KE-HE RUAN to Humans
This is a "connection" page, showing publications KE-HE RUAN has written about Humans.
Connection Strength
0.349
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Reprogramming Megakaryocytes for Controlled Release of Platelet-like Particles Carrying a Single-Chain Thromboxane A2 Receptor-G-Protein Complex with Therapeutic Potential. Cells. 2023 12 06; 12(24).
Score: 0.019
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Recent advances of cannabidiol studies in medicinal chemistry, pharmacology and therapeutics. Future Med Chem. 2021 11; 13(22):1935-1937.
Score: 0.016
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Engineering 'Enzymelink' for screening lead compounds to inhibit mPGES-1 while maintaining prostacyclin synthase activity. Future Med Chem. 2021 07; 13(13):1091-1103.
Score: 0.016
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Redirecting thromboxane A2 and prostacyclin biosyntheses from thrombotic to antithrombotic property by an Enzymelink. Future Med Chem. 2021 05; 13(9):765-768.
Score: 0.016
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A novel single-chain enzyme complex with chain reaction properties rapidly producing thromboxane A2 and exhibiting powerful anti-bleeding functions. J Cell Mol Med. 2019 12; 23(12):8343-8354.
Score: 0.014
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Recent advances and near future of insulin production and therapy. Future Med Chem. 2019 07; 11(13):1513-1517.
Score: 0.014
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Advances in extracellular ligand recognition sites on prostanoid receptors. Future Med Chem. 2018 05 01; 10(9):979-981.
Score: 0.013
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The key residue within the second extracellular loop of human EP3 involved in selectively turning down PGE2- and retaining PGE1-mediated signaling in live cells. Arch Biochem Biophys. 2017 02 15; 616:20-29.
Score: 0.012
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How can we address the controversies surrounding the use of NSAIDS in neurodegeneration? Future Med Chem. 2016 07; 8(11):1153-5.
Score: 0.011
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How can we target oxidative stress in the treatment of neurodegenerative diseases? Future Med Chem. 2016 05; 8(8):835-9.
Score: 0.011
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Identification of the two-phase mechanism of arachidonic acid regulating inflammatory prostaglandin E2 biosynthesis by targeting COX-2 and mPGES-1. Arch Biochem Biophys. 2016 08 01; 603:29-37.
Score: 0.011
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Relationship of the Topological Distances and Activities between mPGES-1 and COX-2 versus COX-1: Implications of the Different Post-Translational Endoplasmic Reticulum Organizations of COX-1 and COX-2. Biochemistry. 2015 Jun 16; 54(23):3707-15.
Score: 0.010
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Resistant to thrombosis, induced stroke and heart arrest by incorporation of a single gene of PGI2-synthesizing COX-1-PGIS in vivo: Implication against human heart disease. Int J Cardiol. 2013 Oct 03; 168(3):2960-1.
Score: 0.009
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Establishing novel prostacyclin-synthesizing cells with therapeutic potential against heart diseases. Int J Cardiol. 2013 Feb 20; 163(2):163-9.
Score: 0.008
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Novel mechanism of the vascular protector prostacyclin: regulating microRNA expression. Biochemistry. 2011 Mar 15; 50(10):1691-9.
Score: 0.008
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An agonist sensitive, quick and simple cell-based signaling assay for determination of ligands mimicking prostaglandin E2 or E1 activity through subtype EP1 receptor: Suitable for high throughput screening. BMC Complement Altern Med. 2011 Feb 07; 11:11.
Score: 0.008
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Structural and functional analysis of the C-terminus of Galphaq in complex with the human thromboxane A2 receptor provides evidence of constitutive activity. Biochemistry. 2010 Aug 03; 49(30):6365-74.
Score: 0.007
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A profile of NSAID-targeted arachidonic acid metabolisms in human embryonic stem cells (hESCs): implication of the negative effects of NSAIDs on heart tissue regeneration. Int J Cardiol. 2011 Aug 04; 150(3):253-9.
Score: 0.007
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Prostacyclin therapy for pulmonary arterial hypertension. Tex Heart Inst J. 2010; 37(4):391-9.
Score: 0.007
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Engineering of a novel hybrid enzyme: an anti-inflammatory drug target with triple catalytic activities directly converting arachidonic acid into the inflammatory prostaglandin E2. Protein Eng Des Sel. 2009 Dec; 22(12):733-40.
Score: 0.007
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Ligand-specific conformation determines agonist activation and antagonist blockade in purified human thromboxane A2 receptor. Biochemistry. 2009 Apr 14; 48(14):3157-65.
Score: 0.007
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An active triple-catalytic hybrid enzyme engineered by linking cyclo-oxygenase isoform-1 to prostacyclin synthase that can constantly biosynthesize prostacyclin, the vascular protector. FEBS J. 2008 Dec; 275(23):5820-9.
Score: 0.007
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Large-scale expression, purification, and characterization of an engineered prostacyclin-synthesizing enzyme with therapeutic potential. Arch Biochem Biophys. 2008 Dec 01; 480(1):41-50.
Score: 0.007
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Involvement of non-conserved residues important for PGE2 binding to the constrained EP3 eLP2 using NMR and site-directed mutagenesis. FEBS Lett. 2008 Aug 20; 582(19):2863-8.
Score: 0.006
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Characterization of the prostaglandin H2 mimic: binding to the purified human thromboxane A2 receptor in solution. Arch Biochem Biophys. 2008 Sep 15; 477(2):396-403.
Score: 0.006
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A simple, quick, and high-yield preparation of the human thromboxane A2 receptor in full size for structural studies. Biochemistry. 2008 Jul 01; 47(26):6819-26.
Score: 0.006
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Characterization of the substrate mimic bound to engineered prostacyclin synthase in solution using high-resolution NMR spectroscopy and mutagenesis: implication of the molecular mechanism in biosynthesis of prostacyclin. Biochemistry. 2008 Jan 15; 47(2):680-8.
Score: 0.006
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Assembling NMR structures for the intracellular loops of the human thromboxane A2 receptor: implication of the G protein-coupling pocket. Arch Biochem Biophys. 2008 Feb 01; 470(1):73-82.
Score: 0.006
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A profile of the residues in the second extracellular loop that are critical for ligand recognition of human prostacyclin receptor. FEBS J. 2008 Jan; 275(1):128-37.
Score: 0.006
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Engineering of a protein with cyclooxygenase and prostacyclin synthase activities that converts arachidonic acid to prostacyclin. Biochemistry. 2006 Nov 28; 45(47):14003-11.
Score: 0.006
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Prunella stica inhibits the proliferation but not the prostaglandin production of Ishikawa cells. Life Sci. 2006 Jun 27; 79(5):436-41.
Score: 0.005
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Implications of the molecular basis of prostacyclin biosynthesis and signaling in pharmaceutical designs. Curr Pharm Des. 2006; 12(8):925-41.
Score: 0.005
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A strategy using NMR peptide structures of thromboxane A2 receptor as templates to construct ligand-recognition pocket of prostacyclin receptor. BMC Biochem. 2005 Nov 04; 6:23.
Score: 0.005
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A profile of the residues in the first intracellular loop critical for Gs-mediated signaling of human prostacyclin receptor characterized by an integrative approach of NMR-experiment and mutagenesis. Biochemistry. 2005 Aug 30; 44(34):11389-401.
Score: 0.005
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Advance in understanding the biosynthesis of prostacyclin and thromboxane A2 in the endoplasmic reticulum membrane via the cyclooxygenase pathway. Mini Rev Med Chem. 2004 Aug; 4(6):639-47.
Score: 0.005
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NMR structure of the thromboxane A2 receptor ligand recognition pocket. Eur J Biochem. 2004 Jul; 271(14):3006-16.
Score: 0.005
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Structural and functional characterization of the first intracellular loop of human thromboxane A2 receptor. Arch Biochem Biophys. 2004 Mar 15; 423(2):253-65.
Score: 0.005
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Evidence of the residues involved in ligand recognition in the second extracellular loop of the prostacyclin receptor characterized by high resolution 2D NMR techniques. Arch Biochem Biophys. 2003 Oct 01; 418(1):25-33.
Score: 0.005
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Solution structure of the third extracellular loop of human thromboxane A2 receptor. Arch Biochem Biophys. 2003 Jun 15; 414(2):287-93.
Score: 0.005
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Identification of the residues in the helix F/G loop important to catalytic function of membrane-bound prostacyclin synthase. Biochemistry. 2003 May 20; 42(19):5609-17.
Score: 0.005
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Physical and functional antagonism between tumor suppressor protein p53 and fortilin, an anti-apoptotic protein. J Biol Chem. 2011 Sep 16; 286(37):32575-85.
Score: 0.002
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The short-neurotoxin-binding regions on the alpha-chain of human and Torpedo californica acetylcholine receptors. Biochem J. 1991 Mar 15; 274 ( Pt 3):849-54.
Score: 0.002
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Acetylcholine receptor-alpha-bungarotoxin interactions: determination of the region-to-region contacts by peptide-peptide interactions and molecular modeling of the receptor cavity. Proc Natl Acad Sci U S A. 1990 Aug; 87(16):6156-60.
Score: 0.002
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A new strategy, SuperEnzyme gene therapy in penile rehabilitation. J Sex Med. 2009 Mar; 6 Suppl 3:328-33.
Score: 0.002
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Characterization of the molecular mechanisms of the coupling between intracellular loops of prostacyclin receptor with the C-terminal domain of the Galphas protein in human coronary artery smooth muscle cells. Arch Biochem Biophys. 2006 Oct 01; 454(1):80-8.
Score: 0.001
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From the design to the clinical application of thromboxane modulators. Curr Pharm Des. 2006; 12(8):903-23.
Score: 0.001
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New developments on thromboxane and prostacyclin modulators part I: thromboxane modulators. Curr Med Chem. 2004 May; 11(10):1223-41.
Score: 0.001
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Role of Val509 in time-dependent inhibition of human prostaglandin H synthase-2 cyclooxygenase activity by isoform-selective agents. J Biol Chem. 1996 Aug 09; 271(32):19134-9.
Score: 0.001
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Profile of the regions on the alpha-chain of human acetylcholine receptor recognized by autoantibodies in myasthenia gravis. Mol Immunol. 1992 Dec; 29(12):1507-14.
Score: 0.001
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Primary structure of human thromboxane synthase determined from the cDNA sequence. J Biol Chem. 1992 Jan 15; 267(2):789-93.
Score: 0.001