TORSAVIDGETOR SAVIDGE0.000000000000000.000000000000004547SAVIDGE, TORProfessorplugins:FeaturedVideosFeatured Videosprns:coAuthorOfcoauthor ofprns:endDateend dateFaculty Rankprns:fullNamefull nameprns:grantAwardedBygrant awarded byprns:hasAuthorListauthor listprns:hasFacultyRankhas faculty rankprns:hasNetworkhas networkprns:hasPublicationVenuepublished inprns:informationResourceReferenceinformation resource referenceprns:isPrimaryPositionis primary positionprns:latitudelatitudeprns:longitudelongitudeprns:mainImagephotoprns:maxWeightmaximum weightprns:medlineTAjournal title abbreviationprns:meshDescriptorUIMeSH DescriptorUIprns:meshSemanticGroupNameMeSH semantic group nameprns:minWeightminimum weightprns:numberOfAuthorsnumber of authorsprns:numberOfConnectionsnumber of connectionsprns:numberOfPublicationsnumber of publicationsprns:personIdPerson IDprns:personInPrimaryPositionperson in primary positionprns:physicalNeighborOfphysical neighborprns:pluginSearchableDataProfilesRNS Plugin Searchable Dataprns:positionInDepartmentposition in departmentprns:positionInDivisionposition in divisionprns:predicateNodepredicate nodeprns:principalInvestigatorNameprincipal investigator nameprns:publicationDatepublication dateprns:similarTosimilar toprns:sortOrdersort orderprns:startDatestart dateprns:uniquenessWeightuniqueness weightprns:yearyearAcademic ArticleArticleDocumentbibo:pmidPubMed IdentifierAddressvivo:address1address line 1vivo:addressCitycityvivo:addressPostalCodepostal codevivo:addressStatestate or provinceAgreementvivo:authorInAuthorshipselected publicationsvivo:authorRankauthor rank in publicationAuthorshipDepartmentDivisionGrantvivo:hasResearchArearesearch areasvivo:hasResearcherRoleresearch activitiesvivo:hrJobTitleHR job titleInformation Resourcevivo:linkAnchorTextlink anchor textvivo:linkedAuthorlinked authorvivo:linkedInformationResourcelinked information resourcevivo:mailingAddressmailing addressvivo:personInPositionpositionsPositionvivo:positionInOrganizationposition in organizationvivo:preferredTitlepreferred titleResearcher Rolevivo:researcherRoleOfresearcher role ofRolevivo:roleContributesTocontributes tovivo:sponsorAwardIdsponsor award idURLLinkvivo:webpagewebpagerdf:predicatepredicaterdf:typetyperdfs:labellabelConceptAgentfoaf:firstNamefirst namefoaf:lastNamelast nameOrganizationPerson25404692Joffr? E, von Mentzer A, Abd El Ghany M, Oezguen N, Savidge T, Dougan G, Svennerholm AM, Sj?ling ?Journal of bacteriologyAllele variants of enterotoxigenic Escherichia coli heat-labile toxin are globally transmitted and associated with colonization factors. J Bacteriol. 2015 Jan; 197(2):392-403.J Bacteriol2014-11-17T00:00:002014Allele variants of enterotoxigenic Escherichia coli heat-labile toxin are globally transmitted and associated with colonization factors.Authorship 801763Authorship 787832Authorship 820846Authorship 847965Authorship 868234Authorship 885971Authorship 910346Authorship 944132Authorship 984302Authorship 1010441Authorship 10395010Authorship 1101841Authorship 1159078Authorship 1190254Authorship 139973Authorship 1607641Authorship 1615419Authorship 162283925108170Savidge TCCurrent opinion in pharmacologyImportance of NO and its related compounds in enteric nervous system regulation of gut homeostasis and disease susceptibility. Curr Opin Pharmacol. 2014 Dec; 19:54-60.Curr Opin Pharmacol2014-08-07T00:00:002014Importance of NO and its related compounds in enteric nervous system regulation of gut homeostasis and disease susceptibility.25404023Li S, Shi L, Yang Z, Zhang Y, Perez-Cordon G, Huang T, Ramsey J, Oezguen N, Savidge TC, Feng HInfection and immunityCritical roles of Clostridium difficile toxin B enzymatic activities in pathogenesis. Infect Immun. 2015 Feb; 83(2):502-13.Infect Immun2014-11-17T00:00:002014Critical roles of Clostridium difficile toxin B enzymatic activities in pathogenesis.25885671Yu H, Chen K, Wu J, Yang Z, Shi L, Barlow LL, Aronoff DM, Garey KW, Savidge TC, von Rosenvinge EC, Kelly CP, Feng HPloS oneIdentification of toxemia in patients with Clostridium difficile infection. PLoS One. 2015; 10(4):e0124235.PLoS One2015-04-17T00:00:002015Identification of toxemia in patients with Clostridium difficile infection.Authorship 263633Authorship 347321Authorship 435103Authorship 477871Authorship 509611Authorship 538981Authorship 573118Authorship 700732Authorship 774091Authorship 880952Authorship 923281Authorship 982717622011Savidge TC, Morey AL, Ferguson DJ, Fleming KA, Shmakov AN, Phillips ADDifferentiation; research in biological diversityHuman intestinal development in a severe-combined immunodeficient xenograft model. Differentiation. 1995 Jun; 58(5):361-71.Differentiation1995-06-01T00:00:001995Human intestinal development in a severe-combined immunodeficient xenograft model.7816561Savidge TC, Smith MW, Mayel-Afshar S, Collins AJ, Freeman TCPflugers Archiv : European journal of physiologySelective regulation of epithelial gene expression in rabbit Peyer's patch tissue. Pflugers Arch. 1994 Oct; 428(3-4):391-9.Pflugers Arch1994-10-01T00:00:001994Selective regulation of epithelial gene expression in rabbit Peyer's patch tissue.8269028Brown D, Smith MW, James PS, Savidge TCEpithelial cell biologyPossible models describing enterocyte replacement in mouse Peyer's patch follicle-associated epithelial tissue. Epithelial Cell Biol. 1993 Oct; 2(4):135-42.Epithelial Cell Biol1993-10-01T00:00:001993Possible models describing enterocyte replacement in mouse Peyer's patch follicle-associated epithelial tissue.8472299Jepson MA, Simmons NL, Savidge TC, James PS, Hirst BHCell and tissue researchSelective binding and transcytosis of latex microspheres by rabbit intestinal M cells. Cell Tissue Res. 1993 Mar; 271(3):399-405.Cell Tissue Res1993-03-01T00:00:001993Selective binding and transcytosis of latex microspheres by rabbit intestinal M cells.8525916Savidge TC, Smith MWAdvances in experimental medicine and biologyEvidence that membranous (M) cell genesis is immuno-regulated. Adv Exp Med Biol. 1995; 371A:239-41.Adv Exp Med Biol1995-01-01T00:00:001995Evidence that membranous (M) cell genesis is immuno-regulated.8525917Savidge TC, Smith MW, James PSAdvances in experimental medicine and biologyA confocal microscopical analysis of Peyer's patch membranous (M) cell and lymphocyte interactions in the scid mouse. Adv Exp Med Biol. 1995; 371A:243-5.Adv Exp Med Biol1995-01-01T00:00:001995A confocal microscopical analysis of Peyer's patch membranous (M) cell and lymphocyte interactions in the scid mouse.7698683Savidge TC, Walker-Smith JA, Phillips AD, Savidge TCGutIntestinal proliferation in coeliac disease: looking into the crypt. Gut. 1995 Mar; 36(3):321-3.Gut1995-03-01T00:00:001995Intestinal proliferation in coeliac disease: looking into the crypt.8856867Savidge TCTrends in microbiologyThe life and times of an intestinal M cell. Trends Microbiol. 1996 Aug; 4(8):301-6.Trends Microbiol1996-08-01T00:00:001996The life and times of an intestinal M cell.8977336Savidge TC, Shmakov AN, Walker-Smith JA, Phillips ADGutEpithelial cell proliferation in childhood enteropathies. Gut. 1996 Aug; 39(2):185-93.Gut1996-08-01T00:00:001996Epithelial cell proliferation in childhood enteropathies.9393797Laurent F, Eckmann L, Savidge TC, Morgan G, Theodos C, Naciri M, Kagnoff MFInfection and immunityCryptosporidium parvum infection of human intestinal epithelial cells induces the polarized secretion of C-X-C chemokines. Infect Immun. 1997 Dec; 65(12):5067-73.Infect Immun1997-12-01T00:00:001997Cryptosporidium parvum infection of human intestinal epithelial cells induces the polarized secretion of C-X-C chemokines.9819367Kim JM, Eckmann L, Savidge TC, Lowe DC, Witth?ft T, Kagnoff MFThe Journal of clinical investigationApoptosis of human intestinal epithelial cells after bacterial invasion. J Clin Invest. 1998 Nov 15; 102(10):1815-23.J Clin Invest1998-11-15T00:00:001998Apoptosis of human intestinal epithelial cells after bacterial invasion.9824580Buisine MP, Devisme L, Savidge TC, Gespach C, Gosselin B, Porchet N, Aubert JPGutMucin gene expression in human embryonic and fetal intestine. Gut. 1998 Oct; 43(4):519-24.Gut1998-10-01T00:00:001998Mucin gene expression in human embryonic and fetal intestine.9427808Whyte A, Locke D, Savidge T, Licence STCellular immunologyPig lymphocytes utilise mouse MAdCAM-1 to enter fetal gut xenografts in SCID mice. Cell Immunol. 1997 Nov 25; 182(1):38-44.Cell Immunol1997-11-25T00:00:001997Pig lymphocytes utilise mouse MAdCAM-1 to enter fetal gut xenografts in SCID mice.9568712Bush TG, Savidge TC, Freeman TC, Cox HJ, Campbell EA, Mucke L, Johnson MH, Sofroniew MVCellFulminant jejuno-ileitis following ablation of enteric glia in adult transgenic mice. Cell. 1998 Apr 17; 93(2):189-201.Cell1998-04-17T00:00:001998Fulminant jejuno-ileitis following ablation of enteric glia in adult transgenic mice.Authorship 2967677Authorship 2976582Authorship 303135110941961Savidge TCJournal of pediatric gastroenterology and nutritionGastrointestinal response to food: artificial or not? J Pediatr Gastroenterol Nutr. 2000 Aug; 31(2):118-20.J Pediatr Gastroenterol Nutr2000-08-01T00:00:002000Gastrointestinal response to food: artificial or not?25865048MacEachern SJ, Patel BA, Keenan CM, Dicay M, Chapman K, McCafferty DM, Savidge TC, Beck PL, MacNaughton WK, Sharkey KAGastroenterologyInhibiting Inducible Nitric Oxide Synthase in Enteric Glia Restores Electrogenic Ion Transport in Mice With Colitis. Gastroenterology. 2015 Aug; 149(2):445-55.e3.Gastroenterology2015-04-09T00:00:002015Inhibiting Inducible Nitric Oxide Synthase in Enteric Glia Restores Electrogenic Ion Transport in Mice With Colitis.26315427Chen D, Savidge TScience (New York, N.Y.)BIOPHYSICS. Comment on "Extreme electric fields power catalysis in the active site of ketosteroid isomerase". Science. 2015 Aug 28; 349(6251):936.Science2015-08-27T00:00:002015BIOPHYSICS. Comment on "Extreme electric fields power catalysis in the active site of ketosteroid isomerase".26778967Savidge TCFrontiers in cellular neuroscienceEpigenetic Regulation of Enteric Neurotransmission by Gut Bacteria. Front Cell Neurosci. 2015; 9:503.Front Cell Neurosci2016-01-08T00:00:002016Epigenetic Regulation of Enteric Neurotransmission by Gut Bacteria.9916080Lowe DC, Savidge TC, Pickard D, Eckmann L, Kagnoff MF, Dougan G, Chatfield SNInfection and immunityCharacterization of candidate live oral Salmonella typhi vaccine strains harboring defined mutations in aroA, aroC, and htrA. Infect Immun. 1999 Feb; 67(2):700-7.Infect Immun1999-02-01T00:00:001999Characterization of candidate live oral Salmonella typhi vaccine strains harboring defined mutations in aroA, aroC, and htrA.10204503Murch SH, Fertleman CR, Rodrigues C, Morgan G, Klein NJ, Meadows N, Savidge TC, Phillips AD, Walker-Smith JAJournal of pediatric gastroenterology and nutritionAutoimmune enteropathy with distinct mucosal features in T-cell activation deficiency: the contribution of T cells to the mucosal lesion. J Pediatr Gastroenterol Nutr. 1999 Apr; 28(4):393-9.J Pediatr Gastroenterol Nutr1999-04-01T00:00:001999Autoimmune enteropathy with distinct mucosal features in T-cell activation deficiency: the contribution of T cells to the mucosal lesion.8882817Shmakov AN, Morey AL, Ferguson DJ, Fleming KA, O'Brien JA, Savidge TCDifferentiation; research in biological diversityConventional patterns of human intestinal proliferation in a severe-combined immunodeficient xenograft model. Differentiation. 1995 Dec; 59(5):321-30.Differentiation1995-12-01T00:00:001995Conventional patterns of human intestinal proliferation in a severe-combined immunodeficient xenograft model.12595589Claud EC, Savidge T, Walker WAPediatric researchModulation of human intestinal epithelial cell IL-8 secretion by human milk factors. Pediatr Res. 2003 Mar; 53(3):419-25.Pediatr Res2003-03-01T00:00:002003Modulation of human intestinal epithelial cell IL-8 secretion by human milk factors.12891543Savidge TC, Pan WH, Newman P, O'brien M, Anton PM, Pothoulakis CGastroenterologyClostridium difficile toxin B is an inflammatory enterotoxin in human intestine. Gastroenterology. 2003 Aug; 125(2):413-20.Gastroenterology2003-08-01T00:00:002003Clostridium difficile toxin B is an inflammatory enterotoxin in human intestine.15123795Mrsny RJ, Gewirtz AT, Siccardi D, Savidge T, Hurley BP, Madara JL, McCormick BAProceedings of the National Academy of Sciences of the United States of AmericaIdentification of hepoxilin A3 in inflammatory events: a required role in neutrophil migration across intestinal epithelia. Proc Natl Acad Sci U S A. 2004 May 11; 101(19):7421-6.Proc Natl Acad Sci U S A2004-05-03T00:00:002004Identification of hepoxilin A3 in inflammatory events: a required role in neutrophil migration across intestinal epithelia.74Professor10Assistant Professor21Chair14Associate Professor46Distinguished Emeritus Professor12736381Lu L, Baldeon ME, Savidge T, Pothoulakis C, Walker WAPediatric researchDevelopment of microbial-human enterocyte interaction: cholera toxin. Pediatr Res. 2003 Aug; 54(2):212-8.Pediatr Res2003-05-07T00:00:002003Development of microbial-human enterocyte interaction: cholera toxin.16423922Neunlist M, Aubert P, Bonnaud S, Van Landeghem L, Coron E, Wedel T, Naveilhan P, Ruhl A, Lardeux B, Savidge T, Paris F, Galmiche JPAmerican journal of physiology. Gastrointestinal and liver physiologyEnteric glia inhibit intestinal epithelial cell proliferation partly through a TGF-beta1-dependent pathway. Am J Physiol Gastrointest Liver Physiol. 2007 Jan; 292(1):G231-41.Am J Physiol Gastrointest Liver Physiol2006-01-19T00:00:002006Enteric glia inhibit intestinal epithelial cell proliferation partly through a TGF-beta1-dependent pathway.Authorship 323127627051863Chen D, Oezguen N, Urvil P, Ferguson C, Dann SM, Savidge TCScience advancesRegulation of protein-ligand binding affinity by hydrogen bond pairing. Sci Adv. 2016 03; 2(3):e1501240.Sci Adv2016-03-25T00:00:002016Regulation of protein-ligand binding affinity by hydrogen bond pairing.Authorship 325133527180007Spinler JK, Brown A, Ross CL, Boonma P, Conner ME, Savidge TCAnaerobeAdministration of probiotic kefir to mice with Clostridium difficile infection exacerbates disease. Anaerobe. 2016 Aug; 40:54-7.Anaerobe2016-05-11T00:00:002016Administration of probiotic kefir to mice with Clostridium difficile infection exacerbates disease.12465048Cabarrocas J, Savidge TC, Liblau RSGliaRole of enteric glial cells in inflammatory bowel disease. Glia. 2003 Jan; 41(1):81-93.Glia2003-01-01T00:00:002003Role of enteric glial cells in inflammatory bowel disease.12646731Buisine MP, Aubert JP, Walker WA, Savidge TCPediatric researchDevelopmental patterns of mucin gene expression in human fetal small intestinal xenografts maintained in severe-combined immunodeficient mice. Pediatr Res. 2003 Jun; 53(6):898-904.Pediatr Res2003-03-19T00:00:002003Developmental patterns of mucin gene expression in human fetal small intestinal xenografts maintained in severe-combined immunodeficient mice.15767259Kim H, Rhee SH, Kokkotou E, Na X, Savidge T, Moyer MP, Pothoulakis C, LaMont JTThe Journal of biological chemistryClostridium difficile toxin A regulates inducible cyclooxygenase-2 and prostaglandin E2 synthesis in colonocytes via reactive oxygen species and activation of p38 MAPK. J Biol Chem. 2005 Jun 03; 280(22):21237-45.J Biol Chem2005-03-14T00:00:002005Clostridium difficile toxin A regulates inducible cyclooxygenase-2 and prostaglandin E2 synthesis in colonocytes via reactive oxygen species and activation of p38 MAPK.1102 BATESHouston, 77030TXAuthorship 3279952Authorship 327997227180006Ross CL, Spinler JK, Savidge TCAnaerobeStructural and functional changes within the gut microbiota and susceptibility to Clostridium difficile infection. Anaerobe. 2016 Oct; 41:37-43.Anaerobe2016-05-12T00:00:002016Structural and functional changes within the gut microbiota and susceptibility to Clostridium difficile infection.27180657Spinler JK, Ross CL, Savidge TCAnaerobeProbiotics as adjunctive therapy for preventing Clostridium difficile infection - What are we waiting for? Anaerobe. 2016 Oct; 41:51-57.Anaerobe2016-05-13T00:00:002016Probiotics as adjunctive therapy for preventing Clostridium difficile infection - What are we waiting for?22069662Sun X, Savidge T, Feng HToxinsThe enterotoxicity of Clostridium difficile toxins. Toxins (Basel). 2010 07; 2(7):1848-80.Toxins (Basel)2010-07-14T00:00:002010The enterotoxicity of Clostridium difficile toxins.1853932Savidge TC, Smith MW, James PS, Aldred PThe American journal of pathologySalmonella-induced M-cell formation in germ-free mouse Peyer's patch tissue. Am J Pathol. 1991 Jul; 139(1):177-84.Am J Pathol1991-07-01T00:00:001991Salmonella-induced M-cell formation in germ-free mouse Peyer's patch tissue.22615245Wang H, Sun X, Zhang Y, Li S, Chen K, Shi L, Nie W, Kumar R, Tzipori S, Wang J, Savidge T, Feng HInfection and immunityA chimeric toxin vaccine protects against primary and recurrent Clostridium difficile infection. Infect Immun. 2012 Aug; 80(8):2678-88.Infect Immun2012-05-21T00:00:002012A chimeric toxin vaccine protects against primary and recurrent Clostridium difficile infection.16326999Savidge TC, Newman PG, Pan WH, Weng MQ, Shi HN, McCormick BA, Quaroni A, Walker WAPediatric researchLipopolysaccharide-induced human enterocyte tolerance to cytokine-mediated interleukin-8 production may occur independently of TLR-4/MD-2 signaling. Pediatr Res. 2006 Jan; 59(1):89-95.Pediatr Res2005-12-02T00:00:002005Lipopolysaccharide-induced human enterocyte tolerance to cytokine-mediated interleukin-8 production may occur independently of TLR-4/MD-2 signaling.17607301Savidge TC, Sofroniew MV, Neunlist MLaboratory investigation; a journal of technical methods and pathologyStarring roles for astroglia in barrier pathologies of gut and brain. Lab Invest. 2007 Aug; 87(8):731-6.Lab Invest2007-07-02T00:00:002007Starring roles for astroglia in barrier pathologies of gut and brain.18479256Neunlist M, Van Landeghem L, Bourreille A, Savidge TJournal of internal medicineNeuro-glial crosstalk in inflammatory bowel disease. J Intern Med. 2008 Jun; 263(6):577-83.J Intern Med2008-06-01T00:00:002008Neuro-glial crosstalk in inflammatory bowel disease.18634610Savidge TCNeuron glia biologyMIND the gap: an astroglial perspective on barrier regulation. Neuron Glia Biol. 2007 Aug; 3(3):191-7.Neuron Glia Biol2007-08-01T00:00:002007MIND the gap: an astroglial perspective on barrier regulation.18824554Kokkotou E, Espinoza DO, Torres D, Karagiannides I, Kosteletos S, Savidge T, O'Brien M, Pothoulakis CGutMelanin-concentrating hormone (MCH) modulates C difficile toxin A-mediated enteritis in mice. Gut. 2009 Jan; 58(1):34-40.Gut2008-09-29T00:00:002008Melanin-concentrating hormone (MCH) modulates C difficile toxin A-mediated enteritis in mice.Authorship 1001388Authorship 6519135Authorship 6521632Authorship 65218415Authorship 654482127398286Luna RA, Savidge TC, Williams KCCurrent developmental disorders reportsThe Brain-Gut-Microbiome Axis: What Role Does It Play in Autism Spectrum Disorder? Curr Dev Disord Rep. 2016 Mar; 3(1):75-81.Curr Dev Disord Rep2016-02-26T00:00:002016The Brain-Gut-Microbiome Axis: What Role Does It Play in Autism Spectrum Disorder?27458085Pokusaeva K, Johnson C, Luk B, Uribe G, Fu Y, Oezguen N, Matsunami RK, Lugo M, Major A, Mori-Akiyama Y, Hollister EB, Dann SM, Shi XZ, Engler DA, Savidge T, Versalovic JNeurogastroenterology and motility : the official journal of the European Gastrointestinal Motility SocietyGABA-producing Bifidobacterium dentium modulates visceral sensitivity in the intestine. Neurogastroenterol Motil. 2017 Jan; 29(1).Neurogastroenterol Motil2016-07-25T00:00:002016GABA-producing Bifidobacterium dentium modulates visceral sensitivity in the intestine.23814528Juneau C, Mendias EN, Wagal N, Loeffelholz M, Savidge T, Croisant S, Dann SThe journal for nurse practitioners : JNPCommunity-Acquired Clostridium Difficile Infection: Awareness and Clinical Implications. J Nurse Pract. 2013 Jan; 9(1):1-6.J Nurse Pract2013-01-01T00:00:002013Community-Acquired Clostridium Difficile Infection: Awareness and Clinical Implications.28060888Str?m J, Tham J, M?nsson F, Ahl J, Savidge TC, Dann SM, Resman FPloS oneThe Association between GABA-Modulators and Clostridium difficile Infection - A Matched Retrospective Case-Control Study. PLoS One. 2017; 12(1):e0169386.PLoS One2017-01-06T00:00:002017The Association between GABA-Modulators and Clostridium difficile Infection - A Matched Retrospective Case-Control Study.Authorship 702325121139062Flamant M, Aubert P, Rolli-Derkinderen M, Bourreille A, Neunlist MR, Mah? MM, Meurette G, Marteyn B, Savidge T, Galmiche JP, Sansonetti PJ, Neunlist MGutEnteric glia protect against Shigella flexneri invasion in intestinal epithelial cells: a role for S-nitrosoglutathione. Gut. 2011 Apr; 60(4):473-84.Gut2010-12-07T00:00:002010Enteric glia protect against Shigella flexneri invasion in intestinal epithelial cells: a role for S-nitrosoglutathione.28174703Savidge TCCellular and molecular gastroenterology and hepatologyGlial Orchestrated Neurodegeneration: An Important Crossroad for Neural Stem Cell Therapy to the Intestine. Cell Mol Gastroenterol Hepatol. 2016 Jan; 2(1):9-10.Cell Mol Gastroenterol Hepatol2015-11-26T00:00:002015Glial Orchestrated Neurodegeneration: An Important Crossroad for Neural Stem Cell Therapy to the Intestine.21350188Van Landeghem L, Chevalier J, Mah? MM, Wedel T, Urvil P, Derkinderen P, Savidge T, Neunlist MAmerican journal of physiology. Gastrointestinal and liver physiologyEnteric glia promote intestinal mucosal healing via activation of focal adhesion kinase and release of proEGF. Am J Physiol Gastrointest Liver Physiol. 2011 Jun; 300(6):G976-87.Am J Physiol Gastrointest Liver Physiol2011-02-24T00:00:002011Enteric glia promote intestinal mucosal healing via activation of focal adhesion kinase and release of proEGF.21807608Savidge TCThe Journal of physiologyGlia and NO nicotine: a perfect harmony for secretory control. J Physiol. 2011 Aug 01; 589(Pt 15):3685-6.J Physiol2011-08-01T00:00:002011Glia and NO nicotine: a perfect harmony for secretory control.21857653Savidge TC, Urvil P, Oezguen N, Ali K, Choudhury A, Acharya V, Pinchuk I, Torres AG, English RD, Wiktorowicz JE, Loeffelholz M, Kumar R, Shi L, Nie W, Braun W, Herman B, Hausladen A, Feng H, Stamler JS, Pothoulakis CNature medicineHost S-nitrosylation inhibits clostridial small molecule-activated glucosylating toxins. Nat Med. 2011 Aug 21; 17(9):1136-41.Nat Med2011-08-21T00:00:002011Host S-nitrosylation inhibits clostridial small molecule-activated glucosylating toxins.22416257Medina MA, Couturier J, Feske ML, Mahne AE, Turner M, Yu X, Kozinetz CA, Orozco AF, Hutchison AT, Savidge TC, Rodgers JR, Lewis DEJournal of leukocyte biologyGranzyme B- and Fas ligand-mediated cytotoxic function induced by mitogenic CD28 stimulation of human memory CD4+ T cells. J Leukoc Biol. 2012 May; 91(5):759-71.J Leukoc Biol2012-03-13T00:00:002012Granzyme B- and Fas ligand-mediated cytotoxic function induced by mitogenic CD28 stimulation of human memory CD4+ T cells.21441985Savidge TCFrontiers in neuroscienceS-nitrosothiol signals in the enteric nervous system: lessons learnt from big brother. Front Neurosci. 2011; 5:31.Front Neurosci2011-03-09T00:00:002011S-nitrosothiol signals in the enteric nervous system: lessons learnt from big brother.23484044Zhang Y, Shi L, Li S, Yang Z, Standley C, Yang Z, ZhuGe R, Savidge T, Wang X, Feng HPloS oneA segment of 97 amino acids within the translocation domain of Clostridium difficile toxin B is essential for toxicity. PLoS One. 2013; 8(3):e58634.PLoS One2013-03-06T00:00:002013A segment of 97 amino acids within the translocation domain of Clostridium difficile toxin B is essential for toxicity.Authorship 840759922356854Oezguen N, Power TD, Urvil P, Feng H, Pothoulakis C, Stamler JS, Braun W, Savidge TCGut microbesClostridial toxins: sensing a target in a hostile gut environment. Gut Microbes. 2012 Jan-Feb; 3(1):35-41.Gut Microbes2012-01-01T00:00:002012Clostridial toxins: sensing a target in a hostile gut environment.28275689Luna RA, Oezguen N, Balderas M, Venkatachalam A, Runge JK, Versalovic J, Veenstra-VanderWeele J, Anderson GM, Savidge T, Williams KCCellular and molecular gastroenterology and hepatologyDistinct Microbiome-Neuroimmune Signatures Correlate With?Functional Abdominal Pain in Children With Autism Spectrum Disorder. Cell Mol Gastroenterol Hepatol. 2017 Mar; 3(2):218-230.Cell Mol Gastroenterol Hepatol2016-12-11T00:00:002016Distinct Microbiome-Neuroimmune Signatures Correlate With?Functional Abdominal Pain in Children With Autism Spectrum Disorder.7655824Savidge TC, Shmakova AJournal of drug targetingHuman gastrointestinal drug delivery; an experimental chimeric approach. J Drug Target. 1995; 3(1):71-4.J Drug Target1995-01-01T00:00:001995Human gastrointestinal drug delivery; an experimental chimeric approach.7698694Savidge TC, Walker-Smith JA, Phillips ADGutNovel insights into human intestinal epithelial cell proliferation in health and disease using confocal microscopy. Gut. 1995 Mar; 36(3):369-74.Gut1995-03-01T00:00:001995Novel insights into human intestinal epithelial cell proliferation in health and disease using confocal microscopy.8755670Huang GT, Eckmann L, Savidge TC, Kagnoff MFThe Journal of clinical investigationInfection of human intestinal epithelial cells with invasive bacteria upregulates apical intercellular adhesion molecule-1 (ICAM)-1) expression and neutrophil adhesion. J Clin Invest. 1996 Jul 15; 98(2):572-83.J Clin Invest1996-07-15T00:00:001996Infection of human intestinal epithelial cells with invasive bacteria upregulates apical intercellular adhesion molecule-1 (ICAM)-1) expression and neutrophil adhesion.8971485Shmakov AN, Savidge TCEpithelial cell biologyCellular proliferation in the crypt epithelium of human small intestinal xenografts. Epithelial Cell Biol. 1995; 4(3):104-12.Epithelial Cell Biol1995-01-01T00:00:001995Cellular proliferation in the crypt epithelium of human small intestinal xenografts.9218506Eckmann L, Stenson WF, Savidge TC, Lowe DC, Barrett KE, Fierer J, Smith JR, Kagnoff MFThe Journal of clinical investigationRole of intestinal epithelial cells in the host secretory response to infection by invasive bacteria. Bacterial entry induces epithelial prostaglandin h synthase-2 expression and prostaglandin E2 and F2alpha production. J Clin Invest. 1997 Jul 15; 100(2):296-309.J Clin Invest1997-07-15T00:00:001997Role of intestinal epithelial cells in the host secretory response to infection by invasive bacteria. Bacterial entry induces epithelial prostaglandin h synthase-2 expression and prostaglandin E2 and F2alpha production.9529115Laurent F, Kagnoff MF, Savidge TC, Naciri M, Eckmann LInfection and immunityHuman intestinal epithelial cells respond to Cryptosporidium parvum infection with increased prostaglandin H synthase 2 expression and prostaglandin E2 and F2alpha production. Infect Immun. 1998 Apr; 66(4):1787-90.Infect Immun1998-04-01T00:00:001998Human intestinal epithelial cells respond to Cryptosporidium parvum infection with increased prostaglandin H synthase 2 expression and prostaglandin E2 and F2alpha production.Authorship 872627628592627Yu H, Chen K, Sun Y, Carter M, Garey KW, Savidge TC, Devaraj S, Tessier ME, von Rosenvinge EC, Kelly CP, Pasetti MF, Feng HClinical and vaccine immunology : CVICytokines Are Markers of the Clostridium difficile-Induced Inflammatory Response and Predict Disease Severity. Clin Vaccine Immunol. 2017 Aug; 24(8).Clin Vaccine Immunol2017-08-04T00:00:002017Cytokines Are Markers of the Clostridium difficile-Induced Inflammatory Response and Predict Disease Severity.10493151Montagne L, Toullec R, Savidge T, Lall?s JPReproduction, nutrition, developmentMorphology and enzyme activities of the small intestine are modulated by dietary protein source in the preruminant calf. Reprod Nutr Dev. 1999 Jul-Aug; 39(4):455-66.Reprod Nutr Dev1999-07-01T00:00:001999Morphology and enzyme activities of the small intestine are modulated by dietary protein source in the preruminant calf.Authorship 8729691128457228Labus JS, Hollister EB, Jacobs J, Kirbach K, Oezguen N, Gupta A, Acosta J, Luna RA, Aagaard K, Versalovic J, Savidge T, Hsiao E, Tillisch K, Mayer EAMicrobiomeDifferences in gut microbial composition correlate with regional brain volumes in irritable bowel syndrome. Microbiome. 2017 05 01; 5(1):49.Microbiome2017-05-01T00:00:002017Differences in gut microbial composition correlate with regional brain volumes in irritable bowel syndrome.1489550Porta C, James PS, Phillips AD, Savidge TC, Smith MW, Cremaschi DExperimental physiologyConfocal analysis of fluorescent bead uptake by mouse Peyer's patch follicle-associated M cells. Exp Physiol. 1992 Nov; 77(6):929-32.Exp Physiol1992-11-01T00:00:001992Confocal analysis of fluorescent bead uptake by mouse Peyer's patch follicle-associated M cells.15123821Claud EC, Lu L, Anton PM, Savidge T, Walker WA, Cherayil BJProceedings of the National Academy of Sciences of the United States of AmericaDevelopmentally regulated IkappaB expression in intestinal epithelium and susceptibility to flagellin-induced inflammation. Proc Natl Acad Sci U S A. 2004 May 11; 101(19):7404-8.Proc Natl Acad Sci U S A2004-04-27T00:00:002004Developmentally regulated IkappaB expression in intestinal epithelium and susceptibility to flagellin-induced inflammation.17408650Savidge TC, Newman P, Pothoulakis C, Ruhl A, Neunlist M, Bourreille A, Hurst R, Sofroniew MVGastroenterologyEnteric glia regulate intestinal barrier function and inflammation via release of S-nitrosoglutathione. Gastroenterology. 2007 Apr; 132(4):1344-58.Gastroenterology2007-02-01T00:00:002007Enteric glia regulate intestinal barrier function and inflammation via release of S-nitrosoglutathione.17412781Moss AC, Anton P, Savidge T, Newman P, Cheifetz AS, Gay J, Paraschos S, Winter MW, Moyer MP, Karalis K, Kokkotou E, Pothoulakis CGutUrocortin II mediates pro-inflammatory effects in human colonocytes via corticotropin-releasing hormone receptor 2alpha. Gut. 2007 Sep; 56(9):1210-7.Gut2007-04-05T00:00:002007Urocortin II mediates pro-inflammatory effects in human colonocytes via corticotropin-releasing hormone receptor 2alpha.17919497Hoogerwerf WA, Hellmich HL, Corn?lissen G, Halberg F, Shahinian VB, Bostwick J, Savidge TC, Cassone VMGastroenterologyClock gene expression in the murine gastrointestinal tract: endogenous rhythmicity and effects of a feeding regimen. Gastroenterology. 2007 Oct; 133(4):1250-60.Gastroenterology2007-07-12T00:00:002007Clock gene expression in the murine gastrointestinal tract: endogenous rhythmicity and effects of a feeding regimen.2106904Savidge TC, Smith MW, Kilshaw PJExperimental physiologyPossible lymphocyte effects on lactase expression by mouse jejunal enterocytes. Exp Physiol. 1990 Jan; 75(1):111-3.Exp Physiol1990-01-01T00:00:001990Possible lymphocyte effects on lactase expression by mouse jejunal enterocytes.20732324Chaniotou Z, Giannogonas P, Theoharis S, Teli T, Gay J, Savidge T, Koutmani Y, Brugni J, Kokkotou E, Pothoulakis C, Karalis KPGastroenterologyCorticotropin-releasing factor regulates TLR4 expression in the colon and protects mice from colitis. Gastroenterology. 2010 Dec; 139(6):2083-92.Gastroenterology2010-08-20T00:00:002010Corticotropin-releasing factor regulates TLR4 expression in the colon and protects mice from colitis.21615140Wiktorowicz JE, Stafford S, Rea H, Urvil P, Soman K, Kurosky A, Perez-Polo JR, Savidge TCBiochemistryQuantification of cysteinyl S-nitrosylation by fluorescence in unbiased proteomic studies. Biochemistry. 2011 Jun 28; 50(25):5601-14.Biochemistry2011-06-07T00:00:002011Quantification of cysteinyl S-nitrosylation by fluorescence in unbiased proteomic studies.Authorship 1048593Authorship 88273713Authorship 885662328760934Spinler JK, Auchtung J, Brown A, Boonma P, Oezguen N, Ross CL, Luna RA, Runge J, Versalovic J, Peniche A, Dann SM, Britton RA, Haag A, Savidge TCInfection and immunityNext-Generation Probiotics Targeting Clostridium difficile through Precursor-Directed Antimicrobial Biosynthesis. Infect Immun. 2017 10; 85(10).Infect Immun2017-09-20T00:00:002017Next-Generation Probiotics Targeting Clostridium difficile through Precursor-Directed Antimicrobial Biosynthesis.29665102Bajaj JS, Kakiyama G, Savidge T, Takei H, Kassam ZA, Fagan A, Gavis EA, Pandak WM, Nittono H, Hylemon PB, Boonma P, Haag A, Heuman DM, Fuchs M, John B, Sikaroodi M, Gillevet PMHepatology (Baltimore, Md.)Antibiotic-Associated Disruption of Microbiota Composition and Function in Cirrhosis Is Restored by Fecal Transplant. Hepatology. 2018 10; 68(4):1549-1558.Hepatology2018-09-20T00:00:002018Antibiotic-Associated Disruption of Microbiota Composition and Function in Cirrhosis Is Restored by Fecal Transplant.true1ProfessorProfessortrue1ProfessorProfessortrue1ProfessorProfessortrue1Assistant ProfessorAssistant ProfessorD007413Anatomy35310810.626795Intestinal MucosaAuthorship 10643D017615Anatomy16360.966424Enteric Nervous SystemD003015Disorders872520.745278Clostridium InfectionsAuthorship 9308826Authorship 9323015Authorship 9330377Authorship 9365106Authorship 938423129928672Zhong XS, Winston JH, Luo X, Kline KT, Nayeem SZ, Cong Y, Savidge TC, Dashwood RH, Powell DW, Li QCellular and molecular gastroenterology and hepatologyNeonatal Colonic Inflammation Epigenetically Aggravates Epithelial Inflammatory Responses to Injury in Adult Life. Cell Mol Gastroenterol Hepatol. 2018; 6(1):65-78.Cell Mol Gastroenterol Hepatol2018-03-09T00:00:002018Neonatal Colonic Inflammation Epigenetically Aggravates Epithelial Inflammatory Responses to Injury in Adult Life.30177854Hegde S, Lin YM, Golovko G, Khanipov K, Cong Y, Savidge T, Fofanov Y, Shi XZScientific reportsMicrobiota dysbiosis and its pathophysiological significance in bowel obstruction. Sci Rep. 2018 09 03; 8(1):13044.Sci Rep2018-09-03T00:00:002018Microbiota dysbiosis and its pathophysiological significance in bowel obstruction.30221291Chen D, Li Y, Zhao M, Tan W, Li X, Savidge T, Guo W, Fan XPhysical chemistry chemical physics : PCCPEffective lead optimization targeting the displacement of bridging receptor-ligand water molecules. Phys Chem Chem Phys. 2018 Oct 07; 20(37):24399-24407.Phys Chem Chem Phys2018-09-17T00:00:002018Effective lead optimization targeting the displacement of bridging receptor-ligand water molecules.30516774Chen D, Li Y, Guo W, Li Y, Savidge T, Li X, Fan XPhysical chemistry chemical physics : PCCPThe shielding effect of metal complexes on the binding affinities of ligands to metalloproteins. Phys Chem Chem Phys. 2018 Dec 19; 21(1):205-216.Phys Chem Chem Phys2018-12-19T00:00:002018The shielding effect of metal complexes on the binding affinities of ligands to metalloproteins.30658109Savidge T, Sorg JACell chemical biologyRole of Bile in Infectious Disease: the Gall of 7a-Dehydroxylating Gut Bacteria. Cell Chem Biol. 2019 01 17; 26(1):1-3.Cell Chem Biol2019-01-17T00:00:002019Role of Bile in Infectious Disease: the Gall of 7a-Dehydroxylating Gut Bacteria.2012-05-31NIHSAVIDGE, TOR2009-06-01S-nitrosoglutathione regulation of intestinal barrier function in Crohn's diseaseR21DK0780322018-05-31NIHSAVIDGE, TOR2012-06-01Allosteric therapy of the Clostridium difficile toxinsR01AI1009142021-07-31NIHSAVIDGE, TOR2016-08-20Decoding Antibiotic-induced Susceptibility to Clostridium difficile InfectionU01AI1242902016-08-31NIHSAVIDGE, TOR2014-09-15Metabolome-Based Biomarkers and Neutraceuticals in Clostridium Difficile InfectionR21DK096323Principal InvestigatorPrincipal InvestigatorPrincipal InvestigatorPrincipal InvestigatorDepartment of PediatricsDepartment of Molecular Virology & MicrobiologyDepartment of Pathology & ImmunologyMolecular Virology & MicrobiologyPathologyPediatrics-AdministrationPediatrics-GastroenterologyPediatrics-NutritionBaylor College of MedicineUniversity of Houston College of PharmacyRICHARDKELLERMAYERRICHARD KELLERMAYER29.70508570000000-95.401808700000001082KELLERMAYER, RICHARDProfessorYUXINFANYUXIN FAN0.000000000000000.000000000000001225FAN, YUXINAssociate ProfessorROBERTSHULMANROBERT SHULMAN0.000000000000000.000000000000002845SHULMAN, ROBERTProfessorJOSEPHPETROSINOJOSEPH PETROSINO-33.9553329000000018.461081000000002154PETROSINO, JOSEPHProfessorNUMANOEZGUENNUMAN OEZGUEN0.000000000000000.000000000000004686OEZGUEN, NUMANAssistant ProfessorRUTHLUNARUTH LUNA0.000000000000000.000000000000003631LUNA, RUTHAssociate ProfessorANNEWITSONANNE WITSON0.000000000000000.00000000000000367WITSON, ANNEAssistant ProfessorADEKUNLEADESINAADEKUNLE ADESINA0.000000000000000.00000000000000446ADESINA, ADEKUNLEDistinguished Emeritus ProfessorKEVINGAREYKEVIN W. GAREY29.70508570000000-95.401808700000004636GAREY, KEVINProfessor. Chair, Department of Pharmacy Practice and Translational Research.Authorship 9426281730793006Endres BT, Begum K, Sun H, Walk ST, Memariani A, Lancaster C, Gonzales-Luna AJ, Dotson KM, Bass?res E, Offiong C, Tupy S, Kuper K, Septimus E, Arafat R, Alam MJ, Zhao Z, Hurdle JG, Savidge TC, Garey KWOpen forum infectious diseasesEpidemic Clostridioides difficile Ribotype 027 Lineages: Comparisons of Texas Versus Worldwide Strains. Open Forum Infect Dis. 2019 Feb; 6(2):ofz013.Open Forum Infect Dis2019-02-09T00:00:002019Epidemic Clostridioides difficile Ribotype 027 Lineages: Comparisons of Texas Versus Worldwide Strains.MICHAELITTMANNMICHAEL ITTMANN0.000000000000000.000000000000002694ITTMANN, MICHAELProfessorJAMESVERSALOVICJAMES VERSALOVIC0.000000000000000.000000000000003197VERSALOVIC, JAMESProfessorDANIELROSENDANIEL ROSEN0.000000000000000.000000000000003871ROSEN, DANIELProfessor4.896590.0051415666research areas2.667690.031845741coauthor of308.40113.052360similar to11147selected publicationsAuthorship 943507430099125Peniche AG, Spinler JK, Boonma P, Savidge TC, Dann SMAnaerobeAging impairs protective host defenses against Clostridioides (Clostridium) difficile infection in mice by suppressing neutrophil and IL-22 mediated immunity. Anaerobe. 2018 Dec; 54:83-91.Anaerobe2018-08-09T00:00:002018Aging impairs protective host defenses against Clostridioides (Clostridium) difficile infection in mice by suppressing neutrophil and IL-22 mediated immunity.Authorship 1098051Authorship 94550316Authorship 945771831005411Hollister EB, Oezguen N, Chumpitazi BP, Luna RA, Weidler EM, Rubio-Gonzales M, Dahdouli M, Cope JL, Mistretta TA, Raza S, Metcalf GA, Muzny DM, Gibbs RA, Petrosino JF, Heitkemper M, Savidge TC, Shulman RJ, Versalovic JThe Journal of molecular diagnostics : JMDLeveraging Human Microbiome Features to Diagnose and Stratify Children with Irritable Bowel Syndrome. J Mol Diagn. 2019 05; 21(3):449-461.J Mol Diagn2019-04-17T00:00:002019Leveraging Human Microbiome Features to Diagnose and Stratify Children with Irritable Bowel Syndrome.31022477Hung LY, Boonma P, Unterweger P, Parathan P, Haag A, Luna RA, Bornstein JC, Savidge TC, Foong JPPCellular and molecular gastroenterology and hepatologyNeonatal Antibiotics Disrupt?Motility and Enteric Neural Circuits in Mouse Colon. Cell Mol Gastroenterol Hepatol. 2019; 8(2):298-300.e6.Cell Mol Gastroenterol Hepatol2019-04-22T00:00:002019Neonatal Antibiotics Disrupt?Motility and Enteric Neural Circuits in Mouse Colon.D0000691962759050.521005Gastrointestinal MicrobiomeD064307Living Beings2235510.61432MicrobiotaAuthorship 129115223982235Peniche AG, Savidge TC, Dann SMCurrent opinion in infectious diseasesRecent insights into Clostridium difficile pathogenesis. Curr Opin Infect Dis. 2013 Oct; 26(5):447-53.Curr Opin Infect Dis2013-10-01T00:00:002013Recent insights into Clostridium difficile pathogenesis.Authorship 94770511Authorship 948436631119867Hosie S, Ellis M, Swaminathan M, Ramalhosa F, Seger GO, Balasuriya GK, Gillberg C, R?stam M, Churilov L, McKeown SJ, Yalcinkaya N, Urvil P, Savidge T, Bell CA, Bodin O, Wood J, Franks AE, Bornstein JC, Hill-Yardin ELAutism research : official journal of the International Society for Autism ResearchGastrointestinal dysfunction in patients and mice expressing the autism-associated R451C mutation in neuroligin-3. Autism Res. 2019 07; 12(7):1043-1056.Autism Res2019-05-22T00:00:002019Gastrointestinal dysfunction in patients and mice expressing the autism-associated R451C mutation in neuroligin-3.31172918Oezguen N, Yalcinkaya N, K?c?kali CI, Dahdouli M, Hollister EB, Luna RA, T?rkoglu R, K?rt?nc? M, Eraksoy M, Savidge TC, T?z?n EClinical and experimental rheumatologyMicrobiota stratification identifies disease-specific alterations in neuro-Beh?et's disease and multiple sclerosis. Clin Exp Rheumatol. 2019 Nov-Dec; 37 Suppl 121(6):58-66.Clin Exp Rheumatol2019-05-30T00:00:002019Microbiota stratification identifies disease-specific alterations in neuro-Beh?et's disease and multiple sclerosis.Authorship 9513111231253983Kociolek LK, Espinosa RO, Gerding DN, Hauser AR, Ozer EA, Budz M, Balaji A, Chen X, Tanz RR, Yalcinkaya N, Conner ME, Savidge T, Kelly CPClinical infectious diseases : an official publication of the Infectious Diseases Society of AmericaNatural Clostridioides difficile Toxin Immunization in Colonized Infants. Clin Infect Dis. 2020 05 06; 70(10):2095-2102.Clin Infect Dis2020-05-06T00:00:002020Natural Clostridioides difficile Toxin Immunization in Colonized Infants.Authorship 952900531356842Horvath TD, Ak S, Haidacher SJ, Hoch KM, Savidge TC, Haag AMJournal of microbiological methodsSterilization performance comparison between an autosampler-ready microporous filter vial and a syringe-based filter. J Microbiol Methods. 2019 09; 164:105669.J Microbiol Methods2019-07-26T00:00:002019Sterilization performance comparison between an autosampler-ready microporous filter vial and a syringe-based filter.Authorship 9548341231478755Arnold LE, Luna RA, Williams K, Chan J, Parker RA, Wu Q, Hollway JA, Jeffs A, Lu F, Coury DL, Hayes C, Savidge TJournal of child and adolescent psychopharmacologyProbiotics for Gastrointestinal Symptoms and Quality of Life in Autism: A Placebo-Controlled Pilot Trial. J Child Adolesc Psychopharmacol. 2019 11; 29(9):659-669.J Child Adolesc Psychopharmacol2019-08-30T00:00:002019Probiotics for Gastrointestinal Symptoms and Quality of Life in Autism: A Placebo-Controlled Pilot Trial.80Professor. Chair, Department of Pharmacy Practice and Translational Research.true1Professor. Chair, Department of Pharmacy Practice and Translational Research.Professor. Chair, Department of Pharmacy Practice and Translational Research.Pharmacy Practice and Translational ResearchAuthorship 957040331603615Sallam HS, Urvil P, Savidge TC, Chen JDZNeurogastroenterology and motility : the official journal of the European Gastrointestinal Motility SocietyGhrelin abates bacterial translocation following burn injury by improving gastric emptying. Neurogastroenterol Motil. 2020 02; 32(2):e13742.Neurogastroenterol Motil2019-10-11T00:00:002019Ghrelin abates bacterial translocation following burn injury by improving gastric emptying.Authorship 95731711Authorship 957404631617299Spinner JA, Bocchini CE, Luna RA, Thapa S, Balderas MA, Denfield SW, Dreyer WJ, Nagy-Szakal D, Ihekweazu FD, Versalovic J, Savidge T, Kellermayer RPediatric transplantationFecal microbiota transplantation in a toddler after heart transplant was a safe and effective treatment for recurrent Clostridiodes difficile infection: A case report. Pediatr Transplant. 2020 02; 24(1):e13598.Pediatr Transplant2019-10-16T00:00:002019Fecal microbiota transplantation in a toddler after heart transplant was a safe and effective treatment for recurrent Clostridiodes difficile infection: A case report.31624167Spinler JK, Gonzales-Luna AJ, Raza S, Runge JK, Luna RA, Savidge TC, Garey KWMicrobiology resource announcementsComplete Genome Sequence of Clostridioides difficile Ribotype 255 Strain Mta-79, Assembled Using Oxford Nanopore and Illumina Sequencing. Microbiol Resour Announc. 2019 Oct 17; 8(42).Microbiol Resour Announc2019-10-17T00:00:002019Complete Genome Sequence of Clostridioides difficile Ribotype 255 Strain Mta-79, Assembled Using Oxford Nanopore and Illumina Sequencing.true1ProfessorProfessorAuthorship 975043731889022Kline KT, Lian H, Zhong XS, Luo X, Winston JH, Cong Y, Savidge TC, Dashwood RH, Powell DW, Li QJournal of immunology (Baltimore, Md. : 1950)Neonatal Injury Increases Gut Permeability by Epigenetically Suppressing E-Cadherin in Adulthood. J Immunol. 2020 02 15; 204(4):980-989.J Immunol2019-12-30T00:00:002019Neonatal Injury Increases Gut Permeability by Epigenetically Suppressing E-Cadherin in Adulthood.71Postdoc Fellows and AssociatesPostDocAuthorship 979024732156806Andersson JA, Peniche AG, Galindo CL, Boonma P, Sha J, Luna RA, Savidge TC, Chopra AK, Dann SMmBioNew Host-Directed Therapeutics for the Treatment of Clostridioides difficile Infection. mBio. 2020 03 10; 11(2).mBio2020-03-10T00:00:002020New Host-Directed Therapeutics for the Treatment of Clostridioides difficile Infection.Authorship 986776232272094Wu Q, Savidge TCTranslational research : the journal of laboratory and clinical medicineSystems approaches for the clinical diagnosis of Clostridioides difficile infection. Transl Res. 2020 06; 220:57-67.Transl Res2020-03-16T00:00:002020Systems approaches for the clinical diagnosis of Clostridioides difficile infection.Authorship 989234932390463Hung LY, Parathan P, Boonma P, Wu Q, Wang Y, Haag A, Luna RA, Bornstein JC, Savidge TC, Foong JPPAmerican journal of physiology. Gastrointestinal and liver physiologyAntibiotic exposure postweaning disrupts the neurochemistry and function of enteric neurons mediating colonic motor activity. Am J Physiol Gastrointest Liver Physiol. 2020 06 01; 318(6):G1042-G1053.Am J Physiol Gastrointest Liver Physiol2020-05-11T00:00:002020Antibiotic exposure postweaning disrupts the neurochemistry and function of enteric neurons mediating colonic motor activity.Authorship 9919914Authorship 992475432544947Aitken SL, Sahasrabhojane PV, Kontoyiannis DP, Savidge TC, Arias CA, Ajami NJ, Shelburne SA, Galloway-Pe?a JRClinical infectious diseases : an official publication of the Infectious Diseases Society of AmericaAlterations of the Oral Microbiome and Cumulative Carbapenem Exposure Are Associated With Stenotrophomonas maltophilia Infection in Patients With Acute Myeloid Leukemia Receiving Chemotherapy. Clin Infect Dis. 2021 05 04; 72(9):1507-1513.Clin Infect Dis2021-05-04T00:00:002021Alterations of the Oral Microbiome and Cumulative Carbapenem Exposure Are Associated With Stenotrophomonas maltophilia Infection in Patients With Acute Myeloid Leukemia Receiving Chemotherapy.32569084Hegde S, Lin YM, Fu Y, Savidge T, Shi XZPainPrecision Lactobacillus reuteri therapy attenuates luminal distension-associated visceral hypersensitivity by inducing peripheral opioid receptors in the colon. Pain. 2020 12; 161(12):2737-2749.Pain2020-12-01T00:00:002020Precision Lactobacillus reuteri therapy attenuates luminal distension-associated visceral hypersensitivity by inducing peripheral opioid receptors in the colon.Authorship 11691332025-07-31NIHARIAS, CESAR AUGUSTO ;SAVIDGE, TOR ;SHELBURNE, SAMUEL A2020-08-01Dynamics of Colonization and Infection by Multidrug-resistant Pathogens in Immunocompromised and Critically Ill Patients (DYNAMITE)P01AI152999Co-Principal Investigatortrue1Postdoc Fellows and AssociatesPostdoc Fellows and AssociatesSik YuSoSik Yu So16238So, Sik YuPostdoc Fellows and AssociatesAuthorship 999197432902314Foong JPP, Hung LY, Poon S, Savidge TC, Bornstein JCAmerican journal of physiology. Gastrointestinal and liver physiologyEarly life interaction between the microbiota and the enteric nervous system. Am J Physiol Gastrointest Liver Physiol. 2020 11 01; 319(5):G541-G548.Am J Physiol Gastrointest Liver Physiol2020-09-09T00:00:002020Early life interaction between the microbiota and the enteric nervous system.http://www.bcm.edu/cnrc/kidsabdominalpainCenter for Pediatric Abdominal Pain ResearchAuthorship 1002915133065091Savidge TCellular and molecular gastroenterology and hepatologyPredicting Inflammatory Bowel Disease Symptoms Onset: Nitrous Take on Gut Bacteria Is No Laughing Matter. Cell Mol Gastroenterol Hepatol. 2021; 11(2):661-662.Cell Mol Gastroenterol Hepatol2020-10-14T00:00:002020Predicting Inflammatory Bowel Disease Symptoms Onset: Nitrous Take on Gut Bacteria Is No Laughing Matter.Authorship 1003209733082337Norsigian CJ, Danhof HA, Brand CK, Oezguen N, Midani FS, Palsson BO, Savidge TC, Britton RA, Spinler JK, Monk JMNPJ systems biology and applicationsSystems biology analysis of the Clostridioides difficile core-genome contextualizes microenvironmental evolutionary pressures leading to genotypic and phenotypic divergence. NPJ Syst Biol Appl. 2020 10 20; 6(1):31.NPJ Syst Biol Appl2020-10-20T00:00:002020Systems biology analysis of the Clostridioides difficile core-genome contextualizes microenvironmental evolutionary pressures leading to genotypic and phenotypic divergence.Authorship 10055401633227279Engevik MA, Danhof HA, Auchtung J, Endres BT, Ruan W, Bass?res E, Engevik AC, Wu Q, Nicholson M, Luna RA, Garey KW, Crawford SE, Estes MK, Lux R, Yacyshyn MB, Yacyshyn B, Savidge T, Britton RA, Versalovic JGastroenterologyFusobacteriumnucleatum Adheres to Clostridioides difficile via the RadD Adhesin to Enhance Biofilm Formation in Intestinal Mucus. Gastroenterology. 2021 03; 160(4):1301-1314.e8.Gastroenterology2020-11-21T00:00:002020Fusobacteriumnucleatum Adheres to Clostridioides difficile via the RadD Adhesin to Enhance Biofilm Formation in Intestinal Mucus.Authorship 1008400833412896Kamp KJ, Plantinga AM, Cain KC, Burr RL, Barney P, Jarrett M, Luna RA, Savidge T, Shulman R, Heitkemper MMBiological research for nursingA Comprehensive Self-Management Program With Diet Education Does Not Alter Microbiome Characteristics in Women With Irritable Bowel Syndrome. Biol Res Nurs. 2021 07; 23(3):471-480.Biol Res Nurs2021-01-08T00:00:002021A Comprehensive Self-Management Program With Diet Education Does Not Alter Microbiome Characteristics in Women With Irritable Bowel Syndrome.Authorship 120801Authorship 10194851134044101Gonzales-Luna AJ, Spinler JK, Oezguen N, Khan MAW, Danhof HA, Endres BT, Alam MJ, Begum K, Lancaster C, Costa GP, Savidge TC, Hurdle JG, Britton R, Garey KWAnaerobeSystems biology evaluation of refractory Clostridioides difficile infection including multiple failures of fecal microbiota transplantation. Anaerobe. 2021 Aug; 70:102387.Anaerobe2021-05-24T00:00:002021Systems biology evaluation of refractory Clostridioides difficile infection including multiple failures of fecal microbiota transplantation.Authorship 1218591Authorship 1020562234093447So SY, Savidge TCFrontiers in endocrinologySex-Bias in Irritable Bowel Syndrome: Linking Steroids to the Gut-Brain Axis. Front Endocrinol (Lausanne). 2021; 12:684096.Front Endocrinol (Lausanne)2021-05-19T00:00:002021Sex-Bias in Irritable Bowel Syndrome: Linking Steroids to the Gut-Brain Axis.Authorship 10240364Authorship 1024282434180789Miles-Jay A, Young VB, Pamer EG, Savidge TC, Kamboj M, Garey KW, Snitkin ESMicrobial genomicsA multisite genomic epidemiology study of Clostridioides difficile infections in the USA supports differential roles of healthcare versus community spread for two common strains. Microb Genom. 2021 06; 7(6).Microb Genom2021-06-01T00:00:002021A multisite genomic epidemiology study of Clostridioides difficile infections in the USA supports differential roles of healthcare versus community spread for two common strains.34200108Kvakova M, Bertkova I, Stofilova J, Savidge TCFoods (Basel, Switzerland)Co-Encapsulated Synbiotics and Immobilized Probiotics in Human Health and Gut Microbiota Modulation. Foods. 2021 Jun 04; 10(6).Foods2021-06-04T00:00:002021Co-Encapsulated Synbiotics and Immobilized Probiotics in Human Health and Gut Microbiota Modulation.Authorship 1025802934288725Blutt SE, Crawford SE, Bomidi C, Zeng XL, Broughman JR, Robertson M, Coarfa C, Tessier MEM, Savidge T, Hollinger FB, Curley SA, Donowitz M, Estes MKAmerican journal of physiology. Gastrointestinal and liver physiologyUse of human tissue stem cell-derived organoid cultures to model enterohepatic circulation. Am J Physiol Gastrointest Liver Physiol. 2021 09 01; 321(3):G270-G279.Am J Physiol Gastrointest Liver Physiol2021-07-21T00:00:002021Use of human tissue stem cell-derived organoid cultures to model enterohepatic circulation.2025-07-31NIHMARGOLIS, KARA GROSS ;SAVIDGE, TOR ;TAKSER, LARISSA ;TALATI, ARDESHEER2021-08-15A Prospective Study Examining the Role of Gestational SSRI Exposure in the Development of Functional Gastrointestinal DisordersR01DK130517Co-Principal InvestigatorAuthorship 1031469534643089So SY, Wu Q, Leung KS, Kundi ZM, Savidge TC, El-Nezami HAmerican journal of physiology. Gastrointestinal and liver physiologyYeast ?-glucan reduces obesity-associated Bilophila abundance and modulates bile acid metabolism in healthy and high-fat diet mouse models. Am J Physiol Gastrointest Liver Physiol. 2021 12 01; 321(6):G639-G655.Am J Physiol Gastrointest Liver Physiol2021-10-13T00:00:002021Yeast ?-glucan reduces obesity-associated Bilophila abundance and modulates bile acid metabolism in healthy and high-fat diet mouse models.Authorship 1031747834665847Aguirre AM, Yalcinkaya N, Wu Q, Swennes A, Tessier ME, Roberts P, Miyajima F, Savidge T, Sorg JAPLoS pathogensBile acid-independent protection against Clostridioides difficile infection. PLoS Pathog. 2021 10; 17(10):e1010015.PLoS Pathog2021-10-19T00:00:002021Bile acid-independent protection against Clostridioides difficile infection.Authorship 103353014Authorship 10336052Authorship 1034335334791392Kociolek LK, Zackular JP, Savidge TJournal of the Pediatric Infectious Diseases SocietyTranslational Aspects of the Immunology of Clostridioides difficile Infection: Implications for Pediatric Populations. J Pediatric Infect Dis Soc. 2021 Nov 17; 10(Supplement_3):S8-S15.J Pediatric Infect Dis Soc2021-11-17T00:00:002021Translational Aspects of the Immunology of Clostridioides difficile Infection: Implications for Pediatric Populations.34724447Kellermayer R, Wu Q, Nagy-Szakal D, Queliza K, Ihekweazu FD, Bocchini CE, Magee AR, Oezguen N, Spinler JK, Hollister EB, Shulman RJ, Versalovic J, Luna RA, Savidge TCJournal of pediatric gastroenterology and nutritionFecal Microbiota Transplantation Commonly Failed in Children With Co-Morbidities. J Pediatr Gastroenterol Nutr. 2022 02 01; 74(2):227-235.J Pediatr Gastroenterol Nutr2022-02-01T00:00:002022Fecal Microbiota Transplantation Commonly Failed in Children With Co-Morbidities.34730020So SY, Savidge TCAmerican journal of physiology. Gastrointestinal and liver physiologyGut feelings: the microbiota-gut-brain axis on steroids. Am J Physiol Gastrointest Liver Physiol. 2022 01 01; 322(1):G1-G20.Am J Physiol Gastrointest Liver Physiol2021-11-03T00:00:002021Gut feelings: the microbiota-gut-brain axis on steroids.true1ProfessorProfessor2ProfessorProfessorAuthorship 1035355229774575Bajaj JS, Savidge T, Kassam ZA, Hylemon PB, Gillevet PMHepatology (Baltimore, Md.)Reply. Hepatology. 2018 09; 68(3):1206.Hepatology2018-09-01T00:00:002018Reply.Authorship 1037136635013352Dimet-Wiley A, Wu Q, Wiley JT, Eswar A, Neelakantan H, Savidge T, Watowich SScientific reportsReduced calorie diet combined with NNMT inhibition establishes a distinct microbiome in DIO mice. Sci Rep. 2022 01 10; 12(1):484.Sci Rep2022-01-10T00:00:002022Reduced calorie diet combined with NNMT inhibition establishes a distinct microbiome in DIO mice.true1Associate ProfessorAssociate ProfessorAuthorship 10381342Authorship 103843012Authorship 10417831935295488Boonma P, Shapiro JM, Hollister EB, Badu S, Wu Q, Weidler EM, Abraham BP, Devaraj S, Luna RA, Versalovic J, Heitkemper MM, Savidge TC, Shulman RJFrontiers in pain research (Lausanne, Switzerland)Probiotic VSL#3 Treatment Reduces Colonic Permeability and Abdominal Pain Symptoms in Patients With Irritable Bowel Syndrome. Front Pain Res (Lausanne). 2021; 2:691689.Front Pain Res (Lausanne)2021-09-22T00:00:002021Probiotic VSL#3 Treatment Reduces Colonic Permeability and Abdominal Pain Symptoms in Patients With Irritable Bowel Syndrome.35359802Xavier JB, Monk JM, Poudel S, Norsigian CJ, Sastry AV, Liao C, Bento J, Suchard MA, Arrieta-Ortiz ML, Peterson EJR, Baliga NS, Stoeger T, Ruffin F, Richardson RAK, Gao CA, Horvath TD, Haag AM, Wu Q, Savidge T, Yeaman MRiScienceMathematical models to study the biology of pathogens and the infectious diseases they cause. iScience. 2022 Apr 15; 25(4):104079.iScience2022-03-15T00:00:002022Mathematical models to study the biology of pathogens and the infectious diseases they cause.35271353Fobofou SA, Savidge TAmerican journal of physiology. Gastrointestinal and liver physiologyMicrobial metabolites: cause or consequence in gastrointestinal disease? Am J Physiol Gastrointest Liver Physiol. 2022 06 01; 322(6):G535-G552.Am J Physiol Gastrointest Liver Physiol2022-03-10T00:00:002022Microbial metabolites: cause or consequence in gastrointestinal disease?Authorship 1044596635476524Norsigian CJ, Danhof HA, Brand CK, Midani FS, Broddrick JT, Savidge TC, Britton RA, Palsson BO, Spinler JK, Monk JMProceedings of the National Academy of Sciences of the United States of AmericaSystems biology approach to functionally assess the Clostridioides difficile pangenome reveals genetic diversity with discriminatory power. Proc Natl Acad Sci U S A. 2022 05 03; 119(18):e2119396119.Proc Natl Acad Sci U S A2022-04-27T00:00:002022Systems biology approach to functionally assess the Clostridioides difficile pangenome reveals genetic diversity with discriminatory power.Authorship 1048720535726077Zuniga-Kennedy M, Davoren M, Shuffrey LC, Luna RA, Savidge T, Prasad V, Anderson GM, Veenstra-VanderWeele J, Williams KCJournal of autism and developmental disordersIntestinal Predictors of Whole Blood Serotonin Levels in Children With or Without Autism. J Autism Dev Disord. 2022 Sep; 52(9):3780-3789.J Autism Dev Disord2022-06-21T00:00:002022Intestinal Predictors of Whole Blood Serotonin Levels in Children With or Without Autism.Authorship 1049312835773532Curry KD, Wang Q, Nute MG, Tyshaieva A, Reeves E, Soriano S, Wu Q, Graeber E, Finzer P, Mendling W, Savidge T, Villapol S, Dilthey A, Treangen TJNature methodsEmu: species-level microbial community profiling of full-length 16S rRNA Oxford Nanopore sequencing data. Nat Methods. 2022 07; 19(7):845-853.Nat Methods2022-06-30T00:00:002022Emu: species-level microbial community profiling of full-length 16S rRNA Oxford Nanopore sequencing data.Authorship 10505767Authorship 1050541635820618Gao S, Sun R, Singh R, Yu So S, Chan CTY, Savidge T, Hu MDrug discovery todayThe role of gut microbial ?-glucuronidase in drug disposition and development. Drug Discov Today. 2022 10; 27(10):103316.Drug Discov Today2022-07-09T00:00:002022The role of gut microbial ?-glucuronidase in drug disposition and development.35832621Balaji A, Sapoval N, Seto C, Leo Elworth RA, Fu Y, Nute MG, Savidge T, Segarra S, Treangen TJComputational and structural biotechnology journalKOMB: K-core based de novo characterization of copy number variation in microbiomes. Comput Struct Biotechnol J. 2022; 20:3208-3222.Comput Struct Biotechnol J2022-06-17T00:00:002022KOMB: K-core based de novo characterization of copy number variation in microbiomes.true1Associate ProfessorAssociate Professortrue1ProfessorProfessorAuthorship 121251true1Assistant ProfessorAssistant ProfessorAuthorship 105969412Authorship 10590035Authorship 10604829Authorship 105640816Authorship 10616017Authorship 105694513Authorship 105871913Authorship 1057981636624571Matthews SW, Plantinga A, Burr R, Cain KC, Savidge T, Kamp K, Heitkemper MMBiological research for nursingExploring the Role of Vitamin D and the Gut Microbiome: A Cross-Sectional Study of Individuals with Irritable Bowel Syndrome and Healthy Controls. Biol Res Nurs. 2023 07; 25(3):436-443.Biol Res Nurs2023-01-09T00:00:002023Exploring the Role of Vitamin D and the Gut Microbiome: A Cross-Sectional Study of Individuals with Irritable Bowel Syndrome and Healthy Controls.36541772Simar SR, Tran TT, Rydell KB, Panesso D, Contreras GA, Munita JM, Cifuentes RO, Abbo LM, Sahasrabhojane P, Dinh AQ, Axell-House DB, Savidge T, Shelburne SA, Hanson BM, Arias CAAntimicrobial agents and chemotherapyMultisite Detection of Tn1549-Mediated vanB Vancomycin Resistance in Multidrug-Resistant Enterococcus faecalis ST6 in Texas and Florida. Antimicrob Agents Chemother. 2023 01 24; 67(1):e0128422.Antimicrob Agents Chemother2022-12-21T00:00:002022Multisite Detection of Tn1549-Mediated vanB Vancomycin Resistance in Multidrug-Resistant Enterococcus faecalis ST6 in Texas and Florida.36082768Poon SSB, Hung LY, Wu Q, Parathan P, Yalcinkaya N, Haag A, Luna RA, Bornstein JC, Savidge TC, Foong JPPThe Journal of physiologyNeonatal antibiotics have long term sex-dependent effects on the enteric nervous system. J Physiol. 2022 10; 600(19):4303-4323.J Physiol2022-09-09T00:00:002022Neonatal antibiotics have long term sex-dependent effects on the enteric nervous system.36036505Shropshire WC, Konovalova A, McDaneld P, Gohel M, Strope B, Sahasrabhojane P, Tran CN, Greenberg D, Kim J, Zhan X, Aitken S, Bhatti M, Savidge TC, Treangen TJ, Hanson BM, Arias CA, Shelburne SAmSystemsSystematic Analysis of Mobile Genetic Elements Mediating ?-Lactamase Gene Amplification in Noncarbapenemase-Producing Carbapenem-Resistant Enterobacterales Bloodstream Infections. mSystems. 2022 10 26; 7(5):e0047622.mSystems2022-08-29T00:00:002022Systematic Analysis of Mobile Genetic Elements Mediating ?-Lactamase Gene Amplification in Noncarbapenemase-Producing Carbapenem-Resistant Enterobacterales Bloodstream Infections.36275703Xiao Y, Lian H, Zhong XS, Krishnachaitanya SS, Cong Y, Dashwood RH, Savidge TC, Powell DW, Liu X, Li QFrontiers in immunologyMatrix metalloproteinase 7 contributes to intestinal barrier dysfunction by degrading tight junction protein Claudin-7. Front Immunol. 2022; 13:1020902.Front Immunol2022-10-04T00:00:002022Matrix metalloproteinase 7 contributes to intestinal barrier dysfunction by degrading tight junction protein Claudin-7.36467850Molino S, Pisarevsky A, Badu S, Wu Q, Mingorance FL, Vega P, Stefanolo JP, Repetti J, Ludue?a G, Pepa P, Olmos JI, Fermepin MR, Uehara T, Viciani E, Castagnetti A, Savidge T, Piskorz MMJournal of functional foodsRandomized placebo-controlled trial of oral tannin supplementation on COVID-19 symptoms, gut dysbiosis and cytokine response. J Funct Foods. 2022 Dec; 99:105356.J Funct Foods2022-11-30T00:00:002022Randomized placebo-controlled trial of oral tannin supplementation on COVID-19 symptoms, gut dysbiosis and cytokine response.35919436Chen D, Li Y, Li X, Hong X, Fan X, Savidge TChemical scienceKey difference between transition state stabilization and ground state destabilization: increasing atomic charge densities before or during enzyme-substrate binding. Chem Sci. 2022 Jul 13; 13(27):8193-8202.Chem Sci2022-06-21T00:00:002022Key difference between transition state stabilization and ground state destabilization: increasing atomic charge densities before or during enzyme-substrate binding.33910614Molino S, Pisarevsky A, Mingorance FL, Vega P, Stefanolo JP, Repetti J, Ludue?a G, Pepa P, Olmos JI, Fermepin MR, Uehara T, Villapol S, Savidge T, Treangen T, Viciani E, Castagnetti A, Piskorz MMTrialsNatural tannin extracts supplementation for COVID-19 patients (TanCOVID): a structured summary of a study protocol for a randomized controlled trial. Trials. 2021 Apr 28; 22(1):310.Trials2021-04-28T00:00:002021Natural tannin extracts supplementation for COVID-19 patients (TanCOVID): a structured summary of a study protocol for a randomized controlled trial.Authorship 10640571236780542Plantinga AM, Kamp KJ, Wu Q, Chen L, Yoo L, Burr RL, Cain KC, Raftery D, Carnevale Neto F, Badu S, So SY, Savidge T, Shulman RJ, Heitkemper MMNeurogastroenterology and motilityExploration of associations among dietary tryptophan, microbiome composition and function, and symptom severity in irritable bowel syndrome. Neurogastroenterol Motil. 2023 05; 35(5):e14545.Neurogastroenterol Motil2023-02-13T00:00:002023Exploration of associations among dietary tryptophan, microbiome composition and function, and symptom severity in irritable bowel syndrome.Authorship 10642498Authorship 1064251636823157Tsueng G, Cano MAA, Bento J, Czech C, Kang M, Pache L, Rasmussen LV, Savidge TC, Starren J, Wu Q, Xin J, Yeaman MR, Zhou X, Su AI, Wu C, Brown L, Shabman RS, Hughes LD, NIAID Systems Biology Data Dissemination Working GroupScientific dataDeveloping a standardized but extendable framework to increase the findability of infectious disease datasets. Sci Data. 2023 02 23; 10(1):99.Sci Data2023-02-23T00:00:002023Developing a standardized but extendable framework to increase the findability of infectious disease datasets.36823198Hughes LD, Tsueng G, DiGiovanna J, Horvath TD, Rasmussen LV, Savidge TC, Stoeger T, Turkarslan S, Wu Q, Wu C, Su AI, Pache L, NIAID Systems Biology Data Dissemination Working GroupScientific dataAddressing barriers in FAIR data practices for biomedical data. Sci Data. 2023 02 23; 10(1):98.Sci Data2023-02-23T00:00:002023Addressing barriers in FAIR data practices for biomedical data.Authorship 123401Authorship 10673981136993518Hajjar J, Voigt A, Conner M, Swennes A, Fowler S, Calarge C, Mendonca D, Armstrong D, Chang CY, Walter J, Butte M, Savidge T, Oh J, Kheradmand F, Petrosino JResearch squareCommon Variable Immunodeficiency Patient Fecal Microbiota Transplant Recapitulates Gut Dysbiosis. Res Sq. 2023 Mar 13.Res Sq2023-03-13T00:00:002023Common Variable Immunodeficiency Patient Fecal Microbiota Transplant Recapitulates Gut Dysbiosis. The microbiome and fecal microbiota transplantationAuthorship 10772671137537181Wu Q, Boonma P, Badu S, Yalcinkaya N, So SY, Garey KW, Williams K, Arnold LE, Shulman RJ, Kellermayer R, Savidge TCNPJ biofilms and microbiomesDonor-recipient specificity and age-dependency in fecal microbiota therapy and probiotic resolution of gastrointestinal symptoms. NPJ Biofilms Microbiomes. 2023 08 03; 9(1):54.NPJ Biofilms Microbiomes2023-08-03T00:00:002023Donor-recipient specificity and age-dependency in fecal microbiota therapy and probiotic resolution of gastrointestinal symptoms.true1Distinguished Emeritus ProfessorDistinguished Emeritus Professortrue1ProfessorProfessorAuthorship 10841831037962956Wu Q, Badu S, So SY, Treangen TJ, Savidge TCThe Journal of clinical investigationThe pan-microbiome profiling system Taxa4Meta identifies clinical dysbiotic features and classifies diarrheal disease. J Clin Invest. 2024 Jan 16; 134(2).J Clin Invest2024-01-16T00:00:002024The pan-microbiome profiling system Taxa4Meta identifies clinical dysbiotic features and classifies diarrheal disease.Authorship 1085608938123024So SY, Badu S, Wu Q, Yalcinkaya N, Mirabile Y, Castaneda R, Musaad S, Heitkemper M, Savidge TC, Shulman RJGastroenterologySex-Dependent Efficacy of Dietary Fiber in Pediatric Functional Abdominal Pain. Gastroenterology. 2023 Dec 19.Gastroenterology2023-12-19T00:00:002023Sex-Dependent Efficacy of Dietary Fiber in Pediatric Functional Abdominal Pain.Authorship 219943Authorship 1941611Authorship 337091Authorship 341982Authorship 342928Authorship 31043Authorship 1414162Authorship 142578224412639Sharkey KA, Savidge TCAutonomic neuroscience : basic & clinicalRole of enteric neurotransmission in host defense and protection of the gastrointestinal tract. Auton Neurosci. 2014 Apr; 181:94-106.Auton Neurosci2013-12-22T00:00:002013Role of enteric neurotransmission in host defense and protection of the gastrointestinal tract.24583088Mayer EA, Savidge T, Shulman RJGastroenterologyBrain-gut microbiome interactions and functional bowel disorders. Gastroenterology. 2014 May; 146(6):1500-12.Gastroenterology2014-02-28T00:00:002014Brain-gut microbiome interactions and functional bowel disorders.Authorship 336761Authorship 487251Authorship 493611Authorship 41706Authorship 1455087Authorship 145523224637601Chumpitazi BP, Hollister EB, Oezguen N, Tsai CM, McMeans AR, Luna RA, Savidge TC, Versalovic J, Shulman RJGut microbesGut microbiota influences low fermentable substrate diet efficacy in children with irritable bowel syndrome. Gut Microbes. 2014 Mar-Apr; 5(2):165-75.Gut Microbes2014-01-27T00:00:002014Gut microbiota influences low fermentable substrate diet efficacy in children with irritable bowel syndrome.24674836Sharkey KA, Savidge TCAutonomic neuroscience : basic & clinicalReprint of: Role of enteric neurotransmission in host defense and protection of the gastrointestinal tract. Auton Neurosci. 2014 May; 182:70-82.Auton Neurosci2014-03-15T00:00:002014Reprint of: Role of enteric neurotransmission in host defense and protection of the gastrointestinal tract.Authorship 6099424999042Couturier J, Hutchison AT, Medina MA, Gingaras C, Urvil P, Yu X, Nguyen C, Mahale P, Lin L, Kozinetz CA, Schmitz JE, Kimata JT, Savidge TC, Lewis DEVirologyHIV replication in conjunction with granzyme B production by CCR5+ memory CD4 T cells: Implications for bystander cell and tissue pathologies. Virology. 2014 Aug; 462-463:175-88.Virology2014-07-04T00:00:002014HIV replication in conjunction with granzyme B production by CCR5+ memory CD4 T cells: Implications for bystander cell and tissue pathologies.Authorship 701021Authorship 14753113Authorship 724339Authorship 540497Authorship 573444Authorship 816116Authorship 660316Authorship 669081Authorship 676553Authorship 702653Authorship 760264Authorship 1548264