ISMAELAL-RAMAHIISMAEL AL-RAMAHI0.000000000000000.000000000000005745AL-RAMAHI, ISMAELAssistant Professorprns:coAuthorOfcoauthor ofprns:endDateend dateFaculty Rankprns:fullNamefull nameprns:grantAwardedBygrant awarded byprns:hasAuthorListauthor listprns:hasFacultyRankhas faculty rankprns:hasNetworkhas networkprns:hasPublicationVenuepublished inprns:informationResourceReferenceinformation resource referenceprns:isPrimaryPositionis primary positionprns:latitudelatitudeprns:longitudelongitudeprns:mainImagephotoprns:maxWeightmaximum weightprns:medlineTAjournal title abbreviationprns:meshDescriptorUIMeSH DescriptorUIprns:meshSemanticGroupNameMeSH semantic group nameprns:minWeightminimum weightprns:numberOfAuthorsnumber of authorsprns:numberOfConnectionsnumber of connectionsprns:numberOfPublicationsnumber of publicationsprns:personIdPerson IDprns:personInPrimaryPositionperson in primary positionprns:physicalNeighborOfphysical neighborprns:positionInDepartmentposition in departmentprns:positionInDivisionposition in divisionprns:predicateNodepredicate nodeprns:principalInvestigatorNameprincipal investigator nameprns:publicationDatepublication dateprns:similarTosimilar toprns:sortOrdersort orderprns:startDatestart dateprns:uniquenessWeightuniqueness weightprns:yearyearAcademic ArticleArticleDocumentbibo:pmidPubMed IdentifierAddressvivo:address1address line 1vivo:addressCitycityvivo:addressPostalCodepostal codevivo:addressStatestate or provinceAgreementvivo:authorInAuthorshipselected publicationsvivo:authorRankauthor rank in publicationAuthorshipDepartmentDivisionGrantvivo:hasResearchArearesearch areasvivo:hasResearcherRoleresearch activitiesvivo:hrJobTitleHR job titleInformation Resourcevivo:linkAnchorTextlink anchor textvivo:linkedAuthorlinked authorvivo:linkedInformationResourcelinked information resourcevivo:mailingAddressmailing addressvivo:personInPositionpositionsPositionvivo:positionInOrganizationposition in organizationvivo:preferredTitlepreferred titleResearcher Rolevivo:researcherRoleOfresearcher role ofRolevivo:roleContributesTocontributes tovivo:sponsorAwardIdsponsor award idURLLinkvivo:webpagewebpagerdf:predicatepredicaterdf:typetyperdfs:labellabelConceptAgentfoaf:firstNamefirst namefoaf:lastNamelast nameOrganizationPerson25540325Lu XH, Mattis VB, Wang N, Al-Ramahi I, van den Berg N, Fratantoni SA, Waldvogel H, Greiner E, Osmand A, Elzein K, Xiao J, Dijkstra S, de Pril R, Vinters HV, Faull R, Signer E, Kwak S, Marugan JJ, Botas J, Fischer DF, Svendsen CN, Munoz-Sanjuan I, Yang XWScience translational medicineTargeting ATM ameliorates mutant Huntingtin toxicity in cell and animal models of Huntington's disease. Sci Transl Med. 2014 Dec 24; 6(268):268ra178.Sci Transl Med2014-12-24T00:00:002014Targeting ATM ameliorates mutant Huntingtin toxicity in cell and animal models of Huntington's disease.Authorship 161848325738228Yao Y, Cui X, Al-Ramahi I, Sun X, Li B, Hou J, Difiglia M, Palacino J, Wu ZY, Ma L, Botas J, Lu BeLifeA striatal-enriched intronic GPCR modulates huntingtin levels and toxicity. Elife. 2015 Mar 04; 4.Elife2015-03-04T00:00:002015A striatal-enriched intronic GPCR modulates huntingtin levels and toxicity.Authorship 3047793Authorship 305930326158631Calap-Quintana P, Soriano S, Llorens JV, Al-Ramahi I, Botas J, Molt? MD, Mart?nez-Sebasti?n MJPloS oneTORC1 Inhibition by Rapamycin Promotes Antioxidant Defences in a Drosophila Model of Friedreich's Ataxia. PLoS One. 2015; 10(7):e0132376.PLoS One2015-07-09T00:00:002015TORC1 Inhibition by Rapamycin Promotes Antioxidant Defences in a Drosophila Model of Friedreich's Ataxia.26165689El-Daher MT, Hangen E, Bruy?re J, Poizat G, Al-Ramahi I, Pardo R, Bourg N, Souquere S, Mayet C, Pierron G, L?v?que-Fort S, Botas J, Humbert S, Saudou FThe EMBO journalHuntingtin proteolysis releases non-polyQ fragments that cause toxicity through dynamin 1 dysregulation. EMBO J. 2015 Sep 02; 34(17):2255-71.EMBO J2015-07-12T00:00:002015Huntingtin proteolysis releases non-polyQ fragments that cause toxicity through dynamin 1 dysregulation.74Professor10Assistant Professor54Instructor21Chair14Associate Professor42Director6Adjunct Professor47Distinguished Service ProfessorAuthorship 322562626900923Langfelder P, Cantle JP, Chatzopoulou D, Wang N, Gao F, Al-Ramahi I, Lu XH, Ramos EM, El-Zein K, Zhao Y, Deverasetty S, Tebbe A, Schaab C, Lavery DJ, Howland D, Kwak S, Botas J, Aaronson JS, Rosinski J, Coppola G, Horvath S, Yang XWNature neuroscienceIntegrated genomics and proteomics define huntingtin CAG length-dependent networks in mice. Nat Neurosci. 2016 Apr; 19(4):623-33.Nat Neurosci2016-02-22T00:00:002016Integrated genomics and proteomics define huntingtin CAG length-dependent networks in mice.Authorship 325402327433942Soriano S, Calap-Quintana P, Llorens JV, Al-Ramahi I, Guti?rrez L, Mart?nez-Sebasti?n MJ, Botas J, Molt? MDPloS oneMetal Homeostasis Regulators Suppress FRDA Phenotypes in a Drosophila Model of the Disease. PLoS One. 2016; 11(7):e0159209.PLoS One2016-07-19T00:00:002016Metal Homeostasis Regulators Suppress FRDA Phenotypes in a Drosophila Model of the Disease.18166084Al-Ramahi I, P?rez AM, Lim J, Zhang M, Sorensen R, de Haro M, Branco J, Pulst SM, Zoghbi HY, Botas JPLoS geneticsdAtaxin-2 mediates expanded Ataxin-1-induced neurodegeneration in a Drosophila model of SCA1. PLoS Genet. 2007 Dec 28; 3(12):e234.PLoS Genet2007-11-16T00:00:002007dAtaxin-2 mediates expanded Ataxin-1-induced neurodegeneration in a Drosophila model of SCA1.Authorship 328236627720485Lasagna-Reeves CA, de Haro M, Hao S, Park J, Rousseaux MW, Al-Ramahi I, Jafar-Nejad P, Vilanova-Velez L, See L, De Maio A, Nitschke L, Wu Z, Troncoso JC, Westbrook TF, Tang J, Botas J, Zoghbi HYNeuronReduction of Nuak1 Decreases Tau and Reverses Phenotypes in a Tauopathy Mouse Model. Neuron. 2016 Oct 19; 92(2):407-418.Neuron2016-10-06T00:00:002016Reduction of Nuak1 Decreases Tau and Reverses Phenotypes in a Tauopathy Mouse Model.22511757Zhang N, Li B, Al-Ramahi I, Cong X, Held JM, Kim E, Botas J, Gibson BW, Ellerby LMThe Journal of biological chemistryInhibition of lipid signaling enzyme diacylglycerol kinase epsilon attenuates mutant huntingtin toxicity. J Biol Chem. 2012 Jun 15; 287(25):21204-13.J Biol Chem2012-04-16T00:00:002012Inhibition of lipid signaling enzyme diacylglycerol kinase epsilon attenuates mutant huntingtin toxicity.23719381Park J, Al-Ramahi I, Tan Q, Mollema N, Diaz-Garcia JR, Gallego-Flores T, Lu HC, Lagalwar S, Duvick L, Kang H, Lee Y, Jafar-Nejad P, Sayegh LS, Richman R, Liu X, Gao Y, Shaw CA, Arthur JSC, Orr HT, Westbrook TF, Botas J, Zoghbi HYNatureRAS-MAPK-MSK1 pathway modulates ataxin 1 protein levels and toxicity in SCA1. Nature. 2013 Jun 20; 498(7454):325-331.Nature2013-05-29T00:00:002013RAS-MAPK-MSK1 pathway modulates ataxin 1 protein levels and toxicity in SCA1.16831871Al-Ramahi I, Lam YC, Chen HK, de Gouyon B, Zhang M, P?rez AM, Branco J, de Haro M, Patterson C, Zoghbi HY, Botas JThe Journal of biological chemistryCHIP protects from the neurotoxicity of expanded and wild-type ataxin-1 and promotes their ubiquitination and degradation. J Biol Chem. 2006 Sep 08; 281(36):26714-24.J Biol Chem2006-07-10T00:00:002006CHIP protects from the neurotoxicity of expanded and wild-type ataxin-1 and promotes their ubiquitination and degradation.17984172Branco J, Al-Ramahi I, Ukani L, P?rez AM, Fernandez-Funez P, Rinc?n-Limas D, Botas JHuman molecular geneticsComparative analysis of genetic modifiers in Drosophila points to common and distinct mechanisms of pathogenesis among polyglutamine diseases. Hum Mol Genet. 2008 Feb 01; 17(3):376-90.Hum Mol Genet2007-11-05T00:00:002007Comparative analysis of genetic modifiers in Drosophila points to common and distinct mechanisms of pathogenesis among polyglutamine diseases.20670829Miller JP, Holcomb J, Al-Ramahi I, de Haro M, Gafni J, Zhang N, Kim E, Sanhueza M, Torcassi C, Kwak S, Botas J, Hughes RE, Ellerby LMNeuronMatrix metalloproteinases are modifiers of huntingtin proteolysis and toxicity in Huntington's disease. Neuron. 2010 Jul 29; 67(2):199-212.Neuron2010-07-29T00:00:002010Matrix metalloproteinases are modifiers of huntingtin proteolysis and toxicity in Huntington's disease.Authorship 756631727779468Rousseaux MW, de Haro M, Lasagna-Reeves CA, De Maio A, Park J, Jafar-Nejad P, Al-Ramahi I, Sharma A, See L, Lu N, Vilanova-Velez L, Klisch TJ, Westbrook TF, Troncoso JC, Botas J, Zoghbi HYeLifeTRIM28 regulates the nuclear accumulation and toxicity of both alpha-synuclein and tau. Elife. 2016 10 25; 5.Elife2016-10-25T00:00:002016TRIM28 regulates the nuclear accumulation and toxicity of both alpha-synuclein and tau.22794259Shirasaki DI, Greiner ER, Al-Ramahi I, Gray M, Boontheung P, Geschwind DH, Botas J, Coppola G, Horvath S, Loo JA, Yang XWNeuronNetwork organization of the huntingtin proteomic interactome in mammalian brain. Neuron. 2012 Jul 12; 75(1):41-57.Neuron2012-07-12T00:00:002012Network organization of the huntingtin proteomic interactome in mammalian brain.23637619de Haro M, Al-Ramahi I, Jones KR, Holth JK, Timchenko LT, Botas JPLoS geneticsSmaug/SAMD4A restores translational activity of CUGBP1 and suppresses CUG-induced myopathy. PLoS Genet. 2013 Apr; 9(4):e1003445.PLoS Genet2013-04-18T00:00:002013Smaug/SAMD4A restores translational activity of CUGBP1 and suppresses CUG-induced myopathy.16723374de Haro M, Al-Ramahi I, De Gouyon B, Ukani L, Rosa A, Faustino NA, Ashizawa T, Cooper TA, Botas JHuman molecular geneticsMBNL1 and CUGBP1 modify expanded CUG-induced toxicity in a Drosophila model of myotonic dystrophy type 1. Hum Mol Genet. 2006 Jul 01; 15(13):2138-45.Hum Mol Genet2006-05-24T00:00:002006MBNL1 and CUGBP1 modify expanded CUG-induced toxicity in a Drosophila model of myotonic dystrophy type 1.23209424Miller JP, Yates BE, Al-Ramahi I, Berman AE, Sanhueza M, Kim E, de Haro M, DeGiacomo F, Torcassi C, Holcomb J, Gafni J, Mooney SD, Botas J, Ellerby LM, Hughes REPLoS geneticsA genome-scale RNA-interference screen identifies RRAS signaling as a pathologic feature of Huntington's disease. PLoS Genet. 2012; 8(11):e1003042.PLoS Genet2012-11-29T00:00:002012A genome-scale RNA-interference screen identifies RRAS signaling as a pathologic feature of Huntington's disease.Authorship 881781129256861Al-Ramahi I, Giridharan SSP, Chen YC, Patnaik S, Safren N, Hasegawa J, de Haro M, Wagner Gee AK, Titus SA, Jeong H, Clarke J, Krainc D, Zheng W, Irvine RF, Barmada S, Ferrer M, Southall N, Weisman LS, Botas J, Marugan JJeLifeInhibition of PIP4K? ameliorates the pathological effects of mutant huntingtin protein. Elife. 2017 12 26; 6.Elife2017-12-26T00:00:002017Inhibition of PIP4K? ameliorates the pathological effects of mutant huntingtin protein.23525043Lu B, Al-Ramahi I, Valencia A, Wang Q, Berenshteyn F, Yang H, Gallego-Flores T, Ichcho S, Lacoste A, Hild M, Difiglia M, Botas J, Palacino JNature neuroscienceIdentification of NUB1 as a suppressor of mutant Huntington toxicity via enhanced protein clearance. Nat Neurosci. 2013 May; 16(5):562-70.Nat Neurosci2013-03-24T00:00:002013Identification of NUB1 as a suppressor of mutant Huntington toxicity via enhanced protein clearance.true1Assistant ProfessorAssistant Professortrue1Associate ProfessorAssociate Professortrue1Assistant ProfessorAssistant Professortrue1Distinguished Service ProfessorDistinguished Service Professortrue1ProfessorProfessorD004331Living Beings2158260.623894Drosophila melanogaster30249792Rousseaux MWC, V?zquez-V?lez GE, Al-Ramahi I, Jeong HH, Bajic A, Revelli JP, Ye H, Phan ET, Deger JM, Perez AM, Kim JY, Lavery LA, Xu Q, Li MZ, Kang H, Kim JJ, Shulman JM, Westbrook TF, Elledge SJ, Liu Z, Botas J, Zoghbi HYThe Journal of neuroscience : the official journal of the Society for NeuroscienceA Druggable Genome Screen Identifies Modifiers of a-Synuclein Levels via a Tiered Cross-Species Validation Approach. J Neurosci. 2018 10 24; 38(43):9286-9301.J Neurosci2018-09-24T00:00:002018A Druggable Genome Screen Identifies Modifiers of a-Synuclein Levels via a Tiered Cross-Species Validation Approach.Authorship 9205141Authorship 9308022Authorship 932900229936182Al-Ramahi I, Lu B, Di Paola S, Pang K, de Haro M, Peluso I, Gallego-Flores T, Malik NT, Erikson K, Bleiberg BA, Avalos M, Fan G, Rivers LE, Laitman AM, Diaz-Garc?a JR, Hild M, Palacino J, Liu Z, Medina DL, Botas JCell systemsHigh-Throughput Functional Analysis Distinguishes Pathogenic, Nonpathogenic, and Compensatory Transcriptional Changes in Neurodegeneration. Cell Syst. 2018 07 25; 7(1):28-40.e4.Cell Syst2018-06-20T00:00:002018High-Throughput Functional Analysis Distinguishes Pathogenic, Nonpathogenic, and Compensatory Transcriptional Changes in Neurodegeneration.30753434Huichalaf CH, Al-Ramahi I, Park KW, Grunke SD, Lu N, de Haro M, El-Zein K, Gallego-Flores T, Perez AM, Jung SY, Botas J, Zoghbi HY, Jankowsky JLHuman molecular geneticsCross-species genetic screens to identify kinase targets for APP reduction in Alzheimer's disease. Hum Mol Genet. 2019 06 15; 28(12):2014-2029.Hum Mol Genet2019-06-15T00:00:002019Cross-species genetic screens to identify kinase targets for APP reduction in Alzheimer's disease.D009419Chemicals & Drugs55914870.564358Nerve Tissue ProteinsD006816Disorders441350.894393Huntington Disease2019-08-31NIHAL-RAMAHI, ISMAEL2016-09-01Behavioral and cell-based complementary screens to identify druggable targets modulating tau protein levelsR21NS096395Principal InvestigatorD004330Living Beings2288180.663794DrosophilaDepartment of NeurologyDepartment of PediatricsDepartment of Molecular & Cellular BiologyDepartment of Molecular & Human GeneticsMolecular & Cellular BiologyMolecular & Human GeneticsNeurologyPediatrics-NeurologyBaylor College of MedicineWEIMINBIWEIMIN BI0.000000000000000.00000000000000241BI, WEIMINAssociate ProfessorBRENDANLEEBRENDAN LEE0.000000000000000.000000000000002022LEE, BRENDANProfessorJOSEPHJANKOVICJOSEPH JANKOVIC0.000000000000000.000000000000002398JANKOVIC, JOSEPHProfessorJOSHUASHULMANJOSHUA SHULMAN29.70508570000000-95.401808700000004522SHULMAN, JOSHUAProfessorHUDAZOGHBIHUDA ZOGHBI29.71010310000000-95.397396100000002830ZOGHBI, HUDADistinguished Service ProfessorRONALDDAVISRONALD DAVIS0.000000000000000.000000000000003208DAVIS, RONALDAdjunct ProfessorHUGOBELLENHUGO BELLEN29.71010310000000-95.397396100000003292BELLEN, HUGODistinguished Service ProfessorHUIZHENGHUI ZHENG0.000000000000000.000000000000003105ZHENG, HUIProfessorRICHARDGIBBSRICHARD GIBBS0.000000000000000.000000000000003131GIBBS, RICHARDDistinguished Service ProfessorJUANBOTASJUAN BOTAS29.70508570000000-95.401808700000003330BOTAS, JUANProfessorOLIVIERLICHTARGEOLIVIER LICHTARGE0.000000000000000.000000000000003574LICHTARGE, OLIVIERProfessorD00007105822600.967466Huntingtin Proteintrue1Adjunct ProfessorAdjunct Professortrue1InstructorInstructortrue1ProfessorProfessor1250 MOURSUND STREETHouston, 77030TX2.433620.00484151220research areas2.379790.02950132coauthor of48.3164.6412160similar to1141selected publicationsMARIADE HAROMARIA DE HARO0.000000000000000.000000000000005746DE HARO, MARIAInstructorhttp://flypush.imgen.bcm.tmc.eduBellen Lab WebsiteAuthorship 1011247233576571Kim YW, Al-Ramahi I, Koire A, Wilson SJ, Konecki DM, Mota S, Soleimani S, Botas J, Lichtarge OAlzheimer's & dementia : the journal of the Alzheimer's AssociationHarnessing the paradoxical phenotypes of APOE ?2 and APOE ?4 to identify genetic modifiers in Alzheimer's disease. Alzheimers Dement. 2021 05; 17(5):831-846.Alzheimers Dement2020-12-07T00:00:002020Harnessing the paradoxical phenotypes of APOE ?2 and APOE ?4 to identify genetic modifiers in Alzheimer's disease.Authorship 1013627933709453Lee WS, Lavery L, Rousseaux MWC, Rutledge EB, Jang Y, Wan YW, Wu SR, Kim W, Al-Ramahi I, Rath S, Adamski CJ, Bondar VV, Tewari A, Soleimani S, Mota S, Yalamanchili HK, Orr HT, Liu Z, Botas J, Zoghbi HYThe EMBO journalDual targeting of brain region-specific kinases potentiates neurological rescue in Spinocerebellar ataxia type 1. EMBO J. 2021 04 01; 40(7):e106106.EMBO J2021-03-11T00:00:002021Dual targeting of brain region-specific kinases potentiates neurological rescue in Spinocerebellar ataxia type 1.Authorship 1014647333772540Suart CE, Perez AM, Al-Ramahi I, Maiuri T, Botas J, Truant RHuman molecular geneticsSpinocerebellar Ataxia Type 1 protein Ataxin-1 is signaled to DNA damage by ataxia-telangiectasia mutated kinase. Hum Mol Genet. 2021 05 17; 30(8):706-715.Hum Mol Genet2021-05-17T00:00:002021Spinocerebellar Ataxia Type 1 protein Ataxin-1 is signaled to DNA damage by ataxia-telangiectasia mutated kinase.Authorship 10165981533871358Onur TS, Laitman A, Zhao H, Keyho R, Kim H, Wang J, Mair M, Wang H, Li L, Perez A, de Haro M, Wan YW, Allen G, Lu B, Al-Ramahi I, Liu Z, Botas JeLifeDownregulation of glial genes involved in synaptic function mitigates Huntington's disease pathogenesis. Elife. 2021 04 19; 10.Elife2021-04-19T00:00:002021Downregulation of glial genes involved in synaptic function mitigates Huntington's disease pathogenesis.true1ProfessorProfessortrue1Distinguished Service ProfessorDistinguished Service Professortrue1ProfessorProfessortrue1ProfessorProfessor2026-06-30NIHAL-RAMAHI, ISMAEL ;JANKOWSKY, JOANNA L;LICHTARGE, OLIVIER2021-09-15Decoding the impact of sex differences on Alzheimer's disease riskR01AG074009Co-Principal Investigatortrue1Distinguished Service ProfessorDistinguished Service ProfessorAuthorship 1033780334741261Zhang X, Wen X, Al-Ramahi I, Botas J, Lu B, Fu YNeuroscience bulletinInhibition of HIPK3 by AST487 Ameliorates Mutant HTT-Induced Neurotoxicity and Apoptosis via Enhanced Autophagy. Neurosci Bull. 2022 Jan; 38(1):99-103.Neurosci Bull2021-11-05T00:00:002021Inhibition of HIPK3 by AST487 Ameliorates Mutant HTT-Induced Neurotoxicity and Apoptosis via Enhanced Autophagy.Authorship 1039758535148841Greco TM, Secker C, Ramos ES, Federspiel JD, Liu JP, Perez AM, Al-Ramahi I, Cantle JP, Carroll JB, Botas J, Zeitlin SO, Wanker EE, Cristea IMCell systemsDynamics of huntingtin protein interactions in the striatum identifies candidate modifiers of Huntington disease. Cell Syst. 2022 04 20; 13(4):304-320.e5.Cell Syst2022-02-10T00:00:002022Dynamics of huntingtin protein interactions in the striatum identifies candidate modifiers of Huntington disease.Authorship 1325431Authorship 1330481Authorship 1330602Authorship 1334091Authorship 1334911Authorship 1346583Authorship 1353343Authorship 1363633Authorship 1364822Authorship 1367832Authorship 1371682Authorship 137556319941006de Haro M, Al-Ramahi I, Benito-Sipos J, L?pez-Arias B, Dorado B, Veenstra JA, Herrero PCell and tissue researchDetailed analysis of leucokinin-expressing neurons and their candidate functions in the Drosophila nervous system. Cell Tissue Res. 2010 Feb; 339(2):321-36.Cell Tissue Res2009-11-26T00:00:002009Detailed analysis of leucokinin-expressing neurons and their candidate functions in the Drosophila nervous system.Authorship 1044924235499073Lee WS, Al-Ramahi I, Jeong HH, Jang Y, Lin T, Adamski CJ, Lavery LA, Rath S, Richman R, Bondar VV, Alcala E, Revelli JP, Orr HT, Liu Z, Botas J, Zoghbi HYThe Journal of clinical investigationCross-species genetic screens identify transglutaminase 5 as a regulator of polyglutamine-expanded ataxin-1. J Clin Invest. 2022 05 02; 132(9).J Clin Invest2022-05-02T00:00:002022Cross-species genetic screens identify transglutaminase 5 as a regulator of polyglutamine-expanded ataxin-1.Authorship 1051045335864371Zhang X, Wen X, Al-Ramahi I, Botas J, Lu B, Fu YNeuroscience bulletinCorrection: Inhibition of HIPK3 by AST487 Ameliorates Mutant HTT-Induced Neurotoxicity and Apoptosis via Enhanced Autophagy. Neurosci Bull. 2022 Sep; 38(9):1123.Neurosci Bull2022-09-01T00:00:002022Correction: Inhibition of HIPK3 by AST487 Ameliorates Mutant HTT-Induced Neurotoxicity and Apoptosis via Enhanced Autophagy.DONGSUPARKDONGSU PARK0.000000000000000.000000000000007040PARK, DONGSUAssistant ProfessorAuthorship 10591843Authorship 105992110Authorship 1056339336268052Lagisetty Y, Bourquard T, Al-Ramahi I, Mangleburg CG, Mota S, Soleimani S, Shulman JM, Botas J, Lee K, Lichtarge OCell genomicsIdentification of risk genes for Alzheimer's disease by gene embedding. Cell Genom. 2022 Sep 14; 2(9).Cell Genom2022-07-26T00:00:002022Identification of risk genes for Alzheimer's disease by gene embedding.36610398Kim J, de Haro M, Al-Ramahi I, Garaicoechea LL, Jeong HH, Sonn JY, Tadros B, Liu Z, Botas J, Zoghbi HYNeuronEvolutionarily conserved regulators of tau identify targets for new therapies. Neuron. 2023 03 15; 111(6):824-838.e7.Neuron2023-01-06T00:00:002023Evolutionarily conserved regulators of tau identify targets for new therapies.36173927Li J, Amoh BK, McCormick E, Tarkunde A, Zhu KF, Perez A, Mair M, Moore J, Shulman JM, Al-Ramahi I, Botas JHuman molecular geneticsIntegration of transcriptome-wide association study with neuronal dysfunction assays provides functional genomics evidence for Parkinson's disease genes. Hum Mol Genet. 2023 01 27; 32(4):685-695.Hum Mol Genet2023-01-27T00:00:002023Integration of transcriptome-wide association study with neuronal dysfunction assays provides functional genomics evidence for Parkinson's disease genes.Authorship 1065011436865102Han X, Wang W, Ma LH, Al-Ramahi I, Botas J, MacKenzie K, Allen GI, Young DW, Liu Z, Maletic-Savatic MbioRxiv : the preprint server for biologySPA-STOCSY: An Automated Tool for Identification of Annotated and Non-Annotated Metabolites in High-Throughput NMR Spectra. bioRxiv. 2023 Feb 22.bioRxiv2023-02-22T00:00:002023SPA-STOCSY: An Automated Tool for Identification of Annotated and Non-Annotated Metabolites in High-Throughput NMR Spectra.Authorship 1067493836993574Edwards GA, Wood CA, Nguyen Q, Kim PJ, Gomez-Gutierrez R, Park KW, Zurhellen C, Al-Ramahi I, Jankowsky JLbioRxiv : the preprint server for biologyTMEM106B coding variant is protective and deletion detrimental in a mouse model of tauopathy. bioRxiv. 2023 Mar 25.bioRxiv2023-03-25T00:00:002023TMEM106B coding variant is protective and deletion detrimental in a mouse model of tauopathy.Authorship 10689471437064812Benyair R, Giridharan SSP, Rivero-R?os P, Hasegawa J, Bristow E, Eskelinen EL, Shmueli MD, Fishbain-Yoskovitz V, Merbl Y, Sharkey LM, Paulson HL, Hanson PI, Patnaik S, Al-Ramahi I, Botas J, Marugan J, Weisman LSAutophagy reportsUpregulation of the ESCRT pathway and multivesicular bodies accelerates degradation of proteins associated with neurodegeneration. Autophagy Rep. 2023; 2(1).Autophagy Rep2023-01-22T00:00:002023Upregulation of the ESCRT pathway and multivesicular bodies accelerates degradation of proteins associated with neurodegeneration.Authorship 10697643Authorship 10709281337200393Yu M, Ye H, De-Paula RB, Mangleburg CG, Wu T, Lee TV, Li Y, Duong D, Phillips B, Cruchaga C, Allen GI, Seyfried NT, Al-Ramahi I, Botas J, Shulman JMPLoS geneticsFunctional screening of lysosomal storage disorder genes identifies modifiers of alpha-synuclein neurotoxicity. PLoS Genet. 2023 05; 19(5):e1010760.PLoS Genet2023-05-18T00:00:002023Functional screening of lysosomal storage disorder genes identifies modifiers of alpha-synuclein neurotoxicity.37179358Bourquard T, Lee K, Al-Ramahi I, Pham M, Shapiro D, Lagisetty Y, Soleimani S, Mota S, Wilhelm K, Samieinasab M, Kim YW, Huh E, Asmussen J, Katsonis P, Botas J, Lichtarge ONature communicationsFunctional variants identify sex-specific genes and pathways in Alzheimer's Disease. Nat Commun. 2023 05 13; 14(1):2765.Nat Commun2023-05-13T00:00:002023Functional variants identify sex-specific genes and pathways in Alzheimer's Disease.Authorship 1072883937219079Wu T, Deger JM, Ye H, Guo C, Dhindsa J, Pekarek BT, Al-Ouran R, Liu Z, Al-Ramahi I, Botas J, Shulman JMeLifeTau polarizes an aging transcriptional signature to excitatory neurons and glia. Elife. 2023 May 23; 12.Elife2023-05-23T00:00:002023Tau polarizes an aging transcriptional signature to excitatory neurons and glia.true1ProfessorProfessorAuthorship 1555564