Clones for Selection Transgenesis and Functional Gene Analysis using Drosophila melanogaster.36757602Venken KJT, Matinyan N, Gonzalez Y, Sarrion-Perdigones A, Dierick HACurrent protocolsSynthetic Assembly DNA Cloning to Build Plasmids for Multiplexed Transgenic Selection, Counterselection or Any Other Genetic Strategies Using Drosophila melanogaster. Curr Protoc. 2023 Feb; 3(2):e653.Curr Protoc2023-02-01T00:00:002023Synthetic Assembly DNA Cloning to Build Plasmids for Multiplexed Transgenic Selection, Counterselection or Any Other Genetic Strategies Using Drosophila melanogaster.Authorship 1069882137197892Venken K, Jarlborg M, Decruy T, Mortier C, Vlieghe C, Gilis E, De Craemer AS, Coudenys J, Cambr? I, Fleury D, Klimowicz A, Van den Bosch F, Hoorens A, Lobaton T, de Roock S, Sparwasser T, Nabozny G, Jacques P, Elewaut DAnnals of the rheumatic diseasesDistinct immune modulatory roles of regulatory T cells in gut versus joint inflammation in TNF-driven spondyloarthritis. Ann Rheum Dis. 2023 08; 82(8):1076-1090.Ann Rheum Dis2023-05-17T00:00:002023Distinct immune modulatory roles of regulatory T cells in gut versus joint inflammation in TNF-driven spondyloarthritis.Authorship 10740731737293832Mortier C, Quintelier K, De Craemer AS, Renson T, Deroo L, Dumas E, Verheugen E, Coudenys J, Decruy T, Lukasik Z, Van Gassen S, Saeys Y, Hoorens A, Lobat?n T, Van den Bosch F, Van de Wiele T, Venken K, Elewaut DArthritis & rheumatology (Hoboken, N.J.)Gut Inflammation in Axial Spondyloarthritis Patients is Characterized by a Marked Type 17 Skewed Mucosal Innate-like T Cell Signature. Arthritis Rheumatol. 2023 11; 75(11):1969-1982.Arthritis Rheumatol2023-10-04T00:00:002023Gut Inflammation in Axial Spondyloarthritis Patients is Characterized by a Marked Type 17 Skewed Mucosal Innate-like T Cell Signature.true1ProfessorProfessortrue1ProfessorProfessortrue1Assistant ProfessorAssistant ProfessorDepartment of Biochemistry and Molecular PharmacologyBiochemistry & Mol Pharmacologytrue1Associate ProfessorAssociate Professortrue1Adjunct ProfessorAdjunct Professortrue1Adjunct ProfessorAdjunct Professortrue1Assistant ProfessorAssistant Professortrue1Assistant ProfessorAssistant ProfessorAuthorship 1084468137984469Venken K, Decruy T, Sparwasser T, Elewaut DImmunologyTregs protect against invariant NKT cell-mediated autoimmune colitis and hepatitis. Immunology. 2024 Feb; 171(2):277-285.Immunology2023-11-20T00:00:002023Tregs protect against invariant NKT cell-mediated autoimmune colitis and hepatitis.DAMIANYOUNGDAMIAN YOUNG7119YOUNG, DAMIANAssociate ProfessorAuthorship 13921957Authorship 139220124583113Venken KJ, Bellen HJMethods (San Diego, Calif.)Chemical mutagens, transposons, and transgenes to interrogate gene function in Drosophila melanogaster. Methods. 2014 Jun 15; 68(1):15-28.Methods2014-02-28T00:00:002014Chemical mutagens, transposons, and transgenes to interrogate gene function in Drosophila melanogaster.Authorship 1518071625258387Haelterman NA, Jiang L, Li Y, Bayat V, Sandoval H, Ugur B, Tan KL, Zhang K, Bei D, Xiong B, Charng WL, Busby T, Jawaid A, David G, Jaiswal M, Venken KJ, Yamamoto S, Chen R, Bellen HJGenome researchLarge-scale identification of chemically induced mutations in Drosophila melanogaster. Genome Res. 2014 Oct; 24(10):1707-18.Genome Res2014-10-01T00:00:002014Large-scale identification of chemically induced mutations in Drosophila melanogaster.