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Jeffrey David Steimle

TitlePostdoc Fellows and Associates
InstitutionBaylor College of Medicine
DepartmentPostDoc
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    Collapse Research 
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    K99HL169742     (STEIMLE, JEFFREY DAVID)Aug 9, 2023 - Jul 31, 2025
    NIH
    Left-right asymmetry and PITX2 in atrial fibrillation
    Role: Principal Investigator
    F32HL156465     (STEIMLE, JEFFREY DAVID)Jun 15, 2021 - Jun 14, 2023
    NIH
    Gender-Dependent Regulation of Pitx2 in Atrial Fibrillation
    Role: Principal Investigator

    Collapse Bibliographic 
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    Publications listed below are automatically derived from MEDLINE/PubMed and other sources, which might result in incorrect or missing publications. Faculty can login to make corrections and additions.
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    PMC Citations indicate the number of times the publication was cited by articles in PubMed Central, and the Altmetric score represents citations in news articles and social media. (Note that publications are often cited in additional ways that are not shown here.) Fields are based on how the National Library of Medicine (NLM) classifies the publication's journal and might not represent the specific topic of the publication. Translation tags are based on the publication type and the MeSH terms NLM assigns to the publication. Some publications (especially newer ones and publications not in PubMed) might not yet be assigned Field or Translation tags.) Click a Field or Translation tag to filter the publications.
    1. Steimle JD, Zhao Y, Meng F, Taylor ME, Turaga D, Adachi I, Li X, Martin JF. Single-nuclei transcriptomics reveals TBX5-dependent targets in a patient with Holt-Oram syndrome. J Clin Invest. 2024 Nov 14. PMID: 39541167.
      Citations:    Fields:    
    2. Olivey HE, Zhou P, Ikegami K, Pu WT, McNally EM, Svensson EC, Broman MT, Nadadur RD, Perez-Cervantes C, Burnicka-Turek O, Lazarevic S, Gams A, Laforest B, Steimle JD, Iddir S, Wang Z, Smith L, Mazurek SR, Gadek M, Shen KM, Khan Z, Theisen JWM, Yang XH, Efimov IR, Weber CR, Moskowitz IP. A Genomic Link From Heart Failure to Atrial Fibrillation Risk: FOG2 Modulates a TBX5/GATA4-Dependent Atrial Gene Regulatory Network. Circulation. 2024 Apr 09; 149(15):1205-1230. PMID: 38189150; PMCID: PMC11152454.
      Citations:    Fields:    Translation:HumansAnimals
    3. Steimle JD, Martin JF. Sweet and sour story of maternal diabetes and birth defects. Nat Cardiovasc Res. 2023 Dec; 2(12):1107-1108. PMID: 39196143.
      Citations:    Translation:Humans
    4. Long H, Steimle JD, Grisanti Canozo FJ, Kim JH, Li X, Morikawa Y, Park M, Turaga D, Adachi I, Wythe JD, Samee MAH, Martin JF, Long H, Steimle JD, Grisanti Canozo FJ, Kim JH, Li X, Morikawa Y, Park M, Turaga D, Adachi I, Wythe JD, Samee MAH, Martin JF. Endothelial cells adopt a pro-reparative immune responsive signature during cardiac injury. Life Sci Alliance. 2024 02; 7(2). PMID: 38012001; PMCID: PMC10681909.
      Citations:    Fields:    Translation:HumansAnimalsCells
    5. Tsai CR, Kim J, Li X, Czarnewski P, Li R, Meng F, Zheng M, Zhao X, Steimle J, Grisanti F, Wang J, Samee MAH, Martin J. Hippo-deficient cardiac fibroblasts differentiate into osteochondroprogenitors. bioRxiv. 2023 Sep 08. PMID: 38529510; PMCID: PMC10962739.
      Citations: 8     
    6. Steimle JD, Kim C, Rowton M, Nadadur RD, Wang Z, Stocker M, Hoffmann AD, Hanson E, Kweon J, Sinha T, Choi K, Black BL, Cunningham JM, Moskowitz IP, Ikegami K. ETV2 primes hematoendothelial gene enhancers prior to hematoendothelial fate commitment. Cell Rep. 2023 06 27; 42(6):112665. PMID: 37330911; PMCID: PMC10592526.
      Citations: 1     Fields:    Translation:Cells
    7. Steimle JD, Martin JF. Regrowing the heart, one TREE at a time. Cell Stem Cell. 2023 01 05; 30(1):1-2. PMID: 36608673.
      Citations:    Fields:    Translation:AnimalsCells
    8. Steimle JD, Hong CC, Petropoulou E, Jamshidi Y, Vasan RS, Yang Q, Moskowitz IP, Bersell KR, Yang T, Mosley JD, Glazer AM, Hale AT, Kryshtal DO, Kim K, Brown JD, Salem JE, Campbell CC, Wells QS, Johnson AN, Short L, Blair MA, Behr ER, Benson MD, Keyes MJ, Ngo D, Gerszten RE, Shaffer C, Parikh S, Sheng Q, Kannankeril PJ, York JD, Wang TJ, Knollmann BC, Roden DM. Transcriptional Dysregulation Underlies Both Monogenic Arrhythmia Syndrome and Common Modifiers of Cardiac Repolarization. Circulation. 2023 03 07; 147(10):824-840. PMID: 36524479; PMCID: PMC9992308.
      Citations: 5     Fields:    Translation:HumansAnimalsCells
    9. Mart?nez Traverso IM, Steimle JD, Zhao X, Wang J, Martin JF. LATS1/2 control TGFB-directed epithelial-to-mesenchymal transition in the murine dorsal cranial neuroepithelium through YAP regulation. Development. 2022 09 15; 149(18). PMID: 36125128; PMCID: PMC9587805.
      Citations:    
    10. Rowton M, Perez-Cervantes C, Hur S, Jacobs-Li J, Lu E, Deng N, Guzzetta A, Hoffmann AD, Stocker M, Steimle JD, Lazarevic S, Oubaha S, Yang XH, Kim C, Yu S, Eckart H, Koska M, Hanson E, Chan SSK, Garry DJ, Kyba M, Basu A, Ikegami K, Pott S, Moskowitz IP. Hedgehog signaling activates a mammalian heterochronic gene regulatory network controlling differentiation timing across lineages. Dev Cell. 2022 09 26; 57(18):2181-2203.e9. PMID: 36108627; PMCID: PMC10506397.
      Citations:    
    11. Steimle JD, Grisanti Canozo FJ, Park M, Kadow ZA, Samee MAH, Martin JF. Decoding the PITX2-controlled genetic network in atrial fibrillation. JCI Insight. 2022 06 08; 7(11). PMID: 35471998; PMCID: PMC9221021.
      Citations:    Fields:    Translation:Humans
    12. Rankin SA, Steimle JD, Yang XH, Rydeen AB, Agarwal K, Chaturvedi P, Ikegami K, Herriges MJ, Moskowitz IP, Zorn AM. Tbx5 drives Aldh1a2 expression to regulate a RA-Hedgehog-Wnt gene regulatory network coordinating cardiopulmonary development. Elife. 2021 10 13; 10. PMID: 34643182; PMCID: PMC8555986.
      Citations: 1     Fields:    Translation:AnimalsCells
    13. Steimle JD, Tsai CR, Martin JF. Enhancing Pace: Identifying and Validating the Cis-Regulatory Landscape of the Sinoatrial Node. Circ Res. 2020 12 04; 127(12):1519-1521. PMID: 33270546; PMCID: PMC7721045.
      Citations:    Fields:    Translation:Humans
    14. Burnicka-Turek O, Broman MT, Steimle JD, Boukens BJ, Petrenko NB, Ikegami K, Nadadur RD, Qiao Y, Arnolds DE, Yang XH, Patel VV, Nobrega MA, Efimov IR, Moskowitz IP. Transcriptional Patterning of the Ventricular Cardiac Conduction System. Circ Res. 2020 07 17; 127(3):e94-e106. PMID: 32290757; PMCID: PMC8328577.
      Citations: 8     Fields:    Translation:HumansAnimalsCells
    15. Steimle JD, Rankin SA, Slagle CE, Bekeny J, Rydeen AB, Chan SS, Kweon J, Yang XH, Ikegami K, Nadadur RD, Rowton M, Hoffmann AD, Lazarevic S, Thomas W, Boyle Anderson EAT, Horb ME, Luna-Zurita L, Ho RK, Kyba M, Jensen B, Zorn AM, Conlon FL, Moskowitz IP. Evolutionarily conserved Tbx5-Wnt2/2b pathway orchestrates cardiopulmonary development. Proc Natl Acad Sci U S A. 2018 11 06; 115(45):E10615-E10624. PMID: 30352852; PMCID: PMC6233116.
      Citations: 18     Fields:    Translation:AnimalsCells
    16. Hoffmann AD, Yang XH, Burnicka-Turek O, Bosman JD, Ren X, Xie L, Steimle JD, Vokes SA, McMahon AP, Kalinichenko VV, Moskowitz IP. Correction: Foxf Genes Integrate Tbx5 and Hedgehog Pathways in the Second Heart Field for Cardiac Septation. PLoS Genet. 2016 Dec; 12(12):e1006533. PMID: 28033319; PMCID: PMC5199006.
      Citations:    Fields:    
    17. Steimle JD, Moskowitz IP. TBX5: A Key Regulator of Heart Development. Curr Top Dev Biol. 2017; 122:195-221. PMID: 28057264; PMCID: PMC5371404.
      Citations: 51     Fields:    Translation:HumansAnimals
    18. Burnicka-Turek O, Steimle JD, Huang W, Felker L, Kamp A, Kweon J, Peterson M, Reeves RH, Maslen CL, Gruber PJ, Yang XH, Shendure J, Moskowitz IP. Cilia gene mutations cause atrioventricular septal defects by multiple mechanisms. Hum Mol Genet. 2016 07 15; 25(14):3011-3028. PMID: 27340223; PMCID: PMC5181596.
      Citations: 25     Fields:    Translation:HumansAnimalsCells
    19. Priest JR, Osoegawa K, Mohammed N, Nanda V, Kundu R, Schultz K, Lammer EJ, Girirajan S, Scheetz T, Waggott D, Haddad F, Reddy S, Bernstein D, Burns T, Steimle JD, Yang XH, Moskowitz IP, Hurles M, Lifton RP, Nickerson D, Bamshad M, Eichler EE, Mital S, Sheffield V, Quertermous T, Gelb BD, Portman M, Ashley EA. De Novo and Rare Variants at Multiple Loci Support the Oligogenic Origins of Atrioventricular Septal Heart Defects. PLoS Genet. 2016 Apr; 12(4):e1005963. PMID: 27058611; PMCID: PMC4825975.
      Citations: 46     Fields:    Translation:HumansAnimals
    20. Waldron L, Steimle JD, Greco TM, Gomez NC, Dorr KM, Kweon J, Temple B, Yang XH, Wilczewski CM, Davis IJ, Cristea IM, Moskowitz IP, Conlon FL. The Cardiac TBX5 Interactome Reveals a Chromatin Remodeling Network Essential for Cardiac Septation. Dev Cell. 2016 Feb 08; 36(3):262-75. PMID: 26859351; PMCID: PMC4920128.
      Citations: 40     Fields:    Translation:HumansAnimalsCells
    21. Polk RC, Gergics P, Steimle JD, Li H, Moskowitz IP, Camper SA, Reeves RH. The pattern of congenital heart defects arising from reduced Tbx5 expression is altered in a Down syndrome mouse model. BMC Dev Biol. 2015 Jul 25; 15:30. PMID: 26208718; PMCID: PMC4514943.
      Citations: 7     Fields:    Translation:Animals
    22. Hoffmann AD, Yang XH, Burnicka-Turek O, Bosman JD, Ren X, Steimle JD, Vokes SA, McMahon AP, Kalinichenko VV, Moskowitz IP. Foxf genes integrate tbx5 and hedgehog pathways in the second heart field for cardiac septation. PLoS Genet. 2014 Oct; 10(10):e1004604. PMID: 25356765; PMCID: PMC4214600.
      Citations: 46     Fields:    Translation:HumansAnimalsCells
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