Header Logo

Connection

BHAGAVATULA MOORTHY to Animals

Back to Details
This is a "connection" page, showing publications BHAGAVATULA MOORTHY has written about Animals.
BHAGAVATULA MOORTHY
Connection Strength
1.399
Animals
  1. Attenuation of Polycyclic Aromatic Hydrocarbon (PAH)-Induced Carcinogenesis and Tumorigenesis by Omega-3 Fatty Acids in Mice In Vivo. Int J Mol Sci. 2024 Mar 28; 25(7).
    View in: PubMed
    Score: 0.052
  2. Prenatal exposure to polycyclic aromatic hydrocarbons (PAHs) augments neonatal hyperoxic lung injury: Role of cytochrome P450 (CYP)1A1, 1A2, and 1B1. Free Radic Biol Med. 2024 02 01; 211:35-46.
    View in: PubMed
    Score: 0.051
  3. Loss of cytochrome P450 (CYP)1B1 mitigates hyperoxia response in adult mouse lung by reprogramming metabolism and translation. Redox Biol. 2023 08; 64:102790.
    View in: PubMed
    Score: 0.049
  4. The Aryl Hydrocarbon Receptor (AHR): A Novel Therapeutic Target for Pulmonary Diseases? Int J Mol Sci. 2022 Jan 28; 23(3).
    View in: PubMed
    Score: 0.045
  5. Molecular mechanisms of pulmonary carcinogenesis by polycyclic aromatic hydrocarbons (PAHs): Implications for human lung cancer. Semin Cancer Biol. 2021 11; 76:3-16.
    View in: PubMed
    Score: 0.043
  6. The role of cytochrome P450 (CYP) enzymes in hyperoxic lung injury. Expert Opin Drug Metab Toxicol. 2021 Feb; 17(2):171-178.
    View in: PubMed
    Score: 0.042
  7. Polycyclic Aromatic Hydrocarbon-induced Pulmonary Carcinogenesis in Cytochrome P450 (CYP)1A1- and 1A2-Null Mice: Roles of CYP1A1 and CYP1A2. Toxicol Sci. 2020 10 01; 177(2):347-361.
    View in: PubMed
    Score: 0.041
  8. Oxygen-mediated lung injury in mice lacking the gene for NRF2: Rescue with the cytochrome P4501A-inducer, beta-naphthoflavone (BNF), and differential sex-specific effects. Free Radic Biol Med. 2020 11 20; 160:208-218.
    View in: PubMed
    Score: 0.041
  9. Mice Lacking the Cytochrome P450 1B1 Gene Are Less Susceptible to Hyperoxic Lung Injury Than Wild Type. Toxicol Sci. 2018 10 01; 165(2):462-474.
    View in: PubMed
    Score: 0.036
  10. Role of Cytochrome P450 (CYP)1A in Hyperoxic Lung Injury: Analysis of the Transcriptome and Proteome. Sci Rep. 2017 04 04; 7(1):642.
    View in: PubMed
    Score: 0.032
  11. Sex-specific differences in neonatal hyperoxic lung injury. Am J Physiol Lung Cell Mol Physiol. 2016 Aug 01; 311(2):L481-93.
    View in: PubMed
    Score: 0.030
  12. Mechanistic role of cytochrome P450 (CYP)1B1 in oxygen-mediated toxicity in pulmonary cells: A novel target for prevention of hyperoxic lung injury. Biochem Biophys Res Commun. 2016 08 05; 476(4):346-351.
    View in: PubMed
    Score: 0.030
  13. In Vitro Approaches to Study Regulation of Hepatic Cytochrome P450 (CYP) 3A Expression by Paclitaxel and Rifampicin. Methods Mol Biol. 2016; 1395:55-68.
    View in: PubMed
    Score: 0.029
  14. Can maternal DHA supplementation offer long-term protection against neonatal hyperoxic lung injury? Am J Physiol Lung Cell Mol Physiol. 2015 Dec 15; 309(12):L1383-6.
    View in: PubMed
    Score: 0.029
  15. Omeprazole Attenuates Pulmonary Aryl Hydrocarbon Receptor Activation and Potentiates Hyperoxia-Induced Developmental Lung Injury in Newborn Mice. Toxicol Sci. 2015 Nov; 148(1):276-87.
    View in: PubMed
    Score: 0.029
  16. Detection of Bulky Endogenous Oxidative DNA Lesions Derived from 8,5'-Cyclo-2'-deoxyadenosine by ??P-Postlabeling Assay. Curr Protoc Toxicol. 2015 May 04; 64:17.17.1-17.17.14.
    View in: PubMed
    Score: 0.028
  17. Sex-specific differences in hyperoxic lung injury in mice: role of cytochrome P450 (CYP)1A. Toxicology. 2015 May 04; 331:14-23.
    View in: PubMed
    Score: 0.028
  18. Disruption of cytochrome P4501A2 in mice leads to increased susceptibility to hyperoxic lung injury. Free Radic Biol Med. 2015 May; 82:147-59.
    View in: PubMed
    Score: 0.028
  19. Analysis of the transcriptome in hyperoxic lung injury and sex-specific alterations in gene expression. PLoS One. 2014; 9(7):e101581.
    View in: PubMed
    Score: 0.027
  20. Mice deficient in the gene for cytochrome P450 (CYP)1A1 are more susceptible than wild-type to hyperoxic lung injury: evidence for protective role of CYP1A1 against oxidative stress. Toxicol Sci. 2014 Sep; 141(1):68-77.
    View in: PubMed
    Score: 0.026
  21. Sex-specific differences in hyperoxic lung injury in mice: implications for acute and chronic lung disease in humans. Toxicol Appl Pharmacol. 2013 Oct 15; 272(2):281-90.
    View in: PubMed
    Score: 0.025
  22. Functional deficiency of aryl hydrocarbon receptor augments oxygen toxicity-induced alveolar simplification in newborn mice. Toxicol Appl Pharmacol. 2013 Mar 15; 267(3):209-17.
    View in: PubMed
    Score: 0.024
  23. Effects of dietary fish oil on the depletion of carcinogenic PAH-DNA adduct levels in the liver of B6C3F1 mouse. PLoS One. 2011; 6(10):e26589.
    View in: PubMed
    Score: 0.022
  24. Omeprazole attenuates hyperoxic lung injury in mice via aryl hydrocarbon receptor activation and is associated with increased expression of cytochrome P4501A enzymes. J Pharmacol Exp Ther. 2011 Oct; 339(1):106-14.
    View in: PubMed
    Score: 0.022
  25. Prenatal administration of the cytochrome P4501A inducer, ?-naphthoflavone (BNF), attenuates hyperoxic lung injury in newborn mice: implications for bronchopulmonary dysplasia (BPD) in premature infants. Toxicol Appl Pharmacol. 2011 Oct 15; 256(2):83-94.
    View in: PubMed
    Score: 0.022
  26. Augmented oxygen-mediated transcriptional activation of cytochrome P450 (CYP)1A expression and increased susceptibilities to hyperoxic lung injury in transgenic mice carrying the human CYP1A1 or mouse 1A2 promoter in vivo. Biochem Biophys Res Commun. 2011 Apr 01; 407(1):79-85.
    View in: PubMed
    Score: 0.021
  27. Disruption of the gene for CYP1A2, which is expressed primarily in liver, leads to differential regulation of hepatic and pulmonary mouse CYP1A1 expression and augmented human CYP1A1 transcriptional activation in response to 3-methylcholanthrene in vivo. J Pharmacol Exp Ther. 2010 Nov; 335(2):369-79.
    View in: PubMed
    Score: 0.020
  28. Persistent induction of cytochrome P450 (CYP)1A enzymes by 3-methylcholanthrene in vivo in mice is mediated by sustained transcriptional activation of the corresponding promoters. Biochem Biophys Res Commun. 2009 Dec 25; 390(4):1419-24.
    View in: PubMed
    Score: 0.019
  29. Persistent induction of hepatic and pulmonary phase II enzymes by 3-methylcholanthrene in rats. Toxicol Sci. 2008 Apr; 102(2):337-44.
    View in: PubMed
    Score: 0.017
  30. 3-Methylcholanthrene elicits DNA adduct formation in the CYP1A1 promoter region and attenuates reporter gene expression in rat H4IIE cells. Biochem Biophys Res Commun. 2007 Mar 23; 354(4):1071-7.
    View in: PubMed
    Score: 0.016
  31. Modulation of pulmonary cytochrome P4501A1 expression by hyperoxia and inhaled nitric oxide in the newborn rat: implications for lung injury. Pediatr Res. 2006 Mar; 59(3):401-6.
    View in: PubMed
    Score: 0.015
  32. Attenuation of oxygen-induced abnormal lung maturation in rats by retinoic acid: possible role of cytochrome P4501A enzymes. J Pharmacol Exp Ther. 2006 Jun; 317(3):946-54.
    View in: PubMed
    Score: 0.015
  33. Effects of 3-methylcholanthrene on gene expression profiling in the rat using cDNA microarray analyses. Chem Res Toxicol. 2005 Nov; 18(11):1634-41.
    View in: PubMed
    Score: 0.015
  34. Attenuation of hyperoxic lung injury by the CYP1A inducer beta-naphthoflavone. Toxicol Sci. 2005 Sep; 87(1):204-12.
    View in: PubMed
    Score: 0.014
  35. Bioactivation of polycyclic aromatic hydrocarbon carcinogens within the vascular wall: implications for human atherogenesis. Drug Metab Rev. 2005; 37(4):595-610.
    View in: PubMed
    Score: 0.014
  36. Disruption of the Ah receptor gene alters the susceptibility of mice to oxygen-mediated regulation of pulmonary and hepatic cytochromes P4501A expression and exacerbates hyperoxic lung injury. J Pharmacol Exp Ther. 2004 Aug; 310(2):512-9.
    View in: PubMed
    Score: 0.013
  37. Loss of microRNA-30a and sex-specific effects on the neonatal hyperoxic lung injury. Biol Sex Differ. 2023 08 08; 14(1):50.
    View in: PubMed
    Score: 0.012
  38. Loss of growth differentiation factor 15 exacerbates lung injury in neonatal mice. Am J Physiol Lung Cell Mol Physiol. 2023 09 01; 325(3):L314-L326.
    View in: PubMed
    Score: 0.012
  39. Role of cytochrome P4501B1 in benzo[a]pyrene bioactivation to DNA-binding metabolites in mouse vascular smooth muscle cells: evidence from 32P-postlabeling for formation of 3-hydroxybenzo[a]pyrene and benzo[a]pyrene-3,6-quinone as major proximate genotoxic intermediates. J Pharmacol Exp Ther. 2003 Apr; 305(1):394-401.
    View in: PubMed
    Score: 0.012
  40. Aryl hydrocarbon receptor maintains hepatic mitochondrial homeostasis in mice. Mol Metab. 2023 06; 72:101717.
    View in: PubMed
    Score: 0.012
  41. Polycyclic aromatic hydrocarbon-inducible DNA adducts: evidence by 32P-postlabeling and use of knockout mice for Ah receptor-independent mechanisms of metabolic activation in vivo. Int J Cancer. 2003 Jan 01; 103(1):5-11.
    View in: PubMed
    Score: 0.012
  42. Differential regulation of expression of hepatic and pulmonary cytochrome P4501A enzymes by 3-methylcholanthrene in mice lacking the CYP1A2 gene. J Pharmacol Exp Ther. 2002 Dec; 303(3):945-51.
    View in: PubMed
    Score: 0.012
  43. Cytochrome P450 1A1 is essential for the microbial metabolite, Urolithin A-mediated protection against colitis. Front Immunol. 2022; 13:1004603.
    View in: PubMed
    Score: 0.012
  44. Regulation of pulmonary and hepatic cytochrome P4501A expression in the rat by hyperoxia: implications for hyperoxic lung injury. Mol Pharmacol. 2002 Mar; 61(3):507-15.
    View in: PubMed
    Score: 0.011
  45. The atherogen 3-methylcholanthrene induces multiple DNA adducts in mouse aortic smooth muscle cells: role of cytochrome P4501B1. Cardiovasc Res. 2002 Mar; 53(4):1002-9.
    View in: PubMed
    Score: 0.011
  46. 3-Methylcholanthrene-inducible hepatic DNA adducts: a mechanistic hypothesis linking sequence-specific DNA adducts to sustained cytochrome P4501A1 induction by 3-methylcholanthrene. Redox Rep. 2002; 7(1):9-13.
    View in: PubMed
    Score: 0.011
  47. Effect of sex chromosomes versus hormones in neonatal lung injury. JCI Insight. 2021 07 08; 6(13).
    View in: PubMed
    Score: 0.011
  48. Epigenetic response to hyperoxia in the neonatal lung is sexually dimorphic. Redox Biol. 2020 10; 37:101718.
    View in: PubMed
    Score: 0.010
  49. Persistent expression of 3-methylcholanthrene-inducible cytochromes P4501A in rat hepatic and extrahepatic tissues. J Pharmacol Exp Ther. 2000 Jul; 294(1):313-22.
    View in: PubMed
    Score: 0.010
  50. Potentiation of oxygen-induced lung injury in rats by the mechanism-based cytochrome P-450 inhibitor, 1-aminobenzotriazole. J Pharmacol Exp Ther. 2000 Feb; 292(2):553-60.
    View in: PubMed
    Score: 0.010
  51. Impact of Early Life Antibiotic Exposure and Neonatal Hyperoxia on the Murine Microbiome and Lung Injury. Sci Rep. 2019 10 18; 9(1):14992.
    View in: PubMed
    Score: 0.010
  52. Transcriptomic profiling identifies novel mechanisms of transcriptional regulation of the cytochrome P450 (Cyp)3a11 gene. Sci Rep. 2019 04 30; 9(1):6663.
    View in: PubMed
    Score: 0.009
  53. ?-Naphthoflavone treatment attenuates neonatal hyperoxic lung injury in wild type and Cyp1a2-knockout mice. Toxicol Appl Pharmacol. 2018 01 15; 339:133-142.
    View in: PubMed
    Score: 0.008
  54. Sexual dimorphism of the pulmonary transcriptome in neonatal hyperoxic lung injury: identification of angiogenesis as a key pathway. Am J Physiol Lung Cell Mol Physiol. 2017 Dec 01; 313(6):L991-L1005.
    View in: PubMed
    Score: 0.008
  55. Newborn Mice Lacking the Gene for Cyp1a1 Are More Susceptible to Oxygen-Mediated Lung Injury, and Are Rescued by Postnatal ?-Naphthoflavone Administration: Implications for Bronchopulmonary Dysplasia in Premature Infants. Toxicol Sci. 2017 05 01; 157(1):260-271.
    View in: PubMed
    Score: 0.008
  56. Effects of cytochrome P450 inducers on tamoxifen genotoxicity in female mice in vivo. Biochem Pharmacol. 1997 Mar 07; 53(5):663-9.
    View in: PubMed
    Score: 0.008
  57. Involvement of the Bufadienolides in the Detection and Therapy of the Acute Respiratory Distress Syndrome. Lung. 2017 06; 195(3):323-332.
    View in: PubMed
    Score: 0.008
  58. Role of Toll-like receptor 4 in drug-drug interaction between paclitaxel and irinotecan in vitro. Toxicol In Vitro. 2017 Jun; 41:75-82.
    View in: PubMed
    Score: 0.008
  59. Regulation of drug-metabolizing enzymes in infectious and inflammatory disease: implications for biologics-small molecule drug interactions. Expert Opin Drug Metab Toxicol. 2017 Jun; 13(6):605-616.
    View in: PubMed
    Score: 0.008
  60. Leflunomide induces NAD(P)H quinone dehydrogenase 1 enzyme via the aryl hydrocarbon receptor in neonatal mice. Biochem Biophys Res Commun. 2017 03 25; 485(1):195-200.
    View in: PubMed
    Score: 0.008
  61. Induction and decline of hepatic cytochromes P4501A1 and 1A2 in rats exposed to hyperoxia are not paralleled by changes in glutathione S-transferase-alpha. Toxicol Lett. 1997 Jan 15; 90(1):67-75.
    View in: PubMed
    Score: 0.008
  62. Tamoxifen metabolic activation: comparison of DNA adducts formed by microsomal and chemical activation of tamoxifen and 4-hydroxytamoxifen with DNA adducts formed in vivo. Cancer Res. 1996 Jan 01; 56(1):53-7.
    View in: PubMed
    Score: 0.007
  63. Pentachlorophenol enhances 9-hydroxybenzo [a] pyrene-induced hepatic DNA adduct formation in vivo and inhibits microsomal epoxide hydrolase and glutathione S-transferase activities in vitro: likely inhibition of epoxide detoxication by pentachlorophenol. Arch Toxicol. 1996; 70(11):696-703.
    View in: PubMed
    Score: 0.007
  64. Effects of a single dose of the cytochrome P450 inducer, beta-naphthoflavone, on hepatic and renal covalent DNA modifications (I-compounds). Toxicology. 1995 Dec 15; 104(1-3):165-77.
    View in: PubMed
    Score: 0.007
  65. Evidence from 32P-postlabeling and the use of pentachlorophenol for a novel metabolic activation pathway of diethylstilbestrol and its dimethyl ether in mouse live: likely alpha-hydroxylation of ethyl group(s) followed by sulfate conjugation. Carcinogenesis. 1995 Nov; 16(11):2643-8.
    View in: PubMed
    Score: 0.007
  66. Role of Adaptor Protein Toll-Like Interleukin Domain Containing Adaptor Inducing Interferon ? in Toll-Like Receptor 3- and 4-Mediated Regulation of Hepatic Drug Metabolizing Enzyme and Transporter Genes. Drug Metab Dispos. 2016 Jan; 44(1):61-7.
    View in: PubMed
    Score: 0.007
  67. Leflunomide Induces Pulmonary and Hepatic CYP1A Enzymes via Aryl Hydrocarbon Receptor. Drug Metab Dispos. 2015 Dec; 43(12):1966-70.
    View in: PubMed
    Score: 0.007
  68. Differential concentration-specific effects of caffeine on cell viability, oxidative stress, and cell cycle in pulmonary oxygen toxicity in vitro. Biochem Biophys Res Commun. 2014 Aug 08; 450(4):1345-50.
    View in: PubMed
    Score: 0.007
  69. Mechanistic relationships between hepatic genotoxicity and carcinogenicity in male B6C3F1 mice treated with polycyclic aromatic hydrocarbon mixtures. Arch Toxicol. 2015 Jun; 89(6):967-77.
    View in: PubMed
    Score: 0.007
  70. Chemical structure- and time-dependent effects of polycyclic aromatic hydrocarbon-type inducers on rat liver cytochrome P450, DNA adducts, and I-compounds. Fundam Appl Toxicol. 1994 May; 22(4):549-60.
    View in: PubMed
    Score: 0.007
  71. Strong intensification of mouse hepatic tamoxifen DNA adduct formation by pretreatment with the sulfotransferase inhibitor and ubiquitous environmental pollutant pentachlorophenol. Carcinogenesis. 1994 May; 15(5):797-800.
    View in: PubMed
    Score: 0.007
  72. Increased susceptibility to hyperoxic lung injury and alveolar simplification in newborn rats by prenatal administration of benzo[a]pyrene. Toxicol Lett. 2014 Oct 15; 230(2):322-32.
    View in: PubMed
    Score: 0.007
  73. 3-Methylcholanthrene-inducible liver cytochrome(s) P450 in female Sprague-Dawley rats: possible link between P450 turnover and formation of DNA adducts and I-compounds. Carcinogenesis. 1993 May; 14(5):879-86.
    View in: PubMed
    Score: 0.006
  74. Chlorpromazine-induced hepatotoxicity during inflammation is mediated by TIRAP-dependent signaling pathway in mice. Toxicol Appl Pharmacol. 2013 Feb 01; 266(3):430-8.
    View in: PubMed
    Score: 0.006
  75. Drug disposition in pathophysiological conditions. Curr Drug Metab. 2012 Nov; 13(9):1327-44.
    View in: PubMed
    Score: 0.006
  76. CYP3A-dependent drug metabolism is reduced in bacterial inflammation in mice. Br J Pharmacol. 2012 Aug; 166(7):2176-87.
    View in: PubMed
    Score: 0.006
  77. Role of mammary epithelial and stromal P450 enzymes in the clearance and metabolic activation of 7,12-dimethylbenz(a)anthracene in mice. Toxicol Lett. 2012 Jul 20; 212(2):97-105.
    View in: PubMed
    Score: 0.006
  78. Sex-specific modulation of hepatic covalent DNA modifications (I-compounds) by the cytochrome P450 inducer, pregnenolone-16 alpha-carbonitrile. Toxicol Appl Pharmacol. 1992 Apr; 113(2):218-26.
    View in: PubMed
    Score: 0.006
  79. BALT development and augmentation of hyperoxic lung injury in mice deficient in NQO1 and NQO2. Free Radic Biol Med. 2006 May 15; 40(10):1843-56.
    View in: PubMed
    Score: 0.004
  80. Induction of CYP1A1 and CYP1B1 in liver and lung by benzo(a)pyrene and 7,12-d imethylbenz(a)anthracene do not affect distribution of polycyclic hydrocarbons to target tissue: role of AhR and CYP1B1 in bone marrow cytotoxicity. Toxicol Appl Pharmacol. 2005 Feb 01; 202(3):244-57.
    View in: PubMed
    Score: 0.003
  81. A Cyp1a2-luciferase transgenic CD-1 mouse model: responses to aryl hydrocarbons similar to the humanized AhR mice. Toxicol Sci. 2004 Nov; 82(1):297-307.
    View in: PubMed
    Score: 0.003
  82. Characterization of a major aromatic DNA adduct detected in human breast tissues. Environ Mol Mutagen. 2002; 39(2-3):193-200.
    View in: PubMed
    Score: 0.003
  83. Comparison of immunoaffinity chromatography enrichment and nuclease P1 procedures for 32P-postlabelling analysis of PAH-DNA adducts. Chem Biol Interact. 1998 Mar 12; 110(1-2):85-102.
    View in: PubMed
    Score: 0.002
  84. Acetaminophen binds to mouse hepatic and renal DNA at human therapeutic doses. Chem Res Toxicol. 1997 Apr; 10(4):470-6.
    View in: PubMed
    Score: 0.002
  85. Monophosphate 32P-postlabeling assay of DNA adducts from 1,2:3,4-diepoxybutane, the most genotoxic metabolite of 1,3-butadiene: in vitro methodological studies and in vivo dosimetry. Mutat Res. 1996 Nov 04; 371(1-2):87-104.
    View in: PubMed
    Score: 0.002
  86. Rapid decreases in indigenous covalent DNA modifications (I-compounds) of male Fischer-344 rat liver DNA by diquat treatment. Chem Biol Interact. 1995 Mar 30; 95(1-2):1-16.
    View in: PubMed
    Score: 0.002
  87. Tamoxifen: evidence by 32P-postlabeling and use of metabolic inhibitors for two distinct pathways leading to mouse hepatic DNA adduct formation and identification of 4-hydroxytamoxifen as a proximate metabolite. Carcinogenesis. 1994 Oct; 15(10):2087-94.
    View in: PubMed
    Score: 0.002
  88. I-compounds--endogenous DNA markers of nutritional status, ageing, tumour promotion and carcinogenesis. IARC Sci Publ. 1993; (124):157-65.
    View in: PubMed
    Score: 0.001
  89. Effects of cytochrome P450 inducers on I-compounds in rat liver and kidney DNA. Carcinogenesis. 1992 Jul; 13(7):1191-8.
    View in: PubMed
    Score: 0.001
Connection Strength

The connection strength for concepts is the sum of the scores for each matching publication.

Publication scores are based on many factors, including how long ago they were written and whether the person is a first or senior author.