LINYANMENGLINYAN MENG0.000000000000000.000000000000005916MENG, LINYANAssociate Professorprns:coAuthorOfcoauthor ofFaculty Rankprns:fullNamefull nameprns:hasAuthorListauthor listprns:hasFacultyRankhas faculty rankprns:hasNetworkhas networkprns:hasPublicationVenuepublished inprns:informationResourceReferenceinformation resource referenceprns:isPrimaryPositionis primary positionprns:latitudelatitudeprns:longitudelongitudeprns:mainImagephotoprns:maxWeightmaximum weightprns:medlineTAjournal title abbreviationprns:meshDescriptorUIMeSH DescriptorUIprns:meshSemanticGroupNameMeSH semantic group nameprns:minWeightminimum weightprns:numberOfAuthorsnumber of authorsprns:numberOfConnectionsnumber of connectionsprns:numberOfPublicationsnumber of publicationsprns:personIdPerson IDprns:personInPrimaryPositionperson in primary positionprns:physicalNeighborOfphysical neighborprns:positionInDepartmentposition in departmentprns:positionInDivisionposition in divisionprns:predicateNodepredicate nodeprns:publicationDatepublication dateprns:similarTosimilar toprns:sortOrdersort orderprns:uniquenessWeightuniqueness weightprns:yearyearAcademic ArticleArticleDocumentbibo:pmidPubMed IdentifierAddressvivo:address1address line 1vivo:addressCitycityvivo:addressPostalCodepostal codevivo:addressStatestate or provincevivo:authorInAuthorshipselected publicationsvivo:authorRankauthor rank in publicationAuthorshipDepartmentDivisionvivo:hasResearchArearesearch areasvivo:hrJobTitleHR job titleInformation Resourcevivo:linkAnchorTextlink anchor textvivo:linkedAuthorlinked authorvivo:linkedInformationResourcelinked information resourcevivo:mailingAddressmailing addressvivo:personInPositionpositionsPositionvivo:positionInOrganizationposition in organizationvivo:preferredTitlepreferred titleURLLinkvivo:webpagewebpagerdf:predicatepredicaterdf:typetyperdfs:labellabelConceptAgentfoaf:firstNamefirst namefoaf:lastNamelast nameOrganizationPersonAuthorship 162340125470045Meng L, Ward AJ, Chun S, Bennett CF, Beaudet AL, Rigo FNatureTowards a therapy for Angelman syndrome by targeting a long non-coding RNA. Nature. 2015 Feb 19; 518(7539):409-12.Nature2014-12-01T00:00:002014Towards a therapy for Angelman syndrome by targeting a long non-coding RNA.74Professor10Assistant Professor5Adjunct Instructor14Associate Professor42Director6Adjunct Professor47Distinguished Service ProfessorAuthorship 321341226628634Beaudet AL, Meng LHuman molecular geneticsGene-targeting pharmaceuticals for single-gene disorders. Hum Mol Genet. 2016 Apr 15; 25(R1):R18-26.Hum Mol Genet2015-11-30T00:00:002015Gene-targeting pharmaceuticals for single-gene disorders.LIUBINYANGLIUBIN YANG0.000000000000000.000000000000005039YANG, LIUBINAdjunct InstructorBOYUANBO YUAN0.000000000000000.000000000000005177YUAN, BOAssociate ProfessorAuthorship 652894127860360Meng L, Donti T, Xia F, Niu Z, Al Shamsi A, Hertecant J, Al-Jasmi F, Gibson JB, Nagakura H, Zhang J, He W, Eng C, Yang Y, Elsea SHAmerican journal of medical genetics. Part AHomozygous variants in pyrroline-5-carboxylate reductase 2 (PYCR2) in patients with progressive microcephaly and hypomyelinating leukodystrophy. Am J Med Genet A. 2017 Feb; 173(2):460-470.Am J Med Genet A2016-11-11T00:00:002016Homozygous variants in pyrroline-5-carboxylate reductase 2 (PYCR2) in patients with progressive microcephaly and hypomyelinating leukodystrophy.Authorship 654809328125085Feng Y, Ge X, Meng L, Scull J, Li J, Tian X, Zhang T, Jin W, Cheng H, Wang X, Tokita M, Liu P, Mei H, Wang Y, Li F, Schmitt ES, Zhang WV, Muzny D, Wen S, Chen Z, Yang Y, Beaudet AL, Liu X, Eng CM, Xia F, Wong LJ, Zhang JGenetics in medicine : official journal of the American College of Medical GeneticsThe next generation of population-based spinal muscular atrophy carrier screening: comprehensive pan-ethnic SMN1 copy-number and sequence variant analysis by massively parallel sequencing. Genet Med. 2017 08; 19(8):936-944.Genet Med2017-01-26T00:00:002017The next generation of population-based spinal muscular atrophy carrier screening: comprehensive pan-ethnic SMN1 copy-number and sequence variant analysis by massively parallel sequencing.22493002Meng L, Person RE, Beaudet ALHuman molecular geneticsUbe3a-ATS is an atypical RNA polymerase II transcript that represses the paternal expression of Ube3a. Hum Mol Genet. 2012 Jul 01; 21(13):3001-12.Hum Mol Genet2012-04-05T00:00:002012Ube3a-ATS is an atypical RNA polymerase II transcript that represses the paternal expression of Ube3a.Authorship 879894128973083Meng L, Pammi M, Saronwala A, Magoulas P, Ghazi AR, Vetrini F, Zhang J, He W, Dharmadhikari AV, Qu C, Ward P, Braxton A, Narayanan S, Ge X, Tokita MJ, Santiago-Sim T, Dai H, Chiang T, Smith H, Azamian MS, Robak L, Bostwick BL, Schaaf CP, Potocki L, Scaglia F, Bacino CA, Hanchard NA, Wangler MF, Scott D, Brown C, Hu J, Belmont JW, Burrage LC, Graham BH, Sutton VR, Craigen WJ, Plon SE, Lupski JR, Beaudet AL, Gibbs RA, Muzny DM, Miller MJ, Wang X, Leduc MS, Xiao R, Liu P, Shaw C, Walkiewicz M, Bi W, Xia F, Lee B, Eng CM, Yang Y, Lalani SRJAMA pediatricsUse of Exome Sequencing for Infants in Intensive Care Units: Ascertainment of Severe Single-Gene Disorders and Effect on Medical Management. JAMA Pediatr. 2017 12 04; 171(12):e173438.JAMA Pediatr2017-12-04T00:00:002017Use of Exome Sequencing for Infants in Intensive Care Units: Ascertainment of Severe Single-Gene Disorders and Effect on Medical Management.true1ProfessorProfessortrue1ProfessorProfessortrue1Associate ProfessorAssociate Professortrue1Assistant ProfessorAssistant Professortrue1Associate ProfessorAssociate Professortrue1Associate ProfessorAssociate Professortrue1ProfessorProfessortrue1Associate ProfessorAssociate ProfessorD030342Disorders1434420.721799Genetic Diseases, InbornD056892Chemicals & Drugs49690.955011Mediator ComplexD017204Disorders46790.932964Angelman SyndromeD035583Disorders2323500.770924Rare DiseasesD009421Disorders751250.875643Nervous System MalformationsAuthorship 9334061530266093Normand EA, Braxton A, Nassef S, Ward PA, Vetrini F, He W, Patel V, Qu C, Westerfield LE, Stover S, Dharmadhikari AV, Muzny DM, Gibbs RA, Dai H, Meng L, Wang X, Xiao R, Liu P, Bi W, Xia F, Walkiewicz M, Van den Veyver IB, Eng CM, Yang YGenome medicineClinical exome sequencing for fetuses with ultrasound abnormalities and a suspected Mendelian disorder. Genome Med. 2018 09 28; 10(1):74.Genome Med2018-09-28T00:00:002018Clinical exome sequencing for fetuses with ultrasound abnormalities and a suspected Mendelian disorder.Department of MedicineDepartment of Molecular & Human GeneticsMedicine-Athero & LipoproteinsMolecular & Human GeneticsBaylor College of MedicineJEFFREYROGERSJEFFREY ROGERS0.000000000000000.000000000000001513ROGERS, JEFFREYAssociate ProfessorWEIMINBIWEIMIN BI0.000000000000000.00000000000000241BI, WEIMINAssociate ProfessorCHRISTINEENGCHRISTINE ENG29.70420400000000-95.38258200000000242ENG, CHRISTINEProfessorERICBOERWINKLEERIC BOERWINKLE0.000000000000000.000000000000002653BOERWINKLE, ERICAdjunct ProfessorDONNAMUZNYDONNA MUZNY0.000000000000000.000000000000003166MUZNY, DONNAAssistant ProfessorJAMESLUPSKIJAMES LUPSKI29.71073630000000-95.396604500000003140LUPSKI, JAMESProfessorHUGOBELLENHUGO BELLEN29.71010310000000-95.397396100000003292BELLEN, HUGODistinguished Service ProfessorSANDRADARILEKSANDRA DARILEK0.000000000000000.00000000000000602DARILEK, SANDRAAssociate ProfessorQINSUNQIN SUN0.000000000000000.00000000000000480SUN, QINAssociate ProfessorPAWELSTANKIEWICZPAWEL STANKIEWICZ29.71073630000000-95.39660450000000166STANKIEWICZ, PAWELProfessorRICHARDGIBBSRICHARD GIBBS0.000000000000000.000000000000003131GIBBS, RICHARDDistinguished Service ProfessorSEEMALALANISEEMA LALANI29.71306600000000-95.39705500000000391LALANI, SEEMAProfessorAuthorship 9430682230890783Chiang T, Liu X, Wu TJ, Hu J, Sedlazeck FJ, White S, Schaid D, Andrade M, Jarvik GP, Crosslin D, Stanaway I, Carrell DS, Connolly JJ, Hakonarson H, Groopman EE, Gharavi AG, Fedotov A, Bi W, Leduc MS, Murdock DR, Jiang Y, Meng L, Eng CM, Wen S, Yang Y, Muzny DM, Boerwinkle E, Salerno W, Venner E, Gibbs RAGenetics in medicine : official journal of the American College of Medical GeneticsAtlas-CNV: a validated approach to call single-exon CNVs in the eMERGESeq gene panel. Genet Med. 2019 09; 21(9):2135-2144.Genet Med2019-03-20T00:00:002019Atlas-CNV: a validated approach to call single-exon CNVs in the eMERGESeq gene panel.Authorship 9475602231127942Cheng H, Gottlieb L, Marchi E, Kleyner R, Bhardwaj P, Rope AF, Rosenheck S, Moutton S, Philippe C, Eyaid W, Alkuraya FS, Toribio J, Mena R, Prada CE, Stessman H, Bernier R, Wermuth M, Kauffmann B, Blaumeiser B, Kooy RF, Baralle D, Mancini GMS, Conway SJ, Xia F, Chen Z, Meng L, Mihajlovic L, Marmorstein R, Lyon GJHuman molecular geneticsPhenotypic and biochemical analysis of an international cohort of individuals with variants in NAA10 and NAA15. Hum Mol Genet. 2019 09 01; 28(17):2900-2919.Hum Mol Genet2019-09-01T00:00:002019Phenotypic and biochemical analysis of an international cohort of individuals with variants in NAA10 and NAA15.Authorship 949565231216405Liu P, Meng L, Normand EA, Xia F, Song X, Ghazi A, Rosenfeld J, Magoulas PL, Braxton A, Ward P, Dai H, Yuan B, Bi W, Xiao R, Wang X, Chiang T, Vetrini F, He W, Cheng H, Dong J, Gijavanekar C, Benke PJ, Bernstein JA, Eble T, Eroglu Y, Erwin D, Escobar L, Gibson JB, Gripp K, Kleppe S, Koenig MK, Lewis AM, Natowicz M, Mancias P, Minor L, Scaglia F, Schaaf CP, Streff H, Vernon H, Uhles CL, Zackai EH, Wu N, Sutton VR, Beaudet AL, Muzny D, Gibbs RA, Posey JE, Lalani S, Shaw C, Eng CM, Lupski JR, Yang YThe New England journal of medicineReanalysis of Clinical Exome Sequencing Data. N Engl J Med. 2019 06 20; 380(25):2478-2480.N Engl J Med2019-06-20T00:00:002019Reanalysis of Clinical Exome Sequencing Data.Authorship 9526731231349857Cao Y, Tokita MJ, Chen ES, Ghosh R, Chen T, Feng Y, Gorman E, Gibellini F, Ward PA, Braxton A, Wang X, Meng L, Xiao R, Bi W, Xia F, Eng CM, Yang Y, Gambin T, Shaw C, Liu P, Stankiewicz PGenome medicineA clinical survey of mosaic single nucleotide variants in disease-causing genes detected by exome sequencing. Genome Med. 2019 07 26; 11(1):48.Genome Med2019-07-26T00:00:002019A clinical survey of mosaic single nucleotide variants in disease-causing genes detected by exome sequencing.Authorship 9606321531696996Gu S, Chen CA, Rosenfeld JA, Cope H, Launay N, Flanigan KM, Waldrop MA, Schrader R, Juusola J, Goker-Alpan O, Milunsky A, Schl?ter A, Troncoso M, Pujol A, Tan QK, Schaaf CP, Meng LHuman mutationTruncating variants in UBAP1 associated with childhood-onset nonsyndromic hereditary spastic paraplegia. Hum Mutat. 2020 03; 41(3):632-640.Hum Mutat2019-11-25T00:00:002019Truncating variants in UBAP1 associated with childhood-onset nonsyndromic hereditary spastic paraplegia.Authorship 9774962232027362Cheng H, Gottlieb L, Marchi E, Kleyner R, Bhardwaj P, Rope AF, Rosenheck S, Moutton S, Philippe C, Eyaid W, Alkuraya FS, Toribio J, Mena R, Prada CE, Stessman H, Bernier R, Wermuth M, Kauffmann B, Blaumeiser B, Kooy RF, Baralle D, Mancini GMS, Conway SJ, Xia F, Chen Z, Meng L, Mihajlovic L, Marmorstein R, Lyon GJHuman molecular geneticsPhenotypic and biochemical analysis of an international cohort of individuals with variants in NAA10 and NAA15. Hum Mol Genet. 2020 03 27; 29(5):877-878.Hum Mol Genet2020-03-27T00:00:002020Phenotypic and biochemical analysis of an international cohort of individuals with variants in NAA10 and NAA15.2450 HOLCOMBEHouston, 77021TXFANXIAFAN XIA0.000000000000000.000000000000006172XIA, FANAssociate Professor1.150450.0119042122research areas0.9680810.038028750coauthor of47.60293.8318760similar to1120selected publicationstrue1Adjunct ProfessorAdjunct ProfessorAuthorship 992572932576985Yuan B, Wang L, Liu P, Shaw C, Dai H, Cooper L, Zhu W, Anderson SA, Meng L, Wang X, Wang Y, Xia F, Xiao R, Braxton A, Peacock S, Schmitt E, Ward PA, Vetrini F, He W, Chiang T, Muzny D, Gibbs RA, Beaudet AL, Breman AM, Smith J, Cheung SW, Bacino CA, Eng CM, Yang Y, Lupski JR, Bi WGenetics in medicine : official journal of the American College of Medical GeneticsCNVs cause autosomal recessive genetic diseases with or without involvement of SNV/indels. Genet Med. 2020 10; 22(10):1633-1641.Genet Med2020-06-24T00:00:002020CNVs cause autosomal recessive genetic diseases with or without involvement of SNV/indels.true1ProfessorProfessorhttp://flypush.imgen.bcm.tmc.eduBellen Lab WebsiteAuthorship 1008817133443317Meng L, Isohanni P, Shao Y, Graham BH, Hickey SE, Brooks S, Suomalainen A, Joset P, Steindl K, Rauch A, Hackenberg A, High FA, Armstrong-Javors A, Mencacci NE, Gonz?lez-Latapi P, Kamel WA, Al-Hashel JY, Bustos BI, Hernandez AV, Krainc D, Lubbe SJ, Van Esch H, De Luca C, Ballon K, Ravelli C, Burglen L, Qebibo L, Calame DG, Mitani T, Marafi D, Pehlivan D, Saadi NW, Sahin Y, Maroofian R, Efthymiou S, Houlden H, Maqbool S, Rahman F, Gu S, Posey JE, Lupski JR, Hunter JV, Wangler MF, Carroll CJ, Yang YAnnals of neurologyMED27 Variants Cause Developmental Delay, Dystonia, and Cerebellar Hypoplasia. Ann Neurol. 2021 04; 89(4):828-833.Ann Neurol2021-02-08T00:00:002021MED27 Variants Cause Developmental Delay, Dystonia, and Cerebellar Hypoplasia.true1Distinguished Service ProfessorDistinguished Service Professortrue1Distinguished Service ProfessorDistinguished Service ProfessorAuthorship 10350673234876591Okur V, Chen Z, Vossaert L, Peacock S, Rosenfeld J, Zhao L, Du H, Calamaro E, Gerard A, Zhao S, Kelsay J, Lahr A, Mighton C, Porter HM, Siemon A, Silver J, Svihovec S, Fong CT, Grant CL, Lerner-Ellis J, Manickam K, Madan-Khetarpal S, McCandless SE, Morel CF, Schaefer GB, Berry-Kravis EM, Gates R, Gomez-Ospina N, Qiu G, Zhang TJ, Wu Z, Meng L, Liu P, Scott DA, Lupski JR, Eng CM, Wu N, Yuan BNPJ genomic medicineDe novo variants in H3-3A and H3-3B are associated with neurodevelopmental delay, dysmorphic features, and structural brain abnormalities. NPJ Genom Med. 2021 Dec 07; 6(1):104.NPJ Genom Med2021-12-07T00:00:002021De novo variants in H3-3A and H3-3B are associated with neurodevelopmental delay, dysmorphic features, and structural brain abnormalities.Authorship 10355502234906496Chen CA, Lattier J, Zhu W, Rosenfeld J, Wang L, Scott TM, Du H, Patel V, Dang A, Magoulas P, Streff H, Sebastian J, Svihovec S, Curry K, Delgado MR, Hanchard NA, Lalani S, Marom R, Madan-Khetarpal S, Saenz M, Dai H, Meng L, Xia F, Bi W, Liu P, Posey JE, Scott DA, Lupski JR, Eng CM, Xiao R, Yuan BGenetics in medicine : official journal of the American College of Medical GeneticsRetrospective analysis of a clinical exome sequencing cohort reveals the mutational spectrum and identifies candidate disease-associated loci for BAFopathies. Genet Med. 2022 02; 24(2):364-373.Genet Med2021-11-30T00:00:002021Retrospective analysis of a clinical exome sequencing cohort reveals the mutational spectrum and identifies candidate disease-associated loci for BAFopathies.Authorship 1356601Authorship 1378121true1Associate ProfessorAssociate Professor24385930Meng L, Person RE, Huang W, Zhu PJ, Costa-Mattioli M, Beaudet ALPLoS geneticsTruncation of Ube3a-ATS unsilences paternal Ube3a and ameliorates behavioral defects in the Angelman syndrome mouse model. PLoS Genet. 2013; 9(12):e1004039.PLoS Genet2013-12-26T00:00:002013Truncation of Ube3a-ATS unsilences paternal Ube3a and ameliorates behavioral defects in the Angelman syndrome mouse model.true1Associate ProfessorAssociate ProfessorAuthorship 1054832236065636Kumar RD, Meng L, Liu P, Miyake CY, Worley KC, Bi W, Lalani SRAmerican journal of medical genetics. Part AClinical exome sequencing uncovers a high frequency of Mendelian disorders in infants with stroke: A retrospective analysis. Am J Med Genet A. 2022 Nov; 188(11):3184-3190.Am J Med Genet A2022-09-06T00:00:002022Clinical exome sequencing uncovers a high frequency of Mendelian disorders in infants with stroke: A retrospective analysis.Authorship 1066168136939041Meng L, Attali R, Talmy T, Regev Y, Mizrahi N, Smirin-Yosef P, Vossaert L, Taborda C, Santana M, Machol I, Xiao R, Dai H, Eng C, Xia F, Tzur SGenetics in medicine : official journal of the American College of Medical GeneticsEvaluation of an automated genome interpretation model for rare disease routinely used in a clinical genetic laboratory. Genet Med. 2023 06; 25(6):100830.Genet Med2023-03-16T00:00:002023Evaluation of an automated genome interpretation model for rare disease routinely used in a clinical genetic laboratory.true1Associate ProfessorAssociate Professortrue1Adjunct InstructorAdjunct Instructor