THOMAS WESTBROOK to Humans
This is a "connection" page, showing publications THOMAS WESTBROOK has written about Humans.
Connection Strength
0.236
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MYC Induces Oncogenic Stress through RNA Decay and Ribonucleotide Catabolism in Breast Cancer. Cancer Discov. 2024 Sep 04; 14(9):1699-1716.
Score: 0.024
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Combinatorial inhibition of PTPN12-regulated receptors leads to a broadly effective therapeutic strategy in triple-negative breast cancer. Nat Med. 2018 05; 24(4):505-511.
Score: 0.015
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The oncogenic STP axis promotes triple-negative breast cancer via degradation of the REST tumor suppressor. Cell Rep. 2014 Nov 20; 9(4):1318-32.
Score: 0.012
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A SUMOylation-dependent transcriptional subprogram is required for Myc-driven tumorigenesis. Science. 2012 Jan 20; 335(6066):348-53.
Score: 0.010
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Activation of multiple proto-oncogenic tyrosine kinases in breast cancer via loss of the PTPN12 phosphatase. Cell. 2011 Mar 04; 144(5):703-18.
Score: 0.009
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SCFbeta-TRCP controls oncogenic transformation and neural differentiation through REST degradation. Nature. 2008 Mar 20; 452(7185):370-4.
Score: 0.008
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A genetic screen for candidate tumor suppressors identifies REST. Cell. 2005 Jun 17; 121(6):837-48.
Score: 0.006
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An in vivo screen identifies NAT10 as a master regulator of brain metastasis. Sci Adv. 2025 Mar 28; 11(13):eads6021.
Score: 0.006
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Dissecting cancer pathways and vulnerabilities with RNAi. Cold Spring Harb Symp Quant Biol. 2005; 70:435-44.
Score: 0.006
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Plasma protein-based and polygenic risk scores serve complementary roles in predicting inflammatory bowel disease. Pac Symp Biocomput. 2025; 30:522-534.
Score: 0.006
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IRE1a silences dsRNA to prevent taxane-induced pyroptosis in triple-negative breast cancer. Cell. 2024 Dec 12; 187(25):7248-7266.e34.
Score: 0.006
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DNMT3A-coordinated splicing governs the stem state switch towards differentiation in embryonic and haematopoietic stem cells. Nat Cell Biol. 2023 04; 25(4):528-539.
Score: 0.005
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E7 abolishes raf-induced arrest via mislocalization of p21(Cip1). Mol Cell Biol. 2002 Oct; 22(20):7041-52.
Score: 0.005
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Human WDR5 promotes breast cancer growth and metastasis via KMT2-independent translation regulation. Elife. 2022 08 31; 11.
Score: 0.005
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Tumor suppressor PLK2 may serve as a biomarker in triple-negative breast cancer for improved response to PLK1 therapeutics. Cancer Res Commun. 2021 12; 1(3):178-193.
Score: 0.005
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Inhibition of YTHDF2 triggers proteotoxic cell death in MYC-driven breast cancer. Mol Cell. 2021 08 05; 81(15):3048-3064.e9.
Score: 0.005
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Spliceosome-targeted therapies trigger an antiviral immune response in triple-negative breast cancer. Cell. 2021 01 21; 184(2):384-403.e21.
Score: 0.005
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Proteogenomic Landscape of Breast Cancer Tumorigenesis and Targeted Therapy. Cell. 2020 11 25; 183(5):1436-1456.e31.
Score: 0.005
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Tumor progression and chromatin landscape of lung cancer are regulated by the lineage factor GATA6. Oncogene. 2020 04; 39(18):3726-3737.
Score: 0.004
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Energy-stress-mediated AMPK activation inhibits ferroptosis. Nat Cell Biol. 2020 02; 22(2):225-234.
Score: 0.004
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Reduction of Global H3K27me3 Enhances HER2/ErbB2 Targeted Therapy. Cell Rep. 2019 10 08; 29(2):249-257.e8.
Score: 0.004
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Trisomy of a Down Syndrome Critical Region Globally Amplifies Transcription via HMGN1 Overexpression. Cell Rep. 2018 11 13; 25(7):1898-1911.e5.
Score: 0.004
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A Druggable Genome Screen Identifies Modifiers of a-Synuclein Levels via a Tiered Cross-Species Validation Approach. J Neurosci. 2018 10 24; 38(43):9286-9301.
Score: 0.004
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Metabolic enzyme PFKFB4 activates transcriptional coactivator SRC-3 to drive breast cancer. Nature. 2018 04; 556(7700):249-254.
Score: 0.004
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Profound Tissue Specificity in Proliferation Control Underlies Cancer Drivers and Aneuploidy Patterns. Cell. 2018 04 05; 173(2):499-514.e23.
Score: 0.004
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Enhancer invasion shapes MYCN-dependent transcriptional amplification in neuroblastoma. Nat Genet. 2018 04; 50(4):515-523.
Score: 0.004
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A Pan-Cancer Proteogenomic Atlas of PI3K/AKT/mTOR Pathway Alterations. Cancer Cell. 2017 06 12; 31(6):820-832.e3.
Score: 0.004
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TRIM28 regulates the nuclear accumulation and toxicity of both alpha-synuclein and tau. Elife. 2016 10 25; 5.
Score: 0.003
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Reduction of Nuak1 Decreases Tau and Reverses Phenotypes in a Tauopathy Mouse Model. Neuron. 2016 Oct 19; 92(2):407-418.
Score: 0.003
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Oncogenic mTOR signalling recruits myeloid-derived suppressor cells to promote tumour initiation. Nat Cell Biol. 2016 06; 18(6):632-44.
Score: 0.003
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Mutations in the transcriptional repressor REST predispose to Wilms tumor. Nat Genet. 2015 Dec; 47(12):1471-4.
Score: 0.003
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The spliceosome is a therapeutic vulnerability in MYC-driven cancer. Nature. 2015 Sep 17; 525(7569):384-8.
Score: 0.003
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A Systematic Analysis of Factors Localized to Damaged Chromatin Reveals PARP-Dependent Recruitment of Transcription Factors. Cell Rep. 2015 Jun 09; 11(9):1486-500.
Score: 0.003
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Elevated CDCP1 predicts poor patient outcome and mediates ovarian clear cell carcinoma by promoting tumor spheroid formation, cell migration and chemoresistance. Oncogene. 2016 Jan 28; 35(4):468-78.
Score: 0.003
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The osteogenic niche promotes early-stage bone colonization of disseminated breast cancer cells. Cancer Cell. 2015 Feb 09; 27(2):193-210.
Score: 0.003
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Overcoming endocrine resistance due to reduced PTEN levels in estrogen receptor-positive breast cancer by co-targeting mammalian target of rapamycin, protein kinase B, or mitogen-activated protein kinase kinase. Breast Cancer Res. 2014 Sep 11; 16(5):430.
Score: 0.003
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MYC-driven accumulation of 2-hydroxyglutarate is associated with breast cancer prognosis. J Clin Invest. 2014 Jan; 124(1):398-412.
Score: 0.003
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RAS-MAPK-MSK1 pathway modulates ataxin 1 protein levels and toxicity in SCA1. Nature. 2013 Jun 20; 498(7454):325-331.
Score: 0.003
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Control of alveolar differentiation by the lineage transcription factors GATA6 and HOPX inhibits lung adenocarcinoma metastasis. Cancer Cell. 2013 Jun 10; 23(6):725-38.
Score: 0.003
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A role for PVRL4-driven cell-cell interactions in tumorigenesis. Elife. 2013 Apr 30; 2:e00358.
Score: 0.003
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Selective small molecule Stat3 inhibitor reduces breast cancer tumor-initiating cells and improves recurrence free survival in a human-xenograft model. PLoS One. 2012; 7(8):e30207.
Score: 0.003
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The pINDUCER lentiviral toolkit for inducible RNA interference in vitro and in vivo. Proc Natl Acad Sci U S A. 2011 Mar 01; 108(9):3665-70.
Score: 0.002
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A genome-wide RNAi screen identifies multiple synthetic lethal interactions with the Ras oncogene. Cell. 2009 May 29; 137(5):835-48.
Score: 0.002
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CDYL bridges REST and histone methyltransferases for gene repression and suppression of cellular transformation. Mol Cell. 2008 Dec 05; 32(5):718-26.
Score: 0.002
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Cancer proliferation gene discovery through functional genomics. Science. 2008 Feb 01; 319(5863):620-4.
Score: 0.002
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A resource for large-scale RNA-interference-based screens in mammals. Nature. 2004 Mar 25; 428(6981):427-31.
Score: 0.001
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Human papillomavirus type 16 E7 maintains elevated levels of the cdc25A tyrosine phosphatase during deregulation of cell cycle arrest. J Virol. 2002 Jan; 76(2):619-32.
Score: 0.001
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Biology of human papillomaviruses. Int J Exp Pathol. 2001 Feb; 82(1):15-33.
Score: 0.001