JAMESCROWEJAMES CROWE0.000000000000000.000000000000001560CROWE, JAMESAssociate Professorprns:coAuthorOfcoauthor ofprns:endDateend dateFaculty Rankprns:fullNamefull nameprns:grantAwardedBygrant awarded byprns:hasAuthorListauthor listprns:hasFacultyRankhas faculty rankprns:hasNetworkhas networkprns:hasPublicationVenuepublished inprns:informationResourceReferenceinformation resource referenceprns:isPrimaryPositionis primary positionprns:latitudelatitudeprns:longitudelongitudeprns:mainImagephotoprns:maxWeightmaximum weightprns:medlineTAjournal title abbreviationprns:meshDescriptorUIMeSH DescriptorUIprns:meshSemanticGroupNameMeSH semantic group nameprns:minWeightminimum weightprns:numberOfAuthorsnumber of authorsprns:numberOfConnectionsnumber of connectionsprns:numberOfPublicationsnumber of publicationsprns:personIdPerson IDprns:personInPrimaryPositionperson in primary positionprns:physicalNeighborOfphysical neighborprns:positionInDepartmentposition in departmentprns:positionInDivisionposition in divisionprns:predicateNodepredicate nodeprns:principalInvestigatorNameprincipal investigator nameprns:publicationDatepublication dateprns:similarTosimilar toprns:sortOrdersort orderprns:startDatestart dateprns:uniquenessWeightuniqueness weightprns:yearyearAcademic ArticleArticleDocumentbibo:pmidPubMed IdentifierAddressvivo:address1address line 1vivo:addressCitycityvivo:addressPostalCodepostal codevivo:addressStatestate or provinceAgreementvivo:authorInAuthorshipselected publicationsvivo:authorRankauthor rank in publicationAuthorshipDepartmentDivisionGrantvivo:hasResearchArearesearch areasvivo:hasResearcherRoleresearch activitiesvivo:hrJobTitleHR job titleInformation Resourcevivo:linkedAuthorlinked authorvivo:linkedInformationResourcelinked information resourcevivo:mailingAddressmailing addressvivo:personInPositionpositionsPositionvivo:positionInOrganizationposition in organizationvivo:preferredTitlepreferred titleResearcher Rolevivo:researcherRoleOfresearcher role ofRolevivo:roleContributesTocontributes tovivo:sponsorAwardIdsponsor award idrdf:predicatepredicaterdf:typetyperdfs:labellabelConceptAgentfoaf:firstNamefirst namefoaf:lastNamelast nameOrganizationPersonAuthorship 156295425339762Hotard AL, Lee S, Currier MG, Crowe JE, Sakamoto K, Newcomb DC, Peebles RS, Plemper RK, Moore MLJournal of virologyIdentification of residues in the human respiratory syncytial virus fusion protein that modulate fusion activity and pathogenesis. J Virol. 2015 Jan; 89(1):512-22.J Virol2014-10-22T00:00:002014Identification of residues in the human respiratory syncytial virus fusion protein that modulate fusion activity and pathogenesis.Authorship 784285Authorship 804972Authorship 807722Authorship 809831Authorship 824925Authorship 839675Authorship 895328Authorship 887643Authorship 992116Authorship 10150411Authorship 1036626Authorship 1053139Authorship 1136665Authorship 1170605Authorship 11746916Authorship 133605Authorship 226035Authorship 2276711Authorship 236094Authorship 253167Authorship 1606442Authorship 1614219Authorship 16177810Authorship 1618064Authorship 1626761625609803Hooper KA, Crowe JE, Bloom JDJournal of virologyInfluenza viruses with receptor-binding N1 neuraminidases occur sporadically in several lineages and show no attenuation in cell culture or mice. J Virol. 2015 Apr; 89(7):3737-45.J Virol2015-01-21T00:00:002015Influenza viruses with receptor-binding N1 neuraminidases occur sporadically in several lineages and show no attenuation in cell culture or mice.25698059Fibriansah G, Tan JL, Smith SA, de Alwis R, Ng TS, Kostyuchenko VA, Jadi RS, Kukkaro P, de Silva AM, Crowe JE, Lok SMNature communicationsA highly potent human antibody neutralizes dengue virus serotype 3 by binding across three surface proteins. Nat Commun. 2015 Feb 20; 6:6341.Nat Commun2015-02-20T00:00:002015A highly potent human antibody neutralizes dengue virus serotype 3 by binding across three surface proteins.25713060Sim?es EA, DeVincenzo JP, Boeckh M, Bont L, Crowe JE, Griffiths P, Hayden FG, Hodinka RL, Smyth RL, Spencer K, Thirstrup S, Walsh EE, Whitley RJThe Journal of infectious diseasesChallenges and opportunities in developing respiratory syncytial virus therapeutics. J Infect Dis. 2015 Mar 15; 211 Suppl 1:S1-S20.J Infect Dis2015-03-15T00:00:002015Challenges and opportunities in developing respiratory syncytial virus therapeutics.25723164Flyak AI, Ilinykh PA, Murin CD, Garron T, Shen X, Fusco ML, Hashiguchi T, Bornholdt ZA, Slaughter JC, Sapparapu G, Klages C, Ksiazek TG, Ward AB, Saphire EO, Bukreyev A, Crowe JECellMechanism of human antibody-mediated neutralization of Marburg virus. Cell. 2015 Feb 26; 160(5):893-903.Cell2015-02-26T00:00:002015Mechanism of human antibody-mediated neutralization of Marburg virus.25723165Hashiguchi T, Fusco ML, Bornholdt ZA, Lee JE, Flyak AI, Matsuoka R, Kohda D, Yanagi Y, Hammel M, Crowe JE, Saphire EOCellStructural basis for Marburg virus neutralization by a cross-reactive human antibody. Cell. 2015 Feb 26; 160(5):904-912.Cell2015-02-26T00:00:002015Structural basis for Marburg virus neutralization by a cross-reactive human antibody.Authorship 267715Authorship 295634Authorship 32876Authorship 416622Authorship 445733Authorship 612814Authorship 736803Authorship 743611Authorship 90088Authorship 917923Authorship 959977Authorship 973145Authorship 99601126621 FANNINHouston, 77030TXAuthorship 2969135Authorship 29843010Authorship 2995758Authorship 30031212Authorship 30036012Authorship 30055812Authorship 3010891Authorship 3043942Authorship 30473416Authorship 30485614Authorship 3051755Authorship 3056382Authorship 30584812Authorship 305878325985274Willis JR, Sapparapu G, Murrell S, Julien JP, Singh V, King HG, Xia Y, Pickens JA, LaBranche CC, Slaughter JC, Montefiori DC, Wilson IA, Meiler J, Crowe JEThe Journal of clinical investigationRedesigned HIV antibodies exhibit enhanced neutralizing potency and breadth. J Clin Invest. 2015 Jun; 125(6):2523-31.J Clin Invest2015-05-18T00:00:002015Redesigned HIV antibodies exhibit enhanced neutralizing potency and breadth.26032420Callaway JB, Smith SA, McKinnon KP, de Silva AM, Crowe JE, Ting JPThe Journal of biological chemistrySpleen Tyrosine Kinase (Syk) Mediates IL-1? Induction by Primary Human Monocytes during Antibody-enhanced Dengue Virus Infection. J Biol Chem. 2015 Jul 10; 290(28):17306-20.J Biol Chem2015-06-01T00:00:002015Spleen Tyrosine Kinase (Syk) Mediates IL-1? Induction by Primary Human Monocytes during Antibody-enhanced Dengue Virus Infection.26104373Krause JC, Crowe JEMicrobiology spectrumCommitting the Oldest Sins in the Newest Kind of Ways-Antibodies Targeting the Influenza Virus Type A Hemagglutinin Globular Head. Microbiol Spectr. 2014 Oct; 2(5).Microbiol Spectr2014-10-01T00:00:002014Committing the Oldest Sins in the Newest Kind of Ways-Antibodies Targeting the Influenza Virus Type A Hemagglutinin Globular Head.26104564Smith SA, Crowe JEMicrobiology spectrumUse of Human Hybridoma Technology To Isolate Human Monoclonal Antibodies. Microbiol Spectr. 2015 Feb; 3(1):AID-0027-2014.Microbiol Spectr2015-02-01T00:00:002015Use of Human Hybridoma Technology To Isolate Human Monoclonal Antibodies.26138979Fibriansah G, Ibarra KD, Ng TS, Smith SA, Tan JL, Lim XN, Ooi JS, Kostyuchenko VA, Wang J, de Silva AM, Harris E, Crowe JE, Lok SMScience (New York, N.Y.)DENGUE VIRUS. Cryo-EM structure of an antibody that neutralizes dengue virus type 2 by locking E protein dimers. Science. 2015 Jul 03; 349(6243):88-91.Science2015-07-03T00:00:002015DENGUE VIRUS. Cryo-EM structure of an antibody that neutralizes dengue virus type 2 by locking E protein dimers.26147100Sevy AM, Jacobs TM, Crowe JE, Meiler JPLoS computational biologyDesign of Protein Multi-specificity Using an Independent Sequence Search Reduces the Barrier to Low Energy Sequences. PLoS Comput Biol. 2015 Jul; 11(7):e1004300.PLoS Comput Biol2015-07-06T00:00:002015Design of Protein Multi-specificity Using an Independent Sequence Search Reduces the Barrier to Low Energy Sequences.26159721Smith SA, Silva LA, Fox JM, Flyak AI, Kose N, Sapparapu G, Khomandiak S, Khomadiak S, Ashbrook AW, Kahle KM, Fong RH, Swayne S, Doranz BJ, McGee CE, Heise MT, Pal P, Brien JD, Austin SK, Diamond MS, Dermody TS, Crowe JECell host & microbeIsolation and Characterization of Broad and Ultrapotent Human Monoclonal Antibodies with Therapeutic Activity against Chikungunya Virus. Cell Host Microbe. 2015 Jul 08; 18(1):86-95.Cell Host Microbe2015-07-08T00:00:002015Isolation and Characterization of Broad and Ultrapotent Human Monoclonal Antibodies with Therapeutic Activity against Chikungunya Virus.26170302Winarski KL, Thornburg NJ, Yu Y, Sapparapu G, Crowe JE, Spiller BWProceedings of the National Academy of Sciences of the United States of AmericaVaccine-elicited antibody that neutralizes H5N1 influenza and variants binds the receptor site and polymorphic sites. Proc Natl Acad Sci U S A. 2015 Jul 28; 112(30):9346-51.Proc Natl Acad Sci U S A2015-07-13T00:00:002015Vaccine-elicited antibody that neutralizes H5N1 influenza and variants binds the receptor site and polymorphic sites.26226263Chukwuma VU, Hicar MD, Chen X, Nicholas KJ, Joyner A, Kalams SA, Landucci G, Forthal DN, Spearman PW, Crowe JEPloS oneAssociation of VH4-59 Antibody Variable Gene Usage with Recognition of an Immunodominant Epitope on the HIV-1 Gag Protein. PLoS One. 2015; 10(7):e0133509.PLoS One2015-07-30T00:00:002015Association of VH4-59 Antibody Variable Gene Usage with Recognition of an Immunodominant Epitope on the HIV-1 Gag Protein.26301593Callaway JB, Smith SA, Widman DG, McKinnon KP, Scholle F, Sempowski GD, Dittmer DP, Crowe JE, de Silva AM, Ting JPPloS oneSource and Purity of Dengue-Viral Preparations Impact Requirement for Enhancing Antibody to Induce Elevated IL-1? Secretion: A Primary Human Monocyte Model. PLoS One. 2015; 10(8):e0136708.PLoS One2015-08-24T00:00:002015Source and Purity of Dengue-Viral Preparations Impact Requirement for Enhancing Antibody to Induce Elevated IL-1? Secretion: A Primary Human Monocyte Model.26485213Crowe JE, Koff WCExpert review of vaccinesDeciphering the human immunome. Expert Rev Vaccines. 2015; 14(11):1421-5.Expert Rev Vaccines2015-08-24T00:00:002015Deciphering the human immunome.26504196Long F, Fong RH, Austin SK, Chen Z, Klose T, Fokine A, Liu Y, Porta J, Sapparapu G, Akahata W, Doranz BJ, Crowe JE, Diamond MS, Rossmann MGProceedings of the National Academy of Sciences of the United States of AmericaCryo-EM structures elucidate neutralizing mechanisms of anti-chikungunya human monoclonal antibodies with therapeutic activity. Proc Natl Acad Sci U S A. 2015 Nov 10; 112(45):13898-903.Proc Natl Acad Sci U S A2015-10-26T00:00:002015Cryo-EM structures elucidate neutralizing mechanisms of anti-chikungunya human monoclonal antibodies with therapeutic activity.26512092Smith SA, Nivarthi UK, de Alwis R, Kose N, Sapparapu G, Bombardi R, Kahle KM, Pfaff JM, Lieberman S, Doranz BJ, de Silva AM, Crowe JEJournal of virologyDengue Virus prM-Specific Human Monoclonal Antibodies with Virus Replication-Enhancing Properties Recognize a Single Immunodominant Antigenic Site. J Virol. 2016 01 15; 90(2):780-9.J Virol2015-10-28T00:00:002015Dengue Virus prM-Specific Human Monoclonal Antibodies with Virus Replication-Enhancing Properties Recognize a Single Immunodominant Antigenic Site.26553503Fox JM, Long F, Edeling MA, Lin H, van Duijl-Richter MKS, Fong RH, Kahle KM, Smit JM, Jin J, Simmons G, Doranz BJ, Crowe JE, Fremont DH, Rossmann MG, Diamond MSCellBroadly Neutralizing Alphavirus Antibodies Bind an Epitope on E2 and Inhibit Entry and Egress. Cell. 2015 Nov 19; 163(5):1095-1107.Cell2015-11-06T00:00:002015Broadly Neutralizing Alphavirus Antibodies Bind an Epitope on E2 and Inhibit Entry and Egress.11881789Peters TR, Jennings MT, Crowe JEPediatric hematology and oncologyPneumocystis carinii pneumonia in a girl with a midbrain glioma. Pediatr Hematol Oncol. 2002 Mar; 19(2):141-3.Pediatr Hematol Oncol2002-03-01T00:00:002002Pneumocystis carinii pneumonia in a girl with a midbrain glioma.12667209Rock MT, Crowe JEImmunologyIdentification of a novel human leucocyte antigen-A*01-restricted cytotoxic T-lymphocyte epitope in the respiratory syncytial virus fusion protein. Immunology. 2003 Apr; 108(4):474-80.Immunology2003-04-01T00:00:002003Identification of a novel human leucocyte antigen-A*01-restricted cytotoxic T-lymphocyte epitope in the respiratory syncytial virus fusion protein.12667686Weitkamp JH, Kallewaard N, Kusuhara K, Feigelstock D, Feng N, Greenberg HB, Crowe JEJournal of immunological methodsGeneration of recombinant human monoclonal antibodies to rotavirus from single antigen-specific B cells selected with fluorescent virus-like particles. J Immunol Methods. 2003 Apr 01; 275(1-2):223-37.J Immunol Methods2003-04-01T00:00:002003Generation of recombinant human monoclonal antibodies to rotavirus from single antigen-specific B cells selected with fluorescent virus-like particles.12758048Crowe JE, Williams JVPaediatric respiratory reviewsImmunology of viral respiratory tract infection in infancy. Paediatr Respir Rev. 2003 Jun; 4(2):112-9.Paediatr Respir Rev2003-06-01T00:00:002003Immunology of viral respiratory tract infection in infancy.15582654Kallewaard NL, Bowen AL, Crowe JEVirologyCooperativity of actin and microtubule elements during replication of respiratory syncytial virus. Virology. 2005 Jan 05; 331(1):73-81.Virology2005-01-05T00:00:002005Cooperativity of actin and microtubule elements during replication of respiratory syncytial virus.74Professor10Assistant Professor27Clinical Assistant Professor14Associate Professor3Adjunct Associate Professor78Professor Emeritus6Adjunct Professor47Distinguished Service Professor15688286Shaklee JF, Talbot TR, Muldowney JA, Vaughan DE, Butler J, House F, Crowe JE, Smith LH, Edwards KMThe Journal of infectious diseasesSmallpox vaccination does not elevate systemic levels of prothrombotic proteins associated with ischemic cardiac events. J Infect Dis. 2005 Mar 01; 191(5):724-30.J Infect Dis2005-01-25T00:00:002005Smallpox vaccination does not elevate systemic levels of prothrombotic proteins associated with ischemic cardiac events.THOMASMONATHTHOMAS MONATH0.000000000000000.000000000000004859MONATH, THOMASAdjunct Professor15827168Chen X, Rock MT, Hammonds J, Tartaglia J, Shintani A, Currier J, Slike B, Crowe JE, Marovich M, Spearman PJournal of virologyPseudovirion particle production by live poxvirus human immunodeficiency virus vaccine vector enhances humoral and cellular immune responses. J Virol. 2005 May; 79(9):5537-47.J Virol2005-05-01T00:00:002005Pseudovirion particle production by live poxvirus human immunodeficiency virus vaccine vector enhances humoral and cellular immune responses.15993712Weitkamp JH, Lafleur BJ, Greenberg HB, Crowe JEHuman immunologyNatural evolution of a human virus-specific antibody gene repertoire by somatic hypermutation requires both hotspot-directed and randomly-directed processes. Hum Immunol. 2005 Jun; 66(6):666-76.Hum Immunol2005-06-01T00:00:002005Natural evolution of a human virus-specific antibody gene repertoire by somatic hypermutation requires both hotspot-directed and randomly-directed processes.16103146Williams JV, Tollefson SJ, Johnson JE, Crowe JEJournal of virologyThe cotton rat (Sigmodon hispidus) is a permissive small animal model of human metapneumovirus infection, pathogenesis, and protective immunity. J Virol. 2005 Sep; 79(17):10944-51.J Virol2005-09-01T00:00:002005The cotton rat (Sigmodon hispidus) is a permissive small animal model of human metapneumovirus infection, pathogenesis, and protective immunity.16160180Brock SC, Heck JM, McGraw PA, Crowe JEJournal of virologyThe transmembrane domain of the respiratory syncytial virus F protein is an orientation-independent apical plasma membrane sorting sequence. J Virol. 2005 Oct; 79(19):12528-35.J Virol2005-10-01T00:00:002005The transmembrane domain of the respiratory syncytial virus F protein is an orientation-independent apical plasma membrane sorting sequence.Authorship 32054512Authorship 32065224Authorship 32067915Authorship 3215168Authorship 32167210Authorship 3220695Authorship 3221506Authorship 3223146Authorship 3225806Authorship 32272319Authorship 3227537Authorship 3229476Authorship 3231504Authorship 3231672Authorship 323711726748387Hicar MD, Chen X, Kalams SA, Sojar H, Landucci G, Forthal DN, Spearman P, Crowe JEMolecular immunologyLow frequency of broadly neutralizing HIV antibodies during chronic infection even in quaternary epitope targeting antibodies containing large numbers of somatic mutations. Mol Immunol. 2016 Feb; 70:94-103.Mol Immunol2015-12-31T00:00:002015Low frequency of broadly neutralizing HIV antibodies during chronic infection even in quaternary epitope targeting antibodies containing large numbers of somatic mutations.26772634Bates JT, Pickens JA, Schuster JE, Johnson M, Tollefson SJ, Williams JV, Davis NL, Johnston RE, Schultz-Darken N, Slaughter JC, Smith-House F, Crowe JEVaccineImmunogenicity and efficacy of alphavirus-derived replicon vaccines for respiratory syncytial virus and human metapneumovirus in nonhuman primates. Vaccine. 2016 Feb 10; 34(7):950-6.Vaccine2016-01-07T00:00:002016Immunogenicity and efficacy of alphavirus-derived replicon vaccines for respiratory syncytial virus and human metapneumovirus in nonhuman primates.26806128Flyak AI, Shen X, Murin CD, Turner HL, David JA, Fusco ML, Lampley R, Kose N, Ilinykh PA, Kuzmina N, Branchizio A, King H, Brown L, Bryan C, Davidson E, Doranz BJ, Slaughter JC, Sapparapu G, Klages C, Ksiazek TG, Saphire EO, Ward AB, Bukreyev A, Crowe JECellCross-Reactive and Potent Neutralizing Antibody Responses in Human Survivors of Natural Ebolavirus Infection. Cell. 2016 Jan 28; 164(3):392-405.Cell2016-01-21T00:00:002016Cross-Reactive and Potent Neutralizing Antibody Responses in Human Survivors of Natural Ebolavirus Infection.26819055Engelhardt BG, Paczesny S, Jung DK, Daguindau E, Jagasia M, Savani BN, Chinratanalab W, Cornell RF, Goodman S, Greer JP, Kassim AA, Sengsayadeth S, Yoder SM, Rock MT, Crowe JEHaematologicaEarly Th1 immunity promotes immune tolerance and may impair graft-versus-leukemia effect after allogeneic hematopoietic cell transplantation. Haematologica. 2016 05; 101(5):e204-8.Haematologica2016-01-27T00:00:002016Early Th1 immunity promotes immune tolerance and may impair graft-versus-leukemia effect after allogeneic hematopoietic cell transplantation.26819310Ilinykh PA, Shen X, Flyak AI, Kuzmina N, Ksiazek TG, Crowe JE, Bukreyev AJournal of virologyChimeric Filoviruses for Identification and Characterization of Monoclonal Antibodies. J Virol. 2016 Apr; 90(8):3890-3901.J Virol2016-03-28T00:00:002016Chimeric Filoviruses for Identification and Characterization of Monoclonal Antibodies.26908579Bornholdt ZA, Ndungo E, Fusco ML, Bale S, Flyak AI, Crowe JE, Chandran K, Saphire EOmBioHost-Primed Ebola Virus GP Exposes a Hydrophobic NPC1 Receptor-Binding Pocket, Revealing a Target for Broadly Neutralizing Antibodies. mBio. 2016 Feb 23; 7(1):e02154-15.mBio2016-02-23T00:00:002016Host-Primed Ebola Virus GP Exposes a Hydrophobic NPC1 Receptor-Binding Pocket, Revealing a Target for Broadly Neutralizing Antibodies.26950424Thornburg NJ, Zhang H, Bangaru S, Sapparapu G, Kose N, Lampley RM, Bombardi RG, Yu Y, Graham S, Branchizio A, Yoder SM, Rock MT, Creech CB, Edwards KM, Lee D, Li S, Wilson IA, Garc?a-Sastre A, Albrecht RA, Crowe JEThe Journal of clinical investigationH7N9 influenza virus neutralizing antibodies that possess few somatic mutations. J Clin Invest. 2016 Apr 01; 126(4):1482-94.J Clin Invest2016-03-07T00:00:002016H7N9 influenza virus neutralizing antibodies that possess few somatic mutations.26962223Messer WB, Yount BL, Royal SR, de Alwis R, Widman DG, Smith SA, Crowe JE, Pfaff JM, Kahle KM, Doranz BJ, Ibarra KD, Harris E, de Silva AM, Baric RSJournal of virologyFunctional Transplant of a Dengue Virus Serotype 3 (DENV3)-Specific Human Monoclonal Antibody Epitope into DENV1. J Virol. 2016 May 15; 90(10):5090-5097.J Virol2016-04-29T00:00:002016Functional Transplant of a Dengue Virus Serotype 3 (DENV3)-Specific Human Monoclonal Antibody Epitope into DENV1.27044078Willis JR, Finn JA, Briney B, Sapparapu G, Singh V, King H, LaBranche CC, Montefiori DC, Meiler J, Crowe JEProceedings of the National Academy of Sciences of the United States of AmericaLong antibody HCDR3s from HIV-na?ve donors presented on a PG9 neutralizing antibody background mediate HIV neutralization. Proc Natl Acad Sci U S A. 2016 Apr 19; 113(16):4446-51.Proc Natl Acad Sci U S A2016-04-04T00:00:002016Long antibody HCDR3s from HIV-na?ve donors presented on a PG9 neutralizing antibody background mediate HIV neutralization.27058763Clark KB, Hsiao HM, Bassit L, Crowe JE, Schinazi RF, Perng GC, Villinger FVirologyCharacterization of dengue virus 2 growth in megakaryocyte-erythrocyte progenitor cells. Virology. 2016 06; 493:162-72.Virology2016-04-06T00:00:002016Characterization of dengue virus 2 growth in megakaryocyte-erythrocyte progenitor cells.27065089Boyd SD, Crowe JECurrent opinion in immunologyDeep sequencing and human antibody repertoire analysis. Curr Opin Immunol. 2016 06; 40:103-9.Curr Opin Immunol2016-04-08T00:00:002016Deep sequencing and human antibody repertoire analysis.27182833Finn JA, Koehler Leman J, Willis JR, Cisneros A, Crowe JE, Meiler JPloS oneImproving Loop Modeling of the Antibody Complementarity-Determining Region 3 Using Knowledge-Based Restraints. PLoS One. 2016; 11(5):e0154811.PLoS One2016-05-16T00:00:002016Improving Loop Modeling of the Antibody Complementarity-Determining Region 3 Using Knowledge-Based Restraints.27224013Wen X, Pickens J, Mousa JJ, Leser GP, Lamb RA, Crowe JE, Jardetzky TSPloS oneA Chimeric Pneumovirus Fusion Protein Carrying Neutralizing Epitopes of Both MPV and RSV. PLoS One. 2016; 11(5):e0155917.PLoS One2016-05-25T00:00:002016A Chimeric Pneumovirus Fusion Protein Carrying Neutralizing Epitopes of Both MPV and RSV.27303748Boehme KW, Ikizler M, Iskarpatyoti JA, Wetzel JD, Willis J, Crowe JE, LaBranche CC, Montefiori DC, Wilson GJ, Dermody TSmSphereEngineering Recombinant Reoviruses To Display gp41 Membrane-Proximal External-Region Epitopes from HIV-1. mSphere. 2016 May-Jun; 1(3).mSphere2016-05-18T00:00:002016Engineering Recombinant Reoviruses To Display gp41 Membrane-Proximal External-Region Epitopes from HIV-1.27355511Sapparapu G, Czak? R, Alvarado G, Shanker S, Prasad BV, Atmar RL, Estes MK, Crowe JEPLoS pathogensFrequent Use of the IgA Isotype in Human B Cells Encoding Potent Norovirus-Specific Monoclonal Antibodies That Block HBGA Binding. PLoS Pathog. 2016 06; 12(6):e1005719.PLoS Pathog2016-06-29T00:00:002016Frequent Use of the IgA Isotype in Human B Cells Encoding Potent Norovirus-Specific Monoclonal Antibodies That Block HBGA Binding.16845626Rock MT, Yoder SM, Talbot TR, Edwards KM, Crowe JEThe Journal of infectious diseasesCellular immune responses to diluted and undiluted aventis pasteur smallpox vaccine. J Infect Dis. 2006 Aug 15; 194(4):435-43.J Infect Dis2006-07-07T00:00:002006Cellular immune responses to diluted and undiluted aventis pasteur smallpox vaccine.16845627McKinney BA, Reif DM, Rock MT, Edwards KM, Kingsmore SF, Moore JH, Crowe JEThe Journal of infectious diseasesCytokine expression patterns associated with systemic adverse events following smallpox immunization. J Infect Dis. 2006 Aug 15; 194(4):444-53.J Infect Dis2006-07-13T00:00:002006Cytokine expression patterns associated with systemic adverse events following smallpox immunization.14568943Weitkamp JH, Kallewaard N, Kusuhara K, Bures E, Williams JV, LaFleur B, Greenberg HB, Crowe JEJournal of immunology (Baltimore, Md. : 1950)Infant and adult human B cell responses to rotavirus share common immunodominant variable gene repertoires. J Immunol. 2003 Nov 01; 171(9):4680-8.J Immunol2003-11-01T00:00:002003Infant and adult human B cell responses to rotavirus share common immunodominant variable gene repertoires.Authorship 3249627Authorship 3250407Authorship 3250582Authorship 32536813Authorship 3256568Authorship 3258001027402694Cho MJ, Ellebrecht CT, Hammers CM, Mukherjee EM, Sapparapu G, Boudreaux CE, McDonald SM, Crowe JE, Payne ASJournal of immunology (Baltimore, Md. : 1950)Determinants of VH1-46 Cross-Reactivity to Pemphigus Vulgaris Autoantigen Desmoglein 3 and Rotavirus Antigen VP6. J Immunol. 2016 08 15; 197(4):1065-73.J Immunol2016-07-11T00:00:002016Determinants of VH1-46 Cross-Reactivity to Pemphigus Vulgaris Autoantigen Desmoglein 3 and Rotavirus Antigen VP6.27411063Hicar MD, Chen X, Sulli C, Barnes T, Goodman J, Sojar H, Briney B, Willis J, Chukwuma VU, Kalams SA, Doranz BJ, Spearman P, Crowe JEPloS oneHuman Antibodies that Recognize Novel Immunodominant Quaternary Epitopes on the HIV-1 Env Protein. PLoS One. 2016; 11(7):e0158861.PLoS One2016-07-13T00:00:002016Human Antibodies that Recognize Novel Immunodominant Quaternary Epitopes on the HIV-1 Env Protein.27452455Hawman DW, Fox JM, Ashbrook AW, May NA, Schroeder KMS, Torres RM, Crowe JE, Dermody TS, Diamond MS, Morrison TECell reportsPathogenic Chikungunya Virus Evades B Cell Responses to Establish Persistence. Cell Rep. 2016 08 02; 16(5):1326-1338.Cell Rep2016-07-21T00:00:002016Pathogenic Chikungunya Virus Evades B Cell Responses to Establish Persistence.27464688Alvarado G, Crowe JEMethods in molecular biology (Clifton, N.J.)Development of Human Monoclonal Antibodies Against Respiratory Syncytial Virus Using a High Efficiency Human Hybridoma Technique. Methods Mol Biol. 2016; 1442:63-76.Methods Mol Biol2016-01-01T00:00:002016Development of Human Monoclonal Antibodies Against Respiratory Syncytial Virus Using a High Efficiency Human Hybridoma Technique.27508393Verma A, Basile AO, Bradford Y, Kuivaniemi H, Tromp G, Carey D, Gerhard GS, Crowe JE, Ritchie MD, Pendergrass SAPloS onePhenome-Wide Association Study to Explore Relationships between Immune System Related Genetic Loci and Complex Traits and Diseases. 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Cell Host Microbe. 2018 11 14; 24(5):703-716.e3.Cell Host Microbe2018-11-14T00:00:002018HCV Broadly Neutralizing Antibodies Use a CDRH3 Disulfide Motif to Recognize an E2 Glycoprotein Site that Can Be Targeted for Vaccine Design.30439341Kinchen VJ, Zahid MN, Flyak AI, Soliman MG, Learn GH, Wang S, Davidson E, Doranz BJ, Ray SC, Cox AL, Crowe JE, Bjorkman PJ, Shaw GM, Bailey JRCell host & microbeBroadly Neutralizing Antibody Mediated Clearance of Human Hepatitis C Virus Infection. Cell Host Microbe. 2018 11 14; 24(5):717-730.e5.Cell Host Microbe2018-11-14T00:00:002018Broadly Neutralizing Antibody Mediated Clearance of Human Hepatitis C Virus Infection.30455470Kim AS, Austin SK, Gardner CL, Zuiani A, Reed DS, Trobaugh DW, Sun C, Basore K, Williamson LE, Crowe JE, Slifka MK, Fremont DH, Klimstra WB, Diamond MSNature microbiologyProtective antibodies against Eastern equine encephalitis virus bind to epitopes in domains A and B of the E2 glycoprotein. Nat Microbiol. 2019 01; 4(1):187-197.Nat Microbiol2018-11-19T00:00:002018Protective antibodies against Eastern equine encephalitis virus bind to epitopes in domains A and B of the E2 glycoprotein.30455471Goo L, Debbink K, Kose N, Sapparapu G, Doyle MP, Wessel AW, Richner JM, Burgomaster KE, Larman BC, Dowd KA, Diamond MS, Crowe JE, Pierson TCNature microbiologyA protective human monoclonal antibody targeting the West Nile virus E protein preferentially recognizes mature virions. Nat Microbiol. 2019 01; 4(1):71-77.Nat Microbiol2018-11-19T00:00:002018A protective human monoclonal antibody targeting the West Nile virus E protein preferentially recognizes mature virions.30617118Crowe JEJournal of immunology (Baltimore, Md. : 1950)Influenza Virus-Specific Human Antibody Repertoire Studies. J Immunol. 2019 01 15; 202(2):368-373.J Immunol2019-01-15T00:00:002019Influenza Virus-Specific Human Antibody Repertoire Studies.2015-08-31NIH/NIAIDMEILER, JENS2014-09-05Hybrid Methods for Prediction and Design of Novel Human Influenza AntibodiesR56AI1107502011-06-30NIH/NIAIDCROWE, JAMES E2009-07-22Rotavirus VP6 Specific Human IgA AntibodiesR21AI0835742005-07-31NIH/NEICROWE, JAMES E2004-09-30Immunomodulation on the Nanoscale (RMI)PN1EY0165672008-02-28NIH/NIAIDCROWE, JAMES E2003-09-15Cell-Mediated Immune Responses to Vaccinia VirusesR01AI0576612007-06-30NIH/NIAIDCROWE, JAMES E2003-07-01Human T Cells Responses to RSVR01AI0532222003-08-31NIH/NICHDCROWE, JAMES E1997-09-30ONTOGENY OF RSV-SPECIFIC B CELL RESPONSES IN HUMANSR01HD0363112010-02-28NIH/NIAIDCROWE, JAMES E2004-04-01Alphavirus-based Vaccine for Prevention of MPV InfectionR01AI0595972002-08-31NIH/NICHDCROWE, JAMES E1997-09-30ONTOGENY OF RSV-SPECIFIC B CELL RESPONSES IN HUMANSR29HD0363112015-04-30NIH/NIAIDCROWE, JAMES E2010-05-01Virology Training ProgramT32AI0895542016-07-31NIH/NIAIDCROWE, JAMES E2012-08-15Molecular Determinants of Cross-Reactive Antibody Response to Influenza in HumansR01AI1060022015-05-31NIH/NIAIDCROWE, JAMES E2013-06-01Human neutralizing monoclonal antibodies for Rift Valley fever virusR21AI1038342009-05-31NIH/NIAIDCROWE, JAMES E2004-06-15Human Antibody Responses to RotavirusR01AI0579332020-01-31NIH/NIAIDCROWE, JAMES E2015-02-10Structural and functional basis of ultra potent CHKV neutralization by human mAbsR01AI1148162021-12-31NIH/NIAIDCROWE, JAMES E2017-01-01Human neutralizing antibodies for Zika virusR01AI1278282023-10-31NIH/NIAIDBUKREYEV, ALEXANDER2018-11-01Epitope-Based Design and Modified RNA Platform for Bivalent Marburgvirus VaccineR01AI1416612003-08-31NIH/NIAIDCROWE, JAMES E2000-09-15HUMAN MONOCLONAL ANTIBODIES THAT NEUTRALIZE VACCINIAU01AI0485122011-03-03NIH/NCRRCROWE, JAMES E2010-03-04Multi-Laser Flow Cytometer for Polychromatic AnalysisS10RR0279772020-04-30NIH/NIAIDCROWE, JAMES E2015-05-01Structure based design of antibodies and vaccinesU19AI1179052010-07-31NIH/NIACROWE, JAMES E2007-09-30Respiratory Syncytial Virus Nanoparticle VaccinesR21AG0303212006-08-31NIH/NIAIDCROWE, JAMES E2002-09-01Novel methods for generation of human B cell hybridomasR01AI0486772013-02-28NIH/NIAIDCROWE, JAMES E2008-03-15Clonal Analysis of the Human B Cell Response to HIVU01AI0784072005-06-30NIH/FICCROWE, JAMES E2002-08-15Epitope Specificity of RSV Nucleoprotein-Specific T Cel*R03TW0014972005-03-31NIH/NCRRCROWE, JAMES E2004-04-01High Throughput Flow Cytometry SorterS10RR0190322003-08-31NIH/NIDCRCROWE, JAMES E2000-09-01RESPIRATORY VIRUS NEUTRALIZATION BY INTRACELLULAR ABR21DE014039Principal InvestigatorPrincipal InvestigatorCo-Principal InvestigatorPrincipal InvestigatorPrincipal InvestigatorPrincipal InvestigatorPrincipal InvestigatorPrincipal InvestigatorCo-Principal InvestigatorPrincipal InvestigatorPrincipal InvestigatorPrincipal InvestigatorPrincipal InvestigatorPrincipal InvestigatorPrincipal InvestigatorPrincipal InvestigatorPrincipal InvestigatorPrincipal InvestigatorPrincipal InvestigatorPrincipal InvestigatorPrincipal InvestigatorPrincipal InvestigatorPrincipal InvestigatorPrincipal InvestigatorD000939Chemicals & DrugsPhenomena2476840.805501EpitopesDepartment of MedicineDepartment of PediatricsDepartment of Molecular Virology & MicrobiologyDepartment of RadiologyDepartment of UrologyPediatrics-Tropical MedicineRadiologyUrologyMedicine-Infectious DiseaseMolecular Virology & MicrobiologyPediatrics-Infectious DiseasesBaylor College of MedicineKARLASEPULVEDAKARLA SEPULVEDA0.000000000000000.000000000000001496SEPULVEDA, KARLAProfessorJKANJ KAN0.000000000000000.000000000000001940KAN, JProfessor29.69560.00482711946research areas0.7160840.028902517coauthor of780.63656.329160similar to11387selected publicationsMARYESTESMARY ESTES0.000000000000000.000000000000002318ESTES, MARYDistinguished Service ProfessorFLORMUNOZ-RIVASFLOR MUNOZ-RIVAS0.000000000000000.000000000000002002MUNOZ-RIVAS, FLORAssociate ProfessorDAVIDHODAVID HO29.71079220000000-95.40005120000000411HO, DAVIDClinical Assistant ProfessorPEDROPIEDRAPEDRO PIEDRA0.000000000000000.000000000000003206PIEDRA, PEDROProfessorROBERTATMARROBERT ATMAR0.000000000000000.000000000000003695ATMAR, ROBERTProfessorRICHARDSTRAXRICHARD STRAX0.000000000000000.000000000000004532STRAX, RICHARDProfessor EmeritusMUZAMMILHANIFMUZAMMIL HANIF0.000000000000000.000000000000001636HANIF, MUZAMMILAssistant ProfessorAuthorship 94159112Authorship 94159311Authorship 941949930642974Long F, Doyle M, Fernandez E, Miller AS, Klose T, Sevvana M, Bryan A, Davidson E, Doranz BJ, Kuhn RJ, Diamond MS, Crowe JE, Rossmann MGProceedings of the National Academy of Sciences of the United States of AmericaStructural basis of a potent human monoclonal antibody against Zika virus targeting a quaternary epitope. Proc Natl Acad Sci U S A. 2019 01 29; 116(5):1591-1596.Proc Natl Acad Sci U S A2019-01-14T00:00:002019Structural basis of a potent human monoclonal antibody against Zika virus targeting a quaternary epitope.30726740Salazar V, Jagger BW, Mongkolsapaya J, Burgomaster KE, Dejnirattisai W, Winkler ES, Fernandez E, Nelson CA, Fremont DH, Pierson TC, Crowe JE, Screaton GR, Diamond MSCell reportsDengue and Zika Virus Cross-Reactive Human Monoclonal Antibodies Protect against Spondweni Virus Infection and Pathogenesis in Mice. Cell Rep. 2019 02 05; 26(6):1585-1597.e4.Cell Rep2019-02-05T00:00:002019Dengue and Zika Virus Cross-Reactive Human Monoclonal Antibodies Protect against Spondweni Virus Infection and Pathogenesis in Mice.30738170Engelhardt BG, Savani U, Jung DK, Powers AC, Jagasia M, Chen H, Winnick JJ, Tamboli RA, Crowe JE, Abumrad NNBiology of blood and marrow transplantation : journal of the American Society for Blood and Marrow TransplantationNew-Onset Post-Transplant Diabetes Mellitus after Allogeneic Hematopoietic Cell Transplant Is Initiated by Insulin Resistance, Not Immunosuppressive Medications. Biol Blood Marrow Transplant. 2019 06; 25(6):1225-1231.Biol Blood Marrow Transplant2019-02-07T00:00:002019New-Onset Post-Transplant Diabetes Mellitus after Allogeneic Hematopoietic Cell Transplant Is Initiated by Insulin Resistance, Not Immunosuppressive Medications.RICHARDWENDT IIIRICHARD WENDT III0.000000000000000.000000000000002988WENDT III, RICHARDAdjunct Associate ProfessorZBIGNIEWSTAROSOLSKIZBIGNIEW STAROSOLSKI0.000000000000000.000000000000004831STAROSOLSKI, ZBIGNIEWAssociate ProfessorAuthorship 9440891530728263Williamson LE, Flyak AI, Kose N, Bombardi R, Branchizio A, Reddy S, Davidson E, Doranz BJ, Fusco ML, Saphire EO, Halfmann PJ, Kawaoka Y, Piper AE, Glass PJ, Crowe JEJournal of virologyEarly Human B Cell Response to Ebola Virus in Four U.S. Survivors of Infection. J Virol. 2019 04 15; 93(8).J Virol2019-04-03T00:00:002019Early Human B Cell Response to Ebola Virus in Four U.S. Survivors of Infection.Authorship 944783530967877Dong J, Finn JA, Larsen PA, Smith TPL, Crowe JEFrontiers in immunologyStructural Diversity of Ultralong CDRH3s in Seven Bovine Antibody Heavy Chains. Front Immunol. 2019; 10:558.Front Immunol2019-03-22T00:00:002019Structural Diversity of Ultralong CDRH3s in Seven Bovine Antibody Heavy Chains.Authorship 9452381130996276King LB, West BR, Moyer CL, Gilchuk P, Flyak A, Ilinykh PA, Bombardi R, Hui S, Huang K, Bukreyev A, Crowe JE, Saphire EONature communicationsCross-reactive neutralizing human survivor monoclonal antibody BDBV223 targets the ebolavirus stalk. Nat Commun. 2019 04 17; 10(1):1788.Nat Commun2019-04-17T00:00:002019Cross-reactive neutralizing human survivor monoclonal antibody BDBV223 targets the ebolavirus stalk.Authorship 9467021031068427Colbert MD, Flyak AI, Ogega CO, Kinchen VJ, Massaccesi G, Hernandez M, Davidson E, Doranz BJ, Cox AL, Crowe JE, Bailey JRJournal of virologyBroadly Neutralizing Antibodies Targeting New Sites of Vulnerability in Hepatitis C Virus E1E2. J Virol. 2019 07 15; 93(14).J Virol2019-06-28T00:00:002019Broadly Neutralizing Antibodies Targeting New Sites of Vulnerability in Hepatitis C Virus E1E2.Authorship 1273361Authorship 12781210Authorship 1281214Authorship 1288126Authorship 1291291723799651Stone JW, Thornburg NJ, Blum DL, Kuhn SJ, Wright DW, Crowe JENanotechnologyGold nanorod vaccine for respiratory syncytial virus. 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Ann N Y Acad Sci. 2020 02; 1462(1):14-26.Ann N Y Acad Sci2019-10-28T00:00:002019Vaccine innovations for emerging infectious diseases-a symposium report.true1ProfessorProfessortrue1Distinguished Service ProfessorDistinguished Service ProfessorAuthorship 111915431897567Ho BJ, Crowe JE, Dorfman SR, Camp EA, Yusuf S, Shenoi RPPediatric radiologyCorrelation of clinical and chest radiograph findings in pediatric submersion cases. 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MAbs. 2022 Jan-Dec; 14(1):2068212.MAbs2022-01-01T00:00:002022The human antibody sequence space and structural design of the V, J regions, and CDRH3 with Rosetta.35578733Suryadevara N, Gilchuk P, Zost SJ, Mittal N, Zhao LL, Crowe JE, Carnahan RHSTAR protocolsReal-time cell analysis: A high-throughput approach for testing SARS-CoV-2 antibody neutralization and escape. STAR Protoc. 2022 06 17; 3(2):101387.STAR Protoc2022-04-22T00:00:002022Real-time cell analysis: A high-throughput approach for testing SARS-CoV-2 antibody neutralization and escape.35583347Fowler BD, Kose N, Reidy JX, Handal LS, Skaar EP, Crowe JEInfection and immunityHuman Monoclonal Antibodies to Escherichia coli Outer Membrane Protein A Porin Domain Cause Aggregation but Do Not Alter In Vivo Bacterial Burdens in a Murine Sepsis Model. 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Nat Commun. 2022 06 16; 13(1):3466.Nat Commun2022-06-16T00:00:002022Single-cell profiling of the antigen-specific response to BNT162b2 SARS-CoV-2 RNA vaccine.KHALILETTAYEBIKHALIL ETTAYEBI17787ETTAYEBI, KHALILInstructorAuthorship 104984237Authorship 10498371835780162Case JB, Mackin S, Errico JM, Chong Z, Madden EA, Whitener B, Guarino B, Schmid MA, Rosenthal K, Ren K, Dang HV, Snell G, Jung A, Droit L, Handley SA, Halfmann PJ, Kawaoka Y, Crowe JE, Fremont DH, Virgin HW, Loo YM, Esser MT, Purcell LA, Corti D, Diamond MSNature communicationsResilience of S309 and AZD7442 monoclonal antibody treatments against infection by SARS-CoV-2 Omicron lineage strains. 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Chest. 2022 11; 162(5):982-994.Chest2022-07-01T00:00:002022Neutralizing COVID-19 Convalescent Plasma in Adults Hospitalized With COVID-19: A Blinded, Randomized, Placebo-Controlled Trial.Authorship 10508411635857623Nkolola JP, Yu J, Wan H, Chang A, McMahan K, Anioke T, Jacob-Dolan C, Powers O, Ye T, Chandrashekar A, Sellers D, Barrett J, Loo YM, Esser MT, Carnahan RH, Crowe JE, Barouch DHScience translational medicineA bivalent SARS-CoV-2 monoclonal antibody combination does not affect the immunogenicity of a vector-based COVID-19 vaccine in macaques. Sci Transl Med. 2022 10 05; 14(665):eabo6160.Sci Transl Med2022-10-05T00:00:002022A bivalent SARS-CoV-2 monoclonal antibody combination does not affect the immunogenicity of a vector-based COVID-19 vaccine in macaques.true1InstructorInstructorAuthorship 1202637true1Associate ProfessorAssociate ProfessorAuthorship 106135341Authorship 105592636Authorship 10625643Authorship 10617656Authorship 105539617Authorship 10559498Authorship 1058974636708513Pilewski KA, Wall S, Richardson SI, Manamela NP, Clark K, Hermanus T, Binshtein E, Venkat R, Sautto GA, Kramer KJ, Shiakolas AR, Setliff I, Salas J, Mapengo RE, Suryadevara N, Brannon JR, Beebout CJ, Parks R, Raju N, Frumento N, Walker LM, Fechter EF, Qin JS, Murji AA, Janowska K, Thakur B, Lindenberger J, May AJ, Huang X, Sammour S, Acharya P, Carnahan RH, Ross TM, Haynes BF, Hadjifrangiskou M, Crowe JE, Bailey JR, Kalams S, Morris L, Georgiev ISCell reportsFunctional HIV-1/HCV cross-reactive antibodies isolated from a chronically co-infected donor. 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Front Immunol. 2022; 13:1040836.Front Immunol2022-10-25T00:00:002022Cross-reactive neutralizing human monoclonal antibodies mapping to variable antigenic sites on the norovirus major capsid protein.36477260Fischer MFS, Crowe JE, Meiler JPLoS computational biologyComputational epitope mapping of class I fusion proteins using low complexity supervised learning methods. PLoS Comput Biol. 2022 12; 18(12):e1010230.PLoS Comput Biol2022-12-07T00:00:002022Computational epitope mapping of class I fusion proteins using low complexity supervised learning methods.36516766Raju N, Zhan X, Das S, Karwal L, Dean HJ, Crowe JE, Carnahan RH, Georgiev ISCell reportsNeutralization fingerprinting technology for characterizing polyclonal antibody responses to dengue vaccines. 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Gene Ther. 2023 Feb 02.Gene Ther2023-02-02T00:00:002023Antibody-based protection against respiratory syncytial virus in mice and their offspring through vectored immunoprophylaxis.Authorship 10649071336853802Parrington HM, Kose N, Armstrong E, Handal L, Diaz S, Reidy J, Dong J, Stewart-Jones GB, Shrivastava-Ranjan P, Jain S, Albari?o CG, Carnahan RH, Crowe JEJCI insightPotently neutralizing human mAbs against the zoonotic pararubulavirus Sosuga virus. JCI Insight. 2023 04 24; 8(8).JCI Insight2023-04-24T00:00:002023Potently neutralizing human mAbs against the zoonotic pararubulavirus Sosuga virus.true1ProfessorProfessorAuthorship 1066134836961925Williamson LE, Bandyopadhyay A, Bailey K, Sirohi D, Klose T, Julander JG, Kuhn RJ, Crowe JEProceedings of the National Academy of Sciences of the United States of AmericaStructural constraints link differences in neutralization potency of human anti-Eastern equine encephalitis virus monoclonal antibodies. Proc Natl Acad Sci U S A. 2023 03 28; 120(13):e2213690120.Proc Natl Acad Sci U S A2023-03-24T00:00:002023Structural constraints link differences in neutralization potency of human anti-Eastern equine encephalitis virus monoclonal antibodies.Authorship 10668532236971354Engdahl TB, Binshtein E, Brocato RL, Kuzmina NA, Principe LM, Kwilas SA, Kim RK, Chapman NS, Porter MS, Guardado-Calvo P, Rey FA, Handal LS, Diaz SM, Zagol-Ikapitte IA, Tran MH, McDonald WH, Meiler J, Reidy JX, Trivette A, Bukreyev A, Hooper JW, Crowe JEeLifeAntigenic mapping and functional characterization of human New World hantavirus neutralizing antibodies. Elife. 2023 03 27; 12.Elife2023-03-27T00:00:002023Antigenic mapping and functional characterization of human New World hantavirus neutralizing antibodies.Authorship 106776711Authorship 106897124Authorship 106896912Authorship 1067766237029694Rolsma SL, Yoder SM, Nargi RS, Brady E, Jimenez-Truque N, Thomsen I, Kontos M, Carnahan RH, Sutton RE, Armstrong E, Dally L, Crowe JE, Edwards KM, Creech CBJournal of the Pediatric Infectious Diseases SocietyDevelopment of a Kinetic ELISA and Reactive B Cell Frequency Assay to Detect Respiratory Syncytial Virus Pre-Fusion F Protein-Specific Immune Responses in Infants. 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Cell Rep. 2023 04 25; 42(4):112370.Cell Rep2023-04-07T00:00:002023Systematic analysis of human antibody response to ebolavirus glycoprotein shows high prevalence of neutralizing public clonotypes.37033983Skinner NE, Ogega CO, Frumento N, Clark KE, Yegnasubramanian S, Schuebel K, Meyers J, Gupta A, Wheelan S, Cox AL, Crowe JE, Ray SC, Bailey JRFrontiers in immunologyConvergent antibody responses are associated with broad neutralization of hepatitis C virus. Front Immunol. 2023; 14:1135841.Front Immunol2023-03-24T00:00:002023Convergent antibody responses are associated with broad neutralization of hepatitis C virus.true1Adjunct Associate ProfessorAdjunct Associate Professortrue1Adjunct ProfessorAdjunct Professortrue1Clinical Assistant ProfessorClinical Assistant ProfessorAuthorship 10698626Authorship 106950612Authorship 1069333837131834Bukreyev A, Ilinykh P, Huang K, Gunn B, Kuzmina N, Gilchuk P, Alter G, Crowe JResearch squareAntiviral protection by antibodies targeting the glycan cap of Ebola virus glycoprotein requires activation of the complement system. Res Sq. 2023 Apr 21.Res Sq2023-04-21T00:00:002023Antiviral protection by antibodies targeting the glycan cap of Ebola virus glycoprotein requires activation of the complement system.37180140Skinner NE, Ogega CO, Frumento N, Clark KE, Paul H, Yegnasubramanian S, Schuebel K, Meyers J, Gupta A, Wheelan S, Cox AL, Crowe JE, Ray SC, Bailey JRFrontiers in immunologyCorrigendum: Convergent antibody responses are associated with broad neutralization of hepatitis C virus. Front Immunol. 2023; 14:1201033.Front Immunol2023-04-25T00:00:002023Corrigendum: Convergent antibody responses are associated with broad neutralization of hepatitis C virus.37196061Raju S, Adams LJ, Earnest JT, Warfield K, Vang L, Crowe JE, Fremont DH, Diamond MSScience translational medicineA chikungunya virus-like particle vaccine induces broadly neutralizing and protective antibodies against alphaviruses in humans. Sci Transl Med. 2023 05 17; 15(696):eade8273.Sci Transl Med2023-05-17T00:00:002023A chikungunya virus-like particle vaccine induces broadly neutralizing and protective antibodies against alphaviruses in humans.Authorship 10732586Authorship 1072136737322112Stass R, Engdahl TB, Chapman NS, Wolters RM, Handal LS, Diaz SM, Crowe JE, Bowden TANature microbiologyMechanistic basis for potent neutralization of Sin Nombre hantavirus by a human monoclonal antibody. Nat Microbiol. 2023 07; 8(7):1293-1303.Nat Microbiol2023-06-15T00:00:002023Mechanistic basis for potent neutralization of Sin Nombre hantavirus by a human monoclonal antibody.37393178Albar A, Sher AC, Rosenfeld S, Ditzler M, Kraus S, Crowe J, Sangi-Haghpeykar H, Kan JHAcademic radiologyImproved Identification of Adolescent Hip Dysplasia Using a Screening Method Based on Lateral Center Edge Angle Measurements. Acad Radiol. 2023 10; 30(10):2140-2146.Acad Radiol2023-06-29T00:00:002023Improved Identification of Adolescent Hip Dysplasia Using a Screening Method Based on Lateral Center Edge Angle Measurements.Authorship 1075727737495594McMillen CM, Chapman NS, Hoehl RM, Skvarca LB, Schwarz MM, Handal LS, Crowe JE, Hartman ALNature communicationsA highly potent human neutralizing antibody prevents vertical transmission of Rift Valley fever virus in a rat model. Nat Commun. 2023 07 26; 14(1):4507.Nat Commun2023-07-26T00:00:002023A highly potent human neutralizing antibody prevents vertical transmission of Rift Valley fever virus in a rat model.Authorship 107838213Authorship 10786191137516111Wen X, Suryadevara N, Kose N, Liu J, Zhan X, Handal LS, Williamson LE, Trivette A, Carnahan RH, Jardetzky TS, Crowe JECell host & microbePotent cross-neutralization of respiratory syncytial virus and human metapneumovirus through a structurally conserved antibody recognition mode. Cell Host Microbe. 2023 08 09; 31(8):1288-1300.e6.Cell Host Microbe2023-07-28T00:00:002023Potent cross-neutralization of respiratory syncytial virus and human metapneumovirus through a structurally conserved antibody recognition mode.37704627Chapman NS, Hulswit RJG, Westover JLB, Stass R, Paesen GC, Binshtein E, Reidy JX, Engdahl TB, Handal LS, Flores A, Gowen BB, Bowden TA, Crowe JENature communicationsMultifunctional human monoclonal antibody combination mediates protection against Rift Valley fever virus at low doses. Nat Commun. 2023 09 13; 14(1):5650.Nat Commun2023-09-13T00:00:002023Multifunctional human monoclonal antibody combination mediates protection against Rift Valley fever virus at low doses.Authorship 10797542337749254Hou YJ, Chiba S, Leist SR, Meganck RM, Martinez DR, Sch?fer A, Catanzaro NJ, Sontake V, West A, Edwards CE, Yount B, Lee RE, Gallant SC, Zost SJ, Powers J, Adams L, Kong EF, Mattocks M, Tata A, Randell SH, Tata PR, Halfmann P, Crowe JE, Kawaoka Y, Baric RSNature microbiologyHost range, transmissibility and antigenicity of a pangolin coronavirus. Nat Microbiol. 2023 10; 8(10):1820-1833.Nat Microbiol2023-09-25T00:00:002023Host range, transmissibility and antigenicity of a pangolin coronavirus.Authorship 10817604Authorship 1081819837858466Santos RI, Ilinykh PA, Pietzsch CA, Ronk AJ, Huang K, Kuzmina NA, Zhou F, Crowe JE, Bukreyev ACell reportsBlocking of ebolavirus spread through intercellular connections by an MPER-specific antibody depends on BST2/tetherin. Cell Rep. 2023 10 31; 42(10):113254.Cell Rep2023-10-17T00:00:002023Blocking of ebolavirus spread through intercellular connections by an MPER-specific antibody depends on BST2/tetherin.37849399Powers AM, Williamson LE, Carnahan RH, Crowe JE, Hyde JL, Jonsson CB, Nasar F, Weaver SCThe Journal of infectious diseasesDeveloping a Prototype Pathogen Plan and Research Priorities for the Alphaviruses. J Infect Dis. 2023 10 18; 228(Suppl 6):S414-S426.J Infect Dis2023-10-18T00:00:002023Developing a Prototype Pathogen Plan and Research Priorities for the Alphaviruses.Authorship 10824221737909048Munt JE, Henein S, Adams C, Young E, Hou YJ, Conrad H, Zhu D, Dong S, Kose N, Yount B, Meganck RM, Tse LPV, Kuan G, Balmaseda A, Ricciardi MJ, Watkins DI, Crowe JE, Harris E, DeSilva AM, Baric RSCell host & microbeHomotypic antibodies target novel E glycoprotein domains after natural DENV 3 infection/vaccination. Cell Host Microbe. 2023 11 08; 31(11):1850-1865.e5.Cell Host Microbe2023-10-30T00:00:002023Homotypic antibodies target novel E glycoprotein domains after natural DENV 3 infection/vaccination.Authorship 108326413Authorship 10833553037935199Wall SC, Suryadevara N, Kim C, Shiakolas AR, Holt CM, Irbe EB, Wasdin PT, Suresh YP, Binshtein E, Chen EC, Zost SJ, Canfield E, Crowe JE, Thompson-Arildsen MA, Sheward DJ, Carnahan RH, Georgiev ISCell reports. MedicineSARS-CoV-2 antibodies from children exhibit broad neutralization and belong to adult public clonotypes. Cell Rep Med. 2023 11 21; 4(11):101267.Cell Rep Med2023-11-06T00:00:002023SARS-CoV-2 antibodies from children exhibit broad neutralization and belong to adult public clonotypes.37923717Streblow DN, Hirsch AJ, Stanton JJ, Lewis AD, Colgin L, Hessell AJ, Kreklywich CN, Smith JL, Sutton WF, Chauvin D, Woo J, Bimber BN, LeBlanc CN, Acharya SN, O'Roak BJ, Sardar H, Sajadi MM, Tehrani ZR, Walter MR, Martinez-Sobrido L, Kobie JJ, Reader RJ, Olstad KJ, Hobbs TR, Saphire EO, Schendel SL, Carnahan RH, Knoch J, Branco LM, Crowe JE, Van Rompay KKA, Lovalenti P, Forthal DN, Haigwood NLNature communicationsAerosol delivery of SARS-CoV-2 human monoclonal antibodies in macaques limits viral replication and lung pathology. Nat Commun. 2023 11 03; 14(1):7062.Nat Commun2023-11-03T00:00:002023Aerosol delivery of SARS-CoV-2 human monoclonal antibodies in macaques limits viral replication and lung pathology.Authorship 143114Authorship 1479010Authorship 160902Authorship 10843401338039973Adams LJ, VanBlargan LA, Liu Z, Gilchuk P, Zhao H, Chen RE, Raju S, Chong Z, Whitener BM, Shrihari S, Jethva PN, Gross ML, Crowe JE, Whelan SPJ, Diamond MS, Fremont DHCell reports. MedicineA broadly reactive antibody targeting the N-terminal domain of SARS-CoV-2 spike confers Fc-mediated protection. 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J Immunol. 2024 Mar 15.J Immunol2024-03-15T00:00:002024Potent HPIV3-neutralizing IGHV5-51 Antibodies Identified from Multiple Individuals Show L Chain and CDRH3 Promiscuity.true1Professor EmeritusProfessor EmeritusAuthorship 196465Authorship 24393Authorship 183266Authorship 218915Authorship 1952424Authorship 24344Authorship 315317Authorship 353255Authorship 392542Authorship 39466Authorship 280033Authorship 397186Authorship 305091Authorship 299103Authorship 313393Authorship 460435Authorship 14122324Authorship 14142711Authorship 1417976Authorship 14224913Authorship 1422767Authorship 1423462Authorship 1431381424351207Alonas E, Lifland AW, Gudheti M, Vanover D, Jung J, Zurla C, Kirschman J, Fiore VF, Douglas A, Barker TH, Yi H, Wright ER, Crowe JE, Santangelo PJACS nanoCombining single RNA sensitive probes with subdiffraction-limited and live-cell imaging enables the characterization of virus dynamics in cells. 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Proc Natl Acad Sci U S A. 2014 Feb 04; 111(5):1939-44.Proc Natl Acad Sci U S A2014-01-02T00:00:002014Dengue virus envelope protein domain I/II hinge determines long-lived serotype-specific dengue immunity.24421336Fibriansah G, Tan JL, Smith SA, de Alwis AR, Ng TS, Kostyuchenko VA, Ibarra KD, Wang J, Harris E, de Silva A, Crowe JE, Lok SMEMBO molecular medicineA potent anti-dengue human antibody preferentially recognizes the conformation of E protein monomers assembled on the virus surface. EMBO Mol Med. 2014 03; 6(3):358-71.EMBO Mol Med2014-01-13T00:00:002014A potent anti-dengue human antibody preferentially recognizes the conformation of E protein monomers assembled on the virus surface.24445883Bisset GS, Crowe JPediatric radiologyDiagnostic errors in interpretation of pediatric musculoskeletal radiographs at common injury sites. 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PLoS One. 2014; 9(6):e100839.PLoS One2014-06-23T00:00:002014Tissue-specific expressed antibody variable gene repertoires.Authorship 6440910Authorship 472489Authorship 480862Authorship 691236Authorship 149007824920804Dulek DE, Newcomb DC, Toki S, Goliniewska K, Cephus J, Reiss S, Bates JT, Crowe JE, Boyd KL, Moore ML, Zhou W, Peebles RSJournal of virologySTAT4 deficiency fails to induce lung Th2 or Th17 immunity following primary or secondary respiratory syncytial virus (RSV) challenge but enhances the lung RSV-specific CD8+ T cell immune response to secondary challenge. 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