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ALI MARIAN

TitleAdjunct Associate Professor
InstitutionBaylor College of Medicine
DepartmentDepartment of Medicine
Address6770 Bertner Avenue
Houston, TX 77030
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    Collapse Research 
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    R01AG082751     (MARIAN, ALI J)Aug 15, 2023 - Apr 30, 2028
    NIH
    Cytosolic DNA is the Link Between Genomic Instability and Cardiovascular Aging
    Role: Principal Investigator
    R01HL151737     (MARIAN, ALI J)Apr 10, 2020 - Mar 31, 2024
    NIH
    Cell type-Specific Therapeutic Targeting of canonical WNT Pathway in Arrhythmogenic Cardiomyopathy
    Role: Principal Investigator
    R01HL132401     (MARIAN, ALI J)Mar 15, 2016 - Jul 31, 2024
    NIH
    Mechanisms and Therapeutic Targeting of DNA Damage in Dilated Cardiomyopathy Caused by LMNA Mutations
    Role: Principal Investigator
    S10OD018135     (MARIAN, ALI J)Apr 1, 2015 - Mar 31, 2016
    NIH
    Cardiovascular Ultrasonography Unit
    Role: Principal Investigator
    R34HL105563     (MARIAN, ALI J)Jan 1, 2012 - Dec 31, 2016
    NIH
    Hypertrophy Regression with N-Acetylcysteine in Hypertrophic Cardiomyopathy
    Role: Principal Investigator
    R21AG038597     (MARIAN, ALI J)Apr 1, 2011 - Mar 31, 2013
    NIH
    Mouse Models of Non-Syndromic Cardiac Progeria
    Role: Principal Investigator
    R01HL088498     (MARIAN, ALI J)Jan 1, 2007 - Mar 31, 2019
    NIH
    Canonical Wnt Signaling in Pathogenesis and Rescue of ARVC
    Role: Principal Investigator
    R01HL068884     (MARIAN, ALI J.)Sep 30, 2001 - Jul 31, 2007
    NIH
    Modifier Genes of Familial Hypertrophic Cardiomyopathy
    Role: Principal Investigator

    Collapse Bibliographic 
    Collapse selected publications
    Publications listed below are automatically derived from MEDLINE/PubMed and other sources, which might result in incorrect or missing publications. Faculty can login to make corrections and additions.
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    PMC Citations indicate the number of times the publication was cited by articles in PubMed Central, and the Altmetric score represents citations in news articles and social media. (Note that publications are often cited in additional ways that are not shown here.) Fields are based on how the National Library of Medicine (NLM) classifies the publication's journal and might not represent the specific topic of the publication. Translation tags are based on the publication type and the MeSH terms NLM assigns to the publication. Some publications (especially newer ones and publications not in PubMed) might not yet be assigned Field or Translation tags.) Click a Field or Translation tag to filter the publications.
    1. Cathcart B, Cheedipudi SM, Rouhi L, Zhao Z, Gurha P, Marian AJ. DNA double-stranded breaks, a hallmark of aging, defined at the nucleotide resolution, are increased and associated with transcription in the cardiac myocytes in LMNA-cardiomyopathy. Cardiovasc Res. 2024 Apr 05. PMID: 38577741.
      Citations:    Fields:    
    2. Marian AJ. Editorial: Gene-based renaming of human diseases. Curr Opin Cardiol. 2024 May 01; 39(3):135-137. PMID: 38567947.
      Citations:    Fields:    
    3. Olcum M, Fan S, Rouhi L, Cheedipudi S, Cathcart B, Jeong HH, Zhao Z, Gurha P, Marian AJ, Olcum M, Fan S, Rouhi L, Cheedipudi S, Cathcart B, Jeong HH, Zhao Z, Gurha P, Marian AJ. Genetic inactivation of ?-catenin is salubrious, whereas its activation is deleterious in desmoplakin cardiomyopathy. Cardiovasc Res. 2023 12 30; 119(17):2712-2728. PMID: 37625794.
      Citations:    Fields:    Translation:Animals
    4. Franco A, Li J, Kelly DP, Hershberger RE, Marian AJ, Lewis RM, Song M, Dang X, Schmidt AD, Mathyer ME, Edwards JR, Strong CG, Dorn GW. A human mitofusin 2 mutation can cause mitophagic cardiomyopathy. Elife. 2023 11 01; 12. PMID: 37910431; PMCID: PMC10619978.
      Citations: 2     Fields:    Translation:HumansAnimals
    5. Rouhi L, Cheedipudi SM, Cathcart B, Gurha P, Marian AJ. Cytosolic DNA sensing protein pathway is activated in human hearts with dilated cardiomyopathy. J Cardiovasc Aging. 2023; 3(3). PMID: 37577061; PMCID: PMC10421632.
      Citations:    
    6. Gurha P, Ishaq N, Marian AJ. ChatGPT and other artificial intelligence chatbots and biomedical writing. J Cardiovasc Aging. 2023; 3(2). PMID: 37092015; PMCID: PMC10121201.
      Citations:    
    7. Marian AJ. What ails the NIH peer review study sections and how to fix the review process of the grant applications. J Cardiovasc Aging. 2023 Feb; 3(1). PMID: 36818427; PMCID: PMC9933949.
      Citations:    
    8. Spindler V, Gerull B, Green KJ, Kowalczyk AP, Leube R, Marian AJ, Milting H, M?ller EJ, Niessen C, Payne AS, Schlegel N, Schmidt E, Strnad P, Tikkanen R, Vielmuth F, Waschke J. Meeting report - Desmosome dysfunction and disease: Alpine desmosome disease meeting. J Cell Sci. 2023 01 01; 136(1). PMID: 36594662.
      Citations: 2     Fields:    Translation:HumansCells
    9. Olcum M, Rouhi L, Fan S, Gonzales MM, Jeong HH, Zhao Z, Gurha P, Marian AJ. PANoptosis is a prominent feature of desmoplakin cardiomyopathy. J Cardiovasc Aging. 2023 Feb; 3(1). PMID: 36818425; PMCID: PMC9933912.
      Citations: 1     
    10. Cheedipudi SM, Asghar S, Marian AJ. Genetic Ablation of the DNA Damage Response Pathway Attenuates Lamin-Associated Dilated Cardiomyopathy in Mice. JACC Basic Transl Sci. 2022 Dec; 7(12):1232-1245. PMID: 36644279; PMCID: PMC9831927.
      Citations: 2     
    11. Marian AJ. Sporadic dilated cardiomyopathy is often familial. Cardiovasc Res. 2022 07 27; 118(10):e69-e71. PMID: 35726845; PMCID: PMC9890628.
      Citations:    
    12. Marian AJ. Mutant SRF and YAP1 remodel the chromatin to entice cardiac myocyte nuclear division. J Cardiovasc Aging. 2022 Jul; 2(3). PMID: 35891704; PMCID: PMC9311337.
      Citations:    
    13. Rouhi L, Auguste G, Zhou Q, Lombardi R, Olcum M, Pourebrahim K, Cheedipudi SM, Asghar S, Hong K, Robertson MJ, Coarfa C, Gurha P, Marian AJ. Deletion of the Lmna gene in fibroblasts causes senescence-associated dilated cardiomyopathy by activating the double-stranded DNA damage response and induction of senescence-associated secretory phenotype. J Cardiovasc Aging. 2022 Jul; 2(3). PMID: 35891706; PMCID: PMC9311325.
      Citations:    
    14. Rouhi L, Fan S, Cheedipudi SM, Yao Y, Robertson MJ, Coarfa C, Gimeno JR, Gurha P, Marian AJ, Braza-Bo?ls A, Molina MS, Molina P, Zorio E. The EP300/TP53 pathway, a suppressor of the Hippo and canonical WNT pathways, is activated in human hearts with arrhythmogenic cardiomyopathy in the absence of overt heart failure. Cardiovasc Res. 2022 05 06; 118(6):1466-1478. PMID: 34132777; PMCID: PMC9074970.
      Citations: 4     Fields:    Translation:HumansCells
    15. Marian AJ. Genetic basis of cardiovascular aging is at the core of human longevity. J Cardiovasc Aging. 2022; 2(2). PMID: 35531366; PMCID: PMC9075051.
      Citations:    
    16. Olcum M, Cheedipudi SM, Rouhi L, Fan S, Jeong HH, Zhao Z, Gurha P, Marian AJ. The WNT/?-catenin pathway regulates expression of the genes involved in cell cycle progression and mitochondrial oxidative phosphorylation in the postmitotic cardiac myocytes. J Cardiovasc Aging. 2022; 2(2). PMID: 35224561; PMCID: PMC8874274.
      Citations:    
    17. Rouhi L, Fan S, Cheedipudi SM, Olcum M, Jeong HH, Zhao Z, Gurha P, Marian AJ. Effects of tamoxifen inducible MerCreMer on gene expression in cardiac myocytes in mice. J Cardiovasc Aging. 2022; 2. PMID: 35079750; PMCID: PMC8785140.
      Citations:    
    18. Marian AJ. Oligogenic cardiomyopathy. J Cardiovasc Aging. 2022; 2. PMID: 34841425; PMCID: PMC8623865.
      Citations:    
    19. Marian AJ. Principles of scientific research conduct, peer review, and publication: an editor's perspective. J Cardiovasc Aging. 2022; 2. PMID: 35037003; PMCID: PMC8756452.
      Citations:    
    20. Sun Y, Xiao L, Li K, Wang H, Song X, Li Z, Li C, Chen Y, Li S, Huang J, Tan L, Hu D, Yu T, Li R, Jin L, Shi L, Marian AJ, Wang DW. Shared Genetic Etiology of Primary Dilated Cardiomyopathy and Ischemic Dilated Cardiomyopathy. Front Cardiovasc Med. 2021; 8:752662. PMID: 37273834; PMCID: PMC10236477.
      Citations:    
    21. Rouhi L, Cheedipudi SM, Chen SN, Fan S, Lombardi R, Chen X, Coarfa C, Robertson MJ, Gurha P, Marian AJ. Haploinsufficiency of Tmem43 in cardiac myocytes activates the DNA damage response pathway leading to a late-onset senescence-associated pro-fibrotic cardiomyopathy. Cardiovasc Res. 2021 09 28; 117(11):2377-2394. PMID: 33070193; PMCID: PMC8861264.
      Citations: 11     Fields:    Translation:AnimalsCells
    22. Pourebrahim K, Marian JG, Tan Y, Chang JT, Marian AJ. A combinatorial oligogenic basis for the phenotypic plasticity between late-onset dilated and arrhythmogenic cardiomyopathy in a single family. J Cardiovasc Aging. 2021; 1. PMID: 34790974; PMCID: PMC8594872.
      Citations:    
    23. Cheedipudi SM, Fan S, Rouhi L, Marian AJ. Pharmacological suppression of the WNT signaling pathway attenuates age-dependent expression of the phenotype in a mouse model of arrhythmogenic cardiomyopathy. J Cardiovasc Aging. 2021; 1(3). PMID: 34447973; PMCID: PMC8386676.
      Citations:    
    24. Marian AJ. Editorial: Cardiovascular complications of COVID-19. Curr Opin Cardiol. 2021 05 01; 36(3):253-255. PMID: 33605618; PMCID: PMC8208479.
      Citations:    Fields:    Translation:HumansCells
    25. Xiao L, Li C, Sun Y, Chen Y, Wei H, Hu D, Yu T, Li X, Jin L, Shi L, Marian AJ, Wang DW. Clinical Significance of Variants in the TTN Gene in a Large Cohort of Patients With Sporadic Dilated Cardiomyopathy. Front Cardiovasc Med. 2021; 8:657689. PMID: 33996946; PMCID: PMC8120103.
      Citations:    
    26. Marian AJ, Asatryan B, Bolli R, Cheedipudi SM, Dhalla NS, Finkel T, Frangogiannis NG, Gurha P, Belmonte JCI, Hare JM, Hong K, Kirshenbaum LA, Lee RT, Leesar MA, Libby P, Madonna R, Nagueh SF, Roberts R, Rosenzweig A, Rouhi L, Sadoshima J, Sussman MA, Taffet GE, Tanaka H, Torella D, Wang Y, Wang DW. Editors' Preamble to The Journal of Cardiovascular Aging. J Cardiovasc Aging. 2021; 1. PMID: 34327514; PMCID: PMC8318349.
      Citations:    
    27. Yuan P, Cheedipudi SM, Rouhi L, Fan S, Simon L, Zhao Z, Hong K, Gurha P, Marian AJ. Single-Cell RNA Sequencing Uncovers Paracrine Functions of the Epicardial-Derived Cells in Arrhythmogenic Cardiomyopathy. Circulation. 2021 06; 143(22):2169-2187. PMID: 33726497; PMCID: PMC8169643.
      Citations: 4     Fields:    Translation:HumansAnimals
    28. Li R, Wang H, Ma F, Cui GL, Peng LY, Li CZ, Zeng HS, Marian AJ, Wang DW. Widespread myocardial dysfunction in COVID-19 patients detected by myocardial strain imaging using 2-D speckle-tracking echocardiography. Acta Pharmacol Sin. 2021 Oct; 42(10):1567-1574. PMID: 33510459; PMCID: PMC7842392.
      Citations: 16     Fields:    Translation:Humans
    29. Liu X, Ge J, Chen C, Shen Y, Xie J, Zhu X, Liu M, Hu J, Chen L, Guo L, Zhou Q, Yan X, Qiu Y, Wan R, Marian AJ, Hong K. FAT10 protects against ischemia-induced ventricular arrhythmia by decreasing Nedd4-2/Nav1.5 complex formation. Cell Death Dis. 2021 01 05; 12(1):25. PMID: 33414395; PMCID: PMC7790828.
      Citations: 3     Fields:    Translation:HumansCells
    30. Marian AJ, Ad?o R. Highlights of American Heart Association Scientific Sessions 2020: a virtual experience. Cardiovasc Res. 2021 01 01; 117(1):e10-e12. PMID: 33426562; PMCID: PMC7810125.
      Citations:    Fields:    Translation:HumansCells
    31. Marian AJ. Clinical Interpretation and Management of Genetic Variants. JACC Basic Transl Sci. 2020 Oct; 5(10):1029-1042. PMID: 33145465; PMCID: PMC7591931.
      Citations: 8     
    32. Marian AJ. Current state of vaccine development and targeted therapies for COVID-19: impact of basic science discoveries. Cardiovasc Pathol. 2021 Jan - Feb; 50:107278. PMID: 32889088; PMCID: PMC7462898.
      Citations: 20     Fields:    Translation:HumansAnimalsCells
    33. Auguste G, Rouhi L, Matkovich SJ, Coarfa C, Robertson MJ, Czernuszewicz G, Gurha P, Marian AJ. BET bromodomain inhibition attenuates cardiac phenotype in myocyte-specific lamin A/C-deficient mice. J Clin Invest. 2020 09 01; 130(9):4740-4758. PMID: 32484798; PMCID: PMC7456228.
      Citations: 16     Fields:    Translation:AnimalsCells
    34. Guzik TJ, Mohiddin SA, Dimarco A, Patel V, Savvatis K, Marelli-Berg FM, Madhur MS, Tomaszewski M, Maffia P, D'Acquisto F, Nicklin SA, Marian AJ, Nosalski R, Murray EC, Guzik B, Berry C, Touyz RM, Wang DW, Bhella D, Sagliocco O, Crea F, Thomson EC, McInnes IB, Kreutz R. COVID-19 and the cardiovascular system: implications for risk assessment, diagnosis, and treatment options. Cardiovasc Res. 2020 08 01; 116(10):1666-1687. PMID: 32352535; PMCID: PMC7197627.
      Citations: 464     Fields:    Translation:HumansCellsPHPublic Health
    35. Coste Pradas J, Auguste G, Matkovich SJ, Lombardi R, Chen SN, Garnett T, Chamberlain K, Riyad JM, Weber T, Singh SK, Robertson MJ, Coarfa C, Marian AJ, Gurha P. Identification of Genes and Pathways Regulated by Lamin A in Heart. J Am Heart Assoc. 2020 08 18; 9(16):e015690. PMID: 32805188; PMCID: PMC7660829.
      Citations: 2     Fields:    Translation:Animals
    36. Marian AJ, Asatryan B, Wehrens XHT. Genetic basis and molecular biology of cardiac arrhythmias in cardiomyopathies. Cardiovasc Res. 2020 07 15; 116(9):1600-1619. PMID: 32348453; PMCID: PMC7341170.
      Citations: 16     Fields:    Translation:HumansAnimals
    37. Ho CY, Mealiffe ME, Bach RG, Bhattacharya M, Choudhury L, Edelberg JM, Hegde SM, Jacoby D, Lakdawala NK, Lester SJ, Ma Y, Marian AJ, Nagueh SF, Owens A, Rader F, Saberi S, Sehnert AJ, Sherrid MV, Solomon SD, Wang A, Wever-Pinzon O, Wong TC, Heitner SB. Evaluation of Mavacamten in Symptomatic Patients With Nonobstructive Hypertrophic Cardiomyopathy. J Am Coll Cardiol. 2020 06 02; 75(21):2649-2660. PMID: 32466879.
      Citations: 31     Fields:    Translation:HumansCTClinical Trials
    38. Marian AJ. Editorial: Overcoming current limitations of genetic testing in cardiovascular medicine. Curr Opin Cardiol. 2020 05; 35(3):187-190. PMID: 32175937.
      Citations:    Fields:    Translation:Humans
    39. Cheedipudi SM, Hu J, Fan S, Yuan P, Karmouch J, Czernuszewicz G, Robertson MJ, Coarfa C, Hong K, Yao Y, Campbell H, Wehrens X, Gurha P, Marian AJ. Exercise restores dysregulated gene expression in a mouse model of arrhythmogenic cardiomyopathy. Cardiovasc Res. 2020 05 01; 116(6):1199-1213. PMID: 31350552; PMCID: PMC7177479.
      Citations: 22     Fields:    Translation:AnimalsCells
    40. Puzzi L, Borin D, Gurha P, Lombardi R, Martinelli V, Weiss M, Andolfi L, Lazzarino M, Mestroni L, Marian AJ, Sbaizero O. Knock Down of Plakophillin 2 Dysregulates Adhesion Pathway through Upregulation of miR200b and Alters the Mechanical Properties in Cardiac Cells. Cells. 2019 12 14; 8(12). PMID: 31847412; PMCID: PMC6952926.
      Citations: 10     Fields:    Translation:AnimalsCells
    41. Hall CL, Gurha P, Asimaki A, Futema M, Lovering RC, Aguilera B, Coarfa C, Robertson MJ, Cheedipudi SM, Ng KE, Delaney P, Gimeno JR, McKenna WJ, Marian AJ, Syrris P, Sabater-Molina M, Su?rez MP, Molina P, Zorio E, Hern?ndez JP, Pastor F. RNA sequencing-based transcriptome profiling of cardiac tissue implicates novel putative disease mechanisms in FLNC-associated arrhythmogenic cardiomyopathy. Int J Cardiol. 2020 03 01; 302:124-130. PMID: 31843279; PMCID: PMC6940594.
      Citations: 10     Fields:    Translation:HumansCells
    42. Marian AJ. Role of the Extracellular Matrix in?the?Pathogenesis of Hypertrophic?Cardiomyopathy. JACC Basic Transl Sci. 2019 Aug; 4(4):506-508. PMID: 31468005; PMCID: PMC6712346.
      Citations:    
    43. Hu J, Yu J, Chen Q, Hu J, Huang Q, Xia Z, Xia Z, Ju Z, Yuan P, Fan S, Xiong Q, Zhu B, Huang L, You C, Bao H, Wu Y, Cheng X, Li J, Marian AJ, Hong K. Efficacy of Nifekalant in Patients With Wolff-Parkinson-White Syndrome and Atrial Fibrillation: Electrophysiological and Clinical Findings. J Am Heart Assoc. 2019 07 02; 8(13):e012511. PMID: 31234695; PMCID: PMC6662361.
      Citations: 2     Fields:    Translation:Humans
    44. Cheedipudi SM, Matkovich SJ, Coarfa C, Hu X, Robertson MJ, Sweet M, Taylor M, Mestroni L, Cleveland J, Willerson JT, Gurha P, Marian AJ. Genomic Reorganization of Lamin-Associated Domains in Cardiac Myocytes Is Associated With Differential Gene Expression and DNA Methylation in Human Dilated Cardiomyopathy. Circ Res. 2019 04 12; 124(8):1198-1213. PMID: 30739589; PMCID: PMC6459729.
      Citations: 34     Fields:    Translation:HumansCells
    45. Chen SN, Lombardi R, Karmouch J, Tsai JY, Czernuszewicz G, Taylor MRG, Mestroni L, Coarfa C, Gurha P, Marian AJ. DNA Damage Response/TP53 Pathway Is Activated and Contributes to the Pathogenesis of Dilated Cardiomyopathy Associated With LMNA (Lamin A/C) Mutations. Circ Res. 2019 03 15; 124(6):856-873. PMID: 30696354; PMCID: PMC6460911.
      Citations: 42     Fields:    Translation:AnimalsCells
    46. Mcginnigle E, Marian AJ. Scientists on the Spot: A brief word with Ali J. Marian on cardiovascular genetics. Cardiovasc Res. 2018 10 01; 114(12):e91-e92. PMID: 31346600; PMCID: PMC10233282.
      Citations:    Fields:    
    47. Marian AJ. Genetic Testing in Cardiovascular Medicine. Tex Heart Inst J. 2018 08; 45(4):231-232. PMID: 30374232; PMCID: PMC6183645.
      Citations:    Fields:    Translation:Humans
    48. Chamberlain K, Riyad JM, Garnett T, Kohlbrenner E, Mookerjee A, Elmastour F, Benard L, Chen J, VandenDriessche T, Chuah MK, Marian AJ, Hajjar RJ, Gurha P, Weber T. A Calsequestrin Cis-Regulatory Motif Coupled to a Cardiac Troponin T Promoter Improves Cardiac Adeno-Associated Virus Serotype 9 Transduction Specificity. Hum Gene Ther. 2018 08; 29(8):927-937. PMID: 29641321; PMCID: PMC6098410.
      Citations: 4     Fields:    Translation:HumansAnimalsCells
    49. Marian AJ, Tan Y, Li L, Chang J, Syrris P, Hessabi M, Rahbar MH, Willerson JT, Cheong BY, Liu CY, Kleiman NS, Bluemke DA, Nagueh SF. Hypertrophy Regression With N-Acetylcysteine in Hypertrophic Cardiomyopathy (HALT-HCM): A Randomized, Placebo-Controlled, Double-Blind Pilot Study. Circ Res. 2018 04 13; 122(8):1109-1118. PMID: 29540445; PMCID: PMC5899034.
      Citations: 14     Fields:    Translation:Humans
    50. Auguste G, Gurha P, Lombardi R, Coarfa C, Willerson JT, Marian AJ. Suppression of Activated FOXO Transcription Factors in the Heart Prolongs Survival in a Mouse Model of Laminopathies. Circ Res. 2018 03 02; 122(5):678-692. PMID: 29317431; PMCID: PMC5834384.
      Citations: 24     Fields:    Translation:AnimalsCells
    51. Marian AJ. Non-syndromic cardiac progeria in a patient with the rare pathogenic p.Asp300Asn variant in the LMNA gene. BMC Med Genet. 2017 10 18; 18(1):116. PMID: 29047356; PMCID: PMC5648416.
      Citations: 3     Fields:    Translation:HumansCells
    52. Karmouch J, Zhou QQ, Miyake CY, Lombardi R, Kretzschmar K, Bannier-H?laou?t M, Clevers H, Wehrens XHT, Willerson JT, Marian AJ. Distinct Cellular Basis for Early Cardiac Arrhythmias, the Cardinal Manifestation of Arrhythmogenic Cardiomyopathy, and the Skin Phenotype of Cardiocutaneous Syndromes. Circ Res. 2017 Dec 08; 121(12):1346-1359. PMID: 29018034; PMCID: PMC5722680.
      Citations: 12     Fields:    Translation:HumansAnimalsCells
    53. Marian AJ, Braunwald E. Hypertrophic Cardiomyopathy: Genetics, Pathogenesis, Clinical Manifestations, Diagnosis, and Therapy. Circ Res. 2017 Sep 15; 121(7):749-770. PMID: 28912181; PMCID: PMC5654557.
      Citations: 248     Fields:    Translation:HumansAnimals
    54. Marian AJ. New landscape of cardiovascular genetics and genomics. Curr Opin Cardiol. 2017 May; 32(3):229-231. PMID: 28240644.
      Citations:    Fields:    
    55. Marian AJ. Congenital Heart Disease: The Remarkable Journey From the "Post-Mortem Room" to Adult Clinics. Circ Res. 2017 03 17; 120(6):895-897. PMID: 28302735; PMCID: PMC5378310.
      Citations: 3     Fields:    Translation:Humans
    56. Bainbridge MN, Li L, Tan Y, Cheong BY, Marian AJ. Identification of established arrhythmogenic right ventricular cardiomyopathy mutation in a patient with the contrasting phenotype of hypertrophic cardiomyopathy. BMC Med Genet. 2017 Mar 03; 18(1):24. PMID: 28253841; PMCID: PMC5335712.
      Citations: 4     Fields:    Translation:Humans
    57. Li L, Bainbridge MN, Tan Y, Willerson JT, Marian AJ. A Potential Oligogenic Etiology of Hypertrophic Cardiomyopathy: A Classic Single-Gene Disorder. Circ Res. 2017 Mar 31; 120(7):1084-1090. PMID: 28223422; PMCID: PMC5380229.
      Citations: 17     Fields:    Translation:Humans
    58. Marian AJ, van Rooij E, Roberts R. Genetics and Genomics of Single-Gene Cardiovascular Diseases: Common Hereditary Cardiomyopathies as Prototypes of?Single-Gene Disorders. J Am Coll Cardiol. 2016 Dec 27; 68(25):2831-2849. PMID: 28007145; PMCID: PMC5189923.
      Citations: 16     Fields:    Translation:Humans
    59. Lynch TL, Kuster DWD, Gonzalez B, Balasubramanian N, Nair N, Day S, Calvino JE, Tan Y, Liebetrau C, Troidl C, Hamm CW, McDonough B, Marian AJ, van der Velden J, Seidman CE, Huggins GS, Sadayappan S, G??l? A. Cardiac Myosin Binding Protein-C Autoantibodies are Potential Early Indicators of Cardiac Dysfunction and Patient Outcome in Acute Coronary Syndrome. JACC Basic Transl Sci. 2017 Apr; 2(2):122-131. PMID: 28596995; PMCID: PMC5460768.
      Citations: 2     
    60. Marian AJ. Challenges in the Diagnosis of Anderson-Fabry Disease: A Deceptively Simple and Yet Complicated Genetic Disease. J Am Coll Cardiol. 2016 09 06; 68(10):1051-3. PMID: 27585510.
      Citations: 7     Fields:    Translation:Humans
    61. Gurha P, Chen X, Lombardi R, Willerson JT, Marian AJ. Knockdown of Plakophilin 2 Downregulates miR-184 Through CpG Hypermethylation and Suppression of the E2F1 Pathway and Leads to Enhanced Adipogenesis In Vitro. Circ Res. 2016 Sep 02; 119(6):731-50. PMID: 27470638; PMCID: PMC5010490.
      Citations: 25     Fields:    Translation:AnimalsCells
    62. Marian AJ. The Case of "Missing Causal Genes" and the Practice of Medicine: A Sherlock Holmes Approach of Deductive Reasoning. Circ Res. 2016 06 24; 119(1):21-4. PMID: 27340268; PMCID: PMC4922504.
      Citations: 10     Fields:    Translation:HumansAnimals
    63. Lombardi R, Chen SN, Ruggiero A, Gurha P, Czernuszewicz GZ, Willerson JT, Marian AJ. Cardiac Fibro-Adipocyte Progenitors Express Desmosome Proteins and Preferentially Differentiate to Adipocytes Upon Deletion of the Desmoplakin Gene. Circ Res. 2016 06 24; 119(1):41-54. PMID: 27121621; PMCID: PMC4920717.
      Citations: 46     Fields:    Translation:HumansAnimalsCells
    64. Marian AJ. Clinical applications of molecular genetic discoveries. Transl Res. 2016 Feb; 168:6-14. PMID: 26548329; PMCID: PMC4718781.
      Citations:    Fields:    Translation:HumansCells
    65. Marian AJ. The Bottleneck in Genetic Testing. Circ Res. 2015 Sep 11; 117(7):586-8. PMID: 26358106; PMCID: PMC4576699.
      Citations:    Fields:    Translation:Humans
    66. Xiong Q, Cao Q, Zhou Q, Xie J, Shen Y, Wan R, Yu J, Yan S, Marian AJ, Hong K. Arrhythmogenic cardiomyopathy in a patient with a rare loss-of-function KCNQ1 mutation. J Am Heart Assoc. 2015 Jan 23; 4(1):e001526. PMID: 25616976; PMCID: PMC4330077.
      Citations: 12     Fields:    Translation:Humans
    67. Madonna R, Ferdinandy P, De Caterina R, Willerson JT, Marian AJ. Recent developments in cardiovascular stem cells. Circ Res. 2014 Dec 05; 115(12):e71-8. PMID: 25477490.
      Citations: 14     Fields:    Translation:HumansAnimalsCells
    68. Marian AJ. Copy number variants and the genetic enigma of congenital heart disease. Circ Res. 2014 Oct 24; 115(10):821-3. PMID: 25342769; PMCID: PMC4212159.
      Citations: 4     Fields:    Translation:Humans
    69. Marian AJ. Recent developments in cardiovascular genetics and genomics. Circ Res. 2014 Sep 12; 115(7):e11-7. PMID: 25214576.
      Citations: 3     Fields:    Translation:Humans
    70. Marian AJ, Williams R. Ali J. Marian: life and science are one. Circ Res. 2014 Aug 29; 115(6):549-51. PMID: 25170092.
      Citations:    Fields:    Translation:Humans
    71. Korf BR, Berry AB, Limson M, Marian AJ, Murray MF, O'Rourke PP, Passamani ER, Relling MV, Tooker J, Tsongalis GJ, Rodriguez LL. Framework for development of physician competencies in genomic medicine: report of the Competencies Working Group of the Inter-Society Coordinating Committee for Physician Education in Genomics. Genet Med. 2014 Nov; 16(11):804-9. PMID: 24763287.
      Citations: 67     Fields:    Translation:Humans
    72. Marian AJ. Causality in genetics: the gradient of genetic effects and back to Koch's postulates of causality. Circ Res. 2014 Jan 17; 114(2):e18-21. PMID: 24436434; PMCID: PMC3896867.
      Citations: 17     Fields:    Translation:HumansAnimals
    73. Kuster DW, Cardenas-Ospina A, Miller L, Liebetrau C, Troidl C, Nef HM, Hamm CW, Pieper KS, Mahaffey KW, Kleiman NS, Stuyvers BD, Marian AJ, Sadayappan S, M?llmann H. Release kinetics of circulating cardiac myosin binding protein-C following cardiac injury. Am J Physiol Heart Circ Physiol. 2014 Feb 15; 306(4):H547-56. PMID: 24337456; PMCID: PMC3920245.
      Citations: 9     Fields:    Translation:HumansAnimals
    74. Gurha P, Marian AJ. Noncoding RNAs in cardiovascular biology and disease. Circ Res. 2013 Dec 06; 113(12):e115-20. PMID: 24311620.
      Citations: 9     Fields:    Translation:HumansAnimals
    75. Marian AJ. On the diagnostic utility of junction plakoglobin in arrhythmogenic right ventricular cardiomyopathy. Cardiovasc Pathol. 2013 Sep-Oct; 22(5):309-11. PMID: 23806441.
      Citations: 3     Fields:    Translation:HumansCells
    76. Marian AJ. Errors in DNA replication and genetic diseases. Curr Opin Cardiol. 2013 May; 28(3):269-71. PMID: 23549234.
      Citations:    Fields:    Translation:HumansCells
    77. Peng X, Shao J, Shen Y, Zhou Y, Cao Q, Hu J, He W, Yu X, Liu X, Marian AJ, Hong K. FAT10 protects cardiac myocytes against apoptosis. J Mol Cell Cardiol. 2013 Jun; 59:1-10. PMID: 23416168; PMCID: PMC3646899.
      Citations: 9     Fields:    Translation:HumansAnimalsCells
    78. Ruggiero A, Chen SN, Lombardi R, Rodriguez G, Marian AJ. Pathogenesis of hypertrophic cardiomyopathy caused by myozenin 2 mutations is independent of calcineurin activity. Cardiovasc Res. 2013 Jan 01; 97(1):44-54. PMID: 22987565; PMCID: PMC3527764.
      Citations: 24     Fields:    Translation:HumansAnimalsCells
    79. Marian AJ. Challenges in medical applications of whole exome/genome sequencing discoveries. Trends Cardiovasc Med. 2012 Nov; 22(8):219-23. PMID: 22921985; PMCID: PMC3496831.
      Citations: 15     Fields:    Translation:Humans
    80. Chen SN, Czernuszewicz G, Tan Y, Lombardi R, Jin J, Willerson JT, Marian AJ. Human molecular genetic and functional studies identify TRIM63, encoding Muscle RING Finger Protein 1, as a novel gene for human hypertrophic cardiomyopathy. Circ Res. 2012 Sep 14; 111(7):907-19. PMID: 22821932; PMCID: PMC3482312.
      Citations: 67     Fields:    Translation:HumansAnimalsCells
    81. Marian AJ. Elements of 'missing heritability'. Curr Opin Cardiol. 2012 May; 27(3):197-201. PMID: 22450721.
      Citations: 26     Fields:    Translation:Humans
    82. Marian AJ. Molecular genetic studies of complex phenotypes. Transl Res. 2012 Feb; 159(2):64-79. PMID: 22243791; PMCID: PMC3259530.
      Citations: 48     Fields:    Translation:HumansCells
    83. Marian AJ. Modeling human disease phenotype in model organisms: "It's only a model!". Circ Res. 2011 Aug 05; 109(4):356-9. PMID: 21817163; PMCID: PMC3160674.
      Citations: 10     Fields:    Translation:HumansAnimals
    84. Rodriguez G, Ueyama T, Ogata T, Czernuszewicz G, Tan Y, Dorn GW, Bogaev R, Amano K, Oh H, Matsubara H, Willerson JT, Marian AJ. Molecular genetic and functional characterization implicate muscle-restricted coiled-coil gene (MURC) as a causal gene for familial dilated cardiomyopathy. Circ Cardiovasc Genet. 2011 Aug 01; 4(4):349-58. PMID: 21642240; PMCID: PMC3157556.
      Citations: 22     Fields:    Translation:HumansAnimalsCells
    85. Marian AJ. Genome-wide association studies complemented with mechanistic biological studies identify sortilin 1 as a novel regulator of cholesterol trafficking. Curr Atheroscler Rep. 2011 Jun; 13(3):190-2. PMID: 21287300; PMCID: PMC7089479.
      Citations: 2     Fields:    
    86. Rodriguez G, Starr AZ, Czernuszewicz GZ, Manhas A, Alhariri A, Willerson JT, Reist CJ, Pieper K, Mahaffey KW, Marian AJ, Kleiman NS. Determinants of plasma vitamin D levels in patients with acute coronary syndromes. Eur J Clin Invest. 2011 Dec; 41(12):1299-309. PMID: 21615392.
      Citations: 3     Fields:    Translation:Humans
    87. Marian AJ. Medical DNA sequencing. Curr Opin Cardiol. 2011 May; 26(3):175-80. PMID: 21415728; PMCID: PMC3144864.
      Citations: 4     Fields:    Translation:HumansCells
    88. Alexander D, Lombardi R, Rodriguez G, Mitchell MM, Marian AJ. Metabolomic distinction and insights into the pathogenesis of human primary dilated cardiomyopathy. Eur J Clin Invest. 2011 May; 41(5):527-38. PMID: 21155767; PMCID: PMC3071865.
      Citations: 38     Fields:    Translation:Humans
    89. Nagueh SF, Lombardi R, Tan Y, Wang J, Willerson JT, Marian AJ. Atorvastatin and cardiac hypertrophy and function in hypertrophic cardiomyopathy: a pilot study. Eur J Clin Invest. 2010 Nov; 40(11):976-83. PMID: 20629707.
      Citations: 14     Fields:    Translation:Humans
    90. Marian AJ. PCSK9 as a therapeutic target in atherosclerosis. Curr Atheroscler Rep. 2010 May; 12(3):151-4. PMID: 20425252.
      Citations: 4     Fields:    
    91. Lombardi R, Marian AJ. Arrhythmogenic right ventricular cardiomyopathy is a disease of cardiac stem cells. Curr Opin Cardiol. 2010 May; 25(3):222-8. PMID: 20124997; PMCID: PMC2980568.
      Citations: 18     Fields:    Translation:HumansCells
    92. Marian AJ. DNA sequence variants and the practice of medicine. Curr Opin Cardiol. 2010 May; 25(3):182-5. PMID: 20224386; PMCID: PMC2941537.
      Citations: 1     Fields:    Translation:HumansCells
    93. Marian AJ. Hypertrophic cardiomyopathy: from genetics to treatment. Eur J Clin Invest. 2010 Apr; 40(4):360-9. PMID: 20503496; PMCID: PMC2903630.
      Citations: 39     Fields:    Translation:Humans
    94. Marian AJ. Update on hypertrophic cardiomyopathy. Tex Heart Inst J. 2010; 37(3):322-3. PMID: 20548812; PMCID: PMC2879188.
      Citations: 2     Fields:    Translation:Humans
    95. Marian AJ. Nature's genetic gradients and the clinical phenotype. Circ Cardiovasc Genet. 2009 Dec; 2(6):537-9. PMID: 20031631; PMCID: PMC2908306.
      Citations: 20     Fields:    Translation:HumansAnimals
    96. Marian AJ. Experimental therapies in hypertrophic cardiomyopathy. J Cardiovasc Transl Res. 2009 Dec; 2(4):483-92. PMID: 20560006; PMCID: PMC2904688.
      Citations: 16     Fields:    Translation:HumansAnimals
    97. Marian AJ. Cytochrome p-450 polymorphisms and response to clopidogrel. Curr Atheroscler Rep. 2009 May; 11(3):157-60. PMID: 19361345.
      Citations: 1     Fields:    Translation:Humans
    98. Guo DC, Papke CL, Tran-Fadulu V, Regalado ES, Avidan N, Johnson RJ, Kim DH, Pannu H, Willing MC, Sparks E, Pyeritz RE, Singh MN, Dalman RL, Grotta JC, Marian AJ, Boerwinkle EA, Frazier LQ, LeMaire SA, Coselli JS, Estrera AL, Safi HJ, Veeraraghavan S, Muzny DM, Wheeler DA, Willerson JT, Yu RK, Shete SS, Scherer SE, Raman CS, Buja LM, Milewicz DM. Mutations in smooth muscle alpha-actin (ACTA2) cause coronary artery disease, stroke, and Moyamoya disease, along with thoracic aortic disease. Am J Hum Genet. 2009 May; 84(5):617-27. PMID: 19409525; PMCID: PMC2680995.
      Citations: 170     Fields:    Translation:HumansCells
    99. Lombardi R, Dong J, Rodriguez G, Bell A, Leung TK, Schwartz RJ, Willerson JT, Brugada R, Marian AJ. Genetic fate mapping identifies second heart field progenitor cells as a source of adipocytes in arrhythmogenic right ventricular cardiomyopathy. Circ Res. 2009 May 08; 104(9):1076-84. PMID: 19359597; PMCID: PMC2767296.
      Citations: 66     Fields:    Translation:HumansAnimalsCells
    100. Lombardi R, Rodriguez G, Chen SN, Ripplinger CM, Li W, Chen J, Willerson JT, Betocchi S, Wickline SA, Efimov IR, Marian AJ. Resolution of established cardiac hypertrophy and fibrosis and prevention of systolic dysfunction in a transgenic rabbit model of human cardiomyopathy through thiol-sensitive mechanisms. Circulation. 2009 Mar 17; 119(10):1398-407. PMID: 19255346; PMCID: PMC2773801.
      Citations: 51     Fields:    Translation:HumansAnimalsCells
    101. Chen SN, Ballantyne CM, Gotto AM, Marian AJ. The 9p21 susceptibility locus for coronary artery disease and the severity of coronary atherosclerosis. BMC Cardiovasc Disord. 2009 Jan 27; 9:3. PMID: 19173706; PMCID: PMC2637231.
      Citations: 20     Fields:    Translation:HumansCellsCTClinical Trials
    102. Marian AJ. Contemporary treatment of hypertrophic cardiomyopathy. Tex Heart Inst J. 2009; 36(3):194-204. PMID: 19568388; PMCID: PMC2696493.
      Citations: 19     Fields:    Translation:Humans
    103. Marian AJ. Clinical implications of the "personal" genome. Curr Atheroscler Rep. 2008 Oct; 10(5):361-3. PMID: 18706275.
      Citations: 4     Fields:    Translation:Humans
    104. Marian AJ. Genome-wide association study of susceptibility alleles for coronary artery disease. Curr Atheroscler Rep. 2008 Jun; 10(3):183-5. PMID: 18489844.
      Citations:    Fields:    
    105. Marian AJ. Genetic determinants of cardiac hypertrophy. Curr Opin Cardiol. 2008 May; 23(3):199-205. PMID: 18382207; PMCID: PMC2767266.
      Citations: 42     Fields:    Translation:HumansCells
    106. Lombardi R, Bell A, Senthil V, Sidhu J, Noseda M, Roberts R, Marian AJ. Differential interactions of thin filament proteins in two cardiac troponin T mouse models of hypertrophic and dilated cardiomyopathies. Cardiovasc Res. 2008 Jul 01; 79(1):109-17. PMID: 18349139; PMCID: PMC2773799.
      Citations: 34     Fields:    Translation:AnimalsCells
    107. Marian AJ. Surprises of the genome and "personalized" medicine. J Am Coll Cardiol. 2008 Jan 29; 51(4):456-8. PMID: 18222356; PMCID: PMC2900860.
      Citations: 6     Fields:    Translation:Humans
    108. Ripplinger CM, Li W, Hadley J, Chen J, Rothenberg F, Lombardi R, Wickline SA, Marian AJ, Efimov IR. Enhanced transmural fiber rotation and connexin 43 heterogeneity are associated with an increased upper limit of vulnerability in a transgenic rabbit model of human hypertrophic cardiomyopathy. Circ Res. 2007 Nov 09; 101(10):1049-57. PMID: 17885214; PMCID: PMC2366809.
      Citations: 27     Fields:    Translation:AnimalsCells
    109. Marian AJ. A novel genetic risk factor for myocardial infarction. Curr Atheroscler Rep. 2007 Sep; 9(3):176-8. PMID: 18241610.
      Citations:    Fields:    
    110. Marian AJ. Clinical significance of single nucleotide polymorphisms in PCSK9. Curr Atheroscler Rep. 2007 Sep; 9(3):175-6. PMID: 18241609.
      Citations:    Fields:    
    111. Daw EW, Chen SN, Czernuszewicz G, Lombardi R, Lu Y, Ma J, Roberts R, Shete S, Marian AJ. Genome-wide mapping of modifier chromosomal loci for human hypertrophic cardiomyopathy. Hum Mol Genet. 2007 Oct 15; 16(20):2463-71. PMID: 17652099; PMCID: PMC2772866.
      Citations: 41     Fields:    Translation:HumansCells
    112. Marian AJ. Phenotypic plasticity of sarcomeric protein mutations. J Am Coll Cardiol. 2007 Jun 26; 49(25):2427-9. PMID: 17599606; PMCID: PMC2786898.
      Citations: 10     Fields:    Translation:HumansCells
    113. Osio A, Tan L, Chen SN, Lombardi R, Nagueh SF, Shete S, Roberts R, Willerson JT, Marian AJ. Myozenin 2 is a novel gene for human hypertrophic cardiomyopathy. Circ Res. 2007 Mar 30; 100(6):766-8. PMID: 17347475; PMCID: PMC2775141.
      Citations: 78     Fields:    Translation:HumansCells
    114. Garcia-Gras E, Lombardi R, Giocondo MJ, Willerson JT, Schneider MD, Khoury DS, Marian AJ. Suppression of canonical Wnt/beta-catenin signaling by nuclear plakoglobin recapitulates phenotype of arrhythmogenic right ventricular cardiomyopathy. J Clin Invest. 2006 Jul; 116(7):2012-21. PMID: 16823493; PMCID: PMC1483165.
      Citations: 242     Fields:    Translation:HumansAnimalsCells
    115. Marian AJ. Matrix metalloproteinase-I gene variants and risk of myocardial infarction. Curr Atheroscler Rep. 2006 May; 8(3):174-6. PMID: 16767840.
      Citations:    Fields:    Translation:HumansCells
    116. Marian AJ. Interleukin-18 and cardiovascular events. Curr Atheroscler Rep. 2006 May; 8(3):173-4. PMID: 16767839.
      Citations:    Fields:    Translation:Humans
    117. Marian AJ, Senthil V, Chen SN, Lombardi R. Antifibrotic effects of antioxidant N-acetylcysteine in a mouse model of human hypertrophic cardiomyopathy mutation. J Am Coll Cardiol. 2006 Feb 21; 47(4):827-34. PMID: 16487852; PMCID: PMC2772865.
      Citations: 47     Fields:    Translation:AnimalsCells
    118. Schillinger KJ, Tsai SY, Taffet GE, Reddy AK, Marian AJ, Entman ML, Oka K, Chan L, O'Malley BW. Regulatable atrial natriuretic peptide gene therapy for hypertension. Proc Natl Acad Sci U S A. 2005 Sep 27; 102(39):13789-94. PMID: 16162668; PMCID: PMC1236585.
      Citations: 22     Fields:    Translation:AnimalsCells
    119. Marian AJ. Cholesteryl ester transfer protein TaqIB polymorphism in the cholesterol and recurrent events study. Curr Atheroscler Rep. 2005 May; 7(3):178-9. PMID: 15811250.
      Citations:    Fields:    Translation:Humans
    120. Marian AJ. Pharmacogenetic study of statin therapy and cholesterol reduction. Curr Atheroscler Rep. 2005 May; 7(3):177-8. PMID: 15811249.
      Citations:    Fields:    Translation:Humans
    121. Chen SN, Ballantyne CM, Gotto AM, Tan Y, Willerson JT, Marian AJ. A common PCSK9 haplotype, encompassing the E670G coding single nucleotide polymorphism, is a novel genetic marker for plasma low-density lipoprotein cholesterol levels and severity of coronary atherosclerosis. J Am Coll Cardiol. 2005 May 17; 45(10):1611-9. PMID: 15893176; PMCID: PMC2910256.
      Citations: 55     Fields:    Translation:HumansCTClinical Trials
    122. Roberts R, Marian AJ. Can an energy-deficient heart grow bigger and stronger? J Am Coll Cardiol. 2003 May 21; 41(10):1783-5. PMID: 12767665; PMCID: PMC2910249.
      Citations: 2     Fields:    Translation:Humans
    123. Marian AJ. On predictors of sudden cardiac death in hypertrophic cardiomyopathy. J Am Coll Cardiol. 2003 Mar 19; 41(6):994-6. PMID: 12651047; PMCID: PMC2887726.
      Citations: 7     Fields:    Translation:Humans
    124. Ma K, Cilingiroglu M, Otvos JD, Ballantyne CM, Marian AJ, Chan L. Endothelial lipase is a major genetic determinant for high-density lipoprotein concentration, structure, and metabolism. Proc Natl Acad Sci U S A. 2003 Mar 04; 100(5):2748-53. PMID: 12601178; PMCID: PMC151412.
      Citations: 77     Fields:    Translation:HumansAnimalsCells
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