BRADLEYMCCONNELLBRADLEY K. MCCONNELL29.72602660000000-95.348164100000004627MCCONNELL, BRADLEYK.Associate Professorprns:coAuthorOfcoauthor ofprns:endDateend dateFaculty Rankprns:fullNamefull nameprns:grantAwardedBygrant awarded byprns:hasAuthorListauthor listprns:hasFacultyRankhas faculty rankprns:hasNetworkhas networkprns:hasPublicationVenuepublished inprns:informationResourceReferenceinformation resource referenceprns:isPrimaryPositionis primary positionprns:latitudelatitudeprns:longitudelongitudeprns:mainImagephotoprns:maxWeightmaximum weightprns:medlineTAjournal title abbreviationprns:meshDescriptorUIMeSH DescriptorUIprns:meshSemanticGroupNameMeSH semantic group nameprns:minWeightminimum weightprns:numberOfAuthorsnumber of authorsprns:numberOfConnectionsnumber of connectionsprns:numberOfPublicationsnumber of publicationsprns:personIdPerson IDprns:personInPrimaryPositionperson in primary positionprns:physicalNeighborOfphysical neighborprns:positionInDepartmentposition in departmentprns:positionInDivisionposition in divisionprns:predicateNodepredicate nodeprns:principalInvestigatorNameprincipal investigator nameprns:publicationDatepublication dateprns:similarTosimilar toprns:sortOrdersort orderprns:startDatestart dateprns:uniquenessWeightuniqueness weightprns:yearyearAcademic ArticleArticleDocumentbibo:pmidPubMed IdentifierAddressvivo:address1address line 1vivo:address2address line 2vivo:addressCitycityvivo:addressPostalCodepostal codevivo:addressStatestate or provinceAgreementvivo:authorInAuthorshipselected publicationsvivo:authorRankauthor rank in publicationAuthorshipDepartmentDivisionGrantvivo:hasResearchArearesearch areasvivo:hasResearcherRoleresearch activitiesvivo:hrJobTitleHR job titleInformation Resourcevivo:linkedAuthorlinked authorvivo:linkedInformationResourcelinked information resourcevivo:mailingAddressmailing addressvivo:middleNamemiddle name or initialvivo:personInPositionpositionsPositionvivo:positionInOrganizationposition in organizationvivo:preferredTitlepreferred titleResearcher Rolevivo:researcherRoleOfresearcher role ofRolevivo:roleContributesTocontributes tovivo:sponsorAwardIdsponsor award idrdf:predicatepredicaterdf:typetyperdfs:labellabelConceptAgentfoaf:firstNamefirst namefoaf:lastNamelast nameOrganizationPersonAuthorship 814213Authorship 923638Authorship 971973Authorship 1137252Authorship 152241Authorship 154941Authorship 162441625547489Rababa'h A, Singh S, Suryavanshi SV, Altarabsheh SE, Deo SV, McConnell BKInternational journal of molecular sciencesCompartmentalization role of A-kinase anchoring proteins (AKAPs) in mediating protein kinase A (PKA) signaling and cardiomyocyte hypertrophy. Int J Mol Sci. 2014 Dec 24; 16(1):218-29.Int J Mol Sci2014-12-24T00:00:002014Compartmentalization role of A-kinase anchoring proteins (AKAPs) in mediating protein kinase A (PKA) signaling and cardiomyocyte hypertrophy.Authorship 273311Authorship 609135Authorship 630591Authorship 665704Authorship 996318925574Zhang BX, Ma X, McConnell BK, Damron DS, Bond MCirculation researchActivation of purinergic receptors triggers oscillatory contractions in adult rat ventricular myocytes. Circ Res. 1996 Jul; 79(1):94-102.Circ Res1996-07-01T00:00:001996Activation of purinergic receptors triggers oscillatory contractions in adult rat ventricular myocytes.9321836McConnell BK, Moravec CS, Morano I, Bond MThe American journal of physiologyTroponin I phosphorylation in spontaneously hypertensive rat heart: effect of beta-adrenergic stimulation. Am J Physiol. 1997 Sep; 273(3 Pt 2):H1440-51.Am J Physiol1997-09-01T00:00:001997Troponin I phosphorylation in spontaneously hypertensive rat heart: effect of beta-adrenergic stimulation.9486239McConnell BK, Moravec CS, Bond MThe American journal of physiologyTroponin I phosphorylation and myofilament calcium sensitivity during decompensated cardiac hypertrophy. Am J Physiol. 1998 02; 274(2):H385-96.Am J Physiol1998-02-01T00:00:001998Troponin I phosphorylation and myofilament calcium sensitivity during decompensated cardiac hypertrophy.9884344Fatkin D, Christe ME, Aristizabal O, McConnell BK, Srinivasan S, Schoen FJ, Seidman CE, Turnbull DH, Seidman JGThe Journal of clinical investigationNeonatal cardiomyopathy in mice homozygous for the Arg403Gln mutation in the alpha cardiac myosin heavy chain gene. J Clin Invest. 1999 Jan; 103(1):147-53.J Clin Invest1999-01-01T00:00:001999Neonatal cardiomyopathy in mice homozygous for the Arg403Gln mutation in the alpha cardiac myosin heavy chain gene.8300648Xing M, Wilkins PL, McConnell BK, Mattera RThe Journal of biological chemistryRegulation of phospholipase A2 activity in undifferentiated and neutrophil-like HL60 cells. Linkage between impaired responses to agonists and absence of protein kinase C-dependent phosphorylation of cytosolic phospholipase A2. J Biol Chem. 1994 Jan 28; 269(4):3117-24.J Biol Chem1994-01-28T00:00:001994Regulation of phospholipase A2 activity in undifferentiated and neutrophil-like HL60 cells. Linkage between impaired responses to agonists and absence of protein kinase C-dependent phosphorylation of cytosolic phospholipase A2.Authorship 3000551Authorship 304701826153423Jiang J, Burgon PG, Wakimoto H, Onoue K, Gorham JM, O'Meara CC, Fomovsky G, McConnell BK, Lee RT, Seidman JG, Seidman CEProceedings of the National Academy of Sciences of the United States of AmericaCardiac myosin binding protein C regulates postnatal myocyte cytokinesis. Proc Natl Acad Sci U S A. 2015 Jul 21; 112(29):9046-51.Proc Natl Acad Sci U S A2015-07-07T00:00:002015Cardiac myosin binding protein C regulates postnatal myocyte cytokinesis.26379556McConnell BK, Singh S, Fan Q, Hernandez A, Portillo JP, Reiser PJ, Tikunova SBFrontiers in physiologyKnock-in mice harboring a Ca(2+) desensitizing mutation in cardiac troponin C develop early onset dilated cardiomyopathy. Front Physiol. 2015; 6:242.Front Physiol2015-08-27T00:00:002015Knock-in mice harboring a Ca(2+) desensitizing mutation in cardiac troponin C develop early onset dilated cardiomyopathy.11104788Fatkin D, McConnell BK, Mudd JO, Semsarian C, Moskowitz IG, Schoen FJ, Giewat M, Seidman CE, Seidman JGThe Journal of clinical investigationAn abnormal Ca(2+) response in mutant sarcomere protein-mediated familial hypertrophic cardiomyopathy. J Clin Invest. 2000 Dec; 106(11):1351-9.J Clin Invest2000-12-01T00:00:002000An abnormal Ca(2+) response in mutant sarcomere protein-mediated familial hypertrophic cardiomyopathy.74Professor10Assistant Professor14Associate Professor3Adjunct Associate Professor6Adjunct Professor11230104McConnell BK, Fatkin D, Semsarian C, Jones KA, Georgakopoulos D, Maguire CT, Healey MJ, Mudd JO, Moskowitz IP, Conner DA, Giewat M, Wakimoto H, Berul CI, Schoen FJ, Kass DA, Seidman CE, Seidman JGCirculation researchComparison of two murine models of familial hypertrophic cardiomyopathy. Circ Res. 2001 Mar 02; 88(4):383-9.Circ Res2001-03-02T00:00:002001Comparison of two murine models of familial hypertrophic cardiomyopathy.11524317Sprung J, Ogletree-Hughes ML, McConnell BK, Zakhary DR, Smolsky SM, Moravec CSAnesthesia and analgesiaThe effects of propofol on the contractility of failing and nonfailing human heart muscles. Anesth Analg. 2001 Sep; 93(3):550-9.Anesth Analg2001-09-01T00:00:002001The effects of propofol on the contractility of failing and nonfailing human heart muscles.11723028Berul CI, McConnell BK, Wakimoto H, Moskowitz IP, Maguire CT, Semsarian C, Vargas MM, Gehrmann J, Seidman CE, Seidman JGCirculationVentricular arrhythmia vulnerability in cardiomyopathic mice with homozygous mutant Myosin-binding protein C gene. Circulation. 2001 Nov 27; 104(22):2734-9.Circulation2001-11-27T00:00:002001Ventricular arrhythmia vulnerability in cardiomyopathic mice with homozygous mutant Myosin-binding protein C gene.Authorship 3209808Authorship 321059826913679Rababa'h AM, Deo SV, Altarabsheh SE, De Caro J, Tarboush NA, Alzoubi KH, Ababneh M, McConnell BK, Markowitz AH, Park SJThe heart surgery forumN-Acetyl Cysteine Therapy Does Not Prevent Renal Failure in High-Risk Patients Undergoing Open-Heart Surgery. Heart Surg Forum. 2016 Feb 22; 19(1):E16-22.Heart Surg Forum2016-02-22T00:00:002016N-Acetyl Cysteine Therapy Does Not Prevent Renal Failure in High-Risk Patients Undergoing Open-Heart Surgery.26935106Valenzuela N, Fan Q, Fa'ak F, Soibam B, Nagandla H, Liu Y, Schwartz RJ, McConnell BK, Stewart MDDisease models & mechanismsCardiomyocyte-specific conditional knockout of the histone chaperone HIRA in mice results in hypertrophy, sarcolemmal damage and focal replacement fibrosis. Dis Model Mech. 2016 Mar; 9(3):335-45.Dis Model Mech2016-03-01T00:00:002016Cardiomyocyte-specific conditional knockout of the histone chaperone HIRA in mice results in hypertrophy, sarcolemmal damage and focal replacement fibrosis.Authorship 3257602Authorship 3257731627520666Palmer BM, McConnell BK, Li GH, Seidman CE, Seidman JG, Irving TC, Alpert NR, Maughan DWMolecular and cellular biochemistryReduced cross-bridge dependent stiffness of skinned myocardium from mice lacking cardiac myosin binding protein-C. Mol Cell Biochem. 2004 Aug; 263(1):73-80.Mol Cell Biochem2004-08-01T00:00:002004Reduced cross-bridge dependent stiffness of skinned myocardium from mice lacking cardiac myosin binding protein-C.27538477Liu Y, Chen L, Diaz AD, Benham A, Xu X, Wijaya CS, Fa'ak F, Luo W, Soibam B, Azares A, Yu W, Lyu Q, Stewart MD, Gunaratne P, Cooney A, McConnell BK, Schwartz RJScientific reportsMesp1 Marked Cardiac Progenitor Cells Repair Infarcted Mouse Hearts. Sci Rep. 2016 08 19; 6:31457.Sci Rep2016-08-19T00:00:002016Mesp1 Marked Cardiac Progenitor Cells Repair Infarcted Mouse Hearts.15524168Palmer BM, McConnell BK, Li GH, Seidman CE, Seidman JG, Irving TC, Alpert NR, Maughan DWMolecular and cellular biochemistryReduced cross-bridge dependent stiffness of skinned myocardium from mice lacking cardiac myosin binding protein-C. Mol Cell Biochem. 2004 Aug; 263(1-2):73-80.Mol Cell Biochem2004-08-01T00:00:002004Reduced cross-bridge dependent stiffness of skinned myocardium from mice lacking cardiac myosin binding protein-C.Health 2 4849 Calhoun Road, Room 5024Houston, TX 77204-5039Houston77204-5039TX22108711Nguyen VT, Wu Y, Guillory AN, McConnell BK, Fujise K, Huang MHPeptidesDelta-opioid augments cardiac contraction through ?-adrenergic and CGRP-receptor co-signaling. Peptides. 2012 Jan; 33(1):77-82.Peptides2011-11-15T00:00:002011Delta-opioid augments cardiac contraction through ?-adrenergic and CGRP-receptor co-signaling.Authorship 651876624701590Motawea HK, Blazek AD, Zirwas MJ, Pleister AP, Ahmed AA, McConnell BK, Chotani MAJournal of cytology & molecular biologyDelocalization of Endogenous A-kinase Antagonizes Rap1-Rho-a2C-Adrenoceptor Signaling in Human Microvascular Smooth Muscle Cells. J Cytol Mol Biol. 2014 Jan 10; 1(1).J Cytol Mol Biol2014-01-10T00:00:002014Delocalization of Endogenous A-kinase Antagonizes Rap1-Rho-a2C-Adrenoceptor Signaling in Human Microvascular Smooth Muscle Cells.21562974Huang MH, Wu Y, Nguyen V, Rastogi S, McConnell BK, Wijaya C, Uretsky BF, Poh KK, Tan HC, Fujise KCardiovascular drugs and therapyHeart protection by combination therapy with esmolol and milrinone at late-ischemia and early reperfusion. Cardiovasc Drugs Ther. 2011 Jun; 25(3):223-32.Cardiovasc Drugs Ther2011-06-01T00:00:002011Heart protection by combination therapy with esmolol and milrinone at late-ischemia and early reperfusion.Authorship 869178828428008Li Z, Singh S, Suryavanshi SV, Ding W, Shen X, Wijaya CS, Gao WD, McConnell BKEuropean journal of pharmacologyForce development and intracellular Ca2+ in intact cardiac muscles from gravin mutant mice. Eur J Pharmacol. 2017 Jul 15; 807:117-126.Eur J Pharmacol2017-04-17T00:00:002017Force development and intracellular Ca2+ in intact cardiac muscles from gravin mutant mice.10330263Kim SJ, Iizuka K, Kelly RA, Geng YJ, Bishop SP, Yang G, Kudej A, McConnell BK, Seidman CE, Seidman JG, Vatner SFThe American journal of physiologyAn alpha-cardiac myosin heavy chain gene mutation impairs contraction and relaxation function of cardiac myocytes. Am J Physiol. 1999 05; 276(5):H1780-7.Am J Physiol1999-05-01T00:00:001999An alpha-cardiac myosin heavy chain gene mutation impairs contraction and relaxation function of cardiac myocytes.10606631McConnell BK, Jones KA, Fatkin D, Arroyo LH, Lee RT, Aristizabal O, Turnbull DH, Georgakopoulos D, Kass D, Bond M, Niimura H, Schoen FJ, Conner D, Fischman DA, Seidman CE, Seidman JGThe Journal of clinical investigationDilated cardiomyopathy in homozygous myosin-binding protein-C mutant mice J Clin Invest. 1999 Dec; 104(12):1771.J Clin Invest1999-12-01T00:00:001999Dilated cardiomyopathy in homozygous myosin-binding protein-C mutant mice12639992Song Q, Schmidt AG, Hahn HS, Carr AN, Frank B, Pater L, Gerst M, Young K, Hoit BD, McConnell BK, Haghighi K, Seidman CE, Seidman JG, Dorn GW, Kranias EGThe Journal of clinical investigationRescue of cardiomyocyte dysfunction by phospholamban ablation does not prevent ventricular failure in genetic hypertrophy. J Clin Invest. 2003 Mar; 111(6):859-67.J Clin Invest2003-03-01T00:00:002003Rescue of cardiomyocyte dysfunction by phospholamban ablation does not prevent ventricular failure in genetic hypertrophy.18945669McConnell BK, Popovic Z, Mal N, Lee K, Bautista J, Forudi F, Schwartzman R, Jin JP, Penn M, Bond MThe Journal of biological chemistryDisruption of protein kinase A interaction with A-kinase-anchoring proteins in the heart in vivo: effects on cardiac contractility, protein kinase A phosphorylation, and troponin I proteolysis. J Biol Chem. 2009 Jan 16; 284(3):1583-92.J Biol Chem2008-10-21T00:00:002008Disruption of protein kinase A interaction with A-kinase-anchoring proteins in the heart in vivo: effects on cardiac contractility, protein kinase A phosphorylation, and troponin I proteolysis.21372786Wu Y, Yin X, Wijaya C, Huang MH, McConnell BKJournal of visualized experiments : JoVEAcute myocardial infarction in rats. J Vis Exp. 2011 Feb 16; (48).J Vis Exp2011-02-16T00:00:002011Acute myocardial infarction in rats.Authorship 8818953Authorship 884107629370121Suryavanshi SV, Jadhav SM, McConnell BKJournal of cardiovascular development and diseasePolymorphisms/Mutations in A-Kinase Anchoring Proteins (AKAPs): Role in the Cardiovascular System. J Cardiovasc Dev Dis. 2018 Jan 25; 5(1).J Cardiovasc Dev Dis2018-01-25T00:00:002018Polymorphisms/Mutations in A-Kinase Anchoring Proteins (AKAPs): Role in the Cardiovascular System.29600899Suryavanshi SV, Jadhav SM, Anderson KL, Katsonis P, Lichtarge O, McConnell BKAmerican journal of physiology. Heart and circulatory physiologyHuman muscle-specific A-kinase anchoring protein polymorphisms modulate the susceptibility to cardiovascular diseases by altering cAMP/PKA signaling. Am J Physiol Heart Circ Physiol. 2018 07 01; 315(1):H109-H121.Am J Physiol Heart Circ Physiol2018-03-30T00:00:002018Human muscle-specific A-kinase anchoring protein polymorphisms modulate the susceptibility to cardiovascular diseases by altering cAMP/PKA signaling.true1Associate ProfessorAssociate Professortrue1ProfessorProfessortrue1ProfessorProfessortrue1ProfessorProfessortrue1Associate ProfessorAssociate ProfessorAuthorship 1025202D054758Chemicals & Drugs13220.969936A Kinase Anchor ProteinsD018797Chemicals & Drugs70720460.514576Cell Cycle ProteinsD017868Chemicals & Drugs1342360.90751Cyclic AMP-Dependent Protein KinasesD009206Anatomy39714710.576324MyocardiumAuthorship 9290995Authorship 929456529959870Raghunathan S, Reynolds CL, Schwartz RJ, Stewart MD, McConnell BKFundamental & clinical pharmacologyC.B-17 SCID mice develop epicardial calcinosis with unaltered cardiac function. Fundam Clin Pharmacol. 2019 Feb; 33(1):25-30.Fundam Clin Pharmacol2018-08-05T00:00:002018C.B-17 SCID mice develop epicardial calcinosis with unaltered cardiac function.30451833Zhang P, Guan Y, Chen J, Li X, McConnell BK, Zhou W, Boini KM, Zhang YCell death & diseaseContribution of p62/SQSTM1 to PDGF-BB-induced myofibroblast-like phenotypic transition in vascular smooth muscle cells lacking Smpd1 gene. Cell Death Dis. 2018 11 19; 9(12):1145.Cell Death Dis2018-11-19T00:00:002018Contribution of p62/SQSTM1 to PDGF-BB-induced myofibroblast-like phenotypic transition in vascular smooth muscle cells lacking Smpd1 gene.D000242Chemicals & Drugs1803560.90249Cyclic AMP2019-03-31NIHMCCONNELL, BRADLEY K2015-04-01Scaffolding Protein Interaction Network Regulates Cardiac Cell SignalingR15HL1244582014-03-31NIHMCCONNELL, BRADLEY K2007-09-30Targeted Disruption of Beta-Adrenergic Signaling to Increase Cardiac ContractilitR01HL0854872017-03-31NIHMCCONNELL, BRADLEY K2013-01-17Molecular Mechanism of Dilated CardiomyopathyR15HL117034Principal InvestigatorPrincipal InvestigatorPharmacological & Pharmaceutical SciencesDepartment of MedicineDepartment of Molecular & Cellular BiologyDepartment of Molecular & Human GeneticsMedicine-Athero & LipoproteinsMedicine-CardiologyMedicine-Cardiovascular ScienceMedicine-EndocrinologyMolecular & Cellular BiologyMolecular & Human GeneticsMolecular Physiology & BiophysicsBaylor College of MedicineUniversity of Houston College of PharmacyYOCHAIBIRNBAUMYOCHAI BIRNBAUM0.000000000000000.000000000000001504BIRNBAUM, YOCHAIProfessorNIKOLAOSFRANGOGIANNISNIKOLAOS FRANGOGIANNIS29.70508570000000-95.401808700000001993FRANGOGIANNIS, NIKOLAOSAdjunct ProfessorROBERTSCHWARTZROBERT SCHWARTZ0.000000000000000.000000000000002506SCHWARTZ, ROBERTAdjunct ProfessorKARIMALKADHIKARIM A. ALKADHI29.72602660000000-95.348164100000004613ALKADHI, KARIMProfessorRICHARDBONDRICHARD A. BOND29.72602660000000-95.348164100000004618BOND, RICHARDProfessorPREETHIGUNARATNEPREETHI GUNARATNE0.000000000000000.000000000000003337GUNARATNE, PREETHIAdjunct Associate ProfessorSALIMVIRANISALIM VIRANI29.70978600000000-95.399866000000003676VIRANI, SALIMAdjunct ProfessorHEINRICHTAEGTMEYERHEINRICH TAEGTMEYER29.70508570000000-95.401808700000004081TAEGTMEYER, HEINRICHAdjunct ProfessorJOYDIPDASJOYDIP DAS29.72602660000000-95.348164100000004622DAS, JOYDIPAssociate ProfessorGREGCUNYGREG D. CUNY29.72602660000000-95.348164100000004593CUNY, GREGAssociate Professor4.464830.00428721294research areas1.908740.043135610coauthor of54.34156.210660similar to1147selected publicationsOLIVIERLICHTARGEOLIVIER LICHTARGE0.000000000000000.000000000000003574LICHTARGE, OLIVIERProfessorTAHIRHUSSAINTAHIR HUSSAIN29.72602660000000-95.348164100000004617HUSSAIN, TAHIRProfessor. Associate Dean for Research and Graduate ProgramsXANDERWEHRENSXANDER WEHRENS0.000000000000000.00000000000000964WEHRENS, XANDERProfessor2022-03-31NIHMCCONNELL, BRADLEY K2019-04-01Gravin Signalosome Protein Coordinates Cardiac Function via Adrenergic Receptor SignalingR15HL141963Principal InvestigatorAuthorship 12677410Authorship 129184923806656Rababa'h A, Craft JW, Wijaya CS, Atrooz F, Fan Q, Singh S, Guillory AN, Katsonis P, Lichtarge O, McConnell BKJournal of molecular biologyProtein kinase A and phosphodiesterase-4D3 binding to coding polymorphisms of cardiac muscle anchoring protein (mAKAP). J Mol Biol. 2013 Sep 23; 425(18):3277-88.J Mol Biol2013-06-25T00:00:002013Protein kinase A and phosphodiesterase-4D3 binding to coding polymorphisms of cardiac muscle anchoring protein (mAKAP).24058627Guillory AN, Yin X, Wijaya CS, Diaz Diaz AC, Rababa'h A, Singh S, Atrooz F, Sadayappan S, McConnell BKPloS oneEnhanced cardiac function in Gravin mutant mice involves alterations in the ?-adrenergic receptor signaling cascade. PLoS One. 2013; 8(9):e74784.PLoS One2013-09-18T00:00:002013Enhanced cardiac function in Gravin mutant mice involves alterations in the ?-adrenergic receptor signaling cascade.Authorship 9543191131441691Fan Q, Yin X, Rababa'h A, Diaz Diaz A, Wijaya CS, Singh S, Suryavanshi SV, Vo HH, Saeed M, Zhang Y, McConnell BKAmerican journal of physiology. Heart and circulatory physiologyAbsence of gravin-mediated signaling inhibits development of high-fat diet-induced hyperlipidemia and atherosclerosis. Am J Physiol Heart Circ Physiol. 2019 10 01; 317(4):H793-H810.Am J Physiol Heart Circ Physiol2019-08-23T00:00:002019Absence of gravin-mediated signaling inhibits development of high-fat diet-induced hyperlipidemia and atherosclerosis.Authorship 955445431515484Wang YT, Li X, Chen J, McConnell BK, Chen L, Li PL, Chen Y, Zhang YCell death & diseaseActivation of TFEB ameliorates dedifferentiation of arterial smooth muscle cells and neointima formation in mice with high-fat diet. Cell Death Dis. 2019 09 12; 10(9):676.Cell Death Dis2019-09-12T00:00:002019Activation of TFEB ameliorates dedifferentiation of arterial smooth muscle cells and neointima formation in mice with high-fat diet.79Professor. Associate Dean for Research and Graduate Programstrue1Professor. Associate Dean for Research and Graduate ProgramsProfessor. Associate Dean for Research and Graduate Programstrue1Associate ProfessorAssociate ProfessorAuthorship 960438831678351Raghunathan S, Islas JF, Mistretta B, Iyer D, Shi L, Gunaratne PH, Ko G, Schwartz RJ, McConnell BKJournal of molecular and cellular cardiologyConversion of human cardiac progenitor cells into cardiac pacemaker-like cells. J Mol Cell Cardiol. 2020 01; 138:12-22.J Mol Cell Cardiol2019-10-31T00:00:002019Conversion of human cardiac progenitor cells into cardiac pacemaker-like cells.Authorship 975361631914652Roberston MJ, Raghunathan S, Potaman VN, Zhang F, Stewart MD, McConnell BK, Schwartz RJFASEB journal : official publication of the Federation of American Societies for Experimental BiologyCRISPR-Cas9-induced IGF1 gene activation as a tool for enhancing muscle differentiation via multiple isoform expression. FASEB J. 2020 01; 34(1):555-570.FASEB J2019-11-25T00:00:002019CRISPR-Cas9-induced IGF1 gene activation as a tool for enhancing muscle differentiation via multiple isoform expression.PANAGIOTISKATSONISPANAGIOTIS KATSONIS0.000000000000000.000000000000005889KATSONIS, PANAGIOTISAssistant ProfessorAuthorship 986114232224038Schwartz RJ, McConnell BKJournal of molecular and cellular cardiologyResponse to Zhao and Huang's Commentary Letter, "Conversion of Human Cardiac Progenitor Cells using Reprogramming Factors into Heterogeneous Cardiac Pacemaker-like Cells", regarding our Manuscript: "Conversion of Human Cardiac Progenitor Cells into Cardiac Pacemaker-like Cells". J Mol Cell Cardiol. 2020 04; 141:105-106.J Mol Cell Cardiol2020-03-26T00:00:002020Response to Zhao and Huang's Commentary Letter, "Conversion of Human Cardiac Progenitor Cells using Reprogramming Factors into Heterogeneous Cardiac Pacemaker-like Cells", regarding our Manuscript: "Conversion of Human Cardiac Progenitor Cells into Cardiac Pacemaker-like Cells".Authorship 992504232573313Qasim H, McConnell BKJournal of the American Heart AssociationAKAP12 Signaling Complex: Impacts of Compartmentalizing cAMP-Dependent Signaling Pathways in the Heart and Various Signaling Systems. J Am Heart Assoc. 2020 07 07; 9(13):e016615.J Am Heart Assoc2020-06-23T00:00:002020AKAP12 Signaling Complex: Impacts of Compartmentalizing cAMP-Dependent Signaling Pathways in the Heart and Various Signaling Systems.true1Assistant ProfessorAssistant ProfessorAuthorship 11602110Principal InvestigatorAuthorship 10325581734704401Liang R, Shen X, Wang F, Wang X, DesJarlais A, Syed A, Saba R, Tan Z, Yu F, Ji X, Shrestha S, Ren Y, Yang J, Park Y, Schwartz RJ, Soibam B, McConnell BK, Stewart MD, Kumar A, Liu YJournal of cachexia, sarcopenia and muscleH19X-encoded miR-322(424)/miR-503 regulates muscle mass by targeting translation initiation factors. J Cachexia Sarcopenia Muscle. 2021 12; 12(6):2174-2186.J Cachexia Sarcopenia Muscle2021-10-26T00:00:002021H19X-encoded miR-322(424)/miR-503 regulates muscle mass by targeting translation initiation factors.true1Adjunct Associate ProfessorAdjunct Associate ProfessorAuthorship 10380136Authorship 10397721135260793Reyes-Alcaraz A, Lucero Garcia-Rojas EY, Merlinsky EA, Seong JY, Bond RA, McConnell BKCommunications biologyA NanoBiT assay to monitor membrane proteins trafficking for drug discovery and drug development. Commun Biol. 2022 03 08; 5(1):212.Commun Biol2022-03-08T00:00:002022A NanoBiT assay to monitor membrane proteins trafficking for drug discovery and drug development.35149557Bagchi RA, Robinson EL, Hu T, Cao J, Hong JY, Tharp CA, Qasim H, Gavin KM, Pires da Silva J, Major JL, McConnell BK, Seto E, Lin H, McKinsey TAProceedings of the National Academy of Sciences of the United States of AmericaReversible lysine fatty acylation of an anchoring protein mediates adipocyte adrenergic signaling. Proc Natl Acad Sci U S A. 2022 02 15; 119(7).Proc Natl Acad Sci U S A2022-02-15T00:00:002022Reversible lysine fatty acylation of an anchoring protein mediates adipocyte adrenergic signaling.Authorship 1051479435891703Xiao S, Liang R, Lucero E, McConnell BK, Chen Z, Chang J, Navran S, Schwartz RJ, Iyer DThe journal of cardiovascular agingSTEMIN and YAP5SA synthetic modified mRNAs regenerate and repair infarcted mouse hearts. J Cardiovasc Aging. 2022 Jul; 2(3).J Cardiovasc Aging2022-06-15T00:00:002022STEMIN and YAP5SA synthetic modified mRNAs regenerate and repair infarcted mouse hearts.true1ProfessorProfessorDepartment of Integrative PhysiologyAuthorship 105895312Authorship 1061249436479208Lucero-Garcia Rojas EY, Reyes-Alcaraz A, Ruan K, McConnell BK, Bond RAFASEB bioAdvancesFusion of the ?2-adrenergic receptor with either Gas or ?arrestin-2 produces constitutive signaling by each pathway and induces gain-of-function in BEAS-2B cells. FASEB Bioadv. 2022 Dec; 4(12):758-774.FASEB Bioadv2022-09-24T00:00:002022Fusion of the ?2-adrenergic receptor with either Gas or ?arrestin-2 produces constitutive signaling by each pathway and induces gain-of-function in BEAS-2B cells.36388958Prodan N, Ershad F, Reyes-Alcaraz A, Li L, Mistretta B, Gonzalez L, Rao Z, Yu C, Gunaratne PH, Li N, Schwartz RJ, McConnell BKiScienceDirect reprogramming of cardiomyocytes into cardiac Purkinje-like cells. iScience. 2022 Nov 18; 25(11):105402.iScience2022-10-20T00:00:002022Direct reprogramming of cardiomyocytes into cardiac Purkinje-like cells.true1Adjunct ProfessorAdjunct ProfessorAuthorship 1066912936979895Reyes-Alcaraz A, Qasim H, Merlinsky E, Fox G, Islam T, Medina B, Schwartz RJ, Craft JW, McConnell BKBiomedicinesA Small Molecule That In Vitro Neutralizes Infection of SARS-CoV-2 and Its Most Infectious Variants, Delta, and Omicron. Biomedicines. 2023 Mar 15; 11(3).Biomedicines2023-03-15T00:00:002023A Small Molecule That In Vitro Neutralizes Infection of SARS-CoV-2 and Its Most Infectious Variants, Delta, and Omicron.true1Adjunct ProfessorAdjunct Professortrue1Adjunct ProfessorAdjunct Professortrue1Adjunct ProfessorAdjunct ProfessorAuthorship 10720631537283844Arao Y, Gruzdev A, Scott GJ, Ray MK, Donoghue LJ, Neufeld TI, Lierz SL, Stefkovich ML, Mathura E, Jefferson T, Foley JF, Mahler BW, Asghari A, Le C, McConnell BK, Stephen R, Berridge BR, Hamilton KJ, Hewitt SC, Umetani M, Korach KSJournal of the Endocrine SocietyA Novel Mouse Model to Analyze Non-Genomic ERa Physiological Actions. J Endocr Soc. 2022 Sep 01; 6(9):bvac109.J Endocr Soc2022-07-26T00:00:002022A Novel Mouse Model to Analyze Non-Genomic ERa Physiological Actions.true1ProfessorProfessorAuthorship 1090921938506047Qasim H, Rajaei M, Xu Y, Reyes-Alcaraz A, Abdelnasser HY, Stewart MD, Lahiri SK, Wehrens XHT, McConnell BKCirculation researchAKAP12 Upregulation Associates With PDE8A to Accelerate Cardiac Dysfunction. Circ Res. 2024 Mar 20.Circ Res2024-03-20T00:00:002024AKAP12 Upregulation Associates With PDE8A to Accelerate Cardiac Dysfunction.Authorship 269723Authorship 452512Authorship 4134Authorship 574955