MARGARETGOODELLMARGARET GOODELL18.5472050000000073.831670200000003548GOODELL, MARGARETProfessorplugins:TwitterTwitterprns:coAuthorOfcoauthor ofprns:endDateend dateFaculty Rankprns:fullNamefull nameprns:grantAwardedBygrant awarded byprns:hasAuthorListauthor listprns:hasFacultyRankhas faculty rankprns:hasNetworkhas networkprns:hasPublicationVenuepublished inprns:informationResourceReferenceinformation resource referenceprns:isPrimaryPositionis primary positionprns:latitudelatitudeprns:longitudelongitudeprns:mainImagephotoprns:maxWeightmaximum weightprns:medlineTAjournal title abbreviationprns:meshDescriptorUIMeSH DescriptorUIprns:meshSemanticGroupNameMeSH semantic group nameprns:minWeightminimum weightprns:numberOfAuthorsnumber of authorsprns:numberOfConnectionsnumber of connectionsprns:numberOfPublicationsnumber of publicationsprns:personIdPerson IDprns:personInPrimaryPositionperson in primary positionprns:physicalNeighborOfphysical neighborprns:pluginSearchableDataProfilesRNS Plugin Searchable Dataprns:positionInDepartmentposition in departmentprns:positionInDivisionposition in divisionprns:predicateNodepredicate nodeprns:principalInvestigatorNameprincipal investigator nameprns:publicationDatepublication dateprns:similarTosimilar toprns:sortOrdersort orderprns:startDatestart dateprns:uniquenessWeightuniqueness weightprns:yearyearAcademic ArticleArticleDocumentbibo:pmidPubMed IdentifierAddressvivo:address1address line 1vivo:addressCitycityvivo:addressPostalCodepostal codevivo:addressStatestate or provinceAgreementvivo:authorInAuthorshipselected publicationsvivo:authorRankauthor rank in publicationAuthorshipDepartmentDivisionGrantvivo:hasMemberRolemember ofvivo:hasResearchArearesearch areasvivo:hasResearcherRoleresearch activitiesvivo:hrJobTitleHR job titleInformation Resourcevivo:linkAnchorTextlink anchor textvivo:linkedAuthorlinked authorvivo:linkedInformationResourcelinked information resourcevivo:mailingAddressmailing addressMember Rolevivo:memberRoleOfmember role ofvivo:orcidIdORCID idvivo:personInPositionpositionsPositionvivo:positionInOrganizationposition in organizationvivo:preferredTitlepreferred titleResearcher Rolevivo:researcherRoleOfresearcher role ofRolevivo:roleContributesTocontributes tovivo:sponsorAwardIdsponsor award idURLLinkvivo:webpagewebpagerdf:predicatepredicaterdf:typetyperdfs:labellabelConceptAgentfoaf:firstNamefirst nameGroupfoaf:lastNamelast nameOrganizationPersonAuthorship 80935Authorship 826502Authorship 8781114Authorship 92693Authorship 94902Authorship 955673Authorship 964943Authorship 1006515Authorship 1045538Authorship 248132Authorship 16044011Authorship 1618122Authorship 1618771Authorship 16189112Authorship 1626273Authorship 163031125416277Mayle A, Yang L, Rodriguez B, Zhou T, Chang E, Curry CV, Challen GA, Li W, Wheeler D, Rebel VI, Goodell MABloodDnmt3a loss predisposes murine hematopoietic stem cells to malignant transformation. Blood. 2015 Jan 22; 125(4):629-38.Blood2015-01-22T00:00:002015Dnmt3a loss predisposes murine hematopoietic stem cells to malignant transformation.25693834Yang L, Rau R, Goodell MANature reviews. CancerDNMT3A in haematological malignancies. Nat Rev Cancer. 2015 Mar; 15(3):152-65.Nat Rev Cancer2015-02-19T00:00:002015DNMT3A in haematological malignancies.25714123Cullen SM, Goodell MACell cycle (Georgetown, Tex.)Dynamic DNA methylation discovered during HSC differentiation. Cell Cycle. 2015; 14(5):693-4.Cell Cycle2015-01-01T00:00:002015Dynamic DNA methylation discovered during HSC differentiation.25762178Goodell MBloodIntroduction to a review series on hematopoietic stem cells. Blood. 2015 Apr 23; 125(17):2587.Blood2015-03-11T00:00:002015Introduction to a review series on hematopoietic stem cells.25772072Luo M, Jeong M, Sun D, Park HJ, Rodriguez BA, Xia Z, Yang L, Zhang X, Sheng K, Darlington GJ, Li W, Goodell MACell stem cellLong non-coding RNAs control hematopoietic stem cell function. Cell Stem Cell. 2015 Apr 02; 16(4):426-38.Cell Stem Cell2015-03-12T00:00:002015Long non-coding RNAs control hematopoietic stem cell function.25907613Goodell MA, Nguyen H, Shroyer NNature reviews. Molecular cell biologySomatic stem cell heterogeneity: diversity in the blood, skin and intestinal stem cell compartments. Nat Rev Mol Cell Biol. 2015 May; 16(5):299-309.Nat Rev Mol Cell Biol2015-05-01T00:00:002015Somatic stem cell heterogeneity: diversity in the blood, skin and intestinal stem cell compartments.Authorship 269242Authorship 2904313Authorship 332914Authorship 351553Authorship 385247LeukemiaStem Cell TransplantationMD AndersonELIZABETHSHPALLELIZABETH SHPALL9025SHPALL, ELIZABETHProfessorMICHAELANDREEFFMICHAEL ANDREEFF8437ANDREEFF, MICHAELProfessorHAGOP MKANTARJIANHAGOP M KANTARJIAN8501KANTARJIAN, HAGOP MProfessorGUILLERMOGARCIA-MANEROGUILLERMO GARCIA-MANERO8853GARCIA-MANERO, GUILLERMOProfessorAuthorship 4114Authorship 4515710Authorship 593013Authorship 2755013125993969Wang J, Wegener JE, Huang TW, Sripathy S, De Jesus-Cortes H, Xu P, Tran S, Knobbe W, Leko V, Britt J, Starwalt R, McDaniel L, Ward CS, Parra D, Newcomb B, Lao U, Nourigat C, Flowers DA, Cullen S, Jorstad NL, Yang Y, Glaskova L, Vingeau S, Vigneau S, Kozlitina J, Yetman MJ, Jankowsky JL, Reichardt SD, Reichardt HM, G?rtner J, Bartolomei MS, Fang M, Loeb K, Keene CD, Bernstein I, Goodell M, Brat DJ, Huppke P, Neul JL, Bedalov A, Pieper AANatureWild-type microglia do not reverse pathology in mouse models of Rett syndrome. Nature. 2015 May 21; 521(7552):E1-4.Nature2015-05-21T00:00:002015Wild-type microglia do not reverse pathology in mouse models of Rett syndrome.Authorship 628684Authorship 743166Authorship 798686Authorship 877286Authorship 939223Center for Cell & Gene TherapyAYALATOVYAYALA TOVY10354TOVY, AYALAAdjunct Assistant ProfessorAuthorship 29572933Authorship 2965995Authorship 3014935Authorship 3031401Authorship 3041744Authorship 305863826072330King KY, Matatall KA, Shen CC, Goodell MA, Swierczek SI, Prchal JTExperimental hematologyComparative long-term effects of interferon a and hydroxyurea on human hematopoietic progenitor cells. Exp Hematol. 2015 Oct; 43(10):912-918.e2.Exp Hematol2015-06-11T00:00:002015Comparative long-term effects of interferon a and hydroxyurea on human hematopoietic progenitor cells.26141441Gibson BW, Boles NC, Souroullas GP, Herron AJ, Fraley JK, Schwiebert RS, Sharp JJ, Goodell MAComparative medicineComparison of Cesium-137 and X-ray Irradiators by Using Bone Marrow Transplant Reconstitution in C57BL/6J Mice. Comp Med. 2015 Jun; 65(3):165-72.Comp Med2015-06-01T00:00:002015Comparison of Cesium-137 and X-ray Irradiators by Using Bone Marrow Transplant Reconstitution in C57BL/6J Mice.26176914Wang J, Wegener JE, Huang TW, Sripathy S, De Jesus-Cortes H, Xu P, Tran S, Knobbe W, Leko V, Britt J, Starwalt R, McDaniel L, Ward CS, Parra D, Newcomb B, Lao U, Nourigat C, Flowers DA, Cullen S, Jorstad NL, Yang Y, Glaskova L, Vigneau S, Kozlitina J, Yetman MJ, Jankowsky JL, Reichardt SD, Reichardt HM, G?rtner J, Bartolomei MS, Fang M, Loeb K, Keene CD, Bernstein I, Goodell M, Brat DJ, Huppke P, Neul JL, Bedalov A, Pieper AANatureCorrigendum: Wild-type microglia do not reverse pathology in mouse models of Rett syndrome. Nature. 2015 Sep 24; 525(7570):552.Nature2015-07-15T00:00:002015Corrigendum: Wild-type microglia do not reverse pathology in mouse models of Rett syndrome.26247067Artandi SE, Blau HM, de Haan G, Geiger H, Goodell MA, Jones L, Levine RL, Mu?oz-C?noves P, Rodewald HR, Wagers A, Wang ZQ, Yamashita YCell stem cellStem Cells and Aging: What's Next? Cell Stem Cell. 2015 Jun 04; 16(6):578-81.Cell Stem Cell2015-06-04T00:00:002015Stem Cells and Aging: What's Next?26607761An J, Gonz?lez-Avalos E, Chawla A, Jeong M, L?pez-Moyado IF, Li W, Goodell MA, Chavez L, Ko M, Rao ANature communicationsAcute loss of TET function results in aggressive myeloid cancer in mice. Nat Commun. 2015 Nov 26; 6:10071.Nat Commun2015-11-26T00:00:002015Acute loss of TET function results in aggressive myeloid cancer in mice.26785478Goodell MA, Rando TAScience (New York, N.Y.)Stem cells and healthy aging. Science. 2015 Dec 04; 350(6265):1199-204.Science2015-12-04T00:00:002015Stem cells and healthy aging.15122901Qyang Y, Chambers SM, Wang P, Xia X, Chen X, Goodell MA, Zheng HBiochemistryMyeloproliferative disease in mice with reduced presenilin gene dosage: effect of gamma-secretase blockage. Biochemistry. 2004 May 11; 43(18):5352-9.Biochemistry2004-05-11T00:00:002004Myeloproliferative disease in mice with reduced presenilin gene dosage: effect of gamma-secretase blockage.27300438Yang L, Rodriguez B, Mayle A, Park HJ, Lin X, Luo M, Jeong M, Curry CV, Kim SB, Ruau D, Zhang X, Zhou T, Zhou M, Rebel VI, Challen GA, Gottgens B, Lee JS, Rau R, Li W, Goodell MACancer cellDNMT3A Loss Drives Enhancer Hypomethylation in FLT3-ITD-Associated Leukemias. Cancer Cell. 2016 06 13; 29(6):922-934.Cancer Cell2016-06-13T00:00:002016DNMT3A Loss Drives Enhancer Hypomethylation in FLT3-ITD-Associated Leukemias.27208809Eckstein OS, Wang L, Punia JN, Kornblau SM, Andreeff M, Wheeler DA, Goodell MA, Rau REExperimental hematologyMixed-phenotype acute leukemia (MPAL) exhibits frequent mutations in DNMT3A and activated signaling genes. Exp Hematol. 2016 08; 44(8):740-4.Exp Hematol2016-05-18T00:00:002016Mixed-phenotype acute leukemia (MPAL) exhibits frequent mutations in DNMT3A and activated signaling genes.12135680Heinz M, Huang CA, Emery DW, Giovino MA, LeGuern A, Kurilla-Mahon B, Theodore P, Arn JS, Sykes M, Mulligan R, Down JD, Sachs DH, Goodell MAExperimental hematologyUse of CD9 expression to enrich for porcine hematopoietic progenitors. Exp Hematol. 2002 Jul; 30(7):809-15.Exp Hematol2002-07-01T00:00:002002Use of CD9 expression to enrich for porcine hematopoietic progenitors.15625117Civin CI, Gewirtz AM, Hawley RG, Goodell MAStem cells (Dayton, Ohio)Advancing the fast-paced field of stem cell research: stem cells increases from 6 to 10 issues in its 23rd year of publication. Stem Cells. 2005; 23(1):1-2.Stem Cells2005-01-01T00:00:002005Advancing the fast-paced field of stem cell research: stem cells increases from 6 to 10 issues in its 23rd year of publication.74Professor10Assistant Professor21Chair14Associate Professor2Adjunct Assistant Professor3Adjunct Associate Professor27335278Rau RE, Rodriguez BA, Luo M, Jeong M, Rosen A, Rogers JH, Campbell CT, Daigle SR, Deng L, Song Y, Sweet S, Chevassut T, Andreeff M, Kornblau SM, Li W, Goodell MABloodDOT1L as a therapeutic target for the treatment of DNMT3A-mutant acute myeloid leukemia. Blood. 2016 08 18; 128(7):971-81.Blood2016-06-22T00:00:002016DOT1L as a therapeutic target for the treatment of DNMT3A-mutant acute myeloid leukemia.KOICHITAKAHASHIKOICHI TAKAHASHI11823TAKAHASHI, KOICHIAssistant Professor12511590Majka SM, Jackson KA, Kienstra KA, Majesky MW, Goodell MA, Hirschi KKThe Journal of clinical investigationDistinct progenitor populations in skeletal muscle are bone marrow derived and exhibit different cell fates during vascular regeneration. J Clin Invest. 2003 Jan; 111(1):71-9.J Clin Invest2003-01-01T00:00:002003Distinct progenitor populations in skeletal muscle are bone marrow derived and exhibit different cell fates during vascular regeneration.One Baylor PlazaHouston, 77030TX12929091Oliveira DM, Goodell MAGenesis (New York, N.Y. : 2000)Transient RNA interference in hematopoietic progenitors with functional consequences. Genesis. 2003 Aug; 36(4):203-8.Genesis2003-08-01T00:00:002003Transient RNA interference in hematopoietic progenitors with functional consequences.Authorship 32293820Authorship 32481516Authorship 325156717032926Dumble M, Moore L, Chambers SM, Geiger H, Van Zant G, Goodell MA, Donehower LABloodThe impact of altered p53 dosage on hematopoietic stem cell dynamics during aging. Blood. 2007 Feb 15; 109(4):1736-42.Blood2006-10-10T00:00:002006The impact of altered p53 dosage on hematopoietic stem cell dynamics during aging.14625546Camargo FD, Green R, Capetanaki Y, Jackson KA, Goodell MA, Capetenaki YNature medicineSingle hematopoietic stem cells generate skeletal muscle through myeloid intermediates. Nat Med. 2003 Dec; 9(12):1520-7.Nat Med2003-11-16T00:00:002003Single hematopoietic stem cells generate skeletal muscle through myeloid intermediates.Authorship 3263411227428748Zhang X, Su J, Jeong M, Ko M, Huang Y, Park HJ, Guzman A, Lei Y, Huang YH, Rao A, Li W, Goodell MANature geneticsDNMT3A and TET2 compete and cooperate to repress lineage-specific transcription factors in hematopoietic stem cells. Nat Genet. 2016 09; 48(9):1014-23.Nat Genet2016-07-18T00:00:002016DNMT3A and TET2 compete and cooperate to repress lineage-specific transcription factors in hematopoietic stem cells.12545553Ramos CA, Zheng Y, Colombowala I, Goodell MABioTechniquesTracing the origin of non-hematopoietic cells using CD45 PCR restriction fragment length polymorphisms. Biotechniques. 2003 Jan; 34(1):160-2.Biotechniques2003-01-01T00:00:002003Tracing the origin of non-hematopoietic cells using CD45 PCR restriction fragment length polymorphisms.Authorship 326920727582470Karlstaedt A, Zhang X, Vitrac H, Harmancey R, Vasquez H, Wang JH, Goodell MA, Taegtmeyer HProceedings of the National Academy of Sciences of the United States of AmericaOncometabolite d-2-hydroxyglutarate impairs a-ketoglutarate dehydrogenase and contractile function in rodent heart. Proc Natl Acad Sci U S A. 2016 09 13; 113(37):10436-41.Proc Natl Acad Sci U S A2016-08-31T00:00:002016Oncometabolite d-2-hydroxyglutarate impairs a-ketoglutarate dehydrogenase and contractile function in rodent heart.12661162Ramos CA, Venezia TA, Camargo FA, Goodell MABioTechniquesTechniques for the study of adult stem cells: be fruitful and multiply. Biotechniques. 2003 Mar; 34(3):572-8, 580-4, 586-91.Biotechniques2003-03-01T00:00:002003Techniques for the study of adult stem cells: be fruitful and multiply.12668129Bradfute SB, Goodell MAMolecular therapy : the journal of the American Society of Gene TherapyAdenoviral transduction of mouse hematopoietic stem cells. Mol Ther. 2003 Mar; 7(3):334-40.Mol Ther2003-03-01T00:00:002003Adenoviral transduction of mouse hematopoietic stem cells.12681963Wulf GG, Luo KL, Jackson KA, Brenner MK, Goodell MAHaematologicaCells of the hepatic side population contribute to liver regeneration and can be replenished with bone marrow stem cells. Haematologica. 2003 Apr; 88(4):368-78.Haematologica2003-04-01T00:00:002003Cells of the hepatic side population contribute to liver regeneration and can be replenished with bone marrow stem cells.17949891Yankelevich M, Goodell MA, Kaplan JExperimental hematologyEfficacy of delayed administration of post-chemotherapy granulocyte colony-stimulating factor: evidence from murine studies of bone marrow cell kinetics. Exp Hematol. 2008 Jan; 36(1):9-16.Exp Hematol2007-10-18T00:00:002007Efficacy of delayed administration of post-chemotherapy granulocyte colony-stimulating factor: evidence from murine studies of bone marrow cell kinetics.18371424Feng CG, Weksberg DC, Taylor GA, Sher A, Goodell MACell stem cellThe p47 GTPase Lrg-47 (Irgm1) links host defense and hematopoietic stem cell proliferation. Cell Stem Cell. 2008 Jan 10; 2(1):83-9.Cell Stem Cell2008-01-10T00:00:002008The p47 GTPase Lrg-47 (Irgm1) links host defense and hematopoietic stem cell proliferation.19113897Vieyra DS, Rosen A, Goodell MAStem cells and developmentIdentification and characterization of side population cells in embryonic stem cell cultures. Stem Cells Dev. 2009 Oct; 18(8):1155-66.Stem Cells Dev2009-10-01T00:00:002009Identification and characterization of side population cells in embryonic stem cell cultures.19200805Souroullas GP, Salmon JM, Sablitzky F, Curtis DJ, Goodell MACell stem cellAdult hematopoietic stem and progenitor cells require either Lyl1 or Scl for survival. Cell Stem Cell. 2009 Feb 06; 4(2):180-6.Cell Stem Cell2009-02-06T00:00:002009Adult hematopoietic stem and progenitor cells require either Lyl1 or Scl for survival.14673088Olmsted-Davis EA, Gugala Z, Camargo F, Gannon FH, Jackson K, Kienstra KA, Shine HD, Lindsey RW, Hirschi KK, Goodell MA, Brenner MK, Davis ARProceedings of the National Academy of Sciences of the United States of AmericaPrimitive adult hematopoietic stem cells can function as osteoblast precursors. Proc Natl Acad Sci U S A. 2003 Dec 23; 100(26):15877-82.Proc Natl Acad Sci U S A2003-12-12T00:00:002003Primitive adult hematopoietic stem cells can function as osteoblast precursors.14990857Jackson KA, Snyder DS, Goodell MAStem cells (Dayton, Ohio)Skeletal muscle fiber-specific green autofluorescence: potential for stem cell engraftment artifacts. Stem Cells. 2004; 22(2):180-7.Stem Cells2004-01-01T00:00:002004Skeletal muscle fiber-specific green autofluorescence: potential for stem cell engraftment artifacts.20034552Ergen AV, Goodell MAExperimental gerontologyMechanisms of hematopoietic stem cell aging. Exp Gerontol. 2010 Apr; 45(4):286-90.Exp Gerontol2009-12-23T00:00:002009Mechanisms of hematopoietic stem cell aging.20207229Challen GA, Boles NC, Chambers SM, Goodell MACell stem cellDistinct hematopoietic stem cell subtypes are differentially regulated by TGF-beta1. Cell Stem Cell. 2010 Mar 05; 6(3):265-78.Cell Stem Cell2010-03-05T00:00:002010Distinct hematopoietic stem cell subtypes are differentially regulated by TGF-beta1.15459755Venezia TA, Merchant AA, Ramos CA, Whitehouse NL, Young AS, Shaw CA, Goodell MAPLoS biologyMolecular signatures of proliferation and quiescence in hematopoietic stem cells. PLoS Biol. 2004 Oct; 2(10):e301.PLoS Biol2004-09-28T00:00:002004Molecular signatures of proliferation and quiescence in hematopoietic stem cells.21387538Souroullas GP, Goodell MAGenesis (New York, N.Y. : 2000)A new allele of Lyl1 confirms its important role in hematopoietic stem cell function. Genesis. 2011 Jun; 49(6):441-8.Genesis2011-05-31T00:00:002011A new allele of Lyl1 confirms its important role in hematopoietic stem cell function.21576698Boles NC, Lin KK, Lukov GL, Bowman TV, Baldridge MT, Goodell MABloodCD48 on hematopoietic progenitors regulates stem cells and suppresses tumor formation. Blood. 2011 Jul 07; 118(1):80-7.Blood2011-05-16T00:00:002011CD48 on hematopoietic progenitors regulates stem cells and suppresses tumor formation.16582451Civin CI, Gewirtz AM, Goodell MA, Hawley RG, Murphy MJStem cells (Dayton, Ohio)Editorial retraction. Stem Cells. 2006 Apr; 24(4):804.Stem Cells2006-04-02T00:00:002006Editorial retraction.21904387King KY, Goodell MANature reviews. ImmunologyInflammatory modulation of HSCs: viewing the HSC as a foundation for the immune response. Nat Rev Immunol. 2011 Sep 09; 11(10):685-92.Nat Rev Immunol2011-09-09T00:00:002011Inflammatory modulation of HSCs: viewing the HSC as a foundation for the immune response.21964307Challen GA, Goodell MAMolecular therapy : the journal of the American Society of Gene TherapyBridge over troubled stem cells. Mol Ther. 2011 Oct; 19(10):1756-8.Mol Ther2011-10-01T00:00:002011Bridge over troubled stem cells.17119121Kustikova OS, Geiger H, Li Z, Brugman MH, Chambers SM, Shaw CA, Pike-Overzet K, de Ridder D, Staal FJ, von Keudell G, Cornils K, Nattamai KJ, Modlich U, Wagemaker G, Goodell MA, Fehse B, Baum CBloodRetroviral vector insertion sites associated with dominant hematopoietic clones mark "stemness" pathways. Blood. 2007 Mar 01; 109(5):1897-907.Blood2006-11-21T00:00:002006Retroviral vector insertion sites associated with dominant hematopoietic clones mark "stemness" pathways.17132877Vieyra DS, Jackson KA, Goodell MAStem cell reviewsPlasticity and tissue regenerative potential of bone marrow-derived cells. Stem Cell Rev. 2005; 1(1):65-9.Stem Cell Rev2005-01-01T00:00:002005Plasticity and tissue regenerative potential of bone marrow-derived cells.17676974Chambers SM, Shaw CA, Gatza C, Fisk CJ, Donehower LA, Goodell MAPLoS biologyAging hematopoietic stem cells decline in function and exhibit epigenetic dysregulation. PLoS Biol. 2007 Aug; 5(8):e201.PLoS Biol2007-08-01T00:00:002007Aging hematopoietic stem cells decline in function and exhibit epigenetic dysregulation.17161700Lin KK, Goodell MAMethods in enzymologyPurification of hematopoietic stem cells using the side population. Methods Enzymol. 2006; 420:255-64.Methods Enzymol2006-01-01T00:00:002006Purification of hematopoietic stem cells using the side population.18055867Weksberg DC, Chambers SM, Boles NC, Goodell MABloodCD150- side population cells represent a functionally distinct population of long-term hematopoietic stem cells. Blood. 2008 Feb 15; 111(4):2444-51.Blood2007-11-30T00:00:002007CD150- side population cells represent a functionally distinct population of long-term hematopoietic stem cells.17628023Vieyra DS, Goodell MAStem cells (Dayton, Ohio)Pluripotentiality and conditional transgene regulation in human embryonic stem cells expressing insulated tetracycline-ON transactivator. Stem Cells. 2007 Oct; 25(10):2559-66.Stem Cells2007-07-12T00:00:002007Pluripotentiality and conditional transgene regulation in human embryonic stem cells expressing insulated tetracycline-ON transactivator.17666739Bowman TV, Merchant AA, Goodell MAMethods in molecular medicineMolecular profiling of hematopoietic stem cells. Methods Mol Med. 2007; 134:1-16.Methods Mol Med2007-01-01T00:00:002007Molecular profiling of hematopoietic stem cells.18371372Berg JS, Goodell MACell stem cellAn argument against a role for Oct4 in somatic stem cells. Cell Stem Cell. 2007 Oct 11; 1(4):359-60.Cell Stem Cell2007-10-11T00:00:002007An argument against a role for Oct4 in somatic stem cells.18523660Challen GA, Goodell MAPloS onePromiscuous expression of H2B-GFP transgene in hematopoietic stem cells. PLoS One. 2008 Jun 04; 3(6):e2357.PLoS One2008-06-04T00:00:002008Promiscuous expression of H2B-GFP transgene in hematopoietic stem cells.19023891Challen GA, Boles N, Lin KK, Goodell MACytometry. Part A : the journal of the International Society for Analytical CytologyMouse hematopoietic stem cell identification and analysis. Cytometry A. 2009 Jan; 75(1):14-24.Cytometry A2009-01-01T00:00:002009Mouse hematopoietic stem cell identification and analysis.Authorship 654306328003281Brunetti L, Gundry MC, Goodell MACold Spring Harbor perspectives in medicineDNMT3A in Leukemia. Cold Spring Harb Perspect Med. 2017 Feb 01; 7(2).Cold Spring Harb Perspect Med2017-02-01T00:00:002017DNMT3A in Leukemia.19922650Foster AE, Okur FV, Biagi E, Lu A, Dotti G, Yvon E, Savoldo B, Carrum G, Andreeff M, Goodell MA, Heslop HE, Brenner MKMolecular cancerSelective depletion of a minor subpopulation of B-chronic lymphocytic leukemia cells is followed by a delayed but progressive loss of bulk tumor cells and disease regression. Mol Cancer. 2009 Nov 18; 8:106.Mol Cancer2009-11-18T00:00:002009Selective depletion of a minor subpopulation of B-chronic lymphocytic leukemia cells is followed by a delayed but progressive loss of bulk tumor cells and disease regression.20052416Boles NC, Peddibhotla S, Chen AJ, Goodell MA, Rosen JMPloS oneChk1 haploinsufficiency results in anemia and defective erythropoiesis. PLoS One. 2010 Jan 05; 5(1):e8581.PLoS One2010-01-05T00:00:002010Chk1 haploinsufficiency results in anemia and defective erythropoiesis.20206228Challen GA, Goodell MAExperimental hematologyRunx1 isoforms show differential expression patterns during hematopoietic development but have similar functional effects in adult hematopoietic stem cells. Exp Hematol. 2010 May; 38(5):403-16.Exp Hematol2010-03-03T00:00:002010Runx1 isoforms show differential expression patterns during hematopoietic development but have similar functional effects in adult hematopoietic stem cells.27783956Gundry MC, Brunetti L, Lin A, Mayle AE, Kitano A, Wagner D, Hsu JI, Hoegenauer KA, Rooney CM, Goodell MA, Nakada DCell reportsHighly Efficient Genome Editing of Murine and Human Hematopoietic Progenitor Cells by CRISPR/Cas9. Cell Rep. 2016 10 25; 17(5):1453-1461.Cell Rep2016-10-25T00:00:002016Highly Efficient Genome Editing of Murine and Human Hematopoietic Progenitor Cells by CRISPR/Cas9.20535209Baldridge MT, King KY, Boles NC, Weksberg DC, Goodell MANatureQuiescent haematopoietic stem cells are activated by IFN-gamma in response to chronic infection. Nature. 2010 Jun 10; 465(7299):793-7.Nature2010-06-10T00:00:002010Quiescent haematopoietic stem cells are activated by IFN-gamma in response to chronic infection.21233016Baldridge MT, King KY, Goodell MATrends in immunologyInflammatory signals regulate hematopoietic stem cells. Trends Immunol. 2011 Feb; 32(2):57-65.Trends Immunol2011-01-11T00:00:002011Inflammatory signals regulate hematopoietic stem cells.21283700King KY, Lew JD, Ha NP, Lin JS, Ma X, Graviss EA, Goodell MAPloS onePolymorphic allele of human IRGM1 is associated with susceptibility to tuberculosis in African Americans. PLoS One. 2011 Jan 21; 6(1):e16317.PLoS One2011-01-21T00:00:002011Polymorphic allele of human IRGM1 is associated with susceptibility to tuberculosis in African Americans.21495066Liao J, Hammerick KE, Challen GA, Goodell MA, Kasper FK, Mikos AGJournal of orthopaedic research : official publication of the Orthopaedic Research SocietyInvestigating the role of hematopoietic stem and progenitor cells in regulating the osteogenic differentiation of mesenchymal stem cells in vitro. J Orthop Res. 2011 Oct; 29(10):1544-53.J Orthop Res2011-04-14T00:00:002011Investigating the role of hematopoietic stem and progenitor cells in regulating the osteogenic differentiation of mesenchymal stem cells in vitro.21521782Rossi L, Ergen AV, Goodell MABloodTIMP-1 deficiency subverts cell-cycle dynamics in murine long-term HSCs. Blood. 2011 Jun 16; 117(24):6479-88.Blood2011-04-26T00:00:002011TIMP-1 deficiency subverts cell-cycle dynamics in murine long-term HSCs.20705338Lukov GL, Rossi L, Souroullas GP, Mao R, Goodell MALeukemia researchThe expansion of T-cells and hematopoietic progenitors as a result of overexpression of the lymphoblastic leukemia gene, Lyl1 can support leukemia formation. Leuk Res. 2011 Mar; 35(3):405-12.Leuk Res2010-08-11T00:00:002010The expansion of T-cells and hematopoietic progenitors as a result of overexpression of the lymphoblastic leukemia gene, Lyl1 can support leukemia formation.20844761Lukov GL, Goodell MAPloS oneLYL1 degradation by the proteasome is directed by a N-terminal PEST rich site in a phosphorylation-independent manner. PLoS One. 2010 Sep 10; 5(9).PLoS One2010-09-10T00:00:002010LYL1 degradation by the proteasome is directed by a N-terminal PEST rich site in a phosphorylation-independent manner.22039481Berg JS, Lin KK, Sonnet C, Boles NC, Weksberg DC, Nguyen H, Holt LJ, Rickwood D, Daly RJ, Goodell MAPloS oneImprinted genes that regulate early mammalian growth are coexpressed in somatic stem cells. PLoS One. 2011; 6(10):e26410.PLoS One2011-10-19T00:00:002011Imprinted genes that regulate early mammalian growth are coexpressed in somatic stem cells.22138693Challen GA, Sun D, Jeong M, Luo M, Jelinek J, Berg JS, Bock C, Vasanthakumar A, Gu H, Xi Y, Liang S, Lu Y, Darlington GJ, Meissner A, Issa JP, Godley LA, Li W, Goodell MANature geneticsDnmt3a is essential for hematopoietic stem cell differentiation. Nat Genet. 2011 Dec 04; 44(1):23-31.Nat Genet2011-12-04T00:00:002011Dnmt3a is essential for hematopoietic stem cell differentiation.21076412Sirin O, Lukov GL, Mao R, Conneely OM, Goodell MANature cell biologyThe orphan nuclear receptor Nurr1 restricts the proliferation of haematopoietic stem cells. Nat Cell Biol. 2010 Dec; 12(12):1213-9.Nat Cell Biol2010-11-14T00:00:002010The orphan nuclear receptor Nurr1 restricts the proliferation of haematopoietic stem cells.22289892Ergen AV, Boles NC, Goodell MABloodRantes/Ccl5 influences hematopoietic stem cell subtypes and causes myeloid skewing. Blood. 2012 Mar 15; 119(11):2500-9.Blood2012-01-30T00:00:002012Rantes/Ccl5 influences hematopoietic stem cell subtypes and causes myeloid skewing.21289635King KY, Goodell MAMolecular therapy : the journal of the American Society of Gene TherapyDirect conversion of skin cells into blood: alchemy or science? Mol Ther. 2011 Feb; 19(2):227-8.Mol Ther2011-02-01T00:00:002011Direct conversion of skin cells into blood: alchemy or science?22576171James RA, Rao MM, Chen ES, Goodell MA, Shaw CABioinformatics (Oxford, England)The Hematopoietic Expression Viewer: expanding mobile apps as a scientific tool. Bioinformatics. 2012 Jul 15; 28(14):1941-2.Bioinformatics2012-05-09T00:00:002012The Hematopoietic Expression Viewer: expanding mobile apps as a scientific tool.22615578Li J, Harris RA, Cheung SW, Coarfa C, Jeong M, Goodell MA, White LD, Patel A, Kang SH, Shaw C, Chinault AC, Gambin T, Gambin A, Lupski JR, Milosavljevic APLoS geneticsGenomic hypomethylation in the human germline associates with selective structural mutability in the human genome. PLoS Genet. 2012; 8(5):e1002692.PLoS Genet2012-05-17T00:00:002012Genomic hypomethylation in the human germline associates with selective structural mutability in the human genome.Authorship 78515119Authorship 785192927505680Yang L, Rodriguez B, Mayle A, Park HJ, Lin X, Luo M, Jeong M, Curry CV, Kim SB, Ruau D, Zhang X, Zhou T, Zhou M, Rebel VI, Challen GA, G?ttgens B, Lee JS, Rau R, Li W, Goodell MACancer cellDNMT3A Loss Drives Enhancer Hypomethylation in FLT3-ITD-Associated Leukemias. Cancer Cell. 2016 08 08; 30(2):363-365.Cancer Cell2016-08-08T00:00:002016DNMT3A Loss Drives Enhancer Hypomethylation in FLT3-ITD-Associated Leukemias.22958929Rossi L, Lin KK, Boles NC, Yang L, King KY, Jeong M, Mayle A, Goodell MACell stem cellLess is more: unveiling the functional core of hematopoietic stem cells through knockout mice. Cell Stem Cell. 2012 Sep 07; 11(3):302-17.Cell Stem Cell2012-09-07T00:00:002012Less is more: unveiling the functional core of hematopoietic stem cells through knockout mice.23022127Rossi L, Lemoli RM, Goodell MAExperimental hematologyGpr171, a putative P2Y-like receptor, negatively regulates myeloid differentiation in murine hematopoietic progenitors. Exp Hematol. 2013 Jan; 41(1):102-12.Exp Hematol2012-09-25T00:00:002012Gpr171, a putative P2Y-like receptor, negatively regulates myeloid differentiation in murine hematopoietic progenitors.21618082Rossi L, Challen GA, Sirin O, Lin KK, Goodell MAMethods in molecular biology (Clifton, N.J.)Hematopoietic stem cell characterization and isolation. Methods Mol Biol. 2011; 750:47-59.Methods Mol Biol2011-01-01T00:00:002011Hematopoietic stem cell characterization and isolation.Authorship 875408928695892Lei Y, Zhang X, Su J, Jeong M, Gundry MC, Huang YH, Zhou Y, Li W, Goodell MANature communicationsTargeted DNA methylation in vivo using an engineered dCas9-MQ1 fusion protein. Nat Commun. 2017 07 11; 8:16026.Nat Commun2017-07-11T00:00:002017Targeted DNA methylation in vivo using an engineered dCas9-MQ1 fusion protein.12799286Brenner MK, Wulf GG, Rill DR, Luo KL, Goodell MA, Mei Z, Kuehnle I, Brown MP, Pule M, Heslop HE, Krance RAAnnals of the New York Academy of SciencesComplement-fixing CD45 monoclonal antibodies to facilitate stem cell transplantation in mouse and man. Ann N Y Acad Sci. 2003 May; 996:80-8.Ann N Y Acad Sci2003-05-01T00:00:002003Complement-fixing CD45 monoclonal antibodies to facilitate stem cell transplantation in mouse and man.12805065Nadin BM, Goodell MA, Hirschi KKBloodPhenotype and hematopoietic potential of side population cells throughout embryonic development. Blood. 2003 Oct 01; 102(7):2436-43.Blood2003-06-12T00:00:002003Phenotype and hematopoietic potential of side population cells throughout embryonic development.12962727McKinney-Freeman SL, Majka SM, Jackson KA, Norwood K, Hirschi KK, Goodell MAExperimental hematologyAltered phenotype and reduced function of muscle-derived hematopoietic stem cells. Exp Hematol. 2003 Sep; 31(9):806-14.Exp Hematol2003-09-01T00:00:002003Altered phenotype and reduced function of muscle-derived hematopoietic stem cells.14521513Welm B, Behbod F, Goodell MA, Rosen JMCell proliferationIsolation and characterization of functional mammary gland stem cells. Cell Prolif. 2003 Oct; 36 Suppl 1:17-32.Cell Prolif2003-10-01T00:00:002003Isolation and characterization of functional mammary gland stem cells.14633792Daley GQ, Goodell MA, Snyder EYHematology. American Society of Hematology. Education ProgramRealistic prospects for stem cell therapeutics. Hematology Am Soc Hematol Educ Program. 2003; 398-418.Hematology Am Soc Hematol Educ Program2003-01-01T00:00:002003Realistic prospects for stem cell therapeutics.14687625Norwood K, Wang RY, Hirschmann-Jax C, Andreeff M, Brenner MK, Goodell MA, Wulf GGLeukemia researchAn in vivo propagated human acute myeloid leukemia expressing ABCA3. Leuk Res. 2004 Mar; 28(3):295-9.Leuk Res2004-03-01T00:00:002004An in vivo propagated human acute myeloid leukemia expressing ABCA3.15048913Snyder EY, Daley GQ, Goodell MJournal of neuroscience researchTaking stock and planning for the next decade: realistic prospects for stem cell therapies for the nervous system. J Neurosci Res. 2004 Apr 15; 76(2):157-68.J Neurosci Res2004-04-15T00:00:002004Taking stock and planning for the next decade: realistic prospects for stem cell therapies for the nervous system.15124017Camargo FD, Finegold M, Goodell MAThe Journal of clinical investigationHematopoietic myelomonocytic cells are the major source of hepatocyte fusion partners. J Clin Invest. 2004 May; 113(9):1266-70.J Clin Invest2004-05-01T00:00:002004Hematopoietic myelomonocytic cells are the major source of hepatocyte fusion partners.15345289McKinney-Freeman S, Goodell MAExperimental hematologyCirculating hematopoietic stem cells do not efficiently home to bone marrow during homeostasis. Exp Hematol. 2004 Sep; 32(9):868-76.Exp Hematol2004-09-01T00:00:002004Circulating hematopoietic stem cells do not efficiently home to bone marrow during homeostasis.15361673Goodell MA, McKinney-Freeman S, Camargo FDMethods in molecular biology (Clifton, N.J.)Isolation and characterization of side population cells. Methods Mol Biol. 2005; 290:343-52.Methods Mol Biol2005-01-01T00:00:002005Isolation and characterization of side population cells.15963860Bradfute SB, Graubert TA, Goodell MAExperimental hematologyRoles of Sca-1 in hematopoietic stem/progenitor cell function. Exp Hematol. 2005 Jul; 33(7):836-43.Exp Hematol2005-07-01T00:00:002005Roles of Sca-1 in hematopoietic stem/progenitor cell function.Authorship 104922516204316Camargo FD, Chambers SM, Drew E, McNagny KM, Goodell MABloodHematopoietic stem cells do not engraft with absolute efficiencies. Blood. 2006 Jan 15; 107(2):501-7.Blood2005-10-04T00:00:002005Hematopoietic stem cells do not engraft with absolute efficiencies.16373690Bowman TV, McCooey AJ, Merchant AA, Ramos CA, Fonseca P, Poindexter A, Bradfute SB, Oliveira DM, Green R, Zheng Y, Jackson KA, Chambers SM, McKinney-Freeman SL, Norwood KG, Darlington G, Gunaratne PH, Steffen D, Goodell MAStem cells (Dayton, Ohio)Differential mRNA processing in hematopoietic stem cells. Stem Cells. 2006 Mar; 24(3):662-70.Stem Cells2005-12-22T00:00:002005Differential mRNA processing in hematopoietic stem cells.17009876Ramos CA, Bowman TA, Boles NC, Merchant AA, Zheng Y, Parra I, Fuqua SA, Shaw CA, Goodell MAPLoS geneticsEvidence for diversity in transcriptional profiles of single hematopoietic stem cells. PLoS Genet. 2006 Sep 29; 2(9):e159.PLoS Genet2006-08-09T00:00:002006Evidence for diversity in transcriptional profiles of single hematopoietic stem cells.17452146Jolicoeur EM, Granger CB, Fakunding JL, Mockrin SC, Grant SM, Ellis SG, Weisel RD, Goodell MA, National Heart, Lung, and Blood Institute Cell Therapy Working Group MembersAmerican heart journalBringing cardiovascular cell-based therapy to clinical application: perspectives based on a National Heart, Lung, and Blood Institute Cell Therapy Working Group meeting. Am Heart J. 2007 May; 153(5):732-42.Am Heart J2007-05-01T00:00:002007Bringing cardiovascular cell-based therapy to clinical application: perspectives based on a National Heart, Lung, and Blood Institute Cell Therapy Working Group meeting.18371395Chambers SM, Boles NC, Lin KY, Tierney MP, Bowman TV, Bradfute SB, Chen AJ, Merchant AA, Sirin O, Weksberg DC, Merchant MG, Fisk CJ, Shaw CA, Goodell MACell stem cellHematopoietic fingerprints: an expression database of stem cells and their progeny. Cell Stem Cell. 2007 Nov; 1(5):578-91.Cell Stem Cell2007-11-01T00:00:002007Hematopoietic fingerprints: an expression database of stem cells and their progeny.Authorship 104253618770827Goodell MACurrent protocols in cytometryStem cell identification and sorting using the Hoechst 33342 side population (SP). Curr Protoc Cytom. 2005 Nov; Chapter 9:Unit9.18.Curr Protoc Cytom2005-11-01T00:00:002005Stem cell identification and sorting using the Hoechst 33342 side population (SP).20025523Sharabi AB, Lee SH, Goodell MA, Huang XF, Chen SYCloning and stem cellsEnhanced generation of myeloid lineages in hematopoietic differentiation from embryonic stem cells by silencing transcriptional repressor Twist-2. Cloning Stem Cells. 2009 Dec; 11(4):523-33.Cloning Stem Cells2009-12-01T00:00:002009Enhanced generation of myeloid lineages in hematopoietic differentiation from embryonic stem cells by silencing transcriptional repressor Twist-2.21633090King KY, Baldridge MT, Weksberg DC, Chambers SM, Lukov GL, Wu S, Boles NC, Jung SY, Qin J, Liu D, Songyang Z, Eissa NT, Taylor GA, Goodell MABloodIrgm1 protects hematopoietic stem cells by negative regulation of IFN signaling. Blood. 2011 Aug 11; 118(6):1525-33.Blood2011-06-01T00:00:002011Irgm1 protects hematopoietic stem cells by negative regulation of IFN signaling.21931533Lin KK, Rossi L, Boles NC, Hall BE, George TC, Goodell MAPLoS biologyCD81 is essential for the re-entry of hematopoietic stem cells to quiescence following stress-induced proliferation via deactivation of the Akt pathway. PLoS Biol. 2011 Sep; 9(9):e1001148.PLoS Biol2011-09-13T00:00:002011CD81 is essential for the re-entry of hematopoietic stem cells to quiescence following stress-induced proliferation via deactivation of the Akt pathway.22736515Mayle A, Luo M, Jeong M, Goodell MACytometry. Part A : the journal of the International Society for Analytical CytologyFlow cytometry analysis of murine hematopoietic stem cells. Cytometry A. 2013 Jan; 83(1):27-37.Cytometry A2012-06-26T00:00:002012Flow cytometry analysis of murine hematopoietic stem cells.22772404Zohren F, Souroullas GP, Luo M, Gerdemann U, Imperato MR, Wilson NK, G?ttgens B, Lukov GL, Goodell MANature immunologyThe transcription factor Lyl-1 regulates lymphoid specification and the maintenance of early T lineage progenitors. Nat Immunol. 2012 Jul 08; 13(8):761-9.Nat Immunol2012-07-08T00:00:002012The transcription factor Lyl-1 regulates lymphoid specification and the maintenance of early T lineage progenitors.23179831Ergen AV, Jeong M, Lin KK, Challen GA, Goodell MAMethods in molecular biology (Clifton, N.J.)Isolation and characterization of mouse side population cells. Methods Mol Biol. 2013; 946:151-62.Methods Mol Biol2013-01-01T00:00:002013Isolation and characterization of mouse side population cells.Authorship 8811309Authorship 8818268Authorship 8822925Authorship 8829341328923089Huang YH, Su J, Lei Y, Brunetti L, Gundry MC, Zhang X, Jeong M, Li W, Goodell MAGenome biologyDNA epigenome editing using CRISPR-Cas SunTag-directed DNMT3A. Genome Biol. 2017 09 18; 18(1):176.Genome Biol2017-09-18T00:00:002017DNA epigenome editing using CRISPR-Cas SunTag-directed DNMT3A.29382756Tan Q, Brunetti L, Rousseaux MWC, Lu HC, Wan YW, Revelli JP, Liu Z, Goodell MA, Zoghbi HYProceedings of the National Academy of Sciences of the United States of AmericaLoss of Capicua alters early T cell development and predisposes mice to T cell lymphoblastic leukemia/lymphoma. Proc Natl Acad Sci U S A. 2018 02 13; 115(7):E1511-E1519.Proc Natl Acad Sci U S A2018-01-30T00:00:002018Loss of Capicua alters early T cell development and predisposes mice to T cell lymphoblastic leukemia/lymphoma.29617651Jeong M, Park HJ, Celik H, Ostrander EL, Reyes JM, Guzman A, Rodriguez B, Lei Y, Lee Y, Ding L, Guryanova OA, Li W, Goodell MA, Challen GACell reportsLoss of Dnmt3a Immortalizes Hematopoietic Stem Cells In?Vivo. Cell Rep. 2018 04 03; 23(1):1-10.Cell Rep2018-04-03T00:00:002018Loss of Dnmt3a Immortalizes Hematopoietic Stem Cells In?Vivo.29708546Brunetti L, Gundry MC, Kitano A, Nakada D, Goodell MAJournal of visualized experiments : JoVEHighly Efficient Gene Disruption of Murine and Human Hematopoietic Progenitor Cells by CRISPR/Cas9. J Vis Exp. 2018 04 10; (134).J Vis Exp2018-04-10T00:00:002018Highly Efficient Gene Disruption of Murine and Human Hematopoietic Progenitor Cells by CRISPR/Cas9.23555280Kahle JJ, Souroullas GP, Yu P, Zohren F, Lee Y, Shaw CA, Zoghbi HY, Goodell MAPLoS geneticsAtaxin1L is a regulator of HSC function highlighting the utility of cross-tissue comparisons for gene discovery. PLoS Genet. 2013 Mar; 9(3):e1003359.PLoS Genet2013-03-28T00:00:002013Ataxin1L is a regulator of HSC function highlighting the utility of cross-tissue comparisons for gene discovery.D006412Anatomy39312420.61997Hematopoietic Stem CellsD019175Physiology69726600.473619DNA MethylationAuthorship 1085578D004248Chemicals & Drugs1593110.805751DNA (Cytosine-5-)-MethyltransferasesD006410Physiology2255610.772164HematopoiesisD002454Physiology117240740.447983Cell DifferentiationAuthorship 9181143Authorship 93012511Authorship 93042817Authorship 9311549Authorship 9347013Authorship 93508220Authorship 93725220Authorship 9394744Authorship 939725328735485Jeong M, Guzman AG, Goodell MAMethods in molecular biology (Clifton, N.J.)Genome-Wide Analysis of DNA Methylation in Hematopoietic Cells: DNA Methylation Analysis by WGBS. Methods Mol Biol. 2017; 1633:137-149.Methods Mol Biol2017-01-01T00:00:002017Genome-Wide Analysis of DNA Methylation in Hematopoietic Cells: DNA Methylation Analysis by WGBS.30001199Gu T, Lin X, Cullen SM, Luo M, Jeong M, Estecio M, Shen J, Hardikar S, Sun D, Su J, Rux D, Guzman A, Lee M, Qi LS, Chen JJ, Kyba M, Huang Y, Chen T, Li W, Goodell MAGenome biologyDNMT3A and TET1 cooperate to regulate promoter epigenetic landscapes in mouse embryonic stem cells. Genome Biol. 2018 07 12; 19(1):88.Genome Biol2018-07-12T00:00:002018DNMT3A and TET1 cooperate to regulate promoter epigenetic landscapes in mouse embryonic stem cells.30205049Brunetti L, Gundry MC, Sorcini D, Guzman AG, Huang YH, Ramabadran R, Gionfriddo I, Mezzasoma F, Milano F, Nabet B, Buckley DL, Kornblau SM, Lin CY, Sportoletti P, Martelli MP, Falini B, Goodell MACancer cellMutant NPM1 Maintains the Leukemic State through HOX Expression. Cancer Cell. 2018 09 10; 34(3):499-512.e9.Cancer Cell2018-09-10T00:00:002018Mutant NPM1 Maintains the Leukemic State through HOX Expression.30400938Lei Y, Huang YH, Goodell MAGenome biologyDNA methylation and de-methylation using hybrid site-targeting proteins. Genome Biol. 2018 11 06; 19(1):187.Genome Biol2018-11-06T00:00:002018DNA methylation and de-methylation using hybrid site-targeting proteins.30097071Su J, Huang YH, Cui X, Wang X, Zhang X, Lei Y, Xu J, Lin X, Chen K, Lv J, Goodell MA, Li WGenome biologyHomeobox oncogene activation by pan-cancer DNA hypermethylation. Genome Biol. 2018 08 10; 19(1):108.Genome Biol2018-08-10T00:00:002018Homeobox oncogene activation by pan-cancer DNA hypermethylation.30644360Luo C, Lee QY, Wapinski O, Castanon R, Nery JR, Mall M, Kareta MS, Cullen SM, Goodell MA, Chang HY, Wernig M, Ecker JReLifeGlobal DNA methylation remodeling during direct reprogramming of fibroblasts to neurons. Elife. 2019 01 15; 8.Elife2019-01-15T00:00:002019Global DNA methylation remodeling during direct reprogramming of fibroblasts to neurons.30388424Hsu JI, Dayaram T, Tovy A, De Braekeleer E, Jeong M, Wang F, Zhang J, Heffernan TP, Gera S, Kovacs JJ, Marszalek JR, Bristow C, Yan Y, Garcia-Manero G, Kantarjian H, Vassiliou G, Futreal PA, Donehower LA, Takahashi K, Goodell MACell stem cellPPM1D Mutations Drive Clonal Hematopoiesis in Response to Cytotoxic Chemotherapy. Cell Stem Cell. 2018 11 01; 23(5):700-713.e6.Cell Stem Cell2018-11-01T00:00:002018PPM1D Mutations Drive Clonal Hematopoiesis in Response to Cytotoxic Chemotherapy.30632059Brunetti L, Gundry MC, Goodell MAInternational journal of hematologyNew insights into the biology of acute myeloid leukemia with mutated NPM1. Int J Hematol. 2019 Aug; 110(2):150-160.Int J Hematol2019-01-10T00:00:002019New insights into the biology of acute myeloid leukemia with mutated NPM1.30705090Sandoval JE, Huang YH, Muise A, Goodell MA, Reich NOThe Journal of biological chemistryMutations in the DNMT3A DNA methyltransferase in acute myeloid leukemia patients cause both loss and gain of function and differential regulation by protein partners. J Biol Chem. 2019 03 29; 294(13):4898-4910.J Biol Chem2019-01-31T00:00:002019Mutations in the DNMT3A DNA methyltransferase in acute myeloid leukemia patients cause both loss and gain of function and differential regulation by protein partners.2006-03-31NIHGOODELL, MARGARET2000-04-01CD34 NEGATIVE HUMAN HEMATOPOIETIC STEM CELLSR01CA0811792025-03-31NIHGOODELL, MARGARET A.2011-07-01REGULATION OF HEMATOPOIETIC PROGENITORS BY DE NOVO DNA METHYLATIONR01DK0928832006-01-31NIHGOODELL, MARGARET2005-02-01BD LSRII Four Laser Analytical Flow CytometerS10RR0210542010-08-31NIHGOODELL, MARGARET2005-09-30Safe and Efficient Generation of hES-derived Bone MarrowR01DK0753552001-03-31NIHGOODELL, MARGARET1999-04-01CD34NEGATIVE HUMAN HEMATOPOIETIC STEM CELLSR55CA0811792004-03-31NIHGOODELL, MARGARET2003-04-01ABI PRISM 7900 Sequence Detection SystemS10RR0178952014-08-31NIHGOODELL, MARGARET2007-09-01Regulatory Networks in Human Embryonic Stem CellsP01GM0816272011-07-31NIHGOODELL, MARGARET2009-08-15Cell Fate Tracking in the Aging Hematopoietic SystemR21AG0344512005-08-31NIHGOODELL, MARGARET2004-09-03Conference on Molecular Regulation of Stem CellsR13GM0733512024-08-31NIHGOODELL, MARGARET A.2014-09-11DNMT3A in Development of Hematologic MalignanciesR01CA1832522024-06-30NIHGOODELL, MARGARET A.2002-09-30Hematology Training ProgramT32DK0604452011-09-30NIHGOODELL, MARGARET2000-09-01Hematopoietic Stem Cell Differentiation and CommitmentR01DK0581922012-06-30NIHGOODELL, MARGARET2011-07-01Regulation of Hematopoietic Progenitors by de novo DNA MethylationR56DK092883Principal InvestigatorPrincipal InvestigatorPrincipal InvestigatorPrincipal InvestigatorPrincipal InvestigatorPrincipal InvestigatorPrincipal InvestigatorPrincipal InvestigatorPrincipal InvestigatorPrincipal InvestigatorPrincipal InvestigatorPrincipal InvestigatorPrincipal InvestigatorCenter for Cell & Gene TherapyDepartment of PediatricsDepartment of Molecular & Cellular BiologyDepartment of Molecular & Human GeneticsDepartment of Pathology & ImmunologyHuffington Center on AgingHuffington Ctr on AgingImmunologyMolecular & Cellular BiologyMolecular & Human GeneticsPediatrics-Hem/Onc Cell & Gene ThePediatrics-Infectious DiseasesPediatrics-OncologyBaylor College of MedicineALANDAVISALAN DAVIS18.5472050000000073.831670200000003621DAVIS, ALANAssociate ProfessorKATHERINEKINGKATHERINE KING0.000000000000000.00000000000000590KING, KATHERINE0000-0002-5093-6005Professor111groups15.06540.00421421592research areas3.54310.015310976coauthor of178.01336.4860similar to11163selected publicationsRACHELRAURACHEL RAU29.70508570000000-95.401808700000004434RAU, RACHELAdjunct Associate ProfessorAuthorship 943430130728147Goodell MA, Bodine DMBloodSingle-cell technology meets hematology: introduction to a review series. Blood. 2019 03 28; 133(13):1387-1388.Blood2019-02-06T00:00:002019Single-cell technology meets hematology: introduction to a review series.Authorship 944926230951659Rau RE, Goodell MACell stem cellMeasure Twice, Cut Once: Therapeutic Editing of HSPCs Requires Precise Planning. Cell Stem Cell. 2019 04 04; 24(4):511-512.Cell Stem Cell2019-04-04T00:00:002019Measure Twice, Cut Once: Therapeutic Editing of HSPCs Requires Precise Planning.Authorship 1263176Authorship 1284441Authorship 128978123692857Goodell MA, Godley LABloodPerspectives and future directions for epigenetics in hematology. Blood. 2013 Jun 27; 121(26):5131-7.Blood2013-05-21T00:00:002013Perspectives and future directions for epigenetics in hematology.23729667Shi FT, Kim H, Lu W, He Q, Liu D, Goodell MA, Wan M, Songyang ZThe Journal of biological chemistryTen-eleven translocation 1 (Tet1) is regulated by O-linked N-acetylglucosamine transferase (Ogt) for target gene repression in mouse embryonic stem cells. J Biol Chem. 2013 Jul 19; 288(29):20776-20784.J Biol Chem2013-05-31T00:00:002013Ten-eleven translocation 1 (Tet1) is regulated by O-linked N-acetylglucosamine transferase (Ogt) for target gene repression in mouse embryonic stem cells.23910078Goodell MACell stem cellParental permissions: H19 and keeping the stem cell progeny under control. Cell Stem Cell. 2013 Aug 01; 13(2):137-8.Cell Stem Cell2013-08-01T00:00:002013Parental permissions: H19 and keeping the stem cell progeny under control.2021-05-31NIHGOODELL, MARGARET A.2019-06-04Clonal Hematopoiesis, Aging and Genome Stability in PPM1D MutantsU01CA236972Principal Investigator2024-06-30NIHDONEHOWER, LAWRENCE A.;GOODELL, MARGARET A.2019-07-01PPM1D in Clonal Hematopoiesis and MalignanciesR01CA237291Principal InvestigatorDr. Shaulsky's GroupMemberAuthorship 9565001131563562Zeng H, He H, Guo L, Li J, Lee M, Han W, Guzman AG, Zang S, Zhou Y, Zhang X, Goodell MA, King KY, Sun D, Huang YCancer lettersAntibiotic treatment ameliorates Ten-eleven translocation 2 (TET2) loss-of-function associated hematological malignancies. Cancer Lett. 2019 12 28; 467:1-8.Cancer Lett2019-09-26T00:00:002019Antibiotic treatment ameliorates Ten-eleven translocation 2 (TET2) loss-of-function associated hematological malignancies.true1ProfessorProfessor2ProfessorProfessor3ChairChair4ProfessorProfessor5ProfessorProfessor6ProfessorProfessor7ProfessorProfessorAuthorship 975070431893524King KY, Huang Y, Nakada D, Goodell MAExperimental hematologyEnvironmental influences on clonal hematopoiesis. Exp Hematol. 2020 03; 83:66-73.Exp Hematol2019-12-29T00:00:002019Environmental influences on clonal hematopoiesis.Authorship 9757321431932841Zhang X, Wang X, Wang XQD, Su J, Putluri N, Zhou T, Qu Y, Jeong M, Guzman A, Rosas C, Huang Y, Sreekumar A, Li W, Goodell MABloodDnmt3a loss and Idh2 neomorphic mutations mutually potentiate malignant hematopoiesis. Blood. 2020 03 12; 135(11):845-856.Blood2020-03-12T00:00:002020Dnmt3a loss and Idh2 neomorphic mutations mutually potentiate malignant hematopoiesis.Authorship 976116631959038Choi BK, Fujiwara K, Dayaram T, Darlington Y, Dickerson J, Goodell MA, Donehower LACell cycle (Georgetown, Tex.)WIP1 dephosphorylation of p27Kip1 Serine 140 destabilizes p27Kip1 and reverses anti-proliferative effects of ATM phosphorylation. Cell Cycle. 2020 02; 19(4):479-491.Cell Cycle2020-01-20T00:00:002020WIP1 dephosphorylation of p27Kip1 Serine 140 destabilizes p27Kip1 and reverses anti-proliferative effects of ATM phosphorylation.Authorship 977544832029739Guo L, Li J, Zeng H, Guzman AG, Li T, Lee M, Zhou Y, Goodell MA, Stephan C, Davies PJA, Dawson MA, Sun D, Huang YNature communicationsA combination strategy targeting enhancer plasticity exerts synergistic lethality against BETi-resistant leukemia cells. Nat Commun. 2020 02 06; 11(1):740.Nat Commun2020-02-06T00:00:002020A combination strategy targeting enhancer plasticity exerts synergistic lethality against BETi-resistant leukemia cells.MIRAJEONGMIRA JEONG0.000000000000000.000000000000006092JEONG, MIRAAssistant ProfessorAuthorship 97904814Authorship 979321232183947Gundry MC, Goodell MA, Brunetti LCancer cellIt's All About MEis: Menin-MLL Inhibition Eradicates NPM1-Mutated and MLL-Rearranged Acute Leukemias in Mice. Cancer Cell. 2020 03 16; 37(3):267-269.Cancer Cell2020-03-16T00:00:002020It's All About MEis: Menin-MLL Inhibition Eradicates NPM1-Mutated and MLL-Rearranged Acute Leukemias in Mice.32159514Lavery LA, Ure K, Wan YW, Luo C, Trostle AJ, Wang W, Jin H, Lopez J, Lucero J, Durham MA, Castanon R, Nery JR, Liu Z, Goodell M, Ecker JR, Behrens MM, Zoghbi HYeLifeLosing Dnmt3a dependent methylation in inhibitory neurons impairs neural function by a mechanism impacting Rett syndrome. Elife. 2020 03 11; 9.Elife2020-03-11T00:00:002020Losing Dnmt3a dependent methylation in inhibitory neurons impairs neural function by a mechanism impacting Rett syndrome.Authorship 115494Authorship 9891482132386543Zhang X, Jeong M, Huang X, Wang XQ, Wang X, Zhou W, Shamim MS, Gore H, Himadewi P, Liu Y, Bochkov ID, Reyes J, Doty M, Huang YH, Jung H, Heikamp E, Aiden AP, Li W, Su J, Aiden EL, Goodell MAMolecular cellLarge DNA Methylation Nadirs Anchor Chromatin Loops Maintaining Hematopoietic Stem Cell Identity. Mol Cell. 2020 05 07; 78(3):506-521.e6.Mol Cell2020-05-07T00:00:002020Large DNA Methylation Nadirs Anchor Chromatin Loops Maintaining Hematopoietic Stem Cell Identity.Authorship 1134863Authorship 991394232513619Datar GK, Goodell MATrends in immunologyWhere There's Smoke, There's Fire: Inflammation Drives MDS. Trends Immunol. 2020 07; 41(7):558-560.Trends Immunol2020-06-05T00:00:002020Where There's Smoke, There's Fire: Inflammation Drives MDS.Authorship 9945052432673568Tovy A, Reyes JM, Gundry MC, Brunetti L, Lee-Six H, Petljak M, Park HJ, Guzman AG, Rosas C, Jeffries AR, Baple E, Mill J, Crosby AH, Sency V, Xin B, Machado HE, Castillo D, Weitzel JN, Li W, Stratton MR, Campbell PJ, Wang H, Sanders MA, Goodell MACell stem cellTissue-Biased Expansion of DNMT3A-Mutant Clones in a Mosaic Individual Is Associated with Conserved Epigenetic Erosion. Cell Stem Cell. 2020 08 06; 27(2):326-335.e4.Cell Stem Cell2020-07-15T00:00:002020Tissue-Biased Expansion of DNMT3A-Mutant Clones in a Mosaic Individual Is Associated with Conserved Epigenetic Erosion.Authorship 1117562Authorship 996046232746453Challen GA, Goodell MABloodClonal hematopoiesis: mechanisms driving dominance of stem cell clones. Blood. 2020 10 01; 136(14):1590-1598.Blood2020-10-01T00:00:002020Clonal hematopoiesis: mechanisms driving dominance of stem cell clones.true1Associate ProfessorAssociate ProfessorAuthorship 1177484https://www.bcm.edu/research/labs/katherine-kingKing Lab Website@_mirajeong@TheKingLabAuthorship 11801510Authorship 10046511933159179Sportoletti P, Sorcini D, Guzman AG, Reyes JM, Stella A, Marra A, Sartori S, Brunetti L, Rossi R, Papa BD, Adamo FM, Pianigiani G, Betti C, Scialdone A, Guarente V, Spinozzi G, Tini V, Martelli MP, Goodell MA, Falini BLeukemiaBcor deficiency perturbs erythro-megakaryopoiesis and cooperates with Dnmt3a loss in acute erythroid leukemia onset in mice. Leukemia. 2021 07; 35(7):1949-1963.Leukemia2020-11-06T00:00:002020Bcor deficiency perturbs erythro-megakaryopoiesis and cooperates with Dnmt3a loss in acute erythroid leukemia onset in mice.Authorship 1151406Authorship 12087318Authorship 1015246233833110Gu T, Goodell MAScience (New York, N.Y.)The push and pull of DNA methylation. Science. 2021 04 09; 372(6538):128-129.Science2021-04-09T00:00:002021The push and pull of DNA methylation.Authorship 1218803Authorship 10205492234092059Tovy A, Rosas C, Gaikwad AS, Medrano G, Zhang L, Reyes JM, Huang YH, Arakawa T, Kurtz K, Conneely SE, Guzman AG, Aguilar R, Gao A, Chen CW, Kim JJ, Carter MT, Lasa-Aranzasti A, Valenzuela I, Van Maldergem L, Brunetti L, Hicks MJ, Marcogliese AN, Goodell MA, Rau REHaematologicaPerturbed hematopoiesis in individuals with germline DNMT3A overgrowth Tatton-Brown-Rahman syndrome. Haematologica. 2022 04 01; 107(4):887-898.Haematologica2022-04-01T00:00:002022Perturbed hematopoiesis in individuals with germline DNMT3A overgrowth Tatton-Brown-Rahman syndrome.Authorship 10264091134321240Goldberg L, Negi V, Chung YJ, Onozawa M, Zhu YJ, Walker RL, Pierce R, Patel DP, Krausz KW, Gonzalez FJ, Goodell MA, Rodriguez BAT, Meltzer PS, Aplan PDCancer researchMutant Idh2 Cooperates with a NUP98-HOXD13 Fusion to Induce Early Immature Thymocyte Precursor ALL. Cancer Res. 2021 10 01; 81(19):5033-5046.Cancer Res2021-07-28T00:00:002021Mutant Idh2 Cooperates with a NUP98-HOXD13 Fusion to Induce Early Immature Thymocyte Precursor ALL.Authorship 10282922434429321Huang YH, Chen CW, Sundaramurthy V, Slabicki M, Hao D, Watson CJ, Tovy A, Reyes JM, Dakhova O, Crovetti BR, Galonska C, Lee M, Brunetti L, Zhou Y, Tatton-Brown K, Huang Y, Cheng X, Meissner A, Valk PJM, Van Maldergem L, Sanders MA, Blundell JR, Li W, Ebert BL, Goodell MACancer discoverySystematic Profiling of DNMT3A Variants Reveals Protein Instability Mediated by the DCAF8 E3 Ubiquitin Ligase Adaptor. Cancer Discov. 2022 01; 12(1):220-235.Cancer Discov2021-08-24T00:00:002021Systematic Profiling of DNMT3A Variants Reveals Protein Instability Mediated by the DCAF8 E3 Ubiquitin Ligase Adaptor.Authorship 10292511534492683Rogers JH, Gupta R, Reyes JM, Gundry MC, Medrano G, Guzman A, Aguilar R, Conneely SE, Song T, Johnson C, Barnes S, Cristobal CDD, Kurtz K, Brunetti L, Goodell MA, Rau REBlood advancesModeling IKZF1 lesions in B-ALL reveals distinct chemosensitivity patterns and potential therapeutic vulnerabilities. Blood Adv. 2021 10 12; 5(19):3876-3890.Blood Adv2021-10-12T00:00:002021Modeling IKZF1 lesions in B-ALL reveals distinct chemosensitivity patterns and potential therapeutic vulnerabilities.https://www.bcm.edu/research/faculty-labs/rachel-rau-labRau Lab Twitter Tweets Harvard TweetsAuthorship 1372325Authorship 1383112124167195Kim SJ, Zhao H, Hardikar S, Singh AK, Goodell MA, Chen TBloodA DNMT3A mutation common in AML exhibits dominant-negative effects in murine ES cells. Blood. 2013 Dec 12; 122(25):4086-9.Blood2013-10-28T00:00:002013A DNMT3A mutation common in AML exhibits dominant-negative effects in murine ES cells.24270360Jeong M, Sun D, Luo M, Huang Y, Challen GA, Rodriguez B, Zhang X, Chavez L, Wang H, Hannah R, Kim SB, Yang L, Ko M, Chen R, G?ttgens B, Lee JS, Gunaratne P, Godley LA, Darlington GJ, Rao A, Li W, Goodell MANature geneticsLarge conserved domains of low DNA methylation maintained by Dnmt3a. Nat Genet. 2014 Jan; 46(1):17-23.Nat Genet2013-11-24T00:00:002013Large conserved domains of low DNA methylation maintained by Dnmt3a.Authorship 10456921535534561Gu T, Hao D, Woo J, Huang TW, Guo L, Lin X, Guzman AG, Tovy A, Rosas C, Jeong M, Zhou Y, Deneen B, Huang Y, Li W, Goodell MANature geneticsThe disordered N-terminal domain of DNMT3A recognizes H2AK119ub and is required for postnatal development. Nat Genet. 2022 05; 54(5):625-636.Nat Genet2022-05-09T00:00:002022The disordered N-terminal domain of DNMT3A recognizes H2AK119ub and is required for postnatal development.35635747Tovy A, Reyes JM, Zhang L, Huang YH, Rosas C, Daquinag AC, Guzman A, Ramabadran R, Chen CW, Gu T, Gupta S, Ortinau L, Park D, Cox AR, Rau RE, Hartig SM, Kolonin MG, Goodell MAeLifeConstitutive loss of DNMT3A causes morbid obesity through misregulation of adipogenesis. Elife. 2022 05 30; 11.Elife2022-05-30T00:00:002022Constitutive loss of DNMT3A causes morbid obesity through misregulation of adipogenesis.Authorship 104686018Authorship 1047128335657598Zhang L, Hsu JI, Goodell MAMolecular cancer research : MCRPPM1D in Solid and Hematologic Malignancies: Friend and Foe? Mol Cancer Res. 2022 09 02; 20(9):1365-1378.Mol Cancer Res2022-09-02T00:00:002022PPM1D in Solid and Hematologic Malignancies: Friend and Foe?Authorship 1050550935821803Walsh K, Raghavachari N, Kerr C, Bick AG, Cummings SR, Druley T, Dunbar CE, Genovese G, Goodell MA, Jaiswal S, Maciejewski J, Natarajan P, Shindyapina AV, Shuldiner AR, Van Den Akker EB, Vijg JFrontiers in agingClonal Hematopoiesis Analyses in Clinical, Epidemiologic, and Genetic Aging Studies to Unravel Underlying Mechanisms of Age-Related Dysfunction in Humans. Front Aging. 2022; 3:841796.Front Aging2022-03-08T00:00:002022Clonal Hematopoiesis Analyses in Clinical, Epidemiologic, and Genetic Aging Studies to Unravel Underlying Mechanisms of Age-Related Dysfunction in Humans.Authorship 10510546Authorship 1050851235859206Brunet A, Goodell MA, Rando TANature reviews. Molecular cell biologyAgeing and rejuvenation of tissue stem cells and their niches. Nat Rev Mol Cell Biol. 2023 01; 24(1):45-62.Nat Rev Mol Cell Biol2022-07-20T00:00:002022Ageing and rejuvenation of tissue stem cells and their niches.35866897Sandoval JE, Ramabadran R, Stillson N, Sarah L, Fujimori DG, Goodell MA, Reich NJournal of medicinal chemistryFirst-in-Class Allosteric Inhibitors of DNMT3A Disrupt Protein-Protein Interactions and Induce Acute Myeloid Leukemia Cell Differentiation. J Med Chem. 2022 08 11; 65(15):10554-10566.J Med Chem2022-07-22T00:00:002022First-in-Class Allosteric Inhibitors of DNMT3A Disrupt Protein-Protein Interactions and Induce Acute Myeloid Leukemia Cell Differentiation.Authorship 10685808Authorship 106869014Authorship 10680652237118510Buckley MT, Sun ED, George BM, Liu L, Schaum N, Xu L, Reyes JM, Goodell MA, Weissman IL, Wyss-Coray T, Rando TA, Brunet ANature agingCell-type-specific aging clocks to quantify aging and rejuvenation in neurogenic regions of the brain. Nat Aging. 2023 01; 3(1):121-137.Nat Aging2022-12-19T00:00:002022Cell-type-specific aging clocks to quantify aging and rejuvenation in neurogenic regions of the brain.37024683Ramabadran R, Wang JH, Reyes JM, Guzman AG, Gupta S, Rosas C, Brunetti L, Gundry MC, Tovy A, Long H, Gu T, Cullen SM, Tyagi S, Rux D, Kim JJ, Kornblau SM, Kyba M, Stossi F, Rau RE, Takahashi K, Westbrook TF, Goodell MANature cell biologyDNMT3A-coordinated splicing governs the stem state switch towards differentiation in embryonic and haematopoietic stem cells. Nat Cell Biol. 2023 04; 25(4):528-539.Nat Cell Biol2023-04-06T00:00:002023DNMT3A-coordinated splicing governs the stem state switch towards differentiation in embryonic and haematopoietic stem cells.37080206Liu L, Kim S, Buckley MT, Reyes JM, Kang J, Tian L, Wang M, Lieu A, Mao M, Rodriguez-Mateo C, Ishak HD, Jeong M, Wu JC, Goodell MA, Brunet A, Rando TACell stem cellExercise reprograms the inflammatory landscape of multiple stem cell compartments during mammalian aging. Cell Stem Cell. 2023 05 04; 30(5):689-705.e4.Cell Stem Cell2023-04-19T00:00:002023Exercise reprograms the inflammatory landscape of multiple stem cell compartments during mammalian aging.Authorship 130921true1ProfessorProfessorAuthorship 10777058Authorship 10790126237693622Zhang L, Hsu JI, Braekeleer ED, Chen CW, Patel TD, Martell AG, Guzman AG, Wohlan K, Waldvogel SM, Urya H, Tovy A, Callen E, Murdaugh R, Richard R, Jansen S, Vissers L, de Vries BBA, Nussenzweig A, Huang S, Coarfa C, Anastas JN, Takahashi K, Vassiliou G, Goodell MAbioRxiv : the preprint server for biologySOD1 is a synthetic lethal target in PPM1D-mutant leukemia cells. bioRxiv. 2024 Jan 17.bioRxiv2024-01-17T00:00:002024SOD1 is a synthetic lethal target in PPM1D-mutant leukemia cells.37561983Franch-Exp?sito S, Mehine M, Ptashkin RN, Bolton KL, Bandlamudi C, Srinivasan P, Zhang L, Goodell MA, Gedvilaite E, Menghrajani K, S?nchez-Vela P, Mandelker D, Comen E, Norton L, Benayed R, Gao T, Papaemmanuil E, Taylor B, Levine R, Offit K, Stadler Z, Berger MF, Zehir AJCO precision oncologyAssociations Between Cancer Predisposition Mutations and Clonal Hematopoiesis in Patients With Solid Tumors. JCO Precis Oncol. 2023 08; 7:e2300070.JCO Precis Oncol2023-08-01T00:00:002023Associations Between Cancer Predisposition Mutations and Clonal Hematopoiesis in Patients With Solid Tumors.true1Assistant ProfessorAssistant Professortrue1Adjunct Associate ProfessorAdjunct Associate ProfessorAuthorship 10816302137863054Chen CW, Zhang L, Dutta R, Niroula A, Miller PG, Gibson CJ, Bick AG, Reyes JM, Lee YT, Tovy A, Gu T, Waldvogel S, Chen YH, Venters BJ, Est?ve PO, Pradhan S, Keogh MC, Natarajan P, Takahashi K, Sperling AS, Goodell MACell stem cellSRCAP mutations drive clonal hematopoiesis through epigenetic and DNA repair dysregulation. Cell Stem Cell. 2023 11 02; 30(11):1503-1519.e8.Cell Stem Cell2023-10-19T00:00:002023SRCAP mutations drive clonal hematopoiesis through epigenetic and DNA repair dysregulation.Authorship 10825731837884767Hong T, Li J, Guo L, Cavalier M, Wang T, Dou Y, DeLaFuente A, Fang S, Guzman A, Wohlan K, Kapadia C, Rosas C, Yang Y, Yin CC, Li S, You MJ, Cheng X, Goodell MA, Zhou Y, Huang YNature agingTET2 modulates spatial relocalization of heterochromatin in aged hematopoietic stem and progenitor cells. Nat Aging. 2023 Nov; 3(11):1387-1400.Nat Aging2023-10-26T00:00:002023TET2 modulates spatial relocalization of heterochromatin in aged hematopoietic stem and progenitor cells.Authorship 202602true1Adjunct Assistant ProfessorAdjunct Assistant ProfessorAuthorship 10859561038149948Kapadia CD, Rosas G, Thakkar SG, Wu M, Torrano V, Wang T, Grilley BJ, Heslop HE, Ramos CA, Goodell MA, Lulla PDCytotherapyIncipient clonal hematopoiesis is accelerated following CD30.CAR-T therapy. Cytotherapy. 2024 Mar; 26(3):261-265.Cytotherapy2023-12-26T00:00:002023Incipient clonal hematopoiesis is accelerated following CD30.CAR-T therapy.Authorship 174742Authorship 10881472138306995Chen CW, Zhang L, Dutta R, Niroula A, Miller PG, Gibson CJ, Bick AG, Reyes JM, Lee YT, Tovy A, Gu T, Waldvogel S, Chen YH, Venters BJ, Est?ve PO, Pradhan S, Keogh MC, Natarajan P, Takahashi K, Sperling AS, Goodell MACell stem cellSRCAP mutations drive clonal hematopoiesis through epigenetic and DNA repair dysregulation. Cell Stem Cell. 2024 Feb 01; 31(2):275-277.Cell Stem Cell2024-02-01T00:00:002024SRCAP mutations drive clonal hematopoiesis through epigenetic and DNA repair dysregulation.Authorship 10897762138414863Reyes JM, Tovy A, Zhang L, Bortoletto AS, Rosas C, Chen CW, Waldvogel SM, Guzman AG, Aguilar R, Gupta S, Liu L, Buckley MT, Patel KR, Marcogliese AN, Li Y, Curry CV, Rando T, Brunet A, Parchem RJ, Rau RE, Goodell MAiScienceHematologic DNMT3A reduction and high-fat diet synergize to promote weight gain and tissue inflammation. iScience. 2024 Mar 15; 27(3):109122.iScience2024-02-05T00:00:002024Hematologic DNMT3A reduction and high-fat diet synergize to promote weight gain and tissue inflammation.Authorship 1090008238438628Kapadia CD, Goodell MANature agingTissue mosaicism following stem cell aging: blood as an exemplar. Nat Aging. 2024 Mar; 4(3):295-308.Nat Aging2024-03-04T00:00:002024Tissue mosaicism following stem cell aging: blood as an exemplar.true1ProfessorProfessortrue1ProfessorProfessortrue1ProfessorProfessortrue1ProfessorProfessortrue1Assistant ProfessorAssistant ProfessorAuthorship 210042Authorship 249442Authorship 22805Authorship 254492Authorship 2624015Authorship 204464Authorship 303268Authorship 242632Authorship 34872Authorship 252923Authorship 2671810Authorship 398443Authorship 45007Authorship 312919Authorship 141452324439802Cullen SM, Mayle A, Rossi L, Goodell MACurrent topics in developmental biologyHematopoietic stem cell development: an epigenetic journey. Curr Top Dev Biol. 2014; 107:39-75.Curr Top Dev Biol2014-01-01T00:00:002014Hematopoietic stem cell development: an epigenetic journey.Authorship 318144Authorship 49863Authorship 364334Authorship 388893Authorship 398425Authorship 410505Authorship 410944Authorship 14640211Authorship 1467081Authorship 14693716Authorship 58916524792119Sun D, Luo M, Jeong M, Rodriguez B, Xia Z, Hannah R, Wang H, Le T, Faull KF, Chen R, Gu H, Bock C, Meissner A, G?ttgens B, Darlington GJ, Li W, Goodell MACell stem cellEpigenomic profiling of young and aged HSCs reveals concerted changes during aging that reinforce self-renewal. Cell Stem Cell. 2014 May 01; 14(5):673-88.Cell Stem Cell2014-05-01T00:00:002014Epigenomic profiling of young and aged HSCs reveals concerted changes during aging that reinforce self-renewal.24870234Rodgers JT, King KY, Brett JO, Cromie MJ, Charville GW, Maguire KK, Brunson C, Mastey N, Liu L, Tsai CR, Goodell MA, Rando TANaturemTORC1 controls the adaptive transition of quiescent stem cells from G0 to G(Alert). Nature. 2014 Jun 19; 510(7505):393-6.Nature2014-05-25T00:00:002014mTORC1 controls the adaptive transition of quiescent stem cells from G0 to G(Alert).24980745Goodell MAThe Journal of experimental medicineA gallon of sweat to make a pint of blood. J Exp Med. 2014 Jun 30; 211(7):1271-2.J Exp Med2014-06-30T00:00:002014A gallon of sweat to make a pint of blood.Authorship 454712Authorship 46586Authorship 481282Authorship 688716Authorship 493052Authorship 503462Authorship 51385Authorship 148676223714004Cullen SM, Goodell MAGenome biologyRising from the crypt: decreasing DNA methylation during differentiation of the small intestine. Genome Biol. 2013 May 28; 14(5):116.Genome Biol2013-05-28T00:00:002013Rising from the crypt: decreasing DNA methylation during differentiation of the small intestine.Authorship 721735Authorship 556853Authorship 555324Authorship 794485Authorship 563425Authorship 584782Authorship 1505717Authorship 15114916Authorship 151394224565500Sun D, Xi Y, Rodriguez B, Park HJ, Tong P, Meong M, Goodell MA, Li WGenome biologyMOABS: model based analysis of bisulfite sequencing data. Genome Biol. 2014 Feb 24; 15(2):R38.Genome Biol2014-02-24T00:00:002014MOABS: model based analysis of bisulfite sequencing data.24993071Jeong M, Goodell MAExperimental hematologyNew answers to old questions from genome-wide maps of DNA methylation in hematopoietic cells. Exp Hematol. 2014 Aug; 42(8):609-17.Exp Hematol2014-06-30T00:00:002014New answers to old questions from genome-wide maps of DNA methylation in hematopoietic cells.25130491Challen GA, Sun D, Mayle A, Jeong M, Luo M, Rodriguez B, Mallaney C, Celik H, Yang L, Xia Z, Cullen S, Berg J, Zheng Y, Darlington GJ, Li W, Goodell MACell stem cellDnmt3a and Dnmt3b have overlapping and distinct functions in hematopoietic stem cells. Cell Stem Cell. 2014 Sep 04; 15(3):350-364.Cell Stem Cell2014-08-14T00:00:002014Dnmt3a and Dnmt3b have overlapping and distinct functions in hematopoietic stem cells.Authorship 616753Authorship 64261Authorship 6350014Authorship 6518918Authorship 908705Authorship 964497Authorship 989856