JIANRONGTANGJIANRONG TANG32.31117320000000-90.07681340000000617TANG, JIANRONGAssociate Professorprns:coAuthorOfcoauthor ofprns:endDateend dateFaculty Rankprns:fullNamefull nameprns:grantAwardedBygrant awarded byprns:hasAuthorListauthor listprns:hasFacultyRankhas faculty rankprns:hasNetworkhas networkprns:hasPublicationVenuepublished inprns:informationResourceReferenceinformation resource referenceprns:isPrimaryPositionis primary positionprns:latitudelatitudeprns:longitudelongitudeprns:mainImagephotoprns:maxWeightmaximum weightprns:medlineTAjournal title abbreviationprns:meshDescriptorUIMeSH DescriptorUIprns:meshSemanticGroupNameMeSH semantic group nameprns:minWeightminimum weightprns:numberOfAuthorsnumber of authorsprns:numberOfConnectionsnumber of connectionsprns:numberOfPublicationsnumber of publicationsprns:personIdPerson IDprns:personInPrimaryPositionperson in primary positionprns:physicalNeighborOfphysical neighborprns:positionInDepartmentposition in departmentprns:positionInDivisionposition in divisionprns:predicateNodepredicate nodeprns:principalInvestigatorNameprincipal investigator nameprns:publicationDatepublication dateprns:similarTosimilar toprns:sortOrdersort orderprns:startDatestart dateprns:uniquenessWeightuniqueness weightprns:yearyearAcademic ArticleArticleDocumentbibo:pmidPubMed IdentifierAddressvivo:address1address line 1vivo:addressCitycityvivo:addressPostalCodepostal codevivo:addressStatestate or provinceAgreementvivo:authorInAuthorshipselected publicationsvivo:authorRankauthor rank in publicationAuthorshipDepartmentDivisionGrantvivo:hasResearchArearesearch areasvivo:hasResearcherRoleresearch activitiesvivo:hrJobTitleHR job titleInformation Resourcevivo:linkedAuthorlinked authorvivo:linkedInformationResourcelinked information resourcevivo:mailingAddressmailing addressvivo:personInPositionpositionsPositionvivo:positionInOrganizationposition in organizationvivo:preferredTitlepreferred titleResearcher Rolevivo:researcherRoleOfresearcher role ofRolevivo:roleContributesTocontributes tovivo:sponsorAwardIdsponsor award idrdf:predicatepredicaterdf:typetyperdfs:labellabelConceptAgentfoaf:firstNamefirst namefoaf:lastNamelast nameOrganizationPerson25445492Jenson D, Yang K, Acevedo-Rodriguez A, Levine A, Broussard JI, Tang J, Dani JANeuropharmacologyDopamine and norepinephrine receptors participate in methylphenidate enhancement of in vivo hippocampal synaptic plasticity. Neuropharmacology. 2015 Mar; 90:23-32.Neuropharmacology2014-11-11T00:00:002014Dopamine and norepinephrine receptors participate in methylphenidate enhancement of in vivo hippocampal synaptic plasticity.Authorship 830045Authorship 883791Authorship 66141Authorship 906703JAMESORENGOJAMES ORENGO10700ORENGO, JAMESAssistant ProfessorAuthorship 2813727Authorship 2813736Authorship 2813741226605526Sztainberg Y, Chen HM, Swann JW, Hao S, Tang B, Wu Z, Tang J, Wan YW, Liu Z, Rigo F, Zoghbi HYNatureReversal of phenotypes in MECP2 duplication mice using genetic rescue or antisense oligonucleotides. Nature. 2015 Dec 03; 528(7580):123-6.Nature2015-11-25T00:00:002015Reversal of phenotypes in MECP2 duplication mice using genetic rescue or antisense oligonucleotides.26469053Hao S, Tang B, Wu Z, Ure K, Sun Y, Tao H, Gao Y, Patel AJ, Curry DJ, Samaco RC, Zoghbi HY, Tang JNatureForniceal deep brain stimulation rescues hippocampal memory in Rett syndrome mice. Nature. 2015 Oct 15; 526(7573):430-4.Nature2015-10-15T00:00:002015Forniceal deep brain stimulation rescues hippocampal memory in Rett syndrome mice.12152079Marsicano G, Wotjak CT, Azad SC, Bisogno T, Rammes G, Cascio MG, Hermann H, Tang J, Hofmann C, Zieglg?nsberger W, Di Marzo V, Lutz BNatureThe endogenous cannabinoid system controls extinction of aversive memories. Nature. 2002 Aug 01; 418(6897):530-4.Nature2002-08-01T00:00:002002The endogenous cannabinoid system controls extinction of aversive memories.74Professor10Assistant Professor14Associate Professor46Distinguished Emeritus Professor47Distinguished Service Professor27328325Meng X, Wang W, Lu H, He LJ, Chen W, Chao ES, Fiorotto ML, Tang B, Herrera JA, Seymour ML, Neul JL, Pereira FA, Tang J, Xue M, Zoghbi HYeLifeManipulations of MeCP2 in glutamatergic neurons highlight their contributions to Rett and other neurological disorders. Elife. 2016 06 21; 5.Elife2016-06-21T00:00:002016Manipulations of MeCP2 in glutamatergic neurons highlight their contributions to Rett and other neurological disorders.15813993Tang J, Ko S, Ding HK, Qiu CS, Calejesan AA, Zhuo MMolecular painPavlovian fear memory induced by activation in the anterior cingulate cortex. Mol Pain. 2005 Feb 09; 1:6.Mol Pain2005-02-09T00:00:002005Pavlovian fear memory induced by activation in the anterior cingulate cortex.Authorship 31708513Authorship 317086927328321Ure K, Lu H, Wang W, Ito-Ishida A, Wu Z, He LJ, Sztainberg Y, Chen W, Tang J, Zoghbi HYeLifeRestoration of Mecp2 expression in GABAergic neurons is sufficient to rescue multiple disease features in a mouse model of Rett syndrome. Elife. 2016 06 21; 5.Elife2016-06-21T00:00:002016Restoration of Mecp2 expression in GABAergic neurons is sufficient to rescue multiple disease features in a mouse model of Rett syndrome.Pediatrics-Neur NRI BioinformaticsPediatrics-Neur NRI CAIN16319310Wu LJ, Toyoda H, Zhao MG, Lee YS, Tang J, Ko SW, Jia YH, Shum FW, Zerbinatti CV, Bu G, Wei F, Xu TL, Muglia LJ, Chen ZF, Auberson YP, Kaang BK, Zhuo MThe Journal of neuroscience : the official journal of the Society for NeuroscienceUpregulation of forebrain NMDA NR2B receptors contributes to behavioral sensitization after inflammation. J Neurosci. 2005 Nov 30; 25(48):11107-16.J Neurosci2005-11-30T00:00:002005Upregulation of forebrain NMDA NR2B receptors contributes to behavioral sensitization after inflammation.27499081Lu H, Ash RT, He L, Kee SE, Wang W, Yu D, Hao S, Meng X, Ure K, Ito-Ishida A, Tang B, Sun Y, Ji D, Tang J, Arenkiel BR, Smirnakis SM, Zoghbi HYNeuronLoss and Gain of MeCP2 Cause Similar Hippocampal Circuit Dysfunction that Is Rescued by Deep Brain Stimulation in a Rett Syndrome Mouse Model. Neuron. 2016 Aug 17; 91(4):739-747.Neuron2016-08-04T00:00:002016Loss and Gain of MeCP2 Cause Similar Hippocampal Circuit Dysfunction that Is Rescued by Deep Brain Stimulation in a Rett Syndrome Mouse Model.16793875Kamprath K, Marsicano G, Tang J, Monory K, Bisogno T, Di Marzo V, Lutz B, Wotjak CTThe Journal of neuroscience : the official journal of the Society for NeuroscienceCannabinoid CB1 receptor mediates fear extinction via habituation-like processes. J Neurosci. 2006 Jun 21; 26(25):6677-86.J Neurosci2006-06-21T00:00:002006Cannabinoid CB1 receptor mediates fear extinction via habituation-like processes.12911760Tang J, Wagner S, Schachner M, Dityatev A, Wotjak CTThe European journal of neurosciencePotentiation of amygdaloid and hippocampal auditory-evoked potentials in a discriminatory fear-conditioning task in mice as a function of tone pattern and context. Eur J Neurosci. 2003 Aug; 18(3):639-50.Eur J Neurosci2003-08-01T00:00:002003Potentiation of amygdaloid and hippocampal auditory-evoked potentials in a discriminatory fear-conditioning task in mice as a function of tone pattern and context.15617772Wanisch K, Tang J, Mederer A, Wotjak CTBehavioural brain researchTrace fear conditioning depends on NMDA receptor activation and protein synthesis within the dorsal hippocampus of mice. Behav Brain Res. 2005 Feb 10; 157(1):63-9.Behav Brain Res2005-02-10T00:00:002005Trace fear conditioning depends on NMDA receptor activation and protein synthesis within the dorsal hippocampus of mice.27720485Lasagna-Reeves CA, de Haro M, Hao S, Park J, Rousseaux MW, Al-Ramahi I, Jafar-Nejad P, Vilanova-Velez L, See L, De Maio A, Nitschke L, Wu Z, Troncoso JC, Westbrook TF, Tang J, Botas J, Zoghbi HYNeuronReduction of Nuak1 Decreases Tau and Reverses Phenotypes in a Tauopathy Mouse Model. Neuron. 2016 Oct 19; 92(2):407-418.Neuron2016-10-06T00:00:002016Reduction of Nuak1 Decreases Tau and Reverses Phenotypes in a Tauopathy Mouse Model.1250 MOURSUND STREETHouston, 77030TX19755109Tang J, Dani JANeuronDopamine enables in vivo synaptic plasticity associated with the addictive drug nicotine. Neuron. 2009 Sep 10; 63(5):673-82.Neuron2009-09-10T00:00:002009Dopamine enables in vivo synaptic plasticity associated with the addictive drug nicotine.28392070Yeh SY, Huang WH, Wang W, Ward CS, Chao ES, Wu Z, Tang B, Tang J, Sun JJ, Esther van der Heijden M, Gray PA, Xue M, Ray RS, Ren D, Zoghbi HYNeuronRespiratory Network Stability and Modulatory Response to Substance P Require Nalcn. Neuron. 2017 Apr 19; 94(2):294-303.e4.Neuron2017-04-06T00:00:002017Respiratory Network Stability and Modulatory Response to Substance P Require Nalcn.Authorship 87331514Authorship 87331615Authorship 873317820445070Zhang TA, Tang J, Pidoplichko VI, Dani JAThe Journal of neuroscience : the official journal of the Society for NeuroscienceAddictive nicotine alters local circuit inhibition during the induction of in vivo hippocampal synaptic potentiation. J Neurosci. 2010 May 05; 30(18):6443-53.J Neurosci2010-05-05T00:00:002010Addictive nicotine alters local circuit inhibition during the induction of in vivo hippocampal synaptic potentiation.Authorship 87775838Authorship 8777594Authorship 877794829474920Gennarino VA, Palmer EE, McDonell LM, Wang L, Adamski CJ, Koire A, See L, Chen CA, Schaaf CP, Rosenfeld JA, Panzer JA, Moog U, Hao S, Bye A, Kirk EP, Stankiewicz P, Breman AM, McBride A, Kandula T, Dubbs HA, Macintosh R, Cardamone M, Zhu Y, Ying K, Dias KR, Cho MT, Henderson LB, Baskin B, Morris P, Tao J, Cowley MJ, Dinger ME, Roscioli T, Caluseriu O, Suchowersky O, Sachdev RK, Lichtarge O, Tang J, Boycott KM, Holder JL, Zoghbi HYCellA Mild PUM1 Mutation Is Associated with Adult-Onset Ataxia, whereas Haploinsufficiency Causes Developmental Delay and Seizures. Cell. 2018 02 22; 172(5):924-936.e11.Cell2018-02-22T00:00:002018A Mild PUM1 Mutation Is Associated with Adult-Onset Ataxia, whereas Haploinsufficiency Causes Developmental Delay and Seizures.29419414Orengo JP, van der Heijden ME, Hao S, Tang J, Orr HT, Zoghbi HYDisease models & mechanismsMotor neuron degeneration correlates with respiratory dysfunction in SCA1. Dis Model Mech. 2018 02 26; 11(2).Dis Model Mech2018-02-26T00:00:002018Motor neuron degeneration correlates with respiratory dysfunction in SCA1.29570050Pohodich AE, Yalamanchili H, Raman AT, Wan YW, Gundry M, Hao S, Jin H, Tang J, Liu Z, Zoghbi HYeLifeForniceal deep brain stimulation induces gene expression and splicing changes that promote neurogenesis and plasticity. Elife. 2018 03 23; 7.Elife2018-03-23T00:00:002018Forniceal deep brain stimulation induces gene expression and splicing changes that promote neurogenesis and plasticity.SAMEERSHETHSAMEER SHETH13895SHETH, SAMEERProfessortrue1ProfessorProfessortrue1Distinguished Service ProfessorDistinguished Service Professortrue1ProfessorProfessorD046690Procedures703510.688249Deep Brain StimulationD018891Anatomy27520.944947Dentate GyrusD015518Disorders682620.784646Rett Syndrometrue1Associate ProfessorAssociate ProfessorD006624Anatomy2719100.630698HippocampusD005239Physiology1532520.860633FearPharmacological & Pharmaceutical SciencesDepartment of NeurologyDepartment of NeuroscienceDepartment of PediatricsDepartment of NeurosurgeryNeurologyNeuroscienceNeurosurgeryPediatrics-NeurologyBaylor College of MedicineUniversity of Houston College of PharmacyMIRJANAMALETIC-SAVATICMIRJANA MALETIC-SAVATIC32.31117320000000-90.076813400000001490MALETIC-SAVATIC, MIRJANAAssociate ProfessorZHANDONGLIUZHANDONG LIU32.31117320000000-90.076813400000001841LIU, ZHANDONGAssociate ProfessorDANIELGLAZEDANIEL GLAZE29.70508570000000-95.401808700000002349GLAZE, DANIELDistinguished Emeritus ProfessorJOSEPHJANKOVICJOSEPH JANKOVIC0.000000000000000.000000000000002398JANKOVIC, JOSEPHProfessorJIMMYHOLDER JRJIMMY HOLDER JR29.70508570000000-95.401808700000004428HOLDER JR, JIMMYAssociate ProfessorKARIMALKADHIKARIM A. ALKADHI29.72602660000000-95.348164100000004613ALKADHI, KARIMProfessor2.427610.00603642213research areas2.534560.030347131coauthor of68.34754.6045560similar to1132selected publicationsHUDAZOGHBIHUDA ZOGHBI29.71010310000000-95.397396100000002830ZOGHBI, HUDADistinguished Service ProfessorANNEANDERSONANNE ANDERSON32.31117320000000-90.076813400000003414ANDERSON, ANNEProfessorJOHNSWANNJOHN SWANN32.31117320000000-90.076813400000003379SWANN, JOHNDistinguished Emeritus Professor31025938Creson TK, Rojas C, Hwaun E, Vaissiere T, Kilinc M, Jimenez-Gomez A, Holder JL, Tang J, Colgin LL, Miller CA, Rumbaugh GeLifeRe-expression of SynGAP protein in adulthood improves translatable measures of brain function and behavior. Elife. 2019 04 26; 8.Elife2019-04-26T00:00:002019Re-expression of SynGAP protein in adulthood improves translatable measures of brain function and behavior.32073399Chen W, Cai ZL, Chao ES, Chen H, Longley CM, Hao S, Chao HT, Kim JH, Messier JE, Zoghbi HY, Tang J, Swann JW, Xue MeLifeStxbp1/Munc18-1 haploinsufficiency impairs inhibition and mediates key neurological features of STXBP1 encephalopathy. Elife. 2020 02 19; 9.Elife2020-02-19T00:00:002020Stxbp1/Munc18-1 haploinsufficiency impairs inhibition and mediates key neurological features of STXBP1 encephalopathy.Authorship 98602911Authorship 9860308true1Associate ProfessorAssociate ProfessorAuthorship 9871261332319885Alcott CE, Yalamanchili HK, Ji P, van der Heijden ME, Saltzman A, Elrod N, Lin A, Leng M, Bhatt B, Hao S, Wang Q, Saliba A, Tang J, Malovannaya A, Wagner EJ, Liu Z, Zoghbi HYeLifePartial loss of CFIm25 causes learning deficits and aberrant neuronal alternative polyadenylation. Elife. 2020 04 22; 9.Elife2020-04-22T00:00:002020Partial loss of CFIm25 causes learning deficits and aberrant neuronal alternative polyadenylation.true1Assistant ProfessorAssistant Professor33658357Shao Y, Sztainberg Y, Wang Q, Bajikar SS, Trostle AJ, Wan YW, Jafar-Nejad P, Rigo F, Liu Z, Tang J, Zoghbi HYScience translational medicineAntisense oligonucleotide therapy in a humanized mouse model of MECP2 duplication syndrome. Sci Transl Med. 2021 03 03; 13(583).Sci Transl Med2021-03-03T00:00:002021Antisense oligonucleotide therapy in a humanized mouse model of MECP2 duplication syndrome.Authorship 1303637Authorship 1303646Authorship 130365324153177Han K, Holder JL, Schaaf CP, Lu H, Chen H, Kang H, Tang J, Wu Z, Hao S, Cheung SW, Yu P, Sun H, Breman AM, Patel A, Lu HC, Zoghbi HYNatureSHANK3 overexpression causes manic-like behaviour with unique pharmacogenetic properties. Nature. 2013 Nov 07; 503(7474):72-7.Nature2013-10-23T00:00:002013SHANK3 overexpression causes manic-like behaviour with unique pharmacogenetic properties.11701135Tang J, Wotjak CT, Wagner S, Williams G, Schachner M, Dityatev ABrain researchPotentiated amygdaloid auditory-evoked potentials and freezing behavior after fear conditioning in mice. Brain Res. 2001 Nov 23; 919(2):232-41.Brain Res2001-11-23T00:00:002001Potentiated amygdaloid auditory-evoked potentials and freezing behavior after fear conditioning in mice.12968002Wei F, Xia XM, Tang J, Ao H, Ko S, Liauw J, Qiu CS, Zhuo MThe Journal of neuroscience : the official journal of the Society for NeuroscienceCalmodulin regulates synaptic plasticity in the anterior cingulate cortex and behavioral responses: a microelectroporation study in adult rodents. J Neurosci. 2003 Sep 10; 23(23):8402-9.J Neurosci2003-09-10T00:00:002003Calmodulin regulates synaptic plasticity in the anterior cingulate cortex and behavioral responses: a microelectroporation study in adult rodents.Authorship 102316510Authorship 10375886Authorship 10375893Authorship 10378453Authorship 1037846634544833Hao S, Wang Q, Tang B, Wu Z, Yang T, Tang JThe Journal of neuroscience : the official journal of the Society for NeuroscienceCDKL5 Deficiency Augments Inhibitory Input into the Dentate Gyrus That Can Be Reversed by Deep Brain Stimulation. J Neurosci. 2021 10 27; 41(43):9031-9046.J Neurosci2021-09-20T00:00:002021CDKL5 Deficiency Augments Inhibitory Input into the Dentate Gyrus That Can Be Reversed by Deep Brain Stimulation.35005636Wang Q, Tang B, Tang JSTAR protocolsProtocol for deep brain stimulation in the fimbria-fornix of freely moving mice. STAR Protoc. 2022 03 18; 3(1):101054.STAR Protoc2021-12-21T00:00:002021Protocol for deep brain stimulation in the fimbria-fornix of freely moving mice.35310070Wang Q, de Prisco N, Tang J, Gennarino VASTAR protocolsProtocol for recording epileptiform discharges of EEG and behavioral seizures in freely moving mice. STAR Protoc. 2022 06 17; 3(2):101245.STAR Protoc2022-03-14T00:00:002022Protocol for recording epileptiform discharges of EEG and behavioral seizures in freely moving mice.35290792He L, Caudill MS, Jing J, Wang W, Sun Y, Tang J, Jiang X, Zoghbi HYNeuronA weakened recurrent circuit in the hippocampus of Rett syndrome mice disrupts long-term memory representations. Neuron. 2022 05 18; 110(10):1689-1699.e6.Neuron2022-03-14T00:00:002022A weakened recurrent circuit in the hippocampus of Rett syndrome mice disrupts long-term memory representations.true1ProfessorProfessortrue1Associate ProfessorAssociate Professortrue1ProfessorProfessortrue1Associate ProfessorAssociate Professortrue1Associate ProfessorAssociate Professortrue1Distinguished Emeritus ProfessorDistinguished Emeritus Professortrue1Distinguished Emeritus ProfessorDistinguished Emeritus Professor37890975Zhou J, Cattoglio C, Shao Y, Tirumala HP, Vetralla C, Bajikar SS, Li Y, Chen H, Wang Q, Wu Z, Tang B, Zahabiyon M, Bajic A, Meng X, Ferrie JJ, LaGrone A, Zhang P, Kim JJ, Tang J, Liu Z, Darzacq X, Heintz N, Tjian R, Zoghbi HYGenes & developmentA novel pathogenic mutation of MeCP2 impairs chromatin association independent of protein levels. Genes Dev. 2023 10 01; 37(19-20):883-900.Genes Dev2023-10-01T00:00:002023A novel pathogenic mutation of MeCP2 impairs chromatin association independent of protein levels.Authorship 10834496Authorship 108345019Principal InvestigatorPrincipal Investigator2027-07-31NIHTANG, JIANRONG2018-04-01Deep brain stimulation in Rett syndrome mice: cognitive effects and their mechanismsR01NS1007382018-03-31NIHTANG, JIANRONG2017-04-01Deep brain stimulation in Rett syndrome mice: cognitive benefits and their mechanismsR56NS10073837704033Wang Q, Tang B, Hao S, Wu Z, Yang T, Tang JBrain stimulationForniceal deep brain stimulation in a mouse model of Rett syndrome increases neurogenesis and hippocampal memory beyond the treatment period. Brain Stimul. 2023 Sep-Oct; 16(5):1401-1411.Brain Stimul2023-09-11T00:00:002023Forniceal deep brain stimulation in a mouse model of Rett syndrome increases neurogenesis and hippocampal memory beyond the treatment period.Authorship 241615Pediatrics-GeneticsMINGSHANXUEMINGSHAN XUE7735XUE, MINGSHANAssociate ProfessorAuthorship 804028Authorship 636892Authorship 729801