JINWANGJIN WANG0.000000000000000.000000000000001912WANG, JINchemical biology, sensors and probes, drug discovery, antibody drug conjugatesProfessorplugins:TwitterTwitterprns:awardConferredByaward conferred byprns:coAuthorOfcoauthor ofprns:endDateend dateFaculty Rankprns:fullNamefull nameprns:grantAwardedBygrant awarded byprns:hasAuthorListauthor listprns:hasFacultyRankhas faculty rankprns:hasNetworkhas networkprns:hasPublicationVenuepublished inprns:informationResourceReferenceinformation resource referenceprns:isPrimaryPositionis primary positionprns:latitudelatitudeprns:longitudelongitudeprns:mainImagephotoprns:maxWeightmaximum weightprns:medlineTAjournal title abbreviationprns:meshDescriptorUIMeSH DescriptorUIprns:meshSemanticGroupNameMeSH semantic group nameprns:minWeightminimum weightprns:numberOfAuthorsnumber of authorsprns:numberOfConnectionsnumber of connectionsprns:numberOfPublicationsnumber of publicationsprns:personIdPerson IDprns:personInPrimaryPositionperson in primary positionprns:physicalNeighborOfphysical neighborprns:pluginSearchableDataProfilesRNS Plugin Searchable Dataprns:positionInDepartmentposition in departmentprns:positionInDivisionposition in divisionprns:predicateNodepredicate nodeprns:principalInvestigatorNameprincipal investigator nameprns:publicationDatepublication dateprns:similarTosimilar toprns:sortOrdersort orderprns:startDatestart dateprns:trainingAtOrganizationeducational organizationprns:trainingLocationtraining locationprns:uniquenessWeightuniqueness weightprns:yearyearAcademic ArticleArticleDocumentbibo:pmidPubMed IdentifierAddressvivo:address1address line 1vivo:addressCitycityvivo:addressPostalCodepostal codevivo:addressStatestate or provinceAgreementvivo:authorInAuthorshipselected publicationsvivo:authorRankauthor rank in publicationAuthorshipvivo:awardOrHonorawards and honorsAward or Honor Receiptvivo:degreeEarneddegree earnedDepartmentDivisionvivo:educationalTrainingeducation and trainingEducational Trainingvivo:freetextKeywordkeywordsGrantvivo:hasResearchArearesearch areasvivo:hasResearcherRoleresearch activitiesvivo:hrJobTitleHR job titleInformation Resourcevivo:linkedAuthorlinked authorvivo:linkedInformationResourcelinked information resourcevivo:mailingAddressmailing addressvivo:majorFieldmajor field of degreevivo:personInPositionpositionsPositionvivo:positionInOrganizationposition in organizationvivo:preferredTitlepreferred titleResearcher Rolevivo:researcherRoleOfresearcher role ofRolevivo:roleContributesTocontributes tovivo:sponsorAwardIdsponsor award idrdf:predicatepredicaterdf:typetyperdfs:labellabelConceptAgentfoaf:firstNamefirst namefoaf:lastNamelast nameOrganizationPersonAuthorship 826651Authorship 111561Authorship 143252Authorship 234561Authorship 28456111Assistant Professor - SHPGynecological Oncology & Reproductive MedicineLeukemiaMolecular & Cellular OncologySchool of Health ProfessionsMD AndersonMIEN-CHIEHUNGMIEN-CHIE HUNG8427HUNG, MIEN-CHIEProfessorANIRBANMAITRAANIRBAN MAITRA9915MAITRA, ANIRBANProfessorHAGOP MKANTARJIANHAGOP M KANTARJIAN8501KANTARJIAN, HAGOP MProfessorANIL KSOODANIL K SOOD9048SOOD, ANIL KProfessorAuthorship 576414Authorship 668792Authorship 716218Authorship 725851Authorship 902863Authorship 923021CPRIT20152011CPRIT ScholarAuthorship 2812954Authorship 2812966Authorship 28129713Authorship 2812985Authorship 28129913Authorship 28130011Authorship 2813015One Baylor PlazaHouston, 77030TX26420603Zhang Y, Wang Y, Zhang C, Wang J, Pan D, Liu J, Feng FACS applied materials & interfacesTargeted Gene Delivery to Macrophages by Biodegradable Star-Shaped Polymers. ACS Appl Mater Interfaces. 2016 Feb 17; 8(6):3719-24.ACS Appl Mater Interfaces2015-10-01T00:00:002015Targeted Gene Delivery to Macrophages by Biodegradable Star-Shaped Polymers.26212543Liu X, Lu Y, Guan X, Dong B, Chavan H, Wang J, Zhang Y, Krishnamurthy P, Li FBiochemical pharmacologyMetabolomics reveals the formation of aldehydes and iminium in gefitinib metabolism. Biochem Pharmacol. 2015 Sep 01; 97(1):111-21.Biochem Pharmacol2015-07-23T00:00:002015Metabolomics reveals the formation of aldehydes and iminium in gefitinib metabolism.26606171Chen J, Jiang X, Carroll S, Huang J, Wang JOrganic lettersTheoretical and Experimental Investigation of Thermodynamics and Kinetics of Thiol-Michael Addition Reactions: A Case Study of Reversible Fluorescent Probes for Glutathione Imaging in Single Cells. Org Lett. 2015 Dec 18; 17(24):5978-5981.Org Lett2015-11-25T00:00:002015Theoretical and Experimental Investigation of Thermodynamics and Kinetics of Thiol-Michael Addition Reactions: A Case Study of Reversible Fluorescent Probes for Glutathione Imaging in Single Cells.26431029Song X, Zhang C, Zhao M, Chen H, Liu X, Chen J, Lonard DM, Qin L, Xu J, Wang X, Li F, O'Malley BW, Wang JPloS oneSteroid Receptor Coactivator-3 (SRC-3/AIB1) as a Novel Therapeutic Target in Triple Negative Breast Cancer and Its Inhibition with a Phospho-Bufalin Prodrug. PLoS One. 2015; 10(10):e0140011.PLoS One2015-10-02T00:00:002015Steroid Receptor Coactivator-3 (SRC-3/AIB1) as a Novel Therapeutic Target in Triple Negative Breast Cancer and Its Inhibition with a Phospho-Bufalin Prodrug.26287601Qin L, Xu Y, Xu Y, Ma G, Liao L, Wu Y, Li Y, Wang X, Wang X, Jiang J, Wang J, Xu JOncotargetNCOA1 promotes angiogenesis in breast tumors by simultaneously enhancing both HIF1a- and AP-1-mediated VEGFa transcription. Oncotarget. 2015 Sep 15; 6(27):23890-904.Oncotarget2015-09-15T00:00:002015NCOA1 promotes angiogenesis in breast tumors by simultaneously enhancing both HIF1a- and AP-1-mediated VEGFa transcription.23924216Xu J, Luft JC, Yi X, Tian S, Owens G, Wang J, Johnson A, Berglund P, Smith J, Napier ME, DeSimone JMMolecular pharmaceuticsRNA replicon delivery via lipid-complexed PRINT protein particles. Mol Pharm. 2013 Sep 03; 10(9):3366-74.Mol Pharm2013-08-21T00:00:002013RNA replicon delivery via lipid-complexed PRINT protein particles.74Professor10Assistant Professor14Associate Professor78Professor Emeritus47Distinguished Service ProfessorAuthorship 322271826806071Chen J, Zhao M, Jiang X, Sizovs A, Wang MC, Provost CR, Huang J, Wang JThe AnalystGenetically anchored fluorescent probes for subcellular specific imaging of hydrogen sulfide. Analyst. 2016 Feb 21; 141(4):1209-1213.Analyst2016-02-21T00:00:002016Genetically anchored fluorescent probes for subcellular specific imaging of hydrogen sulfide.27021842Liu X, Lu YF, Guan X, Zhao M, Wang J, Li FBiochemical pharmacologyCharacterizing novel metabolic pathways of melatonin receptor agonist agomelatine using metabolomic approaches. Biochem Pharmacol. 2016 06 01; 109:70-82.Biochem Pharmacol2016-03-25T00:00:002016Characterizing novel metabolic pathways of melatonin receptor agonist agomelatine using metabolomic approaches.27084884Song X, Chen J, Zhao M, Zhang C, Yu Y, Lonard DM, Chow DC, Palzkill T, Xu J, O'Malley BW, Wang JProceedings of the National Academy of Sciences of the United States of AmericaDevelopment of potent small-molecule inhibitors to drug the undruggable steroid receptor coactivator-3. Proc Natl Acad Sci U S A. 2016 May 03; 113(18):4970-5.Proc Natl Acad Sci U S A2016-04-15T00:00:002016Development of potent small-molecule inhibitors to drug the undruggable steroid receptor coactivator-3.17718577Wang J, Kubicki J, Platz MSOrganic lettersAn ultrafast study of phenyl azide: the direct observation of phenylnitrenium ion. Org Lett. 2007 Sep 27; 9(20):3973-6.Org Lett2007-08-25T00:00:002007An ultrafast study of phenyl azide: the direct observation of phenylnitrenium ion.Authorship 122584523848502Chen J, Zhao M, Feng F, Sizovs A, Wang JJournal of the American Chemical SocietyTunable thioesters as "reduction" responsive functionality for traceless reversible protein PEGylation. J Am Chem Soc. 2013 Jul 31; 135(30):10938-41.J Am Chem Soc2013-07-16T00:00:002013Tunable thioesters as "reduction" responsive functionality for traceless reversible protein PEGylation.18656918Wang J, Burdzinski G, Kubicki J, Platz MSJournal of the American Chemical SocietyUltrafast UV-vis and IR studies of p-biphenylyl acetyl and carbomethoxy carbenes. J Am Chem Soc. 2008 Aug 20; 130(33):11195-209.J Am Chem Soc2008-07-26T00:00:002008Ultrafast UV-vis and IR studies of p-biphenylyl acetyl and carbomethoxy carbenes.21117638Burdzinski G, Zhang Y, Wang J, Platz MSThe journal of physical chemistry. AConcerted Wolff rearrangement in two simple acyclic diazocarbonyl compounds. J Phys Chem A. 2010 Dec 23; 114(50):13065-8.J Phys Chem A2010-11-30T00:00:002010Concerted Wolff rearrangement in two simple acyclic diazocarbonyl compounds.21695781Wang J, Byrne JD, Napier ME, DeSimone JMSmall (Weinheim an der Bergstrasse, Germany)More effective nanomedicines through particle design. Small. 2011 Jul 18; 7(14):1919-31.Small2011-06-22T00:00:002011More effective nanomedicines through particle design.17031952Burdzinski G, Hackett JC, Wang J, Gustafson TL, Hadad CM, Platz MSJournal of the American Chemical SocietyEarly events in the photochemistry of aryl azides from femtosecond UV/Vis spectroscopy and quantum chemical calculations. J Am Chem Soc. 2006 Oct 18; 128(41):13402-11.J Am Chem Soc2006-10-18T00:00:002006Early events in the photochemistry of aryl azides from femtosecond UV/Vis spectroscopy and quantum chemical calculations.17567009Wang J, Burdzinski G, Zhu Z, Platz MS, Carra C, Bally TJournal of the American Chemical SocietyUltrafast spectroscopic and matrix isolation studies of p-biphenylyl, o-biphenylyl, and 1-naphthylnitrenium cations. J Am Chem Soc. 2007 Jul 04; 129(26):8380-8.J Am Chem Soc2007-06-13T00:00:002007Ultrafast spectroscopic and matrix isolation studies of p-biphenylyl, o-biphenylyl, and 1-naphthylnitrenium cations.17935331Wang J, Kubicki J, Hilinski EF, Mecklenburg SL, Gustafson TL, Platz MSJournal of the American Chemical SocietyUltrafast study of 9-diazofluorene: direct observation of the first two singlet states of fluorenylidene. J Am Chem Soc. 2007 Nov 07; 129(44):13683-90.J Am Chem Soc2007-10-13T00:00:002007Ultrafast study of 9-diazofluorene: direct observation of the first two singlet states of fluorenylidene.17985908Wang YT, Wang J, Platz MS, Novak MJournal of the American Chemical SocietyDirect detection of a transient oxenium ion in water generated by laser flash photolysis. J Am Chem Soc. 2007 Nov 28; 129(47):14566-7.J Am Chem Soc2007-11-07T00:00:002007Direct detection of a transient oxenium ion in water generated by laser flash photolysis.17824713Wang J, Kubicki J, Burdzinski G, Hackett JC, Gustafson TL, Hadad CM, Platz MSThe Journal of organic chemistryEarly events in the photochemistry of 2-naphthyl azide from femtosecond UV/Vis spectroscopy and quantum chemical calculations: direct observation of a very short-lived singlet nitrene. J Org Chem. 2007 Sep 28; 72(20):7581-6.J Org Chem2007-09-08T00:00:002007Early events in the photochemistry of 2-naphthyl azide from femtosecond UV/Vis spectroscopy and quantum chemical calculations: direct observation of a very short-lived singlet nitrene.18465011Wang J, Zhang Y, Kubicki J, Platz MSPhotochemical & photobiological sciences : Official journal of the European Photochemistry Association and the European Society for PhotobiologyUltrafast studies of some diarylcarbenes. Photochem Photobiol Sci. 2008 May; 7(5):552-7.Photochem Photobiol Sci2008-03-20T00:00:002008Ultrafast studies of some diarylcarbenes.18001041Wang J, Burdzinski G, Platz MSOrganic lettersSolvent effects on intermolecular proton transfer: the rates of nitrene protonation and their correlation with Swain acity. Org Lett. 2007 Dec 06; 9(25):5211-4.Org Lett2007-11-15T00:00:002007Solvent effects on intermolecular proton transfer: the rates of nitrene protonation and their correlation with Swain acity.18215044Wang J, Kubicki J, Gustafson TL, Platz MSJournal of the American Chemical SocietyThe dynamics of carbene solvation: an ultrafast study of p-biphenylyltrifluoromethylcarbene. J Am Chem Soc. 2008 Feb 20; 130(7):2304-13.J Am Chem Soc2008-01-24T00:00:002008The dynamics of carbene solvation: an ultrafast study of p-biphenylyltrifluoromethylcarbene.18311982Burdzinski GT, Wang J, Gustafson TL, Platz MSJournal of the American Chemical SocietyStudy of concerted and sequential photochemical Wolff Rearrangement by femtosecond UV-vis and IR spectroscopy. J Am Chem Soc. 2008 Mar 26; 130(12):3746-7.J Am Chem Soc2008-03-01T00:00:002008Study of concerted and sequential photochemical Wolff Rearrangement by femtosecond UV-vis and IR spectroscopy.18366167Wang J, Burdzinski G, Kubicki J, Gustafson TL, Platz MSJournal of the American Chemical SocietyUltrafast carbene-carbene isomerization. J Am Chem Soc. 2008 Apr 23; 130(16):5418-9.J Am Chem Soc2008-03-26T00:00:002008Ultrafast carbene-carbene isomerization.18433130Wang J, Kubicki J, Peng H, Platz MSJournal of the American Chemical SocietyInfluence of solvent on carbene intersystem crossing rates. J Am Chem Soc. 2008 May 21; 130(20):6604-9.J Am Chem Soc2008-04-24T00:00:002008Influence of solvent on carbene intersystem crossing rates.18816025Burdzinski G, R?hault J, Wang J, Platz MSThe journal of physical chemistry. AA study of the photochemistry of Diazo Meldrum's acid by ultrafast time-resolved spectroscopies. J Phys Chem A. 2008 Oct 16; 112(41):10108-12.J Phys Chem A2008-09-25T00:00:002008A study of the photochemistry of Diazo Meldrum's acid by ultrafast time-resolved spectroscopies.18844332Zhang Y, Kubicki J, Wang J, Platz MSThe journal of physical chemistry. A2-Naphthyl(carbomethoxy)carbene revisited: combination of ultrafast UV-vis and infrared spectroscopic study. J Phys Chem A. 2008 Nov 06; 112(44):11093-8.J Phys Chem A2008-10-10T00:00:0020082-Naphthyl(carbomethoxy)carbene revisited: combination of ultrafast UV-vis and infrared spectroscopic study.18975865Wang YT, Jin KJ, Leopold SH, Wang J, Peng HL, Platz MS, Xue J, Phillips DL, Glover SA, Novak MJournal of the American Chemical SocietyCharacterization of reactive intermediates generated during photolysis of 4-acetoxy-4-aryl-2,5-cyclohexadienones: oxenium ions and aryloxy radicals. J Am Chem Soc. 2008 Nov 26; 130(47):16021-30.J Am Chem Soc2008-11-26T00:00:002008Characterization of reactive intermediates generated during photolysis of 4-acetoxy-4-aryl-2,5-cyclohexadienones: oxenium ions and aryloxy radicals.27894063Pham K, Dong J, Jiang X, Qu Y, Yu H, Yang Y, Olea W, Marini JC, Chan L, Wang J, Wehrens XH, Cui X, Li Y, Hadsell DL, Cheng NAmerican journal of physiology. Endocrinology and metabolismLoss of glutaredoxin 3 impedes mammary lobuloalveolar development during pregnancy and lactation. Am J Physiol Endocrinol Metab. 2017 03 01; 312(3):E136-E149.Am J Physiol Endocrinol Metab2016-11-15T00:00:002016Loss of glutaredoxin 3 impedes mammary lobuloalveolar development during pregnancy and lactation.20698697Wang J, Tian S, Petros RA, Napier ME, Desimone JMJournal of the American Chemical SocietyThe complex role of multivalency in nanoparticles targeting the transferrin receptor for cancer therapies. J Am Chem Soc. 2010 Aug 18; 132(32):11306-13.J Am Chem Soc2010-08-18T00:00:002010The complex role of multivalency in nanoparticles targeting the transferrin receptor for cancer therapies.MINGZHAOMING ZHAO12713ZHAO, MINGAssistant Professor - SHP21648388Xue J, Vyas S, Du Y, Luk HL, Chuang YP, But TY, Toy PH, Wang J, Winter AH, Phillips DL, Hadad CM, Platz MSThe journal of physical chemistry. ATime-resolved resonance Raman and computational investigation of the influence of 4-acetamido and 4-N-methylacetamido substituents on the chemistry of phenylnitrene. J Phys Chem A. 2011 Jul 07; 115(26):7521-30.J Phys Chem A2011-06-07T00:00:002011Time-resolved resonance Raman and computational investigation of the influence of 4-acetamido and 4-N-methylacetamido substituents on the chemistry of phenylnitrene.22475061Dunn SS, Tian S, Blake S, Wang J, Galloway AL, Murphy A, Pohlhaus PD, Rolland JP, Napier ME, DeSimone JMJournal of the American Chemical SocietyReductively responsive siRNA-conjugated hydrogel nanoparticles for gene silencing. J Am Chem Soc. 2012 May 02; 134(17):7423-30.J Am Chem Soc2012-04-19T00:00:002012Reductively responsive siRNA-conjugated hydrogel nanoparticles for gene silencing.21548657Kubicki J, Zhang Y, Vyas S, Burdzinski G, Luk HL, Wang J, Xue J, Peng HL, Pritchina EA, Sliwa M, Buntinx G, Gritsan NP, Hadad CM, Platz MSJournal of the American Chemical SocietyPhotochemistry of 2-naphthoyl azide. An ultrafast time-resolved UV-vis and IR spectroscopic and computational study. J Am Chem Soc. 2011 Jun 29; 133(25):9751-61.J Am Chem Soc2011-06-02T00:00:002011Photochemistry of 2-naphthoyl azide. An ultrafast time-resolved UV-vis and IR spectroscopic and computational study.28611048Rohira AD, Yan F, Wang L, Wang J, Zhou S, Lu A, Yu Y, Xu J, Lonard DM, O'Malley BWCancer researchTargeting SRC Coactivators Blocks the Tumor-Initiating Capacity of Cancer Stem-like Cells. Cancer Res. 2017 08 15; 77(16):4293-4304.Cancer Res2017-06-13T00:00:002017Targeting SRC Coactivators Blocks the Tumor-Initiating Capacity of Cancer Stem-like Cells.28622510Han B, Sivaramakrishnan P, Lin CJ, Neve IAA, He J, Tay LWR, Sowa JN, Sizovs A, Du G, Wang J, Herman C, Wang MCCellMicrobial Genetic Composition Tunes Host Longevity. Cell. 2017 Jun 15; 169(7):1249-1262.e13.Cell2017-06-15T00:00:002017Microbial Genetic Composition Tunes Host Longevity.11992504Tang F, Wang J, Liu D, Yuan G, Liu Y, Jin Zhu C, Fen Zhao YRapid communications in mass spectrometry : RCMElectrospray ionization tandem mass spectrometric characteristics and fragmentation mechanisms of distamycin analogues. Rapid Commun Mass Spectrom. 2002; 16(11):1035-9.Rapid Commun Mass Spectrom2002-01-01T00:00:002002Electrospray ionization tandem mass spectrometric characteristics and fragmentation mechanisms of distamycin analogues.28703127Jiang X, Chen J, Bajic A, Zhang C, Song X, Carroll SL, Cai ZL, Tang M, Xue M, Cheng N, Schaaf CP, Li F, MacKenzie KR, Ferreon ACM, Xia F, Wang MC, Maletic-Savatic M, Wang JNature communicationsQuantitative real-time imaging of glutathione. Nat Commun. 2017 07 13; 8:16087.Nat Commun2017-07-13T00:00:002017Quantitative real-time imaging of glutathione.12945586Tang FL, Yuan G, Wang JPhotochemistry and photobiologySynthesis and photoinduced DNA cleaving activity of hairpin polyamide-chlorobenzenesulfonyl conjugates. Photochem Photobiol. 2003 Aug; 78(2):175-9.Photochem Photobiol2003-08-01T00:00:002003Synthesis and photoinduced DNA cleaving activity of hairpin polyamide-chlorobenzenesulfonyl conjugates.28809477Chen J, Jiang X, Zhang C, MacKenzie KR, Stossi F, Palzkill T, Wang MC, Wang JACS sensorsReversible Reaction-Based Fluorescent Probe for Real-Time Imaging of Glutathione Dynamics in Mitochondria. ACS Sens. 2017 Sep 22; 2(9):1257-1261.ACS Sens2017-08-18T00:00:002017Reversible Reaction-Based Fluorescent Probe for Real-Time Imaging of Glutathione Dynamics in Mitochondria.16872208Wang J, Burdzinski G, Gustafson TL, Platz MSThe Journal of organic chemistryUltrafast study of p-biphenylyldiazomethane and p-biphenylylcarbene. J Org Chem. 2006 Aug 04; 71(16):6221-8.J Org Chem2006-08-04T00:00:002006Ultrafast study of p-biphenylyldiazomethane and p-biphenylylcarbene.17177362Wang J, Burdzinski G, Kubicki J, Platz MS, Moss RA, Fu X, Piotrowiak P, Myahkostupov MJournal of the American Chemical SocietyUltrafast spectroscopic study of the photochemistry and photophysics of arylhalodiazirines: direct observation of carbene and zwitterion formation. J Am Chem Soc. 2006 Dec 27; 128(51):16446-7.J Am Chem Soc2006-12-27T00:00:002006Ultrafast spectroscopic study of the photochemistry and photophysics of arylhalodiazirines: direct observation of carbene and zwitterion formation.17290992Wang J, Burdzinski G, Gustafson TL, Platz MSJournal of the American Chemical SocietyUltrafast study of p-biphenylyldiazoethane. The chemistry of the diazo excited state and the relaxed carbene. J Am Chem Soc. 2007 Mar 07; 129(9):2597-606.J Am Chem Soc2007-02-10T00:00:002007Ultrafast study of p-biphenylyldiazoethane. The chemistry of the diazo excited state and the relaxed carbene.18225870Xue J, Du Y, Chuang YP, Phillips DL, Wang J, Luk C, Hadad CM, Platz MSThe journal of physical chemistry. ATime-resolved resonance Raman observation of the dimerization of didehydroazepines in solution. J Phys Chem A. 2008 Feb 21; 112(7):1502-10.J Phys Chem A2008-01-29T00:00:002008Time-resolved resonance Raman observation of the dimerization of didehydroazepines in solution.19317497Kubicki J, Zhang Y, Wang J, Luk HL, Peng HL, Vyas S, Platz MSJournal of the American Chemical SocietyDirect observation of acyl azide excited states and their decay processes by ultrafast time resolved infrared spectroscopy. J Am Chem Soc. 2009 Apr 01; 131(12):4212-3.J Am Chem Soc2009-04-01T00:00:002009Direct observation of acyl azide excited states and their decay processes by ultrafast time resolved infrared spectroscopy.22568387Xu J, Wang J, Luft JC, Tian S, Owens G, Pandya AA, Berglund P, Pohlhaus P, Maynor BW, Smith J, Hubby B, Napier ME, DeSimone JMJournal of the American Chemical SocietyRendering protein-based particles transiently insoluble for therapeutic applications. J Am Chem Soc. 2012 May 30; 134(21):8774-7.J Am Chem Soc2012-05-17T00:00:002012Rendering protein-based particles transiently insoluble for therapeutic applications.29320869Jiang X, Wang L, Carroll SL, Chen J, Wang MC, Wang JAntioxidants & redox signalingChallenges and Opportunities for Small-Molecule Fluorescent Probes in Redox Biology Applications. Antioxid Redox Signal. 2018 08 20; 29(6):518-540.Antioxid Redox Signal2018-02-16T00:00:002018Challenges and Opportunities for Small-Molecule Fluorescent Probes in Redox Biology Applications.29686249Jiang X, Chen J, Wang JNature communicationsReply to 'Pitfalls in the quantitative imaging of glutathione in living cells'. Nat Commun. 2018 04 23; 9(1):1589.Nat Commun2018-04-23T00:00:002018Reply to 'Pitfalls in the quantitative imaging of glutathione in living cells'.true1Assistant ProfessorAssistant ProfessorD057054Procedures1161840.8421Molecular ImagingAuthorship 8903789Authorship 8903793Authorship 8903806Authorship 8903811Authorship 8903828Authorship 89038318Authorship 89038410Authorship 8903854Authorship 89038610Authorship 89038711Authorship 890388529748621Gates LA, Gu G, Chen Y, Rohira AD, Lei JT, Hamilton RA, Yu Y, Lonard DM, Wang J, Wang SP, Edwards DG, Lavere PF, Shao J, Yi P, Jain A, Jung SY, Malovannaya A, Li S, Shao J, Roeder RG, Ellis MJ, Qin J, Fuqua SAW, O'Malley BW, Foulds CEOncogeneProteomic profiling identifies key coactivators utilized by mutant ERa proteins as potential new therapeutic targets. Oncogene. 2018 08; 37(33):4581-4598.Oncogene2018-05-11T00:00:002018Proteomic profiling identifies key coactivators utilized by mutant ERa proteins as potential new therapeutic targets.29183814Rothmiller S, Schr?der S, Strobelt R, Wolf M, Wang J, Jiang X, Worek F, Steinritz D, Thiermann H, Schmidt AToxicology lettersSulfur mustard resistant keratinocytes obtained elevated glutathione levels and other changes in the antioxidative defense mechanism. Toxicol Lett. 2018 Sep 01; 293:51-61.Toxicol Lett2017-11-26T00:00:002017Sulfur mustard resistant keratinocytes obtained elevated glutathione levels and other changes in the antioxidative defense mechanism.D056921Chemicals & Drugs903760.80405Nuclear Receptor Coactivator 3D010084Phenomena3227420.840801Oxidation-ReductionD005456Chemicals & Drugs2844570.813243Fluorescent DyesAuthorship 89152313Authorship 8915241830358421Jiang X, Zhang C, Chen J, Choi S, Zhou Y, Zhao M, Song X, Chen X, Maletic-Savatic M, Palzkill T, Moore D, Wang MC, Wang JAntioxidants & redox signalingQuantitative Real-Time Imaging of Glutathione with Subcellular Resolution. Antioxid Redox Signal. 2019 06 01; 30(16):1900-1910.Antioxid Redox Signal2018-12-20T00:00:002018Quantitative Real-Time Imaging of Glutathione with Subcellular Resolution.30349055Li Y, Liu Y, Xu H, Jiang G, Van der Jeught K, Fang Y, Zhou Z, Zhang L, Frieden M, Wang L, Luo Z, Radovich M, Schneider BP, Deng Y, Liu Y, Huang K, He B, Wang J, He X, Zhang X, Ji G, Lu XNature communicationsHeterozygous deletion of chromosome 17p renders prostate cancer vulnerable to inhibition of RNA polymerase II. Nat Commun. 2018 10 22; 9(1):4394.Nat Commun2018-10-22T00:00:002018Heterozygous deletion of chromosome 17p renders prostate cancer vulnerable to inhibition of RNA polymerase II.D005978Chemicals & Drugs1833680.822043Glutathione30423406Song X, Chen H, Zhang C, Yu Y, Chen Z, Liang H, Van Buren G, McElhany AL, Fisher WE, Lonard DM, O'Malley BW, Wang JCancer lettersSRC-3 inhibition blocks tumor growth of pancreatic ductal adenocarcinoma. Cancer Lett. 2019 02 01; 442:310-319.Cancer Lett2018-11-10T00:00:002018SRC-3 inhibition blocks tumor growth of pancreatic ductal adenocarcinoma.2022-02-28NIHWANG, JIN2017-03-15Drugging the Undruggable Coactivators using Small Molecule InhibitorsR01CA2077012021-07-31NIHWANG, JIN2015-09-22REAL-TIME QUANTITATIVE IMAGING OF INTRACELLULAR BIOTHIOL DYNAMICSR01GM1156222019-11-30NIHWANG, JIN2017-06-13Engineering Antibody Drug Conjugates To Target P53-Defective Triple Negative Breast CancerR21CA2135352023-05-31NIH/NIAZHENG, HUI2018-09-15Targeting a lipid-mediated pro-longevity pathway as Alzheimer's therapyR01AG062257Principal InvestigatorCo-Principal InvestigatorPrincipal InvestigatorPrincipal InvestigatorPathologyDepartment of PediatricsDepartment of Molecular & Cellular BiologyDepartment of Pathology & ImmunologyMolecular & Cellular BiologyPathologyPediatrics-NutritionBaylor College of Medicine3.980330.00742219326research areas1.029440.03425344coauthor of39.28536.1201260similar to1167selected publicationsZHENGZHOUZHENG ZHOU0.000000000000000.000000000000002128ZHOU, ZHENGProfessorNINGHUICHENGNINGHUI CHENG0.000000000000000.00000000000000258CHENG, NINGHUIAssistant ProfessorMATASSIM ATASSI0.000000000000000.000000000000003024ATASSI, MProfessor EmeritusSUKYEONGLEESUKYEONG LEE0.000000000000000.00000000000000262LEE, SUKYEONGAssociate ProfessorTHEODOREWENSELTHEODORE WENSEL0.000000000000000.000000000000003220WENSEL, THEODOREProfessorSHELLEYSAZERSHELLEY SAZER0.000000000000000.000000000000003362SAZER, SHELLEYProfessor EmeritusBERTO'MALLEYBERT O'MALLEY0.000000000000000.000000000000002464O'MALLEY, BERTDistinguished Service ProfessorDAVIDLONARDDAVID LONARD0.000000000000000.000000000000003522LONARD, DAVIDProfessorAuthorship 106369331033205Donelson J, Wang Q, Monroe TO, Jiang X, Zhou J, Yu H, Mo Q, Sun Q, Marini JC, Wang X, Nakata PA, Hirschi KD, Wang J, Rodney GG, Wehrens XHT, Cheng NPhysiological reportsCardiac-specific ablation of glutaredoxin 3 leads to cardiac hypertrophy and heart failure. Physiol Rep. 2019 04; 7(8):e14071.Physiol Rep2019-04-01T00:00:002019Cardiac-specific ablation of glutaredoxin 3 leads to cardiac hypertrophy and heart failure.Authorship 1066022true1Distinguished Service ProfessorDistinguished Service Professor2025-06-30NIHWANG, JIN ;WANG, MICHAEL ;WOYACH, JENNIFER A.2020-07-01Reversible Covalent BTK Degraders as the Next Generation Targeted Therapy to Treat B-cell MalignanciesR01CA250503Principal Investigator32712217MacKenzie KR, Zhao M, Barzi M, Wang J, Bissig KD, Maletic-Savatic M, Jung SY, Li FEuropean journal of pharmaceutical sciences : official journal of the European Federation for Pharmaceutical SciencesMetabolic profiling of norepinephrine reuptake inhibitor atomoxetine. 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Ann Pancreat Cancer. 2019 Oct; 2.Ann Pancreat Cancer2019-10-23T00:00:002019Evolving trends in pancreatic cancer therapeutic development.Twitter Tweets Harvard TweetsAuthorship 10073172Authorship 100731815Authorship 10073199Authorship 100732018Authorship 10073214Authorship 100732223Authorship 10073238Authorship 100732413Authorship 10073251212/2007The Ohio State UniversityColumbus, OHThe Ohio State University, Organic ChemistryPh.D.Organic Chemistry05/2011University of North CarolinaChapel Hill, NCUniversity of North Carolina, Drug DeliveryPostdocDrug Delivery32990678Fang Y, Wang L, Wan C, Sun Y, Van der Jeught K, Zhou Z, Dong T, So KM, Yu T, Li Y, Eyvani H, Colter AB, Dong E, Cao S, Wang J, Schneider BP, Sandusky GE, Liu Y, Zhang C, Lu X, Zhang XThe Journal of clinical investigationMAL2 drives immune evasion in breast cancer by suppressing tumor antigen presentation. J Clin Invest. 2021 01 04; 131(1).J Clin Invest2021-01-04T00:00:002021MAL2 drives immune evasion in breast cancer by suppressing tumor antigen presentation.32284594Mendiola AS, Ryu JK, Bardehle S, Meyer-Franke A, Ang KK, Wilson C, Baeten KM, Hanspers K, Merlini M, Thomas S, Petersen MA, Williams A, Thomas R, Rafalski VA, Meza-Acevedo R, Tognatta R, Yan Z, Pfaff SJ, Machado MR, Bedard C, Rios Coronado PE, Jiang X, Wang J, Pleiss MA, Green AJ, Zamvil SS, Pico AR, Bruneau BG, Arkin MR, Akassoglou KNature immunologyTranscriptional profiling and therapeutic targeting of oxidative stress in neuroinflammation. 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Cell Rep. 2019 02 05; 26(6):1544-1556.e8.Cell Rep2019-02-05T00:00:002019A Genome-wide Haploid Genetic Screen Identifies Regulators of Glutathione Abundance and Ferroptosis Sensitivity.Authorship 1300369Authorship 11352612023-03-31NIHZHENG, HUI2018-09-15Targeting a lipid-mediated pro-longevity pathway as Alzheimer's therapyRF1AG0622572025-05-31NIHWANG, JIN ;ZHENG, HUI2020-09-15Developing Novel Soluble Epoxide Hydrolase Inhibitors for the Treatment of Alzheimer's DiseaseU01AG068031Co-Principal InvestigatorPrincipal Investigator33589584Liu J, Xie Y, Guo J, Li X, Wang J, Jiang H, Peng Z, Wang J, Wang S, Li Q, Ye L, Zhong Y, Zhang Q, Liu X, Lonard DM, Wang J, O'Malley BW, Liu ZNature communicationsTargeting NSD2-mediated SRC-3 liquid-liquid phase separation sensitizes bortezomib treatment in multiple myeloma. Nat Commun. 2021 02 15; 12(1):1022.Nat Commun2021-02-15T00:00:002021Targeting NSD2-mediated SRC-3 liquid-liquid phase separation sensitizes bortezomib treatment in multiple myeloma.33806862Foster J, Cheng N, Paris V, Wang L, Wang J, Wang X, Nakata PAInternational journal of molecular sciencesAn Arabidopsis Oxalyl-CoA Decarboxylase, AtOXC, Is Important for Oxalate Catabolism in Plants. Int J Mol Sci. 2021 Mar 23; 22(6).Int J Mol Sci2021-03-23T00:00:002021An Arabidopsis Oxalyl-CoA Decarboxylase, AtOXC, Is Important for Oxalate Catabolism in Plants.24344996Sizovs A, Song X, Waxham MN, Jia Y, Feng F, Chen J, Wicker AC, Xu J, Yu Y, Wang JJournal of the American Chemical SocietyPrecisely tunable engineering of sub-30 nm monodisperse oligonucleotide nanoparticles. J Am Chem Soc. 2014 Jan 08; 136(1):234-40.J Am Chem Soc2013-12-17T00:00:002013Precisely tunable engineering of sub-30 nm monodisperse oligonucleotide nanoparticles.Authorship 10231925Authorship 10231935Authorship 10231944Authorship 1023195433377064Jiang X, Chen J, Wang MC, Wang JSTAR protocolsGlutathione Quantification in Live Cells with Real-Time Imaging and Flow Cytometry. STAR Protoc. 2020 12 18; 1(3):100170.STAR Protoc2020-11-14T00:00:002020Glutathione Quantification in Live Cells with Real-Time Imaging and Flow Cytometry.33755462Rhoades D, Rheingold AL, O'Malley BW, Wang JJournal of the American Chemical SocietyExpedient Total Syntheses of Pladienolide-Derived Spliceosome Modulators. J Am Chem Soc. 2021 04 07; 143(13):4915-4920.J Am Chem Soc2021-03-23T00:00:002021Expedient Total Syntheses of Pladienolide-Derived Spliceosome Modulators.true1Associate ProfessorAssociate ProfessorAuthorship 1176533true1Professor EmeritusProfessor Emeritustrue1ProfessorProfessor2ProfessorProfessortrue1Professor EmeritusProfessor Emeritustrue1Associate ProfessorAssociate Professortrue1ProfessorProfessorDepartment of Biochemistry and Molecular PharmacologyBiochemistry & Mol Pharmacologytrue1ProfessorProfessorAuthorship 202872true1ProfessorProfessortrue1ProfessorProfessortrue1ProfessorProfessortrue1Assistant Professor - SHPAssistant Professor - SHPtrue1ProfessorProfessortrue1ProfessorProfessorAuthorship 283544FENGLIFENG LI7099LI, FENGAssociate ProfessorAuthorship 312176Authorship 314001Authorship 139772624390736Wang Y, Lonard DM, Yu Y, Chow DC, Palzkill TG, Wang J, Qi R, Matzuk AJ, Song X, Madoux F, Hodder P, Chase P, Griffin PR, Zhou S, Liao L, Xu J, O'Malley BWCancer researchBufalin is a potent small-molecule inhibitor of the steroid receptor coactivators SRC-3 and SRC-1. 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