KE-HE RUAN to Intramolecular Oxidoreductases
This is a "connection" page, showing publications KE-HE RUAN has written about Intramolecular Oxidoreductases.
Connection Strength
4.470
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Engineering 'Enzymelink' for screening lead compounds to inhibit mPGES-1 while maintaining prostacyclin synthase activity. Future Med Chem. 2021 07; 13(13):1091-1103.
Score: 0.741
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Relationship of the Topological Distances and Activities between mPGES-1 and COX-2 versus COX-1: Implications of the Different Post-Translational Endoplasmic Reticulum Organizations of COX-1 and COX-2. Biochemistry. 2015 Jun 16; 54(23):3707-15.
Score: 0.489
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Resistant to thrombosis, induced stroke and heart arrest by incorporation of a single gene of PGI2-synthesizing COX-1-PGIS in vivo: Implication against human heart disease. Int J Cardiol. 2013 Oct 03; 168(3):2960-1.
Score: 0.422
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An active triple-catalytic hybrid enzyme engineered by linking cyclo-oxygenase isoform-1 to prostacyclin synthase that can constantly biosynthesize prostacyclin, the vascular protector. FEBS J. 2008 Dec; 275(23):5820-9.
Score: 0.311
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Large-scale expression, purification, and characterization of an engineered prostacyclin-synthesizing enzyme with therapeutic potential. Arch Biochem Biophys. 2008 Dec 01; 480(1):41-50.
Score: 0.307
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Characterization of the substrate mimic bound to engineered prostacyclin synthase in solution using high-resolution NMR spectroscopy and mutagenesis: implication of the molecular mechanism in biosynthesis of prostacyclin. Biochemistry. 2008 Jan 15; 47(2):680-8.
Score: 0.291
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Engineering of a protein with cyclooxygenase and prostacyclin synthase activities that converts arachidonic acid to prostacyclin. Biochemistry. 2006 Nov 28; 45(47):14003-11.
Score: 0.271
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The N-terminal membrane anchor domain of the membrane-bound prostacyclin synthase involved in the substrate presentation of the coupling reaction with cyclooxygenase. Arch Biochem Biophys. 2005 Mar 15; 435(2):372-81.
Score: 0.241
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Identification of the residues in the helix F/G loop important to catalytic function of membrane-bound prostacyclin synthase. Biochemistry. 2003 May 20; 42(19):5609-17.
Score: 0.212
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Determination of the membrane contact residues and solution structure of the helix F/G loop of prostaglandin I2 synthase. Arch Biochem Biophys. 2003 Mar 01; 411(1):27-35.
Score: 0.209
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Solution structure and topology of the N-terminal membrane anchor domain of a microsomal cytochrome P450: prostaglandin I2 synthase. Biochem J. 2002 Dec 15; 368(Pt 3):721-8.
Score: 0.206
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Substrate access channel topology in membrane-bound prostacyclin synthase. Biochem J. 2002 Mar 15; 362(Pt 3):545-51.
Score: 0.196
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Creating a mouse model resistant to induced ischemic stroke and cardiovascular damage. Sci Rep. 2018 01 26; 8(1):1653.
Score: 0.147
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COX-2-10aa-PGIS gene therapy improves erectile function in rats after cavernous nerve injury. J Sex Med. 2013 Jun; 10(6):1476-87.
Score: 0.105
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Prostacyclin therapy for pulmonary arterial hypertension. Tex Heart Inst J. 2010; 37(4):391-9.
Score: 0.084
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Engineering of a novel hybrid enzyme: an anti-inflammatory drug target with triple catalytic activities directly converting arachidonic acid into the inflammatory prostaglandin E2. Protein Eng Des Sel. 2009 Dec; 22(12):733-40.
Score: 0.083
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Implications of the molecular basis of prostacyclin biosynthesis and signaling in pharmaceutical designs. Curr Pharm Des. 2006; 12(8):925-41.
Score: 0.064
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Elevated prostacyclin biosynthesis in mice impacts memory and anxiety-like behavior. Behav Brain Res. 2014 Jan 01; 258:138-44.
Score: 0.027
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Endothelial-like progenitor cells engineered to produce prostacyclin rescue monocrotaline-induced pulmonary arterial hypertension and provide right ventricle benefits. Circulation. 2013 Aug 27; 128(9):982-94.
Score: 0.027
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Engineered endothelial progenitor cells that overexpress prostacyclin protect vascular cells. J Cell Physiol. 2012 Jul; 227(7):2907-16.
Score: 0.025
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Prostacyclin is an autocrine regulator in the contraction of oviductal smooth muscle. Hum Reprod. 2002 Dec; 17(12):3053-9.
Score: 0.013