DAVID LONARD to Humans
This is a "connection" page, showing publications DAVID LONARD has written about Humans.
Connection Strength
0.401
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Reply to: Target expression is a relevant factor in synthetic lethal screens. Commun Biol. 2022 08 19; 5(1):836.
Score: 0.022
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Development of improved SRC-3 inhibitors as breast cancer therapeutic agents. Endocr Relat Cancer. 2021 08 13; 28(10):657-670.
Score: 0.020
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A genome-scale CRISPR Cas9 dropout screen identifies synthetically lethal targets in SRC-3 inhibited cancer cells. Commun Biol. 2021 03 25; 4(1):399.
Score: 0.020
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Drug-induced PD-L1 expression and cell stress response in breast cancer cells can be balanced by drug combination. Sci Rep. 2019 10 22; 9(1):15099.
Score: 0.018
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Steroid receptor coactivators present a unique opportunity for drug development in hormone-dependent cancers. Biochem Pharmacol. 2017 09 15; 140:1-7.
Score: 0.015
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Molecular Pathways: Targeting Steroid Receptor Coactivators in Cancer. Clin Cancer Res. 2016 Nov 15; 22(22):5403-5407.
Score: 0.015
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Bufalin is a steroid receptor coactivator inhibitor-response. Cancer Res. 2015 Mar 15; 75(6):1157.
Score: 0.013
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Identification of verrucarin a as a potent and selective steroid receptor coactivator-3 small molecule inhibitor. PLoS One. 2014; 9(4):e95243.
Score: 0.012
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Nuclear receptor coregulators: modulators of pathology and therapeutic targets. Nat Rev Endocrinol. 2012 Oct; 8(10):598-604.
Score: 0.011
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Minireview: the SRC family of coactivators: an entr?e to understanding a subset of polygenic diseases? Mol Endocrinol. 2010 Feb; 24(2):279-85.
Score: 0.009
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Emerging roles of the ubiquitin proteasome system in nuclear hormone receptor signaling. Prog Mol Biol Transl Sci. 2009; 87:117-35.
Score: 0.009
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SRC-3 transcription-coupled activation, degradation, and the ubiquitin clock: is there enough coactivator to go around in cells? Sci Signal. 2008 Apr 01; 1(13):pe16.
Score: 0.008
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Nuclear receptor coregulators: judges, juries, and executioners of cellular regulation. Mol Cell. 2007 Sep 07; 27(5):691-700.
Score: 0.008
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Nuclear receptor coregulators and human disease. Endocr Rev. 2007 Aug; 28(5):575-87.
Score: 0.008
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The expanding cosmos of nuclear receptor coactivators. Cell. 2006 May 05; 125(3):411-4.
Score: 0.007
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Expanding functional diversity of the coactivators. Trends Biochem Sci. 2005 Mar; 30(3):126-32.
Score: 0.007
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Development of a Novel Amplifiable System to Quantify Hydrogen Peroxide in Living Cells. J Am Chem Soc. 2024 Aug 14; 146(32):22396-22404.
Score: 0.006
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Inhibition of SRC-3 as a potential therapeutic strategy for aggressive mantle cell lymphoma. PLoS One. 2024; 19(4):e0289902.
Score: 0.006
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Steroid receptor coactivators in Treg and Th17 cell biology and function. Front Immunol. 2024; 15:1389041.
Score: 0.006
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Lead Compound Development of SRC-3 Inhibitors with Improved Pharmacokinetic Properties and Anticancer Efficacy. J Med Chem. 2024 04 11; 67(7):5333-5350.
Score: 0.006
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Selective estrogen receptor modulators 4-hydroxytamoxifen and raloxifene impact the stability and function of SRC-1 and SRC-3 coactivator proteins. Mol Cell Biol. 2004 Jan; 24(1):14-24.
Score: 0.006
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Steroid receptor coactivator-2 drives epithelial reprogramming that enables murine embryo implantation. FASEB J. 2023 12; 37(12):e23313.
Score: 0.006
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Enhancer-promoter entanglement explains their transcriptional interdependence. Proc Natl Acad Sci U S A. 2023 01 24; 120(4):e2216436120.
Score: 0.006
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Steroid receptor coactivators - their role in immunity. Front Immunol. 2022; 13:1079011.
Score: 0.006
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Early growth response 1 transcription factor is essential for the pathogenic properties of human endometriotic epithelial cells. Reproduction. 2022 08 01; 164(2):41-54.
Score: 0.005
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Molecular perspectives on selective estrogen receptor modulators (SERMs): progress in understanding their tissue-specific agonist and antagonist actions. Steroids. 2002 Jan; 67(1):15-24.
Score: 0.005
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Wound Healing-related Functions of the p160 Steroid Receptor Coactivator Family. Endocrinology. 2021 03 01; 162(3).
Score: 0.005
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Targeting NSD2-mediated SRC-3 liquid-liquid phase separation sensitizes bortezomib treatment in multiple myeloma. Nat Commun. 2021 02 15; 12(1):1022.
Score: 0.005
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Steroid receptor coactivator 3 (SRC-3/AIB1) is enriched and functional in mouse and human Tregs. Sci Rep. 2021 02 09; 11(1):3441.
Score: 0.005
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Emerging roles of steroid receptor coactivators in stromal cell responses. J Endocrinol. 2021 02; 248(2):R41-R50.
Score: 0.005
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XBP1 links the 12-hour clock to NAFLD and regulation of membrane fluidity and lipid homeostasis. Nat Commun. 2020 12 04; 11(1):6215.
Score: 0.005
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The REG? inhibitor NIP30 increases sensitivity to chemotherapy in p53-deficient tumor cells. Nat Commun. 2020 08 06; 11(1):3904.
Score: 0.005
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The 26S proteasome is required for estrogen receptor-alpha and coactivator turnover and for efficient estrogen receptor-alpha transactivation. Mol Cell. 2000 Jun; 5(6):939-48.
Score: 0.005
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Steroid receptor coactivator-3 as a target for anaplastic thyroid cancer. Endocr Relat Cancer. 2020 04; 27(4):209-220.
Score: 0.005
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SRC-3 inhibition blocks tumor growth of pancreatic ductal adenocarcinoma. Cancer Lett. 2019 02 01; 442:310-319.
Score: 0.004
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SRC-3 Coactivator Governs Dynamic Estrogen-Induced Chromatin Looping Interactions during Transcription. Mol Cell. 2018 05 17; 70(4):679-694.e7.
Score: 0.004
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Proteomic profiling identifies key coactivators utilized by mutant ERa proteins as potential new therapeutic targets. Oncogene. 2018 08; 37(33):4581-4598.
Score: 0.004
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USP15-dependent lysosomal pathway controls p53-R175H turnover in ovarian cancer cells. Nat Commun. 2018 03 28; 9(1):1270.
Score: 0.004
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Human endometrial stromal cell decidualization requires transcriptional reprogramming by PLZF. Biol Reprod. 2018 01 01; 98(1):15-27.
Score: 0.004
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Targeting SRC Coactivators Blocks the Tumor-Initiating Capacity of Cancer Stem-like Cells. Cancer Res. 2017 08 15; 77(16):4293-4304.
Score: 0.004
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The Role of Steroid Receptor Coactivators in Hormone Dependent Cancers and Their Potential as Therapeutic Targets. Horm Cancer. 2016 08; 7(4):229-35.
Score: 0.004
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Development of potent small-molecule inhibitors to drug the undruggable steroid receptor coactivator-3. Proc Natl Acad Sci U S A. 2016 May 03; 113(18):4970-5.
Score: 0.004
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HER2 Signaling Drives DNA Anabolism and Proliferation through SRC-3 Phosphorylation and E2F1-Regulated Genes. Cancer Res. 2016 Mar 15; 76(6):1463-75.
Score: 0.003
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Steroid Receptor Coactivator-3 (SRC-3/AIB1) as a Novel Therapeutic Target in Triple Negative Breast Cancer and Its Inhibition with a Phospho-Bufalin Prodrug. PLoS One. 2015; 10(10):e0140011.
Score: 0.003
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Characterization of a Steroid Receptor Coactivator Small Molecule Stimulator that Overstimulates Cancer Cells and Leads to Cell Stress and Death. Cancer Cell. 2015 Aug 10; 28(2):240-52.
Score: 0.003
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Tamoxifen inhibits ER-negative breast cancer cell invasion and metastasis by accelerating Twist1 degradation. Int J Biol Sci. 2015; 11(5):618-28.
Score: 0.003
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CAPER is vital for energy and redox homeostasis by integrating glucose-induced mitochondrial functions via ERR-a-Gabpa and stress-induced adaptive responses via NF-?B-cMYC. PLoS Genet. 2015 Apr; 11(4):e1005116.
Score: 0.003
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Steroid receptor coactivator 1 is an integrator of glucose and NAD+/NADH homeostasis. Mol Endocrinol. 2014 Mar; 28(3):395-405.
Score: 0.003
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Bufalin is a potent small-molecule inhibitor of the steroid receptor coactivators SRC-3 and SRC-1. Cancer Res. 2014 Mar 01; 74(5):1506-1517.
Score: 0.003
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Nuclear receptor coactivators: master regulators of human health and disease. Annu Rev Med. 2014; 65:279-92.
Score: 0.003
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Proteomic analysis of coregulators bound to ERa on DNA and nucleosomes reveals coregulator dynamics. Mol Cell. 2013 Jul 25; 51(2):185-99.
Score: 0.003
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Prostate cancer-associated mutations in speckle-type POZ protein (SPOP) regulate steroid receptor coactivator 3 protein turnover. Proc Natl Acad Sci U S A. 2013 Apr 23; 110(17):6997-7002.
Score: 0.003
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SRC-3 coactivator regulates cell resistance to cytotoxic stress via TRAF4-mediated p53 destabilization. Genes Dev. 2013 Feb 01; 27(3):274-87.
Score: 0.003
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ERK3 signals through SRC-3 coactivator to promote human lung cancer cell invasion. J Clin Invest. 2012 May; 122(5):1869-80.
Score: 0.003
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Small molecule inhibition of the steroid receptor coactivators, SRC-3 and SRC-1. Mol Endocrinol. 2011 Dec; 25(12):2041-53.
Score: 0.003
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Tumor-suppressor role for the SPOP ubiquitin ligase in signal-dependent proteolysis of the oncogenic co-activator SRC-3/AIB1. Oncogene. 2011 Oct 20; 30(42):4350-64.
Score: 0.003
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REGgamma modulates p53 activity by regulating its cellular localization. J Cell Sci. 2010 Dec 01; 123(Pt 23):4076-84.
Score: 0.002
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Comparative analysis of REG{gamma} expression in mouse and human tissues. J Mol Cell Biol. 2010 Aug; 2(4):192-8.
Score: 0.002
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Modulation of steroid hormone receptor activity. Prog Brain Res. 2010; 181:153-76.
Score: 0.002
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OTU Domain-containing ubiquitin aldehyde-binding protein 1 (OTUB1) deubiquitinates estrogen receptor (ER) alpha and affects ERalpha transcriptional activity. J Biol Chem. 2009 Jun 12; 284(24):16135-16145.
Score: 0.002
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Multi-modulation of nuclear receptor coactivators through posttranslational modifications. Trends Endocrinol Metab. 2009 Jan; 20(1):8-15.
Score: 0.002
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Atypical protein kinase C regulates dual pathways for degradation of the oncogenic coactivator SRC-3/AIB1. Mol Cell. 2008 Feb 29; 29(4):465-76.
Score: 0.002
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A repressive role for prohibitin in estrogen signaling. Mol Endocrinol. 2008 Feb; 22(2):344-60.
Score: 0.002
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Ubiquitin- and ATP-independent proteolytic turnover of p21 by the REGgamma-proteasome pathway. Mol Cell. 2007 Jun 22; 26(6):831-42.
Score: 0.002
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SRC-3 coactivator functional lifetime is regulated by a phospho-dependent ubiquitin time clock. Cell. 2007 Jun 15; 129(6):1125-40.
Score: 0.002
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The SRC-3/AIB1 coactivator is degraded in a ubiquitin- and ATP-independent manner by the REGgamma proteasome. Cell. 2006 Jan 27; 124(2):381-92.
Score: 0.002
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Inhibition of the 26S proteasome blocks progesterone receptor-dependent transcription through failed recruitment of RNA polymerase II. J Steroid Biochem Mol Biol. 2005 Mar; 94(4):337-46.
Score: 0.002
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A contemporary understanding of progesterone receptor function. Mech Ageing Dev. 2004 Oct-Nov; 125(10-11):669-78.
Score: 0.002
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Specific ubiquitin-conjugating enzymes promote degradation of specific nuclear receptor coactivators. Mol Endocrinol. 2003 Jul; 17(7):1315-31.
Score: 0.001
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Reduction of coactivator expression by antisense oligodeoxynucleotides inhibits ERalpha transcriptional activity and MCF-7 proliferation. Mol Endocrinol. 2002 Feb; 16(2):253-70.
Score: 0.001
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Proteasome-dependent degradation of the human estrogen receptor. Proc Natl Acad Sci U S A. 1999 Mar 02; 96(5):1858-62.
Score: 0.001
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The Angelman syndrome-associated protein, E6-AP, is a coactivator for the nuclear hormone receptor superfamily. Mol Cell Biol. 1999 Feb; 19(2):1182-9.
Score: 0.001