HUGO BELLEN to Drosophila melanogaster
This is a "connection" page, showing publications HUGO BELLEN has written about Drosophila melanogaster.
Connection Strength
14.622
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Using Drosophila to drive the diagnosis and understand the mechanisms of rare human diseases. Development. 2020 09 28; 147(21).
Score: 0.475
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The fruit fly at the interface of diagnosis and pathogenic mechanisms of rare and common human diseases. Hum Mol Genet. 2019 11 21; 28(R2):R207-R214.
Score: 0.448
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Ari-1 Regulates Myonuclear Organization Together with Parkin and Is Associated with Aortic Aneurysms. Dev Cell. 2018 04 23; 45(2):226-244.e8.
Score: 0.401
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A gene-specific T2A-GAL4 library for Drosophila. Elife. 2018 03 22; 7.
Score: 0.399
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The Krebs Cycle Enzyme Isocitrate Dehydrogenase 3A Couples Mitochondrial Metabolism to Synaptic Transmission. Cell Rep. 2017 12 26; 21(13):3794-3806.
Score: 0.393
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Drosophila tools and assays for the study of human diseases. Dis Model Mech. 2016 Mar; 9(3):235-44.
Score: 0.346
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WAC Regulates mTOR Activity by Acting as an Adaptor for the TTT and Pontin/Reptin Complexes. Dev Cell. 2016 Jan 25; 36(2):139-51.
Score: 0.344
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Morgan's legacy: fruit flies and the functional annotation of conserved genes. Cell. 2015 Sep 24; 163(1):12-4.
Score: 0.336
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A library of MiMICs allows tagging of genes and reversible, spatial and temporal knockdown of proteins in Drosophila. Elife. 2015 Mar 31; 4.
Score: 0.325
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Mitochondrial fusion but not fission regulates larval growth and synaptic development through steroid hormone production. Elife. 2014 Oct 14; 3.
Score: 0.314
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Large-scale identification of chemically induced mutations in Drosophila melanogaster. Genome Res. 2014 Oct; 24(10):1707-18.
Score: 0.314
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A drosophila genetic resource of mutants to study mechanisms underlying human genetic diseases. Cell. 2014 Sep 25; 159(1):200-214.
Score: 0.313
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The retromer complex is required for rhodopsin recycling and its loss leads to photoreceptor degeneration. PLoS Biol. 2014 Apr; 12(4):e1001847.
Score: 0.305
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Drosophila Tempura, a novel protein prenyltransferase a subunit, regulates notch signaling via Rab1 and Rab11. PLoS Biol. 2014 Jan; 12(1):e1001777.
Score: 0.299
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Crag is a GEF for Rab11 required for rhodopsin trafficking and maintenance of adult photoreceptor cells. PLoS Biol. 2012; 10(12):e1001438.
Score: 0.276
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A mutation in EGF repeat-8 of Notch discriminates between Serrate/Jagged and Delta family ligands. Science. 2012 Nov 30; 338(6111):1229-32.
Score: 0.276
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Probing mechanisms that underlie human neurodegenerative diseases in Drosophila. Annu Rev Genet. 2012; 46:371-96.
Score: 0.272
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Genome-wide manipulations of Drosophila melanogaster with transposons, Flp recombinase, and FC31 integrase. Methods Mol Biol. 2012; 859:203-28.
Score: 0.259
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Genetic manipulation of genes and cells in the nervous system of the fruit fly. Neuron. 2011 Oct 20; 72(2):202-30.
Score: 0.256
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MiMIC: a highly versatile transposon insertion resource for engineering Drosophila melanogaster genes. Nat Methods. 2011 Sep; 8(9):737-43.
Score: 0.253
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The Drosophila gene disruption project: progress using transposons with distinctive site specificities. Genetics. 2011 Jul; 188(3):731-43.
Score: 0.247
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A synaptic vesicle-associated Ca2+ channel promotes endocytosis and couples exocytosis to endocytosis. Cell. 2009 Sep 04; 138(5):947-60.
Score: 0.221
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The Drosophila deoxyhypusine hydroxylase homologue nero and its target eIF5A are required for cell growth and the regulation of autophagy. J Cell Biol. 2009 Jun 29; 185(7):1181-94.
Score: 0.218
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The Arp2/3 complex and WASp are required for apical trafficking of Delta into microvilli during cell fate specification of sensory organ precursors. Nat Cell Biol. 2009 Jul; 11(7):815-24.
Score: 0.218
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Sequoia regulates cell fate decisions in the external sensory organs of adult Drosophila. EMBO Rep. 2009 Jun; 10(6):636-41.
Score: 0.216
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Ero1L, a thiol oxidase, is required for Notch signaling through cysteine bridge formation of the Lin12-Notch repeats in Drosophila melanogaster. J Cell Biol. 2008 Sep 22; 182(6):1113-25.
Score: 0.207
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Huntingtin-interacting protein 14, a palmitoyl transferase required for exocytosis and targeting of CSP to synaptic vesicles. J Cell Biol. 2007 Dec 31; 179(7):1481-96.
Score: 0.196
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Transgenesis upgrades for Drosophila melanogaster. Development. 2007 Oct; 134(20):3571-84.
Score: 0.193
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P[acman]: a BAC transgenic platform for targeted insertion of large DNA fragments in D. melanogaster. Science. 2006 Dec 15; 314(5806):1747-51.
Score: 0.182
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Internalization is required for proper Wingless signaling in Drosophila melanogaster. J Cell Biol. 2006 Apr 10; 173(1):95-106.
Score: 0.174
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The nicotinic acetylcholine receptor Dalpha7 is required for an escape behavior in Drosophila. PLoS Biol. 2006 Mar; 4(3):e63.
Score: 0.173
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Fighting anthrax with flies. Proc Natl Acad Sci U S A. 2006 Feb 28; 103(9):3013-4.
Score: 0.173
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Aberrant lysosomal carbohydrate storage accompanies endocytic defects and neurodegeneration in Drosophila benchwarmer. J Cell Biol. 2005 Jul 04; 170(1):127-39.
Score: 0.165
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The v-ATPase V0 subunit a1 is required for a late step in synaptic vesicle exocytosis in Drosophila. Cell. 2005 May 20; 121(4):607-620.
Score: 0.164
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Emerging technologies for gene manipulation in Drosophila melanogaster. Nat Rev Genet. 2005 Mar; 6(3):167-78.
Score: 0.161
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Flying in the face of total disruption. Nat Genet. 2004 Mar; 36(3):211-2.
Score: 0.151
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Integrating non-mammalian model organisms in the diagnosis of rare genetic diseases in humans. Nat Rev Genet. 2024 Jan; 25(1):46-60.
Score: 0.144
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The Voltage-Gated Sodium Channel in Drosophila, Para, Localizes to Dendrites As Well As Axons in Mechanosensitive Chordotonal Neurons. eNeuro. 2023 Jun; 10(6).
Score: 0.144
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Aging Fly Cell Atlas identifies exhaustive aging features at cellular resolution. Science. 2023 06 16; 380(6650):eadg0934.
Score: 0.143
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Meaningless minis? Mechanisms of neurotransmitter-receptor clustering. Trends Neurosci. 2002 Aug; 25(8):383-5.
Score: 0.135
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Drosophila VAP-33A directs bouton formation at neuromuscular junctions in a dosage-dependent manner. Neuron. 2002 Jul 18; 35(2):291-306.
Score: 0.135
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'Fly-ing' from rare to common neurodegenerative disease mechanisms. Trends Genet. 2022 09; 38(9):972-984.
Score: 0.132
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Endophilin mutations block clathrin-mediated endocytosis but not neurotransmitter release. Cell. 2002 Apr 05; 109(1):101-12.
Score: 0.132
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Low doses of the organic insecticide spinosad trigger lysosomal defects, elevated ROS, lipid dysregulation, and neurodegeneration in flies. Elife. 2022 02 22; 11.
Score: 0.131
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Hrs regulates endosome membrane invagination and tyrosine kinase receptor signaling in Drosophila. Cell. 2002 Jan 25; 108(2):261-9.
Score: 0.130
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Mutations affecting the development of the peripheral nervous system in Drosophila: a molecular screen for novel proteins. Genetics. 2000 Dec; 156(4):1691-715.
Score: 0.120
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Low doses of the neonicotinoid insecticide imidacloprid induce ROS triggering neurological and metabolic impairments in Drosophila. Proc Natl Acad Sci U S A. 2020 10 13; 117(41):25840-25850.
Score: 0.119
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Mutations in ANKLE2, a ZIKA Virus Target, Disrupt an Asymmetric Cell Division Pathway in Drosophila Neuroblasts to Cause Microcephaly. Dev Cell. 2019 12 16; 51(6):713-729.e6.
Score: 0.112
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A putative exchange factor for Rho1 GTPase is required for initiation of cytokinesis in Drosophila. Genes Dev. 1999 Sep 01; 13(17):2301-14.
Score: 0.110
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cindr, the Drosophila Homolog of the CD2AP Alzheimer's Disease Risk Gene, Is Required for Synaptic Transmission and Proteostasis. Cell Rep. 2019 08 13; 28(7):1799-1813.e5.
Score: 0.110
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Using Drosophila to study mechanisms of hereditary hearing loss. Dis Model Mech. 2018 05 31; 11(6).
Score: 0.101
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The Glia-Neuron Lactate Shuttle and Elevated ROS Promote Lipid Synthesis in Neurons and Lipid Droplet Accumulation in Glia via APOE/D. Cell Metab. 2017 Nov 07; 26(5):719-737.e6.
Score: 0.096
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Loss of Nardilysin, a Mitochondrial Co-chaperone for a-Ketoglutarate Dehydrogenase, Promotes mTORC1 Activation and Neurodegeneration. Neuron. 2017 Jan 04; 93(1):115-131.
Score: 0.091
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Missense variants in the middle domain of DNM1L in cases of infantile encephalopathy alter peroxisomes and mitochondria when assayed in Drosophila. Hum Mol Genet. 2016 05 01; 25(9):1846-56.
Score: 0.086
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FlyBase: a virtual Drosophila cornucopia. Trends Genet. 1995 Nov; 11(11):456-7.
Score: 0.085
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Pri sORF peptides induce selective proteasome-mediated protein processing. Science. 2015 Sep 18; 349(6254):1356-8.
Score: 0.084
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The retromer complex in development and disease. Development. 2015 Jul 15; 142(14):2392-6.
Score: 0.083
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P-element mutations affecting embryonic peripheral nervous system development in Drosophila melanogaster. Genetics. 1995 Apr; 139(4):1663-78.
Score: 0.081
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A voltage-gated calcium channel regulates lysosomal fusion with endosomes and autophagosomes and is required for neuronal homeostasis. PLoS Biol. 2015 Mar; 13(3):e1002103.
Score: 0.081
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Huntingtin functions as a scaffold for selective macroautophagy. Nat Cell Biol. 2015 Mar; 17(3):262-75.
Score: 0.080
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Presynaptic proteins involved in exocytosis in Drosophila melanogaster: a genetic analysis. Invert Neurosci. 1995; 1(1):3-13.
Score: 0.080
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Mutations affecting the pattern of the PNS in Drosophila reveal novel aspects of neuronal development. Neuron. 1994 Aug; 13(2):269-87.
Score: 0.078
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Chemical mutagens, transposons, and transgenes to interrogate gene function in Drosophila melanogaster. Methods. 2014 Jun 15; 68(1):15-28.
Score: 0.075
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miR-9a minimizes the phenotypic impact of genomic diversity by buffering a transcription factor. Cell. 2013 Dec 19; 155(7):1556-67.
Score: 0.074
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The amyotrophic lateral sclerosis 8 protein, VAP, is required for ER protein quality control. Hum Mol Genet. 2014 Apr 15; 23(8):1975-89.
Score: 0.074
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Rhodopsin homeostasis and retinal degeneration: lessons from the fly. Trends Neurosci. 2013 Nov; 36(11):652-60.
Score: 0.073
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Protein phosphatase 1? limits ring canal constriction during Drosophila germline cyst formation. PLoS One. 2013; 8(7):e70502.
Score: 0.072
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The C8ORF38 homologue Sicily is a cytosolic chaperone for a mitochondrial complex I subunit. J Cell Biol. 2013 Mar 18; 200(6):807-20.
Score: 0.070
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Spectraplakins promote microtubule-mediated axonal growth by functioning as structural microtubule-associated proteins and EB1-dependent +TIPs (tip interacting proteins). J Neurosci. 2012 Jul 04; 32(27):9143-58.
Score: 0.067
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The Drosophila couch potato gene: an essential gene required for normal adult behavior. Genetics. 1992 Jun; 131(2):365-75.
Score: 0.067
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Drosophila P elements preferentially transpose to replication origins. Proc Natl Acad Sci U S A. 2011 Sep 20; 108(38):15948-53.
Score: 0.063
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A cis-regulatory map of the Drosophila genome. Nature. 2011 Mar 24; 471(7339):527-31.
Score: 0.061
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A molecularly defined duplication set for the X chromosome of Drosophila melanogaster. Genetics. 2010 Dec; 186(4):1111-25.
Score: 0.059
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P-element-mediated enhancer detection allows rapid identification of developmentally regulated genes and cell specific markers in Drosophila. J Physiol (Paris). 1990; 84(1):33-41.
Score: 0.056
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P-element-mediated enhancer detection: a versatile method to study development in Drosophila. Genes Dev. 1989 Sep; 3(9):1288-300.
Score: 0.055
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Versatile P[acman] BAC libraries for transgenesis studies in Drosophila melanogaster. Nat Methods. 2009 Jun; 6(6):431-4.
Score: 0.054
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A novel neuronal pathway for visually guided escape in Drosophila melanogaster. J Neurophysiol. 2009 Aug; 102(2):875-85.
Score: 0.054
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Importin 13 regulates neurotransmitter release at the Drosophila neuromuscular junction. J Neurosci. 2009 Apr 29; 29(17):5628-39.
Score: 0.054
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The amyotrophic lateral sclerosis 8 protein VAPB is cleaved, secreted, and acts as a ligand for Eph receptors. Cell. 2008 Jun 13; 133(6):963-77.
Score: 0.051
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straightjacket is required for the synaptic stabilization of cacophony, a voltage-gated calcium channel alpha1 subunit. J Cell Biol. 2008 Apr 07; 181(1):157-70.
Score: 0.050
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Two Drosophila learning mutants, dunce and rutabaga, provide evidence of a maternal role for cAMP on embryogenesis. Dev Biol. 1987 Jun; 121(2):432-44.
Score: 0.047
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Sexual hyperactivity and reduced longevity of dunce females of Drosophila melanogaster. Genetics. 1987 Jan; 115(1):153-60.
Score: 0.046
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The AXH domain of Ataxin-1 mediates neurodegeneration through its interaction with Gfi-1/Senseless proteins. Cell. 2005 Aug 26; 122(4):633-44.
Score: 0.042
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Cdk8/CDK19 promotes mitochondrial fission through Drp1 phosphorylation and can phenotypically suppress pink1 deficiency in Drosophila. Nat Commun. 2024 Apr 18; 15(1):3326.
Score: 0.038
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Drosophila parkin mutants have decreased mass and cell size and increased sensitivity to oxygen radical stress. Development. 2004 May; 131(9):2183-94.
Score: 0.038
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Synaptojanin is recruited by endophilin to promote synaptic vesicle uncoating. Neuron. 2003 Nov 13; 40(4):733-48.
Score: 0.037
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Numb: "Adapting" notch for endocytosis. Dev Cell. 2002 Aug; 3(2):155-6.
Score: 0.034
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ANKLE2-related microcephaly: A variable microcephaly syndrome resembling Zika infection. Ann Clin Transl Neurol. 2022 08; 9(8):1276-1288.
Score: 0.034
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Drosophila Crumbs is a positional cue in photoreceptor adherens junctions and rhabdomeres. Nature. 2002 Mar 14; 416(6877):178-83.
Score: 0.033
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Mapping and identification of essential gene functions on the X chromosome of Drosophila. EMBO Rep. 2002 Jan; 3(1):34-8.
Score: 0.032
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TNPO2 variants associate with human developmental delays, neurologic deficits, and dysmorphic features and alter TNPO2 activity in Drosophila. Am J Hum Genet. 2021 09 02; 108(9):1669-1691.
Score: 0.031
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Model organisms contribute to diagnosis and discovery in the undiagnosed diseases network: current state and a future vision. Orphanet J Rare Dis. 2021 05 07; 16(1):206.
Score: 0.031
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TFEB/Mitf links impaired nuclear import to autophagolysosomal dysfunction in C9-ALS. Elife. 2020 12 10; 9.
Score: 0.030
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BICRA, a SWI/SNF Complex Member, Is Associated with BAF-Disorder Related Phenotypes in Humans and Model Organisms. Am J Hum Genet. 2020 12 03; 107(6):1096-1112.
Score: 0.030
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De Novo Variants in CDK19 Are Associated with a Syndrome Involving Intellectual Disability and Epileptic Encephalopathy. Am J Hum Genet. 2020 05 07; 106(5):717-725.
Score: 0.029
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Loss of Oxidation Resistance 1, OXR1, Is Associated with an Autosomal-Recessive Neurological Disease with Cerebellar Atrophy and Lysosomal Dysfunction. Am J Hum Genet. 2019 12 05; 105(6):1237-1253.
Score: 0.028
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Disruptive mutations in TANC2 define a neurodevelopmental syndrome associated with psychiatric disorders. Nat Commun. 2019 10 15; 10(1):4679.
Score: 0.028
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De Novo Variants in WDR37 Are Associated with Epilepsy, Colobomas, Dysmorphism, Developmental Delay, Intellectual Disability, and Cerebellar Hypoplasia. Am J Hum Genet. 2019 08 01; 105(2):413-424.
Score: 0.027
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Ubiquilins regulate autophagic flux through mTOR signalling and lysosomal acidification. Nat Cell Biol. 2019 03; 21(3):384-396.
Score: 0.027
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Neuron-Subtype-Specific Expression, Interaction Affinities, and Specificity Determinants of DIP/Dpr Cell Recognition Proteins. Neuron. 2018 12 19; 100(6):1385-1400.e6.
Score: 0.026
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Visual impairment and progressive phthisis bulbi caused by recessive pathogenic variant in MARK3. Hum Mol Genet. 2018 08 01; 27(15):2703-2711.
Score: 0.026
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Functional variants in TBX2 are associated with a syndromic cardiovascular and skeletal developmental disorder. Hum Mol Genet. 2018 07 15; 27(14):2454-2465.
Score: 0.025
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pavarotti encodes a kinesin-like protein required to organize the central spindle and contractile ring for cytokinesis. Genes Dev. 1998 May 15; 12(10):1483-94.
Score: 0.025
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P-element insertion alleles of essential genes on the third chromosome of Drosophila melanogaster: mutations affecting embryonic PNS development. Genetics. 1997 Dec; 147(4):1723-41.
Score: 0.024
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Clinically severe CACNA1A alleles affect synaptic function and neurodegeneration differentially. PLoS Genet. 2017 Jul; 13(7):e1006905.
Score: 0.024
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Rare Functional Variant in TM2D3 is Associated with Late-Onset Alzheimer's Disease. PLoS Genet. 2016 Oct; 12(10):e1006327.
Score: 0.023
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Recurrent De Novo and Biallelic Variation of ATAD3A, Encoding a Mitochondrial Membrane Protein, Results in Distinct Neurological Syndromes. Am J Hum Genet. 2016 Oct 06; 99(4):831-845.
Score: 0.022
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Identification of immune system and response genes, and novel mutations causing melanotic tumor formation in Drosophila melanogaster. Genetics. 1996 Jun; 143(2):929-40.
Score: 0.022
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Ubr3, a Novel Modulator of Hh Signaling Affects the Degradation of Costal-2 and Kif7 through Poly-ubiquitination. PLoS Genet. 2016 05; 12(5):e1006054.
Score: 0.022
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FlyVar: a database for genetic variation in Drosophila melanogaster. Database (Oxford). 2015; 2015.
Score: 0.021
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Calcium dependence of neurotransmitter release and rate of spontaneous vesicle fusions are altered in Drosophila synaptotagmin mutants. Proc Natl Acad Sci U S A. 1994 Nov 08; 91(23):10888-92.
Score: 0.020
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rop, a Drosophila homolog of yeast Sec1 and vertebrate n-Sec1/Munc-18 proteins, is a negative regulator of neurotransmitter release in vivo. Neuron. 1994 Nov; 13(5):1099-108.
Score: 0.020
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A TRPV channel in Drosophila motor neurons regulates presynaptic resting Ca2+ levels, synapse growth, and synaptic transmission. Neuron. 2014 Nov 19; 84(4):764-77.
Score: 0.020
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Drosophila Ten-m and filamin affect motor neuron growth cone guidance. PLoS One. 2011; 6(8):e22956.
Score: 0.016
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Dissecting the complexity of the nervous system by enhancer detection. Bioessays. 1990 May; 12(5):199-204.
Score: 0.014
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P-element-mediated enhancer detection: an efficient method for isolating and characterizing developmentally regulated genes in Drosophila. Genes Dev. 1989 Sep; 3(9):1301-13.
Score: 0.014