JUAN BOTAS to Animals
This is a "connection" page, showing publications JUAN BOTAS has written about Animals.
Connection Strength
0.601
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Computational and functional prioritization identifies genes that rescue behavior and reduce tau protein in fly and human cell models of Alzheimer disease. Am J Hum Genet. 2025 May 01; 112(5):1081-1096.
Score: 0.052
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Integration of transcriptome-wide association study with neuronal dysfunction assays provides functional genomics evidence for Parkinson's disease genes. Hum Mol Genet. 2023 01 27; 32(4):685-695.
Score: 0.045
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Downregulation of glial genes involved in synaptic function mitigates Huntington's disease pathogenesis. Elife. 2021 04 19; 10.
Score: 0.039
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Genetic modifiers of MeCP2 function in Drosophila. PLoS Genet. 2008 Sep 05; 4(9):e1000179.
Score: 0.016
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Suppression of neurodegeneration and increased neurotransmission caused by expanded full-length huntingtin accumulating in the cytoplasm. Neuron. 2008 Jan 10; 57(1):27-40.
Score: 0.016
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RNA-binding proteins hnRNP A2/B1 and CUGBP1 suppress fragile X CGG premutation repeat-induced neurodegeneration in a Drosophila model of FXTAS. Neuron. 2007 Aug 16; 55(4):565-71.
Score: 0.015
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Drosophila researchers focus on human disease. Nat Genet. 2007 May; 39(5):589-91.
Score: 0.015
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Multi-epitope immunocapture of huntingtin reveals striatum-selective molecular signatures. Mol Syst Biol. 2025 May; 21(5):492-522.
Score: 0.013
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SPA-STOCSY: an automated tool for identifying annotated and non-annotated metabolites in high-throughput NMR spectra. Bioinformatics. 2023 10 03; 39(10).
Score: 0.012
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Tau polarizes an aging transcriptional signature to excitatory neurons and glia. Elife. 2023 May 23; 12.
Score: 0.011
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Functional screening of lysosomal storage disorder genes identifies modifiers of alpha-synuclein neurotoxicity. PLoS Genet. 2023 05; 19(5):e1010760.
Score: 0.011
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Evolutionarily conserved regulators of tau identify targets for new therapies. Neuron. 2023 03 15; 111(6):824-838.e7.
Score: 0.011
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Mouse and fly models of neurodegeneration. Trends Genet. 2002 Sep; 18(9):463-71.
Score: 0.011
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Cross-species genetic screens identify transglutaminase 5 as a regulator of polyglutamine-expanded ataxin-1. J Clin Invest. 2022 05 02; 132(9).
Score: 0.011
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Suppression of toxicity of the mutant huntingtin protein by its interacting compound, desonide. Proc Natl Acad Sci U S A. 2022 03 08; 119(10):e2114303119.
Score: 0.010
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Dynamics of huntingtin protein interactions in the striatum identifies candidate modifiers of Huntington disease. Cell Syst. 2022 04 20; 13(4):304-320.e5.
Score: 0.010
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Spinocerebellar Ataxia Type 1 protein Ataxin-1 is signaled to DNA damage by ataxia-telangiectasia mutated kinase. Hum Mol Genet. 2021 05 17; 30(8):706-715.
Score: 0.010
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Dual targeting of brain region-specific kinases potentiates neurological rescue in Spinocerebellar ataxia type 1. EMBO J. 2021 04 01; 40(7):e106106.
Score: 0.010
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Guidelines for the use and interpretation of assays for monitoring autophagy (4th edition)1. Autophagy. 2021 Jan; 17(1):1-382.
Score: 0.010
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Harnessing the paradoxical phenotypes of APOE ?2 and APOE ?4 to identify genetic modifiers in Alzheimer's disease. Alzheimers Dement. 2021 05; 17(5):831-846.
Score: 0.010
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Identification of genes that modify ataxin-1-induced neurodegeneration. Nature. 2000 Nov 02; 408(6808):101-6.
Score: 0.010
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The LIM homeodomain protein dLim1 defines a subclass of neurons within the embryonic ventral nerve cord of Drosophila. Mech Dev. 1999 Nov; 88(2):195-205.
Score: 0.009
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Cross-species genetic screens to identify kinase targets for APP reduction in Alzheimer's disease. Hum Mol Genet. 2019 06 15; 28(12):2014-2029.
Score: 0.009
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Functional dominance among Hox genes: repression dominates activation in the regulation of Dpp. Development. 1998 Dec; 125(24):4949-57.
Score: 0.008
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A Druggable Genome Screen Identifies Modifiers of a-Synuclein Levels via a Tiered Cross-Species Validation Approach. J Neurosci. 2018 10 24; 38(43):9286-9301.
Score: 0.008
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PAK1 regulates ATXN1 levels providing an opportunity to modify its toxicity in spinocerebellar ataxia type 1. Hum Mol Genet. 2018 08 15; 27(16):2863-2873.
Score: 0.008
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High-Throughput Functional Analysis Distinguishes Pathogenic, Nonpathogenic, and Compensatory Transcriptional Changes in Neurodegeneration. Cell Syst. 2018 07 25; 7(1):28-40.e4.
Score: 0.008
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Inhibition of PIP4K? ameliorates the pathological effects of mutant huntingtin protein. Elife. 2017 12 26; 6.
Score: 0.008
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TRIM28 regulates the nuclear accumulation and toxicity of both alpha-synuclein and tau. Elife. 2016 10 25; 5.
Score: 0.007
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Reduction of Nuak1 Decreases Tau and Reverses Phenotypes in a Tauopathy Mouse Model. Neuron. 2016 Oct 19; 92(2):407-418.
Score: 0.007
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Metal Homeostasis Regulators Suppress FRDA Phenotypes in a Drosophila Model of the Disease. PLoS One. 2016; 11(7):e0159209.
Score: 0.007
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Uncoupling neuronal death and dysfunction in Drosophila models of neurodegenerative disease. Acta Neuropathol Commun. 2016 06 23; 4(1):62.
Score: 0.007
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Chromosomal binding sites of Ultrabithorax homeotic proteins. Mech Dev. 1996 May; 56(1-2):129-38.
Score: 0.007
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Integrated genomics and proteomics define huntingtin CAG length-dependent networks in mice. Nat Neurosci. 2016 Apr; 19(4):623-33.
Score: 0.007
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Drosophila Mitf regulates the V-ATPase and the lysosomal-autophagic pathway. Autophagy. 2016; 12(3):484-98.
Score: 0.007
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Huntingtin proteolysis releases non-polyQ fragments that cause toxicity through dynamin 1 dysregulation. EMBO J. 2015 Sep 02; 34(17):2255-71.
Score: 0.007
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TORC1 Inhibition by Rapamycin Promotes Antioxidant Defences in a Drosophila Model of Friedreich's Ataxia. PLoS One. 2015; 10(7):e0132376.
Score: 0.007
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A striatal-enriched intronic GPCR modulates huntingtin levels and toxicity. Elife. 2015 Mar 04; 4.
Score: 0.006
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Targeting ATM ameliorates mutant Huntingtin toxicity in cell and animal models of Huntington's disease. Sci Transl Med. 2014 Dec 24; 6(268):268ra178.
Score: 0.006
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Direct regulation of decapentaplegic by Ultrabithorax and its role in Drosophila midgut morphogenesis. Cell. 1994 Feb 11; 76(3):461-75.
Score: 0.006
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Control of morphogenesis and differentiation by HOM/Hox genes. Curr Opin Cell Biol. 1993 Dec; 5(6):1015-22.
Score: 0.006
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RAS-MAPK-MSK1 pathway modulates ataxin 1 protein levels and toxicity in SCA1. Nature. 2013 Jun 20; 498(7454):325-331.
Score: 0.006
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Identification of NUB1 as a suppressor of mutant Huntington toxicity via enhanced protein clearance. Nat Neurosci. 2013 May; 16(5):562-70.
Score: 0.006
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Tau loss attenuates neuronal network hyperexcitability in mouse and Drosophila genetic models of epilepsy. J Neurosci. 2013 Jan 23; 33(4):1651-9.
Score: 0.006
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A genome-scale RNA-interference screen identifies RRAS signaling as a pathologic feature of Huntington's disease. PLoS Genet. 2012; 8(11):e1003042.
Score: 0.006
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Network organization of the huntingtin proteomic interactome in mammalian brain. Neuron. 2012 Jul 12; 75(1):41-57.
Score: 0.005
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Inhibition of lipid signaling enzyme diacylglycerol kinase epsilon attenuates mutant huntingtin toxicity. J Biol Chem. 2012 Jun 15; 287(25):21204-13.
Score: 0.005
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Matrix metalloproteinases are modifiers of huntingtin proteolysis and toxicity in Huntington's disease. Neuron. 2010 Jul 29; 67(2):199-212.
Score: 0.005
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The Drosophila FMRP and LARK RNA-binding proteins function together to regulate eye development and circadian behavior. J Neurosci. 2008 Oct 08; 28(41):10200-5.
Score: 0.004
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dAtaxin-2 mediates expanded Ataxin-1-induced neurodegeneration in a Drosophila model of SCA1. PLoS Genet. 2007 Dec 28; 3(12):e234.
Score: 0.004
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Comparative analysis of genetic modifiers in Drosophila points to common and distinct mechanisms of pathogenesis among polyglutamine diseases. Hum Mol Genet. 2008 Feb 01; 17(3):376-90.
Score: 0.004
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Argonaute-2-dependent rescue of a Drosophila model of FXTAS by FRAXE premutation repeat. Hum Mol Genet. 2007 Oct 01; 16(19):2326-32.
Score: 0.004
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Huntingtin interacting proteins are genetic modifiers of neurodegeneration. PLoS Genet. 2007 May 11; 3(5):e82.
Score: 0.004
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Proteome analysis of soluble nuclear proteins reveals that HMGB1/2 suppress genotoxic stress in polyglutamine diseases. Nat Cell Biol. 2007 Apr; 9(4):402-14.
Score: 0.004
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ATAXIN-1 interacts with the repressor Capicua in its native complex to cause SCA1 neuropathology. Cell. 2006 Dec 29; 127(7):1335-47.
Score: 0.004
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Neurotoxic protein expression reveals connections between the circadian clock and mating behavior in Drosophila. Proc Natl Acad Sci U S A. 2006 Sep 05; 103(36):13537-42.
Score: 0.004
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CHIP protects from the neurotoxicity of expanded and wild-type ataxin-1 and promotes their ubiquitination and degradation. J Biol Chem. 2006 Sep 08; 281(36):26714-24.
Score: 0.004
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MBNL1 and CUGBP1 modify expanded CUG-induced toxicity in a Drosophila model of myotonic dystrophy type 1. Hum Mol Genet. 2006 Jul 01; 15(13):2138-45.
Score: 0.004
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The AXH domain of Ataxin-1 mediates neurodegeneration through its interaction with Gfi-1/Senseless proteins. Cell. 2005 Aug 26; 122(4):633-44.
Score: 0.003
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Interaction of Akt-phosphorylated ataxin-1 with 14-3-3 mediates neurodegeneration in spinocerebellar ataxia type 1. Cell. 2003 May 16; 113(4):457-68.
Score: 0.003
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Assessing the impact of comparative genomic sequence data on the functional annotation of the Drosophila genome. Genome Biol. 2002; 3(12):RESEARCH0086.
Score: 0.003
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Gene-dose titration analysis in the search of trans-regulatory genes in Drosophila. EMBO J. 1982; 1(3):307-10.
Score: 0.003
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Direct regulation of the muscle-identity gene apterous by a Hox protein in the somatic mesoderm. Development. 2001 Apr; 128(8):1221-30.
Score: 0.002
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Conserved overlapping and reciprocal expression of msh/Msx1 and apterous/Lhx2 in Drosophila and mice. Mech Dev. 2000 Dec; 99(1-2):177-81.
Score: 0.002
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The level of DLDB/CHIP controls the activity of the LIM homeodomain protein apterous: evidence for a functional tetramer complex in vivo. EMBO J. 2000 Jun 01; 19(11):2602-14.
Score: 0.002
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Conservation of the expression and function of apterous orthologs in Drosophila and mammals. Proc Natl Acad Sci U S A. 1999 Mar 02; 96(5):2165-70.
Score: 0.002
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The relative expression amounts of apterous and its co-factor dLdb/Chip are critical for dorso-ventral compartmentalization in the Drosophila wing. EMBO J. 1998 Dec 01; 17(23):6846-53.
Score: 0.002
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Lhx2, a vertebrate homologue of apterous, regulates vertebrate limb outgrowth. Development. 1998 Oct; 125(20):3925-34.
Score: 0.002
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Protein complex formation between Msx1 and Lhx2 homeoproteins is incompatible with DNA binding activity. Differentiation. 1998 Jul; 63(3):151-7.
Score: 0.002
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The DNA binding specificity of Ultrabithorax is modulated by cooperative interactions with extradenticle, another homeoprotein. Cell. 1994 Aug 26; 78(4):603-15.
Score: 0.002
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The Drosophila 18 wheeler is required for morphogenesis and has striking similarities to Toll. Development. 1994 Apr; 120(4):885-99.
Score: 0.002
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Negative autoregulation by Ultrabithorax controls the level and pattern of its expression. Development. 1993 Jan; 117(1):387-99.
Score: 0.001
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Homeotic genes of the Bithorax complex repress limb development in the abdomen of the Drosophila embryo through the target gene Distal-less. Cell. 1992 Oct 30; 71(3):437-50.
Score: 0.001
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Homeotic transformations of the abdominal segments of Drosophila caused by breaking or deleting a central portion of the bithorax complex. J Embryol Exp Morphol. 1983 Dec; 78:319-41.
Score: 0.001