LISABOUCHIER-HAYESLISA BOUCHIER-HAYES0.000000000000000.000000000000003984BOUCHIER-HAYES, LISAAssociate Professorplugins:TwitterTwitterprns:coAuthorOfcoauthor ofprns:endDateend dateFaculty Rankprns:fullNamefull nameprns:grantAwardedBygrant awarded byprns:hasAuthorListauthor listprns:hasFacultyRankhas faculty rankprns:hasNetworkhas networkprns:hasPublicationVenuepublished inprns:informationResourceReferenceinformation resource referenceprns:isPrimaryPositionis primary positionprns:latitudelatitudeprns:longitudelongitudeprns:mainImagephotoprns:maxWeightmaximum weightprns:medlineTAjournal title abbreviationprns:meshDescriptorUIMeSH DescriptorUIprns:meshSemanticGroupNameMeSH semantic group nameprns:minWeightminimum weightprns:numberOfAuthorsnumber of authorsprns:numberOfConnectionsnumber of connectionsprns:numberOfPublicationsnumber of publicationsprns:personIdPerson IDprns:personInPrimaryPositionperson in primary positionprns:physicalNeighborOfphysical neighborprns:pluginSearchableDataProfilesRNS Plugin Searchable Dataprns:positionInDepartmentposition in departmentprns:positionInDivisionposition in divisionprns:predicateNodepredicate nodeprns:principalInvestigatorNameprincipal investigator nameprns:publicationDatepublication dateprns:similarTosimilar toprns:sortOrdersort orderprns:startDatestart dateprns:uniquenessWeightuniqueness weightprns:yearyearAcademic ArticleArticleDocumentbibo:pmidPubMed IdentifierAddressvivo:address1address line 1vivo:addressCitycityvivo:addressPostalCodepostal codevivo:addressStatestate or provinceAgreementvivo:authorInAuthorshipselected publicationsvivo:authorRankauthor rank in publicationAuthorshipDepartmentDivisionGrantvivo:hasResearchArearesearch areasvivo:hasResearcherRoleresearch activitiesvivo:hrJobTitleHR job titleInformation Resourcevivo:linkedAuthorlinked authorvivo:linkedInformationResourcelinked information resourcevivo:mailingAddressmailing addressvivo:personInPositionpositionsPositionvivo:positionInOrganizationposition in organizationvivo:preferredTitlepreferred titleResearcher Rolevivo:researcherRoleOfresearcher role ofRolevivo:roleContributesTocontributes tovivo:sponsorAwardIdsponsor award idrdf:predicatepredicaterdf:typetyperdfs:labellabelConceptAgentfoaf:firstNamefirst namefoaf:lastNamelast nameOrganizationPerson25323693Ando M, Hoyos V, Yagyu S, Tao W, Ramos CA, Dotti G, Brenner MK, Bouchier-Hayes LCancer gene therapyBortezomib sensitizes non-small cell lung cancer to mesenchymal stromal cell-delivered inducible caspase-9-mediated cytotoxicity. Cancer Gene Ther. 2014 Nov; 21(11):472-482.Cancer Gene Ther2014-10-17T00:00:002014Bortezomib sensitizes non-small cell lung cancer to mesenchymal stromal cell-delivered inducible caspase-9-mediated cytotoxicity.25561623Parsons MJ, Bouchier-Hayes LCold Spring Harbor protocolsMeasuring initiator caspase activation by bimolecular fluorescence complementation. Cold Spring Harb Protoc. 2015 Jan 05; 2015(1):pdb.prot082552.Cold Spring Harb Protoc2015-01-05T00:00:002015Measuring initiator caspase activation by bimolecular fluorescence complementation.25561624Rehm M, Parsons MJ, Bouchier-Hayes LCold Spring Harbor protocolsMeasuring caspase activity by F?rster resonance energy transfer. Cold Spring Harb Protoc. 2015 Jan 05; 2015(1):pdb.prot082560.Cold Spring Harb Protoc2015-01-05T00:00:002015Measuring caspase activity by F?rster resonance energy transfer.25561626Parsons MJ, Rehm M, Bouchier-Hayes LCold Spring Harbor protocolsImaging-based methods for assessing caspase activity in single cells. Cold Spring Harb Protoc. 2015 Jan 05; 2015(1):pdb.top070342.Cold Spring Harb Protoc2015-01-05T00:00:002015Imaging-based methods for assessing caspase activity in single cells.Authorship 812372Authorship 893584Authorship 993911Authorship 1103332Authorship 1114572Authorship 190981Authorship 1617881325702873Ichim G, Lopez J, Ahmed SU, Muthalagu N, Giampazolias E, Delgado ME, Haller M, Riley JS, Mason SM, Athineos D, Parsons MJ, van de Kooij B, Bouchier-Hayes L, Chalmers AJ, Rooswinkel RW, Oberst A, Blyth K, Rehm M, Murphy DJ, Tait SWGMolecular cellLimited mitochondrial permeabilization causes DNA damage and genomic instability in the absence of cell death. Mol Cell. 2015 Mar 05; 57(5):860-872.Mol Cell2015-02-19T00:00:002015Limited mitochondrial permeabilization causes DNA damage and genomic instability in the absence of cell death.LeukemiaMolecular & Cellular OncologySystems BiologyMD AndersonMIEN-CHIEHUNGMIEN-CHIE HUNG8427HUNG, MIEN-CHIEProfessorMICHAELANDREEFFMICHAEL ANDREEFF8437ANDREEFF, MICHAELProfessorGORDON BMILLSGORDON B MILLS8620MILLS, GORDON BProfessorMARINAKONOPLEVAMARINA KONOPLEVA8702KONOPLEVA, MARINAProfessorAuthorship 450751Authorship 939561Authorship 3047287Authorship 305539726084970Hoyos V, Del Bufalo F, Yagyu S, Ando M, Dotti G, Suzuki M, Bouchier-Hayes L, Alemany R, Brenner MKMolecular therapy : the journal of the American Society of Gene TherapyMesenchymal Stromal Cells for Linked Delivery of Oncolytic and Apoptotic Adenoviruses to Non-small-cell Lung Cancers. Mol Ther. 2015 Sep; 23(9):1497-506.Mol Ther2015-06-18T00:00:002015Mesenchymal Stromal Cells for Linked Delivery of Oncolytic and Apoptotic Adenoviruses to Non-small-cell Lung Cancers.26158519Sanders MG, Parsons MJ, Howard AG, Liu J, Fassio SR, Martinez JA, Bouchier-Hayes LCell death & diseaseSingle-cell imaging of inflammatory caspase dimerization reveals differential recruitment to inflammasomes. Cell Death Dis. 2015 Jul 09; 6:e1813.Cell Death Dis2015-07-09T00:00:002015Single-cell imaging of inflammatory caspase dimerization reveals differential recruitment to inflammasomes.12101092Bouchier-Hayes L, Martin SJEMBO reportsCARD games in apoptosis and immunity. EMBO Rep. 2002 Jul; 3(7):616-21.EMBO Rep2002-07-01T00:00:002002CARD games in apoptosis and immunity.11121194Mynett-Johnson L, Kealey C, Claffey E, Curtis D, Bouchier-Hayes L, Powell C, McKeon PAmerican journal of medical geneticsMultimarkerhaplotypes within the serotonin transporter gene suggest evidence of an association with bipolar disorder. Am J Med Genet. 2000 Dec 04; 96(6):845-9.Am J Med Genet2000-12-04T00:00:002000Multimarkerhaplotypes within the serotonin transporter gene suggest evidence of an association with bipolar disorder.15110175Bouchier-Hayes L, Martin SJVitamins and hormonesCARDINAL roles in apoptosis and NFkappaB activation. Vitam Horm. 2004; 67:133-47.Vitam Horm2004-01-01T00:00:002004CARDINAL roles in apoptosis and NFkappaB activation.Authorship 3161393Authorship 316140527108430Parsons MJ, Fassio SR, Bouchier-Hayes LMethods in molecular biology (Clifton, N.J.)Detection of Initiator Caspase Induced Proximity in Single Cells by Caspase Bimolecular Fluorescence Complementation. Methods Mol Biol. 2016; 1419:41-56.Methods Mol Biol2016-01-01T00:00:002016Detection of Initiator Caspase Induced Proximity in Single Cells by Caspase Bimolecular Fluorescence Complementation.26804704Manton CA, Johnson B, Singh M, Bailey CP, Bouchier-Hayes L, Chandra JScientific reportsInduction of cell death by the novel proteasome inhibitor marizomib in glioblastoma in vitro and in vivo. Sci Rep. 2016 Jan 25; 6:18953.Sci Rep2016-01-25T00:00:002016Induction of cell death by the novel proteasome inhibitor marizomib in glioblastoma in vitro and in vivo.10760520Keogh SA, Walczak H, Bouchier-Hayes L, Martin SJFEBS lettersFailure of Bcl-2 to block cytochrome c redistribution during TRAIL-induced apoptosis. FEBS Lett. 2000 Apr 07; 471(1):93-8.FEBS Lett2000-04-07T00:00:002000Failure of Bcl-2 to block cytochrome c redistribution during TRAIL-induced apoptosis.74Professor10Assistant Professor14Associate Professor47Distinguished Service ProfessorKAPILBHALLAKAPIL BHALLA11899BHALLA, KAPILProfessor12485664Glaser M, Collingridge DR, Aboagye EO, Bouchier-Hayes L, Hutchinson OC, Martin SJ, Price P, Brady F, Luthra SKApplied radiation and isotopes : including data, instrumentation and methods for use in agriculture, industry and medicineIodine-124 labelled annexin-V as a potential radiotracer to study apoptosis using positron emission tomography. Appl Radiat Isot. 2003 Jan; 58(1):55-62.Appl Radiat Isot2003-01-01T00:00:002003Iodine-124 labelled annexin-V as a potential radiotracer to study apoptosis using positron emission tomography.11551959Bouchier-Hayes L, Conroy H, Egan H, Adrain C, Creagh EM, MacFarlane M, Martin SJThe Journal of biological chemistryCARDINAL, a novel caspase recruitment domain protein, is an inhibitor of multiple NF-kappa B activation pathways. J Biol Chem. 2001 Nov 23; 276(47):44069-77.J Biol Chem2001-09-10T00:00:002001CARDINAL, a novel caspase recruitment domain protein, is an inhibitor of multiple NF-kappa B activation pathways.14520468Collingridge DR, Glaser M, Osman S, Barthel H, Hutchinson OC, Luthra SK, Brady F, Bouchier-Hayes L, Martin SJ, Workman P, Price P, Aboagye EOBritish journal of cancerIn vitro selectivity, in vivo biodistribution and tumour uptake of annexin V radiolabelled with a positron emitting radioisotope. Br J Cancer. 2003 Oct 06; 89(7):1327-33.Br J Cancer2003-10-06T00:00:002003In vitro selectivity, in vivo biodistribution and tumour uptake of annexin V radiolabelled with a positron emitting radioisotope.1102 BATESHouston, 77030TX53Graduate Student20016258Bouchier-Hayes L, Green DRCell cycle (Georgetown, Tex.)Real time with caspase-2. Cell Cycle. 2010 Jan 01; 9(1):12-3.Cell Cycle2010-01-01T00:00:002010Real time with caspase-2.20150914Bouchier-Hayes L, McBride S, van Geelen CM, Nance S, Lewis LK, Pinkoski MJ, Beere HMCell death and differentiationFas ligand gene expression is directly regulated by stress-inducible heat shock transcription factor-1. Cell Death Differ. 2010 Jun; 17(6):1034-46.Cell Death Differ2010-02-12T00:00:002010Fas ligand gene expression is directly regulated by stress-inducible heat shock transcription factor-1.16151013Chipuk JE, Bouchier-Hayes L, Kuwana T, Newmeyer DD, Green DRScience (New York, N.Y.)PUMA couples the nuclear and cytoplasmic proapoptotic function of p53. Science. 2005 Sep 09; 309(5741):1732-5.Science2005-09-09T00:00:002005PUMA couples the nuclear and cytoplasmic proapoptotic function of p53.16200197Bouchier-Hayes L, Lartigue L, Newmeyer DDThe Journal of clinical investigationMitochondria: pharmacological manipulation of cell death. J Clin Invest. 2005 Oct; 115(10):2640-7.J Clin Invest2005-10-01T00:00:002005Mitochondria: pharmacological manipulation of cell death.16710362Chipuk JE, Bouchier-Hayes L, Green DRCell death and differentiationMitochondrial outer membrane permeabilization during apoptosis: the innocent bystander scenario. Cell Death Differ. 2006 Aug; 13(8):1396-402.Cell Death Differ2006-05-19T00:00:002006Mitochondrial outer membrane permeabilization during apoptosis: the innocent bystander scenario.17540177Colell A, Ricci JE, Tait S, Milasta S, Maurer U, Bouchier-Hayes L, Fitzgerald P, Guio-Carrion A, Waterhouse NJ, Li CW, Mari B, Barbry P, Newmeyer DD, Beere HM, Green DRCellGAPDH and autophagy preserve survival after apoptotic cytochrome c release in the absence of caspase activation. Cell. 2007 Jun 01; 129(5):983-97.Cell2007-06-01T00:00:002007GAPDH and autophagy preserve survival after apoptotic cytochrome c release in the absence of caspase activation.18314052Bouchier-Hayes L, Mu?oz-Pinedo C, Connell S, Green DRMethods (San Diego, Calif.)Measuring apoptosis at the single cell level. Methods. 2008 Mar; 44(3):222-8.Methods2008-03-01T00:00:002008Measuring apoptosis at the single cell level.19609747Tait SW, Bouchier-Hayes L, Oberst A, Connell S, Green DRMethods in molecular biology (Clifton, N.J.)Live to dead cell imaging. Methods Mol Biol. 2009; 559:33-48.Methods Mol Biol2009-01-01T00:00:002009Live to dead cell imaging.Authorship 654276627991927Dawar S, Lim Y, Puccini J, White M, Thomas P, Bouchier-Hayes L, Green DR, Dorstyn L, Kumar SOncogeneCaspase-2-mediated cell death is required for deleting aneuploid cells. Oncogene. 2017 05 11; 36(19):2704-2714.Oncogene2016-12-19T00:00:002016Caspase-2-mediated cell death is required for deleting aneuploid cells.19782032Bouchier-Hayes L, Oberst A, McStay GP, Connell S, Tait SW, Dillon CP, Flanagan JM, Beere HM, Green DRMolecular cellCharacterization of cytoplasmic caspase-2 activation by induced proximity. Mol Cell. 2009 Sep 24; 35(6):830-40.Mol Cell2009-09-24T00:00:002009Characterization of cytoplasmic caspase-2 activation by induced proximity.20158568Bouchier-Hayes LJournal of cellular and molecular medicineThe role of caspase-2 in stress-induced apoptosis. J Cell Mol Med. 2010 Jun; 14(6A):1212-24.J Cell Mol Med2010-02-16T00:00:002010The role of caspase-2 in stress-induced apoptosis.Authorship 100866620493813Tait SW, Parsons MJ, Llambi F, Bouchier-Hayes L, Connell S, Mu?oz-Pinedo C, Green DRDevelopmental cellResistance to caspase-independent cell death requires persistence of intact mitochondria. Dev Cell. 2010 May 18; 18(5):802-13.Dev Cell2010-05-18T00:00:002010Resistance to caspase-independent cell death requires persistence of intact mitochondria.22036586Llambi F, Moldoveanu T, Tait SW, Bouchier-Hayes L, Temirov J, McCormick LL, Dillon CP, Green DRMolecular cellA unified model of mammalian BCL-2 protein family interactions at the mitochondria. Mol Cell. 2011 Nov 18; 44(4):517-31.Mol Cell2011-10-27T00:00:002011A unified model of mammalian BCL-2 protein family interactions at the mitochondria.22854598Ando K, Kernan JL, Liu PH, Sanda T, Logette E, Tschopp J, Look AT, Wang J, Bouchier-Hayes L, Sidi SMolecular cellPIDD death-domain phosphorylation by ATM controls prodeath versus prosurvival PIDDosome signaling. Mol Cell. 2012 Sep 14; 47(5):681-93.Mol Cell2012-07-30T00:00:002012PIDD death-domain phosphorylation by ATM controls prodeath versus prosurvival PIDDosome signaling.Authorship 8691871028432080Ando K, Parsons MJ, Shah RB, Charendoff CI, Paris SL, Liu PH, Fassio SR, Rohrman BA, Thompson R, Oberst A, Sidi S, Bouchier-Hayes LThe Journal of cell biologyNPM1 directs PIDDosome-dependent caspase-2 activation in the nucleolus. J Cell Biol. 2017 06 05; 216(6):1795-1810.J Cell Biol2017-04-21T00:00:002017NPM1 directs PIDDosome-dependent caspase-2 activation in the nucleolus.Authorship 876150128749201Bouchier-Hayes L, Sidi SCell cycle (Georgetown, Tex.)The nucleolus: A new home for the PIDDosome. Cell Cycle. 2017; 16(17):1562-1563.Cell Cycle2017-07-27T00:00:002017The nucleolus: A new home for the PIDDosome.14963330Chipuk JE, Kuwana T, Bouchier-Hayes L, Droin NM, Newmeyer DD, Schuler M, Green DRScience (New York, N.Y.)Direct activation of Bax by p53 mediates mitochondrial membrane permeabilization and apoptosis. Science. 2004 Feb 13; 303(5660):1010-4.Science2004-02-13T00:00:002004Direct activation of Bax by p53 mediates mitochondrial membrane permeabilization and apoptosis.15721256Kuwana T, Bouchier-Hayes L, Chipuk JE, Bonzon C, Sullivan BA, Green DR, Newmeyer DDMolecular cellBH3 domains of BH3-only proteins differentially regulate Bax-mediated mitochondrial membrane permeabilization both directly and indirectly. Mol Cell. 2005 Feb 18; 17(4):525-35.Mol Cell2005-02-18T00:00:002005BH3 domains of BH3-only proteins differentially regulate Bax-mediated mitochondrial membrane permeabilization both directly and indirectly.16495337Bonzon C, Bouchier-Hayes L, Pagliari LJ, Green DR, Newmeyer DDMolecular biology of the cellCaspase-2-induced apoptosis requires bid cleavage: a physiological role for bid in heat shock-induced death. Mol Biol Cell. 2006 May; 17(5):2150-7.Mol Biol Cell2006-02-22T00:00:002006Caspase-2-induced apoptosis requires bid cleavage: a physiological role for bid in heat shock-induced death.22075987Bouchier-Hayes L, Green DRCell death and differentiationCaspase-2: the orphan caspase. Cell Death Differ. 2012 Jan; 19(1):51-7.Cell Death Differ2011-11-11T00:00:002011Caspase-2: the orphan caspase.Authorship 8815081Authorship 884005229057309Sidi S, Bouchier-Hayes LMolecular & cellular oncologyDirect pro-apoptotic role for NPM1 as a regulator of PIDDosome formation. Mol Cell Oncol. 2017; 4(5):e1348325.Mol Cell Oncol2017-07-05T00:00:002017Direct pro-apoptotic role for NPM1 as a regulator of PIDDosome formation.29553529Charendoff CI, Bouchier-Hayes LJournal of visualized experiments : JoVELighting Up the Pathways to Caspase Activation Using Bimolecular Fluorescence Complementation. J Vis Exp. 2018 03 05; (133).J Vis Exp2018-03-05T00:00:002018Lighting Up the Pathways to Caspase Activation Using Bimolecular Fluorescence Complementation.VALENTINAHOYOSVALENTINA HOYOS13961HOYOS, VALENTINAAssistant Professortrue1Assistant ProfessorAssistant Professortrue1ProfessorProfessortrue1Associate ProfessorAssociate ProfessorD020169Chemicals & Drugs2826620.79999CaspasesD017209Physiology136375940.352863ApoptosisD053143Chemicals & Drugs21390.976528Caspase 2D008164Chemicals & Drugs1912890.908472Luminescent ProteinsAlexandraBrown-SuedelAlexandra Nicole Brown-Suedel14438Brown-Suedel, AlexandraGraduate StudentAuthorship 1087651Department of MedicineDepartment of PediatricsDepartment of Molecular & Cellular BiologyMedicine-Hematology & OncologyMolecular & Cellular BiologyPediatrics-HematologyPediatrics-Hematology & OncologyPediatrics-OncologyBaylor College of MedicineNINORAINUSSONINO RAINUSSO0.000000000000000.000000000000001089RAINUSSO, NINOAssociate ProfessorKENNETHMCCLAINKENNETH MCCLAIN0.000000000000000.000000000000003155MCCLAIN, KENNETHProfessorMALCOLMBRENNERMALCOLM BRENNER0.000000000000000.000000000000003564BRENNER, MALCOLMDistinguished Service ProfessorJONATHANFLANAGANJONATHAN FLANAGAN0.000000000000000.000000000000003971FLANAGAN, JONATHANAssistant Professor5.676210.00148541287research areas2.430490.031954713coauthor of50.17118.5540160similar to1153selected publicationsMICHELEREDELLMICHELE REDELL0.000000000000000.000000000000002094REDELL, MICHELEAssociate ProfessorPrincipal Investigator2023-04-30NIHBOUCHIER-HAYES, LISA2018-05-01Non-apoptotic functions of caspase-2 in cell division and genomic stabilityR01GM121389Authorship 1262395D058847Chemicals & Drugs781610.838646Inflammasomes23645210Parsons MJ, McCormick L, Janke L, Howard A, Bouchier-Hayes L, Green DRCell death and differentiationGenetic deletion of caspase-2 accelerates MMTV/c-neu-driven mammary carcinogenesis in mice. Cell Death Differ. 2013 Sep; 20(9):1174-82.Cell Death Differ2013-05-03T00:00:002013Genetic deletion of caspase-2 accelerates MMTV/c-neu-driven mammary carcinogenesis in mice.Authorship 947074231090171Bol?var BE, Vogel TP, Bouchier-Hayes LThe FEBS journalInflammatory caspase regulation: maintaining balance between inflammation and cell death in health and disease. FEBS J. 2019 07; 286(14):2628-2644.FEBS J2019-05-27T00:00:002019Inflammatory caspase regulation: maintaining balance between inflammation and cell death in health and disease.Authorship 1107101true1Distinguished Service ProfessorDistinguished Service Professortrue1Assistant ProfessorAssistant Professortrue1Graduate StudentGraduate Studenttrue1Graduate StudentGraduate StudentCancer & Cell BiologyIntegrative Molecular and Biomedical SciencesKarlaLopezKarla Elena Lopez15003Lopez, KarlaGraduate StudentSARAHWHITTLESARAH WHITTLE0.000000000000000.000000000000006432WHITTLE, SARAHAssociate ProfessorRAYNEROUCERAYNE ROUCE0.000000000000000.000000000000005730ROUCE, RAYNEAssociate ProfessorAuthorship 978385232087180Boice A, Bouchier-Hayes LBiochimica et biophysica acta. Molecular cell researchTargeting apoptotic caspases in cancer. Biochim Biophys Acta Mol Cell Res. 2020 06; 1867(6):118688.Biochim Biophys Acta Mol Cell Res2020-02-19T00:00:002020Targeting apoptotic caspases in cancer.Authorship 1152218Authorship 1008666233425918Brown-Suedel AN, Bouchier-Hayes LFrontiers in cell and developmental biologyCaspase-2 Substrates: To Apoptosis, Cell Cycle Control, and Beyond. Front Cell Dev Biol. 2020; 8:610022.Front Cell Dev Biol2020-12-23T00:00:002020Caspase-2 Substrates: To Apoptosis, Cell Cycle Control, and Beyond.2023-06-30NIHBOUCHIER-HAYES, LISA2021-01-15Mechanisms of caspase-2 activation by nucleophosmin in AML cell death and survivalR21CA256606Principal InvestigatorAuthorship 1014126733741688Bol?var BE, Brown-Suedel AN, Rohrman BA, Charendoff CI, Yazdani V, Belcher JD, Vercellotti GM, Flanagan JM, Bouchier-Hayes LJournal of immunology (Baltimore, Md. : 1950)Noncanonical Roles of Caspase-4 and Caspase-5 in Heme-Driven IL-1? Release and Cell Death. J Immunol. 2021 04 15; 206(8):1878-1889.J Immunol2021-03-19T00:00:002021Noncanonical Roles of Caspase-4 and Caspase-5 in Heme-Driven IL-1? Release and Cell Death.true1Associate ProfessorAssociate ProfessorTwitter Tweets Harvard Tweets34718349Boice AG, Lopez KE, Pandita RK, Parsons MJ, Charendoff CI, Charaka V, Carisey AF, Pandita TK, Bouchier-Hayes LOncogeneCaspase-2 regulates S-phase cell cycle events to protect from DNA damage accumulation independent of apoptosis. Oncogene. 2022 01; 41(2):204-219.Oncogene2021-10-30T00:00:002021Caspase-2 regulates S-phase cell cycle events to protect from DNA damage accumulation independent of apoptosis.Authorship 10334609true1Associate ProfessorAssociate Professor2Associate ProfessorAssociate ProfessorAuthorship 1040095235043564Sakthivel D, Bol?var BE, Bouchier-Hayes LThe FEBS journalCellular autophagy, an unbidden effect of caspase inhibition by zVAD-fmk. FEBS J. 2022 06; 289(11):3097-3100.FEBS J2022-01-18T00:00:002022Cellular autophagy, an unbidden effect of caspase inhibition by zVAD-fmk.Authorship 1044453135467667Bol?var BE, Bouchier-Hayes LJournal of visualized experiments : JoVEVisualization of Inflammatory Caspases Induced Proximity in Human Monocyte-Derived Macrophages. J Vis Exp. 2022 04 06; (182).J Vis Exp2022-04-06T00:00:002022Visualization of Inflammatory Caspases Induced Proximity in Human Monocyte-Derived Macrophages.Authorship 1048044935705736Boice AG, Lopez KE, Pandita RK, Parsons MJ, Charendoff CI, Charaka V, Carisey AF, Pandita TK, Bouchier-Hayes LOncogeneCorrection: Caspase-2 regulates S-phase cell cycle events to protect from DNA damage accumulation independent of apoptosis. Oncogene. 2022 Jul; 41(29):3732-3734.Oncogene2022-07-01T00:00:002022Correction: Caspase-2 regulates S-phase cell cycle events to protect from DNA damage accumulation independent of apoptosis.Authorship 1048812235741016Lopez KE, Bouchier-Hayes LCellsLethal and Non-Lethal Functions of Caspases in the DNA Damage Response. Cells. 2022 06 10; 11(12).Cells2022-06-10T00:00:002022Lethal and Non-Lethal Functions of Caspases in the DNA Damage Response.Authorship 155211true1Associate ProfessorAssociate Professor36041706Salgar S, Bol?var BE, Flanagan JM, Anum SJ, Bouchier-Hayes LTranslational research : the journal of laboratory and clinical medicineThe NLRP3 inflammasome fires up heme-induced inflammation in hemolytic conditions. Transl Res. 2023 02; 252:34-44.Transl Res2022-08-28T00:00:002022The NLRP3 inflammasome fires up heme-induced inflammation in hemolytic conditions.true1Associate ProfessorAssociate ProfessorAuthorship 1214733Authorship 10540894Authorship 1067663337061332Sakthivel D, Brown-Suedel A, Bouchier-Hayes LAdvances in protein chemistry and structural biologyThe role of the nucleolus in regulating the cell cycle and the DNA damage response. Adv Protein Chem Struct Biol. 2023; 135:203-241.Adv Protein Chem Struct Biol2023-02-08T00:00:002023The role of the nucleolus in regulating the cell cycle and the DNA damage response.Authorship 129271Authorship 10733541337398413Sakthivel D, Brown-Suedel AN, Keane F, Huang S, Sherry KM, Charendoff CI, Dunne KP, Robichaux DJ, Le B, Shin CS, Carisey AF, Flanagan JM, Bouchier-Hayes LbioRxiv : the preprint server for biologyCaspase-2 is essential for proliferation and self-renewal of nucleophosmin-mutated acute myeloid leukemia. bioRxiv. 2023 May 30.bioRxiv2023-05-30T00:00:002023Caspase-2 is essential for proliferation and self-renewal of nucleophosmin-mutated acute myeloid leukemia.Authorship 1077535237691515Brown-Suedel AN, Bouchier-Hayes LThe EMBO journalGot PIDD1? Natural killer cells clear polyploid cells to ensure a balanced genome. EMBO J. 2023 10 16; 42(20):e115307.EMBO J2023-09-11T00:00:002023Got PIDD1? Natural killer cells clear polyploid cells to ensure a balanced genome.2025-05-31NIHBOUCHIER-HAYES, LISA2023-06-01Development of an in vitro system to study heme-induced caspase activationR03AI178641Principal Investigatortrue1ProfessorProfessortrue1ProfessorProfessortrue1ProfessorProfessortrue1ProfessorProfessortrue1ProfessorProfessorAuthorship 302721Authorship 463644Authorship 498853Authorship 837965Authorship 150923725060519Nishio N, Diaconu I, Liu H, Cerullo V, Caruana I, Hoyos V, Bouchier-Hayes L, Savoldo B, Dotti GCancer researchArmed oncolytic virus enhances immune functions of chimeric antigen receptor-modified T cells in solid tumors. Cancer Res. 2014 Sep 15; 74(18):5195-205.Cancer Res2014-07-24T00:00:002014Armed oncolytic virus enhances immune functions of chimeric antigen receptor-modified T cells in solid tumors.Authorship 618532Authorship 619789Authorship 936764Authorship 983361Authorship 793092Authorship 1554552Authorship 1554573Authorship 1554593Authorship 1562608