JEFFREYNOEBELSJEFFREY NOEBELS0.000000000000000.000000000000003151NOEBELS, JEFFREYProfessorprns:coAuthorOfcoauthor ofprns:endDateend dateFaculty Rankprns:fullNamefull nameprns:grantAwardedBygrant awarded byprns:hasAuthorListauthor listprns:hasFacultyRankhas faculty rankprns:hasNetworkhas networkprns:hasPublicationVenuepublished inprns:informationResourceReferenceinformation resource referenceprns:isPrimaryPositionis primary positionprns:latitudelatitudeprns:longitudelongitudeprns:mainImagephotoprns:maxWeightmaximum weightprns:medlineTAjournal title abbreviationprns:meshDescriptorUIMeSH DescriptorUIprns:meshSemanticGroupNameMeSH semantic group nameprns:minWeightminimum weightprns:numberOfAuthorsnumber of authorsprns:numberOfConnectionsnumber of connectionsprns:numberOfPublicationsnumber of publicationsprns:personIdPerson IDprns:personInPrimaryPositionperson in primary positionprns:physicalNeighborOfphysical neighborprns:positionInDepartmentposition in departmentprns:positionInDivisionposition in divisionprns:predicateNodepredicate nodeprns:principalInvestigatorNameprincipal investigator nameprns:publicationDatepublication dateprns:similarTosimilar toprns:sortOrdersort orderprns:startDatestart dateprns:uniquenessWeightuniqueness weightprns:yearyearAcademic ArticleArticleDocumentbibo:pmidPubMed IdentifierAddressvivo:address1address line 1vivo:addressCitycityvivo:addressPostalCodepostal codevivo:addressStatestate or provinceAgreementvivo:authorInAuthorshipselected publicationsvivo:authorRankauthor rank in publicationAuthorshipDepartmentDivisionGrantvivo:hasResearchArearesearch areasvivo:hasResearcherRoleresearch activitiesvivo:hrJobTitleHR job titleInformation Resourcevivo:linkedAuthorlinked authorvivo:linkedInformationResourcelinked information resourcevivo:mailingAddressmailing addressvivo:personInPositionpositionsPositionvivo:positionInOrganizationposition in organizationvivo:preferredTitlepreferred titleResearcher Rolevivo:researcherRoleOfresearcher role ofRolevivo:roleContributesTocontributes tovivo:sponsorAwardIdsponsor award idrdf:predicatepredicaterdf:typetyperdfs:labellabelConceptAgentfoaf:firstNamefirst namefoaf:lastNamelast nameOrganizationPersonAuthorship 787051Authorship 800871Authorship 841965Authorship 865656Authorship 852345Authorship 853447Authorship 881635Authorship 896246Authorship 923081Authorship 909325Authorship 941696Authorship 944824Authorship 947976Authorship 981485Authorship 1034884Authorship 1056125Authorship 109022Authorship 1094874Authorship 1097583Authorship 1098149Authorship 1104418Authorship 1137311Authorship 1146826Authorship 1152834Authorship 1206475Authorship 12200024Authorship 139786Authorship 1442014Authorship 152731Authorship 23453Authorship 2346513Authorship 250781Authorship 1600932Authorship 16055710Authorship 161799124947601Nakao A, Miki T, Shimono K, Oka H, Numata T, Kiyonaka S, Matsushita K, Ogura H, Niidome T, Noebels JL, Wakamori M, Imoto K, Mori YPflugers Archiv : European journal of physiologyCompromised maturation of GABAergic inhibition underlies abnormal network activity in the hippocampus of epileptic Ca2+ channel mutant mice, tottering. Pflugers Arch. 2015 Apr; 467(4):737-52.Pflugers Arch2014-06-20T00:00:002014Compromised maturation of GABAergic inhibition underlies abnormal network activity in the hippocampus of epileptic Ca2+ channel mutant mice, tottering.25710836Noebels JNature neurosciencePathway-driven discovery of epilepsy genes. Nat Neurosci. 2015 Mar; 18(3):344-50.Nat Neurosci2015-02-24T00:00:002015Pathway-driven discovery of epilepsy genes.25855492Aiba I, Noebels JLScience translational medicineSpreading depolarization in the brainstem mediates sudden cardiorespiratory arrest in mouse SUDEP models. Sci Transl Med. 2015 Apr 08; 7(282):282ra46.Sci Transl Med2015-04-08T00:00:002015Spreading depolarization in the brainstem mediates sudden cardiorespiratory arrest in mouse SUDEP models.Authorship 260984Authorship 2926013Authorship 307512Authorship 333154Authorship 363518Authorship 36982Anesthesiology & PeriOperative MedicineMD AndersonHUI-LINPANHUI-LIN PAN9317PAN, HUI-LINProfessorAuthorship 424431Authorship 48278Authorship 488173Authorship 494901Authorship 542636Authorship 564669Authorship 5814012Authorship 602626Authorship 604025Authorship 619151Authorship 634681Authorship 642933Authorship 728612Authorship 736695Authorship 874752Authorship 921151Authorship 951012Authorship 963403Authorship 979276Authorship 9922142871726Noebels JLAdvances in neurologyMutational analysis of inherited epilepsies. Adv Neurol. 1986; 44:97-113.Adv Neurol1986-01-01T00:00:001986Mutational analysis of inherited epilepsies.404001Noebels JL, Pedley TABrain researchAnatomic localization of topically applied [14C]penicillin during experimental focal epilepsy in cat neocortex. Brain Res. 1977 Apr 15; 125(2):293-303.Brain Res1977-04-15T00:00:001977Anatomic localization of topically applied [14C]penicillin during experimental focal epilepsy in cat neocortex.QINGLONGMIAOQINGLONG MIAO10363MIAO, QINGLONGAssistant Professor702194Noebels JL, Prince DAJournal of neurophysiologyDevelopment of focal seizures in cerebral cortex: role of axon terminal bursting. J Neurophysiol. 1978 Sep; 41(5):1267-81.J Neurophysiol1978-09-01T00:00:001978Development of focal seizures in cerebral cortex: role of axon terminal bursting.7828829Frankel WN, Taylor BA, Noebels JL, Lutz CMGeneticsGenetic epilepsy model derived from common inbred mouse strains. Genetics. 1994 Oct; 138(2):481-9.Genetics1994-10-01T00:00:001994Genetic epilepsy model derived from common inbred mouse strains.690664Noebels JL, Roth WT, Kopell BSJournal of the neurological sciencesCortical slow potentials and the occipital EEG in congenital blindness. J Neurol Sci. 1978 Jun; 37(1-2):51-8.J Neurol Sci1978-06-01T00:00:001978Cortical slow potentials and the occipital EEG in congenital blindness.7557442Sutherland ML, Delaney TA, Noebels JLGeneMolecular characterization of a high-affinity mouse glutamate transporter. Gene. 1995 Sep 11; 162(2):271-4.Gene1995-09-11T00:00:001995Molecular characterization of a high-affinity mouse glutamate transporter.8158221Helekar SA, Noebels JLJournal of neurophysiologyAnalysis of voltage-gated and synaptic conductances contributing to network excitability defects in the mutant mouse tottering. J Neurophysiol. 1994 Jan; 71(1):1-10.J Neurophysiol1994-01-01T00:00:001994Analysis of voltage-gated and synaptic conductances contributing to network excitability defects in the mutant mouse tottering.7476019Chafetz RS, Nahm WK, Noebels JLBrain research. Molecular brain researchAberrant expression of neuropeptide Y in hippocampal mossy fibers in the absence of local cell injury following the onset of spike-wave synchronization. Brain Res Mol Brain Res. 1995 Jul; 31(1-2):111-21.Brain Res Mol Brain Res1995-07-01T00:00:001995Aberrant expression of neuropeptide Y in hippocampal mossy fibers in the absence of local cell injury following the onset of spike-wave synchronization.8406478Buckwalter MS, Testa CM, Noebels JL, Camper SAGenomicsGenetic mapping and evaluation of candidate genes for spasmodic, a neurological mouse mutation with abnormal startle response. Genomics. 1993 Aug; 17(2):279-86.Genomics1993-08-01T00:00:001993Genetic mapping and evaluation of candidate genes for spasmodic, a neurological mouse mutation with abnormal startle response.8601800Sutherland ML, Delaney TA, Noebels JLThe Journal of neuroscience : the official journal of the Society for NeuroscienceGlutamate transporter mRNA expression in proliferative zones of the developing and adult murine CNS. J Neurosci. 1996 Apr 01; 16(7):2191-207.J Neurosci1996-04-01T00:00:001996Glutamate transporter mRNA expression in proliferative zones of the developing and adult murine CNS.1188986Schwartzkroin PA, Futamachi KJ, Noebels JL, Prince DABrain researchTranscallosal effects of a cortical epileptiform focus. Brain Res. 1975 Nov 28; 99(1):59-68.Brain Res1975-11-28T00:00:001975Transcallosal effects of a cortical epileptiform focus.8845157Wang H, Allen ML, Grigg JJ, Noebels JL, Tempel BLNeuronHypomyelination alters K+ channel expression in mouse mutants shiverer and Trembler. Neuron. 1995 Dec; 15(6):1337-47.Neuron1995-12-01T00:00:001995Hypomyelination alters K+ channel expression in mouse mutants shiverer and Trembler.9065835Di Pasquale E, Keegan KD, Noebels JLJournal of neurophysiologyIncreased excitability and inward rectification in layer V cortical pyramidal neurons in the epileptic mutant mouse Stargazer. J Neurophysiol. 1997 Feb; 77(2):621-31.J Neurophysiol1997-02-01T00:00:001997Increased excitability and inward rectification in layer V cortical pyramidal neurons in the epileptic mutant mouse Stargazer.9195990Cattanach BM, Barr JA, Beechey CV, Martin J, Noebels J, Jones JMammalian genome : official journal of the International Mammalian Genome SocietyA candidate model for Angelman syndrome in the mouse. Mamm Genome. 1997 Jul; 8(7):472-8.Mamm Genome1997-07-01T00:00:001997A candidate model for Angelman syndrome in the mouse.9246461Noebels JL, Sutherland ML, Nahm WK, DiPasquale ECold Spring Harbor symposia on quantitative biologyMolecular and cellular plasticity in developing epileptic brain. Cold Spring Harb Symp Quant Biol. 1996; 61:319-26.Cold Spring Harb Symp Quant Biol1996-01-01T00:00:001996Molecular and cellular plasticity in developing epileptic brain.9502793Westenbroek RE, Bausch SB, Lin RC, Franck JE, Noebels JL, Catterall WAThe Journal of neuroscience : the official journal of the Society for NeuroscienceUpregulation of L-type Ca2+ channels in reactive astrocytes after brain injury, hypomyelination, and ischemia. J Neurosci. 1998 Apr 01; 18(7):2321-34.J Neurosci1998-04-01T00:00:001998Upregulation of L-type Ca2+ channels in reactive astrocytes after brain injury, hypomyelination, and ischemia.8296456Wu SM, Qiao X, Noebels JL, Yang XLVision researchLocalization and modulatory actions of zinc in vertebrate retina. Vision Res. 1993 Dec; 33(18):2611-6.Vision Res1993-12-01T00:00:001993Localization and modulatory actions of zinc in vertebrate retina.9989613Clark GD, Noebels JLAnnals of neurologyCortin disaster: lissencephaly genes spell double trouble for the developing brain. Ann Neurol. 1999 Feb; 45(2):141-2.Ann Neurol1999-02-01T00:00:001999Cortin disaster: lissencephaly genes spell double trouble for the developing brain.10051663Sutherland ML, Williams SH, Abedi R, Overbeek PA, Pfaffinger PJ, Noebels JLProceedings of the National Academy of Sciences of the United States of AmericaOverexpression of a Shaker-type potassium channel in mammalian central nervous system dysregulates native potassium channel gene expression. Proc Natl Acad Sci U S A. 1999 Mar 02; 96(5):2451-5.Proc Natl Acad Sci U S A1999-03-02T00:00:001999Overexpression of a Shaker-type potassium channel in mammalian central nervous system dysregulates native potassium channel gene expression.10328888Burgess DL, Biddlecome GH, McDonough SI, Diaz ME, Zilinski CA, Bean BP, Campbell KP, Noebels JLMolecular and cellular neurosciencesbeta subunit reshuffling modifies N- and P/Q-type Ca2+ channel subunit compositions in lethargic mouse brain. Mol Cell Neurosci. 1999 Apr; 13(4):293-311.Mol Cell Neurosci1999-04-01T00:00:001999beta subunit reshuffling modifies N- and P/Q-type Ca2+ channel subunit compositions in lethargic mouse brain.10404176Hartmann HA, Colom LV, Sutherland ML, Noebels JLNature neuroscienceSelective localization of cardiac SCN5A sodium channels in limbic regions of rat brain. Nat Neurosci. 1999 Jul; 2(7):593-5.Nat Neurosci1999-07-01T00:00:001999Selective localization of cardiac SCN5A sodium channels in limbic regions of rat brain.10613843Burgess DL, Davis CF, Gefrides LA, Noebels JLGenome researchIdentification of three novel Ca(2+) channel gamma subunit genes reveals molecular diversification by tandem and chromosome duplication. Genome Res. 1999 Dec; 9(12):1204-13.Genome Res1999-12-01T00:00:001999Identification of three novel Ca(2+) channel gamma subunit genes reveals molecular diversification by tandem and chromosome duplication.10639171Liu M, Pleasure SJ, Collins AE, Noebels JL, Naya FJ, Tsai MJ, Lowenstein DHProceedings of the National Academy of Sciences of the United States of AmericaLoss of BETA2/NeuroD leads to malformation of the dentate gyrus and epilepsy. Proc Natl Acad Sci U S A. 2000 Jan 18; 97(2):865-70.Proc Natl Acad Sci U S A2000-01-18T00:00:002000Loss of BETA2/NeuroD leads to malformation of the dentate gyrus and epilepsy.10826987Steinlein OK, Noebels JLCurrent opinion in genetics & developmentIon channels and epilepsy in man and mouse. Curr Opin Genet Dev. 2000 Jun; 10(3):286-91.Curr Opin Genet Dev2000-06-01T00:00:002000Ion channels and epilepsy in man and mouse.Authorship 2987417Authorship 2995272Authorship 3004381Authorship 3019366Authorship 3024184Authorship 3059501226162324Glasscock E, Voigt N, McCauley MD, Sun Q, Li N, Chiang DY, Zhou XB, Molina CE, Thomas D, Schmidt C, Skapura DG, Noebels JL, Dobrev D, Wehrens XHBasic research in cardiologyExpression and function of Kv1.1 potassium channels in human atria from patients with atrial fibrillation. Basic Res Cardiol. 2015 Sep; 110(5):505.Basic Res Cardiol2015-07-11T00:00:002015Expression and function of Kv1.1 potassium channels in human atria from patients with atrial fibrillation.26269648Kole MJ, Qian J, Waase MP, Klassen TL, Chen TT, Augustine GJ, Noebels JLThe Journal of neuroscience : the official journal of the Society for NeuroscienceSelective Loss of Presynaptic Potassium Channel Clusters at the Cerebellar Basket Cell Terminal Pinceau in Adam11 Mutants Reveals Their Role in Ephaptic Control of Purkinje Cell Firing. J Neurosci. 2015 Aug 12; 35(32):11433-44.J Neurosci2015-08-12T00:00:002015Selective Loss of Presynaptic Potassium Channel Clusters at the Cerebellar Basket Cell Terminal Pinceau in Adam11 Mutants Reveals Their Role in Ephaptic Control of Purkinje Cell Firing.26494436Lhatoo S, Noebels J, Whittemore V, NINDS Center for SUDEP ResearchEpilepsiaSudden unexpected death in epilepsy: Identifying risk and preventing mortality. Epilepsia. 2015 Nov; 56(11):1700-6.Epilepsia2015-10-23T00:00:002015Sudden unexpected death in epilepsy: Identifying risk and preventing mortality.26525453Noebels JLCold Spring Harbor perspectives in medicineSingle-Gene Determinants of Epilepsy Comorbidity. Cold Spring Harb Perspect Med. 2015 Nov 02; 5(11).Cold Spring Harb Perspect Med2015-11-02T00:00:002015Single-Gene Determinants of Epilepsy Comorbidity.26663261Maheshwari A, Marks RL, Yu KM, Noebels JLEpilepsiaShift in interictal relative gamma power as a novel biomarker for drug response in two mouse models of absence epilepsy. Epilepsia. 2016 Jan; 57(1):79-88.Epilepsia2015-12-10T00:00:002015Shift in interictal relative gamma power as a novel biomarker for drug response in two mouse models of absence epilepsy.26758833Bomben VC, Aiba I, Qian J, Mark MD, Herlitze S, Noebels JLThe Journal of neuroscience : the official journal of the Society for NeuroscienceIsolated P/Q Calcium Channel Deletion in Layer VI Corticothalamic Neurons Generates Absence Epilepsy. J Neurosci. 2016 Jan 13; 36(2):405-18.J Neurosci2016-01-13T00:00:002016Isolated P/Q Calcium Channel Deletion in Layer VI Corticothalamic Neurons Generates Absence Epilepsy.9806543Pennacchio LA, Bouley DM, Higgins KM, Scott MP, Noebels JL, Myers RMNature geneticsProgressive ataxia, myoclonic epilepsy and cerebellar apoptosis in cystatin B-deficient mice. Nat Genet. 1998 Nov; 20(3):251-8.Nat Genet1998-11-01T00:00:001998Progressive ataxia, myoclonic epilepsy and cerebellar apoptosis in cystatin B-deficient mice.9808466Jiang YH, Armstrong D, Albrecht U, Atkins CM, Noebels JL, Eichele G, Sweatt JD, Beaudet ALNeuronMutation of the Angelman ubiquitin ligase in mice causes increased cytoplasmic p53 and deficits of contextual learning and long-term potentiation. Neuron. 1998 Oct; 21(4):799-811.Neuron1998-10-01T00:00:001998Mutation of the Angelman ubiquitin ligase in mice causes increased cytoplasmic p53 and deficits of contextual learning and long-term potentiation.11160387Zwingman TA, Neumann PE, Noebels JL, Herrup KThe Journal of neuroscience : the official journal of the Society for NeuroscienceRocker is a new variant of the voltage-dependent calcium channel gene Cacna1a. J Neurosci. 2001 Feb 15; 21(4):1169-78.J Neurosci2001-02-15T00:00:002001Rocker is a new variant of the voltage-dependent calcium channel gene Cacna1a.8789939Noebels JLNeuronTargeting epilepsy genes. Neuron. 1996 Feb; 16(2):241-4.Neuron1996-02-01T00:00:001996Targeting epilepsy genes.11319771Qiao X, Suri C, Knusel B, Noebels JLJournal of neuroscience researchAbsence of hippocampal mossy fiber sprouting in transgenic mice overexpressing brain-derived neurotrophic factor. J Neurosci Res. 2001 May 01; 64(3):268-76.J Neurosci Res2001-05-01T00:00:002001Absence of hippocampal mossy fiber sprouting in transgenic mice overexpressing brain-derived neurotrophic factor.11356859Qian J, Noebels JLThe Journal of neuroscience : the official journal of the Society for NeurosciencePresynaptic Ca2+ channels and neurotransmitter release at the terminal of a mouse cortical neuron. J Neurosci. 2001 Jun 01; 21(11):3721-8.J Neurosci2001-06-01T00:00:002001Presynaptic Ca2+ channels and neurotransmitter release at the terminal of a mouse cortical neuron.11706087Jacobs MP, Fischbach GD, Davis MR, Dichter MA, Dingledine R, Lowenstein DH, Morrell MJ, Noebels JL, Rogawski MA, Spencer SS, Theodore WHNeurologyFuture directions for epilepsy research. Neurology. 2001 Nov 13; 57(9):1536-42.Neurology2001-11-13T00:00:002001Future directions for epilepsy research.10414295Burgess DL, Noebels JLAnnals of the New York Academy of SciencesVoltage-dependent calcium channel mutations in neurological disease. Ann N Y Acad Sci. 1999 Apr 30; 868:199-212.Ann N Y Acad Sci1999-04-30T00:00:001999Voltage-dependent calcium channel mutations in neurological disease.11771641Noebels JLNovartis Foundation symposiumSodium channel gene expression and epilepsy. Novartis Found Symp. 2002; 241:109-20; discussion 120-3, 226-32.Novartis Found Symp2002-01-01T00:00:002002Sodium channel gene expression and epilepsy.1572065Helekar SA, Noebels JLBrain research. Developmental brain researchA burst-dependent hippocampal excitability defect elicited by potassium at the developmental onset of spike-wave seizures in the Tottering mutant. Brain Res Dev Brain Res. 1992 Feb 21; 65(2):205-10.Brain Res Dev Brain Res1992-02-21T00:00:001992A burst-dependent hippocampal excitability defect elicited by potassium at the developmental onset of spike-wave seizures in the Tottering mutant.8993682Noebels JL, Qiao X, Nahm WKAdvances in neurologyNeurogenetic approaches to axon sprouting in the hippocampus. Adv Neurol. 1997; 72:35-44.Adv Neurol1997-01-01T00:00:001997Neurogenetic approaches to axon sprouting in the hippocampus.10627593Qian J, Noebels JLThe Journal of neuroscience : the official journal of the Society for NeurosciencePresynaptic Ca(2+) influx at a mouse central synapse with Ca(2+) channel subunit mutations. J Neurosci. 2000 Jan 01; 20(1):163-70.J Neurosci2000-01-01T00:00:002000Presynaptic Ca(2+) influx at a mouse central synapse with Ca(2+) channel subunit mutations.12034802Poolos NP, Das S, Clark GD, Lardizabal D, Noebels JL, Wyllie E, Dobyns WBNeurologyMales with epilepsy, complete subcortical band heterotopia, and somatic mosaicism for DCX. Neurology. 2002 May 28; 58(10):1559-62.Neurology2002-05-28T00:00:002002Males with epilepsy, complete subcortical band heterotopia, and somatic mosaicism for DCX.10643919Burgess DL, Matsuura T, Ashizawa T, Noebels JLEpilepsiaGenetic localization of the Ca2+ channel gene CACNG2 near SCA10 on chromosome 22q13. Epilepsia. 2000 Jan; 41(1):24-7.Epilepsia2000-01-01T00:00:002000Genetic localization of the Ca2+ channel gene CACNG2 near SCA10 on chromosome 22q13.9335342Cox GA, Lutz CM, Yang CL, Biemesderfer D, Bronson RT, Fu A, Aronson PS, Noebels JL, Frankel WNCellSodium/hydrogen exchanger gene defect in slow-wave epilepsy mutant mice. Cell. 1997 Oct 03; 91(1):139-48.Cell1997-10-03T00:00:001997Sodium/hydrogen exchanger gene defect in slow-wave epilepsy mutant mice.1318958Westenbroek RE, Noebels JL, Catterall WAThe Journal of neuroscience : the official journal of the Society for NeuroscienceElevated expression of type II Na+ channels in hypomyelinated axons of shiverer mouse brain. J Neurosci. 1992 Jun; 12(6):2259-67.J Neurosci1992-06-01T00:00:001992Elevated expression of type II Na+ channels in hypomyelinated axons of shiverer mouse brain.12533622Powell EM, Campbell DB, Stanwood GD, Davis C, Noebels JL, Levitt PThe Journal of neuroscience : the official journal of the Society for NeuroscienceGenetic disruption of cortical interneuron development causes region- and GABA cell type-specific deficits, epilepsy, and behavioral dysfunction. J Neurosci. 2003 Jan 15; 23(2):622-31.J Neurosci2003-01-15T00:00:002003Genetic disruption of cortical interneuron development causes region- and GABA cell type-specific deficits, epilepsy, and behavioral dysfunction.10961647Burgess DL, Noebels JLEpilepsiaCalcium channel defects in models of inherited generalized epilepsy. Epilepsia. 2000 Aug; 41(8):1074-5.Epilepsia2000-08-01T00:00:002000Calcium channel defects in models of inherited generalized epilepsy.11124984Lau D, Vega-Saenz de Miera EC, Contreras D, Ozaita A, Harvey M, Chow A, Noebels JL, Paylor R, Morgan JI, Leonard CS, Rudy BThe Journal of neuroscience : the official journal of the Society for NeuroscienceImpaired fast-spiking, suppressed cortical inhibition, and increased susceptibility to seizures in mice lacking Kv3.2 K+ channel proteins. J Neurosci. 2000 Dec 15; 20(24):9071-85.J Neurosci2000-12-15T00:00:002000Impaired fast-spiking, suppressed cortical inhibition, and increased susceptibility to seizures in mice lacking Kv3.2 K+ channel proteins.9697856Kantheti P, Qiao X, Diaz ME, Peden AA, Meyer GE, Carskadon SL, Kapfhamer D, Sufalko D, Robinson MS, Noebels JL, Burmeister MNeuronMutation in AP-3 delta in the mocha mouse links endosomal transport to storage deficiency in platelets, melanosomes, and synaptic vesicles. Neuron. 1998 Jul; 21(1):111-22.Neuron1998-07-01T00:00:001998Mutation in AP-3 delta in the mocha mouse links endosomal transport to storage deficiency in platelets, melanosomes, and synaptic vesicles.10514817Noebels JLAdvances in neurologySingle-gene models of epilepsy. Adv Neurol. 1999; 79:227-38.Adv Neurol1999-01-01T00:00:001999Single-gene models of epilepsy.15102918Chen C, Westenbroek RE, Xu X, Edwards CA, Sorenson DR, Chen Y, McEwen DP, O'Malley HA, Bharucha V, Meadows LS, Knudsen GA, Vilaythong A, Noebels JL, Saunders TL, Scheuer T, Shrager P, Catterall WA, Isom LLThe Journal of neuroscience : the official journal of the Society for NeuroscienceMice lacking sodium channel beta1 subunits display defects in neuronal excitability, sodium channel expression, and nodal architecture. J Neurosci. 2004 Apr 21; 24(16):4030-42.J Neurosci2004-04-21T00:00:002004Mice lacking sodium channel beta1 subunits display defects in neuronal excitability, sodium channel expression, and nodal architecture.6501 Fannin StHouston, 77030TX10961636Kellaway P, Mizrahi EM, Noebels JLEpilepsiaBenign focal epilepsies of childhood: genetically determined pathophysiology. Report of an international workshop. Epilepsia. 2000 Aug; 41(8):1049-50.Epilepsia2000-08-01T00:00:002000Benign focal epilepsies of childhood: genetically determined pathophysiology. Report of an international workshop.74Professor10Assistant Professor14Associate Professor46Distinguished Emeritus Professor47Distinguished Service Professor11170751Burgess DL, Gefrides LA, Foreman PJ, Noebels JLGenomicsA cluster of three novel Ca2+ channel gamma subunit genes on chromosome 19q13.4: evolution and expression profile of the gamma subunit gene family. Genomics. 2001 Feb 01; 71(3):339-50.Genomics2001-02-01T00:00:002001A cluster of three novel Ca2+ channel gamma subunit genes on chromosome 19q13.4: evolution and expression profile of the gamma subunit gene family.EVERTONEDMONDSONEVERTON EDMONDSON0.000000000000000.000000000000004842EDMONDSON, EVERTONProfessor16007083Cobos I, Calcagnotto ME, Vilaythong AJ, Thwin MT, Noebels JL, Baraban SC, Rubenstein JLNature neuroscienceMice lacking Dlx1 show subtype-specific loss of interneurons, reduced inhibition and epilepsy. Nat Neurosci. 2005 Aug; 8(8):1059-68.Nat Neurosci2005-07-10T00:00:002005Mice lacking Dlx1 show subtype-specific loss of interneurons, reduced inhibition and epilepsy.16145613Noebels JLEpilepsy currentsCalcium channel "gaiting" and absence epilepsy. Epilepsy Curr. 2005 May-Jun; 5(3):95-7.Epilepsy Curr2005-05-01T00:00:002005Calcium channel "gaiting" and absence epilepsy.16261134Brenner R, Chen QH, Vilaythong A, Toney GM, Noebels JL, Aldrich RWNature neuroscienceBK channel beta4 subunit reduces dentate gyrus excitability and protects against temporal lobe seizures. Nat Neurosci. 2005 Dec; 8(12):1752-9.Nat Neurosci2005-10-30T00:00:002005BK channel beta4 subunit reduces dentate gyrus excitability and protects against temporal lobe seizures.Pediatrics-Neur NRI CAIN12972176Qian J, Noebels JLEpilepsy researchTopiramate alters excitatory synaptic transmission in mouse hippocampus. Epilepsy Res. 2003 Aug; 55(3):225-33.Epilepsy Res2003-08-01T00:00:002003Topiramate alters excitatory synaptic transmission in mouse hippocampus.Authorship 319995212160743Shahbazian M, Young J, Yuva-Paylor L, Spencer C, Antalffy B, Noebels J, Armstrong D, Paylor R, Zoghbi HNeuronMice with truncated MeCP2 recapitulate many Rett syndrome features and display hyperacetylation of histone H3. Neuron. 2002 Jul 18; 35(2):243-54.Neuron2002-07-18T00:00:002002Mice with truncated MeCP2 recapitulate many Rett syndrome features and display hyperacetylation of histone H3.Authorship 3215292Authorship 323256126517286Siehr MS, Noebels JLCurrent opinion in neurobiologyEarly rescue of interneuron disease trajectory in developmental epilepsies. Curr Opin Neurobiol. 2016 Feb; 36:82-8.Curr Opin Neurobiol2015-10-27T00:00:002015Early rescue of interneuron disease trajectory in developmental epilepsies.26756385Horv?th A, Szucs A, Barcs G, Noebels JL, Kamondi AAlzheimer disease and associated disordersEpileptic Seizures in Alzheimer Disease: A Review. Alzheimer Dis Assoc Disord. 2016 Apr-Jun; 30(2):186-92.Alzheimer Dis Assoc Disord2016-04-01T00:00:002016Epileptic Seizures in Alzheimer Disease: A Review.27094436Noebels JForensic science, medicine, and pathologyHippocampal abnormalities and sudden childhood death. Forensic Sci Med Pathol. 2016 06; 12(2):198-9.Forensic Sci Med Pathol2016-04-19T00:00:002016Hippocampal abnormalities and sudden childhood death.14527270Noebels JLAnnual review of neuroscienceThe biology of epilepsy genes. Annu Rev Neurosci. 2003; 26:599-625.Annu Rev Neurosci2003-01-01T00:00:002003The biology of epilepsy genes.Authorship 3250843Authorship 325292227371672Holmes GL, Noebels JLCold Spring Harbor perspectives in medicineThe Epilepsy Spectrum: Targeting Future Research Challenges. Cold Spring Harb Perspect Med. 2016 07 01; 6(7).Cold Spring Harb Perspect Med2016-07-01T00:00:002016The Epilepsy Spectrum: Targeting Future Research Challenges.27482086Aiba I, Wehrens XH, Noebels JLProceedings of the National Academy of Sciences of the United States of AmericaLeaky RyR2 channels unleash a brainstem spreading depolarization mechanism of sudden cardiac death. Proc Natl Acad Sci U S A. 2016 08 16; 113(33):E4895-903.Proc Natl Acad Sci U S A2016-08-01T00:00:002016Leaky RyR2 channels unleash a brainstem spreading depolarization mechanism of sudden cardiac death.Authorship 326954627622563Hernandez CC, Klassen TL, Jackson LG, Gurba K, Hu N, Noebels JL, Macdonald RLPloS oneDeleterious Rare Variants Reveal Risk for Loss of GABAA Receptor Function in Patients with Genetic Epilepsy and in the General Population. PLoS One. 2016; 11(9):e0162883.PLoS One2016-09-13T00:00:002016Deleterious Rare Variants Reveal Risk for Loss of GABAA Receptor Function in Patients with Genetic Epilepsy and in the General Population.17785178Palop JJ, Chin J, Roberson ED, Wang J, Thwin MT, Bien-Ly N, Yoo J, Ho KO, Yu GQ, Kreitzer A, Finkbeiner S, Noebels JL, Mucke LNeuronAberrant excitatory neuronal activity and compensatory remodeling of inhibitory hippocampal circuits in mouse models of Alzheimer's disease. Neuron. 2007 Sep 06; 55(5):697-711.Neuron2007-09-06T00:00:002007Aberrant excitatory neuronal activity and compensatory remodeling of inhibitory hippocampal circuits in mouse models of Alzheimer's disease.15175394Zhang Y, Vilaythong AP, Yoshor D, Noebels JLThe Journal of neuroscience : the official journal of the Society for NeuroscienceElevated thalamic low-voltage-activated currents precede the onset of absence epilepsy in the SNAP25-deficient mouse mutant coloboma. J Neurosci. 2004 Jun 02; 24(22):5239-48.J Neurosci2004-06-02T00:00:002004Elevated thalamic low-voltage-activated currents precede the onset of absence epilepsy in the SNAP25-deficient mouse mutant coloboma.17982453Glasscock E, Qian J, Yoo JW, Noebels JLNature neuroscienceMasking epilepsy by combining two epilepsy genes. Nat Neurosci. 2007 Dec; 10(12):1554-8.Nat Neurosci2007-11-04T00:00:002007Masking epilepsy by combining two epilepsy genes.18215623Seal RP, Akil O, Yi E, Weber CM, Grant L, Yoo J, Clause A, Kandler K, Noebels JL, Glowatzki E, Lustig LR, Edwards RHNeuronSensorineural deafness and seizures in mice lacking vesicular glutamate transporter 3. Neuron. 2008 Jan 24; 57(2):263-75.Neuron2008-01-24T00:00:002008Sensorineural deafness and seizures in mice lacking vesicular glutamate transporter 3.15456862May P, Rohlmann A, Bock HH, Zurhove K, Marth JD, Schomburg ED, Noebels JL, Beffert U, Sweatt JD, Weeber EJ, Herz JMolecular and cellular biologyNeuronal LRP1 functionally associates with postsynaptic proteins and is required for normal motor function in mice. Mol Cell Biol. 2004 Oct; 24(20):8872-83.Mol Cell Biol2004-10-01T00:00:002004Neuronal LRP1 functionally associates with postsynaptic proteins and is required for normal motor function in mice.18769138Shuba YM, Perez-Reyes E, Lory P, Noebels JChannels (Austin, Tex.)T-type calcium channels: from discovery to channelopathies, 25 years of research. Channels (Austin). 2008 Jul-Aug; 2(4):299-302.Channels (Austin)2008-07-10T00:00:002008T-type calcium channels: from discovery to channelopathies, 25 years of research.15765140Jankovic J, Noebels JLThe Journal of clinical investigationGenetic mouse models of essential tremor: are they essential? J Clin Invest. 2005 Mar; 115(3):584-6.J Clin Invest2005-03-01T00:00:002005Genetic mouse models of essential tremor: are they essential?15857855Senechal KR, Thaller C, Noebels JLHuman molecular geneticsADPEAF mutations reduce levels of secreted LGI1, a putative tumor suppressor protein linked to epilepsy. Hum Mol Genet. 2005 Jun 15; 14(12):1613-20.Hum Mol Genet2005-04-27T00:00:002005ADPEAF mutations reduce levels of secreted LGI1, a putative tumor suppressor protein linked to epilepsy.15919713Qian J, Noebels JLThe Journal of physiologyVisualization of transmitter release with zinc fluorescence detection at the mouse hippocampal mossy fibre synapse. J Physiol. 2005 Aug 01; 566(Pt 3):747-58.J Physiol2005-05-26T00:00:002005Visualization of transmitter release with zinc fluorescence detection at the mouse hippocampal mossy fibre synapse.15351775Collins AL, Levenson JM, Vilaythong AP, Richman R, Armstrong DL, Noebels JL, David Sweatt J, Zoghbi HYHuman molecular geneticsMild overexpression of MeCP2 causes a progressive neurological disorder in mice. Hum Mol Genet. 2004 Nov 01; 13(21):2679-89.Hum Mol Genet2004-09-06T00:00:002004Mild overexpression of MeCP2 causes a progressive neurological disorder in mice.20921410Peebles CL, Yoo J, Thwin MT, Palop JJ, Noebels JL, Finkbeiner SProceedings of the National Academy of Sciences of the United States of AmericaArc regulates spine morphology and maintains network stability in vivo. Proc Natl Acad Sci U S A. 2010 Oct 19; 107(42):18173-8.Proc Natl Acad Sci U S A2010-10-04T00:00:002010Arc regulates spine morphology and maintains network stability in vivo.21208201Noebels JL, Avoli M, Rogawski M, Olsen R, Delgado-Escueta AVEpilepsia"Jasper's Basic Mechanisms of the Epilepsies" Workshop. Epilepsia. 2010 Dec; 51 Suppl 5:1-5.Epilepsia2010-12-01T00:00:002010"Jasper's Basic Mechanisms of the Epilepsies" Workshop.21209194Qian J, Xu K, Yoo J, Chen TT, Andrews G, Noebels JLThe Journal of neuroscience : the official journal of the Society for NeuroscienceKnockout of Zn transporters Zip-1 and Zip-3 attenuates seizure-induced CA1 neurodegeneration. J Neurosci. 2011 Jan 05; 31(1):97-104.J Neurosci2011-01-05T00:00:002011Knockout of Zn transporters Zip-1 and Zip-3 attenuates seizure-induced CA1 neurodegeneration.21785360McGuire AL, Oliver JM, Slashinski MJ, Graves JL, Wang T, Kelly PA, Fisher W, Lau CC, Goss J, Okcu M, Treadwell-Deering D, Goldman AM, Noebels JL, Hilsenbeck SGGenetics in medicine : official journal of the American College of Medical GeneticsTo share or not to share: a randomized trial of consent for data sharing in genome research. Genet Med. 2011 Nov; 13(11):948-55.Genet Med2011-11-01T00:00:002011To share or not to share: a randomized trial of consent for data sharing in genome research.17029973Noebels JLEpilepsy & behavior : E&BThe Judith Hoyer Lecture: genes, pixels, patterns, and prevention. Epilepsy Behav. 2006 Nov; 9(3):379-85.Epilepsy Behav2006-10-06T00:00:002006The Judith Hoyer Lecture: genes, pixels, patterns, and prevention.22560224York B, Reineke EL, Sagen JV, Nikolai BC, Zhou S, Louet JF, Chopra AR, Chen X, Reed G, Noebels J, Adesina AM, Yu H, Wong LJ, Tsimelzon A, Hilsenbeck S, Stevens RD, Wenner BR, Ilkayeva O, Xu J, Newgard CB, O'Malley BWCell metabolismAblation of steroid receptor coactivator-3 resembles the human CACT metabolic myopathy. Cell Metab. 2012 May 02; 15(5):752-63.Cell Metab2012-05-02T00:00:002012Ablation of steroid receptor coactivator-3 resembles the human CACT metabolic myopathy.22565167Olivetti PR, Noebels JLCurrent opinion in neurobiologyInterneuron, interrupted: molecular pathogenesis of ARX mutations and X-linked infantile spasms. Curr Opin Neurobiol. 2012 Oct; 22(5):859-65.Curr Opin Neurobiol2012-05-05T00:00:002012Interneuron, interrupted: molecular pathogenesis of ARX mutations and X-linked infantile spasms.22641786Glasscock E, Qian J, Kole MJ, Noebels JLThe Journal of physiologyTranscompartmental reversal of single fibre hyperexcitability in juxtaparanodal Kv1.1-deficient vagus nerve axons by activation of nodal KCNQ channels. J Physiol. 2012 Aug 15; 590(16):3913-26.J Physiol2012-05-28T00:00:002012Transcompartmental reversal of single fibre hyperexcitability in juxtaparanodal Kv1.1-deficient vagus nerve axons by activation of nodal KCNQ channels.201346Noebels JL, Prince DABrain researchPresynaptic origin of penicillin after discharges at mammalian nerve terminals. Brain Res. 1977 Dec 09; 138(1):59-74.Brain Res1977-12-09T00:00:001977Presynaptic origin of penicillin after discharges at mammalian nerve terminals.16497725Wang D, Pascual JM, Yang H, Engelstad K, Mao X, Cheng J, Yoo J, Noebels JL, De Vivo DCHuman molecular geneticsA mouse model for Glut-1 haploinsufficiency. Hum Mol Genet. 2006 Apr 01; 15(7):1169-79.Hum Mol Genet2006-02-23T00:00:002006A mouse model for Glut-1 haploinsufficiency.16566870Goldman AM, Potocki L, Walz K, Lynch JK, Glaze DG, Lupski JR, Noebels JLJournal of child neurologyEpilepsy and chromosomal rearrangements in Smith-Magenis Syndrome [del(17)(p11.2p11.2)]. J Child Neurol. 2006 Feb; 21(2):93-8.J Child Neurol2006-02-01T00:00:002006Epilepsy and chromosomal rearrangements in Smith-Magenis Syndrome [del(17)(p11.2p11.2)].1933329Qiao XX, Noebels JLBrain researchGenetic and phenotypic heterogeneity of inherited spike-wave epilepsy: two mutant gene loci with independent cerebral excitability defects. Brain Res. 1991 Jul 26; 555(1):43-50.Brain Res1991-07-26T00:00:001991Genetic and phenotypic heterogeneity of inherited spike-wave epilepsy: two mutant gene loci with independent cerebral excitability defects.16738253Qian J, Noebels JLThe Journal of neuroscience : the official journal of the Society for NeuroscienceExocytosis of vesicular zinc reveals persistent depression of neurotransmitter release during metabotropic glutamate receptor long-term depression at the hippocampal CA3-CA1 synapse. J Neurosci. 2006 May 31; 26(22):6089-95.J Neurosci2006-05-31T00:00:002006Exocytosis of vesicular zinc reveals persistent depression of neurotransmitter release during metabotropic glutamate receptor long-term depression at the hippocampal CA3-CA1 synapse.212538Noebels JL, Prince DAJournal of neurophysiologyExcitability changes in thalamocortical relay neurons during synchronous discharges in cat neocortex. J Neurophysiol. 1978 Sep; 41(5):1282-96.J Neurophysiol1978-09-01T00:00:001978Excitability changes in thalamocortical relay neurons during synchronous discharges in cat neocortex.17884088Lopez-Santiago LF, Meadows LS, Ernst SJ, Chen C, Malhotra JD, McEwen DP, Speelman A, Noebels JL, Maier SK, Lopatin AN, Isom LLJournal of molecular and cellular cardiologySodium channel Scn1b null mice exhibit prolonged QT and RR intervals. J Mol Cell Cardiol. 2007 Nov; 43(5):636-47.J Mol Cell Cardiol2007-08-10T00:00:002007Sodium channel Scn1b null mice exhibit prolonged QT and RR intervals.17517686Bi W, Yan J, Shi X, Yuva-Paylor LA, Antalffy BA, Goldman A, Yoo JW, Noebels JL, Armstrong DL, Paylor R, Lupski JRHuman molecular geneticsRai1 deficiency in mice causes learning impairment and motor dysfunction, whereas Rai1 heterozygous mice display minimal behavioral phenotypes. Hum Mol Genet. 2007 Aug 01; 16(15):1802-13.Hum Mol Genet2007-05-21T00:00:002007Rai1 deficiency in mice causes learning impairment and motor dysfunction, whereas Rai1 heterozygous mice display minimal behavioral phenotypes.2052555Helekar SA, Noebels JLProceedings of the National Academy of Sciences of the United States of AmericaSynchronous hippocampal bursting reveals network excitability defects in an epilepsy gene mutation. Proc Natl Acad Sci U S A. 1991 Jun 01; 88(11):4736-40.Proc Natl Acad Sci U S A1991-06-01T00:00:001991Synchronous hippocampal bursting reveals network excitability defects in an epilepsy gene mutation.18988673Ernst SJ, Aguilar-Bryan L, Noebels JLEndocrinologySodium channel beta1 regulatory subunit deficiency reduces pancreatic islet glucose-stimulated insulin and glucagon secretion. Endocrinology. 2009 Mar; 150(3):1132-9.Endocrinology2008-11-06T00:00:002008Sodium channel beta1 regulatory subunit deficiency reduces pancreatic islet glucose-stimulated insulin and glucagon secretion.19480703Ernst WL, Noebels JLBMC molecular biologyExpanded alternative splice isoform profiling of the mouse Cav3.1/alpha1G T-type calcium channel. BMC Mol Biol. 2009 May 29; 10:53.BMC Mol Biol2009-05-29T00:00:002009Expanded alternative splice isoform profiling of the mouse Cav3.1/alpha1G T-type calcium channel.19341977Jacobs MP, Leblanc GG, Brooks-Kayal A, Jensen FE, Lowenstein DH, Noebels JL, Spencer DD, Swann JWEpilepsy & behavior : E&BCuring epilepsy: progress and future directions. Epilepsy Behav. 2009 Mar; 14(3):438-45.Epilepsy Behav2009-03-01T00:00:002009Curing epilepsy: progress and future directions.19587282Price MG, Yoo JW, Burgess DL, Deng F, Hrachovy RA, Frost JD, Noebels JLThe Journal of neuroscience : the official journal of the Society for NeuroscienceA triplet repeat expansion genetic mouse model of infantile spasms syndrome, Arx(GCG)10+7, with interneuronopathy, spasms in infancy, persistent seizures, and adult cognitive and behavioral impairment. J Neurosci. 2009 Jul 08; 29(27):8752-63.J Neurosci2009-07-08T00:00:002009A triplet repeat expansion genetic mouse model of infantile spasms syndrome, Arx(GCG)10+7, with interneuronopathy, spasms in infancy, persistent seizures, and adult cognitive and behavioral impairment.Authorship 6515091Authorship 6515101Authorship 6515991Authorship 6516001Authorship 6540316Authorship 654231815309062Noebels JLEpilepsy currentsStiff Goats, Chloride Ions, and Idiopathic Generalized Epilepsy (IGE). Epilepsy Curr. 2003 Jul; 3(4):146-147.Epilepsy Curr2003-07-01T00:00:002003Stiff Goats, Chloride Ions, and Idiopathic Generalized Epilepsy (IGE).15309091Noebels JLEpilepsy currentsHow a Sodium Channel Mutation Causes Epilepsy. Epilepsy Curr. 2003 Mar; 3(2):70-71.Epilepsy Curr2003-03-01T00:00:002003How a Sodium Channel Mutation Causes Epilepsy.15309143Noebels JLEpilepsy currentsA Gene for JME at Last: The alpha1 GABA Receptor Subunit. 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PLoS One. 2016; 11(11):e0167264.PLoS One2016-11-21T00:00:002016Correction: Deleterious Rare Variants Reveal Risk for Loss of GABAA Receptor Function in Patients with Genetic Epilepsy and in the General Population.27956739Lopez AY, Wang X, Xu M, Maheshwari A, Curry D, Lam S, Adesina AM, Noebels JL, Sun QQ, Cooper ECMolecular psychiatryAnkyrin-G isoform imbalance and interneuronopathy link epilepsy and bipolar disorder. Mol Psychiatry. 2017 10; 22(10):1464-1472.Mol Psychiatry2016-12-13T00:00:002016Ankyrin-G isoform imbalance and interneuronopathy link epilepsy and bipolar disorder.Authorship 6547801828106060Tang M, Gao G, Rueda CB, Yu H, Thibodeaux DN, Awano T, Engelstad KM, Sanchez-Quintero MJ, Yang H, Li F, Li H, Su Q, Shetler KE, Jones L, Seo R, McConathy J, Hillman EM, Noebels JL, De Vivo DC, Monani URNature communicationsBrain microvasculature defects and Glut1 deficiency syndrome averted by early repletion of the glucose transporter-1 protein. Nat Commun. 2017 01 20; 8:14152.Nat Commun2017-01-20T00:00:002017Brain microvasculature defects and Glut1 deficiency syndrome averted by early repletion of the glucose transporter-1 protein.2289471Noebels JL, Qiao X, Bronson RT, Spencer C, Davisson MTEpilepsy researchStargazer: a new neurological mutant on chromosome 15 in the mouse with prolonged cortical seizures. Epilepsy Res. 1990 Nov; 7(2):129-35.Epilepsy Res1990-11-01T00:00:001990Stargazer: a new neurological mutant on chromosome 15 in the mouse with prolonged cortical seizures.2292005Noebels JL, Rutecki PABrain researchAltered hippocampal network excitability in the hypernoradrenergic mutant mouse tottering. Brain Res. 1990 Aug 06; 524(2):225-30.Brain Res1990-08-06T00:00:001990Altered hippocampal network excitability in the hypernoradrenergic mutant mouse tottering.20368164Goldman AM, Glasscock E, Yoo J, Chen TT, Klassen TL, Noebels JLScience translational medicineArrhythmia in heart and brain: KCNQ1 mutations link epilepsy and sudden unexplained death. Sci Transl Med. 2009 Oct 14; 1(2):2ra6.Sci Transl Med2009-10-14T00:00:002009Arrhythmia in heart and brain: KCNQ1 mutations link epilepsy and sudden unexplained death.20808828Jiang YH, Pan Y, Zhu L, Landa L, Yoo J, Spencer C, Lorenzo I, Brilliant M, Noebels J, Beaudet ALPloS oneAltered ultrasonic vocalization and impaired learning and memory in Angelman syndrome mouse model with a large maternal deletion from Ube3a to Gabrb3. PLoS One. 2010 Aug 20; 5(8):e12278.PLoS One2010-08-20T00:00:002010Altered ultrasonic vocalization and impaired learning and memory in Angelman syndrome mouse model with a large maternal deletion from Ube3a to Gabrb3.20392939Glasscock E, Yoo JW, Chen TT, Klassen TL, Noebels JLThe Journal of neuroscience : the official journal of the Society for NeuroscienceKv1.1 potassium channel deficiency reveals brain-driven cardiac dysfunction as a candidate mechanism for sudden unexplained death in epilepsy. J Neurosci. 2010 Apr 14; 30(15):5167-75.J Neurosci2010-04-14T00:00:002010Kv1.1 potassium channel deficiency reveals brain-driven cardiac dysfunction as a candidate mechanism for sudden unexplained death in epilepsy.Authorship 7021871521068835Chao HT, Chen H, Samaco RC, Xue M, Chahrour M, Yoo J, Neul JL, Gong S, Lu HC, Heintz N, Ekker M, Rubenstein JL, Noebels JL, Rosenmund C, Zoghbi HYNatureDysfunction in GABA signalling mediates autism-like stereotypies and Rett syndrome phenotypes. Nature. 2010 Nov 11; 468(7321):263-9.Nature2010-11-11T00:00:002010Dysfunction in GABA signalling mediates autism-like stereotypies and Rett syndrome phenotypes.28166219John Lin CC, Yu K, Hatcher A, Huang TW, Lee HK, Carlson J, Weston MC, Chen F, Zhang Y, Zhu W, Mohila CA, Ahmed N, Patel AJ, Arenkiel BR, Noebels JL, Creighton CJ, Deneen BNature neuroscienceIdentification of diverse astrocyte populations and their malignant analogs. Nat Neurosci. 2017 Mar; 20(3):396-405.Nat Neurosci2017-02-06T00:00:002017Identification of diverse astrocyte populations and their malignant analogs.21214538Noebels JEpilepsiaA perfect storm: Converging paths of epilepsy and Alzheimer's dementia intersect in the hippocampal formation. Epilepsia. 2011 Jan; 52 Suppl 1:39-46.Epilepsia2011-01-01T00:00:002011A perfect storm: Converging paths of epilepsy and Alzheimer's dementia intersect in the hippocampal formation.21228179Roberson ED, Halabisky B, Yoo JW, Yao J, Chin J, Yan F, Wu T, Hamto P, Devidze N, Yu GQ, Palop JJ, Noebels JL, Mucke LThe Journal of neuroscience : the official journal of the Society for NeuroscienceAmyloid-?/Fyn-induced synaptic, network, and cognitive impairments depend on tau levels in multiple mouse models of Alzheimer's disease. J Neurosci. 2011 Jan 12; 31(2):700-11.J Neurosci2011-01-12T00:00:002011Amyloid-?/Fyn-induced synaptic, network, and cognitive impairments depend on tau levels in multiple mouse models of Alzheimer's disease.21411672Mark MD, Maejima T, Kuckelsberg D, Yoo JW, Hyde RA, Shah V, Gutierrez D, Moreno RL, Kruse W, Noebels JL, Herlitze SThe Journal of neuroscience : the official journal of the Society for NeuroscienceDelayed postnatal loss of P/Q-type calcium channels recapitulates the absence epilepsy, dyskinesia, and ataxia phenotypes of genomic Cacna1a mutations. J Neurosci. 2011 Mar 16; 31(11):4311-26.J Neurosci2011-03-16T00:00:002011Delayed postnatal loss of P/Q-type calcium channels recapitulates the absence epilepsy, dyskinesia, and ataxia phenotypes of genomic Cacna1a mutations.21543734Hirsch LJ, Donner EJ, So EL, Jacobs M, Nashef L, Noebels JL, Buchhalter JRNeurologyAbbreviated report of the NIH/NINDS workshop on sudden unexpected death in epilepsy. Neurology. 2011 May 31; 76(22):1932-8.Neurology2011-05-04T00:00:002011Abbreviated report of the NIH/NINDS workshop on sudden unexpected death in epilepsy.21753013Ward CS, Arvide EM, Huang TW, Yoo J, Noebels JL, Neul JLThe Journal of neuroscience : the official journal of the Society for NeuroscienceMeCP2 is critical within HoxB1-derived tissues of mice for normal lifespan. J Neurosci. 2011 Jul 13; 31(28):10359-70.J Neurosci2011-07-13T00:00:002011MeCP2 is critical within HoxB1-derived tissues of mice for normal lifespan.22292566Galanopoulou AS, Buckmaster PS, Staley KJ, Mosh? SL, Perucca E, Engel J, L?scher W, Noebels JL, Pitk?nen A, Stables J, White HS, O'Brien TJ, Simonato M, American Epilepsy Society Basic Science Committee And The International League Against Epilepsy WorkEpilepsiaIdentification of new epilepsy treatments: issues in preclinical methodology. Epilepsia. 2012 Mar; 53(3):571-82.Epilepsia2012-01-31T00:00:002012Identification of new epilepsy treatments: issues in preclinical methodology.22578186de Curtis M, Nehlig A, Noebels J, Sankar R, Vezzani AEpilepsiaWONOEP XI: Workshop summary by the Scientific Organizing Committee. Epilepsia. 2012 Jul; 53(7):1275-6.Epilepsia2012-05-11T00:00:002012WONOEP XI: Workshop summary by the Scientific Organizing Committee.23090947Lerche H, Shah M, Beck H, Noebels J, Johnston D, Vincent AThe Journal of physiologyIon channels in genetic and acquired forms of epilepsy. J Physiol. 2013 Feb 15; 591(4):753-64.J Physiol2012-10-22T00:00:002012Ion channels in genetic and acquired forms of epilepsy.22153080Zhu PJ, Huang W, Kalikulov D, Yoo JW, Placzek AN, Stoica L, Zhou H, Bell JC, Friedlander MJ, Krnjevic K, Noebels JL, Costa-Mattioli MCellSuppression of PKR promotes network excitability and enhanced cognition by interferon-?-mediated disinhibition. Cell. 2011 Dec 09; 147(6):1384-96.Cell2011-12-09T00:00:002011Suppression of PKR promotes network excitability and enhanced cognition by interferon-?-mediated disinhibition.22796560Klassen TL, von R?den EL, Drabek J, Noebels JL, Goldman AMThe Journal of molecular diagnostics : JMDComparative analytical utility of DNA derived from alternative human specimens for molecular autopsy and diagnostics. J Mol Diagn. 2012 Sep; 14(5):451-7.J Mol Diagn2012-07-13T00:00:002012Comparative analytical utility of DNA derived from alternative human specimens for molecular autopsy and diagnostics.23345237Holth JK, Bomben VC, Reed JG, Inoue T, Younkin L, Younkin SG, Pautler RG, Botas J, Noebels JLThe Journal of neuroscience : the official journal of the Society for NeuroscienceTau loss attenuates neuronal network hyperexcitability in mouse and Drosophila genetic models of epilepsy. J Neurosci. 2013 Jan 23; 33(4):1651-9.J Neurosci2013-01-23T00:00:002013Tau loss attenuates neuronal network hyperexcitability in mouse and Drosophila genetic models of epilepsy.23359859Eom T, Zhang C, Wang H, Lay K, Fak J, Noebels JL, Darnell RBeLifeNOVA-dependent regulation of cryptic NMD exons controls synaptic protein levels after seizure. Elife. 2013 Jan 22; 2:e00178.Elife2013-01-22T00:00:002013NOVA-dependent regulation of cryptic NMD exons controls synaptic protein levels after seizure.23516282Maejima T, Wollenweber P, Teusner LU, Noebels JL, Herlitze S, Mark MDThe Journal of neuroscience : the official journal of the Society for NeurosciencePostnatal loss of P/Q-type channels confined to rhombic-lip-derived neurons alters synaptic transmission at the parallel fiber to purkinje cell synapse and replicates genomic Cacna1a mutation phenotype of ataxia and seizures in mice. J Neurosci. 2013 Mar 20; 33(12):5162-74.J Neurosci2013-03-20T00:00:002013Postnatal loss of P/Q-type channels confined to rhombic-lip-derived neurons alters synaptic transmission at the parallel fiber to purkinje cell synapse and replicates genomic Cacna1a mutation phenotype of ataxia and seizures in mice.2778559Noebels JL, Sidman RLJournal of neurogeneticsPersistent hypersynchronization of neocortical neurons in the mocha mutant of mouse. J Neurogenet. 1989 Sep; 6(1):53-6.J Neurogenet1989-09-01T00:00:001989Persistent hypersynchronization of neocortical neurons in the mocha mutant of mouse.383515Noebels JLFederation proceedingsAnalysis of inherited epilepsy using single locus mutations in mice. Fed Proc. 1979 Sep; 38(10):2405-10.Fed Proc1979-09-01T00:00:001979Analysis of inherited epilepsy using single locus mutations in mice.Authorship 869179128428202Noebels JThe Journal of general physiologyPrecision physiology and rescue of brain ion channel disorders. J Gen Physiol. 2017 May 01; 149(5):533-546.J Gen Physiol2017-04-20T00:00:002017Precision physiology and rescue of brain ion channel disorders.572084Noebels JL, Sidman RLScience (New York, N.Y.)Inherited epilepsy: spike-wave and focal motor seizures in the mutant mouse tottering. Science. 1979 Jun 22; 204(4399):1334-6.Science1979-06-22T00:00:001979Inherited epilepsy: spike-wave and focal motor seizures in the mutant mouse tottering.Authorship 10277026095738Noebels JLAnnals of neurologyIsolating single genes of the inherited epilepsies. Ann Neurol. 1984; 16 Suppl:S18-21.Ann Neurol1984-01-01T00:00:001984Isolating single genes of the inherited epilepsies.6462226Noebels JLNatureA single gene error of noradrenergic axon growth synchronizes central neurones. Nature. 1984 Aug 2-8; 310(5976):409-11.Nature1984-08-01T00:00:001984A single gene error of noradrenergic axon growth synchronizes central neurones.6945603Levitt P, Noebels JLProceedings of the National Academy of Sciences of the United States of AmericaMutant mouse tottering: selective increase of locus ceruleus axons in a defined single-locus mutation. Proc Natl Acad Sci U S A. 1981 Jul; 78(7):4630-4.Proc Natl Acad Sci U S A1981-07-01T00:00:001981Mutant mouse tottering: selective increase of locus ceruleus axons in a defined single-locus mutation.7642343Noebels JLItalian journal of neurological sciencesSingle locus mutations in mice expressing generalized spike-wave absence epilepsies. Ital J Neurol Sci. 1995 Feb-Mar; 16(1-2):107-11.Ital J Neurol Sci1995-02-01T00:00:001995Single locus mutations in mice expressing generalized spike-wave absence epilepsies.8229188Qiao X, Noebels JLThe Journal of neuroscience : the official journal of the Society for NeuroscienceDevelopmental analysis of hippocampal mossy fiber outgrowth in a mutant mouse with inherited spike-wave seizures. J Neurosci. 1993 Nov; 13(11):4622-35.J Neurosci1993-11-01T00:00:001993Developmental analysis of hippocampal mossy fiber outgrowth in a mutant mouse with inherited spike-wave seizures.8551348Qiao X, Hefti F, Knusel B, Noebels JLThe Journal of neuroscience : the official journal of the Society for NeuroscienceSelective failure of brain-derived neurotrophic factor mRNA expression in the cerebellum of stargazer, a mutant mouse with ataxia. J Neurosci. 1996 Jan 15; 16(2):640-8.J Neurosci1996-01-15T00:00:001996Selective failure of brain-derived neurotrophic factor mRNA expression in the cerebellum of stargazer, a mutant mouse with ataxia.Authorship 10266699039265Burgess DL, Jones JM, Meisler MH, Noebels JLCellMutation of the Ca2+ channel beta subunit gene Cchb4 is associated with ataxia and seizures in the lethargic (lh) mouse. Cell. 1997 Feb 07; 88(3):385-92.Cell1997-02-07T00:00:001997Mutation of the Ca2+ channel beta subunit gene Cchb4 is associated with ataxia and seizures in the lethargic (lh) mouse.9391152Kash SF, Johnson RS, Tecott LH, Noebels JL, Mayfield RD, Hanahan D, Baekkeskov SProceedings of the National Academy of Sciences of the United States of AmericaEpilepsy in mice deficient in the 65-kDa isoform of glutamic acid decarboxylase. Proc Natl Acad Sci U S A. 1997 Dec 09; 94(25):14060-5.Proc Natl Acad Sci U S A1997-12-09T00:00:001997Epilepsy in mice deficient in the 65-kDa isoform of glutamic acid decarboxylase.Authorship 869985528459436Lam AD, Deck G, Goldman A, Eskandar EN, Noebels J, Cole AJNature medicineSilent hippocampal seizures and spikes identified by foramen ovale electrodes in Alzheimer's disease. Nat Med. 2017 Jun; 23(6):678-680.Nat Med2017-05-01T00:00:002017Silent hippocampal seizures and spikes identified by foramen ovale electrodes in Alzheimer's disease.9801364Nahm WK, Noebels JLThe Journal of neuroscience : the official journal of the Society for NeuroscienceNonobligate role of early or sustained expression of immediate-early gene proteins c-fos, c-jun, and Zif/268 in hippocampal mossy fiber sprouting. J Neurosci. 1998 Nov 15; 18(22):9245-55.J Neurosci1998-11-15T00:00:001998Nonobligate role of early or sustained expression of immediate-early gene proteins c-fos, c-jun, and Zif/268 in hippocampal mossy fiber sprouting.10515159Burgess DL, Noebels JLEpilepsy researchSingle gene defects in mice: the role of voltage-dependent calcium channels in absence models. Epilepsy Res. 1999 Sep; 36(2-3):111-22.Epilepsy Res1999-09-01T00:00:001999Single gene defects in mice: the role of voltage-dependent calcium channels in absence models.10670432Ayata C, Shimizu-Sasamata M, Lo EH, Noebels JL, Moskowitz MANeuroscienceImpaired neurotransmitter release and elevated threshold for cortical spreading depression in mice with mutations in the alpha1A subunit of P/Q type calcium channels. Neuroscience. 2000; 95(3):639-45.Neuroscience2000-01-01T00:00:002000Impaired neurotransmitter release and elevated threshold for cortical spreading depression in mice with mutations in the alpha1A subunit of P/Q type calcium channels.11017075Matsuura T, Yamagata T, Burgess DL, Rasmussen A, Grewal RP, Watase K, Khajavi M, McCall AE, Davis CF, Zu L, Achari M, Pulst SM, Alonso E, Noebels JL, Nelson DL, Zoghbi HY, Ashizawa TNature geneticsLarge expansion of the ATTCT pentanucleotide repeat in spinocerebellar ataxia type 10. Nat Genet. 2000 Oct; 26(2):191-4.Nat Genet2000-10-01T00:00:002000Large expansion of the ATTCT pentanucleotide repeat in spinocerebellar ataxia type 10.11887961Noebels JLEpilepsiaModeling human epilepsies in mice. Epilepsia. 2001; 42 Suppl 5:11-5.Epilepsia2001-01-01T00:00:002001Modeling human epilepsies in mice.12151514Zhang Y, Mori M, Burgess DL, Noebels JLThe Journal of neuroscience : the official journal of the Society for NeuroscienceMutations in high-voltage-activated calcium channel genes stimulate low-voltage-activated currents in mouse thalamic relay neurons. J Neurosci. 2002 Aug 01; 22(15):6362-71.J Neurosci2002-08-01T00:00:002002Mutations in high-voltage-activated calcium channel genes stimulate low-voltage-activated currents in mouse thalamic relay neurons.12647238Kantheti P, Diaz ME, Peden AE, Seong EE, Dolan DF, Robinson MS, Noebels JL, Burmeister MLMammalian genome : official journal of the International Mammalian Genome SocietyGenetic and phenotypic analysis of the mouse mutant mh2J, an Ap3d allele caused by IAP element insertion. Mamm Genome. 2003 Mar; 14(3):157-67.Mamm Genome2003-03-01T00:00:002003Genetic and phenotypic analysis of the mouse mutant mh2J, an Ap3d allele caused by IAP element insertion.12724422Walz K, Caratini-Rivera S, Bi W, Fonseca P, Mansouri DL, Lynch J, Vogel H, Noebels JL, Bradley A, Lupski JRMolecular and cellular biologyModeling del(17)(p11.2p11.2) and dup(17)(p11.2p11.2) contiguous gene syndromes by chromosome engineering in mice: phenotypic consequences of gene dosage imbalance. Mol Cell Biol. 2003 May; 23(10):3646-55.Mol Cell Biol2003-05-01T00:00:002003Modeling del(17)(p11.2p11.2) and dup(17)(p11.2p11.2) contiguous gene syndromes by chromosome engineering in mice: phenotypic consequences of gene dosage imbalance.12752457Noebels JLEpilepsiaExploring new gene discoveries in idiopathic generalized epilepsy. Epilepsia. 2003; 44 Suppl 2:16-21.Epilepsia2003-01-01T00:00:002003Exploring new gene discoveries in idiopathic generalized epilepsy.12918016Houseweart MK, Pennacchio LA, Vilaythong A, Peters C, Noebels JL, Myers RMJournal of neurobiologyCathepsin B but not cathepsins L or S contributes to the pathogenesis of Unverricht-Lundborg progressive myoclonus epilepsy (EPM1). J Neurobiol. 2003 Sep 15; 56(4):315-27.J Neurobiol2003-09-15T00:00:002003Cathepsin B but not cathepsins L or S contributes to the pathogenesis of Unverricht-Lundborg progressive myoclonus epilepsy (EPM1).12934064Houseweart MK, Vilaythong A, Yin XM, Turk B, Noebels JL, Myers RMCell death and differentiationApoptosis caused by cathepsins does not require Bid signaling in an in vivo model of progressive myoclonus epilepsy (EPM1). Cell Death Differ. 2003 Dec; 10(12):1329-35.Cell Death Differ2003-12-01T00:00:002003Apoptosis caused by cathepsins does not require Bid signaling in an in vivo model of progressive myoclonus epilepsy (EPM1).Authorship 10453151713650Noebels JL, Marcom PK, Jalilian-Tehrani MHNatureSodium channel density in hypomyelinated brain increased by myelin basic protein gene deletion. Nature. 1991 Aug 01; 352(6334):431-4.Nature1991-08-01T00:00:001991Sodium channel density in hypomyelinated brain increased by myelin basic protein gene deletion.15286683Mori M, Burgess DL, Gefrides LA, Foreman PJ, Opferman JT, Korsmeyer SJ, Cavalheiro EA, Naffah-Mazzacoratti MG, Noebels JLCell death and differentiationExpression of apoptosis inhibitor protein Mcl1 linked to neuroprotection in CNS neurons. Cell Death Differ. 2004 Nov; 11(11):1223-33.Cell Death Differ2004-11-01T00:00:002004Expression of apoptosis inhibitor protein Mcl1 linked to neuroprotection in CNS neurons.1815603Noebels JLEpilepsy research. SupplementMutational analysis of spike-wave epilepsy phenotypes. Epilepsy Res Suppl. 1991; 4:201-12.Epilepsy Res Suppl1991-01-01T00:00:001991Mutational analysis of spike-wave epilepsy phenotypes.17054704Goldman A, Noebels JEpilepsiaInvited comments on the Shostak and Ottman review. Epilepsia. 2006 Oct; 47(10):1750-1; author reply 1755-6.Epilepsia2006-10-01T00:00:002006Invited comments on the Shostak and Ottman review.17525034Sisodiya S, Cross JH, Bl?mcke I, Chadwick D, Craig J, Crino PB, Debenham P, Delanty N, Elmslie F, Gardiner M, Golden J, Goldstein D, Greenberg DA, Guerrini R, Hanna M, Harris J, Harrison P, Johnson MR, Kirov G, Kullman DM, Makoff A, Marini C, Nabbout R, Nashef L, Noebels JL, Ottman R, Pirmohamed M, Pitk?nen A, Scheffer I, Shorvon S, Sills G, Wood N, Zuberi SEpileptic disorders : international epilepsy journal with videotapeGenetics of epilepsy: epilepsy research foundation workshop report. Epileptic Disord. 2007 Jun; 9(2):194-236.Epileptic Disord2007-06-01T00:00:002007Genetics of epilepsy: epilepsy research foundation workshop report.18161587Noebels JL, Sidman RLJournal of neurogeneticsPersistent hypersynchronization of neocortical neurons in the mocha mutant of mouse. J Neurogenet. 2007 Oct-Dec; 21(4):253-6.J Neurogenet2007-10-01T00:00:002007Persistent hypersynchronization of neocortical neurons in the mocha mutant of mouse.18304250Noebels JLEpilepsia2006 Merritt Putnam Symposium: mapping epileptic circuitry. Epilepsia. 2008; 49 Suppl 3:1-2.Epilepsia2008-01-01T00:00:0020082006 Merritt Putnam Symposium: mapping epileptic circuitry.18483067Singh NA, Otto JF, Dahle EJ, Pappas C, Leslie JD, Vilaythong A, Noebels JL, White HS, Wilcox KS, Leppert MFThe Journal of physiologyMouse models of human KCNQ2 and KCNQ3 mutations for benign familial neonatal convulsions show seizures and neuronal plasticity without synaptic reorganization. J Physiol. 2008 Jul 15; 586(14):3405-23.J Physiol2008-05-15T00:00:002008Mouse models of human KCNQ2 and KCNQ3 mutations for benign familial neonatal convulsions show seizures and neuronal plasticity without synaptic reorganization.19211869Ernst WL, Zhang Y, Yoo JW, Ernst SJ, Noebels JLThe Journal of neuroscience : the official journal of the Society for NeuroscienceGenetic enhancement of thalamocortical network activity by elevating alpha 1g-mediated low-voltage-activated calcium current induces pure absence epilepsy. J Neurosci. 2009 Feb 11; 29(6):1615-25.J Neurosci2009-02-11T00:00:002009Genetic enhancement of thalamocortical network activity by elevating alpha 1g-mediated low-voltage-activated calcium current induces pure absence epilepsy.20100225Ottman R, Hirose S, Jain S, Lerche H, Lopes-Cendes I, Noebels JL, Serratosa J, Zara F, Scheffer IEEpilepsiaGenetic testing in the epilepsies--report of the ILAE Genetics Commission. Epilepsia. 2010 Apr; 51(4):655-70.Epilepsia2010-01-19T00:00:002010Genetic testing in the epilepsies--report of the ILAE Genetics Commission.20676103Zhang X, Bertaso F, Yoo JW, Baumg?rtel K, Clancy SM, Lee V, Cienfuegos C, Wilmot C, Avis J, Hunyh T, Daguia C, Schmedt C, Noebels J, Jegla TNature neuroscienceDeletion of the potassium channel Kv12.2 causes hippocampal hyperexcitability and epilepsy. Nat Neurosci. 2010 Sep; 13(9):1056-8.Nat Neurosci2010-08-01T00:00:002010Deletion of the potassium channel Kv12.2 causes hippocampal hyperexcitability and epilepsy.Authorship 1046621421663635Shim DJ, Yang L, Reed JG, Noebels JL, Chiao PJ, Zheng HMolecular neurodegenerationDisruption of the NF-?B/I?Ba Autoinhibitory Loop Improves Cognitive Performance and Promotes Hyperexcitability of Hippocampal Neurons. Mol Neurodegener. 2011 Jun 10; 6:42.Mol Neurodegener2011-06-10T00:00:002011Disruption of the NF-?B/I?Ba Autoinhibitory Loop Improves Cognitive Performance and Promotes Hyperexcitability of Hippocampal Neurons.21703448Klassen T, Davis C, Goldman A, Burgess D, Chen T, Wheeler D, McPherson J, Bourquin T, Lewis L, Villasana D, Morgan M, Muzny D, Gibbs R, Noebels JCellExome sequencing of ion channel genes reveals complex profiles confounding personal risk assessment in epilepsy. Cell. 2011 Jun 24; 145(7):1036-48.Cell2011-06-24T00:00:002011Exome sequencing of ion channel genes reveals complex profiles confounding personal risk assessment in epilepsy.22998874Ince-Dunn G, Okano HJ, Jensen KB, Park WY, Zhong R, Ule J, Mele A, Fak JJ, Yang C, Zhang C, Yoo J, Herre M, Okano H, Noebels JL, Darnell RBNeuronNeuronal Elav-like (Hu) proteins regulate RNA splicing and abundance to control glutamate levels and neuronal excitability. Neuron. 2012 Sep 20; 75(6):1067-80.Neuron2012-09-20T00:00:002012Neuronal Elav-like (Hu) proteins regulate RNA splicing and abundance to control glutamate levels and neuronal excitability.Authorship 8792387Authorship 8797628Authorship 880085629038240Huang CY, Zhang C, Ho TS, Oses-Prieto J, Burlingame AL, Lalonde J, Noebels JL, Leterrier C, Rasband MNThe Journal of neuroscience : the official journal of the Society for NeuroscienceaII Spectrin Forms a Periodic Cytoskeleton at the Axon Initial Segment and Is Required for Nervous System Function. J Neurosci. 2017 11 22; 37(47):11311-11322.J Neurosci2017-10-16T00:00:002017aII Spectrin Forms a Periodic Cytoskeleton at the Axon Initial Segment and Is Required for Nervous System Function.28901011Maheshwari A, Akbar A, Wang M, Marks RL, Yu K, Park S, Foster BL, Noebels JLThe Journal of physiologyPersistent aberrant cortical phase-amplitude coupling following seizure treatment in absence epilepsy models. J Physiol. 2017 12 01; 595(23):7249-7260.J Physiol2017-09-19T00:00:002017Persistent aberrant cortical phase-amplitude coupling following seizure treatment in absence epilepsy models.29105070Moyer JT, Gnatkovsky V, Ono T, Ot?hal J, Wagenaar J, Stacey WC, Noebels J, Ikeda A, Staley K, de Curtis M, Litt B, Galanopoulou ASEpilepsiaStandards for data acquisition and software-based analysis of in?vivo electroencephalography recordings from animals. A TASK1-WG5 report of the AES/ILAE Translational Task Force of the ILAE. Epilepsia. 2017 11; 58 Suppl 4:53-67.Epilepsia2017-11-01T00:00:002017Standards for data acquisition and software-based analysis of in?vivo electroencephalography recordings from animals. A TASK1-WG5 report of the AES/ILAE Translational Task Force of the ILAE.23408874Chen TT, Klassen TL, Goldman AM, Marini C, Guerrini R, Noebels JLNeurologyNovel brain expression of ClC-1 chloride channels and enrichment of CLCN1 variants in epilepsy. Neurology. 2013 Mar 19; 80(12):1078-85.Neurology2013-02-13T00:00:002013Novel brain expression of ClC-1 chloride channels and enrichment of CLCN1 variants in epilepsy.23518217Klassen TL, Drabek J, Tomson T, Sveinsson O, von D?beln U, Noebels JL, Goldman AMThe Journal of molecular diagnostics : JMDVisual automated fluorescence electrophoresis provides simultaneous quality, quantity, and molecular weight spectra for genomic DNA from archived neonatal blood spots. J Mol Diagn. 2013 May; 15(3):283-90.J Mol Diagn2013-03-19T00:00:002013Visual automated fluorescence electrophoresis provides simultaneous quality, quantity, and molecular weight spectra for genomic DNA from archived neonatal blood spots.23758236Cole AJ, Eskandar E, Mela T, Noebels JL, Gonzalez RG, McGuone DThe New England journal of medicineCase records of the Massachusetts General Hospital. Case 18-2013: a 32-year-old woman with recurrent episodes of altered consciousness. N Engl J Med. 2013 Jun 13; 368(24):2304-12.N Engl J Med2013-06-13T00:00:002013Case records of the Massachusetts General Hospital. Case 18-2013: a 32-year-old woman with recurrent episodes of altered consciousness.2ProfessorProfessortrue1ProfessorProfessortrue1ProfessorProfessortrue1ProfessorProfessor3ProfessorProfessortrue1Associate ProfessorAssociate Professortrue1Distinguished Service ProfessorDistinguished Service ProfessorAuthorship 1023676Authorship 1025461D004832Disorders13350.948759Epilepsy, AbsenceD015220Chemicals & Drugs931960.88398Calcium ChannelsD003645Disorders46590.946872Death, SuddenD004827Disorders2568730.550536EpilepsyAuthorship 1095337Authorship 91651918Authorship 9297883Authorship 9302556Authorship 938790230128323Chen C, Holth JK, Bunton-Stasyshyn R, Anumonwo CK, Meisler MH, Noebels JL, Isom LLAnnals of clinical and translational neurologyMapt deletion fails to rescue premature lethality in two models of sodium channel epilepsy. Ann Clin Transl Neurol. 2018 Aug; 5(8):982-987.Ann Clin Transl Neurol2018-07-05T00:00:002018Mapt deletion fails to rescue premature lethality in two models of sodium channel epilepsy.30175250Ogiwara I, Miyamoto H, Tatsukawa T, Yamagata T, Nakayama T, Atapour N, Miura E, Mazaki E, Ernst SJ, Cao D, Ohtani H, Itohara S, Yanagawa Y, Montal M, Yuzaki M, Inoue Y, Hensch TK, Noebels JL, Yamakawa KCommunications biologyNav1.2 haplodeficiency in excitatory neurons causes absence-like seizures in mice. Commun Biol. 2018; 1:96.Commun Biol2018-07-19T00:00:002018Nav1.2 haplodeficiency in excitatory neurons causes absence-like seizures in mice.29769525Meyer J, Maheshwari A, Noebels J, Smirnakis SNature communicationsAsynchronous suppression of visual cortex during absence seizures in stargazer mice. Nat Commun. 2018 05 16; 9(1):1938.Nat Commun2018-05-16T00:00:002018Asynchronous suppression of visual cortex during absence seizures in stargazer mice.30699052Aiba I, Noebels JLJournal of neurophysiologyAdrenergic agonist induces rhythmic firing in quiescent cardiac preganglionic neurons in nucleus ambiguous via activation of intrinsic membrane excitability. J Neurophysiol. 2019 04 01; 121(4):1266-1278.J Neurophysiol2019-01-30T00:00:002019Adrenergic agonist induces rhythmic firing in quiescent cardiac preganglionic neurons in nucleus ambiguous via activation of intrinsic membrane excitability.Authorship 10490810D012640Disorders3999790.636017Seizures2008-08-31NIHNOEBELS, JEFFREY2005-09-30Course Development in the Neurobiology of DiseaseR25MH0767642023-11-30NIHDENEEN, BENJAMIN ;NOEBELS, JEFFREY2017-12-15MOLECULAR DISSECTION OF SEIZURE MICROENVIRONMENT IN MALIGNANT GLIOMAR01CA2233882021-07-31NIHLHATOO, SAMDEN2014-09-30The Administrative Core of the Center of SUDEP ResearchU01NS0904052020-07-31NIHNOEBELS, JEFFREY2014-09-30SUDEP Research Alliance: Cardiac Gene and Circuit Mechanisms; Application 7 of 7U01NS0903402004-06-30NIHNOEBELS, JEFFREY1999-09-30NEUROPHYSIOLOGY DATABASE OF INBRED MUTANT STRAINSR01NS0402332019-09-29NIHNOEBELS, JEFFREY2018-09-30Jasper's Basic Mechanisms of the Epilepsies WorkshopsR13NS1103082010-05-31NIHNOEBELS, JEFFREY2004-08-15Parallel Sequence Profiling of Ion Channels in EpilepsyR01NS0491302017-01-31NIHGARDEN, GWENN A2006-05-01Neurobiology of Disease Workshop -- Teaching WorkshopR25NS0547672014-08-31NIHNOEBELS, JEFFREY2011-09-26PREDICTIVE GENES, MECHANISMS, AND CLINICAL BIOMARKERS OF SUDEPP20NS0769162018-04-30NIHNOEBELS, JEFFREY2015-05-01In vivo recruitment of neocortical neurons in stargazer absence seizuresR21NS0884572026-05-31NIHNOEBELS, JEFFREY1991-09-01Excitability and Plasticity of Developing Epileptic BrainR01NS029709Principal InvestigatorPrincipal InvestigatorCo-Principal InvestigatorPrincipal InvestigatorPrincipal InvestigatorPrincipal InvestigatorPrincipal InvestigatorPrincipal InvestigatorPrincipal InvestigatorPrincipal InvestigatorCo-Principal InvestigatorDepartment of NeurologyDepartment of NeuroscienceDepartment of PediatricsDepartment of Molecular & Human GeneticsDepartment of NeurosurgeryMolecular & Human GeneticsNeurologyNeuroscienceNeurosurgeryPediatrics-NeurologyBaylor College of MedicineBENJAMINDENEENBENJAMIN DENEEN0.000000000000000.000000000000001530DENEEN, BENJAMINProfessorYADOLLAHHARATIYADOLLAH HARATI0.000000000000000.000000000000002373HARATI, YADOLLAHProfessorJAMESFROST, JRJAMES FROST, JR0.000000000000000.000000000000002335FROST, JR, JAMESDistinguished Emeritus ProfessorHUDAZOGHBIHUDA ZOGHBI29.71010310000000-95.397396100000002830ZOGHBI, HUDADistinguished Service ProfessorJAMESLUPSKIJAMES LUPSKI29.71073630000000-95.396604500000003140LUPSKI, JAMESProfessorALICAGOLDMANALICA GOLDMAN29.70705990000000-95.400460000000003370GOLDMAN, ALICAAssociate ProfessorJOHNSWANNJOHN SWANN32.31117320000000-90.076813400000003379SWANN, JOHNDistinguished Emeritus ProfessorZULFIHANEEFZULFI HANEEF0.000000000000000.000000000000003975HANEEF, ZULFIAssociate ProfessorATULMAHESHWARIATUL MAHESHWARI0.000000000000000.000000000000004225MAHESHWARI, ATULAssociate ProfessorVENEETHACHERIANVENEETHA CHERIAN0.000000000000000.000000000000004734CHERIAN, VENEETHAAssistant Professor8.698590.00386856770research areas4.304720.0106878coauthor of117.86325.722960similar to11212selected publicationsAuthorship 943885130698758Noebels JLBrain : a journal of neurologyBrainstem spreading depolarization: rapid descent into the shadow of SUDEP. Brain. 2019 02 01; 142(2):231-233.Brain2019-02-01T00:00:002019Brainstem spreading depolarization: rapid descent into the shadow of SUDEP.Authorship 1289778Authorship 129190323909851Wilcox KS, Dixon-Salazar T, Sills GJ, Ben-Menachem E, White HS, Porter RJ, Dichter MA, Mosh? SL, Noebels JL, Privitera MD, Rogawski MAEpilepsiaIssues related to development of new antiseizure treatments. Epilepsia. 2013 Aug; 54 Suppl 4:24-34.Epilepsia2013-08-01T00:00:002013Issues related to development of new antiseizure treatments.24065886Maheshwari A, Nahm WK, Noebels JLFrontiers in cellular neuroscienceParadoxical proepileptic response to NMDA receptor blockade linked to cortical interneuron defect in stargazer mice. Front Cell Neurosci. 2013; 7:156.Front Cell Neurosci2013-09-18T00:00:002013Paradoxical proepileptic response to NMDA receptor blockade linked to cortical interneuron defect in stargazer mice.Authorship 947110431087652Mahoney JM, Mills JD, Muhlebner A, Noebels J, Potschka H, Simonato M, Kobow KEpilepsia2017 WONOEP appraisal: Studying epilepsy as a network disease using systems biology approaches. Epilepsia. 2019 06; 60(6):1045-1053.Epilepsia2019-05-14T00:00:0020192017 WONOEP appraisal: Studying epilepsy as a network disease using systems biology approaches.Authorship 11225610Authorship 1081074Authorship 9576591431636454Chen CJ, Sgritta M, Mays J, Zhou H, Lucero R, Park J, Wang IC, Park JH, Kaipparettu BA, Stoica L, Jafar-Nejad P, Rigo F, Chin J, Noebels JL, Costa-Mattioli MNature medicineTherapeutic inhibition of mTORC2 rescues the behavioral and neurophysiological abnormalities associated with Pten-deficiency. Nat Med. 2019 11; 25(11):1684-1690.Nat Med2019-10-21T00:00:002019Therapeutic inhibition of mTORC2 rescues the behavioral and neurophysiological abnormalities associated with Pten-deficiency.true1ProfessorProfessorAuthorship 962108431800012Miao QL, Herlitze S, Mark MD, Noebels JLBrain : a journal of neurologyAdult loss of Cacna1a in mice recapitulates childhood absence epilepsy by distinct thalamic bursting mechanisms. Brain. 2020 01 01; 143(1):161-174.Brain2020-01-01T00:00:002020Adult loss of Cacna1a in mice recapitulates childhood absence epilepsy by distinct thalamic bursting mechanisms.true1Assistant ProfessorAssistant ProfessorAuthorship 975275131904123Noebels JLEpilepsiaPredicting the impact of sodium channel mutations in human brain disease. Epilepsia. 2019 12; 60 Suppl 3:S8-S16.Epilepsia2019-12-01T00:00:002019Predicting the impact of sodium channel mutations in human brain disease.Authorship 9766901531996845Yu K, Lin CJ, Hatcher A, Lozzi B, Kong K, Huang-Hobbs E, Cheng YT, Beechar VB, Zhu W, Zhang Y, Chen F, Mills GB, Mohila CA, Creighton CJ, Noebels JL, Scott KL, Deneen BNaturePIK3CA variants selectively initiate brain hyperactivity during gliomagenesis. Nature. 2020 02; 578(7793):166-171.Nature2020-01-29T00:00:002020PIK3CA variants selectively initiate brain hyperactivity during gliomagenesis.Authorship 977604332033960Siehr MS, Massey CA, Noebels JLDisease models & mechanismsArx expansion mutation perturbs cortical development by augmenting apoptosis without activating innate immunity in a mouse model of X-linked infantile spasms syndrome. Dis Model Mech. 2020 03 30; 13(3).Dis Model Mech2020-03-30T00:00:002020Arx expansion mutation perturbs cortical development by augmenting apoptosis without activating innate immunity in a mouse model of X-linked infantile spasms syndrome.Authorship 1129373RAHULDAMANIRAHUL DAMANI0.000000000000000.000000000000005979DAMANI, RAHULAssociate ProfessorISAMUAIBAISAMU AIBA0.000000000000000.000000000000006801AIBA, ISAMUAssistant ProfessorAuthorship 1133291Authorship 986529632250339Hatcher A, Yu K, Meyer J, Aiba I, Deneen B, Noebels JLThe Journal of clinical investigationPathogenesis of peritumoral hyperexcitability in an immunocompetent CRISPR-based glioblastoma model. J Clin Invest. 2020 05 01; 130(5):2286-2300.J Clin Invest2020-05-01T00:00:002020Pathogenesis of peritumoral hyperexcitability in an immunocompetent CRISPR-based glioblastoma model.Authorship 11585242021-04-30NIHNOEBELS, JEFFREY2020-05-012020 Mechanisms of Epilepsy and Neuronal Synchronization GRC/GRSR13NS116945Principal InvestigatorAuthorship 989702732425157Liu CH, Seo R, Ho TS, Stankewich M, Mohler PJ, Hund TJ, Noebels JL, Rasband MNeLife? spectrin-dependent and domain specific mechanisms for Na+ channel clustering. Elife. 2020 05 19; 9.Elife2020-05-19T00:00:002020? spectrin-dependent and domain specific mechanisms for Na+ channel clustering.2025-03-31NIHJIANG, XIAOLONG ;NOEBELS, JEFFREY2020-06-15Development of aberrant cortical interneuron circuitry in genetic mouse models of absence epilepsyR01NS110767Co-Principal Investigatortrue1ProfessorProfessortrue1Assistant ProfessorAssistant ProfessorAuthorship 1003201233081517Lam AD, Noebels JEpilepsy currentsNight Watch on the Titanic: Detecting Early Signs of Epileptogenesis in Alzheimer Disease. Epilepsy Curr. 2020 Nov-Dec; 20(6):369-374.Epilepsy Curr2020-10-20T00:00:002020Night Watch on the Titanic: Detecting Early Signs of Epileptogenesis in Alzheimer Disease.true1Associate ProfessorAssociate ProfessorAuthorship 1149161Authorship 1154614Authorship 1013648633711494Loring KE, Mattiske T, Lee K, Zysk A, Jackson MR, Noebels JL, Shoubridge CNeurobiology of diseaseEarly 17?-estradiol treatment reduces seizures but not abnormal behaviour in mice with expanded polyalanine tracts in the Aristaless related homeobox gene (ARX). Neurobiol Dis. 2021 06; 153:105329.Neurobiol Dis2021-03-10T00:00:002021Early 17?-estradiol treatment reduces seizures but not abnormal behaviour in mice with expanded polyalanine tracts in the Aristaless related homeobox gene (ARX).true1Associate ProfessorAssociate ProfessorAuthorship 1014578233768249Aiba I, Noebels JLBrain : a journal of neurologyKcnq2/Kv7.2 controls the threshold and bi-hemispheric symmetry of cortical spreading depolarization. Brain. 2021 10 22; 144(9):2863-2878.Brain2021-10-22T00:00:002021Kcnq2/Kv7.2 controls the threshold and bi-hemispheric symmetry of cortical spreading depolarization.Authorship 1015554633787378Buchanan GF, Gluckman BJ, Kalume FK, Lhatoo S, Maganti RK, Noebels JL, Simeone KA, Quigg MS, Pavlova MKEpilepsy currentsProceedings of the Sleep and Epilepsy Workshop: Section 3 Mortality: Sleep, Night, and SUDEP. Epilepsy Curr. 2021 Mar 31; 15357597211004556.Epilepsy Curr2021-03-31T00:00:002021Proceedings of the Sleep and Epilepsy Workshop: Section 3 Mortality: Sleep, Night, and SUDEP.Authorship 1151951Authorship 1027834934396109Massey CA, Thompson SJ, Ostrom RW, Drabek J, Sveinsson OA, Tomson T, Haas EA, Mena OJ, Goldman AM, Noebels JLBrain communicationsX-linked serotonin 2C receptor is associated with a non-canonical pathway for sudden unexpected death in epilepsy. Brain Commun. 2021; 3(3):fcab149.Brain Commun2021-07-09T00:00:002021X-linked serotonin 2C receptor is associated with a non-canonical pathway for sudden unexpected death in epilepsy.Authorship 11777710Authorship 1177808Authorship 1201241Authorship 1192896Authorship 159453Authorship 1203094Authorship 10605054Authorship 10627589Authorship 10569472Authorship 1058532336417872Aloi MS, Thompson SJ, Quartapella N, Noebels JLCell reportsLoss of functional System x-c uncouples aberrant postnatal neurogenesis from epileptogenesis in the hippocampus of Kcna1-KO mice. Cell Rep. 2022 11 22; 41(8):111696.Cell Rep2022-11-22T00:00:002022Loss of functional System x-c uncouples aberrant postnatal neurogenesis from epileptogenesis in the hippocampus of Kcna1-KO mice.36192157Ning Y, Noebels JL, Aiba IeNeuroEmx1-Cre Is Expressed in Peripheral Autonomic Ganglia That Regulate Central Cardiorespiratory Functions. eNeuro. 2022 Sep-Oct; 9(5).eNeuro2022-10-17T00:00:002022Emx1-Cre Is Expressed in Peripheral Autonomic Ganglia That Regulate Central Cardiorespiratory Functions.36614191Goethe EA, Deneen B, Noebels J, Rao GInternational journal of molecular sciencesThe Role of Hyperexcitability in Gliomagenesis. Int J Mol Sci. 2023 Jan 01; 24(1).Int J Mol Sci2023-01-01T00:00:002023The Role of Hyperexcitability in Gliomagenesis.35972048Liang JH, Alevy J, Akhanov V, Seo R, Massey CA, Jiang D, Zhou J, Sillitoe RV, Noebels JL, Samuel MADisease models & mechanismsKctd7 deficiency induces myoclonic seizures associated with Purkinje cell death and microvascular defects. Dis Model Mech. 2022 09 01; 15(9).Dis Model Mech2022-09-01T00:00:002022Kctd7 deficiency induces myoclonic seizures associated with Purkinje cell death and microvascular defects.Authorship 10640841636787748Curry RN, Aiba I, Meyer J, Lozzi B, Ko Y, McDonald MF, Rosenbaum A, Cervantes A, Huang-Hobbs E, Cocito C, Greenfield JP, Jalali A, Gavvala J, Mohila C, Serin Harmanci A, Noebels J, Rao G, Deneen BNeuronGlioma epileptiform activity and progression are driven by IGSF3-mediated potassium dysregulation. Neuron. 2023 03 01; 111(5):682-695.e9.Neuron2023-02-13T00:00:002023Glioma epileptiform activity and progression are driven by IGSF3-mediated potassium dysregulation.Authorship 1064514936828035Hussain T, Sanchez K, Crayton J, Saha D, Jeter C, Lu Y, Abba M, Seo R, Noebels JL, Fonken L, Aldaz CMProgress in neurobiologyWWOX P47T partial loss-of-function mutation induces epilepsy, progressive neuroinflammation, and cerebellar degeneration in mice phenocopying human SCAR12. Prog Neurobiol. 2023 04; 223:102425.Prog Neurobiol2023-02-23T00:00:002023WWOX P47T partial loss-of-function mutation induces epilepsy, progressive neuroinflammation, and cerebellar degeneration in mice phenocopying human SCAR12.Authorship 17904Authorship 10674062136993539Huang-Hobbs E, Cheng YT, Ko Y, Luna-Figueroa E, Lozzi B, Taylor KR, McDonald M, He P, Chen HC, Yang Y, Maleki E, Lee ZF, Murali S, Williamson M, Choi D, Curry R, Bayley J, Woo J, Jalali A, Monje M, Noebels JL, Harmanci AS, Rao G, Deneen BbioRxiv : the preprint server for biologyRemote neuronal activity drives glioma infiltration via Sema4f. bioRxiv. 2023 Mar 16.bioRxiv2023-03-16T00:00:002023Remote neuronal activity drives glioma infiltration via Sema4f.Authorship 12432Authorship 10731092137380778Huang-Hobbs E, Cheng YT, Ko Y, Luna-Figueroa E, Lozzi B, Taylor KR, McDonald M, He P, Chen HC, Yang Y, Maleki E, Lee ZF, Murali S, Williamson MR, Choi D, Curry R, Bayley J, Woo J, Jalali A, Monje M, Noebels JL, Harmanci AS, Rao G, Deneen BNatureRemote neuronal activity drives glioma progression through SEMA4F. Nature. 2023 Jul; 619(7971):844-850.Nature2023-06-28T00:00:002023Remote neuronal activity drives glioma progression through SEMA4F.true1Associate ProfessorAssociate ProfessorAuthorship 1079178337551713Aiba I, Ning Y, Noebels JLJCI insightA hyperthermic seizure unleashes a surge of spreading depolarizations in Scn1a-deficient mice. JCI Insight. 2023 08 08; 8(15).JCI Insight2023-08-08T00:00:002023A hyperthermic seizure unleashes a surge of spreading depolarizations in Scn1a-deficient mice.true1Distinguished Emeritus ProfessorDistinguished Emeritus Professortrue1Distinguished Emeritus ProfessorDistinguished Emeritus ProfessorAuthorship 201395true1Assistant ProfessorAssistant ProfessorAuthorship 10846131237963879Okoh J, Mays J, Bacq A, Oses-Prieto JA, Tyanova S, Chen CJ, Imanbeyev K, Doladilhe M, Zhou H, Jafar-Nejad P, Burlingame A, Noebels J, Baulac S, Costa-Mattioli MNature communicationsTargeted suppression of mTORC2 reduces seizures across models of epilepsy. Nat Commun. 2023 11 14; 14(1):7364.Nat Commun2023-11-14T00:00:002023Targeted suppression of mTORC2 reduces seizures across models of epilepsy.Authorship 1085256538123552Villacres JE, Riveira N, Kim S, Colgin LL, Noebels JL, Lopez AYTranslational psychiatryAbnormal patterns of sleep and waking behaviors are accompanied by neocortical oscillation disturbances in an Ank3 mouse model of epilepsy-bipolar disorder comorbidity. Transl Psychiatry. 2023 Dec 20; 13(1):403.Transl Psychiatry2023-12-20T00:00:002023Abnormal patterns of sleep and waking behaviors are accompanied by neocortical oscillation disturbances in an Ank3 mouse model of epilepsy-bipolar disorder comorbidity.Authorship 228793Authorship 10878102138260608Abreo TJ, Thompson EC, Madabushi A, Soh H, Varghese N, Vanoye CG, Springer K, Park KL, Johnson J, Sims S, Ji Z, Chavez AG, Jankovic MJ, Habte B, Zuberi A, Lutz C, Wang Z, Krishnan V, Dudler L, Einsele-Scholz S, Noebels JL, George AL, Maheshwari A, Tzingounis AV, Cooper ECbioRxiv : the preprint server for biologyPlural molecular and cellular mechanisms of pore domain KCNQ2 encephalopathy. bioRxiv. 2024 Feb 08.bioRxiv2024-02-08T00:00:002024Plural molecular and cellular mechanisms of pore domain KCNQ2 encephalopathy.Authorship 172522Authorship 192182Authorship 10909711538496434Curry RN, Ma Q, McDonald MF, Ko Y, Srivastava S, Chin PS, He P, Lozzi B, Aiba I, Meyer J, Jing J, Wang S, Harmanci AO, Athukuri P, Noebels J, Arenkiel B, Jiang X, Deneen B, Rao G, Harmanci ASbioRxiv : the preprint server for biologySpiking GABAergic OPC tumor cells prolong survival in IDH1 mutant glioma. bioRxiv. 2024 Mar 06.bioRxiv2024-03-06T00:00:002024Spiking GABAergic OPC tumor cells prolong survival in IDH1 mutant glioma.true1ProfessorProfessorAuthorship 237409Authorship 242022Authorship 210577Authorship 259921Authorship 29203Authorship 353501Authorship 377732Authorship 393701Authorship 435285Authorship 14175010Authorship 1419513Authorship 1431811224372310Klassen TL, Bomben VC, Patel A, Drabek J, Chen TT, Gu W, Zhang F, Chapman K, Lupski JR, Noebels JL, Goldman AMEpilepsiaHigh-resolution molecular genomic autopsy reveals complex sudden unexpected death in epilepsy risk profile. Epilepsia. 2014 Feb; 55(2):e6-12.Epilepsia2013-12-24T00:00:002013High-resolution molecular genomic autopsy reveals complex sudden unexpected death in epilepsy risk profile.24452264Olivetti PR, Maheshwari A, Noebels JLScience translational medicineNeonatal estradiol stimulation prevents epilepsy in Arx model of X-linked infantile spasms syndrome. Sci Transl Med. 2014 Jan 22; 6(220):220ra12.Sci Transl Med2014-01-22T00:00:002014Neonatal estradiol stimulation prevents epilepsy in Arx model of X-linked infantile spasms syndrome.24623762Born HA, Kim JY, Savjani RR, Das P, Dabaghian YA, Guo Q, Yoo JW, Schuler DR, Cirrito JR, Zheng H, Golde TE, Noebels JL, Jankowsky JLThe Journal of neuroscience : the official journal of the Society for NeuroscienceGenetic suppression of transgenic APP rescues Hypersynchronous network activity in a mouse model of Alzeimer's disease. J Neurosci. 2014 Mar 12; 34(11):3826-40.J Neurosci2014-03-12T00:00:002014Genetic suppression of transgenic APP rescues Hypersynchronous network activity in a mouse model of Alzeimer's disease.Authorship 345628Authorship 486722Authorship 52057Authorship 354474Authorship 366051Authorship 558831Authorship 412207Authorship 400271Authorship 416971Authorship 404081Authorship 410368Authorship 1454836Authorship 1466651324767949Bomben V, Holth J, Reed J, Cramer P, Landreth G, Noebels JNeurobiology of agingBexarotene reduces network excitability in models of Alzheimer's disease and epilepsy. Neurobiol Aging. 2014 Sep; 35(9):2091-5.Neurobiol Aging2014-04-02T00:00:002014Bexarotene reduces network excitability in models of Alzheimer's disease and epilepsy.24945774Ozkan ED, Creson TK, Kram?r EA, Rojas C, Seese RR, Babyan AH, Shi Y, Lucero R, Xu X, Noebels JL, Miller CA, Lynch G, Rumbaugh GNeuronReduced cognition in Syngap1 mutants is caused by isolated damage within developing forebrain excitatory neurons. Neuron. 2014 Jun 18; 82(6):1317-33.Neuron2014-06-18T00:00:002014Reduced cognition in Syngap1 mutants is caused by isolated damage within developing forebrain excitatory neurons.Authorship 451342Authorship 461615Authorship 669883Authorship 495102Authorship 501172Authorship 705614Authorship 148366225012387Guerrini R, Noebels JAdvances in experimental medicine and biologyHow can advances in epilepsy genetics lead to better treatments and cures? Adv Exp Med Biol. 2014; 813:309-17.Adv Exp Med Biol2014-01-01T00:00:002014How can advances in epilepsy genetics lead to better treatments and cures?Authorship 524893Authorship 530064Authorship 75591Authorship 544264Authorship 542371Authorship 548231Authorship 797934Authorship 8114612Authorship 57611Authorship 837594Authorship 602831Authorship 848604Authorship 15162011Authorship 151626225189211Qi Y, Wang J, Bomben VC, Li DP, Chen SR, Sun H, Xi Y, Reed JG, Cheng J, Pan HL, Noebels JL, Yeh ETNeuronHyper-SUMOylation of the Kv7 potassium channel diminishes the M-current leading to seizures and sudden death. Neuron. 2014 Sep 03; 83(5):1159-71.Neuron2014-09-03T00:00:002014Hyper-SUMOylation of the Kv7 potassium channel diminishes the M-current leading to seizures and sudden death.25194492Maheshwari A, Noebels JLProgress in brain researchMonogenic models of absence epilepsy: windows into the complex balance between inhibition and excitation in thalamocortical microcircuits. Prog Brain Res. 2014; 213:223-52.Prog Brain Res2014-01-01T00:00:002014Monogenic models of absence epilepsy: windows into the complex balance between inhibition and excitation in thalamocortical microcircuits.Authorship 618524Authorship 62322Authorship 857242Authorship 628142Authorship 6218013Authorship 645622Authorship 913782Authorship 671462Authorship 673454Authorship 944075Authorship 982493Authorship 699202Authorship 734719Authorship 749183Authorship 733661Authorship 768663Authorship 761676Authorship 780263Authorship 767508