MIGUELCRUZMIGUEL CRUZ0.000000000000000.00000000000000235CRUZ, MIGUELProfessorprns:coAuthorOfcoauthor ofprns:endDateend dateFaculty Rankprns:fullNamefull nameprns:grantAwardedBygrant awarded byprns:hasAuthorListauthor listprns:hasFacultyRankhas faculty rankprns:hasNetworkhas networkprns:hasPublicationVenuepublished inprns:informationResourceReferenceinformation resource referenceprns:isPrimaryPositionis primary positionprns:latitudelatitudeprns:longitudelongitudeprns:mainImagephotoprns:maxWeightmaximum weightprns:medlineTAjournal title abbreviationprns:meshDescriptorUIMeSH DescriptorUIprns:meshSemanticGroupNameMeSH semantic group nameprns:minWeightminimum weightprns:numberOfAuthorsnumber of authorsprns:numberOfConnectionsnumber of connectionsprns:numberOfPublicationsnumber of publicationsprns:personIdPerson IDprns:personInPrimaryPositionperson in primary positionprns:physicalNeighborOfphysical neighborprns:positionInDepartmentposition in departmentprns:positionInDivisionposition in divisionprns:predicateNodepredicate nodeprns:principalInvestigatorNameprincipal investigator nameprns:publicationDatepublication dateprns:similarTosimilar toprns:sortOrdersort orderprns:startDatestart dateprns:uniquenessWeightuniqueness weightprns:yearyearAcademic ArticleArticleDocumentbibo:pmidPubMed IdentifierAddressvivo:address1address line 1vivo:addressCitycityvivo:addressPostalCodepostal codevivo:addressStatestate or provinceAgreementvivo:authorInAuthorshipselected publicationsvivo:authorRankauthor rank in publicationAuthorshipDepartmentDivisionGrantvivo:hasResearchArearesearch areasvivo:hasResearcherRoleresearch activitiesvivo:hrJobTitleHR job titleInformation Resourcevivo:linkAnchorTextlink anchor textvivo:linkedAuthorlinked authorvivo:linkedInformationResourcelinked information resourcevivo:mailingAddressmailing addressvivo:orcidIdORCID idvivo:personInPositionpositionsPositionvivo:positionInOrganizationposition in organizationvivo:preferredTitlepreferred titleResearcher Rolevivo:researcherRoleOfresearcher role ofRolevivo:roleContributesTocontributes tovivo:sponsorAwardIdsponsor award idURLLinkvivo:webpagewebpagerdf:predicatepredicaterdf:typetyperdfs:labellabelConceptAgentfoaf:firstNamefirst namefoaf:lastNamelast nameOrganizationPersonAuthorship 929913Authorship 952244Authorship 955711Authorship 1206825Authorship 1214343Authorship 161999725769494Nguyen TC, Gushiken F, Correa JI, Dong JF, Dasgupta SK, Thiagarajan P, Cruz MAThrombosis researchA recombinant fragment of von Willebrand factor reduces fibrin-rich microthrombi formation in mice with endotoxemia. Thromb Res. 2015 May; 135(5):1025-30.Thromb Res2015-03-03T00:00:002015A recombinant fragment of von Willebrand factor reduces fibrin-rich microthrombi formation in mice with endotoxemia.Authorship 273766Authorship 333883Authorship 438701Authorship 97957792748Beacham DA, Cruz MA, Handin RIThrombosis and haemostasisGlycoprotein Ib can mediate endothelial cell attachment to a von Willebrand factor substratum. Thromb Haemost. 1995 Feb; 73(2):309-17.Thromb Haemost1995-02-01T00:00:001995Glycoprotein Ib can mediate endothelial cell attachment to a von Willebrand factor substratum.Authorship 2811436Authorship 28114477738019Cruz MA, Yuan H, Lee JR, Wise RJ, Handin RIThe Journal of biological chemistryInteraction of the von Willebrand factor (vWF) with collagen. Localization of the primary collagen-binding site by analysis of recombinant vWF a domain polypeptides. J Biol Chem. 1995 May 05; 270(18):10822-7.J Biol Chem1995-05-05T00:00:001995Interaction of the von Willebrand factor (vWF) with collagen. Localization of the primary collagen-binding site by analysis of recombinant vWF a domain polypeptides.26307534Da Q, Teruya M, Guchhait P, Teruya J, Olson JS, Cruz MABloodFree hemoglobin increases von Willebrand factor-mediated platelet adhesion in vitro: implications for circulatory devices. Blood. 2015 Nov 12; 126(20):2338-41.Blood2015-08-25T00:00:002015Free hemoglobin increases von Willebrand factor-mediated platelet adhesion in vitro: implications for circulatory devices.26341739Singhal R, Annarapu GK, Pandey A, Chawla S, Ojha A, Gupta A, Cruz MA, Seth T, Guchhait PHaematologicaHemoglobin interaction with GP1ba induces platelet activation and apoptosis: a novel mechanism associated with intravascular hemolysis. Haematologica. 2015 Dec; 100(12):1526-33.Haematologica2015-09-04T00:00:002015Hemoglobin interaction with GP1ba induces platelet activation and apoptosis: a novel mechanism associated with intravascular hemolysis.8407961Cruz MA, Handin RI, Wise RJThe Journal of biological chemistryThe interaction of the von Willebrand factor-A1 domain with platelet glycoprotein Ib/IX. The role of glycosylation and disulfide bonding in a monomeric recombinant A1 domain protein. J Biol Chem. 1993 Oct 05; 268(28):21238-45.J Biol Chem1993-10-05T00:00:001993The interaction of the von Willebrand factor-A1 domain with platelet glycoprotein Ib/IX. The role of glycosylation and disulfide bonding in a monomeric recombinant A1 domain protein.9373253Schulte am Esch J, Cruz MA, Siegel JB, Anrather J, Robson SCBloodActivation of human platelets by the membrane-expressed A1 domain of von Willebrand factor. Blood. 1997 Dec 01; 90(11):4425-37.Blood1997-12-01T00:00:001997Activation of human platelets by the membrane-expressed A1 domain of von Willebrand factor.Authorship 2983695Authorship 299035226213126Ju L, Chen Y, Zhou F, Lu H, Cruz MA, Zhu CThrombosis researchVon Willebrand factor-A1 domain binds platelet glycoprotein Iba in multiple states with distinctive force-dependent dissociation kinetics. Thromb Res. 2015 Sep; 136(3):606-12.Thromb Res2015-06-20T00:00:002015Von Willebrand factor-A1 domain binds platelet glycoprotein Iba in multiple states with distinctive force-dependent dissociation kinetics.26410136Nguyen TC, Cruz MA, Carcillo JACritical care clinicsThrombocytopenia-Associated Multiple Organ Failure and Acute Kidney Injury. Crit Care Clin. 2015 Oct; 31(4):661-74.Crit Care Clin2015-08-07T00:00:002015Thrombocytopenia-Associated Multiple Organ Failure and Acute Kidney Injury.2002 HOLCOMBEHouston, 77030TX10585478Estavillo D, Ritchie A, Diacovo TG, Cruz MAThe Journal of biological chemistryFunctional analysis of a recombinant glycoprotein Ia/IIa (Integrin alpha(2)beta(1)) I domain that inhibits platelet adhesion to collagen and endothelial matrix under flow conditions. J Biol Chem. 1999 Dec 10; 274(50):35921-6.J Biol Chem1999-12-10T00:00:001999Functional analysis of a recombinant glycoprotein Ia/IIa (Integrin alpha(2)beta(1)) I domain that inhibits platelet adhesion to collagen and endothelial matrix under flow conditions.12010796Arya M, Anvari B, Romo GM, Cruz MA, Dong JF, McIntire LV, Moake JL, L?pez JABloodUltralarge multimers of von Willebrand factor form spontaneous high-strength bonds with the platelet glycoprotein Ib-IX complex: studies using optical tweezers. Blood. 2002 Jun 01; 99(11):3971-7.Blood2002-06-01T00:00:002002Ultralarge multimers of von Willebrand factor form spontaneous high-strength bonds with the platelet glycoprotein Ib-IX complex: studies using optical tweezers.10660584Smith C, Estavillo D, Emsley J, Bankston LA, Liddington RC, Cruz MAThe Journal of biological chemistryMapping the collagen-binding site in the I domain of the glycoprotein Ia/IIa (integrin alpha(2)beta(1)). J Biol Chem. 2000 Feb 11; 275(6):4205-9.J Biol Chem2000-02-11T00:00:002000Mapping the collagen-binding site in the I domain of the glycoprotein Ia/IIa (integrin alpha(2)beta(1)).Authorship 315407227013650Lam FW, Cruz MA, Parikh K, Rumbaut REHaematologicaHistones stimulate von Willebrand factor release in vitro and in vivo. Haematologica. 2016 07; 101(7):e277-9.Haematologica2016-03-24T00:00:002016Histones stimulate von Willebrand factor release in vitro and in vivo.12871332Borthakur G, Cruz MA, Dong JF, McIntire L, Li F, L?pez JA, Thiagarajan PJournal of thrombosis and haemostasis : JTHSulfatides inhibit platelet adhesion to von Willebrand factor in flowing blood. J Thromb Haemost. 2003 Jun; 1(6):1288-95.J Thromb Haemost2003-06-01T00:00:002003Sulfatides inhibit platelet adhesion to von Willebrand factor in flowing blood.15319289Peng Y, Berndt MC, Cruz MA, L?pez JABloodThe alpha1 helix-beta13 strand spanning Leu214 to Val229 of platelet glycoprotein Ibalpha facilitates the interaction with von Willebrand factor: evidence from characterization of the epitope of monoclonal antibody AP1. Blood. 2004 Dec 15; 104(13):3971-8.Blood2004-08-19T00:00:002004The alpha1 helix-beta13 strand spanning Leu214 to Val229 of platelet glycoprotein Ibalpha facilitates the interaction with von Willebrand factor: evidence from characterization of the epitope of monoclonal antibody AP1.74Professor10Assistant Professor54Instructor29Clinical Associate Professor21Chair14Associate Professor78Professor Emeritus6Adjunct Professor12646253Schulte am Esch J, Robson SC, Cruz MABiochemical and biophysical research communicationsPlatelet aggregation by membrane-expressed A1 domains of von Willebrand Factor is dependent on residues Asp 560 and Gly 561. Biochem Biophys Res Commun. 2003 Mar 21; 302(4):873-7.Biochem Biophys Res Commun2003-03-21T00:00:002003Platelet aggregation by membrane-expressed A1 domains of von Willebrand Factor is dependent on residues Asp 560 and Gly 561.16195328Lasser G, Guchhait P, Ellsworth JL, Sheppard P, Lewis K, Bishop P, Cruz MA, Lopez JA, Fruebis JBloodC1qTNF-related protein-1 (CTRP-1): a vascular wall protein that inhibits collagen-induced platelet aggregation by blocking VWF binding to collagen. Blood. 2006 Jan 15; 107(2):423-30.Blood2005-09-29T00:00:002005C1qTNF-related protein-1 (CTRP-1): a vascular wall protein that inhibits collagen-induced platelet aggregation by blocking VWF binding to collagen.12871313Arya M, L?pez JA, Romo GM, Cruz MA, Kasirer-Friede A, Shattil SJ, Anvari BJournal of thrombosis and haemostasis : JTHGlycoprotein Ib-IX-mediated activation of integrin alpha(IIb)beta(3): effects of receptor clustering and von Willebrand factor adhesion. J Thromb Haemost. 2003 Jun; 1(6):1150-7.J Thromb Haemost2003-06-01T00:00:002003Glycoprotein Ib-IX-mediated activation of integrin alpha(IIb)beta(3): effects of receptor clustering and von Willebrand factor adhesion.12121649Fukuda K, Doggett TA, Bankston LA, Cruz MA, Diacovo TG, Liddington RCStructure (London, England : 1993)Structural basis of von Willebrand factor activation by the snake toxin botrocetin. Structure. 2002 Jul; 10(7):943-50.Structure2002-07-01T00:00:002002Structural basis of von Willebrand factor activation by the snake toxin botrocetin.Authorship 324728627334924Khatlani T, Pradhan S, Da Q, Shaw T, Buchman VL, Cruz MA, Vijayan KVThe Journal of biological chemistryA Novel Interaction of the Catalytic Subunit of Protein Phosphatase 2A with the Adaptor Protein CIN85 Suppresses Phosphatase Activity and Facilitates Platelet Outside-in aIIb?3 Integrin Signaling. J Biol Chem. 2016 08 12; 291(33):17360-8.J Biol Chem2016-06-22T00:00:002016A Novel Interaction of the Catalytic Subunit of Protein Phosphatase 2A with the Adaptor Protein CIN85 Suppresses Phosphatase Activity and Facilitates Platelet Outside-in aIIb?3 Integrin Signaling.14652658Cruz MA, Whitelock J, Dong JFThrombosis and haemostasisEvaluation of ADAMTS-13 activity in plasma using recombinant von Willebrand Factor A2 domain polypeptide as substrate. Thromb Haemost. 2003 Dec; 90(6):1204-9.Thromb Haemost2003-12-01T00:00:002003Evaluation of ADAMTS-13 activity in plasma using recombinant von Willebrand Factor A2 domain polypeptide as substrate.Authorship 326963427627652Dasgupta SK, Le A, Da Q, Cruz M, Rumbaut RE, Thiagarajan PPloS oneWdr1-Dependent Actin Reorganization in Platelet Activation. PLoS One. 2016; 11(9):e0162897.PLoS One2016-09-14T00:00:002016Wdr1-Dependent Actin Reorganization in Platelet Activation.17389010Martin C, Morales LD, Cruz MAJournal of thrombosis and haemostasis : JTHPurified A2 domain of von Willebrand factor binds to the active conformation of von Willebrand factor and blocks the interaction with platelet glycoprotein Ibalpha. J Thromb Haemost. 2007 Jul; 5(7):1363-70.J Thromb Haemost2007-03-27T00:00:002007Purified A2 domain of von Willebrand factor binds to the active conformation of von Willebrand factor and blocks the interaction with platelet glycoprotein Ibalpha.15102023Bernardo A, Bergeron AL, Sun CW, Guchhait P, Cruz MA, L?pez JA, Dong JFJournal of thrombosis and haemostasis : JTHVon Willebrand factor present in fibrillar collagen enhances platelet adhesion to collagen and collagen-induced platelet aggregation. J Thromb Haemost. 2004 Apr; 2(4):660-9.J Thromb Haemost2004-04-01T00:00:002004Von Willebrand factor present in fibrillar collagen enhances platelet adhesion to collagen and collagen-induced platelet aggregation.14645097Kumar RA, Dong JF, Thaggard JA, Cruz MA, L?pez JA, McIntire LVBiophysical journalKinetics of GPIbalpha-vWF-A1 tether bond under flow: effect of GPIbalpha mutations on the association and dissociation rates. Biophys J. 2003 Dec; 85(6):4099-109.Biophys J2003-12-01T00:00:002003Kinetics of GPIbalpha-vWF-A1 tether bond under flow: effect of GPIbalpha mutations on the association and dissociation rates.20498367Auton M, Sowa KE, Smith SM, Sedl?k E, Vijayan KV, Cruz MAThe Journal of biological chemistryDestabilization of the A1 domain in von Willebrand factor dissociates the A1A2A3 tri-domain and provokes spontaneous binding to glycoprotein Ibalpha and platelet activation under shear stress. J Biol Chem. 2010 Jul 23; 285(30):22831-9.J Biol Chem2010-05-24T00:00:002010Destabilization of the A1 domain in von Willebrand factor dissociates the A1A2A3 tri-domain and provokes spontaneous binding to glycoprotein Ibalpha and platelet activation under shear stress.15304055Dong JF, Whitelock J, Bernardo A, Ball C, Cruz MAJournal of thrombosis and haemostasis : JTHVariations among normal individuals in the cleavage of endothelial-derived ultra-large von Willebrand factor under flow. J Thromb Haemost. 2004 Aug; 2(8):1460-6.J Thromb Haemost2004-08-01T00:00:002004Variations among normal individuals in the cleavage of endothelial-derived ultra-large von Willebrand factor under flow.20713003Auton M, Zhu C, Cruz MABiophysical journalThe mechanism of VWF-mediated platelet GPIbalpha binding. Biophys J. 2010 Aug 09; 99(4):1192-201.Biophys J2010-08-09T00:00:002010The mechanism of VWF-mediated platelet GPIbalpha binding.15514009Cruz MA, Chen J, Whitelock JL, Morales LD, L?pez JABloodThe platelet glycoprotein Ib-von Willebrand factor interaction activates the collagen receptor alpha2beta1 to bind collagen: activation-dependent conformational change of the alpha2-I domain. Blood. 2005 Mar 01; 105(5):1986-91.Blood2004-10-28T00:00:002004The platelet glycoprotein Ib-von Willebrand factor interaction activates the collagen receptor alpha2beta1 to bind collagen: activation-dependent conformational change of the alpha2-I domain.21244826Coburn LA, Damaraju VS, Dozic S, Eskin SG, Cruz MA, McIntire LVBiophysical journalGPIba-vWF rolling under shear stress shows differences between type 2B and 2M von Willebrand disease. Biophys J. 2011 Jan 19; 100(2):304-12.Biophys J2011-01-19T00:00:002011GPIba-vWF rolling under shear stress shows differences between type 2B and 2M von Willebrand disease.MARINAMARTINEZ-VARGASMARINA MARTINEZ-VARGAS12322MARTINEZ-VARGAS, MARINAInstructor22080766Yan R, Mo X, Paredes AM, Dai K, Lanza F, Cruz MA, Li RBiochemistryReconstitution of the platelet glycoprotein Ib-IX complex in phospholipid bilayer Nanodiscs. Biochemistry. 2011 Dec 13; 50(49):10598-606.Biochemistry2011-11-18T00:00:002011Reconstitution of the platelet glycoprotein Ib-IX complex in phospholipid bilayer Nanodiscs.16420575Morales LD, Martin C, Cruz MAJournal of thrombosis and haemostasis : JTHThe interaction of von Willebrand factor-A1 domain with collagen: mutation G1324S (type 2M von Willebrand disease) impairs the conformational change in A1 domain induced by collagen. J Thromb Haemost. 2006 Feb; 4(2):417-25.J Thromb Haemost2006-02-01T00:00:002006The interaction of von Willebrand factor-A1 domain with collagen: mutation G1324S (type 2M von Willebrand disease) impairs the conformational change in A1 domain induced by collagen.Authorship 100195718725999Yago T, Lou J, Wu T, Yang J, Miner JJ, Coburn L, L?pez JA, Cruz MA, Dong JF, McIntire LV, McEver RP, Zhu CThe Journal of clinical investigationPlatelet glycoprotein Ibalpha forms catch bonds with human WT vWF but not with type 2B von Willebrand disease vWF. J Clin Invest. 2008 Sep; 118(9):3195-207.J Clin Invest2008-09-01T00:00:002008Platelet glycoprotein Ibalpha forms catch bonds with human WT vWF but not with type 2B von Willebrand disease vWF.20016849Gushiken FC, Hyojeong H, Pradhan S, Langlois KW, Alrehani N, Cruz MA, Rumbaut RE, Vijayan KVPloS oneThe catalytic subunit of protein phosphatase 1 gamma regulates thrombin-induced murine platelet alpha(IIb)beta(3) function. PLoS One. 2009 Dec 15; 4(12):e8304.PLoS One2009-12-15T00:00:002009The catalytic subunit of protein phosphatase 1 gamma regulates thrombin-induced murine platelet alpha(IIb)beta(3) function.Authorship 868341528294518Da Q, Shaw T, Pradhan S, Roche PA, Cruz MA, Vijayan KVJournal of thrombosis and haemostasis : JTHDisruption of protein complexes containing protein phosphatase?2B and Munc18c reduces the secretion of von Willebrand factor from endothelial cells. J Thromb Haemost. 2017 05; 15(5):1032-1039.J Thromb Haemost2017-04-13T00:00:002017Disruption of protein complexes containing protein phosphatase?2B and Munc18c reduces the secretion of von Willebrand factor from endothelial cells.10764791Cruz MA, Diacovo TG, Emsley J, Liddington R, Handin RIThe Journal of biological chemistryMapping the glycoprotein Ib-binding site in the von willebrand factor A1 domain. J Biol Chem. 2000 Jun 23; 275(25):19098-105.J Biol Chem2000-06-23T00:00:002000Mapping the glycoprotein Ib-binding site in the von willebrand factor A1 domain.28682993Zhou Y, Qin S, Hilton T, Tang L, Cruz M, Hernandez R, Moake JL, Tian Q, Frazier OH, Dong JF, Nascimbene AASAIO journal (American Society for Artificial Internal Organs : 1992)Quantification of Von Willebrand Factor Cleavage by adamts-13 in Patients Supported by Left Ventricular Assist Devices. ASAIO J. 2017 Nov/Dec; 63(6):849-853.ASAIO J2017-11-01T00:00:002017Quantification of Von Willebrand Factor Cleavage by adamts-13 in Patients Supported by Left Ventricular Assist Devices.Authorship 875363412775718Dong JF, Moake JL, Bernardo A, Fujikawa K, Ball C, Nolasco L, L?pez JA, Cruz MAThe Journal of biological chemistryADAMTS-13 metalloprotease interacts with the endothelial cell-derived ultra-large von Willebrand factor. J Biol Chem. 2003 Aug 08; 278(32):29633-9.J Biol Chem2003-05-29T00:00:002003ADAMTS-13 metalloprotease interacts with the endothelial cell-derived ultra-large von Willebrand factor.15009467Whitelock JL, Nolasco L, Bernardo A, Moake J, Dong JF, Cruz MAJournal of thrombosis and haemostasis : JTHADAMTS-13 activity in plasma is rapidly measured by a new ELISA method that uses recombinant VWF-A2 domain as substrate. J Thromb Haemost. 2004 Mar; 2(3):485-91.J Thromb Haemost2004-03-01T00:00:002004ADAMTS-13 activity in plasma is rapidly measured by a new ELISA method that uses recombinant VWF-A2 domain as substrate.1730650Cruz MA, Petersen E, Turci SM, Handin RIThe Journal of biological chemistryFunctional analysis of a recombinant glycoprotein Ib alpha polypeptide which inhibits von Willebrand factor binding to the platelet glycoprotein Ib-IX complex and to collagen. J Biol Chem. 1992 Jan 15; 267(2):1303-9.J Biol Chem1992-01-15T00:00:001992Functional analysis of a recombinant glycoprotein Ib alpha polypeptide which inhibits von Willebrand factor binding to the platelet glycoprotein Ib-IX complex and to collagen.15764659Arya M, Kolomeisky AB, Romo GM, Cruz MA, L?pez JA, Anvari BBiophysical journalDynamic force spectroscopy of glycoprotein Ib-IX and von Willebrand factor. Biophys J. 2005 Jun; 88(6):4391-401.Biophys J2005-03-11T00:00:002005Dynamic force spectroscopy of glycoprotein Ib-IX and von Willebrand factor.17187823Auton M, Cruz MA, Moake JJournal of molecular biologyConformational stability and domain unfolding of the Von Willebrand factor A domains. J Mol Biol. 2007 Feb 23; 366(3):986-1000.J Mol Biol2006-10-25T00:00:002006Conformational stability and domain unfolding of the Von Willebrand factor A domains.18327408Dong JF, Cruz MA, Aboulfatova K, Martin C, Choi H, Bergeron AL, Martini SR, Kroll MH, Kent TAThrombosis and haemostasisMagnesium maintains endothelial integrity, up-regulates proteolysis of ultra-large von Willebrand factor, and reduces platelet aggregation under flow conditions. Thromb Haemost. 2008 Mar; 99(3):586-93.Thromb Haemost2008-03-01T00:00:002008Magnesium maintains endothelial integrity, up-regulates proteolysis of ultra-large von Willebrand factor, and reduces platelet aggregation under flow conditions.19492149Zhou Z, Han H, Cruz MA, L?pez JA, Dong JF, Guchhait PThrombosis and haemostasisHaemoglobin blocks von Willebrand factor proteolysis by ADAMTS-13: a mechanism associated with sickle cell disease. Thromb Haemost. 2009 Jun; 101(6):1070-7.Thromb Haemost2009-06-01T00:00:002009Haemoglobin blocks von Willebrand factor proteolysis by ADAMTS-13: a mechanism associated with sickle cell disease.19619477Auton M, Sedl?k E, Marek J, Wu T, Zhu C, Cruz MABiophysical journalChanges in thermodynamic stability of von Willebrand factor differentially affect the force-dependent binding to platelet GPIbalpha. Biophys J. 2009 Jul 22; 97(2):618-27.Biophys J2009-07-22T00:00:002009Changes in thermodynamic stability of von Willebrand factor differentially affect the force-dependent binding to platelet GPIbalpha.19897584Wu T, Lin J, Cruz MA, Dong JF, Zhu CBloodForce-induced cleavage of single VWFA1A2A3 tridomains by ADAMTS-13. Blood. 2010 Jan 14; 115(2):370-8.Blood2009-11-06T00:00:002009Force-induced cleavage of single VWFA1A2A3 tridomains by ADAMTS-13.22431729Auton M, Sowa KE, Behymer M, Cruz MAThe Journal of biological chemistryN-terminal flanking region of A1 domain in von Willebrand factor stabilizes structure of A1A2A3 complex and modulates platelet activation under shear stress. J Biol Chem. 2012 Apr 27; 287(18):14579-85.J Biol Chem2012-03-19T00:00:002012N-terminal flanking region of A1 domain in von Willebrand factor stabilizes structure of A1A2A3 complex and modulates platelet activation under shear stress.29335256Lam FW, Da Q, Guillory B, Cruz MAJournal of immunology (Baltimore, Md. : 1950)Recombinant Human Vimentin Binds to P-Selectin and Blocks Neutrophil Capture and Rolling on Platelets and Endothelium. J Immunol. 2018 03 01; 200(5):1718-1726.J Immunol2018-01-15T00:00:002018Recombinant Human Vimentin Binds to P-Selectin and Blocks Neutrophil Capture and Rolling on Platelets and Endothelium.Authorship 8816704ANDREWYEEANDREW YEE13560YEE, ANDREW0000-0003-0304-6322Assistant Professortrue1InstructorInstructortrue1ProfessorProfessortrue1Associate ProfessorAssociate Professortrue1Assistant ProfessorAssistant ProfessorD014841Chemicals & Drugs823350.817312von Willebrand FactorD019038Chemicals & Drugs18730.961321Platelet Glycoprotein GPIb-IX ComplexAuthorship 9165163Authorship 940168830175099Valladolid C, Yee A, Cruz MAFrontiers in medicinevon Willebrand Factor, Free Hemoglobin and Thrombosis in ECMO. Front Med (Lausanne). 2018; 5:228.Front Med (Lausanne)2018-08-17T00:00:002018von Willebrand Factor, Free Hemoglobin and Thrombosis in ECMO.30355099Fasipe TA, Hong SH, Da Q, Valladolid C, Lahey MT, Richards LM, Dunn AK, Cruz MA, Marrelli SPStrokeExtracellular Vimentin/VWF (von Willebrand Factor) Interaction Contributes to VWF String Formation and Stroke Pathology. Stroke. 2018 10; 49(10):2536-2540.Stroke2018-10-01T00:00:002018Extracellular Vimentin/VWF (von Willebrand Factor) Interaction Contributes to VWF String Formation and Stroke Pathology.D013927AnatomyDisorders3747820.603758ThrombosisD001792Anatomy2817310.683535Blood Platelets2023-07-31NIHCRUZ, MIGUEL ANGEL;RUMBAUT, ROLANDO E2018-08-01Collaborative Research Training in Thrombosis and InflammationT32HL1394252021-05-31NIHCRUZ, MIGUEL ANGEL2016-09-01Role of vimentin in thrombosis and strokeR01NS0942802020-07-31NIHCRUZ, MIGUEL ANGEL2018-08-20Novel treatment for DICR41HL1359422023-06-30NIHCRUZ, MIGUEL ANGEL2014-09-25Microvascular Thrombosis in systemic inflammationR01GM1128062009-11-30NIHCRUZ, MIGUEL ANGEL2003-12-08Molecular Basis of Platelet AdhesionR01HL072886Principal InvestigatorPrincipal InvestigatorCo-Principal InvestigatorPrincipal InvestigatorPrincipal InvestigatorAuthorship 1088204D010973Physiology22570.968982Platelet AdhesivenessDepartment of MedicineDepartment of PediatricsDepartment of SurgerySurgeryMedicine-CardiologyMedicine-EndocrinologyMedicine-General MedicineMedicine-Hematology & OncologyMedicine-Infectious DiseaseMedicine-PulmonaryMedicine-Thrombosis ResearchPediatrics-Critical CarePediatrics-HematologyPediatrics-Hematology & OncologyBaylor College of MedicineJING-FEIDONGJING-FEI DONG0.000000000000000.000000000000003459DONG, JING-FEIAdjunct ProfessorZHUYONGMEIZHUYONG MEI0.000000000000000.000000000000003616MEI, ZHUYONGAssociate Professor7.065720.00616031312research areas2.675720.050534644coauthor of93.69536.8488960similar to1180selected publicationsROLANDORUMBAUTROLANDO RUMBAUT29.70508570000000-95.40180870000000229RUMBAUT, ROLANDOProfessorTODDROSENGARTTODD ROSENGART0.000000000000000.000000000000004672ROSENGART, TODDProfessorTRUNGNGUYENTRUNG NGUYEN0.000000000000000.00000000000000644NGUYEN, TRUNGAssociate ProfessorNEALKLEIMANNEAL KLEIMAN29.70991060000000-95.401413900000002919KLEIMAN, NEALAdjunct ProfessorJOELMOAKEJOEL MOAKE29.70508570000000-95.401808700000003057MOAKE, JOELProfessor EmeritusNANCYDUFRANENANCY DUFRANE0.000000000000000.00000000000000849DUFRANE, NANCYInstructorAuthorship 941077830864273Da Q, Han H, Valladolid C, Fern?ndez M, Khatlani T, Pradhan S, Nolasco J, Matsunami RK, Engler DA, Cruz MA, Vijayan KVJournal of thrombosis and haemostasis : JTHIn vitro phosphorylation of von Willebrand factor by FAM20c enhances its ability to support platelet adhesion. J Thromb Haemost. 2019 06; 17(6):866-877.J Thromb Haemost2019-04-05T00:00:002019In vitro phosphorylation of von Willebrand factor by FAM20c enhances its ability to support platelet adhesion.FONGLAMFONG LAM0.000000000000000.000000000000003477LAM, FONGAssociate ProfessorHOONMOKOOHOONMO KOO0.000000000000000.00000000000000883KOO, HOONMOClinical Associate ProfessorAuthorship 109625Authorship 1262602Authorship 946604431067148Li Z, Lin J, Sulchek T, Cruz MA, Wu J, Dong JF, Zhu CMolecular biology of the cellDomain-specific mechanical modulation of VWF-ADAMTS13 interaction. Mol Biol Cell. 2019 07 22; 30(16):1920-1929.Mol Biol Cell2019-05-08T00:00:002019Domain-specific mechanical modulation of VWF-ADAMTS13 interaction.Authorship 1274202Authorship 127764323673386Lam FW, Cruz MA, Leung HC, Parikh KS, Smith CW, Rumbaut REThrombosis researchHistone induced platelet aggregation is inhibited by normal albumin. Thromb Res. 2013 Jul; 132(1):69-76.Thromb Res2013-05-11T00:00:002013Histone induced platelet aggregation is inhibited by normal albumin.23775931Tischer A, Cruz MA, Auton MProtein science : a publication of the Protein SocietyThe linker between the D3 and A1 domains of vWF suppresses A1-GPIba catch bonds by site-specific binding to the A1 domain. Protein Sci. 2013 Aug; 22(8):1049-59.Protein Sci2013-08-01T00:00:002013The linker between the D3 and A1 domains of vWF suppresses A1-GPIba catch bonds by site-specific binding to the A1 domain.23991205Feng S, Liang X, Cruz MA, Vu H, Zhou Z, Pemmaraju N, Dong JF, Kroll MH, Afshar-Kharghan VPloS oneThe interaction between factor H and Von Willebrand factor. PLoS One. 2013; 8(8):e73715.PLoS One2013-08-26T00:00:002013The interaction between factor H and Von Willebrand factor.Authorship 947238731080944Nolasco JG, Nolasco LH, Da Q, Cirlos S, Ruggeri ZM, Moake JL, Cruz MATH open : companion journal to thrombosis and haemostasisComplement Component C3 Binds to the A3 Domain of von Willebrand Factor. TH Open. 2018; 2(3):e338-e345.TH Open2018-01-01T00:00:002018Complement Component C3 Binds to the A3 Domain of von Willebrand Factor.true1Associate ProfessorAssociate ProfessorAuthorship 1116112Authorship 9575181431628947Tischer A, Brehm MA, Machha VR, Moon-Tasson L, Benson LM, Nelton KJ, Leger RR, Obser T, Martinez-Vargas M, Whitten ST, Chen D, Pruthi RK, Bergen HR, Cruz MA, Schneppenheim R, Auton MJournal of molecular biologyEvidence for the Misfolding of the A1 Domain within Multimeric von Willebrand Factor in Type 2 von Willebrand Disease. J Mol Biol. 2020 01 17; 432(2):305-323.J Mol Biol2019-10-17T00:00:002019Evidence for the Misfolding of the A1 Domain within Multimeric von Willebrand Factor in Type 2 von Willebrand Disease.true1ProfessorProfessorAuthorship 1139493DEREKMEEKSDEREK MEEKS0.000000000000000.000000000000005819MEEKS, DEREKAssociate Professortrue1Associate ProfessorAssociate Professor32259201Valladolid C, Martinez-Vargas M, Sekhar N, Lam F, Brown C, Palzkill T, Tischer A, Auton M, Vijayan KV, Rumbaut RE, Nguyen TC, Cruz MABlood advancesModulating the rate of fibrin formation and clot structure attenuates microvascular thrombosis in systemic inflammation. Blood Adv. 2020 04 14; 4(7):1340-1349.Blood Adv2020-04-14T00:00:002020Modulating the rate of fibrin formation and clot structure attenuates microvascular thrombosis in systemic inflammation.Authorship 98665012Authorship 991067532501489Mortus JR, Manek SE, Brubaker LS, Loor M, Cruz MA, Trautner BW, Rosengart TKJAMA network openThromboelastographic Results and Hypercoagulability Syndrome in Patients With Coronavirus Disease 2019 Who Are Critically Ill. JAMA Netw Open. 2020 06 01; 3(6):e2011192.JAMA Netw Open2020-06-01T00:00:002020Thromboelastographic Results and Hypercoagulability Syndrome in Patients With Coronavirus Disease 2019 Who Are Critically Ill.https://www.bcm.edu/research/centers/translational-research-inflammatory-diseasesCenter for Translational Research on Inflammatory DiseasesAuthorship 1002358332831332Trevi?o-Becerra A, Espinosa-Larra?aga F, Cruz M, Rodr?guez-P?rez MEGaceta medica de MexicoGaceta M?dica de M?xico in SARS-CoV-2 pandemic times. Gac Med Mex. 2020; 156(4):261-262.Gac Med Mex2020-01-01T00:00:002020Gaceta M?dica de M?xico in SARS-CoV-2 pandemic times.Authorship 1002749633048962Lam FW, Brown CA, Valladolid C, Emebo DC, Palzkill TG, Cruz MAPloS oneThe vimentin rod domain blocks P-selectin-P-selectin glycoprotein ligand 1 interactions to attenuate leukocyte adhesion to inflamed endothelium. PLoS One. 2020; 15(10):e0240164.PLoS One2020-10-13T00:00:002020The vimentin rod domain blocks P-selectin-P-selectin glycoprotein ligand 1 interactions to attenuate leukocyte adhesion to inflamed endothelium.Authorship 1005755333246792Brubaker L, Mortus J, Cruz M, Trautner B, Loor M, Rosengart TJournal of the American College of SurgeonsThromboelastography Might Be More Applicable to Guide Anticoagulant Therapy than Fibrinolytic Therapy in Critically Ill Patients with COVID-19. J Am Coll Surg. 2021 02; 232(2):227-229.J Am Coll Surg2020-11-25T00:00:002020Thromboelastography Might Be More Applicable to Guide Anticoagulant Therapy than Fibrinolytic Therapy in Critically Ill Patients with COVID-19.Authorship 1006584333290884Hubbard WB, Dong JF, Cruz MA, Rumbaut REThrombosis researchLinks between thrombosis and inflammation in traumatic brain injury. Thromb Res. 2021 02; 198:62-71.Thromb Res2020-11-25T00:00:002020Links between thrombosis and inflammation in traumatic brain injury.Authorship 10100351333507292Xu X, Wang C, Wu Y, Houck K, Hilton T, Zhou A, Wu X, Han C, Yang M, Yang W, Shi FD, Stolla M, Cruz MA, Li M, Zhang J, Dong JFBloodConformation-dependent blockage of activated VWF improves outcomes of traumatic brain injury in mice. Blood. 2021 01 28; 137(4):544-555.Blood2021-01-28T00:00:002021Conformation-dependent blockage of activated VWF improves outcomes of traumatic brain injury in mice.Authorship 101060910Authorship 1010714333539188Bashir DA, Da Q, Pradhan S, Sekhar N, Valladolid C, Lam F, Guffey D, Goldman J, Desai MS, Cruz MA, Allen C, Nguyen TC, Vijayan KVClinical and applied thrombosis/hemostasis : official journal of the International Academy of Clinical and Applied Thrombosis/HemostasisSecretion of von Willebrand Factor and Suppression of ADAMTS-13 Activity by Markedly High Concentration of Ferritin. Clin Appl Thromb Hemost. 2021 Jan-Dec; 27:1076029621992128.Clin Appl Thromb Hemost2021-01-01T00:00:002021Secretion of von Willebrand Factor and Suppression of ADAMTS-13 Activity by Markedly High Concentration of Ferritin.25601895Cahua-Pablo G, Cruz M, Moral-Hern?ndez OD, Leyva-V?zquez MA, Ant?nez-Ortiz DL, Cahua-Pablo JA, Alarc?n-Romero Ldel C, Ortu?o-Pineda C, Moreno-God?nez ME, Hern?ndez-Sotelo D, Flores-Alfaro EClinical and applied thrombosis/hemostasis : official journal of the International Academy of Clinical and Applied Thrombosis/HemostasisElevated Levels of LDL-C are Associated With ApoE4 but Not With the rs688 Polymorphism in the LDLR Gene. Clin Appl Thromb Hemost. 2016 Jul; 22(5):465-70.Clin Appl Thromb Hemost2015-01-19T00:00:002015Elevated Levels of LDL-C are Associated With ApoE4 but Not With the rs688 Polymorphism in the LDLR Gene.Authorship 1016101333839010Brubaker L, Mortus J, Cruz M, Trautner B, Loor M, Rosengart TJournal of the American College of SurgeonsThromboelastography MightBe More Applicable to Guide Anticoagulant Therapy than Fibrinolytic Therapy in Critically Ill Patients with COVID-19. J Am Coll Surg. 2021 06; 232(6):1021-1022.J Am Coll Surg2021-04-07T00:00:002021Thromboelastography MightBe More Applicable to Guide Anticoagulant Therapy than Fibrinolytic Therapy in Critically Ill Patients with COVID-19.Authorship 12202352025-04-30NIHCRUZ, MIGUEL ANGEL2021-06-01Molecular Studies of Hemolytic ThrombosisR01HL154688Principal InvestigatorAuthorship 1021370734141704Fang J, Sun X, Liu S, Yang P, Lin J, Feng J, Cruz MA, Dong JF, Fang Y, Wu JFrontiers in cell and developmental biologyShear Stress Accumulation Enhances von Willebrand Factor-Induced Platelet P-Selectin Translocation in a PI3K/Akt Pathway-Dependent Manner. Front Cell Dev Biol. 2021; 9:642108.Front Cell Dev Biol2021-06-01T00:00:002021Shear Stress Accumulation Enhances von Willebrand Factor-Induced Platelet P-Selectin Translocation in a PI3K/Akt Pathway-Dependent Manner.Authorship 10294141334506733Wu Y, Zeng Z, Guo Y, Song L, Weatherhead JE, Huang X, Zeng Y, Bimler L, Chang CY, Knight JM, Valladolid C, Sun H, Cruz MA, Hube B, Naglik JR, Luong AU, Kheradmand F, Corry DBImmunityCandida albicans elicits protective allergic responses via platelet mediated T helper 2 and T helper 17 cell polarization. Immunity. 2021 11 09; 54(11):2595-2610.e7.Immunity2021-09-09T00:00:002021Candida albicans elicits protective allergic responses via platelet mediated T helper 2 and T helper 17 cell polarization.Authorship 1193394Authorship 1037736935170535Brubaker LS, Saini A, Nguyen TC, Martinez-Vargas M, Lam FW, Yao Q, Loor MM, Rosengart TK, Cruz MACritical care medicineAberrant Fibrin Clot Structure Visualized Ex Vivo in Critically Ill Patients With Severe Acute Respiratory Syndrome Coronavirus 2 Infection. Crit Care Med. 2022 06 01; 50(6):e557-e568.Crit Care Med2022-02-16T00:00:002022Aberrant Fibrin Clot Structure Visualized Ex Vivo in Critically Ill Patients With Severe Acute Respiratory Syndrome Coronavirus 2 Infection.Authorship 10437421035411318Yang M, Houck KL, Dong X, Hernandez M, Wang Y, Nathan SS, Wu X, Afshar-Kharghan V, Fu X, Cruz MA, Zhang J, Nascimbene A, Dong JFJACC. Basic to translational scienceHyperadhesive von Willebrand Factor Promotes Extracellular Vesicle-Induced Angiogenesis: Implication for LVAD-Induced Bleeding. JACC Basic Transl Sci. 2022 Mar; 7(3):247-261.JACC Basic Transl Sci2022-03-28T00:00:002022Hyperadhesive von Willebrand Factor Promotes Extracellular Vesicle-Induced Angiogenesis: Implication for LVAD-Induced Bleeding.Authorship 1366166Authorship 1366563Authorship 137054324030386Chan HC, Ke LY, Chu CS, Lee AS, Shen MY, Cruz MA, Hsu JF, Cheng KH, Chan HC, Lu J, Lai WT, Sawamura T, Sheu SH, Yen JH, Chen CHBloodHighly electronegative LDL from patients with ST-elevation myocardial infarction triggers platelet activation and aggregation. Blood. 2013 Nov 21; 122(22):3632-41.Blood2013-09-12T00:00:002013Highly electronegative LDL from patients with ST-elevation myocardial infarction triggers platelet activation and aggregation.24062306Ju L, Dong JF, Cruz MA, Zhu CThe Journal of biological chemistryThe N-terminal flanking region of the A1 domain regulates the force-dependent binding of von Willebrand factor to platelet glycoprotein Iba. J Biol Chem. 2013 Nov 08; 288(45):32289-32301.J Biol Chem2013-09-23T00:00:002013The N-terminal flanking region of the A1 domain regulates the force-dependent binding of von Willebrand factor to platelet glycoprotein Iba.24097977Lo NC, Turner NA, Cruz MA, Moake JThe Journal of biological chemistryInteraction of Shiga toxin with the A-domains and multimers of von Willebrand Factor. J Biol Chem. 2013 Nov 15; 288(46):33118-23.J Biol Chem2013-10-04T00:00:002013Interaction of Shiga toxin with the A-domains and multimers of von Willebrand Factor.Authorship 104584928535551307Mahajan A, Spracklen CN, Zhang W, Ng MCY, Petty LE, Kitajima H, Yu GZ, R?eger S, Speidel L, Kim YJ, Horikoshi M, Mercader JM, Taliun D, Moon S, Kwak SH, Robertson NR, Rayner NW, Loh M, Kim BJ, Chiou J, Miguel-Escalada I, Della Briotta Parolo P, Lin K, Bragg F, Preuss MH, Takeuchi F, Nano J, Guo X, Lamri A, Nakatochi M, Scott RA, Lee JJ, Huerta-Chagoya A, Graff M, Chai JF, Parra EJ, Yao J, Bielak LF, Tabara Y, Hai Y, Steinthorsdottir V, Cook JP, Kals M, Grarup N, Schmidt EM, Pan I, Sofer T, Wuttke M, Sarnowski C, Gieger C, Nousome D, Trompet S, Long J, Sun M, Tong L, Chen WM, Ahmad M, Noordam R, Lim VJY, Tam CHT, Joo YY, Chen CH, Raffield LM, Lecoeur C, Prins BP, Nicolas A, Yanek LR, Chen G, Jensen RA, Tajuddin S, Kabagambe EK, An P, Xiang AH, Choi HS, Cade BE, Tan J, Flanagan J, Abaitua F, Adair LS, Adeyemo A, Aguilar-Salinas CA, Akiyama M, Anand SS, Bertoni A, Bian Z, Bork-Jensen J, Brandslund I, Brody JA, Brummett CM, Buchanan TA, Canouil M, Chan JCN, Chang LC, Chee ML, Chen J, Chen SH, Chen YT, Chen Z, Chuang LM, Cushman M, Das SK, de Silva HJ, Dedoussis G, Dimitrov L, Doumatey AP, Du S, Duan Q, Eckardt KU, Emery LS, Evans DS, Evans MK, Fischer K, Floyd JS, Ford I, Fornage M, Franco OH, Frayling TM, Freedman BI, Fuchsberger C, Genter P, Gerstein HC, Giedraitis V, Gonz?lez-Villalpando C, Gonz?lez-Villalpando ME, Goodarzi MO, Gordon-Larsen P, Gorkin D, Gross M, Guo Y, Hackinger S, Han S, Hattersley AT, Herder C, Howard AG, Hsueh W, Huang M, Huang W, Hung YJ, Hwang MY, Hwu CM, Ichihara S, Ikram MA, Ingelsson M, Islam MT, Isono M, Jang HM, Jasmine F, Jiang G, Jonas JB, J?rgensen ME, J?rgensen T, Kamatani Y, Kandeel FR, Kasturiratne A, Katsuya T, Kaur V, Kawaguchi T, Keaton JM, Kho AN, Khor CC, Kibriya MG, Kim DH, Kohara K, Kriebel J, Kronenberg F, Kuusisto J, L?ll K, Lange LA, Lee MS, Lee NR, Leong A, Li L, Li Y, Li-Gao R, Ligthart S, Lindgren CM, Linneberg A, Liu CT, Liu J, Locke AE, Louie T, Luan J, Luk AO, Luo X, Lv J, Lyssenko V, Mamakou V, Mani KR, Meitinger T, Metspalu A, Morris AD, Nadkarni GN, Nadler JL, Nalls MA, Nayak U, Nongmaithem SS, Ntalla I, Okada Y, Orozco L, Patel SR, Pereira MA, Peters A, Pirie FJ, Porneala B, Prasad G, Preissl S, Rasmussen-Torvik LJ, Reiner AP, Roden M, Rohde R, Roll K, Sabanayagam C, Sander M, Sandow K, Sattar N, Sch?nherr S, Schurmann C, Shahriar M, Shi J, Shin DM, Shriner D, Smith JA, So WY, Stanc?kov? A, Stilp AM, Strauch K, Suzuki K, Takahashi A, Taylor KD, Thorand B, Thorleifsson G, Thorsteinsdottir U, Tomlinson B, Torres JM, Tsai FJ, Tuomilehto J, Tusie-Luna T, Udler MS, Valladares-Salgado A, van Dam RM, van Klinken JB, Varma R, Vujkovic M, Wacher-Rodarte N, Wheeler E, Whitsel EA, Wickremasinghe AR, van Dijk KW, Witte DR, Yajnik CS, Yamamoto K, Yamauchi T, Yengo L, Yoon K, Yu C, Yuan JM, Yusuf S, Zhang L, Zheng W, FinnGen, eMERGE Consortium, Raffel LJ, Igase M, Ipp E, Redline S, Cho YS, Lind L, Province MA, Hanis CL, Peyser PA, Ingelsson E, Zonderman AB, Psaty BM, Wang YX, Rotimi CN, Becker DM, Matsuda F, Liu Y, Zeggini E, Yokota M, Rich SS, Kooperberg C, Pankow JS, Engert JC, Chen YI, Froguel P, Wilson JG, Sheu WHH, Kardia SLR, Wu JY, Hayes MG, Ma RCW, Wong TY, Groop L, Mook-Kanamori DO, Chandak GR, Collins FS, Bharadwaj D, Par? G, Sale MM, Ahsan H, Motala AA, Shu XO, Park KS, Jukema JW, Cruz M, McKean-Cowdin R, Grallert H, Cheng CY, Bottinger EP, Dehghan A, Tai ES, Dupuis J, Kato N, Laakso M, K?ttgen A, Koh WP, Palmer CNA, Liu S, Abecasis G, Kooner JS, Loos RJF, North KE, Haiman CA, Florez JC, Saleheen D, Hansen T, Pedersen O, M?gi R, Langenberg C, Wareham NJ, Maeda S, Kadowaki T, Lee J, Millwood IY, Walters RG, Stefansson K, Myers SR, Ferrer J, Gaulton KJ, Meigs JB, Mohlke KL, Gloyn AL, Bowden DW, Below JE, Chambers JC, Sim X, Boehnke M, Rotter JI, McCarthy MI, Morris APNature geneticsMulti-ancestry genetic study of type 2 diabetes highlights the power of diverse populations for discovery and translation. Nat Genet. 2022 05; 54(5):560-572.Nat Genet2022-05-12T00:00:002022Multi-ancestry genetic study of type 2 diabetes highlights the power of diverse populations for discovery and translation.https://www.bcm.edu/people-search/fong-lam-25023Baylor College of MedicineAuthorship 1051265535881214Bray M, Guzel MA, Lam F, Yee A, Cruz MA, Rumbaut REJournal of thrombosis and thrombolysisHigh levels of von Willebrand factor with reduced specific activities in hospitalized patients with or without COVID-19. J Thromb Thrombolysis. 2022 Aug; 54(2):211-216.J Thromb Thrombolysis2022-07-26T00:00:002022High levels of von Willebrand factor with reduced specific activities in hospitalized patients with or without COVID-19.true1ProfessorProfessor2ProfessorProfessortrue1Associate ProfessorAssociate ProfessorAuthorship 10604891036495717Martinez-Vargas M, Cebula A, Brubaker LS, Seshadri N, Lam FW, Loor M, Rosengart TK, Yee A, Rumbaut RE, Cruz MAThrombosis researchA novel interaction between extracellular vimentin and fibrinogen in fibrin formation. Thromb Res. 2023 01; 221:97-104.Thromb Res2022-12-07T00:00:002022A novel interaction between extracellular vimentin and fibrinogen in fibrin formation.true1Adjunct ProfessorAdjunct Professortrue1Professor EmeritusProfessor Emeritustrue1Adjunct ProfessorAdjunct Professor37255626Nguyen TC, Marini JC, Guillory B, Valladolid-Brown C, Martinez-Vargas M, Subramanyam D, Cohen D, Cirlos SC, Lam F, Stoll B, Didelija IC, Vonderohe C, Orellana R, Saini A, Pradhan S, Bashir D, Desai MS, Flores S, Virk M, Tcharmtchi H, Navaei A, Kaplan S, Lamberth L, Hulten KG, Scull BP, Allen CE, Akcan-Arikan A, Vijayan KV, Cruz MACritical care explorationsPediatric Swine Model of Methicillin-Resistant Staphylococcus aureus Sepsis-Induced Coagulopathy, Disseminated Microvascular Thrombosis, and Organ Injuries. Crit Care Explor. 2023 Jun; 5(6):e0916.Crit Care Explor2023-05-26T00:00:002023Pediatric Swine Model of Methicillin-Resistant Staphylococcus aureus Sepsis-Induced Coagulopathy, Disseminated Microvascular Thrombosis, and Organ Injuries.Authorship 10721006Authorship 10725282937421684Lin J, Ding X, Yang P, Liu S, Li Q, Cruz MA, Dong JF, Fang Y, Wu JThrombosis researchForce-induced biphasic regulation of VWF cleavage by ADAMTS13. Thromb Res. 2023 09; 229:99-106.Thromb Res2023-07-01T00:00:002023Force-induced biphasic regulation of VWF cleavage by ADAMTS13.true1InstructorInstructorAuthorship 157796true1Clinical Associate ProfessorClinical Associate ProfessorAuthorship 182325Authorship 210131Authorship 212883Authorship 303916Authorship 25081Authorship 358823Authorship 29674Authorship 301266Authorship 142636524642750Da Q, Behymer M, Correa JI, Vijayan KV, Cruz MABloodPlatelet adhesion involves a novel interaction between vimentin and von Willebrand factor under high shear stress. Blood. 2014 Apr 24; 123(17):2715-21.Blood2014-03-18T00:00:002014Platelet adhesion involves a novel interaction between vimentin and von Willebrand factor under high shear stress.Authorship 507592Authorship 516313Authorship 531067Authorship 46303Authorship 658922Authorship 546057Authorship 797512Authorship 615734Authorship 986711Authorship 720662Authorship 787294Authorship 79711