YILIYI LI0.000000000000000.00000000000000520LI, YIbreast cancer, prevention, cancer stem cell, cancer genetics, mouse model, Wnt, LGR4, STAT5, ErbB2, diabetes, pregnancy, lactationProfessorprns:coAuthorOfcoauthor ofprns:emailEncryptedemail addressprns:endDateend dateFaculty Rankprns:fullNamefull nameprns:grantAwardedBygrant awarded byprns:hasAuthorListauthor listprns:hasFacultyRankhas faculty rankprns:hasNetworkhas networkprns:hasPublicationVenuepublished inprns:informationResourceReferenceinformation resource referenceprns:isPrimaryPositionis primary positionprns:latitudelatitudeprns:longitudelongitudeprns:mainImagephotoprns:maxWeightmaximum weightprns:medlineTAjournal title abbreviationprns:meshDescriptorUIMeSH DescriptorUIprns:meshSemanticGroupNameMeSH semantic group nameprns:minWeightminimum weightprns:numberOfAuthorsnumber of authorsprns:numberOfConnectionsnumber of connectionsprns:numberOfPublicationsnumber of publicationsprns:personIdPerson IDprns:personInPrimaryPositionperson in primary positionprns:physicalNeighborOfphysical neighborprns:positionInDepartmentposition in departmentprns:positionInDivisionposition in divisionprns:predicateNodepredicate nodeprns:principalInvestigatorNameprincipal investigator nameprns:publicationDatepublication dateprns:similarTosimilar toprns:sortOrdersort orderprns:startDatestart dateprns:uniquenessWeightuniqueness weightprns:yearyearAcademic ArticleArticleDocumentbibo:pmidPubMed IdentifierAddressAgreementvivo:authorInAuthorshipselected publicationsvivo:authorRankauthor rank in publicationAuthorshipDepartmentDivisionvivo:freetextKeywordkeywordsGrantvivo:hasResearchArearesearch areasvivo:hasResearcherRoleresearch activitiesvivo:hrJobTitleHR job titleInformation Resourcevivo:linkAnchorTextlink anchor textvivo:linkedAuthorlinked authorvivo:linkedInformationResourcelinked information resourcevivo:mailingAddressmailing addressvivo:personInPositionpositionsPositionvivo:positionInOrganizationposition in organizationvivo:preferredTitlepreferred titleResearcher Rolevivo:researcherRoleOfresearcher role ofRolevivo:roleContributesTocontributes tovivo:sponsorAwardIdsponsor award idURLLinkvivo:webpagewebpagerdf:predicatepredicaterdf:typetyperdfs:labellabelConceptAgentfoaf:firstNamefirst namefoaf:lastNamelast nameOrganizationPersonAuthorship 9181915Authorship 108256123541951Haricharan S, Li YMolecular and cellular endocrinologySTAT signaling in mammary gland differentiation, cell survival and tumorigenesis. Mol Cell Endocrinol. 2014 Jan 25; 382(1):560-569.Mol Cell Endocrinol2013-03-28T00:00:002013STAT signaling in mammary gland differentiation, cell survival and tumorigenesis.25635772Holloway KR, Sinha VC, Toneff MJ, Bu W, Hilsenbeck SG, Li YPloS oneKrt6a-positive mammary epithelial progenitors are not at increased vulnerability to tumorigenesis initiated by ErbB2. PLoS One. 2015; 10(1):e0117239.PLoS One2015-01-30T00:00:002015Krt6a-positive mammary epithelial progenitors are not at increased vulnerability to tumorigenesis initiated by ErbB2.Authorship 2642413Authorship 277103Breast Medical OncologyMolecular & Cellular OncologySystems BiologyMD AndersonMIEN-CHIEHUNGMIEN-CHIE HUNG8427HUNG, MIEN-CHIEProfessorNAOTO TUENONAOTO T UENO8465UENO, NAOTO TProfessorGORDON BMILLSGORDON B MILLS8620MILLS, GORDON BProfessor7565703Li Y, Dodgson JBMolecular and cellular biologyThe chicken HMG-17 gene is dispensable for cell growth in vitro. Mol Cell Biol. 1995 Oct; 15(10):5516-23.Mol Cell Biol1995-10-01T00:00:001995The chicken HMG-17 gene is dispensable for cell growth in vitro.9792699Li Y, Smith T, Grabski S, DeWitt DLThe Journal of biological chemistryThe membrane association sequences of the prostaglandin endoperoxide synthases-1 and -2 isozymes. J Biol Chem. 1998 Nov 06; 273(45):29830-7.J Biol Chem1998-11-06T00:00:001998The membrane association sequences of the prostaglandin endoperoxide synthases-1 and -2 isozymes.26287601Qin L, Xu Y, Xu Y, Ma G, Liao L, Wu Y, Li Y, Wang X, Wang X, Jiang J, Wang J, Xu JOncotargetNCOA1 promotes angiogenesis in breast tumors by simultaneously enhancing both HIF1a- and AP-1-mediated VEGFa transcription. Oncotarget. 2015 Sep 15; 6(27):23890-904.Oncotarget2015-09-15T00:00:002015NCOA1 promotes angiogenesis in breast tumors by simultaneously enhancing both HIF1a- and AP-1-mediated VEGFa transcription.26146825Shi A, Dong J, Hilsenbeck S, Bi L, Zhang H, Li YPloS oneThe Status of STAT3 and STAT5 in Human Breast Atypical Ductal Hyperplasia. PLoS One. 2015; 10(7):e0132214.PLoS One2015-07-06T00:00:002015The Status of STAT3 and STAT5 in Human Breast Atypical Ductal Hyperplasia.26166574Zheng ZY, Tian L, Bu W, Fan C, Gao X, Wang H, Liao YH, Li Y, Lewis MT, Edwards D, Zwaka TP, Hilsenbeck SG, Medina D, Perou CM, Creighton CJ, Zhang XH, Chang ECCell reportsWild-Type N-Ras, Overexpressed in Basal-like Breast Cancer, Promotes Tumor Formation by Inducing IL-8 Secretion via JAK2 Activation. Cell Rep. 2015 Jul 21; 12(3):511-24.Cell Rep2015-07-09T00:00:002015Wild-Type N-Ras, Overexpressed in Basal-like Breast Cancer, Promotes Tumor Formation by Inducing IL-8 Secretion via JAK2 Activation.26589974Fang X, Wei J, He X, An P, Wang H, Jiang L, Shao D, Liang H, Li Y, Wang F, Min JEuropean journal of cancer (Oxford, England : 1990)Landscape of dietary factors associated with risk of gastric cancer: A systematic review and dose-response meta-analysis of prospective cohort studies. Eur J Cancer. 2015 Dec; 51(18):2820-32.Eur J Cancer2015-11-14T00:00:002015Landscape of dietary factors associated with risk of gastric cancer: A systematic review and dose-response meta-analysis of prospective cohort studies.10980141Holland EC, Li Y, Celestino J, Dai C, Schaefer L, Sawaya RA, Fuller GNThe American journal of pathologyAstrocytes give rise to oligodendrogliomas and astrocytomas after gene transfer of polyoma virus middle T antigen in vivo. Am J Pathol. 2000 Sep; 157(3):1031-7.Am J Pathol2000-09-01T00:00:002000Astrocytes give rise to oligodendrogliomas and astrocytomas after gene transfer of polyoma virus middle T antigen in vivo.11416866Dunn KJ, Incao A, Watkins-Chow D, Li Y, Pavan WJGenesis (New York, N.Y. : 2000)In utero complementation of a neural crest-derived melanocyte defect using cell directed gene transfer. Genesis. 2001 Jun; 30(2):70-6.Genesis2001-06-01T00:00:002001In utero complementation of a neural crest-derived melanocyte defect using cell directed gene transfer.9016555Li Y, Strahler JR, Dodgson JBNucleic acids researchNeither HMG-14a nor HMG-17 gene function is required for growth of chicken DT40 cells or maintenance of DNaseI-hypersensitive sites. Nucleic Acids Res. 1997 Jan 15; 25(2):283-8.Nucleic Acids Res1997-01-15T00:00:001997Neither HMG-14a nor HMG-17 gene function is required for growth of chicken DT40 cells or maintenance of DNaseI-hypersensitive sites.1310754Yanagida N, Ogawa R, Li Y, Lee LF, Nazerian KJournal of virologyRecombinant fowlpox viruses expressing the glycoprotein B homolog and the pp38 gene of Marek's disease virus. J Virol. 1992 Mar; 66(3):1402-8.J Virol1992-03-01T00:00:001992Recombinant fowlpox viruses expressing the glycoprotein B homolog and the pp38 gene of Marek's disease virus.Authorship 31538414Authorship 31538512Authorship 3153863Authorship 3153876Authorship 3153887Authorship 3153898Authorship 3153906Authorship 31539111Authorship 3153929Authorship 3153937Authorship 3153948Authorship 3153958Authorship 3153966Authorship 315397225379019Doscas ME, Williamson AJ, Usha L, Bogachkov Y, Rao GS, Xiao F, Wang Y, Ruby C, Kaufman H, Zhou J, Williams JW, Li Y, Xu XNeoplasia (New York, N.Y.)Inhibition of p70 S6 kinase (S6K1) activity by A77 1726 and its effect on cell proliferation and cell cycle progress. Neoplasia. 2014 Oct; 16(10):824-34.Neoplasia2014-10-23T00:00:002014Inhibition of p70 S6 kinase (S6K1) activity by A77 1726 and its effect on cell proliferation and cell cycle progress.25253740Sinha VC, Qin L, Li YMolecular cancer research : MCRA p53/ARF-dependent anticancer barrier activates senescence and blocks tumorigenesis without impacting apoptosis. Mol Cancer Res. 2015 Feb; 13(2):231-8.Mol Cancer Res2014-09-24T00:00:002014A p53/ARF-dependent anticancer barrier activates senescence and blocks tumorigenesis without impacting apoptosis.26296387Ge GZ, Xia HJ, He BL, Zhang HL, Liu WJ, Shao M, Wang CY, Xiao J, Ge F, Li FB, Li Y, Chen CInternational journal of cancerGeneration and characterization of a breast carcinoma model by PyMT overexpression in mammary epithelial cells of tree shrew, an animal close to primates in evolution. Int J Cancer. 2016 Feb 01; 138(3):642-51.Int J Cancer2015-08-31T00:00:002015Generation and characterization of a breast carcinoma model by PyMT overexpression in mammary epithelial cells of tree shrew, an animal close to primates in evolution.26640140Dong J, Zhao W, Shi A, Toneff M, Lydon J, So D, Li YOncogeneThe PR status of the originating cell of ER/PR-negative mouse mammary tumors. Oncogene. 2016 08 04; 35(31):4149-54.Oncogene2015-12-07T00:00:002015The PR status of the originating cell of ER/PR-negative mouse mammary tumors.26096929Hein SM, Haricharan S, Johnston AN, Toneff MJ, Reddy JP, Dong J, Bu W, Li YOncogeneLuminal epithelial cells within the mammary gland can produce basal cells upon oncogenic stress. Oncogene. 2016 Mar 17; 35(11):1461-7.Oncogene2015-06-22T00:00:002015Luminal epithelial cells within the mammary gland can produce basal cells upon oncogenic stress.26785948Choi S, Chen Z, Tang LH, Fang Y, Shin SJ, Panarelli NC, Chen YT, Li Y, Jiang X, Du YNNature communicationsBcl-xL promotes metastasis independent of its anti-apoptotic activity. Nat Commun. 2016 Jan 20; 7:10384.Nat Commun2016-01-20T00:00:002016Bcl-xL promotes metastasis independent of its anti-apoptotic activity.26859575Williamson AJ, Doscas ME, Ye J, Heiden KB, Xing M, Li Y, Prinz RA, Xu XOncotargetThe sonic hedgehog signaling pathway stimulates anaplastic thyroid cancer cell motility and invasiveness by activating Akt and c-Met. Oncotarget. 2016 Mar 01; 7(9):10472-85.Oncotarget2016-03-01T00:00:002016The sonic hedgehog signaling pathway stimulates anaplastic thyroid cancer cell motility and invasiveness by activating Akt and c-Met.10963668Dunn KJ, Williams BO, Li Y, Pavan WJProceedings of the National Academy of Sciences of the United States of AmericaNeural crest-directed gene transfer demonstrates Wnt1 role in melanocyte expansion and differentiation during mouse development. Proc Natl Acad Sci U S A. 2000 Aug 29; 97(18):10050-5.Proc Natl Acad Sci U S A2000-08-29T00:00:002000Neural crest-directed gene transfer demonstrates Wnt1 role in melanocyte expansion and differentiation during mouse development.74Professor10Assistant Professor38Dean Emeritus6Adjunct Professor47Distinguished Service Professor12086888Orsulic S, Li Y, Soslow RA, Vitale-Cross LA, Gutkind JS, Varmus HECancer cellInduction of ovarian cancer by defined multiple genetic changes in a mouse model system. Cancer Cell. 2002 Feb; 1(1):53-62.Cancer Cell2002-02-01T00:00:002002Induction of ovarian cancer by defined multiple genetic changes in a mouse model system.16973609Lindvall C, Evans NC, Zylstra CR, Li Y, Alexander CM, Williams BOThe Journal of biological chemistryThe Wnt signaling receptor Lrp5 is required for mammary ductal stem cell activity and Wnt1-induced tumorigenesis. J Biol Chem. 2006 Nov 17; 281(46):35081-7.J Biol Chem2006-09-13T00:00:002006The Wnt signaling receptor Lrp5 is required for mammary ductal stem cell activity and Wnt1-induced tumorigenesis.15047889Sodhi A, Montaner S, Patel V, G?mez-Rom?n JJ, Li Y, Sausville EA, Sawai ET, Gutkind JSProceedings of the National Academy of Sciences of the United States of AmericaAkt plays a central role in sarcomagenesis induced by Kaposi's sarcoma herpesvirus-encoded G protein-coupled receptor. Proc Natl Acad Sci U S A. 2004 Apr 06; 101(14):4821-6.Proc Natl Acad Sci U S A2004-03-26T00:00:002004Akt plays a central role in sarcomagenesis induced by Kaposi's sarcoma herpesvirus-encoded G protein-coupled receptor.15824740Zhang X, Podsypanina K, Huang S, Mohsin SK, Chamness GC, Hatsell S, Cowin P, Schiff R, Li YOncogeneEstrogen receptor positivity in mammary tumors of Wnt-1 transgenic mice is influenced by collaborating oncogenic mutations. Oncogene. 2005 Jun 16; 24(26):4220-31.Oncogene2005-06-16T00:00:002005Estrogen receptor positivity in mammary tumors of Wnt-1 transgenic mice is influenced by collaborating oncogenic mutations.17121432Huang S, Podsypanina K, Chen Y, Cai W, Tsimelzon A, Hilsenbeck S, Li YTechnology in cancer research & treatmentWnt-1 is dominant over neu in specifying mammary tumor expression profiles. Technol Cancer Res Treat. 2006 Dec; 5(6):565-71.Technol Cancer Res Treat2006-12-01T00:00:002006Wnt-1 is dominant over neu in specifying mammary tumor expression profiles.18592025Siwko SK, Bu W, Gutierrez C, Lewis B, Jechlinger M, Schaffhausen B, Li YNeoplasia (New York, N.Y.)Lentivirus-mediated oncogene introduction into mammary cells in vivo induces tumors. Neoplasia. 2008 Jul; 10(7):653-62, 1 p following 662.Neoplasia2008-07-01T00:00:002008Lentivirus-mediated oncogene introduction into mammary cells in vivo induces tumors.18787212Siwko SK, Dong J, Lewis MT, Liu H, Hilsenbeck SG, Li YStem cells (Dayton, Ohio)Evidence that an early pregnancy causes a persistent decrease in the number of functional mammary epithelial stem cells--implications for pregnancy-induced protection against breast cancer. Stem Cells. 2008 Dec; 26(12):3205-9.Stem Cells2008-09-11T00:00:002008Evidence that an early pregnancy causes a persistent decrease in the number of functional mammary epithelial stem cells--implications for pregnancy-induced protection against breast cancer.19267898Kaipparettu BA, Dobrzycka KM, Britton O, Lee AV, Herron AJ, Li Y, Lewis MT, Medina D, Oesterreich SMolecular cancerScaffold Attachment Factor B1 (SAFB1) heterozygosity does not influence Wnt-1 or DMBA-induced tumorigenesis. Mol Cancer. 2009 Mar 06; 8:15.Mol Cancer2009-03-06T00:00:002009Scaffold Attachment Factor B1 (SAFB1) heterozygosity does not influence Wnt-1 or DMBA-induced tumorigenesis.Authorship 100705520217215Carpin LB, Bickford LR, Agollah G, Yu TK, Schiff R, Li Y, Drezek RABreast cancer research and treatmentImmunoconjugated gold nanoshell-mediated photothermal ablation of trastuzumab-resistant breast cancer cells. Breast Cancer Res Treat. 2011 Jan; 125(1):27-34.Breast Cancer Res Treat2010-03-10T00:00:002010Immunoconjugated gold nanoshell-mediated photothermal ablation of trastuzumab-resistant breast cancer cells.20691178Dong J, Tong T, Reynado AM, Rosen JM, Huang S, Li YDevelopmental biologyGenetic manipulation of individual somatic mammary cells in vivo reveals a master role of STAT5a in inducing alveolar fate commitment and lactogenesis even in the absence of ovarian hormones. Dev Biol. 2010 Oct 15; 346(2):196-203.Dev Biol2010-08-04T00:00:002010Genetic manipulation of individual somatic mammary cells in vivo reveals a master role of STAT5a in inducing alveolar fate commitment and lactogenesis even in the absence of ovarian hormones.22698404Jackson JG, Pant V, Li Q, Chang LL, Quint?s-Cardama A, Garza D, Tavana O, Yang P, Manshouri T, Li Y, El-Naggar AK, Lozano GCancer cellp53-mediated senescence impairs the apoptotic response to chemotherapy and clinical outcome in breast cancer. Cancer Cell. 2012 Jun 12; 21(6):793-806.Cancer Cell2012-06-12T00:00:002012p53-mediated senescence impairs the apoptotic response to chemotherapy and clinical outcome in breast cancer.21532625Bu W, Chen J, Morrison GD, Huang S, Creighton CJ, Huang J, Chamness GC, Hilsenbeck SG, Roop DR, Leavitt AD, Li YOncogeneKeratin 6a marks mammary bipotential progenitor cells that can give rise to a unique tumor model resembling human normal-like breast cancer. Oncogene. 2011 Oct 27; 30(43):4399-409.Oncogene2011-05-02T00:00:002011Keratin 6a marks mammary bipotential progenitor cells that can give rise to a unique tumor model resembling human normal-like breast cancer.21846369Zhu M, Yi M, Kim CH, Deng C, Li Y, Medina D, Stephens RM, Green JEGenome biologyIntegrated miRNA and mRNA expression profiling of mouse mammary tumor models identifies miRNA signatures associated with mammary tumor lineage. Genome Biol. 2011 Aug 16; 12(8):R77.Genome Biol2011-08-16T00:00:002011Integrated miRNA and mRNA expression profiling of mouse mammary tumor models identifies miRNA signatures associated with mammary tumor lineage.22069192Dong J, Huang S, Caikovski M, Ji S, McGrath A, Custorio MG, Creighton CJ, Maliakkal P, Bogoslovskaia E, Du Z, Zhang X, Lewis MT, Sablitzky F, Brisken C, Li YDevelopment (Cambridge, England)ID4 regulates mammary gland development by suppressing p38MAPK activity. Development. 2011 Dec; 138(23):5247-56.Development2011-12-01T00:00:002011ID4 regulates mammary gland development by suppressing p38MAPK activity.11178110Li Y, Podsypanina K, Liu X, Crane A, Tan LK, Parsons R, Varmus HEBMC molecular biologyDeficiency of Pten accelerates mammary oncogenesis in MMTV-Wnt-1 transgenic mice. BMC Mol Biol. 2001; 2:2.BMC Mol Biol2001-01-23T00:00:002001Deficiency of Pten accelerates mammary oncogenesis in MMTV-Wnt-1 transgenic mice.12559173Montaner S, Sodhi A, Molinolo A, Bugge TH, Sawai ET, He Y, Li Y, Ray PE, Gutkind JSCancer cellEndothelial infection with KSHV genes in vivo reveals that vGPCR initiates Kaposi's sarcomagenesis and can promote the tumorigenic potential of viral latent genes. Cancer Cell. 2003 Jan; 3(1):23-36.Cancer Cell2003-01-01T00:00:002003Endothelial infection with KSHV genes in vivo reveals that vGPCR initiates Kaposi's sarcomagenesis and can promote the tumorigenic potential of viral latent genes.14668450Li Y, Welm B, Podsypanina K, Huang S, Chamorro M, Zhang X, Rowlands T, Egeblad M, Cowin P, Werb Z, Tan LK, Rosen JM, Varmus HEProceedings of the National Academy of Sciences of the United States of AmericaEvidence that transgenes encoding components of the Wnt signaling pathway preferentially induce mammary cancers from progenitor cells. Proc Natl Acad Sci U S A. 2003 Dec 23; 100(26):15853-8.Proc Natl Acad Sci U S A2003-12-10T00:00:002003Evidence that transgenes encoding components of the Wnt signaling pathway preferentially induce mammary cancers from progenitor cells.15198801Podsypanina K, Li Y, Varmus HEBMC medicineEvolution of somatic mutations in mammary tumors in transgenic mice is influenced by the inherited genotype. BMC Med. 2004 Jun 15; 2:24.BMC Med2004-06-15T00:00:002004Evolution of somatic mutations in mammary tumors in transgenic mice is influenced by the inherited genotype.15967113Hu X, Pandolfi PP, Li Y, Koutcher JA, Rosenblum M, Holland ECNeoplasia (New York, N.Y.)mTOR promotes survival and astrocytic characteristics induced by Pten/AKT signaling in glioblastoma. Neoplasia. 2005 Apr; 7(4):356-68.Neoplasia2005-04-01T00:00:002005mTOR promotes survival and astrocytic characteristics induced by Pten/AKT signaling in glioblastoma.16207355Huang S, Li Y, Chen Y, Podsypanina K, Chamorro M, Olshen AB, Desai KV, Tann A, Petersen D, Green JE, Varmus HEGenome biologyChanges in gene expression during the development of mammary tumors in MMTV-Wnt-1 transgenic mice. Genome Biol. 2005; 6(10):R84.Genome Biol2005-09-30T00:00:002005Changes in gene expression during the development of mammary tumors in MMTV-Wnt-1 transgenic mice.16790075Grimm SL, Bu W, Longley MA, Roop DR, Li Y, Rosen JMBreast cancer research : BCRKeratin 6 is not essential for mammary gland development. Breast Cancer Res. 2006; 8(3):R29.Breast Cancer Res2006-06-21T00:00:002006Keratin 6 is not essential for mammary gland development.17090666Du Z, Podsypanina K, Huang S, McGrath A, Toneff MJ, Bogoslovskaia E, Zhang X, Moraes RC, Fluck M, Allred DC, Lewis MT, Varmus HE, Li YProceedings of the National Academy of Sciences of the United States of AmericaIntroduction of oncogenes into mammary glands in vivo with an avian retroviral vector initiates and promotes carcinogenesis in mouse models. Proc Natl Acad Sci U S A. 2006 Nov 14; 103(46):17396-401.Proc Natl Acad Sci U S A2006-11-07T00:00:002006Introduction of oncogenes into mammary glands in vivo with an avian retroviral vector initiates and promotes carcinogenesis in mouse models.18283333Huang S, Chen Y, Podsypanina K, Li YNeoplasia (New York, N.Y.)Comparison of expression profiles of metastatic versus primary mammary tumors in MMTV-Wnt-1 and MMTV-Neu transgenic mice. Neoplasia. 2008 Feb; 10(2):118-24.Neoplasia2008-02-01T00:00:002008Comparison of expression profiles of metastatic versus primary mammary tumors in MMTV-Wnt-1 and MMTV-Neu transgenic mice.20133707Reddy JP, Peddibhotla S, Bu W, Zhao J, Haricharan S, Du YC, Podsypanina K, Rosen JM, Donehower LA, Li YProceedings of the National Academy of Sciences of the United States of AmericaDefining the ATM-mediated barrier to tumorigenesis in somatic mammary cells following ErbB2 activation. Proc Natl Acad Sci U S A. 2010 Feb 23; 107(8):3728-33.Proc Natl Acad Sci U S A2010-02-03T00:00:002010Defining the ATM-mediated barrier to tumorigenesis in somatic mammary cells following ErbB2 activation.20824048Toneff MJ, Du Z, Dong J, Huang J, Sinai P, Forman J, Hilsenbeck S, Schiff R, Huang S, Li YNeoplasia (New York, N.Y.)Somatic expression of PyMT or activated ErbB2 induces estrogen-independent mammary tumorigenesis. Neoplasia. 2010 Sep; 12(9):718-26.Neoplasia2010-09-01T00:00:002010Somatic expression of PyMT or activated ErbB2 induces estrogen-independent mammary tumorigenesis.21045149Lin T, Meng L, Li Y, Tsai RYCancer researchTumor-initiating function of nucleostemin-enriched mammary tumor cells. Cancer Res. 2010 Nov 15; 70(22):9444-52.Cancer Res2010-11-02T00:00:002010Tumor-initiating function of nucleostemin-enriched mammary tumor cells.21276786Visbal AP, LaMarca HL, Villanueva H, Toneff MJ, Li Y, Rosen JM, Lewis MTDevelopmental biologyAltered differentiation and paracrine stimulation of mammary epithelial cell proliferation by conditionally activated Smoothened. Dev Biol. 2011 Apr 01; 352(1):116-27.Dev Biol2011-01-27T00:00:002011Altered differentiation and paracrine stimulation of mammary epithelial cell proliferation by conditionally activated Smoothened.22140470Batts TD, Machado HL, Zhang Y, Creighton CJ, Li Y, Rosen JMPloS oneStem cell antigen-1 (sca-1) regulates mammary tumor development and cell migration. PLoS One. 2011; 6(11):e27841.PLoS One2011-11-29T00:00:002011Stem cell antigen-1 (sca-1) regulates mammary tumor development and cell migration.2ProfessorProfessor4ProfessorProfessortrue1ProfessorProfessortrue1ProfessorProfessortrue1ProfessorProfessor3ProfessorProfessorAuthorship 1071442D008321Anatomy1495330.740473Mammary Glands, AnimalAuthorship 1023997D008325Disorders2044930.762535Mammary Neoplasms, ExperimentalD015674Disorders1302210.835235Mammary Neoplasms, AnimalD050799Chemicals & Drugs1242140.896409STAT5 Transcription FactorD018719Chemicals & Drugs51925130.4861Receptor, ErbB-22010-04-30NIHLI, YI2005-05-06PROGENITOR CELLS AND ONCOGENE TARGETS IN BREAST CANCERR01CA1138692017-01-31NIHLI, YI2010-04-01Oncogene susceptibility: physiological state & breast cell differentiationR01CA1248202022-01-31NIHLI, YI2017-02-01A Novel LGR4 Oncogenic Signaling in Breast Cancer Progression and MetastasisR01CA2049262022-01-31NIHLI, YI2017-02-01Ruxolitinib for Preventing Breast Cancer in Women on NeurolepticsR01CA2055942017-11-30NIHLI, YI2015-12-01The cell of origin of breast cancer metastasisR21CA202227Principal InvestigatorPrincipal InvestigatorPrincipal InvestigatorPrincipal InvestigatorPrincipal InvestigatorDepartment of MedicineBreast CenterDepartment of Molecular & Cellular BiologyDepartment of Molecular Virology & MicrobiologyHuffington Center on AgingHuffington Ctr on AgingMedicine-Hematology & OncologyBreast Cancer CenterMolecular & Cellular BiologyMolecular Virology & MicrobiologyBaylor College of MedicineJIANMINGXUJIANMING XU0.000000000000000.000000000000003458XU, JIANMINGProfessorMICHAELLEWISMICHAEL LEWIS0.000000000000000.00000000000000353LEWIS, MICHAELProfessorWENBUWEN BU0.000000000000000.000000000000003840BU, WENAssistant ProfessorBILL R.BRINKLEYBILL R. BRINKLEY0.000000000000000.000000000000002270BRINKLEY, BILL R.Dean EmeritusJEFFREYROSENJEFFREY ROSEN0.000000000000000.000000000000002492ROSEN, JEFFREYDistinguished Service Professor3.049450.00361363373research areas1.54890.012199732coauthor of70.988610.862660similar to1156selected publicationsSHIXIAHUANGJaM5+WzGKKv3RYKj5X/XSHIXIA HUANG39.09225730000000-77.20961730000000559HUANG, SHIXIAProfessorSUSANHILSENBECKSUSAN HILSENBECK0.000000000000000.000000000000003634HILSENBECK, SUSANProfessorROYSMITHROY SMITH0.000000000000000.000000000000002519SMITH, ROYAdjunct ProfessorDAVIDLONARDDAVID LONARD0.000000000000000.000000000000003522LONARD, DAVIDProfessorAuthorship 1060071Authorship 109963323712846Wang Y, Dong J, Li D, Lai L, Siwko S, Li Y, Liu MStem cells (Dayton, Ohio)Lgr4 regulates mammary gland development and stem cell activity through the pluripotency transcription factor Sox2. Stem Cells. 2013 Sep; 31(9):1921-31.Stem Cells2013-09-01T00:00:002013Lgr4 regulates mammary gland development and stem cell activity through the pluripotency transcription factor Sox2.true1ProfessorProfessortrue1Dean EmeritusDean Emeritustrue1Distinguished Service ProfessorDistinguished Service ProfessorAuthorship 1170972Authorship 1134243https://www.bcm.edu/research/research-services/atc-core-labs/antibody-based-proteomicsAntibody-based Proteomics Corehttps://www.bcm.edu/academic-centers/dan-l-duncan-comprehensive-cancer-center/research/cancer-shared-resources/reverse-phase-protein-arrayReverse Phase Protein Arraytrue1Adjunct ProfessorAdjunct Professor23678002Xia Y, Yang W, Bu W, Ji H, Zhao X, Zheng Y, Lin X, Li Y, Lu ZThe Journal of biological chemistryDifferential regulation of c-Jun protein plays an instrumental role in chemoresistance of cancer cells. J Biol Chem. 2013 Jul 05; 288(27):19321-9.J Biol Chem2013-05-15T00:00:002013Differential regulation of c-Jun protein plays an instrumental role in chemoresistance of cancer cells.24265712Bu W, Zhang X, Dai H, Huang S, Li YPloS oneMammary cells with active Wnt signaling resist ErbB2-induced tumorigenesis. PLoS One. 2013; 8(11):e78720.PLoS One2013-11-12T00:00:002013Mammary cells with active Wnt signaling resist ErbB2-induced tumorigenesis.24381245Haricharan S, Dong J, Hein S, Reddy JP, Du Z, Toneff M, Holloway K, Hilsenbeck SG, Huang S, Atkinson R, Woodward W, Jindal S, Borges VF, Gutierrez C, Zhang H, Schedin PJ, Osborne CK, Tweardy DJ, Li YeLifeMechanism and preclinical prevention of increased breast cancer risk caused by pregnancy. Elife. 2013 Dec 31; 2:e00996.Elife2013-12-31T00:00:002013Mechanism and preclinical prevention of increased breast cancer risk caused by pregnancy.true1Assistant ProfessorAssistant ProfessorAuthorship 164086Authorship 1225494true1ProfessorProfessorAuthorship 170292true1ProfessorProfessortrue1ProfessorProfessortrue1ProfessorProfessortrue1ProfessorProfessor24317513Haricharan S, Hein SM, Dong J, Toneff MJ, Aina OH, Rao PH, Cardiff RD, Li YOncogeneContribution of an alveolar cell of origin to the high-grade malignant phenotype of pregnancy-associated breast cancer. 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