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This is a "connection" page, showing publications co-authored by DAVID LONARD and BERT O'MALLEY.
DAVID LONARD
Connection Strength
11.845
BERT O'MALLEY
  1. Molecular Pathways: Targeting Steroid Receptor Coactivators in Cancer. Clin Cancer Res. 2016 Nov 15; 22(22):5403-5407.
    View in: PubMed
    Score: 0.558
  2. Bufalin is a steroid receptor coactivator inhibitor-response. Cancer Res. 2015 Mar 15; 75(6):1157.
    View in: PubMed
    Score: 0.501
  3. Nuclear receptor coregulators: modulators of pathology and therapeutic targets. Nat Rev Endocrinol. 2012 Oct; 8(10):598-604.
    View in: PubMed
    Score: 0.416
  4. Minireview: the SRC family of coactivators: an entr?e to understanding a subset of polygenic diseases? Mol Endocrinol. 2010 Feb; 24(2):279-85.
    View in: PubMed
    Score: 0.346
  5. Emerging roles of the ubiquitin proteasome system in nuclear hormone receptor signaling. Prog Mol Biol Transl Sci. 2009; 87:117-35.
    View in: PubMed
    Score: 0.345
  6. Gene transcription: two worlds merged. Nature. 2008 Apr 24; 452(7190):946-7.
    View in: PubMed
    Score: 0.312
  7. SRC-3 transcription-coupled activation, degradation, and the ubiquitin clock: is there enough coactivator to go around in cells? Sci Signal. 2008 Apr 01; 1(13):pe16.
    View in: PubMed
    Score: 0.310
  8. Nuclear receptor coregulators: judges, juries, and executioners of cellular regulation. Mol Cell. 2007 Sep 07; 27(5):691-700.
    View in: PubMed
    Score: 0.298
  9. Nuclear receptor coregulators and human disease. Endocr Rev. 2007 Aug; 28(5):575-87.
    View in: PubMed
    Score: 0.295
  10. The expanding cosmos of nuclear receptor coactivators. Cell. 2006 May 05; 125(3):411-4.
    View in: PubMed
    Score: 0.272
  11. Expanding functional diversity of the coactivators. Trends Biochem Sci. 2005 Mar; 30(3):126-32.
    View in: PubMed
    Score: 0.251
  12. Transcriptional coactivation of NRF2 signaling in cardiac fibroblasts promotes resistance to oxidative stress. J Mol Cell Cardiol. 2024 Sep; 194:70-84.
    View in: PubMed
    Score: 0.239
  13. Steroid receptor coactivators in Treg and Th17 cell biology and function. Front Immunol. 2024; 15:1389041.
    View in: PubMed
    Score: 0.236
  14. Selective estrogen receptor modulators 4-hydroxytamoxifen and raloxifene impact the stability and function of SRC-1 and SRC-3 coactivator proteins. Mol Cell Biol. 2004 Jan; 24(1):14-24.
    View in: PubMed
    Score: 0.231
  15. Steroid receptor coactivator 3 is a key modulator of regulatory T cell-mediated tumor evasion. Proc Natl Acad Sci U S A. 2023 06 06; 120(23):e2221707120.
    View in: PubMed
    Score: 0.222
  16. Steroid Receptor Coactivator-3 is a Key Modulator of Regulatory T Cell-Mediated Tumor Evasion. bioRxiv. 2023 Mar 29.
    View in: PubMed
    Score: 0.219
  17. Enhancer-promoter entanglement explains their transcriptional interdependence. Proc Natl Acad Sci U S A. 2023 01 24; 120(4):e2216436120.
    View in: PubMed
    Score: 0.216
  18. Steroid receptor coactivators - their role in immunity. Front Immunol. 2022; 13:1079011.
    View in: PubMed
    Score: 0.215
  19. A steroid receptor coactivator small molecule "stimulator" attenuates post-stroke ischemic brain injury. Front Mol Neurosci. 2022; 15:1055295.
    View in: PubMed
    Score: 0.214
  20. Steroid receptor coactivator-3 inhibition generates breast cancer antitumor immune microenvironment. Breast Cancer Res. 2022 10 31; 24(1):73.
    View in: PubMed
    Score: 0.213
  21. Spatial definition of the human progesterone receptor-B transcriptional complex. iScience. 2022 Nov 18; 25(11):105321.
    View in: PubMed
    Score: 0.212
  22. Reply to: Target expression is a relevant factor in synthetic lethal screens. Commun Biol. 2022 08 19; 5(1):836.
    View in: PubMed
    Score: 0.210
  23. Defining the mammalian coactivation of hepatic 12-h clock and lipid metabolism. Cell Rep. 2022 03 08; 38(10):110491.
    View in: PubMed
    Score: 0.204
  24. Development of improved SRC-3 inhibitors as breast cancer therapeutic agents. Endocr Relat Cancer. 2021 08 13; 28(10):657-670.
    View in: PubMed
    Score: 0.196
  25. A genome-scale CRISPR Cas9 dropout screen identifies synthetically lethal targets in SRC-3 inhibited cancer cells. Commun Biol. 2021 03 25; 4(1):399.
    View in: PubMed
    Score: 0.191
  26. Wound Healing-related Functions of the p160 Steroid Receptor Coactivator Family. Endocrinology. 2021 03 01; 162(3).
    View in: PubMed
    Score: 0.190
  27. Steroid receptor coactivator 3 (SRC-3/AIB1) is enriched and functional in mouse and human Tregs. Sci Rep. 2021 02 09; 11(1):3441.
    View in: PubMed
    Score: 0.189
  28. Drug Combination in Cancer Treatment-From Cocktails to Conjugated Combinations. Cancers (Basel). 2021 Feb 07; 13(4).
    View in: PubMed
    Score: 0.189
  29. Emerging roles of steroid receptor coactivators in stromal cell responses. J Endocrinol. 2021 02; 248(2):R41-R50.
    View in: PubMed
    Score: 0.189
  30. XBP1 links the 12-hour clock to NAFLD and regulation of membrane fluidity and lipid homeostasis. Nat Commun. 2020 12 04; 11(1):6215.
    View in: PubMed
    Score: 0.187
  31. A steroid receptor coactivator stimulator (MCB-613) attenuates adverse remodeling after myocardial infarction. Proc Natl Acad Sci U S A. 2020 12 08; 117(49):31353-31364.
    View in: PubMed
    Score: 0.186
  32. The 26S proteasome is required for estrogen receptor-alpha and coactivator turnover and for efficient estrogen receptor-alpha transactivation. Mol Cell. 2000 Jun; 5(6):939-48.
    View in: PubMed
    Score: 0.180
  33. Author Correction: Drug-induced PD-L1 expression and cell stress response in breast cancer cells can be balanced by drug combination. Sci Rep. 2020 Mar 05; 10(1):4463.
    View in: PubMed
    Score: 0.177
  34. Drug-induced PD-L1 expression and cell stress response in breast cancer cells can be balanced by drug combination. Sci Rep. 2019 10 22; 9(1):15099.
    View in: PubMed
    Score: 0.173
  35. SRC-3 Coactivator Governs Dynamic Estrogen-Induced Chromatin Looping Interactions during Transcription. Mol Cell. 2018 05 17; 70(4):679-694.e7.
    View in: PubMed
    Score: 0.157
  36. Targeting SRC Coactivators Blocks the Tumor-Initiating Capacity of Cancer Stem-like Cells. Cancer Res. 2017 08 15; 77(16):4293-4304.
    View in: PubMed
    Score: 0.147
  37. The Role of Steroid Receptor Coactivators in Hormone Dependent Cancers and Their Potential as Therapeutic Targets. Horm Cancer. 2016 08; 7(4):229-35.
    View in: PubMed
    Score: 0.136
  38. HER2 Signaling Drives DNA Anabolism and Proliferation through SRC-3 Phosphorylation and E2F1-Regulated Genes. Cancer Res. 2016 Mar 15; 76(6):1463-75.
    View in: PubMed
    Score: 0.134
  39. Characterization of a Steroid Receptor Coactivator Small Molecule Stimulator that Overstimulates Cancer Cells and Leads to Cell Stress and Death. Cancer Cell. 2015 Aug 10; 28(2):240-52.
    View in: PubMed
    Score: 0.129
  40. CAPER is vital for energy and redox homeostasis by integrating glucose-induced mitochondrial functions via ERR-a-Gabpa and stress-induced adaptive responses via NF-?B-cMYC. PLoS Genet. 2015 Apr; 11(4):e1005116.
    View in: PubMed
    Score: 0.126
  41. Identification of verrucarin a as a potent and selective steroid receptor coactivator-3 small molecule inhibitor. PLoS One. 2014; 9(4):e95243.
    View in: PubMed
    Score: 0.118
  42. Steroid receptor coactivator 1 is an integrator of glucose and NAD+/NADH homeostasis. Mol Endocrinol. 2014 Mar; 28(3):395-405.
    View in: PubMed
    Score: 0.116
  43. Bufalin is a potent small-molecule inhibitor of the steroid receptor coactivators SRC-3 and SRC-1. Cancer Res. 2014 Mar 01; 74(5):1506-1517.
    View in: PubMed
    Score: 0.116
  44. Nuclear receptor coactivators: master regulators of human health and disease. Annu Rev Med. 2014; 65:279-92.
    View in: PubMed
    Score: 0.113
  45. Proteomic analysis of coregulators bound to ERa on DNA and nucleosomes reveals coregulator dynamics. Mol Cell. 2013 Jul 25; 51(2):185-99.
    View in: PubMed
    Score: 0.112
  46. SRC-3 coactivator regulates cell resistance to cytotoxic stress via TRAF4-mediated p53 destabilization. Genes Dev. 2013 Feb 01; 27(3):274-87.
    View in: PubMed
    Score: 0.109
  47. ERK3 signals through SRC-3 coactivator to promote human lung cancer cell invasion. J Clin Invest. 2012 May; 122(5):1869-80.
    View in: PubMed
    Score: 0.103
  48. Small molecule inhibition of the steroid receptor coactivators, SRC-3 and SRC-1. Mol Endocrinol. 2011 Dec; 25(12):2041-53.
    View in: PubMed
    Score: 0.100
  49. Tumor-suppressor role for the SPOP ubiquitin ligase in signal-dependent proteolysis of the oncogenic co-activator SRC-3/AIB1. Oncogene. 2011 Oct 20; 30(42):4350-64.
    View in: PubMed
    Score: 0.096
  50. Modulation of steroid hormone receptor activity. Prog Brain Res. 2010; 181:153-76.
    View in: PubMed
    Score: 0.088
  51. Estrogen receptor-a: molecular mechanisms and interactions with the ubiquitin proteasome system. Horm Mol Biol Clin Investig. 2010 Jan; 1(1):1-9.
    View in: PubMed
    Score: 0.088
  52. Multi-modulation of nuclear receptor coactivators through posttranslational modifications. Trends Endocrinol Metab. 2009 Jan; 20(1):8-15.
    View in: PubMed
    Score: 0.081
  53. Atypical protein kinase C regulates dual pathways for degradation of the oncogenic coactivator SRC-3/AIB1. Mol Cell. 2008 Feb 29; 29(4):465-76.
    View in: PubMed
    Score: 0.077
  54. A repressive role for prohibitin in estrogen signaling. Mol Endocrinol. 2008 Feb; 22(2):344-60.
    View in: PubMed
    Score: 0.075
  55. Ubiquitin- and ATP-independent proteolytic turnover of p21 by the REGgamma-proteasome pathway. Mol Cell. 2007 Jun 22; 26(6):831-42.
    View in: PubMed
    Score: 0.074
  56. SRC-3 coactivator functional lifetime is regulated by a phospho-dependent ubiquitin time clock. Cell. 2007 Jun 15; 129(6):1125-40.
    View in: PubMed
    Score: 0.073
  57. The SRC-3/AIB1 coactivator is degraded in a ubiquitin- and ATP-independent manner by the REGgamma proteasome. Cell. 2006 Jan 27; 124(2):381-92.
    View in: PubMed
    Score: 0.067
  58. Inhibition of the 26S proteasome blocks progesterone receptor-dependent transcription through failed recruitment of RNA polymerase II. J Steroid Biochem Mol Biol. 2005 Mar; 94(4):337-46.
    View in: PubMed
    Score: 0.063
  59. A contemporary understanding of progesterone receptor function. Mech Ageing Dev. 2004 Oct-Nov; 125(10-11):669-78.
    View in: PubMed
    Score: 0.061
  60. Inhibition of SRC-3 as a potential therapeutic strategy for aggressive mantle cell lymphoma. PLoS One. 2024; 19(4):e0289902.
    View in: PubMed
    Score: 0.059
  61. Lead Compound Development of SRC-3 Inhibitors with Improved Pharmacokinetic Properties and Anticancer Efficacy. J Med Chem. 2024 04 11; 67(7):5333-5350.
    View in: PubMed
    Score: 0.059
  62. Steroid receptor coactivator-2 drives epithelial reprogramming that enables murine embryo implantation. FASEB J. 2023 12; 37(12):e23313.
    View in: PubMed
    Score: 0.057
  63. Inhibition of SRC-3 as a potential therapeutic strategy for aggressive mantle cell lymphoma. Res Sq. 2023 Mar 10.
    View in: PubMed
    Score: 0.055
  64. Decidualization of human endometrial stromal cells requires steroid receptor coactivator-3. Front Reprod Health. 2022; 4:1033581.
    View in: PubMed
    Score: 0.054
  65. Targeting NSD2-mediated SRC-3 liquid-liquid phase separation sensitizes bortezomib treatment in multiple myeloma. Nat Commun. 2021 02 15; 12(1):1022.
    View in: PubMed
    Score: 0.047
  66. Steroid receptor coactivator-3 as a target for anaplastic thyroid cancer. Endocr Relat Cancer. 2020 04; 27(4):209-220.
    View in: PubMed
    Score: 0.045
  67. Proteasome-dependent degradation of the human estrogen receptor. Proc Natl Acad Sci U S A. 1999 Mar 02; 96(5):1858-62.
    View in: PubMed
    Score: 0.041
  68. The Angelman syndrome-associated protein, E6-AP, is a coactivator for the nuclear hormone receptor superfamily. Mol Cell Biol. 1999 Feb; 19(2):1182-9.
    View in: PubMed
    Score: 0.041
  69. SRC-3 inhibition blocks tumor growth of pancreatic ductal adenocarcinoma. Cancer Lett. 2019 02 01; 442:310-319.
    View in: PubMed
    Score: 0.040
  70. Proteomic profiling identifies key coactivators utilized by mutant ERa proteins as potential new therapeutic targets. Oncogene. 2018 08; 37(33):4581-4598.
    View in: PubMed
    Score: 0.039
  71. USP15-dependent lysosomal pathway controls p53-R175H turnover in ovarian cancer cells. Nat Commun. 2018 03 28; 9(1):1270.
    View in: PubMed
    Score: 0.039
  72. Development of potent small-molecule inhibitors to drug the undruggable steroid receptor coactivator-3. Proc Natl Acad Sci U S A. 2016 May 03; 113(18):4970-5.
    View in: PubMed
    Score: 0.034
  73. Steroid Receptor Coactivator-3 (SRC-3/AIB1) as a Novel Therapeutic Target in Triple Negative Breast Cancer and Its Inhibition with a Phospho-Bufalin Prodrug. PLoS One. 2015; 10(10):e0140011.
    View in: PubMed
    Score: 0.033
  74. Prostate cancer-associated mutations in speckle-type POZ protein (SPOP) regulate steroid receptor coactivator 3 protein turnover. Proc Natl Acad Sci U S A. 2013 Apr 23; 110(17):6997-7002.
    View in: PubMed
    Score: 0.027
  75. OTU Domain-containing ubiquitin aldehyde-binding protein 1 (OTUB1) deubiquitinates estrogen receptor (ER) alpha and affects ERalpha transcriptional activity. J Biol Chem. 2009 Jun 12; 284(24):16135-16145.
    View in: PubMed
    Score: 0.021
  76. Reduction of coactivator expression by antisense oligodeoxynucleotides inhibits ERalpha transcriptional activity and MCF-7 proliferation. Mol Endocrinol. 2002 Feb; 16(2):253-70.
    View in: PubMed
    Score: 0.013
Connection Strength

The connection strength for concepts is the sum of the scores for each matching publication.

Publication scores are based on many factors, including how long ago they were written and whether the person is a first or senior author.