MARYESTESMARY ESTES0.000000000000000.000000000000002318ESTES, MARYMolecular Biology of Gastrointestinal Viruses
The gastrointestinal (GI) tract represents the largest and most heterogeneous organ in the body. However, information on the molecular biology of most cell types in the GI tract remains limited. We are using viruses that infect distinct types of cells (enterocytes, crypt cells, M cells) in the GI tract as probes to learn about the biology, host response and gene expression of these cells. We are using multidisciplinary approaches to probe the structure and molecular biology of GI viruses to understand the basic mechanisms that control virus replication, morphogenesis, virus-host interactions, and pathogenesis.
Our work uses two viruses, rotaviruses, the major cause of diarrhea in children and animals worldwide, and human caliciviruses, the major cause of epidemic gastroenteritis. Studies on the molecular biology of the rotaviruses seek to dissect the biologic, biochemical and structural role(s) inducing disease. Current studies are focusing on the rotavirus spike protein and the viral enterotoxin and how these proteins induce signaling pathways in cells that are important in immunity and pathogenesis. We are studying proteins expressed from inducible cDNAs in mammalian cells and virus-like particles (VLPs) produced using the baculovirus expression system. We aim to determine how specific domains of the viral proteins interact with intestinal cell receptors, affect cell signaling mechan-isms, and induce diarrhea. We also are evaluating how to effectively orally deliver virus-like particlesubunit vaccines to induce a mucosal immune response and protection from virus infection.
Studies on the human caliciviruses are using molecular approaches to characterize Norwalk virus and related viruses. Sequence analysis and expression of genes from a cloned DNA library of Norwalk virus nucleic acid have classified this virus, determined its genome organization and relatedness to other Norwalk-like viruses and other gastroenteritis viruses such as astroviruses and enteroviruses, and produced new diagnostic assays. Use of these new assays is changing our understanding of the natural history and epidemiology of infections with these viruses. Notably, these viruses are being increasingly recognized as important causes of disease in children and in immunocompromised individuals. Expression of the capsid protein using mammalian and plant VLPs allowed the first crystallographic structure of a calicivirus to be solved and they are being tested directly as mucosal vaccines or as delivery systems for vaccines containing epitopes from other pathogens. Finally, the molecular basis of the restricted replication of Norwalk viruses to the gastrointestinal tract of humans is being probed by expression of Norwalk virus genes with different vectors and testing the interactions of virus with different cell lines and tissues derived from the gastrointestinal tract.Distinguished Service Professorprns:coAuthorOfcoauthor ofprns:emailEncryptedemail addressprns:endDateend dateFaculty Rankprns:fullNamefull nameprns:grantAwardedBygrant awarded byprns:hasAuthorListauthor listprns:hasFacultyRankhas faculty rankprns:hasNetworkhas networkprns:hasPublicationVenuepublished inprns:informationResourceReferenceinformation resource referenceprns:isPrimaryPositionis primary positionprns:latitudelatitudeprns:longitudelongitudeprns:mainImagephotoprns:maxWeightmaximum weightprns:medlineTAjournal title abbreviationprns:meshDescriptorUIMeSH DescriptorUIprns:meshSemanticGroupNameMeSH semantic group nameprns:minWeightminimum weightprns:numberOfAuthorsnumber of authorsprns:numberOfConnectionsnumber of connectionsprns:numberOfPublicationsnumber of publicationsprns:personIdPerson IDprns:personInPrimaryPositionperson in primary positionprns:physicalNeighborOfphysical neighborprns:positionInDepartmentposition in departmentprns:positionInDivisionposition in divisionprns:predicateNodepredicate nodeprns:principalInvestigatorNameprincipal investigator nameprns:publicationDatepublication dateprns:similarTosimilar toprns:sortOrdersort orderprns:startDatestart dateprns:uniquenessWeightuniqueness weightprns:yearyearAcademic ArticleArticleDocumentbibo:pmidPubMed IdentifierAddressvivo:address1address line 1vivo:addressCitycityvivo:addressPostalCodepostal codevivo:addressStatestate or provinceAgreementvivo:authorInAuthorshipselected publicationsvivo:authorRankauthor rank in publicationAuthorshipvivo:awardOrHonorawards and honorsAward or Honor ReceiptDepartmentDivisionGrantvivo:hasResearchArearesearch areasvivo:hasResearcherRoleresearch activitiesvivo:hrJobTitleHR job titleInformation Resourcevivo:linkedAuthorlinked authorvivo:linkedInformationResourcelinked information resourcevivo:mailingAddressmailing addressvivo:overviewoverviewvivo:personInPositionpositionsPositionvivo:positionInOrganizationposition in organizationvivo:preferredTitlepreferred titleResearcher Rolevivo:researcherRoleOfresearcher role ofRolevivo:roleContributesTocontributes tovivo:sponsorAwardIdsponsor award idrdf:predicatepredicaterdf:typetyperdfs:labellabelConceptAgentfoaf:firstNamefirst namefoaf:lastNamelast nameOrganizationPersonAuthorship 1563431025015947Atmar RL, Opekun AR, Estes MK, Graham DYThe Journal of infectious diseasesReply to Kirby et al. J Infect Dis. 2015 Jan 01; 211(1):167.J Infect Dis2014-07-10T00:00:002014Reply to Kirby et al.25395539Zhang B, Chassaing B, Shi Z, Uchiyama R, Zhang Z, Denning TL, Crawford SE, Pruijssers AJ, Iskarpatyoti JA, Estes MK, Dermody TS, Ouyang W, Williams IR, Vijay-Kumar M, Gewirtz ATScience (New York, N.Y.)Viral infection. Prevention and cure of rotavirus infection via TLR5/NLRC4-mediated production of IL-22 and IL-18. Science. 2014 Nov 14; 346(6211):861-5.Science2014-11-14T00:00:002014Viral infection. Prevention and cure of rotavirus infection via TLR5/NLRC4-mediated production of IL-22 and IL-18.Authorship 830123Authorship 834912Authorship 854285Authorship 882975Authorship 88633223687584Koo HL, Neill FH, Estes MK, Munoz FM, Cameron A, DuPont HL, Atmar RLJournal of the Pediatric Infectious Diseases SocietyNoroviruses: The Most Common Pediatric Viral Enteric Pathogen at a Large University Hospital After Introduction of Rotavirus Vaccination. J Pediatric Infect Dis Soc. 2013 Mar; 2(1):57-60.J Pediatric Infect Dis Soc2012-08-03T00:00:002012Noroviruses: The Most Common Pediatric Viral Enteric Pathogen at a Large University Hospital After Introduction of Rotavirus Vaccination.Authorship 942615Authorship 9814911Authorship 986734Authorship 968234Authorship 1026844Authorship 1087144Authorship 1089764Authorship 1125126Authorship 1139987Authorship 1157895Authorship 149224Authorship 15145Authorship 178957Authorship 202054Authorship 233013Authorship 16057010Authorship 1623038Authorship 1623795Authorship 1624271325210140Bernstein DI, Atmar RL, Lyon GM, Treanor JJ, Chen WH, Jiang X, Vinj? J, Gregoricus N, Frenck RW, Moe CL, Al-Ibrahim MS, Barrett J, Ferreira J, Estes MK, Graham DY, Goodwin R, Borkowski A, Clemens R, Mendelman PMThe Journal of infectious diseasesNorovirus vaccine against experimental human GII.4 virus illness: a challenge study in healthy adults. J Infect Dis. 2015 Mar 15; 211(6):870-8.J Infect Dis2014-09-09T00:00:002014Norovirus vaccine against experimental human GII.4 virus illness: a challenge study in healthy adults.25428246Crawford SE, Ajami N, Parker TD, Kitamoto N, Natori K, Takeda N, Tanaka T, Kou B, Atmar RL, Estes MKClinical and vaccine immunology : CVIMapping broadly reactive norovirus genogroup I and II monoclonal antibodies. Clin Vaccine Immunol. 2015 Feb; 22(2):168-77.Clin Vaccine Immunol2014-11-26T00:00:002014Mapping broadly reactive norovirus genogroup I and II monoclonal antibodies.25428247Kou B, Crawford SE, Ajami NJ, Czak? R, Neill FH, Tanaka TN, Kitamoto N, Palzkill TG, Estes MK, Atmar RLClinical and vaccine immunology : CVICharacterization of cross-reactive norovirus-specific monoclonal antibodies. Clin Vaccine Immunol. 2015 Feb; 22(2):160-7.Clin Vaccine Immunol2014-11-26T00:00:002014Characterization of cross-reactive norovirus-specific monoclonal antibodies.25540269Czak? R, Atmar RL, Opekun AR, Gilger MA, Graham DY, Estes MKClinical and vaccine immunology : CVIExperimental human infection with Norwalk virus elicits a surrogate neutralizing antibody response with cross-genogroup activity. Clin Vaccine Immunol. 2015 Feb; 22(2):221-8.Clin Vaccine Immunol2014-12-24T00:00:002014Experimental human infection with Norwalk virus elicits a surrogate neutralizing antibody response with cross-genogroup activity.Authorship 400234Authorship 489525Authorship 262080525978622Hagstr?m AE, Garvey G, Paterson AS, Dhamane S, Adhikari M, Estes MK, Strych U, Kourentzi K, Atmar RL, Willson RCPloS oneSensitive detection of norovirus using phage nanoparticle reporters in lateral-flow assay. PLoS One. 2015; 10(5):e0126571.PLoS One2015-05-15T00:00:002015Sensitive detection of norovirus using phage nanoparticle reporters in lateral-flow assay.Authorship 534417Authorship 584956Authorship 615525Authorship 624818Authorship 655283Authorship 717978Authorship 761763Authorship 811703Authorship 895511Authorship 895744Authorship 912138Authorship 960415Authorship 98130419671966Beta Beta Beta1967Biology Award, Elmira College1974American Cancer Society Postdoctoral Fellowship (declined)19761974National Institutes of Health Postdoctoral Fellowship19881987ASM Foundation for Microbiology, Lecturer in Virology1992Wallace P. Rowe Award for Excellence in Virologic Research19941992ASM Foundation for Microbiology, Lecturer in Virology20031994Editor, Journal of Virology19951995 Michael E. DeBakey Award for Outstanding Research19961996 Elected Fellow, American Academy of Microbiology19971996President, American Society for Virology20002000 Elected Fellow, American Association for the Advancement of Science2000Researcher/Investigator of the Year, Crohn’s & Colitis Foundation Gold Key Award2005Elected Member, Institute of Medicine, National Academy of Science2005Member, Academy of Medicine, Engineering and Science of Texas2006Cullen Foundation Endowed Chair of Human and Molecular Virology2007Elected Member, National Academy of Sciences2007Associate Editor, PLoS Pathogens2009Distinguished Faculty Award, Baylor College of Medicine2009mBio Board of Editors2010Distinguished Service Professor, Baylor College of Medicine2010AGA Distinguished Achievement Award 20132011Co-Editor in Chief, Current Opinion in Virology2011Elected Fellow, American Gastroenterological AssociationAuthorship 2870943Authorship 2939356Authorship 2992625Authorship 3006978Authorship 30084519Authorship 3037772Authorship 3052191525635121Ramani S, Neill FH, Opekun AR, Gilger MA, Graham DY, Estes MK, Atmar RLThe Journal of infectious diseasesMucosal and Cellular Immune Responses to Norwalk Virus. J Infect Dis. 2015 Aug 01; 212(3):397-405.J Infect Dis2015-01-29T00:00:002015Mucosal and Cellular Immune Responses to Norwalk Virus.26021234Henning SJ, Estes MKGastroenterologyWomen in Science: Hints for Success. Gastroenterology. 2015 Jul; 149(1):10-3.Gastroenterology2015-05-27T00:00:002015Women in Science: Hints for Success.26041041Atmar RL, Bernstein DI, Lyon GM, Treanor JJ, Al-Ibrahim MS, Graham DY, Vinj? J, Jiang X, Gregoricus N, Frenck RW, Moe CL, Chen WH, Ferreira J, Barrett J, Opekun AR, Estes MK, Borkowski A, Baehner F, Goodwin R, Edmonds A, Mendelman PMClinical and vaccine immunology : CVISerological Correlates of Protection against a GII.4 Norovirus. Clin Vaccine Immunol. 2015 Aug; 22(8):923-9.Clin Vaccine Immunol2015-06-03T00:00:002015Serological Correlates of Protection against a GII.4 Norovirus.26420502Hu L, Ramani S, Czako R, Sankaran B, Yu Y, Smith DF, Cummings RD, Estes MK, Venkataram Prasad BVNature communicationsStructural basis of glycan specificity in neonate-specific bovine-human reassortant rotavirus. Nat Commun. 2015 Sep 30; 6:8346.Nat Commun2015-09-30T00:00:002015Structural basis of glycan specificity in neonate-specific bovine-human reassortant rotavirus.26446608Saxena K, Blutt SE, Ettayebi K, Zeng XL, Broughman JR, Crawford SE, Karandikar UC, Sastri NP, Conner ME, Opekun AR, Graham DY, Qureshi W, Sherman V, Foulke-Abel J, In J, Kovbasnjuk O, Zachos NC, Donowitz M, Estes MKJournal of virologyHuman Intestinal Enteroids: a New Model To Study Human Rotavirus Infection, Host Restriction, and Pathophysiology. J Virol. 2016 01 01; 90(1):43-56.J Virol2015-10-07T00:00:002015Human Intestinal Enteroids: a New Model To Study Human Rotavirus Infection, Host Restriction, and Pathophysiology.26447115Kou B, Huang W, Neill FH, Palzkill T, Estes MK, Atmar RLJournal of clinical microbiologyNorovirus Antigen Detection with a Combination of Monoclonal and Single-Chain Antibodies. J Clin Microbiol. 2015 Dec; 53(12):3916-8.J Clin Microbiol2015-10-07T00:00:002015Norovirus Antigen Detection with a Combination of Monoclonal and Single-Chain Antibodies.One Baylor PlazaHouston, 77030TX12001052Hutson AM, Atmar RL, Graham DY, Estes MKThe Journal of infectious diseasesNorwalk virus infection and disease is associated with ABO histo-blood group type. J Infect Dis. 2002 May 01; 185(9):1335-7.J Infect Dis2002-04-16T00:00:002002Norwalk virus infection and disease is associated with ABO histo-blood group type.14499247Tacket CO, Sztein MB, Losonsky GA, Wasserman SS, Estes MKClinical immunology (Orlando, Fla.)Humoral, mucosal, and cellular immune responses to oral Norwalk virus-like particles in volunteers. Clin Immunol. 2003 Sep; 108(3):241-7.Clin Immunol2003-09-01T00:00:002003Humoral, mucosal, and cellular immune responses to oral Norwalk virus-like particles in volunteers.15165606Hutson AM, Atmar RL, Estes MKTrends in microbiologyNorovirus disease: changing epidemiology and host susceptibility factors. Trends Microbiol. 2004 Jun; 12(6):279-87.Trends Microbiol2004-06-01T00:00:002004Norovirus disease: changing epidemiology and host susceptibility factors.11907248Ciarlet M, Ludert JE, Iturriza-G?mara M, Liprandi F, Gray JJ, Desselberger U, Estes MKJournal of virologyInitial interaction of rotavirus strains with N-acetylneuraminic (sialic) acid residues on the cell surface correlates with VP4 genotype, not species of origin. J Virol. 2002 Apr; 76(8):4087-95.J Virol2002-04-01T00:00:002002Initial interaction of rotavirus strains with N-acetylneuraminic (sialic) acid residues on the cell surface correlates with VP4 genotype, not species of origin.15596848Chakravarty S, Hutson AM, Estes MK, Prasad BVJournal of virologyEvolutionary trace residues in noroviruses: importance in receptor binding, antigenicity, virion assembly, and strain diversity. J Virol. 2005 Jan; 79(1):554-68.J Virol2005-01-01T00:00:002005Evolutionary trace residues in noroviruses: importance in receptor binding, antigenicity, virion assembly, and strain diversity.74Professor10Assistant Professor5Adjunct Instructor14Associate Professor78Professor Emeritus47Distinguished Service Professor15845507Nurgalieva ZZ, Conner ME, Opekun AR, Zheng CQ, Elliott SN, Ernst PB, Osato M, Estes MK, Graham DYInfection and immunityB-cell and T-cell immune responses to experimental Helicobacter pylori infection in humans. Infect Immun. 2005 May; 73(5):2999-3006.Infect Immun2005-05-01T00:00:002005B-cell and T-cell immune responses to experimental Helicobacter pylori infection in humans.15956598Pesavento JB, Crawford SE, Roberts E, Estes MK, Prasad BVJournal of virologypH-induced conformational change of the rotavirus VP4 spike: implications for cell entry and antibody neutralization. J Virol. 2005 Jul; 79(13):8572-80.J Virol2005-07-01T00:00:002005pH-induced conformational change of the rotavirus VP4 spike: implications for cell entry and antibody neutralization.16002473Asanaka M, Atmar RL, Ruvolo V, Crawford SE, Neill FH, Estes MKProceedings of the National Academy of Sciences of the United States of AmericaReplication and packaging of Norwalk virus RNA in cultured mammalian cells. Proc Natl Acad Sci U S A. 2005 Jul 19; 102(29):10327-32.Proc Natl Acad Sci U S A2005-07-07T00:00:002005Replication and packaging of Norwalk virus RNA in cultured mammalian cells.11773387Ciarlet M, Crawford SE, Cheng E, Blutt SE, Rice DA, Bergelson JM, Estes MKJournal of virologyVLA-2 (alpha2beta1) integrin promotes rotavirus entry into cells but is not necessary for rotavirus attachment. J Virol. 2002 Feb; 76(3):1109-23.J Virol2002-02-01T00:00:002002VLA-2 (alpha2beta1) integrin promotes rotavirus entry into cells but is not necessary for rotavirus attachment.16210477Vizzi E, Calvi?o E, Gonz?lez R, P?rez-Schael I, Ciarlet M, Kang G, Estes MK, Liprandi F, Ludert JEClinical and diagnostic laboratory immunologyEvaluation of serum antibody responses against the rotavirus nonstructural protein NSP4 in children after rhesus rotavirus tetravalent vaccination or natural infection. Clin Diagn Lab Immunol. 2005 Oct; 12(10):1157-63.Clin Diagn Lab Immunol2005-10-01T00:00:002005Evaluation of serum antibody responses against the rotavirus nonstructural protein NSP4 in children after rhesus rotavirus tetravalent vaccination or natural infection.12089262Kitamoto N, Tanaka T, Natori K, Takeda N, Nakata S, Jiang X, Estes MKJournal of clinical microbiologyCross-reactivity among several recombinant calicivirus virus-like particles (VLPs) with monoclonal antibodies obtained from mice immunized orally with one type of VLP. J Clin Microbiol. 2002 Jul; 40(7):2459-65.J Clin Microbiol2002-07-01T00:00:002002Cross-reactivity among several recombinant calicivirus virus-like particles (VLPs) with monoclonal antibodies obtained from mice immunized orally with one type of VLP.12093168Casola A, Garofalo RP, Crawford SE, Estes MK, Mercurio F, Crowe SE, Brasier ARVirologyInterleukin-8 gene regulation in intestinal epithelial cells infected with rotavirus: role of viral-induced IkappaB kinase activation. Virology. 2002 Jun 20; 298(1):8-19.Virology2002-06-20T00:00:002002Interleukin-8 gene regulation in intestinal epithelial cells infected with rotavirus: role of viral-induced IkappaB kinase activation.Authorship 3202826Authorship 3213533Authorship 3213897Authorship 3218862Authorship 3227472Authorship 32290713Authorship 323712626656120Hesse S, Neill FH, Estes MK, Shanker S, Prasad BV, Ferreira J, Atmar RLClinical and vaccine immunology : CVISerological Responses to a Norovirus Nonstructural Fusion Protein after Vaccination and Infection. Clin Vaccine Immunol. 2016 02; 23(2):181-3.Clin Vaccine Immunol2015-12-09T00:00:002015Serological Responses to a Norovirus Nonstructural Fusion Protein after Vaccination and Infection.26677228Zachos NC, Kovbasnjuk O, Foulke-Abel J, In J, Blutt SE, de Jonge HR, Estes MK, Donowitz MThe Journal of biological chemistryHuman Enteroids/Colonoids and Intestinal Organoids Functionally Recapitulate Normal Intestinal Physiology and Pathophysiology. J Biol Chem. 2016 Feb 19; 291(8):3759-66.J Biol Chem2015-12-16T00:00:002015Human Enteroids/Colonoids and Intestinal Organoids Functionally Recapitulate Normal Intestinal Physiology and Pathophysiology.26677983Foulke-Abel J, In J, Yin J, Zachos NC, Kovbasnjuk O, Estes MK, de Jonge H, Donowitz MGastroenterologyHuman Enteroids as a Model of Upper Small Intestinal Ion Transport Physiology and Pathophysiology. Gastroenterology. 2016 Mar; 150(3):638-649.e8.Gastroenterology2015-12-08T00:00:002015Human Enteroids as a Model of Upper Small Intestinal Ion Transport Physiology and Pathophysiology.26958925Hyser JM, Estes MKAnnual review of virologyPathophysiological Consequences of Calcium-Conducting Viroporins. Annu Rev Virol. 2015 Nov; 2(1):473-96.Annu Rev Virol2015-11-01T00:00:002015Pathophysiological Consequences of Calcium-Conducting Viroporins.27115358Ramani S, Estes MK, Atmar RLPLoS pathogensCorrelates of Protection against Norovirus Infection and Disease-Where Are We Now, Where Do We Go? PLoS Pathog. 2016 04; 12(4):e1005334.PLoS Pathog2016-04-26T00:00:002016Correlates of Protection against Norovirus Infection and Disease-Where Are We Now, Where Do We Go?27284939Menon VK, George S, Sarkar R, Giri S, Samuel P, Vivek R, Saravanabavan A, Liakath FB, Ramani S, Iturriza-Gomara M, Gray JJ, Brown DW, Estes MK, Kang GPloS oneNorovirus Gastroenteritis in a Birth Cohort in Southern India. PLoS One. 2016; 11(6):e0157007.PLoS One2016-06-10T00:00:002016Norovirus Gastroenteritis in a Birth Cohort in Southern India.27355511Sapparapu G, Czak? R, Alvarado G, Shanker S, Prasad BV, Atmar RL, Estes MK, Crowe JEPLoS pathogensFrequent Use of the IgA Isotype in Human B Cells Encoding Potent Norovirus-Specific Monoclonal Antibodies That Block HBGA Binding. PLoS Pathog. 2016 06; 12(6):e1005719.PLoS Pathog2016-06-29T00:00:002016Frequent Use of the IgA Isotype in Human B Cells Encoding Potent Norovirus-Specific Monoclonal Antibodies That Block HBGA Binding.16702551Chen R, Neill JD, Estes MK, Prasad BVProceedings of the National Academy of Sciences of the United States of AmericaX-ray structure of a native calicivirus: structural insights into antigenic diversity and host specificity. Proc Natl Acad Sci U S A. 2006 May 23; 103(21):8048-53.Proc Natl Acad Sci U S A2006-05-15T00:00:002006X-ray structure of a native calicivirus: structural insights into antigenic diversity and host specificity.14557646Bertolotti-Ciarlet A, Crawford SE, Hutson AM, Estes MKJournal of virologyThe 3' end of Norwalk virus mRNA contains determinants that regulate the expression and stability of the viral capsid protein VP1: a novel function for the VP2 protein. J Virol. 2003 Nov; 77(21):11603-15.J Virol2003-11-01T00:00:002003The 3' end of Norwalk virus mRNA contains determinants that regulate the expression and stability of the viral capsid protein VP1: a novel function for the VP2 protein.Authorship 3252466Authorship 325626327318434Prasad BV, Shanker S, Muhaxhiri Z, Deng L, Choi JM, Estes MK, Song Y, Palzkill T, Atmar RLCurrent opinion in virologyAntiviral targets of human noroviruses. Curr Opin Virol. 2016 06; 18:117-25.Curr Opin Virol2016-06-17T00:00:002016Antiviral targets of human noroviruses.27495982Hesse S, Neill FH, Estes MK, Shanker S, Prasad BV, Ferreira J, Atmar RLClinical and vaccine immunology : CVICorrection for Hesse et al., Serological Responses to a Norovirus Nonstructural Fusion Protein after Vaccination and Infection. Clin Vaccine Immunol. 2016 08; 23(8):735.Clin Vaccine Immunol2016-08-05T00:00:002016Correction for Hesse et al., Serological Responses to a Norovirus Nonstructural Fusion Protein after Vaccination and Infection.12477845Hutson AM, Atmar RL, Marcus DM, Estes MKJournal of virologyNorwalk virus-like particle hemagglutination by binding to h histo-blood group antigens. J Virol. 2003 Jan; 77(1):405-15.J Virol2003-01-01T00:00:002003Norwalk virus-like particle hemagglutination by binding to h histo-blood group antigens.14718622Duizer E, Schwab KJ, Neill FH, Atmar RL, Koopmans MPG, Estes MKThe Journal of general virologyLaboratory efforts to cultivate noroviruses. J Gen Virol. 2004 Jan; 85(Pt 1):79-87.J Gen Virol2004-01-01T00:00:002004Laboratory efforts to cultivate noroviruses.Authorship 3267448Authorship 3268268Authorship 326904227254033Ramani S, Mamani N, Villena R, Bandyopadhyay AS, Gast C, Sato A, Laucirica D, Clemens R, Estes MK, O'Ryan MLThe Pediatric infectious disease journalRotavirus Serum IgA Immune Response in Children Receiving Rotarix Coadministered With bOPV or IPV. Pediatr Infect Dis J. 2016 10; 35(10):1137-9.Pediatr Infect Dis J2016-10-01T00:00:002016Rotavirus Serum IgA Immune Response in Children Receiving Rotarix Coadministered With bOPV or IPV.27466422Qu L, Murakami K, Broughman JR, Lay MK, Guix S, Tenge VR, Atmar RL, Estes MKJournal of virologyReplication of Human Norovirus RNA in Mammalian Cells Reveals Lack of Interferon Response. J Virol. 2016 10 01; 90(19):8906-23.J Virol2016-09-12T00:00:002016Replication of Human Norovirus RNA in Mammalian Cells Reveals Lack of Interferon Response.27619793Lloyd RE, Estes MKCurrent opinion in virologyEditorial overview: Viruses and cell metabolism. Curr Opin Virol. 2016 08; 19:vii-viii.Curr Opin Virol2016-08-01T00:00:002016Editorial overview: Viruses and cell metabolism.12610132Glass PJ, Zeng CQ, Estes MKJournal of virologyTwo nonoverlapping domains on the Norwalk virus open reading frame 3 (ORF3) protein are involved in the formation of the phosphorylated 35K protein and in ORF3-capsid protein interactions. J Virol. 2003 Mar; 77(6):3569-77.J Virol2003-03-01T00:00:002003Two nonoverlapping domains on the Norwalk virus open reading frame 3 (ORF3) protein are involved in the formation of the phosphorylated 35K protein and in ORF3-capsid protein interactions.17506819Beau I, Cotte-Laffitte J, G?niteau-Legendre M, Estes MK, Servin ALCellular microbiologyAn NSP4-dependant mechanism by which rotavirus impairs lactase enzymatic activity in brush border of human enterocyte-like Caco-2 cells. Cell Microbiol. 2007 Sep; 9(9):2254-66.Cell Microbiol2007-05-15T00:00:002007An NSP4-dependant mechanism by which rotavirus impairs lactase enzymatic activity in brush border of human enterocyte-like Caco-2 cells.Authorship 3275182Authorship 3275551427352632Mills M, Estes MKDrug discovery todayPhysiologically relevant human tissue models for infectious diseases. Drug Discov Today. 2016 09; 21(9):1540-1552.Drug Discov Today2016-06-25T00:00:002016Physiologically relevant human tissue models for infectious diseases.27412790Karandikar UC, Crawford SE, Ajami NJ, Murakami K, Kou B, Ettayebi K, Papanicolaou GA, Jongwutiwes U, Perales MA, Shia J, Mercer D, Finegold MJ, Vinj? J, Atmar RL, Estes MKThe Journal of general virologyDetection of human norovirus in intestinal biopsies from immunocompromised transplant patients. J Gen Virol. 2016 09; 97(9):2291-2300.J Gen Virol2016-07-12T00:00:002016Detection of human norovirus in intestinal biopsies from immunocompromised transplant patients.12922123Bertolotti-Ciarlet A, Ciarlet M, Crawford SE, Conner ME, Estes MKVaccineImmunogenicity and protective efficacy of rotavirus 2/6-virus-like particles produced by a dual baculovirus expression vector and administered intramuscularly, intranasally, or orally to mice. Vaccine. 2003 Sep 08; 21(25-26):3885-900.Vaccine2003-09-08T00:00:002003Immunogenicity and protective efficacy of rotavirus 2/6-virus-like particles produced by a dual baculovirus expression vector and administered intramuscularly, intranasally, or orally to mice.15539501Moe CL, Sair A, Lindesmith L, Estes MK, Jaykus LAClinical and diagnostic laboratory immunologyDiagnosis of norwalk virus infection by indirect enzyme immunoassay detection of salivary antibodies to recombinant norwalk virus antigen. Clin Diagn Lab Immunol. 2004 Nov; 11(6):1028-34.Clin Diagn Lab Immunol2004-11-01T00:00:002004Diagnosis of norwalk virus infection by indirect enzyme immunoassay detection of salivary antibodies to recombinant norwalk virus antigen.18826818Atmar RL, Opekun AR, Gilger MA, Estes MK, Crawford SE, Neill FH, Graham DYEmerging infectious diseasesNorwalk virus shedding after experimental human infection. Emerg Infect Dis. 2008 Oct; 14(10):1553-7.Emerg Infect Dis2008-10-01T00:00:002008Norwalk virus shedding after experimental human infection.19036817Li Z, Baker ML, Jiang W, Estes MK, Prasad BVJournal of virologyRotavirus architecture at subnanometer resolution. J Virol. 2009 Feb; 83(4):1754-66.J Virol2008-11-26T00:00:002008Rotavirus architecture at subnanometer resolution.15894109Scofield VL, Montufar-Solis D, Cheng E, Estes MK, Klein JRImmunology lettersIntestinal TSH production is localized in crypt enterocytes and in villus 'hotblocks' and is coupled to IL-7 production: evidence for involvement of TSH during acute enteric virus infection. Immunol Lett. 2005 Jun 15; 99(1):36-44.Immunol Lett2005-01-07T00:00:002005Intestinal TSH production is localized in crypt enterocytes and in villus 'hotblocks' and is coupled to IL-7 production: evidence for involvement of TSH during acute enteric virus infection.15012630Huang H, Schroeder F, Estes MK, McPherson T, Ball JMThe Biochemical journalInteraction(s) of rotavirus non-structural protein 4 (NSP4) C-terminal peptides with model membranes. Biochem J. 2004 Jun 15; 380(Pt 3):723-33.Biochem J2004-06-15T00:00:002004Interaction(s) of rotavirus non-structural protein 4 (NSP4) C-terminal peptides with model membranes.15919896Parker TD, Kitamoto N, Tanaka T, Hutson AM, Estes MKJournal of virologyIdentification of Genogroup I and Genogroup II broadly reactive epitopes on the norovirus capsid. 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J Virol. 2019 03 15; 93(6).J Virol2019-03-05T00:00:002019GII.4 Norovirus Protease Shows pH-Sensitive Proteolysis with a Unique Arg-His Pairing in the Catalytic Site.1992-11-30NIHESTES, MARY KOLB1984-09-30ANTIGENIC VARIATION OF HUMAN ROTAVIRUSESR01AI0206491991-11-30NIHESTES, MARY KOLB1990-12-01INTERNATIONAL SYMPOSIUM ON DOUBLE-STRANDED RNA VIRUSESR13AI0304882015-01-31NIHESTES, MARY KOLB2009-08-11Regulation of Rotavirus ReplicationR56AI0806562025-07-31NIHATMAR, ROBERT L.;ESTES, MARY KOLB ;PRASAD, BIDADI VENKATARAM2003-12-01Mechanisms of Norovirus Pathogenesis and Replication to Develop TherapeuticsP01AI0577882004-12-31NIHESTES, MARY KOLB2000-01-15MOLECULAR AND ANTIGENIC ANALYSIS OF HUMAN CALICIVIRUSR01AI0465812025-03-31NIHCRAWFORD, SUE ELLEN;ESTES, MARY KOLB2009-08-11Regulation of Rotavirus ReplicationR01AI0806562018-06-30NIHESTES, MARY KOLB2013-07-01Intestinal and Milk Glycan Expression in Restriction of Neonatal InfectionR01AI1051012000-09-29NIHESTES, MARY KOLB1997-09-30MUCOSAL VACCINE FOR HIVR21AI0426462024-08-31NIHESTES, MARY KOLB2014-09-05Intestinal Niche in Homeostasis and Epithelial RegenerationU01DK1031681995-06-30NIHESTES, MARY KOLB1990-07-01DEVELOPMENT OF DIAGNOSTIC TESTS FOR NORWALK VIRUSESU01AI0304482006-06-30NIHESTES, MARY KOLB1981-08-01MOLECULAR BIOLOGY OF THE ROTAVIRUSESR01DK0301442026-05-31NIHESTES, MARY KOLB ;MARESSO, ANTHONY W;PIEDRA, PEDRO A2015-03-15Human Biomimetics for Mucosal InfectionsU19AI1164971989-07-31NIHESTES, MARY KOLB1981-08-01MOLECULAR BIOLOGY OF THE ROTAVIRUSESR01AM0301441991-07-31NIHESTES, MARY KOLB1984-09-30ANTIGENIC VARIATION OF HUMAN ROTAVIRUSESR22AI0206492023-08-31NIHEL-SERAG, HASHEM B1999-12-01Texas Medical Center Digestive Diseases CenterP30DK0563382009-06-30NIHESTES, MARY KOLB1981-08-01Molecular Biology of the RotavirusesR56DK0301442014-11-30NIHCONNER, MARGARET E.1987-07-01Intestinal Mucosal ImmunityR01AI0249981999-06-30NIHESTES, MARY KOLB1995-07-01STRUCTURE DIRECTED ANTIVIRAL STRATEGIES FOR CALICIVIRUSEU01AI0380362025-06-30NIHESTES, MARY KOLB;GIORDANO, THOMAS P2003-08-01Research Training in Infection and ImmunityT32AI0554132011-04-30NIHESTES, MARY KOLB2007-07-01CALICIVIRAL INFECTIONS AND DISEASE IN SOUTHERN INDIAR03TW0077642020-06-30NIHVAN DEN VEYVER, IGNATIA B2010-07-01Training Program in Translational Biology and Molecular MedicineT32GM088129Principal InvestigatorPrincipal InvestigatorPrincipal InvestigatorPrincipal InvestigatorPrincipal InvestigatorPrincipal InvestigatorCo-Principal InvestigatorCo-Principal InvestigatorPrincipal InvestigatorPrincipal InvestigatorPrincipal InvestigatorPrincipal InvestigatorPrincipal InvestigatorPrincipal InvestigatorPrincipal InvestigatorCo-Principal InvestigatorPrincipal InvestigatorPrincipal InvestigatorPrincipal InvestigatorPrincipal InvestigatorDepartment of MedicineDepartment of Molecular Virology & MicrobiologyDepartment of RadiologyRadiologyMedicine-Gastroenterology & HepatolMedicine-Infectious DiseaseMolecular Virology & MicrobiologyBaylor College of MedicineJAMESCROWEJAMES CROWE0.000000000000000.000000000000001560CROWE, JAMESAssociate ProfessorSARAHBLUTTSARAH BLUTT0.000000000000000.000000000000002152BLUTT, SARAHAssociate Professor15.8060.00647667729research areas11.21910.015909289coauthor of623.63826.420960similar to11259selected publicationsF. BLAINEHOLLINGERF. BLAINE HOLLINGER0.000000000000000.000000000000002388HOLLINGER, F. BLAINEProfessor EmeritusROBERTATMARROBERT ATMAR0.000000000000000.000000000000003695ATMAR, ROBERTProfessorJASONKIMATAJASON KIMATA0.000000000000000.00000000000000630KIMATA, JASONAssociate ProfessorJOSEPHHYSERPKNhszORdNrVRIzgrn7GPw==JOSEPH HYSER0.000000000000000.0000000000000092HYSER, JOSEPHAssociate ProfessorERVINADAMERVIN ADAM0.000000000000000.000000000000002231ADAM, ERVINProfessor EmeritusAuthorship 944984830950121Uotani T, Murakami K, Uchida T, Tanaka S, Nagashima H, Zeng XL, Akada J, Estes MK, Graham DY, Yamaoka YHelicobacterChanges of tight junction and interleukin-8 expression using a human gastroid monolayer model of Helicobacter pylori infection. 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Viruses. 2019 07 11; 11(7).Viruses2019-07-11T00:00:002019Human Norovirus Cultivation in Nontransformed Stem Cell-Derived Human Intestinal Enteroid Cultures: Success and Challenges.31346185Chang-Graham AL, Perry JL, Strtak AC, Ramachandran NK, Criglar JM, Philip AA, Patton JT, Estes MK, Hyser JMScientific reportsRotavirus Calcium Dysregulation Manifests as Dynamic Calcium Signaling in the Cytoplasm and Endoplasmic Reticulum. Sci Rep. 2019 07 25; 9(1):10822.Sci Rep2019-07-25T00:00:002019Rotavirus Calcium Dysregulation Manifests as Dynamic Calcium Signaling in the Cytoplasm and Endoplasmic Reticulum.Authorship 11091510Authorship 953707331403623Fasciano AC, Blutt SE, Estes MK, Mecsas JJournal of visualized experiments : JoVEInduced Differentiation of M Cell-like Cells in Human Stem Cell-derived Ileal Enteroid Monolayers. J Vis Exp. 2019 07 26; (149).J Vis Exp2019-07-26T00:00:002019Induced Differentiation of M Cell-like Cells in Human Stem Cell-derived Ileal Enteroid Monolayers.Authorship 954321531441758Chan MC, Cheung SKC, Mohammad KN, Chan JCM, Estes MK, Chan PKSEmerging infectious diseasesUse of Human Intestinal Enteroids to Detect ?Human Norovirus Infectivity. Emerg Infect Dis. 2019 09; 25(9):1730-1735.Emerg Infect Dis2019-09-01T00:00:002019Use of Human Intestinal Enteroids to Detect ?Human Norovirus Infectivity.Authorship 954521931452173Cardenas D, Bhalchandra S, Lamisere H, Chen Y, Zeng XL, Ramani S, Karandikar UC, Kaplan DL, Estes MK, Ward HDMethods in molecular biology (Clifton, N.J.)Two- and Three-Dimensional Bioengineered Human Intestinal Tissue Models for Cryptosporidium. Methods Mol Biol. 2020; 2052:373-402.Methods Mol Biol2020-01-01T00:00:002020Two- and Three-Dimensional Bioengineered Human Intestinal Tissue Models for Cryptosporidium.Authorship 954781631473225Tapia R, Perez-Yepez EA, Carlino MJ, Karandikar UC, Kralicek SE, Estes MK, Hecht GAGastroenterologySperm Flagellar 1 Binds Actin in Intestinal Epithelial Cells and Contributes to Formation of Filopodia and Lamellipodia. Gastroenterology. 2019 12; 157(6):1544-1555.e3.Gastroenterology2019-08-29T00:00:002019Sperm Flagellar 1 Binds Actin in Intestinal Epithelial Cells and Contributes to Formation of Filopodia and Lamellipodia.Authorship 956279131573467Vinj? J, Estes MK, Esteves P, Green KY, Katayama K, Knowles NJ, L'Homme Y, Martella V, Vennema H, White PAThe Journal of general virologyICTV Virus Taxonomy Profile: Caliciviridae. J Gen Virol. 2019 11; 100(11):1469-1470.J Gen Virol2019-11-01T00:00:002019ICTV Virus Taxonomy Profile: Caliciviridae.Authorship 9568056Authorship 956955531597778Crawford SE, Criglar JM, Liu Z, Broughman JR, Estes MKJournal of virologyCOPII Vesicle Transport Is Required for Rotavirus NSP4 Interaction with the Autophagy Protein LC3 II and Trafficking to Viroplasms. J Virol. 2019 12 12; 94(1).J Virol2019-12-12T00:00:002019COPII Vesicle Transport Is Required for Rotavirus NSP4 Interaction with the Autophagy Protein LC3 II and Trafficking to Viroplasms.31589468Blutt SE, Klein OD, Donowitz M, Shroyer N, Guha C, Estes MKAmerican journal of physiology. Gastrointestinal and liver physiologyUse of organoids to study regenerative responses to intestinal damage. Am J Physiol Gastrointest Liver Physiol. 2019 12 01; 317(6):G845-G852.Am J Physiol Gastrointest Liver Physiol2019-10-07T00:00:002019Use of organoids to study regenerative responses to intestinal damage.Authorship 957246731613328Atmar RL, Ettayebi K, Ayyar BV, Neill FH, Braun RP, Ramani S, Estes MKThe Journal of infectious diseasesComparison of Microneutralization and Histo-Blood Group Antigen-Blocking Assays for Functional Norovirus Antibody Detection. J Infect Dis. 2020 02 18; 221(5):739-743.J Infect Dis2020-02-18T00:00:002020Comparison of Microneutralization and Histo-Blood Group Antigen-Blocking Assays for Functional Norovirus Antibody Detection.Authorship 957831731649646Engevik MA, Morra CN, R?th D, Engevik K, Spinler JK, Devaraj S, Crawford SE, Estes MK, Kalkum M, Versalovic JFrontiers in microbiologyMicrobial Metabolic Capacity for Intestinal Folate Production and Modulation of Host Folate Receptors. Front Microbiol. 2019; 10:2305.Front Microbiol2019-10-09T00:00:002019Microbial Metabolic Capacity for Intestinal Folate Production and Modulation of Host Folate Receptors.2Distinguished Service ProfessorDistinguished Service Professor3Distinguished Service ProfessorDistinguished Service Professortrue1Distinguished Service ProfessorDistinguished Service ProfessorAuthorship 961048231726023Blutt SE, Estes MKCell host & microbeGut Bacterial Bouncers: Keeping Viral Pathogens out of the Epithelium. Cell Host Microbe. 2019 11 13; 26(5):569-570.Cell Host Microbe2019-11-13T00:00:002019Gut Bacterial Bouncers: Keeping Viral Pathogens out of the Epithelium.Authorship 1121252Authorship 1090051Authorship 9751131531896578Murakami K, Tenge VR, Karandikar UC, Lin SC, Ramani S, Ettayebi K, Crawford SE, Zeng XL, Neill FH, Ayyar BV, Katayama K, Graham DY, Bieberich E, Atmar RL, Estes MKProceedings of the National Academy of Sciences of the United States of AmericaBile acids and ceramide overcome the entry restriction for GII.3 human norovirus replication in human intestinal enteroids. Proc Natl Acad Sci U S A. 2020 01 21; 117(3):1700-1710.Proc Natl Acad Sci U S A2020-01-02T00:00:002020Bile acids and ceramide overcome the entry restriction for GII.3 human norovirus replication in human intestinal enteroids.Authorship 1128924Authorship 977828332046599Hewes SA, Wilson RL, Estes MK, Shroyer NF, Blutt SE, Grande-Allen KJTissue engineering. Part B, ReviewsIn Vitro Models of the Small Intestine: Engineering Challenges and Engineering Solutions. Tissue Eng Part B Rev. 2020 08; 26(4):313-326.Tissue Eng Part B Rev2020-03-23T00:00:002020In Vitro Models of the Small Intestine: Engineering Challenges and Engineering Solutions.ADRIENNEMCNEESADRIENNE MCNEES0.000000000000000.000000000000005767MCNEES, ADRIENNEAdjunct InstructorSASIREKHARAMANISASIREKHA RAMANI0.000000000000000.000000000000005956RAMANI, SASIREKHAAssistant ProfessorSTEPHANIEFOWLERSTEPHANIE FOWLER0.000000000000000.000000000000006343FOWLER, STEPHANIEAssistant ProfessorAuthorship 9789102Authorship 1148864Authorship 9793301232147796Stewart CJ, Estes MK, Ramani SMethods in molecular biology (Clifton, N.J.)Establishing Human Intestinal Enteroid/Organoid Lines from Preterm Infant and Adult Tissue. Methods Mol Biol. 2020; 2121:185-198.Methods Mol Biol2020-01-01T00:00:002020Establishing Human Intestinal Enteroid/Organoid Lines from Preterm Infant and Adult Tissue.32184242Haga K, Ettayebi K, Tenge VR, Karandikar UC, Lewis MA, Lin SC, Neill FH, Ayyar BV, Zeng XL, Larson G, Ramani S, Atmar RL, Estes MKmBioGenetic Manipulation of Human Intestinal Enteroids Demonstrates the Necessity of a Functional Fucosyltransferase 2 Gene for Secretor-Dependent Human Norovirus Infection. mBio. 2020 03 17; 11(2).mBio2020-03-17T00:00:002020Genetic Manipulation of Human Intestinal Enteroids Demonstrates the Necessity of a Functional Fucosyltransferase 2 Gene for Secretor-Dependent Human Norovirus Infection.true1Associate ProfessorAssociate Professortrue1Professor EmeritusProfessor EmeritusAuthorship 9865531532251490Graziano VR, Walker FC, Kennedy EA, Wei J, Ettayebi K, Strine MS, Filler RB, Hassan E, Hsieh LL, Kim AS, Kolawole AO, Wobus CE, Lindesmith LC, Baric RS, Estes MK, Orchard RC, Baldridge MT, Wilen CBPLoS pathogensCD300lf is the primary physiologic receptor of murine norovirus but not human norovirus. PLoS Pathog. 2020 04; 16(4):e1008242.PLoS Pathog2020-04-06T00:00:002020CD300lf is the primary physiologic receptor of murine norovirus but not human norovirus.Authorship 1158075Authorship 988119232336850Atmar RL, Estes MKClinical microbiology newsletterNonculturable agents of viral gastroenteritis. Clin Microbiol Newsl. 1997 Dec 01; 19(23):177-182.Clin Microbiol Newsl1997-12-01T00:00:001997Nonculturable agents of viral gastroenteritis.Authorship 990334632461314Criglar JM, Crawford SE, Zhao B, Smith HG, Stossi F, Estes MKJournal of virologyA Genetically Engineered Rotavirus NSP2 Phosphorylation Mutant Impaired in Viroplasm Formation and Replication Shows an Early Interaction between vNSP2 and Cellular Lipid Droplets. J Virol. 2020 07 16; 94(15).J Virol2020-07-16T00:00:002020A Genetically Engineered Rotavirus NSP2 Phosphorylation Mutant Impaired in Viroplasm Formation and Replication Shows an Early Interaction between vNSP2 and Cellular Lipid Droplets.Authorship 9909621032494598Kumar D, Yu X, Crawford SE, Moreno R, Jakana J, Sankaran B, Anish R, Kaundal S, Hu L, Estes MK, Wang Z, Prasad BVVScience advances2.7 ? cryo-EM structure of rotavirus core protein VP3, a unique capping machine with a helicase activity. Sci Adv. 2020 04; 6(16):eaay6410.Sci Adv2020-04-15T00:00:0020202.7 ? cryo-EM structure of rotavirus core protein VP3, a unique capping machine with a helicase activity.Co-Principal Investigator2021-08-14NIHESTES, MARY KOLB2020-08-15Confocal Microscope (Zeiss LSM980 with Airyscan 2)S10OD028480Principal InvestigatorAuthorship 99924815Authorship 99930510Authorship 9996001232930708Olvera A, Carter H, Rajan A, Carlin LG, Yu X, Zeng XL, Shelburne S, Bhatti M, Blutt SE, Shroyer NF, Jenq R, Estes MK, Maresso A, Okhuysen PCClinical infectious diseases : an official publication of the Infectious Diseases Society of AmericaEnteropathogenic Escherichia coli Infection in Cancer and Immunosuppressed Patients. Clin Infect Dis. 2021 05 18; 72(10):e620-e629.Clin Infect Dis2021-05-18T00:00:002021Enteropathogenic Escherichia coli Infection in Cancer and Immunosuppressed Patients.32907944Lin SC, Qu L, Ettayebi K, Crawford SE, Blutt SE, Robertson MJ, Zeng XL, Tenge VR, Ayyar BV, Karandikar UC, Yu X, Coarfa C, Atmar RL, Ramani S, Estes MKProceedings of the National Academy of Sciences of the United States of AmericaHuman norovirus exhibits strain-specific sensitivity to host interferon pathways in human intestinal enteroids. Proc Natl Acad Sci U S A. 2020 09 22; 117(38):23782-23793.Proc Natl Acad Sci U S A2020-09-09T00:00:002020Human norovirus exhibits strain-specific sensitivity to host interferon pathways in human intestinal enteroids.32913124Rimkute I, Thorsteinsson K, Henricsson M, Tenge VR, Yu X, Lin SC, Haga K, Atmar RL, Lycke N, Nilsson J, Estes MK, Bally M, Larson GThe Journal of biological chemistryHisto-blood group antigens of glycosphingolipids predict susceptibility of human intestinal enteroids to norovirus infection. J Biol Chem. 2020 11 20; 295(47):15974-15987.J Biol Chem2020-09-10T00:00:002020Histo-blood group antigens of glycosphingolipids predict susceptibility of human intestinal enteroids to norovirus infection.Authorship 9998833332958778Chakravarti D, Hu B, Mao X, Rashid A, Li J, Li J, Liao WT, Whitley EM, Dey P, Hou P, LaBella KA, Chang A, Wang G, Spring DJ, Deng P, Zhao D, Liang X, Lan Z, Lin Y, Sarkar S, Terranova C, Deribe YL, Blutt SE, Okhuysen P, Zhang J, Vilar E, Nielsen OH, Dupont A, Younes M, Patel KR, Shroyer NF, Rai K, Estes MK, Wang YA, Bertuch AA, DePinho RANature communicationsTelomere dysfunction activates YAP1 to drive tissue inflammation. Nat Commun. 2020 09 21; 11(1):4766.Nat Commun2020-09-21T00:00:002020Telomere dysfunction activates YAP1 to drive tissue inflammation.Authorship 10010172332986782Rajan A, Robertson MJ, Carter HE, Poole NM, Clark JR, Green SI, Criss ZK, Zhao B, Karandikar U, Xing Y, Margalef-Catal? M, Jain N, Wilson RL, Bai F, Hyser JM, Petrosino J, Shroyer NF, Blutt SE, Coarfa C, Song X, Prasad BV, Amieva MR, Grande-Allen J, Estes MK, Okhuysen PC, Maresso AWPLoS pathogensEnteroaggregative E. coli Adherence to Human Heparan Sulfate Proteoglycans Drives Segment and Host Specific Responses to Infection. PLoS Pathog. 2020 09; 16(9):e1008851.PLoS Pathog2020-09-28T00:00:002020Enteroaggregative E. coli Adherence to Human Heparan Sulfate Proteoglycans Drives Segment and Host Specific Responses to Infection.Authorship 10028153Authorship 1002844633053412Criglar JM, Crawford SE, Estes MKVirus researchPlasmid-based reverse genetics for probing phosphorylation-dependent viroplasm formation in rotaviruses. Virus Res. 2021 01 02; 291:198193.Virus Res2020-10-11T00:00:002020Plasmid-based reverse genetics for probing phosphorylation-dependent viroplasm formation in rotaviruses.33055250Huang W, Soeung V, Boragine DM, Hu L, Prasad BVV, Estes MK, Atmar RL, Palzkill TJournal of virologyHigh-Resolution Mapping of Human Norovirus Antigens via Genomic Phage Display Library Selections and Deep Sequencing. J Virol. 2020 12 09; 95(1).J Virol2020-12-09T00:00:002020High-Resolution Mapping of Human Norovirus Antigens via Genomic Phage Display Library Selections and Deep Sequencing.Authorship 10033171033089106In JG, Yin J, Atanga R, Doucet M, Cole RN, DeVine L, Donowitz M, Zachos NC, Blutt SE, Estes MK, Kovbasnjuk OiScienceEpithelial WNT2B and Desert Hedgehog Are Necessary for Human Colonoid Regeneration after Bacterial Cytotoxin Injury. iScience. 2020 Oct 23; 23(10):101618.iScience2020-09-28T00:00:002020Epithelial WNT2B and Desert Hedgehog Are Necessary for Human Colonoid Regeneration after Bacterial Cytotoxin Injury.Authorship 100532612Authorship 100553712Authorship 1005752833246140Hasan NM, Johnson KF, Yin J, Baetz NW, Fayad L, Sherman V, Blutt SE, Estes MK, Kumbhari V, Zachos NC, Kovbasnjuk OMolecular metabolismIntestinal stem cell-derived enteroids from morbidly obese patients preserve obesity-related phenotypes: Elevated glucose absorption and gluconeogenesis. Mol Metab. 2021 02; 44:101129.Mol Metab2020-11-25T00:00:002020Intestinal stem cell-derived enteroids from morbidly obese patients preserve obesity-related phenotypes: Elevated glucose absorption and gluconeogenesis.33214249Chang-Graham AL, Perry JL, Engevik MA, Engevik KA, Scribano FJ, Gebert JT, Danhof HA, Nelson JC, Kellen JS, Strtak AC, Sastri NP, Estes MK, Britton RA, Versalovic J, Hyser JMScience (New York, N.Y.)Rotavirus induces intercellular calcium waves through ADP signaling. Science. 2020 11 20; 370(6519).Science2020-11-20T00:00:002020Rotavirus induces intercellular calcium waves through ADP signaling.33227279Engevik MA, Danhof HA, Auchtung J, Endres BT, Ruan W, Bass?res E, Engevik AC, Wu Q, Nicholson M, Luna RA, Garey KW, Crawford SE, Estes MK, Lux R, Yacyshyn MB, Yacyshyn B, Savidge T, Britton RA, Versalovic JGastroenterologyFusobacteriumnucleatum Adheres to Clostridioides difficile via the RadD Adhesin to Enhance Biofilm Formation in Intestinal Mucus. Gastroenterology. 2021 03; 160(4):1301-1314.e8.Gastroenterology2020-11-21T00:00:002020Fusobacteriumnucleatum Adheres to Clostridioides difficile via the RadD Adhesin to Enhance Biofilm Formation in Intestinal Mucus.Authorship 1007087733334213Wilson RL, Swaminathan G, Ettayebi K, Bomidi C, Zeng XL, Blutt SE, Estes MK, Grande-Allen KJTissue engineering. Part C, MethodsProtein-Functionalized Poly(ethylene glycol) Hydrogels as Scaffolds for Monolayer Organoid Culture. Tissue Eng Part C Methods. 2021 01; 27(1):12-23.Tissue Eng Part C Methods2021-01-01T00:00:002021Protein-Functionalized Poly(ethylene glycol) Hydrogels as Scaffolds for Monolayer Organoid Culture.Authorship 1008370733409849Wilson RL, Hewes SA, Rajan A, Lin SC, Bomidi C, Iida T, Estes MK, Maresso AW, Grande-Allen KJAnnals of biomedical engineeringA Millifluidic Perfusion Cassette for Studying the Pathogenesis of Enteric Infections Using Ex-Vivo Organoids. Ann Biomed Eng. 2021 Apr; 49(4):1233-1244.Ann Biomed Eng2021-01-06T00:00:002021A Millifluidic Perfusion Cassette for Studying the Pathogenesis of Enteric Infections Using Ex-Vivo Organoids.Authorship 10100121233504663Ettayebi K, Tenge VR, Cortes-Penfield NW, Crawford SE, Neill FH, Zeng XL, Yu X, Ayyar BV, Burrin D, Ramani S, Atmar RL, Estes MKmSphereNew Insights and Enhanced Human Norovirus Cultivation in Human Intestinal Enteroids. mSphere. 2021 01 27; 6(1).mSphere2021-01-27T00:00:002021New Insights and Enhanced Human Norovirus Cultivation in Human Intestinal Enteroids.Authorship 1160343Authorship 12099711Authorship 1216993Authorship 1019498434044593Nguyen NK, Burnham CD, Casadevall A, Estes MK, Ferrell RV, Fleiszig SMJ, speakers, moderators, and panelists of the ASM Virtual Symposium: Microbial Science Research in the mBioMicrobial Science Research in the Post-COVID Environment. mBio. 2021 06 29; 12(3):e0111621.mBio2021-05-28T00:00:002021Microbial Science Research in the Post-COVID Environment.Authorship 10201089Authorship 1020114434071855Tenge VR, Murakami K, Salmen W, Lin SC, Crawford SE, Neill FH, Prasad BVV, Atmar RL, Estes MKVirusesBile Goes Viral. Viruses. 2021 05 27; 13(6).Viruses2021-05-27T00:00:002021Bile Goes Viral.34071878Crawford SE, Ramani S, Blutt SE, Estes MKVirusesOrganoids to Dissect Gastrointestinal Virus-Host Interactions: What Have We Learned? Viruses. 2021 05 27; 13(6).Viruses2021-05-27T00:00:002021Organoids to Dissect Gastrointestinal Virus-Host Interactions: What Have We Learned?true1Assistant ProfessorAssistant ProfessorAuthorship 1024178334189156Kondapi DS, Ramani S, Estes MK, Atmar RL, Okhuysen PCOpen forum infectious diseasesNorovirus in Cancer Patients: A Review. Open Forum Infect Dis. 2021 Jun; 8(6):ofab126.Open Forum Infect Dis2021-03-14T00:00:002021Norovirus in Cancer Patients: A Review.Authorship 102495226Authorship 1025108634253611Chakravarti D, Lee R, Multani AS, Santoni A, Keith Z, Hsu WH, Chang K, Reyes L, Rashid A, Wu CJ, Li J, Zhang J, Shim HS, Chandra K, Deng P, Spring DJ, Nielsen OH, Riis LB, Mayigegowda KK, Blutt SE, Zhang J, Younes M, DuPont A, Thirumurthi S, Vilar E, Estes MK, Colla S, Shroyer NF, DePinho RAProceedings of the National Academy of Sciences of the United States of AmericaTelomere dysfunction instigates inflammation in inflammatory bowel disease. Proc Natl Acad Sci U S A. 2021 07 20; 118(29).Proc Natl Acad Sci U S A2021-07-20T00:00:002021Telomere dysfunction instigates inflammation in inflammatory bowel disease.34262046Alvarado G, Salmen W, Ettayebi K, Hu L, Sankaran B, Estes MK, Venkataram Prasad BV, Crowe JENature communicationsBroadly cross-reactive human antibodies that inhibit genogroup I and II noroviruses. Nat Commun. 2021 07 14; 12(1):4320.Nat Commun2021-07-14T00:00:002021Broadly cross-reactive human antibodies that inhibit genogroup I and II noroviruses.Authorship 102563213Authorship 10258001334280559Swaminathan G, Kamyabi N, Carter HE, Rajan A, Karandikar U, Criss ZK, Shroyer NF, Robertson MJ, Coarfa C, Huang C, Shannon TE, Tadros M, Estes MK, Maresso AW, Grande-Allen KJActa biomaterialiaEffect of substrate stiffness on human intestinal enteroids' infectivity by enteroaggregative Escherichia coli. Acta Biomater. 2021 09 15; 132:245-259.Acta Biomater2021-07-17T00:00:002021Effect of substrate stiffness on human intestinal enteroids' infectivity by enteroaggregative Escherichia coli.34288725Blutt SE, Crawford SE, Bomidi C, Zeng XL, Broughman JR, Robertson M, Coarfa C, Tessier MEM, Savidge T, Hollinger FB, Curley SA, Donowitz M, Estes MKAmerican journal of physiology. 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Am J Physiol Gastrointest Liver Physiol. 2021 09 01; 321(3):G270-G279.Am J Physiol Gastrointest Liver Physiol2021-07-21T00:00:002021Use of human tissue stem cell-derived organoid cultures to model enterohepatic circulation.Authorship 10271331734341793Rajan A, Weaver AM, Aloisio GM, Jelinski J, Johnson HL, Venable SF, McBride T, Aideyan L, Piedra FA, Ye X, Melicoff-Portillo E, Yerramilli MRK, Zeng XL, Mancini MA, Stossi F, Maresso AW, Kotkar SA, Estes MK, Blutt S, Avadhanula V, Piedra PAbioRxiv : the preprint server for biologyThe human nose organoid respiratory virus model: an ex-vivo human challenge model to study RSV and SARS-CoV-2 pathogenesis and evaluate therapeutics. bioRxiv. 2021 Jul 28.bioRxiv2021-07-28T00:00:002021The human nose organoid respiratory virus model: an ex-vivo human challenge model to study RSV and SARS-CoV-2 pathogenesis and evaluate therapeutics.2026-08-31NIHCRAWFORD, SUE ELLEN;ESTES, MARY KOLB;HYSER, JOSEPH M.2021-09-21Dissecting Rotavirus Viroporin and Enterotoxin Calcium Signaling PathwaysR01AI158683Co-Principal InvestigatorAuthorship 10310982734612061Criss ZK, Bhasin N, Di Rienzi SC, Rajan A, Deans-Fielder K, Swaminathan G, Kamyabi N, Zeng XL, Doddapaneni H, Menon VK, Chakravarti D, Estrella C, Yu X, Patil K, Petrosino JF, Fleet JC, Verzi MP, Christakos S, Helmrath MA, Arimura S, DePinho RA, Britton RA, Maresso AW, Grande-Allen KJ, Blutt SE, Crawford SE, Estes MK, Ramani S, Shroyer NFPhysiological genomicsDrivers of transcriptional variance in human intestinal epithelial organoids. Physiol Genomics. 2021 11 01; 53(11):486-508.Physiol Genomics2021-10-06T00:00:002021Drivers of transcriptional variance in human intestinal epithelial organoids.Authorship 10314832Authorship 1031530634650069Alvarado G, Salmen W, Ettayebi K, Hu L, Sankaran B, Estes MK, Venkataram Prasad BV, Crowe JENature communicationsAuthor Correction: Broadly cross-reactive human antibodies that inhibit genogroup I and II noroviruses. Nat Commun. 2021 Oct 14; 12(1):6090.Nat Commun2021-10-14T00:00:002021Author Correction: Broadly cross-reactive human antibodies that inhibit genogroup I and II noroviruses.34644153Blutt SE, Estes MKAnnual review of medicineOrganoid Models for Infectious Disease. Annu Rev Med. 2022 01 27; 73:167-182.Annu Rev Med2021-10-13T00:00:002021Organoid Models for Infectious Disease.Authorship 10323697Authorship 1032373534696498Zhao B, Hu L, Song Y, Patil K, Ramani S, Atmar RL, Estes MK, Prasad BVVVirusesNorovirus Protease Structure and Antivirals Development. 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Gut Microbes. 2021 Jan-Dec; 13(1):1988390.Gut Microbes2021-01-01T00:00:002021Yersinia pseudotuberculosis YopE prevents uptake by M cells and instigates M cell extrusion in human ileal enteroid-derived monolayers.34730374Hayashi T, Murakami K, Hirano J, Fujii Y, Yamaoka Y, Ohashi H, Watashi K, Estes MK, Muramatsu MmSphereDasabuvir Inhibits Human Norovirus Infection in Human Intestinal Enteroids. mSphere. 2021 12 22; 6(6):e0062321.mSphere2021-11-03T00:00:002021Dasabuvir Inhibits Human Norovirus Infection in Human Intestinal Enteroids.34732579Bomidi C, Robertson M, Coarfa C, Estes MK, Blutt SEProceedings of the National Academy of Sciences of the United States of AmericaSingle-cell sequencing of rotavirus-infected intestinal epithelium reveals cell-type specific epithelial repair and tuft cell infection. Proc Natl Acad Sci U S A. 2021 11 09; 118(45).Proc Natl Acad Sci U S A2021-11-09T00:00:002021Single-cell sequencing of rotavirus-infected intestinal epithelium reveals cell-type specific epithelial repair and tuft cell infection.Authorship 1035688634921063Masi AC, Fofanova TY, Lamb CA, Auchtung JM, Britton RA, Estes MK, Ramani S, Cockell SJ, Coxhead J, Embleton ND, Berrington JE, Petrosino JF, Stewart CJGutDistinct gene expression profiles between human preterm-derived and adult-derived intestinal organoids exposed to Enterococcus faecalis: a pilot study. Gut. 2021 Dec 17.Gut2021-12-17T00:00:002021Distinct gene expression profiles between human preterm-derived and adult-derived intestinal organoids exposed to Enterococcus faecalis: a pilot study.Authorship 10381548Authorship 10384638Authorship 103971211Authorship 10398498Authorship 103992017Authorship 10409834Authorship 1041556935143768Maeda K, Zachos NC, Orzalli MH, Schmieder SS, Chang D, Bugda Gwilt K, Doucet M, Baetz NW, Lee S, Crawford SE, Estes MK, Kagan JC, Turner JR, Lencer WICell host & microbeDepletion of the apical endosome in response to viruses and bacterial toxins provides cell-autonomous host defense at mucosal surfaces. Cell Host Microbe. 2022 02 09; 30(2):216-231.e5.Cell Host Microbe2022-02-09T00:00:002022Depletion of the apical endosome in response to viruses and bacterial toxins provides cell-autonomous host defense at mucosal surfaces.35297675Ettayebi K, Salmen W, Imai K, Hagi A, Neill FH, Atmar RL, Prasad BVV, Estes MKmBioAntiviral Activity of Olanexidine-Containing Hand Rub against Human Noroviruses. mBio. 2022 04 26; 13(2):e0284821.mBio2022-03-17T00:00:002022Antiviral Activity of Olanexidine-Containing Hand Rub against Human Noroviruses.35197604Lin SC, Haga K, Zeng XL, Estes MKNature protocolsGeneration of CRISPR-Cas9-mediated genetic knockout human intestinal tissue-derived enteroid lines by lentivirus transduction and single-cell cloning. Nat Protoc. 2022 Apr; 17(4):1004-1027.Nat Protoc2022-02-23T00:00:002022Generation of CRISPR-Cas9-mediated genetic knockout human intestinal tissue-derived enteroid lines by lentivirus transduction and single-cell cloning.35255136van Kampen JJA, Dalm VASH, Fraaij PLA, Oude Munnink BB, Schapendonk CME, Izquierdo-Lara RW, Villabruna N, Ettayebi K, Estes MK, Koopmans MPG, de Graaf MThe Journal of infectious diseasesClinical and In Vitro Evidence Favoring Immunoglobulin Treatment of a Chronic Norovirus Infection in a Patient With Common Variable Immunodeficiency. J Infect Dis. 2022 Nov 11; 226(10):1781-1789.J Infect Dis2022-11-11T00:00:002022Clinical and In Vitro Evidence Favoring Immunoglobulin Treatment of a Chronic Norovirus Infection in a Patient With Common Variable Immunodeficiency.35273142Hu L, Salmen W, Chen R, Zhou Y, Neill F, Crowe JE, Atmar RL, Estes MK, Prasad BVVNature communicationsAtomic structure of the predominant GII.4 human norovirus capsid reveals novel stability and plasticity. Nat Commun. 2022 03 10; 13(1):1241.Nat Commun2022-03-10T00:00:002022Atomic structure of the predominant GII.4 human norovirus capsid reveals novel stability and plasticity.35156656Gabriel V, Zdyrski C, Sahoo DK, Dao K, Bourgois-Mochel A, Kopper J, Zeng XL, Estes MK, Mochel JP, Allenspach KJournal of visualized experiments : JoVEStandardization and Maintenance of 3D Canine Hepatic and Intestinal Organoid Cultures for Use in Biomedical Research. J Vis Exp. 2022 01 31; (179).J Vis Exp2022-01-31T00:00:002022Standardization and Maintenance of 3D Canine Hepatic and Intestinal Organoid Cultures for Use in Biomedical Research.35164569Rajan A, Weaver AM, Aloisio GM, Jelinski J, Johnson HL, Venable SF, McBride T, Aideyan L, Piedra FA, Ye X, Melicoff-Portillo E, Yerramilli MRK, Zeng XL, Mancini MA, Stossi F, Maresso AW, Kotkar SA, Estes MK, Blutt S, Avadhanula V, Piedra PAmBioThe Human Nose Organoid Respiratory Virus Model: an Ex Vivo Human Challenge Model To Study Respiratory Syncytial Virus (RSV) and Severe Acute Respiratory Syndrome Coronavirus 2 (SARS-CoV-2) Pathogenesis and Evaluate Therapeutics. mBio. 2021 02 22; 13(1):e0351121.mBio2021-02-22T00:00:002021The Human Nose Organoid Respiratory Virus Model: an Ex Vivo Human Challenge Model To Study Respiratory Syncytial Virus (RSV) and Severe Acute Respiratory Syndrome Coronavirus 2 (SARS-CoV-2) Pathogenesis and Evaluate Therapeutics.Authorship 1373075Authorship 1374427Authorship 1374673Authorship 1376224Authorship 1378048Authorship 10448762Authorship 1045213735492603Criglar JM, Estes MK, Crawford SEFrontiers in physiologyRotavirus-Induced Lipid Droplet Biogenesis Is Critical for Virus Replication. Front Physiol. 2022; 13:836870.Front Physiol2022-03-23T00:00:002022Rotavirus-Induced Lipid Droplet Biogenesis Is Critical for Virus Replication.35513489Hu L, Salmen W, Sankaran B, Lasanajak Y, Smith DF, Crawford SE, Estes MK, Prasad BVVCommunications biologyNovel fold of rotavirus glycan-binding domain predicted by AlphaFold2 and determined by X-ray crystallography. Commun Biol. 2022 05 05; 5(1):419.Commun Biol2022-05-05T00:00:002022Novel fold of rotavirus glycan-binding domain predicted by AlphaFold2 and determined by X-ray crystallography.23887039Hertel PM, Crawford SE, Bessard BC, Estes MKVaccinePrevention of cholestasis in the murine rotavirus-induced biliary atresia model using passive immunization and nonreplicating virus-like particles. Vaccine. 2013 Nov 19; 31(48):5778-84.Vaccine2013-07-22T00:00:002013Prevention of cholestasis in the murine rotavirus-induced biliary atresia model using passive immunization and nonreplicating virus-like particles.24109210Hyser JM, Utama B, Crawford SE, Broughman JR, Estes MKJournal of virologyActivation of the endoplasmic reticulum calcium sensor STIM1 and store-operated calcium entry by rotavirus requires NSP4 viroporin activity. J Virol. 2013 Dec; 87(24):13579-88.J Virol2013-10-09T00:00:002013Activation of the endoplasmic reticulum calcium sensor STIM1 and store-operated calcium entry by rotavirus requires NSP4 viroporin activity.24198401Criglar JM, Hu L, Crawford SE, Hyser JM, Broughman JR, Prasad BV, Estes MKJournal of virologyA novel form of rotavirus NSP2 and phosphorylation-dependent NSP2-NSP5 interactions are associated with viroplasm assembly. J Virol. 2014 Jan; 88(2):786-98.J Virol2013-11-06T00:00:002013A novel form of rotavirus NSP2 and phosphorylation-dependent NSP2-NSP5 interactions are associated with viroplasm assembly.24232370Ramani S, Atmar RL, Estes MKCurrent opinion in gastroenterologyEpidemiology of human noroviruses and updates on vaccine development. Curr Opin Gastroenterol. 2014 Jan; 30(1):25-33.Curr Opin Gastroenterol2014-01-01T00:00:002014Epidemiology of human noroviruses and updates on vaccine development.24383649Ajami NJ, Kavanagh OV, Ramani S, Crawford SE, Atmar RL, Jiang ZD, Okhuysen PC, Estes MK, DuPont HLJournal of travel medicineSeroepidemiology of norovirus-associated travelers' diarrhea. J Travel Med. 2014 Jan-Feb; 21(1):6-11.J Travel Med2014-01-01T00:00:002014Seroepidemiology of norovirus-associated travelers' diarrhea.Authorship 1046762635632754Hayashi T, Yamaoka Y, Ito A, Kamaishi T, Sugiyama R, Estes MK, Muramatsu M, Murakami KVirusesEvaluation of Heat Inactivation of Human Norovirus in Freshwater Clams Using Human Intestinal Enteroids. Viruses. 2022 05 10; 14(5).Viruses2022-05-10T00:00:002022Evaluation of Heat Inactivation of Human Norovirus in Freshwater Clams Using Human Intestinal Enteroids.Authorship 1048913835731177Desdouits M, Polo D, Le Mennec C, Strubbia S, Zeng XL, Ettayebi K, Atmar RL, Estes MK, Le Guyader FSEmerging infectious diseasesUse of Human Intestinal Enteroids to Evaluate Persistence of Infectious Human Norovirus in Seawater. Emerg Infect Dis. 2022 07; 28(7):1475-1479.Emerg Infect Dis2022-07-01T00:00:002022Use of Human Intestinal Enteroids to Evaluate Persistence of Infectious Human Norovirus in Seawater.KHALILETTAYEBIKHALIL ETTAYEBI17787ETTAYEBI, KHALILInstructortrue1InstructorInstructortrue1Associate ProfessorAssociate ProfessorAuthorship 10555317Authorship 10558111036286526Lamisere H, Bhalchandra S, Kane AV, Zeng XL, Mo D, Adams W, Estes MK, Ward HDInfection and immunityDifferential Response to the Course of Cryptosporidium parvum Infection and Its Impact on Epithelial Integrity in Differentiated versus Undifferentiated Human Intestinal Enteroids. Infect Immun. 2022 11 17; 90(11):e0039722.Infect Immun2022-10-26T00:00:002022Differential Response to the Course of Cryptosporidium parvum Infection and Its Impact on Epithelial Integrity in Differentiated versus Undifferentiated Human Intestinal Enteroids.36640764Castillo-Azofeifa D, Wald T, Reyes EA, Gallagher A, Schanin J, Vlachos S, Lamarche-Vane N, Bomidi C, Blutt S, Estes MK, Nystul T, Klein ODCell stem cellA DLG1-ARHGAP31-CDC42 axis is essential for the intestinal stem cell response to fluctuating niche Wnt signaling. Cell Stem Cell. 2023 02 02; 30(2):188-206.e6.Cell Stem Cell2023-01-13T00:00:002023A DLG1-ARHGAP31-CDC42 axis is essential for the intestinal stem cell response to fluctuating niche Wnt signaling.Authorship 10647321136854760Ayyar BV, Ettayebi K, Salmen W, Karandikar UC, Neill FH, Tenge VR, Crawford SE, Bieberich E, Prasad BVV, Atmar RL, Estes MKNature communicationsCLIC and membrane wound repair pathways enable pandemic norovirus entry and infection. Nat Commun. 2023 02 28; 14(1):1148.Nat Commun2023-02-28T00:00:002023CLIC and membrane wound repair pathways enable pandemic norovirus entry and infection.Authorship 1067754837039654Euller-Nicolas G, Le Mennec C, Schaeffer J, Zeng XL, Ettayebi K, Atmar RL, Le Guyader FS, Estes MK, Desdouits MJournal of virologyHuman Sapovirus Replication in Human Intestinal Enteroids. J Virol. 2023 04 27; 97(4):e0038323.J Virol2023-04-11T00:00:002023Human Sapovirus Replication in Human Intestinal Enteroids.Authorship 187903Authorship 107349614Authorship 10740679Authorship 10729704Authorship 10733572437292968Adeniyi-Ipadeola GO, Hankins JD, Kambal A, Zeng XL, Patil K, Poplaski V, Bomidi C, Nguyen-Phuc H, Grimm SL, Coarfa C, Stossi F, Crawford SE, Blutt SE, Speer AL, Estes MK, Ramani SbioRxiv : the preprint server for biologyInfant and Adult Human Intestinal Enteroids are Morphologically and Functionally Distinct. bioRxiv. 2024 Feb 17.bioRxiv2024-02-17T00:00:002024Infant and Adult Human Intestinal Enteroids are Morphologically and Functionally Distinct.37398483Carter H, Clark J, Carlin LG, Vaughan E, Rajan A, Olvera A, Yu X, Zeng XL, Kambal A, Holder M, Qin X, Gibbs RA, Petrosino JF, Muzny DM, Doddapaneni H, Menon VK, Hoffman KL, Meng Q, Ross MC, Javornik Cregeen SJ, Metcalf G, Jenq R, Blutt S, Estes MK, TMC-GCID team, Maresso A, Okhuysen PCbioRxiv : the preprint server for biologyFunctional Genomics of Gastrointestinal Escherichia coli Isolated from Patients with Cancer and Diarrhea. bioRxiv. 2023 Jun 01.bioRxiv2023-06-01T00:00:002023Functional Genomics of Gastrointestinal Escherichia coli Isolated from Patients with Cancer and Diarrhea.37280322Su L, Huang W, Neill FH, Estes MK, Atmar RL, Palzkill TNPJ vaccinesMapping human norovirus antigens during infection reveals the breadth of the humoral immune response. NPJ Vaccines. 2023 Jun 06; 8(1):87.NPJ Vaccines2023-06-06T00:00:002023Mapping human norovirus antigens during infection reveals the breadth of the humoral immune response.37293103Lewis MA, Cort?s-Penfield NW, Ettayebi K, Patil K, Kaur G, Neill FH, Atmar RL, Ramani S, Estes MKbioRxiv : the preprint server for biologyA Standardized Antiviral Pipeline for Human Norovirus in Human Intestinal Enteroids Demonstrates No Antiviral Activity of Nitazoxanide. bioRxiv. 2023 May 23.bioRxiv2023-05-23T00:00:002023A Standardized Antiviral Pipeline for Human Norovirus in Human Intestinal Enteroids Demonstrates No Antiviral Activity of Nitazoxanide.Authorship 10795359Authorship 1078913737631252Marin-Muller C, Li D, L? JM, Liang Z, Vega-Mart?nez O, Crawford SE, Estes MK, Fisher WE, Chen C, Yao QPharmaceuticsNanoparticle-Mediated Therapy with miR-198 Sensitizes Pancreatic Cancer to Gemcitabine Treatment through Downregulation of VCP-Mediated Autophagy. Pharmaceutics. 2023 Jul 28; 15(8).Pharmaceutics2023-07-28T00:00:002023Nanoparticle-Mediated Therapy with miR-198 Sensitizes Pancreatic Cancer to Gemcitabine Treatment through Downregulation of VCP-Mediated Autophagy.37584657Kardia E, Fakhri O, Pavy M, Mason H, Huang N, Smertina E, Jenckel M, Peng NYG, Estes MK, Strive T, Frese M, Smith I, Hall RNThe Journal of general virologyHepatobiliary organoids derived from leporids support the replication of hepatotropic lagoviruses. J Gen Virol. 2023 08; 104(8).J Gen Virol2023-08-01T00:00:002023Hepatobiliary organoids derived from leporids support the replication of hepatotropic lagoviruses.Authorship 108023910Authorship 1080514937781879Atmar RL, Ettayebi K, Ramani S, Neill FH, Lindesmith L, Baric RS, Brinkman A, Braun R, Sherwood J, Estes MKThe Journal of infectious diseasesA Bivalent Human Norovirus Vaccine Induces Homotypic and Heterotypic Neutralizing Antibodies. J Infect Dis. 2023 Oct 02.J Infect Dis2023-10-02T00:00:002023A Bivalent Human Norovirus Vaccine Induces Homotypic and Heterotypic Neutralizing Antibodies.37787556Lewis MA, Cort?s-Penfield NW, Ettayebi K, Patil K, Kaur G, Neill FH, Atmar RL, Ramani S, Estes MKAntimicrobial agents and chemotherapyStandardization of an antiviral pipeline for human norovirus in human intestinal enteroids demonstrates nitazoxanide has no to weak antiviral activity. Antimicrob Agents Chemother. 2023 10 18; 67(10):e0063623.Antimicrob Agents Chemother2023-10-03T00:00:002023Standardization of an antiviral pipeline for human norovirus in human intestinal enteroids demonstrates nitazoxanide has no to weak antiviral activity.true1Adjunct InstructorAdjunct InstructorAuthorship 10815901337845211Salmen W, Hu L, Bok M, Chaimongkol N, Ettayebi K, Sosnovtsev SV, Soni K, Ayyar BV, Shanker S, Neill FH, Sankaran B, Atmar RL, Estes MK, Green KY, Parre?o V, Prasad BVVNature communicationsA single nanobody neutralizes multiple epochally evolving human noroviruses by modulating capsid plasticity. Nat Commun. 2023 10 16; 14(1):6516.Nat Commun2023-10-16T00:00:002023A single nanobody neutralizes multiple epochally evolving human noroviruses by modulating capsid plasticity.Authorship 10826291737909332Poplaski V, Bomidi C, Kambal A, Nguyen-Phuc H, Di Rienzi SC, Danhof HA, Zeng XL, Feagins LA, Deng N, Vilar E, McAllister F, Coarfa C, Min S, Kim HJ, Shukla R, Britton R, Estes MK, Blutt SEThe Journal of clinical investigationHuman intestinal organoids from Cronkhite-Canada syndrome patients reveal link between serotonin and proliferation. J Clin Invest. 2023 11 01; 133(21).J Clin Invest2023-11-01T00:00:002023Human intestinal organoids from Cronkhite-Canada syndrome patients reveal link between serotonin and proliferation.Authorship 205745Authorship 165023Authorship 1085575738079544Liu Z, Smith H, Criglar JM, Valentin AJ, Karandikar U, Zeng XL, Estes MK, Crawford SEProceedings of the National Academy of Sciences of the United States of AmericaRotavirus-mediated DGAT1 degradation: A pathophysiological mechanism of viral-induced malabsorptive diarrhea. Proc Natl Acad Sci U S A. 2023 Dec 19; 120(51):e2302161120.Proc Natl Acad Sci U S A2023-12-11T00:00:002023Rotavirus-mediated DGAT1 degradation: A pathophysiological mechanism of viral-induced malabsorptive diarrhea.Authorship 1087814838260626Tenge V, Vijayalakshmi Ayyar B, Ettayebi K, Crawford SE, Shen YT, Neill FH, Atmar RL, Estes MKbioRxiv : the preprint server for biologyBile acid-sensitive human norovirus strains are susceptible to sphingosine-1-phosphate receptor 2 inhibition. bioRxiv. 2024 Jan 03.bioRxiv2024-01-03T00:00:002024Bile acid-sensitive human norovirus strains are susceptible to sphingosine-1-phosphate receptor 2 inhibition.true1Professor EmeritusProfessor EmeritusAuthorship 197135Authorship 288858Authorship 246406Authorship 308292Authorship 32272Authorship 232602Authorship 347884Authorship 35114724648450Shanker S, Czako R, Sankaran B, Atmar RL, Estes MK, Prasad BVJournal of virologyStructural analysis of determinants of histo-blood group antigen binding specificity in genogroup I noroviruses. J Virol. 2014 Jun; 88(11):6168-80.J Virol2014-03-19T00:00:002014Structural analysis of determinants of histo-blood group antigen binding specificity in genogroup I noroviruses.24244836Deng L, Muhaxhiri Z, Estes MK, Palzkill T, Prasad BV, Song YMedChemCommSynthesis, Activity and Structure-Activity Relationship of Noroviral Protease Inhibitors. Medchemcomm. 2013 Oct; 4(10).Medchemcomm2013-10-01T00:00:002013Synthesis, Activity and Structure-Activity Relationship of Noroviral Protease Inhibitors.Authorship 372972Authorship 268287Authorship 379265Authorship 407614Authorship 412103Authorship 29782Authorship 3132910Authorship 455995Authorship 1411364Authorship 1425411124253285Atmar RL, Opekun AR, Gilger MA, Estes MK, Crawford SE, Neill FH, Ramani S, Hill H, Ferreira J, Graham DYThe Journal of infectious diseasesDetermination of the 50% human infectious dose for Norwalk virus. J Infect Dis. 2014 Apr 01; 209(7):1016-22.J Infect Dis2013-11-18T00:00:002013Determination of the 50% human infectious dose for Norwalk virus.24564938Kovbasnjuk O, Zachos NC, In J, Foulke-Abel J, Ettayebi K, Hyser JM, Broughman JR, Zeng XL, Middendorp S, de Jonge HR, Estes MK, Donowitz MStem cell research & therapyHuman enteroids: preclinical models of non-inflammatory diarrhea. Stem Cell Res Ther. 2013; 4 Suppl 1:S3.Stem Cell Res Ther2013-12-20T00:00:002013Human enteroids: preclinical models of non-inflammatory diarrhea.Authorship 345364Authorship 1436055Authorship 346113Authorship 507704Authorship 365944Authorship 529324Authorship 536927Authorship 551525Authorship 397278Authorship 420702Authorship 611178Authorship 459399Authorship 467495Authorship 67802Authorship 52282Authorship 735063Authorship 735404Authorship 737945Authorship 744922Authorship 793424Authorship 583452Authorship 583697Authorship 149496525231315Sastri NP, Viskovska M, Hyser JM, Tanner MR, Horton LB, Sankaran B, Prasad BV, Estes MKJournal of virologyStructural plasticity of the coiled-coil domain of rotavirus NSP4. J Virol. 2014 Dec; 88(23):13602-12.J Virol2014-09-17T00:00:002014Structural plasticity of the coiled-coil domain of rotavirus NSP4.25165107Viskovska M, Anish R, Hu L, Chow DC, Hurwitz AM, Brown NG, Palzkill T, Estes MK, Prasad BVJournal of virologyProbing the sites of interactions of rotaviral proteins involved in replication. J Virol. 2014 Nov; 88(21):12866-81.J Virol2014-08-27T00:00:002014Probing the sites of interactions of rotaviral proteins involved in replication.25048706Ashline DJ, Yu Y, Lasanajak Y, Song X, Hu L, Ramani S, Prasad V, Estes MK, Cummings RD, Smith DF, Reinhold VNMolecular & cellular proteomics : MCPStructural characterization by multistage mass spectrometry (MSn) of human milk glycans recognized by human rotaviruses. Mol Cell Proteomics. 2014 Nov; 13(11):2961-74.Mol Cell Proteomics2014-07-21T00:00:002014Structural characterization by multistage mass spectrometry (MSn) of human milk glycans recognized by human rotaviruses.25048705Yu Y, Lasanajak Y, Song X, Hu L, Ramani S, Mickum ML, Ashline DJ, Prasad BV, Estes MK, Reinhold VN, Cummings RD, Smith DFMolecular & cellular proteomics : MCPHuman milk contains novel glycans that are potential decoy receptors for neonatal rotaviruses. Mol Cell Proteomics. 2014 Nov; 13(11):2944-60.Mol Cell Proteomics2014-07-21T00:00:002014Human milk contains novel glycans that are potential decoy receptors for neonatal rotaviruses.25073118Venkataram Prasad BV, Shanker S, Hu L, Choi JM, Crawford SE, Ramani S, Czako R, Atmar RL, Estes MKCurrent opinion in virologyStructural basis of glycan interaction in gastroenteric viral pathogens. Curr Opin Virol. 2014 Aug; 7:119-27.Curr Opin Virol2014-07-27T00:00:002014Structural basis of glycan interaction in gastroenteric viral pathogens.25008934Qu L, Vongpunsawad S, Atmar RL, Prasad BV, Estes MKJournal of virologyDevelopment of a Gaussia luciferase-based human norovirus protease reporter system: cell type-specific profile of Norwalk virus protease precursors and evaluation of inhibitors. J Virol. 2014 Sep; 88(18):10312-26.J Virol2014-07-09T00:00:002014Development of a Gaussia luciferase-based human norovirus protease reporter system: cell type-specific profile of Norwalk virus protease precursors and evaluation of inhibitors.Authorship 5919615Authorship 603165Authorship 15089011Authorship 1512171024719375Foulke-Abel J, In J, Kovbasnjuk O, Zachos NC, Ettayebi K, Blutt SE, Hyser JM, Zeng XL, Crawford SE, Broughman JR, Estes MK, Donowitz MExperimental biology and medicine (Maywood, N.J.)Human enteroids as an ex-vivo model of host-pathogen interactions in the gastrointestinal tract. Exp Biol Med (Maywood). 2014 Sep; 239(9):1124-34.Exp Biol Med (Maywood)2014-04-09T00:00:002014Human enteroids as an ex-vivo model of host-pathogen interactions in the gastrointestinal tract.25192933Katayama K, Murakami K, Sharp TM, Guix S, Oka T, Takai-Todaka R, Nakanishi A, Crawford SE, Atmar RL, Estes MKProceedings of the National Academy of Sciences of the United States of AmericaPlasmid-based human norovirus reverse genetics system produces reporter-tagged progeny virus containing infectious genomic RNA. Proc Natl Acad Sci U S A. 2014 Sep 23; 111(38):E4043-52.Proc Natl Acad Sci U S A2014-09-05T00:00:002014Plasmid-based human norovirus reverse genetics system produces reporter-tagged progeny virus containing infectious genomic RNA.Authorship 1521038Authorship 866333Authorship 875497Authorship 1521389Authorship 152786424946948Huang W, Samanta M, Crawford SE, Estes MK, Neill FH, Atmar RL, Palzkill TProtein engineering, design & selection : PEDSIdentification of human single-chain antibodies with broad reactivity for noroviruses. Protein Eng Des Sel. 2014 Oct; 27(10):339-49.Protein Eng Des Sel2014-06-19T00:00:002014Identification of human single-chain antibodies with broad reactivity for noroviruses.SUECRAWFORDSUE CRAWFORD8067CRAWFORD, SUEAssistant ProfessorAuthorship 1533228Authorship 15334410Authorship 1534382Authorship 667722Authorship 932633Authorship 687526Authorship 713097Authorship 752994Authorship 777449Authorship 762382Authorship 1558533