HAMEDJAFAR-NEJADHAMED JAFAR-NEJAD29.71073630000000-95.396604500000003802JAFAR-NEJAD, HAMEDProfessorprns:coAuthorOfcoauthor ofprns:endDateend dateFaculty Rankprns:fullNamefull nameprns:grantAwardedBygrant awarded byprns:hasAuthorListauthor listprns:hasFacultyRankhas faculty rankprns:hasNetworkhas networkprns:hasPublicationVenuepublished inprns:informationResourceReferenceinformation resource referenceprns:isPrimaryPositionis primary positionprns:latitudelatitudeprns:longitudelongitudeprns:mainImagephotoprns:maxWeightmaximum weightprns:medlineTAjournal title abbreviationprns:meshDescriptorUIMeSH DescriptorUIprns:meshSemanticGroupNameMeSH semantic group nameprns:minWeightminimum weightprns:numberOfAuthorsnumber of authorsprns:numberOfConnectionsnumber of connectionsprns:numberOfPublicationsnumber of publicationsprns:personIdPerson IDprns:personInPrimaryPositionperson in primary positionprns:physicalNeighborOfphysical neighborprns:positionInDepartmentposition in departmentprns:positionInDivisionposition in divisionprns:predicateNodepredicate nodeprns:principalInvestigatorNameprincipal investigator nameprns:publicationDatepublication dateprns:similarTosimilar toprns:sortOrdersort orderprns:startDatestart dateprns:uniquenessWeightuniqueness weightprns:yearyearAcademic ArticleArticleDocumentbibo:pmidPubMed IdentifierAddressvivo:address1address line 1vivo:addressCitycityvivo:addressPostalCodepostal codevivo:addressStatestate or provinceAgreementvivo:authorInAuthorshipselected publicationsvivo:authorRankauthor rank in publicationAuthorshipDepartmentDivisionGrantvivo:hasMemberRolemember ofvivo:hasResearchArearesearch areasvivo:hasResearcherRoleresearch activitiesvivo:hrJobTitleHR job titleInformation Resourcevivo:linkAnchorTextlink anchor textvivo:linkedAuthorlinked authorvivo:linkedInformationResourcelinked information resourcevivo:mailingAddressmailing addressMember Rolevivo:memberRoleOfmember role ofvivo:personInPositionpositionsPositionvivo:positionInOrganizationposition in organizationvivo:preferredTitlepreferred titleResearcher Rolevivo:researcherRoleOfresearcher role ofRolevivo:roleContributesTocontributes tovivo:sponsorAwardIdsponsor award idURLLinkvivo:webpagewebpagerdf:predicatepredicaterdf:typetyperdfs:labellabelConceptAgentfoaf:firstNamefirst nameGroupfoaf:lastNamelast nameOrganizationPerson25412384Haltom AR, Lee TV, Harvey BM, Leonardi J, Chen YJ, Hong Y, Haltiwanger RS, Jafar-Nejad HPLoS geneticsThe protein O-glucosyltransferase Rumi modifies eyes shut to promote rhabdomere separation in Drosophila. PLoS Genet. 2014 Nov; 10(11):e1004795.PLoS Genet2014-11-20T00:00:002014The protein O-glucosyltransferase Rumi modifies eyes shut to promote rhabdomere separation in Drosophila.Authorship 795937Authorship 33048Authorship 539683Authorship 558658Authorship 763867Authorship 824407ASHUTOSHPANDEYASHUTOSH PANDEY10993PANDEY, ASHUTOSHAssistant ProfessorAuthorship 2942335Authorship 2969352Authorship 298518725900930He P, Grotzke JE, Ng BG, Gunel M, Jafar-Nejad H, Cresswell P, Enns GM, Freeze HHGlycobiologyA congenital disorder of deglycosylation: Biochemical characterization of N-glycanase 1 deficiency in patient fibroblasts. Glycobiology. 2015 Aug; 25(8):836-44.Glycobiology2015-04-21T00:00:002015A congenital disorder of deglycosylation: Biochemical characterization of N-glycanase 1 deficiency in patient fibroblasts.26175457Haltom AR, Jafar-Nejad HGlycobiologyThe multiple roles of epidermal growth factor repeat O-glycans in animal development. Glycobiology. 2015 Oct; 25(10):1027-42.Glycobiology2015-07-14T00:00:002015The multiple roles of epidermal growth factor repeat O-glycans in animal development.26235536Thakurdas SM, Lopez MF, Kakuda S, Fernandez-Valdivia R, Zarrin-Khameh N, Haltiwanger RS, Jafar-Nejad HHepatology (Baltimore, Md.)Jagged1 heterozygosity in mice results in a congenital cholangiopathy which is reversed by concomitant deletion of one copy of Poglut1 (Rumi). Hepatology. 2016 Feb; 63(2):550-65.Hepatology2015-10-20T00:00:002015Jagged1 heterozygosity in mice results in a congenital cholangiopathy which is reversed by concomitant deletion of one copy of Poglut1 (Rumi).12917378Ou XM, Lemonde S, Jafar-Nejad H, Bown CD, Goto A, Rogaeva A, Albert PRThe Journal of neuroscience : the official journal of the Society for NeuroscienceFreud-1: A neuronal calcium-regulated repressor of the 5-HT1A receptor gene. J Neurosci. 2003 Aug 13; 23(19):7415-25.J Neurosci2003-08-13T00:00:002003Freud-1: A neuronal calcium-regulated repressor of the 5-HT1A receptor gene.14665671Jafar-Nejad H, Acar M, Nolo R, Lacin H, Pan H, Parkhurst SM, Bellen HJGenes & developmentSenseless acts as a binary switch during sensory organ precursor selection. Genes Dev. 2003 Dec 01; 17(23):2966-78.Genes Dev2003-12-01T00:00:002003Senseless acts as a binary switch during sensory organ precursor selection.15084454Quan XJ, Denayer T, Yan J, Jafar-Nejad H, Philippi A, Lichtarge O, Vleminckx K, Hassan BADevelopment (Cambridge, England)Evolution of neural precursor selection: functional divergence of proneural proteins. Development. 2004 Apr; 131(8):1679-89.Development2004-03-17T00:00:002004Evolution of neural precursor selection: functional divergence of proneural proteins.10713139Ou XM, Jafar-Nejad H, Storring JM, Meng JH, Lemonde S, Albert PRThe Journal of biological chemistryNovel dual repressor elements for neuronal cell-specific transcription of the rat 5-HT1A receptor gene. J Biol Chem. 2000 Mar 17; 275(11):8161-8.J Biol Chem2000-03-17T00:00:002000Novel dual repressor elements for neuronal cell-specific transcription of the rat 5-HT1A receptor gene.74Professor10Assistant Professor14Associate Professor6Adjunct Professor47Distinguished Service ProfessorAuthorship 324684527268051Harvey BM, Rana NA, Moss H, Leonardi J, Jafar-Nejad H, Haltiwanger RSThe Journal of biological chemistryMapping Sites of O-Glycosylation and Fringe Elongation on Drosophila Notch. J Biol Chem. 2016 07 29; 291(31):16348-60.J Biol Chem2016-06-06T00:00:002016Mapping Sites of O-Glycosylation and Fringe Elongation on Drosophila Notch.One Baylor PlazaHouston, 77030TX12960394Zhai RG, Hiesinger PR, Koh TW, Verstreken P, Schulze KL, Cao Y, Jafar-Nejad H, Norga KK, Pan H, Bayat V, Greenbaum MP, Bellen HJProceedings of the National Academy of Sciences of the United States of AmericaMapping Drosophila mutations with molecularly defined P element insertions. Proc Natl Acad Sci U S A. 2003 Sep 16; 100(19):10860-5.Proc Natl Acad Sci U S A2003-09-05T00:00:002003Mapping Drosophila mutations with molecularly defined P element insertions.Seung YeopHanSeung Yeop Han0.000000000000000.000000000000005404Han, Seung YeopPostdoc Fellows and Associates20816218Lee TV, Takeuchi H, Jafar-Nejad HMethods in enzymologyRegulation of notch signaling via O-glucosylation insights from Drosophila studies. Methods Enzymol. 2010; 480:375-98.Methods Enzymol2010-01-01T00:00:002010Regulation of notch signaling via O-glucosylation insights from Drosophila studies.16341207Hamaratoglu F, Willecke M, Kango-Singh M, Nolo R, Hyun E, Tao C, Jafar-Nejad H, Halder GNature cell biologyThe tumour-suppressor genes NF2/Merlin and Expanded act through Hippo signalling to regulate cell proliferation and apoptosis. Nat Cell Biol. 2006 Jan; 8(1):27-36.Nat Cell Biol2005-12-11T00:00:002005The tumour-suppressor genes NF2/Merlin and Expanded act through Hippo signalling to regulate cell proliferation and apoptosis.21490058Fernandez-Valdivia R, Takeuchi H, Samarghandi A, Lopez M, Leonardi J, Haltiwanger RS, Jafar-Nejad HDevelopment (Cambridge, England)Regulation of mammalian Notch signaling and embryonic development by the protein O-glucosyltransferase Rumi. Development. 2011 May; 138(10):1925-34.Development2011-04-13T00:00:002011Regulation of mammalian Notch signaling and embryonic development by the protein O-glucosyltransferase Rumi.16122429Tsuda H, Jafar-Nejad H, Patel AJ, Sun Y, Chen HK, Rose MF, Venken KJ, Botas J, Orr HT, Bellen HJ, Zoghbi HYCellThe AXH domain of Ataxin-1 mediates neurodegeneration through its interaction with Gfi-1/Senseless proteins. Cell. 2005 Aug 26; 122(4):633-44.Cell2005-08-26T00:00:002005The AXH domain of Ataxin-1 mediates neurodegeneration through its interaction with Gfi-1/Senseless proteins.16137928Jafar-Nejad H, Andrews HK, Acar M, Bayat V, Wirtz-Peitz F, Mehta SQ, Knoblich JA, Bellen HJDevelopmental cellSec15, a component of the exocyst, promotes notch signaling during the asymmetric division of Drosophila sensory organ precursors. Dev Cell. 2005 Sep; 9(3):351-63.Dev Cell2005-09-01T00:00:002005Sec15, a component of the exocyst, promotes notch signaling during the asymmetric division of Drosophila sensory organ precursors.16624856Acar M, Jafar-Nejad H, Giagtzoglou N, Yallampalli S, David G, He Y, Delidakis C, Bellen HJDevelopment (Cambridge, England)Senseless physically interacts with proneural proteins and functions as a transcriptional co-activator. Development. 2006 May; 133(10):1979-89.Development2006-04-19T00:00:002006Senseless physically interacts with proneural proteins and functions as a transcriptional co-activator.23754965Lee TV, Sethi MK, Leonardi J, Rana NA, Buettner FF, Haltiwanger RS, Bakker H, Jafar-Nejad HPLoS geneticsNegative regulation of notch signaling by xylose. PLoS Genet. 2013 Jun; 9(6):e1003547.PLoS Genet2013-06-06T00:00:002013Negative regulation of notch signaling by xylose.17535813Rogaeva A, Ou XM, Jafar-Nejad H, Lemonde S, Albert PRThe Journal of biological chemistryDifferential repression by freud-1/CC2D1A at a polymorphic site in the dopamine-D2 receptor gene. J Biol Chem. 2007 Jul 20; 282(29):20897-905.J Biol Chem2007-05-29T00:00:002007Differential repression by freud-1/CC2D1A at a polymorphic site in the dopamine-D2 receptor gene.18758436Lim J, Jafar-Nejad H, Hsu YC, Choi KWEMBO reportsNovel function of the class I bHLH protein Daughterless in the negative regulation of proneural gene expression in the Drosophila eye. EMBO Rep. 2008 Nov; 9(11):1128-33.EMBO Rep2008-08-29T00:00:002008Novel function of the class I bHLH protein Daughterless in the negative regulation of proneural gene expression in the Drosophila eye.Authorship 653861727807076Servi?n-Morilla E, Takeuchi H, Lee TV, Clarimon J, Mavillard F, Area-G?mez E, Rivas E, Nieto-Gonz?lez JL, Rivero MC, Cabrera-Serrano M, G?mez-S?nchez L, Mart?nez-L?pez JA, Estrada B, M?rquez C, Morgado Y, Su?rez-Calvet X, Pita G, Bigot A, Gallardo E, Fern?ndez-Chac?n R, Hirano M, Haltiwanger RS, Jafar-Nejad H, Paradas CEMBO molecular medicineA POGLUT1 mutation causes a muscular dystrophy with reduced Notch signaling and satellite cell loss. EMBO Mol Med. 2016 11; 8(11):1289-1309.EMBO Mol Med2016-11-02T00:00:002016A POGLUT1 mutation causes a muscular dystrophy with reduced Notch signaling and satellite cell loss.20368670Jafar-Nejad H, Leonardi J, Fernandez-Valdivia RGlycobiologyRole of glycans and glycosyltransferases in the regulation of Notch signaling. Glycobiology. 2010 Aug; 20(8):931-49.Glycobiology2010-04-05T00:00:002010Role of glycans and glycosyltransferases in the regulation of Notch signaling.21771811Leonardi J, Fernandez-Valdivia R, Li YD, Simcox AA, Jafar-Nejad HDevelopment (Cambridge, England)Multiple O-glucosylation sites on Notch function as a buffer against temperature-dependent loss of signaling. Development. 2011 Aug; 138(16):3569-78.Development2011-07-19T00:00:002011Multiple O-glucosylation sites on Notch function as a buffer against temperature-dependent loss of signaling.Authorship 868987328394891Lee TV, Pandey A, Jafar-Nejad HPLoS geneticsXylosylation of the Notch receptor preserves the balance between its activation by trans-Delta and inhibition by cis-ligands in Drosophila. PLoS Genet. 2017 04; 13(4):e1006723.PLoS Genet2017-04-10T00:00:002017Xylosylation of the Notch receptor preserves the balance between its activation by trans-Delta and inhibition by cis-ligands in Drosophila.15456856Jafar-Nejad H, Bellen HJMolecular and cellular biologyGfi/Pag-3/senseless zinc finger proteins: a unifying theme? Mol Cell Biol. 2004 Oct; 24(20):8803-12.Mol Cell Biol2004-10-01T00:00:002004Gfi/Pag-3/senseless zinc finger proteins: a unifying theme?16554363Jafar-Nejad H, Tien AC, Acar M, Bellen HJDevelopment (Cambridge, England)Senseless and Daughterless confer neuronal identity to epithelial cells in the Drosophila wing margin. Development. 2006 May; 133(9):1683-92.Development2006-03-22T00:00:002006Senseless and Daughterless confer neuronal identity to epithelial cells in the Drosophila wing margin.18243100Acar M, Jafar-Nejad H, Takeuchi H, Rajan A, Ibrani D, Rana NA, Pan H, Haltiwanger RS, Bellen HJCellRumi is a CAP10 domain glycosyltransferase that modifies Notch and is required for Notch signaling. Cell. 2008 Jan 25; 132(2):247-58.Cell2008-01-25T00:00:002008Rumi is a CAP10 domain glycosyltransferase that modifies Notch and is required for Notch signaling.19077546Simcox AA, Austin CL, Jacobsen TL, Jafar-Nejad HFlyDrosophila embryonic 'fibroblasts': extending mutant analysis in vitro. Fly (Austin). 2008 Nov-Dec; 2(6):306-9.Fly (Austin)2008-11-15T00:00:002008Drosophila embryonic 'fibroblasts': extending mutant analysis in vitro.21949356Takeuchi H, Fern?ndez-Valdivia RC, Caswell DS, Nita-Lazar A, Rana NA, Garner TP, Weldeghiorghis TK, Macnaughtan MA, Jafar-Nejad H, Haltiwanger RSProceedings of the National Academy of Sciences of the United States of AmericaRumi functions as both a protein O-glucosyltransferase and a protein O-xylosyltransferase. Proc Natl Acad Sci U S A. 2011 Oct 04; 108(40):16600-5.Proc Natl Acad Sci U S A2011-09-26T00:00:002011Rumi functions as both a protein O-glucosyltransferase and a protein O-xylosyltransferase.Authorship 8792345Authorship 8812206Authorship 882904228826503Galeone A, Han SY, Huang C, Hosomi A, Suzuki T, Jafar-Nejad HeLifeTissue-specific regulation of BMP signaling by Drosophila N-glycanase 1. Elife. 2017 08 04; 6.Elife2017-08-04T00:00:002017Tissue-specific regulation of BMP signaling by Drosophila N-glycanase 1.29034878Wu J, Hunt SD, Matthias N, Servi?n-Morilla E, Lo J, Jafar-Nejad H, Paradas C, Darabi RStem cell researchGeneration of an induced pluripotent stem cell line (CSCRMi001-A) from a patient with a new type of limb-girdle muscular dystrophy (LGMD) due to a missense mutation in POGLUT1 (Rumi). Stem Cell Res. 2017 10; 24:102-105.Stem Cell Res2017-09-01T00:00:002017Generation of an induced pluripotent stem cell line (CSCRMi001-A) from a patient with a new type of limb-girdle muscular dystrophy (LGMD) due to a missense mutation in POGLUT1 (Rumi).29364239Pandey A, Jafar-Nejad HJournal of visualized experiments : JoVECell Aggregation Assays to Evaluate the Binding of the Drosophila Notch with Trans-Ligands and its Inhibition by Cis-Ligands. J Vis Exp. 2018 01 02; (131).J Vis Exp2018-01-02T00:00:002018Cell Aggregation Assays to Evaluate the Binding of the Drosophila Notch with Trans-Ligands and its Inhibition by Cis-Ligands.true1ProfessorProfessortrue1Associate ProfessorAssociate Professortrue1ProfessorProfessortrue1Assistant ProfessorAssistant ProfessorD005964Chemicals & Drugs32540.957138GlucosyltransferasesD029721Chemicals & Drugs2288520.604861Drosophila ProteinsD043524Chemicals & Drugs12210.967233Peptide-N4-(N-acetyl-beta-glucosaminyl) Asparagine AmidaseAuthorship 1075213D051880Chemicals & Drugs2153830.767444Receptors, NotchAuthorship 9150032Authorship 9165047Authorship 938115229425927Adams JM, Jafar-Nejad HGastroenterologyA New Model of Alagille Syndrome With Broad Phenotypic Representation. Gastroenterology. 2018 03; 154(4):803-806.Gastroenterology2018-02-06T00:00:002018A New Model of Alagille Syndrome With Broad Phenotypic Representation.30169771Pandey A, Li-Kroeger D, Sethi MK, Lee TV, Buettner FF, Bakker H, Jafar-Nejad HGlycobiologySensitized genetic backgrounds reveal differential roles for EGF repeat xylosyltransferases in Drosophila Notch signaling. Glycobiology. 2018 11 01; 28(11):849-859.Glycobiology2018-11-01T00:00:002018Sensitized genetic backgrounds reveal differential roles for EGF repeat xylosyltransferases in Drosophila Notch signaling.30528322Niknejad N, Jafar-Nejad HTranslational research : the journal of laboratory and clinical medicineUnbiased glycomics: a powerful tool in rare disease diagnosis and research. Transl Res. 2019 04; 206:1-4.Transl Res2018-11-24T00:00:002018Unbiased glycomics: a powerful tool in rare disease diagnosis and research.2021-06-30NIHJAFAR-NEJAD, HAMED2016-07-15Negative regulation of Jagged1 by glycosylation: towards a mechanism-based therapy for Alagille syndromeR01DK1099822018-12-31NIHJAFAR-NEJAD, HAMED2008-04-01Fine-Tuning the Notch Signaling Pathway via O-GlucosylationR01GM084135Principal InvestigatorPrincipal InvestigatorD004330Living Beings2288180.663794DrosophilaDepartment of NeurologyDepartment of Molecular & Cellular BiologyDepartment of Molecular & Human GeneticsDepartment of Pathology & ImmunologyMolecular & Cellular BiologyMolecular & Human GeneticsNeurologyPathologyBaylor College of MedicineDAVIDBATESDAVID BATES29.71073630000000-95.396604500000001204BATES, DAVIDAssociate ProfessorRONALDDAVISRONALD DAVIS0.000000000000000.000000000000003208DAVIS, RONALDAdjunct ProfessorGRAEMEMARDONGRAEME MARDON0.000000000000000.000000000000003439MARDON, GRAEMEProfessorHUGOBELLENHUGO BELLEN29.71010310000000-95.397396100000003292BELLEN, HUGODistinguished Service ProfessorPHILIPHASTINGSPHILIP HASTINGS29.71073630000000-95.396604500000003556HASTINGS, PHILIPProfessor2024-01-31NIHJAFAR-NEJAD, HAMED2019-02-01Regulation of developmental signaling pathways by glycosylation and deglycosylationR35GM130317Principal InvestigatorGRZEGORZIRAGRZEGORZ IRA29.71073630000000-95.39660450000000927IRA, GRZEGORZProfessorBENNYKAIPPARETTUBENNY KAIPPARETTU29.71073630000000-95.39660450000000970KAIPPARETTU, BENNYAssociate ProfessorDAVIDNELSONDAVID NELSON29.71073630000000-95.396604500000003130NELSON, DAVIDProfessorNEDAZARRIN-KHAMEHNEDA ZARRIN-KHAMEH0.000000000000000.00000000000000349ZARRIN-KHAMEH, NEDAProfessor111groups5.500710.00561259235research areas7.055950.015592413coauthor of202.6359.7200860similar to1150selected publicationsAuthorship 947534231107443Adams JM, Jafar-Nejad HJournal of visualized experiments : JoVEDetermining Bile Duct Density in the Mouse Liver. J Vis Exp. 2019 04 30; (146).J Vis Exp2019-04-30T00:00:002019Determining Bile Duct Density in the Mouse Liver.Authorship 9546591031469182Adams JM, Huppert KA, Castro EC, Lopez MF, Niknejad N, Subramanian S, Zarrin-Khameh N, Finegold MJ, Huppert SS, Jafar-Nejad HHepatology (Baltimore, Md.)Sox9 Is a Modifier of the Liver Disease Severity in a Mouse Model of Alagille Syndrome. Hepatology. 2020 04; 71(4):1331-1349.Hepatology2020-01-24T00:00:002020Sox9 Is a Modifier of the Liver Disease Severity in a Mouse Model of Alagille Syndrome.Dr. Shaulsky's GroupMemberAuthorship 957284231615106Adams JM, Jafar-Nejad HBiomoleculesThe Roles of Notch Signaling in Liver Development and Disease. Biomolecules. 2019 10 14; 9(10).Biomolecules2019-10-14T00:00:002019The Roles of Notch Signaling in Liver Development and Disease.true1Adjunct ProfessorAdjunct Professortrue1ProfessorProfessortrue1ProfessorProfessortrue1ProfessorProfessortrue1Associate ProfessorAssociate ProfessorAuthorship 1085402Authorship 960948631722217Pandey A, Harvey BM, Lopez MF, Ito A, Haltiwanger RS, Jafar-Nejad HCell reportsGlycosylation of Specific Notch EGF Repeats by O-Fut1 and Fringe Regulates Notch Signaling in Drosophila. Cell Rep. 2019 11 12; 29(7):2054-2066.e6.Cell Rep2019-11-12T00:00:002019Glycosylation of Specific Notch EGF Repeats by O-Fut1 and Fringe Regulates Notch Signaling in Drosophila.Authorship 9751271831897643Servi?n-Morilla E, Cabrera-Serrano M, Johnson K, Pandey A, Ito A, Rivas E, Chamova T, Muelas N, Mongini T, Nafissi S, Claeys KG, Grewal RP, Takeuchi M, Hao H, B?nnemann C, Lopes Abath Neto O, Medne L, Brandsema J, T?pf A, Taneva A, Vilchez JJ, Tournev I, Haltiwanger RS, Takeuchi H, Jafar-Nejad H, Straub V, Paradas CActa neuropathologicaPOGLUT1 biallelic mutations cause myopathy with reduced satellite cells, a-dystroglycan hypoglycosylation and a distinctive radiological pattern. Acta Neuropathol. 2020 03; 139(3):565-582.Acta Neuropathol2020-01-03T00:00:002020POGLUT1 biallelic mutations cause myopathy with reduced satellite cells, a-dystroglycan hypoglycosylation and a distinctive radiological pattern.71Postdoc Fellows and AssociatesPostDocSHINYAYAMAMOTOSHINYA YAMAMOTO0.000000000000000.000000000000005831YAMAMOTO, SHINYAAssistant ProfessorTOMLEETOM LEE0.000000000000000.000000000000005724LEE, TOMAssistant ProfessorAuthorship 1154121Authorship 990508332472127Pandey A, Niknejad N, Jafar-Nejad HGlycobiologyMultifaceted regulation of Notch signaling by glycosylation. Glycobiology. 2021 01 09; 31(1):8-28.Glycobiology2021-01-09T00:00:002021Multifaceted regulation of Notch signaling by glycosylation.2025-06-30NIHDARABI, RADBOD ;JAFAR-NEJAD, HAMED2020-07-08REGULATION OF SKELETAL MUSCLE DEVELOPMENT AND MAINTENANCE BY PROTEIN O-GLUCOSYLTRANSFERASE 1 (POGLUT1)R01AR076770Principal InvestigatorAuthorship 9955491432720893Galeone A, Adams JM, Matsuda S, Presa MF, Pandey A, Han SY, Tachida Y, Hirayama H, Vaccari T, Suzuki T, Lutz CM, Affolter M, Zuberi A, Jafar-Nejad HeLifeRegulation of BMP4/Dpp retrotranslocation and signaling by deglycosylation. Elife. 2020 07 28; 9.Elife2020-07-28T00:00:002020Regulation of BMP4/Dpp retrotranslocation and signaling by deglycosylation.http://flypush.imgen.bcm.tmc.eduBellen Lab WebsiteAuthorship 1007284733315951Han SY, Pandey A, Moore T, Galeone A, Duraine L, Cowan TM, Jafar-Nejad HPLoS geneticsA conserved role for AMP-activated protein kinase in NGLY1 deficiency. PLoS Genet. 2020 12; 16(12):e1009258.PLoS Genet2020-12-14T00:00:002020A conserved role for AMP-activated protein kinase in NGLY1 deficiency.true1ProfessorProfessorAuthorship 1025247234270726Pandey A, Jafar-Nejad HJournal of biochemistryTracing the NGLY1 footprints: insights from Drosophila. J Biochem. 2022 Feb 21; 171(2):153-160.J Biochem2022-02-21T00:00:002022Tracing the NGLY1 footprints: insights from Drosophila.true1Distinguished Service ProfessorDistinguished Service ProfessorAuthorship 1179764Authorship 1043713435406718Pandey A, Adams JM, Han SY, Jafar-Nejad HCellsNGLY1 Deficiency, a Congenital Disorder of Deglycosylation: From Disease Gene Function to Pathophysiology. Cells. 2022 03 29; 11(7).Cells2022-03-29T00:00:002022NGLY1 Deficiency, a Congenital Disorder of Deglycosylation: From Disease Gene Function to Pathophysiology.true1Assistant ProfessorAssistant Professortrue1Postdoc Fellows and AssociatesPostdoc Fellows and AssociatesAuthorship 168752true1Assistant ProfessorAssistant ProfessorAuthorship 10682259Authorship 10680091337021797Niknejad N, Fox D, Burwinkel JL, Zarrin-Khameh N, Cho S, Soriano A, Cast AE, Lopez MF, Huppert KA, Rigo F, Huppert SS, Jafar-Nejad P, Jafar-Nejad HHepatology (Baltimore, Md.)ASO silencing of a glycosyltransferase, Poglut1 , improves the liver phenotypes in mouse models of Alagille syndrome. Hepatology. 2023 11 01; 78(5):1337-1351.Hepatology2023-04-07T00:00:002023ASO silencing of a glycosyltransferase, Poglut1 , improves the liver phenotypes in mouse models of Alagille syndrome.37066398Pandey A, Galeone A, Han SY, Story BA, Consonni G, Mueller WF, Steinmetz LM, Vaccari T, Jafar-Nejad HbioRxiv : the preprint server for biologyGut barrier defects, increased intestinal innate immune response, and enhanced lipid catabolism drive lethality in N -glycanase 1 deficient Drosophila. bioRxiv. 2023 Apr 07.bioRxiv2023-04-07T00:00:002023Gut barrier defects, increased intestinal innate immune response, and enhanced lipid catabolism drive lethality in N -glycanase 1 deficient Drosophila.Authorship 10775779Authorship 1078320937704604Pandey A, Galeone A, Han SY, Story BA, Consonni G, Mueller WF, Steinmetz LM, Vaccari T, Jafar-Nejad HNature communicationsGut barrier defects, intestinal immune hyperactivation and enhanced lipid catabolism drive lethality in NGLY1-deficient Drosophila. Nat Commun. 2023 09 13; 14(1):5667.Nat Commun2023-09-13T00:00:002023Gut barrier defects, intestinal immune hyperactivation and enhanced lipid catabolism drive lethality in NGLY1-deficient Drosophila.37650119Ortiz-Vitali JL, Wu J, Xu N, Shieh AW, Niknejad N, Takeuchi M, Paradas C, Lin C, Jafar-Nejad H, Haltiwanger RS, Wang SH, Darabi RMolecular therapy. Nucleic acidsDisease modeling and gene correction of LGMDR21 iPSCs elucidates the role of POGLUT1 in skeletal muscle maintenance, regeneration, and the satellite cell niche. Mol Ther Nucleic Acids. 2023 Sep 12; 33:683-697.Mol Ther Nucleic Acids2023-08-02T00:00:002023Disease modeling and gene correction of LGMDR21 iPSCs elucidates the role of POGLUT1 in skeletal muscle maintenance, regeneration, and the satellite cell niche.Authorship 196492Authorship 225611Authorship 437044Authorship 342351Authorship 613962Authorship 46052Authorship 148306225053479Leonardi J, Jafar-Nejad HMethods in molecular biology (Clifton, N.J.)Structure-function analysis of Drosophila Notch using genomic rescue transgenes. Methods Mol Biol. 2014; 1187:29-46.Methods Mol Biol2014-01-01T00:00:002014Structure-function analysis of Drosophila Notch using genomic rescue transgenes.Authorship 799971Authorship 83305Authorship 151252425255098LeBon L, Lee TV, Sprinzak D, Jafar-Nejad H, Elowitz MBeLifeFringe proteins modulate Notch-ligand cis and trans interactions to specify signaling states. Elife. 2014 Sep 25; 3:e02950.Elife2014-09-25T00:00:002014Fringe proteins modulate Notch-ligand cis and trans interactions to specify signaling states.Authorship 966781Authorship 746243Authorship 1557328