WILLIAMLAGORWILLIAM LAGOR0.000000000000000.000000000000004763LAGOR, WILLIAMProfessorprns:coAuthorOfcoauthor ofprns:endDateend dateFaculty Rankprns:fullNamefull nameprns:grantAwardedBygrant awarded byprns:hasAuthorListauthor listprns:hasFacultyRankhas faculty rankprns:hasNetworkhas networkprns:hasPublicationVenuepublished inprns:informationResourceReferenceinformation resource referenceprns:isPrimaryPositionis primary positionprns:latitudelatitudeprns:longitudelongitudeprns:mainImagephotoprns:maxWeightmaximum weightprns:medlineTAjournal title abbreviationprns:meshDescriptorUIMeSH DescriptorUIprns:meshSemanticGroupNameMeSH semantic group nameprns:minWeightminimum weightprns:numberOfAuthorsnumber of authorsprns:numberOfConnectionsnumber of connectionsprns:numberOfPublicationsnumber of publicationsprns:personIdPerson IDprns:personInPrimaryPositionperson in primary positionprns:physicalNeighborOfphysical neighborprns:positionInDepartmentposition in departmentprns:positionInDivisionposition in divisionprns:predicateNodepredicate nodeprns:principalInvestigatorNameprincipal investigator nameprns:publicationDatepublication dateprns:similarTosimilar toprns:sortOrdersort orderprns:startDatestart dateprns:uniquenessWeightuniqueness weightprns:yearyearAcademic ArticleArticleDocumentbibo:pmidPubMed IdentifierAddressvivo:address1address line 1vivo:addressCitycityvivo:addressPostalCodepostal codevivo:addressStatestate or provinceAgreementvivo:authorInAuthorshipselected publicationsvivo:authorRankauthor rank in publicationAuthorshipDepartmentDivisionGrantvivo:hasResearchArearesearch areasvivo:hasResearcherRoleresearch activitiesvivo:hrJobTitleHR job titleInformation Resourcevivo:linkedAuthorlinked authorvivo:linkedInformationResourcelinked information resourcevivo:mailingAddressmailing addressvivo:personInPositionpositionsPositionvivo:positionInOrganizationposition in organizationvivo:preferredTitlepreferred titleResearcher Rolevivo:researcherRoleOfresearcher role ofRolevivo:roleContributesTocontributes tovivo:sponsorAwardIdsponsor award idrdf:predicatepredicaterdf:typetyperdfs:labellabelConceptAgentfoaf:firstNamefirst namefoaf:lastNamelast nameOrganizationPersonAuthorship 909491Authorship 113153Authorship 536313Authorship 2810736Authorship 2810811726245899Georgiou DK, Dagnino-Acosta A, Lee CS, Griffin DM, Wang H, Lagor WR, Pautler RG, Dirksen RT, Hamilton SLThe Journal of biological chemistryCa2+ Binding/Permeation via Calcium Channel, CaV1.1, Regulates the Intracellular Distribution of the Fatty Acid Transport Protein, CD36, and Fatty Acid Metabolism. J Biol Chem. 2015 Sep 25; 290(39):23751-65.J Biol Chem2015-08-05T00:00:002015Ca2+ Binding/Permeation via Calcium Channel, CaV1.1, Regulates the Intracellular Distribution of the Fatty Acid Transport Protein, CD36, and Fatty Acid Metabolism.26081744Bissig-Choisat B, Wang L, Legras X, Saha PK, Chen L, Bell P, Pankowicz FP, Hill MC, Barzi M, Leyton CK, Leung HE, Kruse RL, Himes RW, Goss JA, Wilson JM, Chan L, Lagor WR, Bissig KDNature communicationsDevelopment and rescue of human familial hypercholesterolaemia in a xenograft mouse model. Nat Commun. 2015 Jun 17; 6:7339.Nat Commun2015-06-17T00:00:002015Development and rescue of human familial hypercholesterolaemia in a xenograft mouse model.Authorship 301041126479315Lagor WR, Tong F, Jarrett KE, Lin W, Conlon DM, Smith M, Wang MY, Yenilmez BO, McCoy MG, Fields DW, O'Neill SM, Gupta R, Kumaravel A, Redon V, Ahima RS, Sturley SL, Billheimer JT, Rader DJNutrition & diabetesDeletion of murine Arv1 results in a lean phenotype with increased energy expenditure. Nutr Diabetes. 2015 Oct 19; 5:e181.Nutr Diabetes2015-10-19T00:00:002015Deletion of murine Arv1 results in a lean phenotype with increased energy expenditure.74Professor10Assistant Professor54Instructor21Chair14Associate Professor3Adjunct Associate Professor6Adjunct ProfessorROSSPOCHEROSS POCHE0.000000000000000.000000000000004843POCHE, ROSSAssociate ProfessorAuthorship 320320526709142Gillard BK, Rodriguez PJ, Fields DW, Raya JL, Lagor WR, Rosales C, Courtney HS, Gotto AM, Pownall HJBiochimica et biophysica actaStreptococcal serum opacity factor promotes cholesterol ester metabolism and bile acid secretion in vitro and in vivo. Biochim Biophys Acta. 2016 Mar; 1861(3):196-204.Biochim Biophys Acta2015-12-18T00:00:002015Streptococcal serum opacity factor promotes cholesterol ester metabolism and bile acid secretion in vitro and in vivo.15147943Osborne AR, Pollock VV, Lagor WR, Ness GCBiochemical and biophysical research communicationsIdentification of insulin-responsive regions in the HMG-CoA reductase promoter. Biochem Biophys Res Commun. 2004 Jun 11; 318(4):814-8.Biochem Biophys Res Commun2004-06-11T00:00:002004Identification of insulin-responsive regions in the HMG-CoA reductase promoter.16127173Lagor WR, de Groh ED, Ness GCThe Journal of biological chemistryDiabetes alters the occupancy of the hepatic 3-hydroxy-3-methylglutaryl-CoA reductase promoter. J Biol Chem. 2005 Nov 04; 280(44):36601-8.J Biol Chem2005-08-26T00:00:002005Diabetes alters the occupancy of the hepatic 3-hydroxy-3-methylglutaryl-CoA reductase promoter.21078838Lagor WR, Rader DJClinical chemistryPhospholipidation of HDL--how much is too much? Clin Chem. 2011 Jan; 57(1):4-6.Clin Chem2010-11-15T00:00:002010Phospholipidation of HDL--how much is too much?One Baylor PlazaHouston, 77030TX22363685Lagor WR, Fields DW, Khetarpal SA, Kumaravel A, Lin W, Weintraub N, Wu K, Hamm-Alvarez SF, Drazul-Schrader D, de la Llera-Moya M, Rothblat GH, Rader DJPloS oneThe effects of apolipoprotein F deficiency on high density lipoprotein cholesterol metabolism in mice. PLoS One. 2012; 7(2):e31616.PLoS One2012-02-20T00:00:002012The effects of apolipoprotein F deficiency on high density lipoprotein cholesterol metabolism in mice.17327468Lagor WR, Heller R, de Groh ED, Ness GCExperimental biology and medicine (Maywood, N.J.)Functional analysis of the hepatic HMG-CoA reductase promoter by in vivo electroporation. Exp Biol Med (Maywood). 2007 Mar; 232(3):353-61.Exp Biol Med (Maywood)2007-03-01T00:00:002007Functional analysis of the hepatic HMG-CoA reductase promoter by in vivo electroporation.19008531Lagor WR, Brown RJ, Toh SA, Millar JS, Fuki IV, de la Llera-Moya M, Yuen T, Rothblat G, Billheimer JT, Rader DJArteriosclerosis, thrombosis, and vascular biologyOverexpression of apolipoprotein F reduces HDL cholesterol levels in vivo. Arterioscler Thromb Vasc Biol. 2009 Jan; 29(1):40-6.Arterioscler Thromb Vasc Biol2008-11-13T00:00:002008Overexpression of apolipoprotein F reduces HDL cholesterol levels in vivo.19280058Niesen MI, Osborne AR, Lagor WR, Zhang H, Kazemfar K, Ness GC, Blanck GActa biochimica et biophysica SinicaTechnological advances in the study of HLA-DRA promoter regulation: extending the functions of CIITA, Oct-1, Rb, and RFX. Acta Biochim Biophys Sin (Shanghai). 2009 Mar; 41(3):198-205.Acta Biochim Biophys Sin (Shanghai)2009-03-01T00:00:002009Technological advances in the study of HLA-DRA promoter regulation: extending the functions of CIITA, Oct-1, Rb, and RFX.19325143Davidson WS, Silva RA, Chantepie S, Lagor WR, Chapman MJ, Kontush AArteriosclerosis, thrombosis, and vascular biologyProteomic analysis of defined HDL subpopulations reveals particle-specific protein clusters: relevance to antioxidative function. Arterioscler Thromb Vasc Biol. 2009 Jun; 29(6):870-6.Arterioscler Thromb Vasc Biol2009-03-26T00:00:002009Proteomic analysis of defined HDL subpopulations reveals particle-specific protein clusters: relevance to antioxidative function.Authorship 6524432627270415Palmer EE, Jarrett KE, Sachdev RK, Al Zahrani F, Hashem MO, Ibrahim N, Sampaio H, Kandula T, Macintosh R, Gupta R, Conlon DM, Billheimer JT, Rader DJ, Funato K, Walkey CJ, Lee CS, Loo C, Brammah S, Elakis G, Zhu Y, Buckley M, Kirk EP, Bye A, Alkuraya FS, Roscioli T, Lagor WRHuman molecular geneticsNeuronal deficiency of ARV1 causes an autosomal recessive epileptic encephalopathy. Hum Mol Genet. 2016 07 15; 25(14):3042-3054.Hum Mol Genet2016-06-06T00:00:002016Neuronal deficiency of ARV1 causes an autosomal recessive epileptic encephalopathy.Authorship 677987528137768Kuwano T, Bi X, Cipollari E, Yasuda T, Lagor WR, Szapary HJ, Tohyama J, Millar JS, Billheimer JT, Lyssenko NN, Rader DJJournal of lipid researchOverexpression and deletion of phospholipid transfer protein reduce HDL mass and cholesterol efflux capacity but not macrophage reverse cholesterol transport. J Lipid Res. 2017 04; 58(4):731-741.J Lipid Res2017-01-30T00:00:002017Overexpression and deletion of phospholipid transfer protein reduce HDL mass and cholesterol efflux capacity but not macrophage reverse cholesterol transport.21084752Burkhardt R, Toh SA, Lagor WR, Birkeland A, Levin M, Li X, Robblee M, Fedorov VD, Yamamoto M, Satoh T, Akira S, Kathiresan S, Breslow JL, Rader DJThe Journal of clinical investigationTrib1 is a lipid- and myocardial infarction-associated gene that regulates hepatic lipogenesis and VLDL production in mice. J Clin Invest. 2010 Dec; 120(12):4410-4.J Clin Invest2010-11-15T00:00:002010Trib1 is a lipid- and myocardial infarction-associated gene that regulates hepatic lipogenesis and VLDL production in mice.21296681Nijstad N, de Boer JF, Lagor WR, Toelle M, Usher D, Annema W, der Giet Mv, Rader DJ, Tietge UJBiochimica et biophysica actaOverexpression of apolipoprotein O does not impact on plasma HDL levels or functionality in human apolipoprotein A-I transgenic mice. Biochim Biophys Acta. 2011 Apr; 1811(4):294-9.Biochim Biophys Acta2011-02-03T00:00:002011Overexpression of apolipoprotein O does not impact on plasma HDL levels or functionality in human apolipoprotein A-I transgenic mice.22985273Kassim SH, Li H, Bell P, Somanathan S, Lagor W, Jacobs F, Billheimer J, Wilson JM, Rader DJHuman gene therapyAdeno-associated virus serotype 8 gene therapy leads to significant lowering of plasma cholesterol levels in humanized mouse models of homozygous and heterozygous familial hypercholesterolemia. Hum Gene Ther. 2013 Jan; 24(1):19-26.Hum Gene Ther2012-11-14T00:00:002012Adeno-associated virus serotype 8 gene therapy leads to significant lowering of plasma cholesterol levels in humanized mouse models of homozygous and heterozygous familial hypercholesterolemia.MARCODE GIORGIMARCO DE GIORGI12815DE GIORGI, MARCOInstructorAuthorship 8406151428300165Jarrett KE, Lee CM, Yeh YH, Hsu RH, Gupta R, Zhang M, Rodriguez PJ, Lee CS, Gillard BK, Bissig KD, Pownall HJ, Martin JF, Bao G, Lagor WRScientific reportsSomatic genome editing with CRISPR/Cas9 generates and corrects a metabolic disease. Sci Rep. 2017 03 16; 7:44624.Sci Rep2017-03-16T00:00:002017Somatic genome editing with CRISPR/Cas9 generates and corrects a metabolic disease.Authorship 8683691528337975Lee CS, Hanna AD, Wang H, Dagnino-Acosta A, Joshi AD, Knoblauch M, Xia Y, Georgiou DK, Xu J, Long C, Amano H, Reynolds C, Dong K, Martin JC, Lagor WR, Rodney GG, Sahin E, Sewry C, Hamilton SLNature communicationsA chemical chaperone improves muscle function in mice with a RyR1 mutation. Nat Commun. 2017 03 24; 8:14659.Nat Commun2017-03-24T00:00:002017A chemical chaperone improves muscle function in mice with a RyR1 mutation.Authorship 869599328487442Pankowicz FP, Jarrett KE, Lagor WR, Bissig KDGutCRISPR/Cas9: at the cutting edge of hepatology. Gut. 2017 07; 66(7):1329-1340.Gut2017-05-09T00:00:002017CRISPR/Cas9: at the cutting edge of hepatology.20558822Brown RJ, Lagor WR, Sankaranaravanan S, Yasuda T, Quertermous T, Rothblat GH, Rader DJCirculation researchImpact of combined deficiency of hepatic lipase and endothelial lipase on the metabolism of both high-density lipoproteins and apolipoprotein B-containing lipoproteins. Circ Res. 2010 Aug 06; 107(3):357-64.Circ Res2010-06-17T00:00:002010Impact of combined deficiency of hepatic lipase and endothelial lipase on the metabolism of both high-density lipoproteins and apolipoprotein B-containing lipoproteins.21605865Boone LR, Lagor WR, Moya Mde L, Niesen MI, Rothblat GH, Ness GCAtherosclerosisThyroid hormone enhances the ability of serum to accept cellular cholesterol via the ABCA1 transporter. Atherosclerosis. 2011 Sep; 218(1):77-82.Atherosclerosis2011-05-06T00:00:002011Thyroid hormone enhances the ability of serum to accept cellular cholesterol via the ABCA1 transporter.Authorship 8799022Authorship 8856751628974517Musunuru K, Lagor WR, Miano JMCirculation. Cardiovascular geneticsWhat Do We Really Think About Human Germline Genome Editing, and What Does It Mean for Medicine? Circ Cardiovasc Genet. 2017 10; 10(5).Circ Cardiovasc Genet2017-10-01T00:00:002017What Do We Really Think About Human Germline Genome Editing, and What Does It Mean for Medicine?29670083Wang C, He Y, Xu P, Yang Y, Saito K, Xia Y, Yan X, Hinton A, Yan C, Ding H, Yu L, Shu G, Gupta R, Wu Q, Tong Q, Lagor WR, Flores ER, Xu YNature communicationsTAp63 contributes to sexual dimorphism in POMC neuron functions and energy homeostasis. Nat Commun. 2018 04 18; 9(1):1544.Nat Commun2018-04-18T00:00:002018TAp63 contributes to sexual dimorphism in POMC neuron functions and energy homeostasis.D008099Anatomy92029630.482513LiverD000229Living Beings741350.904673DependovirusAuthorship 91684610Authorship 9204487Authorship 9380289Authorship 93967712Authorship 9401631330026278Jarrett KE, Lee C, De Giorgi M, Hurley A, Gillard BK, Doerfler AM, Li A, Pownall HJ, Bao G, Lagor WRArteriosclerosis, thrombosis, and vascular biologySomatic Editing of Ldlr With Adeno-Associated Viral-CRISPR Is an Efficient Tool for Atherosclerosis Research. Arterioscler Thromb Vasc Biol. 2018 09; 38(9):1997-2006.Arterioscler Thromb Vasc Biol2018-09-01T00:00:002018Somatic Editing of Ldlr With Adeno-Associated Viral-CRISPR Is an Efficient Tool for Atherosclerosis Research.30170115Pankowicz FP, Barzi M, Kim KH, Legras X, Martins CS, Wooton-Kee CR, Lagor WR, Marini JC, Elsea SH, Bissig-Choisat B, Moore DD, Bissig KDGastroenterologyRapid Disruption of Genes Specifically in Livers of Mice Using Multiplex CRISPR/Cas9 Editing. Gastroenterology. 2018 12; 155(6):1967-1970.e6.Gastroenterology2018-08-28T00:00:002018Rapid Disruption of Genes Specifically in Livers of Mice Using Multiplex CRISPR/Cas9 Editing.30355031Pan X, Philippen L, Lahiri SK, Lee C, Park SH, Word TA, Li N, Jarrett KE, Gupta R, Reynolds JO, Lin J, Bao G, Lagor WR, Wehrens XHTCirculation researchIn Vivo Ryr2 Editing Corrects Catecholaminergic Polymorphic Ventricular Tachycardia. Circ Res. 2018 Sep 28; 123(8):953-963.Circ Res2018-09-28T00:00:002018In Vivo Ryr2 Editing Corrects Catecholaminergic Polymorphic Ventricular Tachycardia.30582449Ni L, Scott L, Campbell HM, Pan X, Alsina KM, Reynolds J, Philippen LE, Hulsurkar M, Lagor WR, Li N, Wehrens XHTCirculation researchAtrial-Specific Gene Delivery Using an Adeno-Associated Viral Vector. Circ Res. 2019 01 18; 124(2):256-262.Circ Res2019-01-18T00:00:002019Atrial-Specific Gene Delivery Using an Adeno-Associated Viral Vector.30619914Li A, Lee CM, Hurley AE, Jarrett KE, De Giorgi M, Lu W, Balderrama KS, Doerfler AM, Deshmukh H, Ray A, Bao G, Lagor WRMolecular therapy. Methods & clinical developmentA Self-Deleting AAV-CRISPR System for In?Vivo Genome Editing. Mol Ther Methods Clin Dev. 2019 Mar 15; 12:111-122.Mol Ther Methods Clin Dev2018-12-06T00:00:002018A Self-Deleting AAV-CRISPR System for In?Vivo Genome Editing.Authorship 10849112024-07-31NIHDICKINSON, MARY E;HEANEY, JASON D ;LAGOR, WILLIAM RAYMOND2018-09-18BCM-Rice resource for the analysis of somatic gene editing in miceU42OD0266452026-03-31NIHLAGOR, WILLIAM RAYMOND2016-12-20Genetic Repair of Familial HypercholesterolemiaR01HL132840Principal InvestigatorCo-Principal InvestigatorDepartment of MedicineDepartment of Molecular & Cellular BiologyMedicine-Athero & LipoproteinsMolecular & Cellular BiologyMolecular Physiology & BiophysicsBaylor College of MedicineFRANKHORRIGANFRANK HORRIGAN0.000000000000000.000000000000001467HORRIGAN, FRANKAssociate ProfessorKIRILLLARINKIRILL LARIN0.000000000000000.000000000000001845LARIN, KIRILLAdjunct ProfessorCHRISTIEBALLANTYNECHRISTIE BALLANTYNE29.70978600000000-95.399866000000002252BALLANTYNE, CHRISTIEProfessorKARL-DIMITERBISSIGKARL-DIMITER BISSIG0.000000000000000.000000000000001893BISSIG, KARL-DIMITERAdjunct Associate ProfessorSTEENPEDERSENSTEEN PEDERSEN0.000000000000000.000000000000003303PEDERSEN, STEENAssistant ProfessorGEORGERODNEY JR.GEORGE RODNEY JR.0.000000000000000.000000000000002192RODNEY JR., GEORGEAssociate ProfessorERICBOERWINKLEERIC BOERWINKLE0.000000000000000.000000000000002653BOERWINKLE, ERICAdjunct ProfessorSALIMVIRANISALIM VIRANI29.70978600000000-95.399866000000003676VIRANI, SALIMAdjunct ProfessorSUSANHAMILTONSUSAN HAMILTON0.000000000000000.0000000000000028HAMILTON, SUSANProfessor3.715230.00749238302research areas5.025140.034006945coauthor of117.0879.255760similar to1163selected publicationsVIJAYNAMBIVIJAY NAMBI29.70978600000000-95.39986600000000609NAMBI, VIJAYProfessorXANDERWEHRENSXANDER WEHRENS0.000000000000000.00000000000000964WEHRENS, XANDERProfessorAuthorship 942879230893109Furgurson M, Lagor WRCurrent opinion in lipidologyCRISPR: a promising tool for lipid physiology and therapeutics. Curr Opin Lipidol. 2019 06; 30(3):172-176.Curr Opin Lipidol2019-06-01T00:00:002019CRISPR: a promising tool for lipid physiology and therapeutics.Authorship 946273231049151De Giorgi M, Lagor WRMethodist DeBakey cardiovascular journalGene Delivery in Lipid Research and Therapies. Methodist Debakey Cardiovasc J. 2019 Jan-Mar; 15(1):62-69.Methodist Debakey Cardiovasc J2019-01-01T00:00:002019Gene Delivery in Lipid Research and Therapies.Authorship 1272381D0000726691402030.826997Gene EditingD064112Chemicals & DrugsGenes & Molecular Sequences65830.902518Clustered Regularly Interspaced Short Palindromic RepeatsD064113Physiology2103110.778874CRISPR-Cas Systems23912992Lagor WR, Johnston JC, Lock M, Vandenberghe LH, Rader DJMethods in molecular biology (Clifton, N.J.)Adeno-associated viruses as liver-directed gene delivery vehicles: focus on lipoprotein metabolism. Methods Mol Biol. 2013; 1027:273-307.Methods Mol Biol2013-01-01T00:00:002013Adeno-associated viruses as liver-directed gene delivery vehicles: focus on lipoprotein metabolism.Authorship 952871631356139Fan Q, Mao H, Angelini A, Coarfa C, Robertson MJ, Lagor WR, Wehrens XHT, Martin JF, Pi X, Xie LCirculationDepletion of Endothelial Prolyl Hydroxylase Domain Protein 2 and 3 Promotes Cardiomyocyte Proliferation and Prevents Ventricular Failure Induced by Myocardial Infarction. Circulation. 2019 07 30; 140(5):440-442.Circulation2019-07-29T00:00:002019Depletion of Endothelial Prolyl Hydroxylase Domain Protein 2 and 3 Promotes Cardiomyocyte Proliferation and Prevents Ventricular Failure Induced by Myocardial Infarction.2022-07-31NIHBAO, GANG2019-09-01Velcro AAV Vector for tissue-specific delivery of genome editing reagents with enhanced cargo capacityUG3HL151545Co-Principal InvestigatorAuthorship 957343731619061Lian Z, Perrard XD, Peng X, Raya JL, Hernandez AA, Johnson CG, Lagor WR, Pownall HJ, Hoogeveen RC, Simon SI, Sacks FM, Ballantyne CM, Wu HArteriosclerosis, thrombosis, and vascular biologyReplacing Saturated Fat With Unsaturated Fat in Western Diet Reduces Foamy Monocytes and Atherosclerosis in Male Ldlr-/- Mice. Arterioscler Thromb Vasc Biol. 2020 01; 40(1):72-85.Arterioscler Thromb Vasc Biol2019-10-17T00:00:002019Replacing Saturated Fat With Unsaturated Fat in Western Diet Reduces Foamy Monocytes and Atherosclerosis in Male Ldlr-/- Mice.CHRISTOPHERWALKEYCHRISTOPHER WALKEY15266WALKEY, CHRISTOPHERInstructorAuthorship 1094835Authorship 978062332073405Doerfler AM, Walkey CJ, Lagor WRCurrent opinion in cardiologyRecent advances in genome editing for cardiovascular disease. Curr Opin Cardiol. 2020 05; 35(3):242-248.Curr Opin Cardiol2020-05-01T00:00:002020Recent advances in genome editing for cardiovascular disease.Authorship 9795171632197071Li Z, Votava JA, Zajac GJM, Nguyen JN, Leyva Jaimes FB, Ly SM, Brinkman JA, De Giorgi M, Kaul S, Green CL, St Clair SL, Belisle SL, Rios JM, Nelson DW, Sorci-Thomas MG, Lagor WR, Lamming DW, Eric Yen CL, Parks BWCell metabolismIntegrating Mouse and Human Genetic Data to Move beyond GWAS and Identify Causal Genes in Cholesterol Metabolism. Cell Metab. 2020 04 07; 31(4):741-754.e5.Cell Metab2020-03-19T00:00:002020Integrating Mouse and Human Genetic Data to Move beyond GWAS and Identify Causal Genes in Cholesterol Metabolism.true1Adjunct ProfessorAdjunct Professor2024-02-29NIHLAGOR, WILLIAM RAYMOND2020-04-06Physiological Dissection of the Mevalonate PathwayR01DK124477Principal InvestigatorAuthorship 9883311132348718Li A, Tanner MR, Lee CM, Hurley AE, De Giorgi M, Jarrett KE, Davis TH, Doerfler AM, Bao G, Beeton C, Lagor WRMolecular therapy : the journal of the American Society of Gene TherapyAAV-CRISPR Gene Editing Is Negated by Pre-existing Immunity to Cas9. Mol Ther. 2020 Jun 03; 28(6):1432-1441.Mol Ther2020-04-19T00:00:002020AAV-CRISPR Gene Editing Is Negated by Pre-existing Immunity to Cas9.Authorship 9896811432424153Pastore N, Huynh T, Herz NJ, Calcagni' A, Klisch TJ, Brunetti L, Kim KH, De Giorgi M, Hurley A, Carissimo A, Mutarelli M, Aleksieva N, D'Orsi L, Lagor WR, Moore DD, Settembre C, Finegold MJ, Forbes SJ, Ballabio ANature communicationsTFEB regulates murine liver cell fate during development and regeneration. Nat Commun. 2020 05 18; 11(1):2461.Nat Commun2020-05-18T00:00:002020TFEB regulates murine liver cell fate during development and regeneration.Authorship 10035941233109681De Giorgi M, Jarrett KE, Burton JC, Doerfler AM, Hurley A, Li A, Hsu RH, Furgurson M, Patel KR, Han J, Borchers CH, Lagor WRJournal of lipid researchDepletion of essential isoprenoids and ER stress induction following acute liver-specific deletion of HMG-CoA reductase. J Lipid Res. 2020 12; 61(12):1675-1686.J Lipid Res2020-10-27T00:00:002020Depletion of essential isoprenoids and ER stress induction following acute liver-specific deletion of HMG-CoA reductase.Authorship 10151864233828315Saha K, Sontheimer EJ, Brooks PJ, Dwinell MR, Gersbach CA, Liu DR, Murray SA, Tsai SQ, Wilson RC, Anderson DG, Asokan A, Banfield JF, Bankiewicz KS, Bao G, Bulte JWM, Bursac N, Campbell JM, Carlson DF, Chaikof EL, Chen ZY, Cheng RH, Clark KJ, Curiel DT, Dahlman JE, Deverman BE, Dickinson ME, Doudna JA, Ekker SC, Emborg ME, Feng G, Freedman BS, Gamm DM, Gao G, Ghiran IC, Glazer PM, Gong S, Heaney JD, Hennebold JD, Hinson JT, Khvorova A, Kiani S, Lagor WR, Lam KS, Leong KW, Levine JE, Lewis JA, Lutz CM, Ly DH, Maragh S, McCray PB, McDevitt TC, Mirochnitchenko O, Morizane R, Murthy N, Prather RS, Ronald JA, Roy S, Roy S, Sabbisetti V, Saltzman WM, Santangelo PJ, Segal DJ, Shimoyama M, Skala MC, Tarantal AF, Tilton JC, Truskey GA, Vandsburger M, Watts JK, Wells KD, Wolfe SA, Xu Q, Xue W, Yi G, Zhou J, SCGE ConsortiumNatureThe NIH Somatic Cell Genome Editing program. Nature. 2021 04; 592(7853):195-204.Nature2021-04-07T00:00:002021The NIH Somatic Cell Genome Editing program.Authorship 10193751334036256Bissig-Choisat B, Alves-Bezerra M, Zorman B, Ochsner SA, Barzi M, Legras X, Yang D, Borowiak M, Dean AM, York RB, Galvan NTN, Goss J, Lagor WR, Moore DD, Cohen DE, McKenna NJ, Sumazin P, Bissig KDJHEP reports : innovation in hepatologyA human liver chimeric mouse model for non-alcoholic fatty liver disease. JHEP Rep. 2021 Jun; 3(3):100281.JHEP Rep2021-03-21T00:00:002021A human liver chimeric mouse model for non-alcoholic fatty liver disease.Authorship 10213721234141821De Giorgi M, Li A, Hurley A, Barzi M, Doerfler AM, Cherayil NA, Smith HE, Brown JD, Lin CY, Bissig KD, Bao G, Lagor WRMolecular therapy. Methods & clinical developmentTargeting the Apoa1 locus for liver-directed gene therapy. Mol Ther Methods Clin Dev. 2021 Jun 11; 21:656-669.Mol Ther Methods Clin Dev2021-04-24T00:00:002021Targeting the Apoa1 locus for liver-directed gene therapy.Authorship 1032359734695545Liang SQ, Walkey CJ, Martinez AE, Su Q, Dickinson ME, Wang D, Lagor WR, Heaney JD, Gao G, Xue WMolecular therapy : the journal of the American Society of Gene TherapyAAV5 delivery of CRISPR-Cas9 supports effective genome editing in mouse lung airway. Mol Ther. 2022 Jan 05; 30(1):238-243.Mol Ther2021-10-23T00:00:002021AAV5 delivery of CRISPR-Cas9 supports effective genome editing in mouse lung airway.Authorship 10353801Authorship 10354469Authorship 1035757634895501Lagor WRMolecular therapy : the journal of the American Society of Gene TherapyAnti-Cas9 immunity: A formidable challenge for muscle genome editing. Mol Ther. 2022 01 05; 30(1):10-12.Mol Ther2021-12-11T00:00:002021Anti-Cas9 immunity: A formidable challenge for muscle genome editing.34901307Schneller JL, Lee CM, Venturoni LE, Chandler RJ, Li A, Myung S, Cradick TJ, Hurley AE, Lagor WR, Bao G, Venditti CPMolecular therapy. Methods & clinical developmentIn?vivo genome editing at the albumin locus to treat methylmalonic acidemia. Mol Ther Methods Clin Dev. 2021 Dec 10; 23:619-632.Mol Ther Methods Clin Dev2021-11-11T00:00:002021In?vivo genome editing at the albumin locus to treat methylmalonic acidemia.34929174Yamaguchi H, Kitami M, Uchima Koecklin KH, He L, Wang J, Lagor WR, Perrien DS, Komatsu YDevelopmental biologyTemporospatial regulation of intraflagellar transport is required for the endochondral ossification in mice. Dev Biol. 2022 02; 482:91-100.Dev Biol2021-12-17T00:00:002021Temporospatial regulation of intraflagellar transport is required for the endochondral ossification in mice.Authorship 104063118Authorship 10412682Authorship 1041363435230602Hurley A, Lagor WRCurrent atherosclerosis reportsTreating Cardiovascular Disease with Liver Genome Engineering. Curr Atheroscler Rep. 2022 02; 24(2):75-84.Curr Atheroscler Rep2022-03-01T00:00:002022Treating Cardiovascular Disease with Liver Genome Engineering.35172604Doerfler AM, Han J, Jarrett KE, Tang L, Jain A, Saltzman A, De Giorgi M, Chuecos M, Hurley AE, Li A, Morand P, Ayala C, Goodlett DR, Malovannaya A, Martin JF, de Aguiar Vallim TQ, Shroyer N, Lagor WRArteriosclerosis, thrombosis, and vascular biologyIntestinal Deletion of 3-Hydroxy-3-Methylglutaryl-Coenzyme A Reductase Promotes Expansion of the Resident Stem Cell Compartment. Arterioscler Thromb Vasc Biol. 2022 04; 42(4):381-394.Arterioscler Thromb Vasc Biol2022-02-17T00:00:002022Intestinal Deletion of 3-Hydroxy-3-Methylglutaryl-Coenzyme A Reductase Promotes Expansion of the Resident Stem Cell Compartment.35237996De Giorgi M, Jarrett KE, de Aguiar Vallim TQ, Lagor WRMethods in molecular biology (Clifton, N.J.)In Vivo Gene Editing in Lipid and Atherosclerosis Research. Methods Mol Biol. 2022; 2419:673-713.Methods Mol Biol2022-01-01T00:00:002022In Vivo Gene Editing in Lipid and Atherosclerosis Research.Authorship 152872true1ProfessorProfessortrue1Assistant ProfessorAssistant Professortrue1Associate ProfessorAssociate Professortrue1InstructorInstructortrue1Associate ProfessorAssociate Professortrue1ProfessorProfessortrue1Associate ProfessorAssociate Professortrue1Adjunct ProfessorAdjunct ProfessorDepartment of Integrative Physiologytrue1InstructorInstructortrue1ProfessorProfessorAuthorship 1207971Authorship 10624809Authorship 10573501536587560Lorincz R, Alvarez AB, Walkey CJ, Mendon?a SA, Lu ZH, Martinez AE, Ljungberg C, Heaney JD, Lagor WR, Curiel DTBiomedicine & pharmacotherapy = Biomedecine & pharmacotherapieIn vivo editing of the pan-endothelium by immunity evading simian adenoviral vector. Biomed Pharmacother. 2023 Feb; 158:114189.Biomed Pharmacother2022-12-30T00:00:002022In vivo editing of the pan-endothelium by immunity evading simian adenoviral vector.36381302Doerfler AM, Park SH, Assini JM, Youssef A, Saxena L, Yaseen AB, De Giorgi M, Chuecos M, Hurley AE, Li A, Marcovina SM, Bao G, Boffa MB, Koschinsky ML, Lagor WRMolecular therapy. Methods & clinical developmentLPA disruption with AAV-CRISPR potently lowers plasma apo(a) in transgenic mouse model: A proof-of-concept study. Mol Ther Methods Clin Dev. 2022 Dec 08; 27:337-351.Mol Ther Methods Clin Dev2022-10-13T00:00:002022LPA disruption with AAV-CRISPR potently lowers plasma apo(a) in transgenic mouse model: A proof-of-concept study.true1Adjunct ProfessorAdjunct ProfessorAuthorship 10677082Authorship 106864318Authorship 1067943737065676Walkey CJ, Lagor WRThe journal of cardiovascular agingCaMKIId gene editing- A base hit for the heart. J Cardiovasc Aging. 2023; 3(2).J Cardiovasc Aging2023-03-22T00:00:002023CaMKIId gene editing- A base hit for the heart.37040361Wang Y, Hurley A, De Giorgi M, Tanner MR, Hu RC, Pennington MW, Lagor WR, Beeton CPloS oneAdeno-Associated virus 8 delivers an immunomodulatory peptide to mouse liver more efficiently than to rat liver. PLoS One. 2023; 18(4):e0283996.PLoS One2023-04-11T00:00:002023Adeno-Associated virus 8 delivers an immunomodulatory peptide to mouse liver more efficiently than to rat liver.37075130Barzi M, Johnson CG, Chen T, Rodriguiz RM, Hemmingsen M, Gonzalez TJ, Rosales A, Beasley J, Peck CK, Ma Y, Stiles AR, Wood TC, Maeso-Diaz R, Diehl AM, Young SP, Everitt JI, Wetsel WC, Lagor WR, Bissig-Choisat B, Asokan A, El-Gharbawy A, Bissig KDScience translational medicineRescue of glutaric aciduria type I in mice by liver-directed therapies. Sci Transl Med. 2023 04 19; 15(692):eadf4086.Sci Transl Med2023-04-19T00:00:002023Rescue of glutaric aciduria type I in mice by liver-directed therapies.Authorship 107404412Authorship 1073991237290980Assini JM, Clark JR, Youssef A, Xing C, Doerfler AM, Park SH, Saxena L, Yaseen AB, B?ren J, Gros R, Bao G, Lagor WR, Boffa MB, Koschinsky MLAtherosclerosisHigh levels of lipoprotein(a) in transgenic mice exacerbate atherosclerosis and promote vulnerable plaque features in a sex-specific manner. Atherosclerosis. 2023 11; 384:117150.Atherosclerosis2023-05-30T00:00:002023High levels of lipoprotein(a) in transgenic mice exacerbate atherosclerosis and promote vulnerable plaque features in a sex-specific manner.37254440Chuecos MA, Lagor WRJournal of inherited metabolic diseaseLiver directed adeno-associated viral vectors to treat metabolic disease. J Inherit Metab Dis. 2024 Jan; 47(1):22-40.J Inherit Metab Dis2023-06-05T00:00:002023Liver directed adeno-associated viral vectors to treat metabolic disease.Authorship 10750771537467291Huang Q, Chen AT, Chan KY, Sorensen H, Barry AJ, Azari B, Zheng Q, Beddow T, Zhao B, Tobey IG, Moncada-Reid C, Eid FE, Walkey CJ, Ljungberg MC, Lagor WR, Heaney JD, Chan YA, Deverman BEPLoS biologyTargeting AAV vectors to the central nervous system by engineering capsid-receptor interactions that enable crossing of the blood-brain barrier. PLoS Biol. 2023 07; 21(7):e3002112.PLoS Biol2023-07-19T00:00:002023Targeting AAV vectors to the central nervous system by engineering capsid-receptor interactions that enable crossing of the blood-brain barrier.true1ProfessorProfessorAuthorship 194571true1ProfessorProfessorAuthorship 107940327Authorship 10776101637546995De Giorgi M, Park SH, Castoreno A, Cao M, Hurley A, Saxena L, Chuecos MA, Walkey CJ, Doerfler AM, Furgurson MN, Ljungberg MC, Patel KR, Hyde S, Chickering T, Lefebvre S, Wassarman K, Miller P, Qin J, Schlegel MK, Zlatev I, Li RG, Kim J, Martin JF, Bissig KD, Jadhav V, Bao G, Lagor WRbioRxiv : the preprint server for biologyIn vivo expansion of gene-targeted hepatocytes through transient inhibition of an essential gene. bioRxiv. 2023 Jul 29.bioRxiv2023-07-29T00:00:002023In vivo expansion of gene-targeted hepatocytes through transient inhibition of an essential gene.37709832Lee CS, Jung SY, Yee RSZ, Agha NH, Hong J, Chang T, Babcock LW, Fleischman JD, Clayton B, Hanna AD, Ward CS, Lanza D, Hurley AE, Zhang P, Wehrens XHT, Lagor WR, Rodney GG, Hamilton SLCommunications biologySpeg interactions that regulate the stability of excitation-contraction coupling protein complexes in triads and dyads. Commun Biol. 2023 09 14; 6(1):942.Commun Biol2023-09-14T00:00:002023Speg interactions that regulate the stability of excitation-contraction coupling protein complexes in triads and dyads.true1Adjunct Associate ProfessorAdjunct Associate ProfessorAuthorship 10904521338464671Moore OM, Aguilar-Sanchez Y, Lahiri SK, Hulsurkar MM, Alberto Navarro-Garcia J, Word TA, Keefe JA, Barazi D, Munivez EM, Moore CT, Parthasarathy V, Davidson J, Lagor WR, Park SH, Bao G, Miyake CY, Wehrens XHTThe journal of cardiovascular agingLong-term efficacy and safety of cardiac genome editing for catecholaminergic polymorphic ventricular tachycardia. J Cardiovasc Aging. 2024 Jan; 4(1).J Cardiovasc Aging2024-01-04T00:00:002024Long-term efficacy and safety of cardiac genome editing for catecholaminergic polymorphic ventricular tachycardia.Authorship 238103Authorship 141344124529150Lagor WR, Fields DW, Bauer RC, Crawford A, Abt MC, Artis D, Wherry EJ, Rader DJAtherosclerosisGenetic manipulation of the ApoF/Stat2 locus supports an important role for type I interferon signaling in atherosclerosis. Atherosclerosis. 2014 Mar; 233(1):234-41.Atherosclerosis2014-01-10T00:00:002014Genetic manipulation of the ApoF/Stat2 locus supports an important role for type I interferon signaling in atherosclerosis.Authorship 1469093Authorship 146995724777581Yang Y, Kuwano T, Lagor WR, Albert CJ, Brenton S, Rader DJ, Ford DA, Brown RJLipidsLipidomic analyses of female mice lacking hepatic lipase and endothelial lipase indicate selective modulation of plasma lipid species. Lipids. 2014 Jun; 49(6):505-15.Lipids2014-04-29T00:00:002014Lipidomic analyses of female mice lacking hepatic lipase and endothelial lipase indicate selective modulation of plasma lipid species.24830434O'Neill SM, Hinkle C, Chen SJ, Sandhu A, Hovhannisyan R, Stephan S, Lagor WR, Ahima RS, Johnston JC, Reilly MPGene therapyTargeting adipose tissue via systemic gene therapy. Gene Ther. 2014 Jul; 21(7):653-61.Gene Ther2014-05-15T00:00:002014Targeting adipose tissue via systemic gene therapy.Authorship 48741Authorship 521993Authorship 838034Authorship 93652