RUSSELLRAYRUSSELL RAY0.000000000000000.000000000000004416RAY, RUSSELLBrainstem
Breathing
Genetic engineering
Neural circuit mapping
Noradrenergic System
Fear
Anxiety
NeurodegenerationThe overarching goal of our laboratory is to understand how the myriad of neurons and glia in our brain are organized into circuits that keep us alive and enable complex behaviors that may be disrupted in diseases ranging from sudden infant death syndrome (SIDS), the leading cause of neonate death in the United States, to panic disorder, the most common mental illness in the United States. On the surface, SIDS and panic disorder may have little in common. However, there is indeed a likely nexus in the neural control of breathing. In SIDS, defined as the death of an infant for which no cause of death can be determined, the current thinking is that in many cases there are small-unseen abnormalities in brain regions that regulate breathing, leaving the infant vulnerable. Conversely, a connection between breathing and anxiety has long been appreciated, such that breathing challenges are used in clinical diagnostic tests for panic disorder and this relationship is best appreciated in our common perception of a panic attack where a person breaths too much and risks passing out. Unfortunately, little is known about these critical breathing circuits that are also important in spinal cord injuries where the number one desire for quadriplegic patients is to breath on their own, or in neuro-degenerative disorders such as Alzheimer’s, Parkinson’s and ALS, where the ultimate cause of death is typically respiratory arrest. Thus, we aim to define the neural pathways important in breathing to understand how they may be targeted for therapeutic interventions and predicative diagnostic tests.Associate Professorprns:coAuthorOfcoauthor ofprns:endDateend dateFaculty Rankprns:fullNamefull nameprns:grantAwardedBygrant awarded byprns:hasAuthorListauthor listprns:hasFacultyRankhas faculty rankprns:hasNetworkhas networkprns:hasPublicationVenuepublished inprns:informationResourceReferenceinformation resource referenceprns:isPrimaryPositionis primary positionprns:latitudelatitudeprns:longitudelongitudeprns:mainImagephotoprns:maxWeightmaximum weightprns:medlineTAjournal title abbreviationprns:meshDescriptorUIMeSH DescriptorUIprns:meshSemanticGroupNameMeSH semantic group nameprns:minWeightminimum weightprns:numberOfAuthorsnumber of authorsprns:numberOfConnectionsnumber of connectionsprns:numberOfPublicationsnumber of publicationsprns:personIdPerson IDprns:personInPrimaryPositionperson in primary positionprns:physicalNeighborOfphysical neighborprns:positionInDepartmentposition in departmentprns:positionInDivisionposition in divisionprns:predicateNodepredicate nodeprns:principalInvestigatorNameprincipal investigator nameprns:publicationDatepublication dateprns:similarTosimilar toprns:sortOrdersort orderprns:startDatestart dateprns:uniquenessWeightuniqueness weightprns:yearyearAcademic ArticleArticleDocumentbibo:pmidPubMed IdentifierAddressvivo:address1address line 1vivo:addressCitycityvivo:addressPostalCodepostal codevivo:addressStatestate or provinceAgreementvivo:authorInAuthorshipselected publicationsvivo:authorRankauthor rank in publicationAuthorshipDepartmentDivisionvivo:freetextKeywordkeywordsGrantvivo:hasResearchArearesearch areasvivo:hasResearcherRoleresearch activitiesvivo:hrJobTitleHR job titleInformation Resourcevivo:linkAnchorTextlink anchor textvivo:linkedAuthorlinked authorvivo:linkedInformationResourcelinked information resourcevivo:mailingAddressmailing addressvivo:overviewoverviewvivo:personInPositionpositionsPositionvivo:positionInOrganizationposition in organizationvivo:preferredTitlepreferred titleResearcher Rolevivo:researcherRoleOfresearcher role ofRolevivo:roleContributesTocontributes tovivo:sponsorAwardIdsponsor award idURLLinkvivo:webpagewebpagerdf:predicatepredicaterdf:typetyperdfs:labellabelConceptAgentfoaf:firstNamefirst namefoaf:lastNamelast nameOrganizationPersonGeneticsMD AndersonRICHARD RBEHRINGERRICHARD R BEHRINGER8600BEHRINGER, RICHARD RProfessorAuthorship 467912Authorship 304768326164374Landstrom AP, Sun JJ, Ray RS, Wehrens XHHeart rhythmIt's not the heart: autonomic nervous system predisposition to lethal ventricular arrhythmias. Heart Rhythm. 2015 Nov; 12(11):2294-5.Heart Rhythm2015-07-08T00:00:002015It's not the heart: autonomic nervous system predisposition to lethal ventricular arrhythmias.74Professor10Assistant Professor65Interim Chair14Associate Professor6Adjunct Professor47Distinguished Service ProfessorAuthorship 321034826928076Placzek AN, Molfese DL, Khatiwada S, Viana Di Prisco G, Huang W, Sidrauski C, Krnjevic K, Amos CL, Ray R, Dani JA, Walter P, Salas R, Costa-Mattioli MeLifeTranslational control of nicotine-evoked synaptic potentiation in mice and neuronal responses in human smokers by eIF2a. Elife. 2016 Mar 01; 5.Elife2016-03-01T00:00:002016Translational control of nicotine-evoked synaptic potentiation in mice and neuronal responses in human smokers by eIF2a.Authorship 325418227441631Sun JJ, Ray RPloS oneGeneration of Two Noradrenergic-Specific Dopamine-Beta-Hydroxylase-FLPo Knock-In Mice Using CRISPR/Cas9-Mediated Targeting in Embryonic Stem Cells. PLoS One. 2016; 11(7):e0159474.PLoS One2016-07-21T00:00:002016Generation of Two Noradrenergic-Specific Dopamine-Beta-Hydroxylase-FLPo Knock-In Mice Using CRISPR/Cas9-Mediated Targeting in Embryonic Stem Cells.One Baylor PlazaHouston, 77030TXAuthorship 6532491027638768Dharmadhikari AV, Sun JJ, Gogolewski K, Carofino BL, Ustiyan V, Hill M, Majewski T, Szafranski P, Justice MJ, Ray RS, Dickinson ME, Kalinichenko VV, Gambin A, Stankiewicz PBiology openLethal lung hypoplasia and vascular defects in mice with conditional Foxf1 overexpression. Biol Open. 2016 Nov 15; 5(11):1595-1606.Biol Open2016-11-15T00:00:002016Lethal lung hypoplasia and vascular defects in mice with conditional Foxf1 overexpression.19883998Ray RS, Dymecki SMCurrent opinion in cell biologyRautenlippe Redux -- toward a unified view of the precerebellar rhombic lip. Curr Opin Cell Biol. 2009 Dec; 21(6):741-7.Curr Opin Cell Biol2009-10-31T00:00:002009Rautenlippe Redux -- toward a unified view of the precerebellar rhombic lip.21798952Ray RS, Corcoran AE, Brust RD, Kim JC, Richerson GB, Nattie E, Dymecki SMScience (New York, N.Y.)Impaired respiratory and body temperature control upon acute serotonergic neuron inhibition. Science. 2011 Jul 29; 333(6042):637-42.Science2011-07-29T00:00:002011Impaired respiratory and body temperature control upon acute serotonergic neuron inhibition.Authorship 756677328213294Sun JJ, Nanu R, Ray RSJournal of pharmacological and toxicological methodsA low cost, simplified, and scaleable pneumotachograph and face mask for neonatal mouse respiratory measurements. J Pharmacol Toxicol Methods. 2017 Jul; 86:1-11.J Pharmacol Toxicol Methods2017-02-15T00:00:002017A low cost, simplified, and scaleable pneumotachograph and face mask for neonatal mouse respiratory measurements.Authorship 8689751328392070Yeh SY, Huang WH, Wang W, Ward CS, Chao ES, Wu Z, Tang B, Tang J, Sun JJ, Esther van der Heijden M, Gray PA, Xue M, Ray RS, Ren D, Zoghbi HYNeuronRespiratory Network Stability and Modulatory Response to Substance P Require Nalcn. Neuron. 2017 Apr 19; 94(2):294-303.e4.Neuron2017-04-06T00:00:002017Respiratory Network Stability and Modulatory Response to Substance P Require Nalcn.Authorship 874766228684394Sun JJ, Ray RSBiology openTg(Th-Cre)FI172Gsat (Th-Cre) defines neurons that are required for full hypercapnic and hypoxic reflexes. Biol Open. 2017 Aug 15; 6(8):1200-1208.Biol Open2017-08-15T00:00:002017Tg(Th-Cre)FI172Gsat (Th-Cre) defines neurons that are required for full hypercapnic and hypoxic reflexes.Authorship 87633626Authorship 8763372Authorship 87633825Authorship 876339110471505Geisler R, Rauch GJ, Baier H, van Bebber F, Bross L, Dekens MP, Finger K, Fricke C, Gates MA, Geiger H, Geiger-Rudolph S, Gilmour D, Glaser S, Gn?gge L, Habeck H, Hingst K, Holley S, Keenan J, Kirn A, Knaut H, Lashkari D, Maderspacher F, Martyn U, Neuhauss S, Neumann C, Nicolson T, Pelegri F, Ray R, Rick JM, Roehl H, Roeser T, Schauerte HE, Schier AF, Sch?nberger U, Sch?nthaler HB, Schulte-Merker S, Seydler C, Talbot WS, Weiler C, N?sslein-Volhard C, Haffter PNature geneticsA radiation hybrid map of the zebrafish genome. Nat Genet. 1999 Sep; 23(1):86-9.Nat Genet1999-09-01T00:00:001999A radiation hybrid map of the zebrafish genome.11376489Lee JS, Ray R, Chien CBDevelopmental dynamics : an official publication of the American Association of AnatomistsCloning and expression of three zebrafish roundabout homologs suggest roles in axon guidance and cell migration. Dev Dyn. 2001 Jun; 221(2):216-30.Dev Dyn2001-06-01T00:00:002001Cloning and expression of three zebrafish roundabout homologs suggest roles in axon guidance and cell migration.17212827Geisler R, Rauch GJ, Geiger-Rudolph S, Albrecht A, van Bebber F, Berger A, Busch-Nentwich E, Dahm R, Dekens MP, Dooley C, Elli AF, Gehring I, Geiger H, Geisler M, Glaser S, Holley S, Huber M, Kerr A, Kirn A, Knirsch M, Konantz M, K?chler AM, Maderspacher F, Neuhauss SC, Nicolson T, Ober EA, Praeg E, Ray R, Rentzsch B, Rick JM, Rief E, Schauerte HE, Schepp CP, Sch?nberger U, Schonthaler HB, Seiler C, Sidi S, S?llner C, Wehner A, Weiler C, N?sslein-Volhard CBMC genomicsLarge-scale mapping of mutations affecting zebrafish development. BMC Genomics. 2007 Jan 09; 8:11.BMC Genomics2007-01-09T00:00:002007Large-scale mapping of mutations affecting zebrafish development.19021736Ray R, Capecchi MEvolution & developmentAn examination of the Chiropteran HoxD locus from an evolutionary perspective. Evol Dev. 2008 Nov-Dec; 10(6):657-70.Evol Dev2008-11-01T00:00:002008An examination of the Chiropteran HoxD locus from an evolutionary perspective.20699143Dymecki SM, Ray RS, Kim JCMethods in enzymologyMapping cell fate and function using recombinase-based intersectional strategies. Methods Enzymol. 2010; 477:183-213.Methods Enzymol2010-01-01T00:00:002010Mapping cell fate and function using recombinase-based intersectional strategies.Authorship 885482428831138Sun JJ, Huang TW, Neul JL, Ray RSScientific reportsEmbryonic hindbrain patterning genes delineate distinct cardio-respiratory and metabolic homeostatic populations in the adult. Sci Rep. 2017 08 22; 7(1):9117.Sci Rep2017-08-22T00:00:002017Embryonic hindbrain patterning genes delineate distinct cardio-respiratory and metabolic homeostatic populations in the adult.true1Assistant ProfessorAssistant Professortrue1Distinguished Service ProfessorDistinguished Service ProfessorD009474Anatomy61422850.451917NeuronsD012119Physiology1974460.807936Respirationtrue1ProfessorProfessorD002118Chemicals & Drugs52915430.610901CalciumJEFFREYYAUJEFFREY YAU0.000000000000000.000000000000005694YAU, JEFFREYAssociate ProfessorD012249Anatomy30440.967633Rhombencephalon2020-12-31NIHRAY, RUSSELL S2019-01-01Rapid production and dissemination of intersectional genetic alleles for the study of nervous system circuit development and function in the mouse.R21OD0253272025-07-31NIHRAY, RUSSELL S2016-01-15Noradrenergic mechanisms in breathing and respiratory pathophysiologiesR01HL1302492013-07-31NIHRAY, RUSSELL S2010-08-01Brainstem GABAergic Neuron Development and FunctionF32HD063257Principal InvestigatorPrincipal InvestigatorPrincipal InvestigatorDepartment of MedicineDepartment of NeuroscienceDepartment of PediatricsDepartment of Molecular & Human GeneticsMedicine-EndocrinologyMolecular & Human GeneticsMolecular Physiology & BiophysicsNeurosciencePediatrics-NeurologyBaylor College of MedicineANDREASTOLIASANDREAS TOLIAS0.000000000000000.000000000000001062TOLIAS, ANDREASProfessorMAUROCOSTA-MATTIOLIMAURO COSTA-MATTIOLI0.000000000000000.000000000000001404COSTA-MATTIOLI, MAUROAdjunct ProfessorJOANNAJANKOWSKYJOANNA JANKOWSKY0.000000000000000.000000000000001407JANKOWSKY, JOANNAProfessor1.117070.00463143161research areas1.827740.035713426coauthor of15.20233.2120760similar to1124selected publicationsHUDAZOGHBIHUDA ZOGHBI29.71010310000000-95.397396100000002830ZOGHBI, HUDADistinguished Service ProfessorHUGOBELLENHUGO BELLEN29.71010310000000-95.397396100000003292BELLEN, HUGODistinguished Service ProfessorHEINRICHTAEGTMEYERHEINRICH TAEGTMEYER29.70508570000000-95.401808700000004081TAEGTMEYER, HEINRICHAdjunct ProfessorPAULPFAFFINGERPAUL PFAFFINGER0.000000000000000.000000000000003336PFAFFINGER, PAULProfessorXANDERWEHRENSXANDER WEHRENS0.000000000000000.00000000000000964WEHRENS, XANDERProfessorD064112Chemicals & DrugsGenes & Molecular Sequences65830.902518Clustered Regularly Interspaced Short Palindromic RepeatsAuthorship 947305831087036Egbert JR, Fahey PG, Reimer J, Owen CM, Evsikov AV, Nikolaev VO, Griesbeck O, Ray RS, Tolias AS, Jaffe LABiology of reproductionFollicle-stimulating hormone and luteinizing hormone increase Ca2+ in the granulosa cells of mouse ovarian follicles?. Biol Reprod. 2019 08 01; 101(2):433-444.Biol Reprod2019-08-01T00:00:002019Follicle-stimulating hormone and luteinizing hormone increase Ca2+ in the granulosa cells of mouse ovarian follicles?.Authorship 948852631178741Martinez VK, Saldana-Morales F, Sun JJ, Zhu PJ, Costa-Mattioli M, Ray RSFrontiers in physiologyOff-Target Effects of Clozapine-N-Oxide on the Chemosensory Reflex Are Masked by High Stress Levels. Front Physiol. 2019; 10:521.Front Physiol2019-05-22T00:00:002019Off-Target Effects of Clozapine-N-Oxide on the Chemosensory Reflex Are Masked by High Stress Levels.true1ProfessorProfessortrue1ProfessorProfessor71Postdoc Fellows and AssociatesPostDocRICHARDDEWELLRICHARD DEWELL0.000000000000000.000000000000006024DEWELL, RICHARDAssistant ProfessorJACOBREIMERJACOB REIMER0.000000000000000.000000000000006089REIMER, JACOBAssistant Professortrue1Postdoc Fellows and AssociatesPostdoc Fellows and AssociatesSavannahLuskSavannah Jane Lusk15552Lusk, SavannahPostdoc Fellows and AssociatesAuthorship 996934432791039Liu S, Wang ZF, Su YS, Ray RS, Jing XH, Wang YQ, Ma QNeuronSomatotopic Organization and Intensity Dependence in Driving Distinct NPY-Expressing Sympathetic Pathways by Electroacupuncture. Neuron. 2020 11 11; 108(3):436-450.e7.Neuron2020-08-12T00:00:002020Somatotopic Organization and Intensity Dependence in Driving Distinct NPY-Expressing Sympathetic Pathways by Electroacupuncture.http://flypush.imgen.bcm.tmc.eduBellen Lab WebsiteAuthorship 1005657533234943Chandrakantan A, Adler AC, Tohsun M, Kheradamand F, Ray RS, Roth SAnesthesia and analgesiaIntermittent Hypoxia and Effects on Early Learning/Memory: Exploring the Hippocampal Cellular Effects of Pediatric Obstructive Sleep Apnea. Anesth Analg. 2021 07 01; 133(1):93-103.Anesth Analg2021-07-01T00:00:002021Intermittent Hypoxia and Effects on Early Learning/Memory: Exploring the Hippocampal Cellular Effects of Pediatric Obstructive Sleep Apnea.true1Postdoc Fellows and AssociatesPostdoc Fellows and Associatestrue1Assistant ProfessorAssistant Professortrue1Associate ProfessorAssociate Professortrue1Distinguished Service ProfessorDistinguished Service ProfessorAuthorship 10390491635086530Lusk SJ, McKinney A, Hunt PJ, Fahey PG, Patel J, Chang A, Sun JJ, Martinez VK, Zhu PJ, Egbert JR, Allen G, Jiang X, Arenkiel BR, Tolias AS, Costa-Mattioli M, Ray RSBMC biologyA CRISPR toolbox for generating intersectional genetic mouse models for functional, molecular, and anatomical circuit mapping. BMC Biol. 2022 01 28; 20(1):28.BMC Biol2022-01-28T00:00:002022A CRISPR toolbox for generating intersectional genetic mouse models for functional, molecular, and anatomical circuit mapping.true1ProfessorProfessorDepartment of Integrative PhysiologyAuthorship 10603008Authorship 10549621336445327Iyer AA, Hosamani I, Nguyen JD, Cai T, Singh S, McGovern MM, Beyer L, Zhang H, Jen HI, Yousaf R, Birol O, Sun JJ, Ray RS, Raphael Y, Segil N, Groves AKeLifeCellular reprogramming with ATOH1, GFI1, and POU4F3 implicate epigenetic changes and cell-cell signaling as obstacles to hair cell regeneration in mature mammals. Elife. 2022 11 29; 11.Elife2022-11-29T00:00:002022Cellular reprogramming with ATOH1, GFI1, and POU4F3 implicate epigenetic changes and cell-cell signaling as obstacles to hair cell regeneration in mature mammals.36005011Fadel LC, Patel IV, Romero J, Tan IC, Kesler SR, Rao V, Subasinghe SAAS, Ray RS, Yustein JT, Allen MJ, Gibson BW, Verlinden JJ, Fayn S, Ruggiero N, Ortiz C, Hipskind E, Feng A, Iheanacho C, Wang A, Pautler RGBiosensorsA Mouse Holder for Awake Functional Imaging in Unanesthetized Mice: Applications in 31P Spectroscopy, Manganese-Enhanced Magnetic Resonance Imaging Studies, and Resting-State Functional Magnetic Resonance Imaging. Biosensors (Basel). 2022 Aug 08; 12(8).Biosensors (Basel)2022-08-08T00:00:002022A Mouse Holder for Awake Functional Imaging in Unanesthetized Mice: Applications in 31P Spectroscopy, Manganese-Enhanced Magnetic Resonance Imaging Studies, and Resting-State Functional Magnetic Resonance Imaging.true1Adjunct ProfessorAdjunct ProfessorAuthorship 1068748637090585Chang Y, Lusk S, Chang A, Ward CS, Ray RSbioRxiv : the preprint server for biologyVglut2-based glutamatergic signaling in central noradrenergic neurons is dispensable for normal breathing and chemosensory reflexes. bioRxiv. 2024 Feb 28.bioRxiv2024-02-28T00:00:002024Vglut2-based glutamatergic signaling in central noradrenergic neurons is dispensable for normal breathing and chemosensory reflexes.true1Associate ProfessorAssociate Professor2Associate ProfessorAssociate Professor3Associate ProfessorAssociate ProfessorDepartment of Biochemistry and Molecular PharmacologyBiochemistry & Mol PharmacologyAuthorship 1080253837786382Lusk S, Ward CS, Chang A, Twitchell-Heyne A, Fattig S, Allen G, Jankowsky JL, Ray RSThe Journal of physiologyAn automated respiratory data pipeline for waveform characteristic analysis. J Physiol. 2023 11; 601(21):4767-4806.J Physiol2023-10-03T00:00:002023An automated respiratory data pipeline for waveform characteristic analysis.true1Adjunct ProfessorAdjunct Professortrue1ProfessorProfessorAuthorship 418501PaulFAHEYPaul GERARD FAHEY7723FAHEY, PaulPostdoc Fellows and AssociatesAuthorship 715291