ROMIGHOSEROMI GHOSE29.70508570000000-95.401808700000004607GHOSE, ROMIAssociate Professorprns:coAuthorOfcoauthor ofprns:endDateend dateFaculty Rankprns:fullNamefull nameprns:grantAwardedBygrant awarded byprns:hasAuthorListauthor listprns:hasFacultyRankhas faculty rankprns:hasNetworkhas networkprns:hasPublicationVenuepublished inprns:informationResourceReferenceinformation resource referenceprns:isPrimaryPositionis primary positionprns:latitudelatitudeprns:longitudelongitudeprns:mainImagephotoprns:maxWeightmaximum weightprns:medlineTAjournal title abbreviationprns:meshDescriptorUIMeSH DescriptorUIprns:meshSemanticGroupNameMeSH semantic group nameprns:minWeightminimum weightprns:numberOfAuthorsnumber of authorsprns:numberOfConnectionsnumber of connectionsprns:numberOfPublicationsnumber of publicationsprns:personIdPerson IDprns:personInPrimaryPositionperson in primary positionprns:physicalNeighborOfphysical neighborprns:positionInDepartmentposition in departmentprns:positionInDivisionposition in divisionprns:predicateNodepredicate nodeprns:principalInvestigatorNameprincipal investigator nameprns:publicationDatepublication dateprns:similarTosimilar toprns:sortOrdersort orderprns:startDatestart dateprns:uniquenessWeightuniqueness weightprns:yearyearAcademic ArticleArticleDocumentbibo:pmidPubMed IdentifierAddressvivo:address1address line 1vivo:address2address line 2vivo:addressCitycityvivo:addressPostalCodepostal codevivo:addressStatestate or provinceAgreementvivo:authorInAuthorshipselected publicationsvivo:authorRankauthor rank in publicationAuthorshipDepartmentDivisionGrantvivo:hasResearchArearesearch areasvivo:hasResearcherRoleresearch activitiesvivo:hrJobTitleHR job titleInformation Resourcevivo:linkedAuthorlinked authorvivo:linkedInformationResourcelinked information resourcevivo:mailingAddressmailing addressvivo:personInPositionpositionsPositionvivo:positionInOrganizationposition in organizationvivo:preferredTitlepreferred titleResearcher Rolevivo:researcherRoleOfresearcher role ofRolevivo:roleContributesTocontributes tovivo:sponsorAwardIdsponsor award idrdf:predicatepredicaterdf:typetyperdfs:labellabelConceptAgentfoaf:firstNamefirst namefoaf:lastNamelast nameOrganizationPersonPharmaceutical Health Outcomes and PolicyAuthorship 91Authorship 979591Authorship 1178391Authorship 173066GI Medical OncologyLeukemiaRadiation PhysicsSurgical OncologyMD AndersonJAFFER AAJANIJAFFER A AJANI8473AJANI, JAFFER AProfessorHAGOP MKANTARJIANHAGOP M KANTARJIAN8501KANTARJIAN, HAGOP MProfessorJEAN NICOLASVAUTHEYJEAN NICOLAS VAUTHEY8766VAUTHEY, JEAN NICOLASProfessorSONGGAOSONG GAO9222GAO, SONGAssistant ProfessorAuthorship 43233Authorship 692591Authorship 702951Authorship 2998174Authorship 300978426334566Mallick P, Shah P, Gandhi A, Ghose RLife sciencesImpact of obesity on accumulation of the toxic irinotecan metabolite, SN-38, in mice. Life Sci. 2015 Oct 15; 139:132-8.Life Sci2015-09-01T00:00:002015Impact of obesity on accumulation of the toxic irinotecan metabolite, SN-38, in mice.26470915Shah P, Omoluabi O, Moorthy B, Ghose RDrug metabolism and disposition: the biological fate of chemicalsRole of Adaptor Protein Toll-Like Interleukin Domain Containing Adaptor Inducing Interferon ? in Toll-Like Receptor 3- and 4-Mediated Regulation of Hepatic Drug Metabolizing Enzyme and Transporter Genes. Drug Metab Dispos. 2016 Jan; 44(1):61-7.Drug Metab Dispos2015-10-15T00:00:002015Role of Adaptor Protein Toll-Like Interleukin Domain Containing Adaptor Inducing Interferon ? in Toll-Like Receptor 3- and 4-Mediated Regulation of Hepatic Drug Metabolizing Enzyme and Transporter Genes.Gandhi A and Ghose R. Altered Drug Metabolism and Transport in Pathophysiological Conditions.Altered Drug Metabolism and Transport in Pathophysiological Conditions. 2012.2012-01-01T00:00:002012Altered Drug Metabolism and Transport in Pathophysiological Conditions74Professor10Assistant Professor33Clinical Professor29Clinical Associate Professor14Associate Professor47Distinguished Service ProfessorAuthorship 320967126910068Ghose R, Mallick P, Taneja G, Chu C, Moorthy BMethods in molecular biology (Clifton, N.J.)In Vitro Approaches to Study Regulation of Hepatic Cytochrome P450 (CYP) 3A Expression by Paclitaxel and Rifampicin. Methods Mol Biol. 2016; 1395:55-68.Methods Mol Biol2016-01-01T00:00:002016In Vitro Approaches to Study Regulation of Hepatic Cytochrome P450 (CYP) 3A Expression by Paclitaxel and Rifampicin.17932222Ghose R, White D, Guo T, Vallejo J, Karpen SJDrug metabolism and disposition: the biological fate of chemicalsRegulation of hepatic drug-metabolizing enzyme genes by Toll-like receptor 4 signaling is independent of Toll-interleukin 1 receptor domain-containing adaptor protein. Drug Metab Dispos. 2008 Jan; 36(1):95-101.Drug Metab Dispos2007-10-11T00:00:002007Regulation of hepatic drug-metabolizing enzyme genes by Toll-like receptor 4 signaling is independent of Toll-interleukin 1 receptor domain-containing adaptor protein.14993284Ghose R, Malik M, Huber PWMolecular and cellular biologyRestricted specificity of Xenopus TFIIIA for transcription of somatic 5S rRNA genes. Mol Cell Biol. 2004 Mar; 24(6):2467-77.Mol Cell Biol2004-03-01T00:00:002004Restricted specificity of Xenopus TFIIIA for transcription of somatic 5S rRNA genes.20371967Gandhi A, Guo T, Ghose RThe Journal of toxicological sciencesRole of c-Jun N-terminal kinase (JNK) in regulating tumor necrosis factor-alpha (TNF-alpha) mediated increase of acetaminophen (APAP) and chlorpromazine (CPZ) toxicity in murine hepatocytes. J Toxicol Sci. 2010 Apr; 35(2):163-73.J Toxicol Sci2010-04-01T00:00:002010Role of c-Jun N-terminal kinase (JNK) in regulating tumor necrosis factor-alpha (TNF-alpha) mediated increase of acetaminophen (APAP) and chlorpromazine (CPZ) toxicity in murine hepatocytes.Health 2 4849 Calhoun Road, Room 7045Houston, TX 77204-5037Houston77204-5037TX16551633Zimmerman TL, Thevananther S, Ghose R, Burns AR, Karpen SJThe Journal of biological chemistryNuclear export of retinoid X receptor alpha in response to interleukin-1beta-mediated cell signaling: roles for JNK and SER260. J Biol Chem. 2006 Jun 02; 281(22):15434-40.J Biol Chem2006-03-21T00:00:002006Nuclear export of retinoid X receptor alpha in response to interleukin-1beta-mediated cell signaling: roles for JNK and SER260.Authorship 359821115312234Ghose R, Zimmerman TL, Thevananther S, Karpen SJNuclear receptorEndotoxin leads to rapid subcellular re-localization of hepatic RXRalpha: A novel mechanism for reduced hepatic gene expression in inflammation. Nucl Recept. 2004 Aug 16; 2(1):4.Nucl Recept2004-08-16T00:00:002004Endotoxin leads to rapid subcellular re-localization of hepatic RXRalpha: A novel mechanism for reduced hepatic gene expression in inflammation.22746301Gandhi A, Moorthy B, Ghose RCurrent drug metabolismDrug disposition in pathophysiological conditions. Curr Drug Metab. 2012 Nov; 13(9):1327-44.Curr Drug Metab2012-11-01T00:00:002012Drug disposition in pathophysiological conditions.22763214Fahy BN, Guo T, Ghose RThe Journal of surgical researchImpact of hepatic malignancy on CYP3A4 gene expression. J Surg Res. 2012 Dec; 178(2):768-72.J Surg Res2012-06-21T00:00:002012Impact of hepatic malignancy on CYP3A4 gene expression.18940178Ghose R, Guo T, Haque NArchives of biochemistry and biophysicsRegulation of gene expression of hepatic drug metabolizing enzymes and transporters by the Toll-like receptor 2 ligand, lipoteichoic acid. Arch Biochem Biophys. 2009 Jan 01; 481(1):123-30.Arch Biochem Biophys2008-10-08T00:00:002008Regulation of gene expression of hepatic drug metabolizing enzymes and transporters by the Toll-like receptor 2 ligand, lipoteichoic acid.19631096Tam VH, Ledesma KR, Schilling AN, Lim TP, Yuan Z, Ghose R, Lewis REDiagnostic microbiology and infectious diseaseIn vivo dynamics of carbapenem-resistant Pseudomonas aeruginosa selection after suboptimal dosing. Diagn Microbiol Infect Dis. 2009 Aug; 64(4):427-33.Diagn Microbiol Infect Dis2009-08-01T00:00:002009In vivo dynamics of carbapenem-resistant Pseudomonas aeruginosa selection after suboptimal dosing.Ghose, R., J. Mulder and S. J. Karpen.Lipoplolysaccharide-mediated down-regulation of hepatic genes is ameliorated by the PPAR agonist, Rosiglitazone. J Hepatol. Lipoplolysaccharide-mediated down-regulation of hepatic genes is ameliorated by the PPAR agonist, Rosiglitazone. J Hepatol. 2007; 46(1):115-123.2007-01-01T00:00:002007Lipoplolysaccharide-mediated down-regulation of hepatic genes is ameliorated by the PPAR agonist, Rosiglitazone. J HepatolGandhi A, Shah P, Guo T, Moorthy B, Chow S-L. D, Hu M & Ghose R.Altered pharmacokinetics and pharmacodynamics of the CYP3A substrate, midazolam, during hepatic inflammation induced by bacterial endotoxins. British Journal of Pharmacology.Altered pharmacokinetics and pharmacodynamics of the CYP3A substrate, midazolam, during hepatic inflammation induced by bacterial endotoxins. British Journal of Pharmacology. 2012; 166(7):2167-87.2012-08-01T00:00:002012Altered pharmacokinetics and pharmacodynamics of the CYP3A substrate, midazolam, during hepatic inflammation induced by bacterial endotoxins. British Journal of Pharmacology21303924Ghose R, Guo T, Vallejo JG, Gandhi ADrug metabolism and disposition: the biological fate of chemicalsDifferential role of Toll-interleukin 1 receptor domain-containing adaptor protein in Toll-like receptor 2-mediated regulation of gene expression of hepatic cytokines and drug-metabolizing enzymes. Drug Metab Dispos. 2011 May; 39(5):874-81.Drug Metab Dispos2011-02-08T00:00:002011Differential role of Toll-interleukin 1 receptor domain-containing adaptor protein in Toll-like receptor 2-mediated regulation of gene expression of hepatic cytokines and drug-metabolizing enzymes.21620874Ghose R, Omoluabi O, Gandhi A, Shah P, Strohacker K, Carpenter KC, McFarlin B, Guo TLife sciencesRole of high-fat diet in regulation of gene expression of drug metabolizing enzymes and transporters. Life Sci. 2011 Jul 04; 89(1-2):57-64.Life Sci2011-05-18T00:00:002011Role of high-fat diet in regulation of gene expression of drug metabolizing enzymes and transporters.Authorship 840671428242239Mallick P, Basu S, Moorthy B, Ghose RToxicology in vitro : an international journal published in association with BIBRARole of Toll-like receptor 4 in drug-drug interaction between paclitaxel and irinotecan in vitro. Toxicol In Vitro. 2017 Jun; 41:75-82.Toxicol In Vitro2017-02-27T00:00:002017Role of Toll-like receptor 4 in drug-drug interaction between paclitaxel and irinotecan in vitro.Authorship 872458428537216Mallick P, Taneja G, Moorthy B, Ghose RExpert opinion on drug metabolism & toxicologyRegulation of drug-metabolizing enzymes in infectious and inflammatory disease: implications for biologics-small molecule drug interactions. Expert Opin Drug Metab Toxicol. 2017 Jun; 13(6):605-616.Expert Opin Drug Metab Toxicol2017-02-22T00:00:002017Regulation of drug-metabolizing enzymes in infectious and inflammatory disease: implications for biologics-small molecule drug interactions.Authorship 876584628766962Myers AL, Kawedia JD, Champlin RE, Kramer MA, Nieto Y, Ghose R, Andersson BSExpert opinion on drug metabolism & toxicologyClarifying busulfan metabolism and drug interactions to support new therapeutic drug monitoring strategies: a comprehensive review. Expert Opin Drug Metab Toxicol. 2017 Sep; 13(9):901-923.Expert Opin Drug Metab Toxicol2017-08-17T00:00:002017Clarifying busulfan metabolism and drug interactions to support new therapeutic drug monitoring strategies: a comprehensive review.Authorship 880661529440179Taneja G, Chu C, Maturu P, Moorthy B, Ghose RDrug metabolism and disposition: the biological fate of chemicalsRole of c-Jun-N-Terminal Kinase in Pregnane X Receptor-Mediated Induction of Human Cytochrome P4503A4 In Vitro. Drug Metab Dispos. 2018 04; 46(4):397-404.Drug Metab Dispos2018-02-12T00:00:002018Role of c-Jun-N-Terminal Kinase in Pregnane X Receptor-Mediated Induction of Human Cytochrome P4503A4 In Vitro.true1ProfessorProfessortrue1Associate ProfessorAssociate Professortrue1ProfessorProfessortrue1ProfessorProfessorD014453Chemicals & Drugs581040.925187GlucuronosyltransferaseD008099Anatomy92029630.482513LiverD002166Chemicals & Drugs2065150.798643CamptothecinD000972Chemicals & Drugs3458520.696165Antineoplastic Agents, PhytogenicAuthorship 9254437Authorship 936240829913120Mallick P, Shah P, Ittmann MM, Trivedi M, Hu M, Gao S, Ghose RChemico-biological interactionsImpact of diet on irinotecan toxicity in mice. Chem Biol Interact. 2018 Aug 01; 291:87-94.Chem Biol Interact2018-06-18T00:00:002018Impact of diet on irinotecan toxicity in mice.30607980Paranjpe R, Basatneh D, Tao G, De Angelis C, Noormohammed S, Ekinci E, Abughosh S, Ghose R, Trivedi MVThe Annals of pharmacotherapyNeratinib in HER2-Positive Breast Cancer Patients. Ann Pharmacother. 2019 06; 53(6):612-620.Ann Pharmacother2019-01-04T00:00:002019Neratinib in HER2-Positive Breast Cancer Patients.D051544Chemicals & Drugs54840.934161Cytochrome P-450 CYP3A2012-07-31NIHGHOSE, ROMI2006-08-22Hepatic drug metabolism in inflammationK01DK0760572019-02-28NIHGHOSE, ROMI2014-03-15Novel in vivo regulatory mechanisms of human CYP3A4R21DA035751Principal InvestigatorPrincipal InvestigatorPharmacological & Pharmaceutical SciencesDepartment of PediatricsDepartment of Molecular & Cellular BiologyMolecular & Cellular BiologyPediatrics-Infectious DiseasesPediatrics-NewbornBaylor College of MedicineUniversity of Houston College of PharmacyCRISTIANCOARFACRISTIAN COARFA0.000000000000000.000000000000001149COARFA, CRISTIANAssociate ProfessorJESUSVALLEJOJESUS VALLEJO0.000000000000000.000000000000003115VALLEJO, JESUSProfessorBHAGAVATULAMOORTHYBHAGAVATULA MOORTHY29.70508570000000-95.401808700000003327MOORTHY, BHAGAVATULAProfessorKIMBERLYBIRTCHERKIMBERLY K. BIRTCHER 29.70508570000000-95.401808700000004592BIRTCHER, KIMBERLYClinical ProfessorMINGHUMING HU29.70508570000000-95.401808700000004600HU, MINGProfessor3.023120.00870752185research areas1.66010.039522313coauthor of24.44477.1689260similar to1134selected publicationsJULIANNAFERNANDEZJULIANNA M. FERNANDEZ29.70508570000000-95.401808700000004609FERNANDEZ, JULIANNAClinical Associate ProfessorBERTO'MALLEYBERT O'MALLEY0.000000000000000.000000000000002464O'MALLEY, BERTDistinguished Service ProfessorEKEREESSIENEKERE JAMES ESSIEN 29.70508570000000-95.401808700000004598ESSIEN, EKEREProfessorDIANACHOWDIANA S-L. CHOW29.70508570000000-95.401808700000004619CHOW, DIANAProfessorAuthorship 946384631040347Taneja G, Maity S, Jiang W, Moorthy B, Coarfa C, Ghose RScientific reportsTranscriptomic profiling identifies novel mechanisms of transcriptional regulation of the cytochrome P450 (Cyp)3a11 gene. Sci Rep. 2019 04 30; 9(1):6663.Sci Rep2019-04-30T00:00:002019Transcriptomic profiling identifies novel mechanisms of transcriptional regulation of the cytochrome P450 (Cyp)3a11 gene.Authorship 955352631509102Sun R, Basu S, Zeng M, Sunsong R, Li L, Ghose R, Wang W, Liu Z, Hu M, Gao SCurrent cancer drug targetsXiao-Chai-Hu-Tang (XCHT) Intervening Irinotecan's Disposition: The Potential of XCHT in Alleviating Irinotecan-Induced Diarrhea. Curr Cancer Drug Targets. 2019; 19(7):551-560.Curr Cancer Drug Targets2019-01-01T00:00:002019Xiao-Chai-Hu-Tang (XCHT) Intervening Irinotecan's Disposition: The Potential of XCHT in Alleviating Irinotecan-Induced Diarrhea.true1Clinical ProfessorClinical Professortrue1Clinical Associate ProfessorClinical Associate ProfessorPharmacy Practice and Translational Researchtrue1ProfessorProfessortrue1ProfessorProfessortrue1Distinguished Service ProfessorDistinguished Service ProfessorAuthorship 974609431870839Chityala PK, Wu L, Chow DS, Ghose RChemico-biological interactionsEffects of inflammation on irinotecan pharmacokinetics and development of a best-fit PK model. Chem Biol Interact. 2020 Jan 25; 316:108933.Chem Biol Interact2019-12-20T00:00:002019Effects of inflammation on irinotecan pharmacokinetics and development of a best-fit PK model.Authorship 989169832387182Sun R, Zhu L, Li L, Song W, Gong X, Qi X, Wang Y, Ghose R, Gao S, Hu M, Liu ZToxicology and applied pharmacologyIrinotecan-mediated diarrhea is mainly correlated with intestinal exposure to SN-38: Critical role of gut Ugt. Toxicol Appl Pharmacol. 2020 07 01; 398:115032.Toxicol Appl Pharmacol2020-05-05T00:00:002020Irinotecan-mediated diarrhea is mainly correlated with intestinal exposure to SN-38: Critical role of gut Ugt.Authorship 997966732841068Tao G, Huang J, Moorthy B, Wang C, Hu M, Gao S, Ghose RExpert opinion on drug metabolism & toxicologyPotential role of drug metabolizing enzymes in chemotherapy-induced gastrointestinal toxicity and hepatotoxicity. Expert Opin Drug Metab Toxicol. 2020 Nov; 16(11):1109-1124.Expert Opin Drug Metab Toxicol2020-09-02T00:00:002020Potential role of drug metabolizing enzymes in chemotherapy-induced gastrointestinal toxicity and hepatotoxicity.Authorship 1012790233666138Jonsson-Schmunk K, Ghose R, Croyle MAExpert review of vaccinesImmunization and Drug Metabolizing Enzymes: Focus on Hepatic Cytochrome P450 3A. Expert Rev Vaccines. 2021 05; 20(5):623-634.Expert Rev Vaccines2021-03-18T00:00:002021Immunization and Drug Metabolizing Enzymes: Focus on Hepatic Cytochrome P450 3A.true1Associate ProfessorAssociate ProfessorAuthorship 141Authorship 1041350335237423Tao G, Dagher F, Ghose RToxicology researchNeratinib causes non-recoverable gut injury and reduces intestinal cytochrome P450 3A enzyme in mice. Toxicol Res (Camb). 2022 Feb; 11(1):184-194.Toxicol Res (Camb)2022-01-18T00:00:002022Neratinib causes non-recoverable gut injury and reduces intestinal cytochrome P450 3A enzyme in mice.Authorship 1044008535430260Tao G, Chityala PK, Li L, Lin Z, Ghose RChemico-biological interactionsDevelopment of a physiologically based pharmacokinetic model to predict irinotecan disposition during inflammation. Chem Biol Interact. 2022 Jun 01; 360:109946.Chem Biol Interact2022-04-14T00:00:002022Development of a physiologically based pharmacokinetic model to predict irinotecan disposition during inflammation.Authorship 137371424194512Shah P, Guo T, Moore DD, Ghose RDrug metabolism and disposition: the biological fate of chemicalsRole of constitutive androstane receptor in Toll-like receptor-mediated regulation of gene expression of hepatic drug-metabolizing enzymes and transporters. Drug Metab Dispos. 2014 Jan; 42(1):172-81.Drug Metab Dispos2013-11-05T00:00:002013Role of constitutive androstane receptor in Toll-like receptor-mediated regulation of gene expression of hepatic drug-metabolizing enzymes and transporters.Authorship 1048733635728726Tao G, Dagher F, Li L, Singh R, Hu M, Ghose RFood and chemical toxicology : an international journal published for the British Industrial Biological Research AssociationIrinotecan decreases intestinal UDP-glucuronosyltransferase (UGT) 1A1 via TLR4/MyD88 pathway prior to the onset of diarrhea. Food Chem Toxicol. 2022 Aug; 166:113246.Food Chem Toxicol2022-06-18T00:00:002022Irinotecan decreases intestinal UDP-glucuronosyltransferase (UGT) 1A1 via TLR4/MyD88 pathway prior to the onset of diarrhea.Authorship 160Authorship 1057201636495622Tao G, Dagher F, Li L, Singh R, Hu M, Ghose RFood and chemical toxicology : an international journal published for the British Industrial Biological Research AssociationCorrigendum to "Irinotecan decreases intestinal UDP-glucuronosyltransferase (UGT) 1A1 via TLR4/MyD88 pathway prior to the onset of diarrhea" [Food Chem. Toxicol. 166 (2022) 113246]. Food Chem Toxicol. 2022 Dec 07; 171:113547.Food Chem Toxicol2022-12-07T00:00:002022Corrigendum to "Irinotecan decreases intestinal UDP-glucuronosyltransferase (UGT) 1A1 via TLR4/MyD88 pathway prior to the onset of diarrhea" [Food Chem. Toxicol. 166 (2022) 113246].Authorship 133793true1ProfessorProfessortrue1Assistant ProfessorAssistant Professortrue1ProfessorProfessortrue1ProfessorProfessorAuthorship 317413Authorship 684061Authorship 767223