BETTYSLAGLEBETTY SLAGLE0.000000000000000.000000000000002513SLAGLE, BETTYHepatitis B virus
Liver cancer
Viral hepatitisAssociate Professorprns:coAuthorOfcoauthor ofprns:emailEncryptedemail addressprns:endDateend dateFaculty Rankprns:fullNamefull nameprns:grantAwardedBygrant awarded byprns:hasAuthorListauthor listprns:hasFacultyRankhas faculty rankprns:hasNetworkhas networkprns:hasPublicationVenuepublished inprns:informationResourceReferenceinformation resource referenceprns:isPrimaryPositionis primary positionprns:latitudelatitudeprns:longitudelongitudeprns:mainImagephotoprns:maxWeightmaximum weightprns:medlineTAjournal title abbreviationprns:meshDescriptorUIMeSH DescriptorUIprns:meshSemanticGroupNameMeSH semantic group nameprns:minWeightminimum weightprns:numberOfAuthorsnumber of authorsprns:numberOfConnectionsnumber of connectionsprns:numberOfPublicationsnumber of publicationsprns:personIdPerson IDprns:personInPrimaryPositionperson in primary positionprns:physicalNeighborOfphysical neighborprns:positionInDepartmentposition in departmentprns:positionInDivisionposition in divisionprns:predicateNodepredicate nodeprns:principalInvestigatorNameprincipal investigator nameprns:publicationDatepublication dateprns:similarTosimilar toprns:sortOrdersort orderprns:startDatestart dateprns:uniquenessWeightuniqueness weightprns:yearyearAcademic ArticleArticleDocumentbibo:pmidPubMed IdentifierAddressvivo:address1address line 1vivo:addressCitycityvivo:addressPostalCodepostal codeAgreementvivo:authorInAuthorshipselected publicationsvivo:authorRankauthor rank in publicationAuthorshipDepartmentDivisionvivo:freetextKeywordkeywordsGrantvivo:hasResearchArearesearch areasvivo:hasResearcherRoleresearch activitiesvivo:hrJobTitleHR job titleInformation Resourcevivo:linkedAuthorlinked authorvivo:linkedInformationResourcelinked information resourcevivo:mailingAddressmailing addressvivo:personInPositionpositionsPositionvivo:positionInOrganizationposition in organizationvivo:preferredTitlepreferred titleResearcher Rolevivo:researcherRoleOfresearcher role ofRolevivo:roleContributesTocontributes tovivo:sponsorAwardIdsponsor award idrdf:predicatepredicaterdf:typetyperdfs:labellabelConceptAgentfoaf:firstNamefirst namefoaf:lastNamelast nameOrganizationPerson25362482Totoki Y, Tatsuno K, Covington KR, Ueda H, Creighton CJ, Kato M, Tsuji S, Donehower LA, Slagle BL, Nakamura H, Yamamoto S, Shinbrot E, Hama N, Lehmkuhl M, Hosoda F, Arai Y, Walker K, Dahdouli M, Gotoh K, Nagae G, Gingras MC, Muzny DM, Ojima H, Shimada K, Midorikawa Y, Goss JA, Cotton R, Hayashi A, Shibahara J, Ishikawa S, Guiteau J, Tanaka M, Urushidate T, Ohashi S, Okada N, Doddapaneni H, Wang M, Zhu Y, Dinh H, Okusaka T, Kokudo N, Kosuge T, Takayama T, Fukayama M, Gibbs RA, Wheeler DA, Aburatani H, Shibata TNature geneticsTrans-ancestry mutational landscape of hepatocellular carcinoma genomes. Nat Genet. 2014 Dec; 46(12):1267-73.Nat Genet2014-11-02T00:00:002014Trans-ancestry mutational landscape of hepatocellular carcinoma genomes.25421893Minor MM, Slagle BLVirusesHepatitis B virus HBx protein interactions with the ubiquitin proteasome system. Viruses. 2014 Nov 24; 6(11):4683-702.Viruses2014-11-24T00:00:002014Hepatitis B virus HBx protein interactions with the ubiquitin proteasome system.Authorship 134565Authorship 160763125099228Slagle BL, Andrisani OM, Bouchard MJ, Lee CG, Ou JH, Siddiqui AHepatology (Baltimore, Md.)Technical standards for hepatitis B virus X protein (HBx) research. Hepatology. 2015 Apr; 61(4):1416-24.Hepatology2015-03-09T00:00:002015Technical standards for hepatitis B virus X protein (HBx) research.General Internal MedicineSystems BiologyMD AndersonSHIAW-YIHLINSHIAW-YIH LIN8696LIN, SHIAW-YIHProfessorJESSICA PHWANGJESSICA P HWANG8934HWANG, JESSICA PAssociate ProfessorAuthorship 299211626433160Chung W, Kim M, de la Monte S, Longato L, Carlson R, Slagle BL, Dong X, Wands JRCancer lettersActivation of signal transduction pathways during hepatic oncogenesis. Cancer Lett. 2016 Jan 01; 370(1):1-9.Cancer Lett2015-10-01T00:00:002015Activation of signal transduction pathways during hepatic oncogenesis.Molecular Virology & MicrobiologyHouston, 7703074Professor21Chair5Adjunct Instructor14Associate Professor3Adjunct Associate Professor78Professor Emeritus47Distinguished Service Professor16427673Keasler VV, Lerat H, Madden CR, Finegold MJ, McGarvey MJ, Mohammed EM, Forbes SJ, Lemon SM, Hadsell DL, Grona SJ, Hollinger FB, Slagle BLVirologyIncreased liver pathology in hepatitis C virus transgenic mice expressing the hepatitis B virus X protein. Virology. 2006 Apr 10; 347(2):466-75.Virology2006-01-20T00:00:002006Increased liver pathology in hepatitis C virus transgenic mice expressing the hepatitis B virus X protein.Authorship 320518126747833Slagle BL, Bouchard MJCold Spring Harbor perspectives in medicineHepatitis B Virus X and Regulation of Viral Gene Expression. Cold Spring Harb Perspect Med. 2016 Jan 08; 6(3):a021402.Cold Spring Harb Perspect Med2016-01-08T00:00:002016Hepatitis B Virus X and Regulation of Viral Gene Expression.19464721Keasler VV, Hodgson AJ, Madden CR, Slagle BLVirologyHepatitis B virus HBx protein localized to the nucleus restores HBx-deficient virus replication in HepG2 cells and in vivo in hydrodynamically-injected mice. Virology. 2009 Jul 20; 390(1):122-9.Virology2009-05-23T00:00:002009Hepatitis B virus HBx protein localized to the nucleus restores HBx-deficient virus replication in HepG2 cells and in vivo in hydrodynamically-injected mice.19475691Longato L, de la Monte S, Kuzushita N, Horimoto M, Rogers AB, Slagle BL, Wands JRHepatology (Baltimore, Md.)Overexpression of insulin receptor substrate-1 and hepatitis Bx genes causes premalignant alterations in the liver. Hepatology. 2009 Jun; 49(6):1935-43.Hepatology2009-06-01T00:00:002009Overexpression of insulin receptor substrate-1 and hepatitis Bx genes causes premalignant alterations in the liver.18688024Connolly E, Melegari M, Landgraf P, Tchaikovskaya T, Tennant BC, Slagle BL, Rogler LE, Zavolan M, Tuschl T, Rogler CEThe American journal of pathologyElevated expression of the miR-17-92 polycistron and miR-21 in hepadnavirus-associated hepatocellular carcinoma contributes to the malignant phenotype. Am J Pathol. 2008 Sep; 173(3):856-64.Am J Pathol2008-08-07T00:00:002008Elevated expression of the miR-17-92 polycistron and miR-21 in hepadnavirus-associated hepatocellular carcinoma contributes to the malignant phenotype.19074903Hodgson AJ, Keasler VV, Slagle BLCancer researchPremature cell cycle entry induced by hepatitis B virus regulatory HBx protein during compensatory liver regeneration. Cancer Res. 2008 Dec 15; 68(24):10341-8.Cancer Res2008-12-15T00:00:002008Premature cell cycle entry induced by hepatitis B virus regulatory HBx protein during compensatory liver regeneration.Authorship 654673328102638Niu Y, Xu M, Slagle BL, Huang H, Li S, Guo GL, Shi G, Qin W, Xie WHepatology (Baltimore, Md.)Farnesoid X receptor ablation sensitizes mice to hepatitis b virus X protein-induced hepatocarcinogenesis. Hepatology. 2017 03; 65(3):893-906.Hepatology2017-01-19T00:00:002017Farnesoid X receptor ablation sensitizes mice to hepatitis b virus X protein-induced hepatocarcinogenesis.21068253Kumar M, Jung SY, Hodgson AJ, Madden CR, Qin J, Slagle BLJournal of virologyHepatitis B virus regulatory HBx protein binds to adaptor protein IPS-1 and inhibits the activation of beta interferon. J Virol. 2011 Jan; 85(2):987-95.J Virol2010-11-10T00:00:002010Hepatitis B virus regulatory HBx protein binds to adaptor protein IPS-1 and inhibits the activation of beta interferon.22342275Hodgson AJ, Hyser JM, Keasler VV, Cang Y, Slagle BLVirologyHepatitis B virus regulatory HBx protein binding to DDB1 is required but is not sufficient for maximal HBV replication. Virology. 2012 Apr 25; 426(1):73-82.Virology2012-02-17T00:00:002012Hepatitis B virus regulatory HBx protein binding to DDB1 is required but is not sufficient for maximal HBV replication.22387566Luo N, Cai Y, Zhang J, Tang W, Slagle BL, Wu X, He SVirus researchThe C-terminal region of the hepatitis B virus X protein is required for its stimulation of HBV replication in primary mouse hepatocytes. Virus Res. 2012 May; 165(2):170-8.Virus Res2012-02-23T00:00:002012The C-terminal region of the hepatitis B virus X protein is required for its stimulation of HBV replication in primary mouse hepatocytes.Authorship 102114617182675Keasler VV, Hodgson AJ, Madden CR, Slagle BLJournal of virologyEnhancement of hepatitis B virus replication by the regulatory X protein in vitro and in vivo. J Virol. 2007 Mar; 81(6):2656-62.J Virol2006-12-20T00:00:002006Enhancement of hepatitis B virus replication by the regulatory X protein in vitro and in vivo.Authorship 8810071Authorship 881053529491161Freitas N, Lukash T, Gunewardena S, Chappell B, Slagle BL, Gudima SOJournal of virologyRelative Abundance of Integrant-Derived Viral RNAs in Infected Tissues Harvested from Chronic Hepatitis B Virus Carriers. J Virol. 2018 05 15; 92(10).J Virol2018-04-27T00:00:002018Relative Abundance of Integrant-Derived Viral RNAs in Infected Tissues Harvested from Chronic Hepatitis B Virus Carriers.29454995Slagle BL, Bouchard MJCurrent opinion in virologyRole of HBx in hepatitis B virus persistence and its therapeutic implications. Curr Opin Virol. 2018 06; 30:32-38.Curr Opin Virol2018-02-20T00:00:002018Role of HBx in hepatitis B virus persistence and its therapeutic implications.true1ProfessorProfessortrue1Associate ProfessorAssociate Professortrue1ProfessorProfessorAuthorship 1075586D054334Chemicals & Drugs32640.968192Viral Regulatory and Accessory ProteinsD006515Living Beings1032140.840735Hepatitis B virusD015534Chemicals & Drugs52315540.609517Trans-ActivatorsD014779Physiology2517120.747018Virus ReplicationD054884Phenomena1703140.802391Host-Pathogen Interactions2001-03-31NIHSLAGLE, BETTY L1991-03-15HEPATITIS B VIRUS AND HEPATOCELLULAR CARCINOMAR01CA0545572002-06-30NIHSLAGLE, BETTY L2001-07-01International Conference on Hepatitis B VirusesR13AI0500452016-06-30NIHSLAGLE, BETTY L2013-07-01Hepatitis B virus replication and DDB1R21CA1779512009-06-30NIHSLAGLE, BETTY L2003-07-01Hepatitis HBx-Mediated PathogenesisR01CA0953882011-06-30NIHSLAGLE, BETTY L2002-07-01Hepatitis HBx-Mediated PathogenesisR56CA095388Principal InvestigatorPrincipal InvestigatorPrincipal InvestigatorPrincipal InvestigatorPrincipal InvestigatorDepartment of MedicineDepartment of Molecular & Cellular BiologyDepartment of Molecular Virology & MicrobiologyMedicine-Gastroenterology & HepatolMolecular & Cellular BiologyMolecular Virology & MicrobiologyBaylor College of MedicineSARAHBLUTTSARAH BLUTT0.000000000000000.000000000000002152BLUTT, SARAHAssociate ProfessorMARYESTESMARY ESTES0.000000000000000.000000000000002318ESTES, MARYDistinguished Service ProfessorKARL-DIMITERBISSIGKARL-DIMITER BISSIG0.000000000000000.000000000000001893BISSIG, KARL-DIMITERAdjunct Associate ProfessorF. BLAINEHOLLINGERF. BLAINE HOLLINGER0.000000000000000.000000000000002388HOLLINGER, F. BLAINEProfessor EmeritusLAWRENCEDONEHOWERLAWRENCE DONEHOWER0.000000000000000.000000000000003118DONEHOWER, LAWRENCEProfessorMARGARETCONNERMARGARET CONNER0.000000000000000.000000000000003085CONNER, MARGARETAssociate ProfessorFASIHAKANWALFASIHA KANWAL29.70503200000000-95.407546000000004180KANWAL, FASIHAProfessorHASHEMEL-SERAGHASHEM EL-SERAG29.70560750000000-95.3846773000000068EL-SERAG, HASHEMProfessorJOSEPHHYSERPKNhszORdNrVRIzgrn7GPw==JOSEPH HYSER0.000000000000000.0000000000000092HYSER, JOSEPHAssociate ProfessorBERTO'MALLEYBERT O'MALLEY0.000000000000000.000000000000002464O'MALLEY, BERTDistinguished Service Professor3.757270.00611018117research areas0.3908210.032585414coauthor of25.0274.1756960similar to1120selected publicationsROBERTRAMIGROBERT RAMIG0.000000000000000.000000000000002848RAMIG, ROBERTProfessor EmeritusAuthorship 1114873true1ProfessorProfessortrue1Distinguished Service ProfessorDistinguished Service Professortrue1Distinguished Service ProfessorDistinguished Service ProfessorADRIENNEMCNEESADRIENNE MCNEES0.000000000000000.000000000000005767MCNEES, ADRIENNEAdjunct InstructorAuthorship 986245832235678Minor MM, Hollinger FB, McNees AL, Jung SY, Jain A, Hyser JM, Bissig KD, Slagle BLCellsHepatitis B Virus HBx Protein Mediates the Degradation of Host Restriction Factors through the Cullin 4 DDB1 E3 Ubiquitin Ligase Complex. Cells. 2020 03 30; 9(4).Cells2020-03-30T00:00:002020Hepatitis B Virus HBx Protein Mediates the Degradation of Host Restriction Factors through the Cullin 4 DDB1 E3 Ubiquitin Ligase Complex.Authorship 993876632642299Liang Y, Yu L, Zhang D, Zhao X, Gao H, Slagle BL, Goss JA, Wang X, Li K, Lin SYAmerican journal of cancer researchBRIT1 dysfunction confers synergistic inhibition of hepatocellular carcinoma by targeting poly (ADP-ribose) polymerases and PI3K. Am J Cancer Res. 2020; 10(6):1900-1918.Am J Cancer Res2020-06-01T00:00:002020BRIT1 dysfunction confers synergistic inhibition of hepatocellular carcinoma by targeting poly (ADP-ribose) polymerases and PI3K.true1Professor EmeritusProfessor EmeritusAuthorship 1013987933733079Kruse RL, Barzi M, Legras X, Pankowicz FP, Furey N, Liao L, Xu J, Bissig-Choisat B, Slagle BL, Bissig KDJHEP reports : innovation in hepatologyA hepatitis B virus transgenic mouse model with a conditional, recombinant, episomal genome. JHEP Rep. 2021 Apr; 3(2):100252.JHEP Rep2021-02-06T00:00:002021A hepatitis B virus transgenic mouse model with a conditional, recombinant, episomal genome.2024-06-30NIHCRAWFORD, SUE ELLEN ;SLAGLE, BETTY L2021-07-15Small molecule inhibitors of HBx that decrease hepatitis B virus replicationR21AI163439Principal Investigatortrue1Associate ProfessorAssociate Professortrue1Associate ProfessorAssociate Professortrue1Adjunct Associate ProfessorAdjunct Associate Professortrue1Adjunct InstructorAdjunct Instructortrue1Associate ProfessorAssociate Professortrue1Professor EmeritusProfessor Emeritustrue1ProfessorProfessortrue1Associate ProfessorAssociate ProfessorAuthorship 240826Authorship 309612Authorship 966804Authorship 992665Authorship 761854Authorship 1548472Authorship 1556779