WEEI-CHINLINWEEI-CHIN LIN0.000000000000000.000000000000001687LIN, WEEI-CHINProfessorprns:awardConferredByaward conferred byprns:coAuthorOfcoauthor ofprns:endDateend dateFaculty Rankprns:fullNamefull nameprns:grantAwardedBygrant awarded byprns:hasAuthorListauthor listprns:hasFacultyRankhas faculty rankprns:hasNetworkhas networkprns:hasPublicationVenuepublished inprns:informationResourceReferenceinformation resource referenceprns:isPrimaryPositionis primary positionprns:latitudelatitudeprns:longitudelongitudeprns:mainImagephotoprns:maxWeightmaximum weightprns:medlineTAjournal title abbreviationprns:meshDescriptorUIMeSH DescriptorUIprns:meshSemanticGroupNameMeSH semantic group nameprns:minWeightminimum weightprns:numberOfAuthorsnumber of authorsprns:numberOfConnectionsnumber of connectionsprns:numberOfPublicationsnumber of publicationsprns:personIdPerson IDprns:personInPrimaryPositionperson in primary positionprns:physicalNeighborOfphysical neighborprns:positionInDepartmentposition in departmentprns:positionInDivisionposition in divisionprns:predicateNodepredicate nodeprns:principalInvestigatorNameprincipal investigator nameprns:publicationDatepublication dateprns:similarTosimilar toprns:sortOrdersort orderprns:startDatestart dateprns:uniquenessWeightuniqueness weightprns:yearyearAcademic ArticleArticleDocumentbibo:pmidPubMed IdentifierAddressvivo:address1address line 1vivo:addressCitycityvivo:addressPostalCodepostal codevivo:addressStatestate or provinceAgreementvivo:authorInAuthorshipselected publicationsvivo:authorRankauthor rank in publicationAuthorshipvivo:awardOrHonorawards and honorsAward or Honor ReceiptDepartmentDivisionGrantvivo:hasResearchArearesearch areasvivo:hasResearcherRoleresearch activitiesvivo:hrJobTitleHR job titleInformation Resourcevivo:linkedAuthorlinked authorvivo:linkedInformationResourcelinked information resourcevivo:mailingAddressmailing addressvivo:personInPositionpositionsPositionvivo:positionInOrganizationposition in organizationvivo:preferredTitlepreferred titleResearcher Rolevivo:researcherRoleOfresearcher role ofRolevivo:roleContributesTocontributes tovivo:sponsorAwardIdsponsor award idrdf:predicatepredicaterdf:typetyperdfs:labellabelConceptAgentfoaf:firstNamefirst namefoaf:lastNamelast nameOrganizationPersonAuthorship 823024Authorship 882513Authorship 939883Authorship 278792Authorship 353887Authorship 398205Experimental Radiation OncologyGeneticsMolecular & Cellular OncologySystems BiologyMD AndersonMIEN-CHIEHUNGMIEN-CHIE HUNG8427HUNG, MIEN-CHIEProfessorGUILLERMINALOZANOGUILLERMINA LOZANO8500LOZANO, GUILLERMINAProfessorGORDON BMILLSGORDON B MILLS8620MILLS, GORDON BProfessorJUNJIECHENJUNJIE CHEN8830CHEN, JUNJIEProfessorAuthorship 500576Authorship 579856Authorship 280172326216882Ho SR, Lee YJ, Lin WCThe Journal of biological chemistryRegulation of RNF144A E3 Ubiquitin Ligase Activity by Self-association through Its Transmembrane Domain. J Biol Chem. 2015 Sep 18; 290(38):23026-38.J Biol Chem2015-07-27T00:00:002015Regulation of RNF144A E3 Ubiquitin Ligase Activity by Self-association through Its Transmembrane Domain.Authorship 281142526396186Mahanic CS, Budhavarapu V, Graves JD, Li G, Lin WCThe Journal of biological chemistryRegulation of E2 promoter binding factor 1 (E2F1) transcriptional activity through a deubiquitinating enzyme, UCH37. J Biol Chem. 2015 Oct 30; 290(44):26508-22.J Biol Chem2015-09-22T00:00:002015Regulation of E2 promoter binding factor 1 (E2F1) transcriptional activity through a deubiquitinating enzyme, UCH37.One Baylor PlazaHouston, 77030TX15075294Liu K, Luo Y, Lin FT, Lin WCGenes & developmentTopBP1 recruits Brg1/Brm to repress E2F1-induced apoptosis, a novel pRb-independent and E2F1-specific control for cell survival. Genes Dev. 2004 Mar 15; 18(6):673-86.Genes Dev2004-03-15T00:00:002004TopBP1 recruits Brg1/Brm to repress E2F1-induced apoptosis, a novel pRb-independent and E2F1-specific control for cell survival.15226443Luo Y, Lin FT, Lin WCMolecular and cellular biologyATM-mediated stabilization of hMutL DNA mismatch repair proteins augments p53 activation during DNA damage. Mol Cell Biol. 2004 Jul; 24(14):6430-44.Mol Cell Biol2004-07-01T00:00:002004ATM-mediated stabilization of hMutL DNA mismatch repair proteins augments p53 activation during DNA damage.74Professor48Distinguished Service Professor Emeritus54Instructor14Associate Professor3Adjunct Associate ProfessorJOHNTAINERJOHN TAINER11926TAINER, JOHNProfessor20454448Wang B, Ling S, Lin WCPloS one14-3-3Tau regulates Beclin 1 and is required for autophagy. PLoS One. 2010 Apr 29; 5(4):e10409.PLoS One2010-04-29T00:00:00201014-3-3Tau regulates Beclin 1 and is required for autophagy.15494392Wang B, Liu K, Lin FT, Lin WCThe Journal of biological chemistryA role for 14-3-3 tau in E2F1 stabilization and DNA damage-induced apoptosis. J Biol Chem. 2004 Dec 24; 279(52):54140-52.J Biol Chem2004-10-19T00:00:002004A role for 14-3-3 tau in E2F1 stabilization and DNA damage-induced apoptosis.17006541Liu K, Paik JC, Wang B, Lin FT, Lin WCThe EMBO journalRegulation of TopBP1 oligomerization by Akt/PKB for cell survival. EMBO J. 2006 Oct 18; 25(20):4795-807.EMBO J2006-09-28T00:00:002006Regulation of TopBP1 oligomerization by Akt/PKB for cell survival.17965021Lin FT, Lai YJ, Makarova N, Tigyi G, Lin WCThe Journal of biological chemistryThe lysophosphatidic acid 2 receptor mediates down-regulation of Siva-1 to promote cell survival. J Biol Chem. 2007 Dec 28; 282(52):37759-69.J Biol Chem2007-10-26T00:00:002007The lysophosphatidic acid 2 receptor mediates down-regulation of Siva-1 to promote cell survival.17591779Lai YJ, Lin WC, Lin FTThe Journal of biological chemistryPTPL1/FAP-1 negatively regulates TRIP6 function in lysophosphatidic acid-induced cell migration. J Biol Chem. 2007 Aug 17; 282(33):24381-7.J Biol Chem2007-06-25T00:00:002007PTPL1/FAP-1 negatively regulates TRIP6 function in lysophosphatidic acid-induced cell migration.18660752Yang SZ, Lin FT, Lin WCEMBO reportsMCPH1/BRIT1 cooperates with E2F1 in the activation of checkpoint, DNA repair and apoptosis. EMBO Rep. 2008 Sep; 9(9):907-15.EMBO Rep2008-07-25T00:00:002008MCPH1/BRIT1 cooperates with E2F1 in the activation of checkpoint, DNA repair and apoptosis.19289498Liu K, Bellam N, Lin HY, Wang B, Stockard CR, Grizzle WE, Lin WCMolecular and cellular biologyRegulation of p53 by TopBP1: a potential mechanism for p53 inactivation in cancer. Mol Cell Biol. 2009 May; 29(10):2673-93.Mol Cell Biol2009-03-16T00:00:002009Regulation of p53 by TopBP1: a potential mechanism for p53 inactivation in cancer.Authorship 652071427134758Lin FT, Lin VY, Lin VT, Lin WCCell discoveryTRIP6 antagonizes the recruitment of A20 and CYLD to TRAF6 to promote the LPA2 receptor-mediated TRAF6 activation. Cell Discov. 2016; 2.Cell Discov2016-03-01T00:00:002016TRIP6 antagonizes the recruitment of A20 and CYLD to TRAF6 to promote the LPA2 receptor-mediated TRAF6 activation.20086099Wang B, Liu K, Lin HY, Bellam N, Ling S, Lin WCMolecular and cellular biology14-3-3Tau regulates ubiquitin-independent proteasomal degradation of p21, a novel mechanism of p21 downregulation in breast cancer. Mol Cell Biol. 2010 Mar; 30(6):1508-27.Mol Cell Biol2010-01-19T00:00:00201014-3-3Tau regulates ubiquitin-independent proteasomal degradation of p21, a novel mechanism of p21 downregulation in breast cancer.21930790Liu K, Ling S, Lin WCMolecular and cellular biologyTopBP1 mediates mutant p53 gain of function through NF-Y and p63/p73. Mol Cell Biol. 2011 Nov; 31(22):4464-81.Mol Cell Biol2011-09-19T00:00:002011TopBP1 mediates mutant p53 gain of function through NF-Y and p63/p73.23339869Lin VT, Lin VY, Lai YJ, Chen CS, Liu K, Lin WC, Lin FTMolecular and cellular biologyTRIP6 regulates p27 KIP1 to promote tumorigenesis. Mol Cell Biol. 2013 Apr; 33(7):1394-409.Mol Cell Biol2013-01-22T00:00:002013TRIP6 regulates p27 KIP1 to promote tumorigenesis.Authorship 869261528439015Liu K, Lin FT, Graves JD, Lee YJ, Lin WCProceedings of the National Academy of Sciences of the United States of AmericaMutant p53 perturbs DNA replication checkpoint control through TopBP1 and Treslin. Proc Natl Acad Sci U S A. 2017 05 09; 114(19):E3766-E3775.Proc Natl Acad Sci U S A2017-04-24T00:00:002017Mutant p53 perturbs DNA replication checkpoint control through TopBP1 and Treslin.12697828Liu K, Lin FT, Ruppert JM, Lin WCMolecular and cellular biologyRegulation of E2F1 by BRCT domain-containing protein TopBP1. Mol Cell Biol. 2003 May; 23(9):3287-304.Mol Cell Biol2003-05-01T00:00:002003Regulation of E2F1 by BRCT domain-containing protein TopBP1.14688263Xu J, Lai YJ, Lin WC, Lin FTThe Journal of biological chemistryTRIP6 enhances lysophosphatidic acid-induced cell migration by interacting with the lysophosphatidic acid 2 receptor. J Biol Chem. 2004 Mar 12; 279(11):10459-68.J Biol Chem2003-12-18T00:00:002003TRIP6 enhances lysophosphatidic acid-induced cell migration by interacting with the lysophosphatidic acid 2 receptor.Authorship 104585615988003Lai YJ, Chen CS, Lin WC, Lin FTMolecular and cellular biologyc-Src-mediated phosphorylation of TRIP6 regulates its function in lysophosphatidic acid-induced cell migration. Mol Cell Biol. 2005 Jul; 25(14):5859-68.Mol Cell Biol2005-07-01T00:00:002005c-Src-mediated phosphorylation of TRIP6 regulates its function in lysophosphatidic acid-induced cell migration.19739070Bhonde MR, Hanski ML, Stehr J, Jebautzke B, Peir?-Jord?n R, Fechner H, Yokoyama KK, Lin WC, Zeitz M, Hanski CInternational journal of cancerMismatch repair system decreases cell survival by stabilizing the tetraploid G1 arrest in response to SN-38. Int J Cancer. 2010 Jun 15; 126(12):2813-25.Int J Cancer2010-06-15T00:00:002010Mismatch repair system decreases cell survival by stabilizing the tetraploid G1 arrest in response to SN-38.20040599Paik JC, Wang B, Liu K, Lue JK, Lin WCThe Journal of biological chemistryRegulation of E2F1-induced apoptosis by the nucleolar protein RRP1B. J Biol Chem. 2010 Feb 26; 285(9):6348-63.J Biol Chem2009-12-29T00:00:002009Regulation of E2F1-induced apoptosis by the nucleolar protein RRP1B.21383020Ling S, Lin WCThe Journal of biological chemistryEDD inhibits ATM-mediated phosphorylation of p53. J Biol Chem. 2011 Apr 29; 286(17):14972-82.J Biol Chem2011-03-07T00:00:002011EDD inhibits ATM-mediated phosphorylation of p53.22580462Budhavarapu VN, White ED, Mahanic CS, Chen L, Lin FT, Lin WCCell cycle (Georgetown, Tex.)Regulation of E2F1 by APC/C Cdh1 via K11 linkage-specific ubiquitin chain formation. Cell Cycle. 2012 May 15; 11(10):2030-8.Cell Cycle2012-05-15T00:00:002012Regulation of E2F1 by APC/C Cdh1 via K11 linkage-specific ubiquitin chain formation.3ProfessorProfessortrue1Associate ProfessorAssociate Professortrue1InstructorInstructortrue1ProfessorProfessor2ProfessorProfessorD048948Chemicals & Drugs841430.91428414-3-3 ProteinsAuthorship 1026954D004268Chemicals & Drugs117148210.383682DNA-Binding ProteinsD002352Chemicals & Drugs76820300.532882Carrier ProteinsAuthorship 891290230171075Ho SR, Lin WCThe Journal of biological chemistryRNF144A sustains EGFR signaling to promote EGF-dependent cell proliferation. J Biol Chem. 2018 10 19; 293(42):16307-16323.J Biol Chem2018-08-31T00:00:002018RNF144A sustains EGFR signaling to promote EGF-dependent cell proliferation.D009687Chemicals & Drugs93033420.433335Nuclear ProteinsD050687Chemicals & Drugs932060.888548E2F1 Transcription Factor2020-07-31NIHLIN, WEEI-CHIN2014-08-05BCM Oncology Scholars Training ProgramT32CA1746472027-01-31NIHLIN, WEEI-CHIN2016-12-15Novel therapeutics for targeting checkpoint dysfunction in cancerR01CA2038242019-05-31NIHLIN, WEEI-CHIN2016-06-01New mechanisms of breast cancer metastasis and loss of estrogen receptor driven by 14-3-3R21CA1980412021-02-28NIHLIN, WEEI-CHIN2003-04-01The ATM/E2F1 Pathway in DNA Damage and Growth ControlR01CA1008572016-01-31NIHLIN, WEEI-CHIN2010-04-01Therapeutic Targeting of Oncogenic Stress in Cancer TreatmentR01CA138641Principal InvestigatorPrincipal InvestigatorPrincipal InvestigatorPrincipal InvestigatorPrincipal InvestigatorDepartment of MedicineDepartment of Molecular & Cellular BiologyDuncan Cancer CenterMedicine-Hematology & OncologyMolecular & Cellular BiologyCancer CenterBaylor College of MedicineYONGCHENGSONGYONGCHENG SONG0.000000000000000.000000000000001486SONG, YONGCHENGProfessor4.036730.00449408307research areas4.102280.1853759coauthor of88.864717.884960similar to1153selected publicationsKANGLIUKANG LIU0.000000000000000.000000000000001707LIU, KANGInstructorJULIENANGIAJULIE NANGIA0.000000000000000.000000000000001756NANGIA, JULIEAssociate ProfessorKEITHCHANKEITH CHAN29.70508570000000-95.401808700000001603CHAN, KEITHAdjunct Associate ProfessorSARVARIYELLAPRAGADASARVARI YELLAPRAGADA0.000000000000000.00000000000000998YELLAPRAGADA, SARVARIProfessorEDWARDLYNCHEDWARD LYNCH0.000000000000000.000000000000004137LYNCH, EDWARDDistinguished Service Professor EmeritusFANG-TSYRLINFANG-TSYR LIN0.000000000000000.000000000000003942LIN, FANG-TSYRAssociate ProfessorAuthorship 962122631801577Lee YJ, Ho SR, Graves JD, Xiao Y, Huang S, Lin WCBreast cancer research : BCRCGRRF1, a growth suppressor, regulates EGFR ubiquitination in breast cancer. Breast Cancer Res. 2019 12 04; 21(1):134.Breast Cancer Res2019-12-04T00:00:002019CGRRF1, a growth suppressor, regulates EGFR ubiquitination in breast cancer.Authorship 976061531964753Liu K, Graves JD, Lee YJ, Lin FT, Lin WCMolecular and cellular biologyCell Cycle-Dependent Switch of TopBP1 Functions by Cdk2 and Akt. Mol Cell Biol. 2020 03 30; 40(8).Mol Cell Biol2020-03-30T00:00:002020Cell Cycle-Dependent Switch of TopBP1 Functions by Cdk2 and Akt.SHIUH-RONGHOSHIUH-RONG HO0.000000000000000.000000000000006118HO, SHIUH-RONGFaculty ClinicianZEYIZHENGZEYI ZHENG0.000000000000000.000000000000005923ZHENG, ZEYIInstructorAuthorship 1134083Baylor College of Medicine2010Dan Duncan Professorship of Oncology, Baylor College of MedicineUniversity of Alabama at Birmingham20112006Leukemia & Lymphoma Society ScholarUniversity of Alabama at Birmingham20052002General Motors Cancer Research ScholarUniversity of Alabama at Birmingham20042001Breast SPORE Career Development Award, UABUniversity of Alabama at Birmingham 20042001Howard Hughes Medical Institute Junior Faculty Development AwardDuke University20011998Physician Scientist Award, Damon Runyon-Walter Winchell Foundation Johns Hopkins University School of Medicine1993the Martin and Carol Macht Research Prize, Johns Hopkins University School of Medicine51Faculty ClinicianAuthorship 991924632541040Graves JD, Lee YJ, Liu K, Li G, Lin FT, Lin WCProceedings of the National Academy of Sciences of the United States of AmericaE2F1 sumoylation as a protective cellular mechanism in oxidative stress response. Proc Natl Acad Sci U S A. 2020 06 30; 117(26):14958-14969.Proc Natl Acad Sci U S A2020-06-15T00:00:002020E2F1 sumoylation as a protective cellular mechanism in oxidative stress response.Authorship 1298531Authorship 1298542Authorship 1298551Authorship 1298561Authorship 1298571Authorship 1298581Authorship 1298591Authorship 1298603Authorship 1298612Authorship 117721320142007America’s Top Doctors (Hematology), Castle Connolly Medical Ltd.20112007America’s Top Doctors for Cancer, Castle Connolly Medical Ltd.1998American Society of Hematology Fellow Scholar AwardNational Taiwan University19861979Book Coupon Awards, National Taiwan University College of MedicineAuthorship 1008345333408251Xiao Y, Lin FT, Lin WCProceedings of the National Academy of Sciences of the United States of AmericaACTL6A promotes repair of cisplatin-induced DNA damage, a new mechanism of platinum resistance in cancer. Proc Natl Acad Sci U S A. 2021 01 19; 118(3).Proc Natl Acad Sci U S A2021-01-19T00:00:002021ACTL6A promotes repair of cisplatin-induced DNA damage, a new mechanism of platinum resistance in cancer.Authorship 1010728433556369Liu K, Graves JD, Lin FT, Lin WCThe Journal of biological chemistryOverexpression of TopBP1, a canonical ATR/Chk1 activator, paradoxically hinders ATR/Chk1 activation in cancer. J Biol Chem. 2021 Jan-Jun; 296:100382.J Biol Chem2021-02-05T00:00:002021Overexpression of TopBP1, a canonical ATR/Chk1 activator, paradoxically hinders ATR/Chk1 activation in cancer.Authorship 1010779Weei-Chin Lin, Pinki Chowdhury, Gregory E. Lin, Kang Liu, Yongcheng Song, Fang-Tsyr LinMethod of treating cancer that overexpresses TopBP1Method of treating cancer that overexpresses TopBP1. 2017.2017-05-02T00:00:002017Method of treating cancer that overexpresses TopBP1Authorship 1206323true1InstructorInstructorAuthorship 1017774933953465Turin CG, Ting K, Bradshaw A, Dunham SR, Nunez-Wallace K, Patel SM, Dangayach P, Holdener S, Lin WCProceedings (Baylor University. Medical Center)Central nervous system intravascular lymphoma leading to rapidly progressive dementia. Proc (Bayl Univ Med Cent). 2021 Jan 11; 34(3):373-375.Proc (Bayl Univ Med Cent)2021-01-11T00:00:002021Central nervous system intravascular lymphoma leading to rapidly progressive dementia.true1Associate ProfessorAssociate Professor11459832Lin WC, Lin FT, Nevins JRGenes & developmentSelective induction of E2F1 in response to DNA damage, mediated by ATM-dependent phosphorylation. Genes Dev. 2001 Jul 15; 15(14):1833-44.Genes Dev2001-07-15T00:00:002001Selective induction of E2F1 in response to DNA damage, mediated by ATM-dependent phosphorylation.8787617Desiderio S, Lin WC, Li ZCurrent topics in microbiology and immunologyThe cell cycle and V(D)J recombination. Curr Top Microbiol Immunol. 1996; 217:45-59.Curr Top Microbiol Immunol1996-01-01T00:00:001996The cell cycle and V(D)J recombination.8146183Lin WC, Desiderio SProceedings of the National Academy of Sciences of the United States of AmericaCell cycle regulation of V(D)J recombination-activating protein RAG-2. Proc Natl Acad Sci U S A. 1994 Mar 29; 91(7):2733-7.Proc Natl Acad Sci U S A1994-03-29T00:00:001994Cell cycle regulation of V(D)J recombination-activating protein RAG-2.8493533Lin WC, Desiderio SScience (New York, N.Y.)Regulation of V(D)J recombination activator protein RAG-2 by phosphorylation. Science. 1993 May 14; 260(5110):953-9.Science1993-05-14T00:00:001993Regulation of V(D)J recombination activator protein RAG-2 by phosphorylation.10871822Lin WC, Telen MJMedical oncology (Northwood, London, England)Cardiac metastasis from a transitional cell carcinoma: a case report. Med Oncol. 2000 May; 17(2):147-50.Med Oncol2000-05-01T00:00:002000Cardiac metastasis from a transitional cell carcinoma: a case report.10221519Lin WC, Moore JO, Mann KP, Traweek ST, Smith CLeukemia & lymphomaPost transplant CD8+ gammadelta T-cell lymphoma associated with human herpes virus-6 infection. Leuk Lymphoma. 1999 Apr; 33(3-4):377-84.Leuk Lymphoma1999-04-01T00:00:001999Post transplant CD8+ gammadelta T-cell lymphoma associated with human herpes virus-6 infection.7662097Lin WC, Desiderio SImmunology todayV(D)J recombination and the cell cycle. Immunol Today. 1995 Jun; 16(6):279-89.Immunol Today1995-06-01T00:00:001995V(D)J recombination and the cell cycle.8413222Oltz EM, Alt FW, Lin WC, Chen J, Taccioli G, Desiderio S, Rathbun GMolecular and cellular biologyA V(D)J recombinase-inducible B-cell line: role of transcriptional enhancer elements in directing V(D)J recombination. Mol Cell Biol. 1993 Oct; 13(10):6223-30.Mol Cell Biol1993-10-01T00:00:001993A V(D)J recombinase-inducible B-cell line: role of transcriptional enhancer elements in directing V(D)J recombination.2407296Lin LY, Lin WC, Huang PCBiochimica et biophysica actaPigeon metallothionein consists of two species. Biochim Biophys Acta. 1990 Feb 09; 1037(2):248-55.Biochim Biophys Acta1990-02-09T00:00:001990Pigeon metallothionein consists of two species.Authorship 1024421434218139Liu K, Graves JD, Lin FT, Lin WCThe Journal of biological chemistryCorrection: Overexpression of TopBP1, a canonical ATR/Chk1 activator, paradoxically hinders ATR/Chk1 activation in?cancer. J Biol Chem. 2021 Jul; 297(1):100924.J Biol Chem2021-07-01T00:00:002021Correction: Overexpression of TopBP1, a canonical ATR/Chk1 activator, paradoxically hinders ATR/Chk1 activation in?cancer.Authorship 1027743634400221Ho SR, Lee YC, Ittmann MM, Lin FT, Chan KS, Lin WCCancer lettersRNF144A deficiency promotes PD-L1 protein stabilization and carcinogen-induced bladder tumorigenesis. Cancer Lett. 2021 11 01; 520:344-360.Cancer Lett2021-08-13T00:00:002021RNF144A deficiency promotes PD-L1 protein stabilization and carcinogen-induced bladder tumorigenesis.Authorship 137858524081328Liu K, Graves JD, Scott JD, Li R, Lin WCMolecular and cellular biologyAkt switches TopBP1 function from checkpoint activation to transcriptional regulation through phosphoserine binding-mediated oligomerization. Mol Cell Biol. 2013 Dec; 33(23):4685-700.Mol Cell Biol2013-09-30T00:00:002013Akt switches TopBP1 function from checkpoint activation to transcriptional regulation through phosphoserine binding-mediated oligomerization.Rivkin Center for Ovarian Cancer20172016Pilot Study AwardRivkin Center for Ovarian Cancer20232021Pilot Study AwardPrincipal InvestigatorPrincipal InvestigatorPrincipal InvestigatorPrincipal InvestigatorPrincipal InvestigatorPrincipal InvestigatorPrincipal InvestigatorPrincipal InvestigatorPrincipal InvestigatorPrincipal InvestigatorPrincipal InvestigatorPrincipal InvestigatorPrincipal Investigator2027-01-31NIH/NCILIN, WEEI-CHIN2022-02-01Novel therapeutics for targeting checkpoint dysfunction in cancer2R01CA203824-06A12018-09-29Department of Defense Breast Cancer Research Program Breakthrough Award 2 –Funding Level 2LIN, WEEI-CHIN2014-09-30Targeting a convergent point of multiple oncogenic pathways in breast cancer, a new paradigm for targeted therapyBC1336782008-03-24Department of DefenseLIN, WEEI-CHIN2004-03-25The Role of TopBP1 in Breast CancerBC0319622023-03-31Rivkin Center for Ovarian Cancer Pilot AwardLIN, WEEI-CHIN2021-04-01Novel approaches to target MYC in ovarian cancerPilot Award2023-07-31Department of Defense Breast Cancer Research Program Expansion AwardLIN, WEEI-CHIN2019-08-01Title: Inducing BRCAness to synergize with PARP inhibitors in breast cancerBC1811042025-05-14Department of Defense Breast Cancer Research Program Expansion AwardLIN, WEEI-CHIN2022-05-15Novel Synthetic Lethal Therapies for Triple-Negative Breast CancerBC2108632017-09-14Department of Defense Ovarian Cancer Research ProgramLIN, WEEI-CHIN2014-09-15Novel approaches to target mutant p53 gain-of-function in ovarian cancerOC1303952017-03-31Rivkin Center for Ovarian CancerLIN, WEEI-CHIN2016-04-01Target a new mechanism of checkpoint defect in ovarian cancerPilot Award2024-07-31Department of Defense Lung Cancer Research Program Idea Development Award-Established InvestigatorLIN, WEEI-CHIN2022-08-01New therapeutics targeting MYC and immune escape in lung cancerLC2103692005-01-07General Motors Cancer Research Scholars ProgramLIN, WEEI-CHIN2002-01-07Regulation of E2F1 by ATMGeneral Motors Cancer Research Scholar2011-06-30The Leukemia & Lymphoma SocietyLIN, WEEI-CHIN2006-07-01The function and regulation of TopBP1 in growth and DNA damage responseThe Leukemia & Lymphoma Society Scholar Award2022-09-29Department of Defense Breast Cancer Research Program Breakthrough Award 2 –Funding Level 2LIN, WEEI-CHIN2018-09-30Exploiting a new Achilles’ heel of mutant p53 in breast cancerBC1713962014-03-31Department of Defense Breast Cancer Research ProgramLIN, WEEI-CHIN2009-06-01Regulation of p21 turnover by 14-3-3tau: a basis for novel therapeutic strategies against breast cancerBC084561true1Faculty ClinicianFaculty ClinicianAuthorship 1053217336252018Garan LAW, Xiao Y, Lin WCProceedings of the National Academy of Sciences of the United States of America14-3-3t drives estrogen receptor loss via ERa36 induction and GATA3 inhibition in breast cancer. Proc Natl Acad Sci U S A. 2022 10 25; 119(43):e2209211119.Proc Natl Acad Sci U S A2022-10-17T00:00:00202214-3-3t drives estrogen receptor loss via ERa36 induction and GATA3 inhibition in breast cancer.Authorship 1054072136469785Lin WC, Lin FTProceedings of the National Academy of Sciences of the United States of AmericaSuper-enhanced MARCO variant drives triple-negative breast cancer progression. Proc Natl Acad Sci U S A. 2022 12 13; 119(50):e2217953119.Proc Natl Acad Sci U S A2022-12-05T00:00:002022Super-enhanced MARCO variant drives triple-negative breast cancer progression.Principal Investigator2028-03-31NIH/NCILIN, WEEI-CHIN2023-04-1714-3-3tau drives estrogen receptor loss and breast cancer progression1R01CA269971-01A1true1Distinguished Service Professor EmeritusDistinguished Service Professor Emeritustrue1ProfessorProfessorDepartment of Biochemistry and Molecular PharmacologyBiochemistry & Mol PharmacologyAuthorship 10796975Authorship 1079698637737056Chen SM, Phuc PT, Nguyen PA, Burton W, Lin SJ, Lin WC, Lu CY, Hsu MH, Cheng CT, Hsu JCCancer medicineA novel prediction model of the risk of pancreatic cancer among diabetes patients using multiple clinical data and machine learning. Cancer Med. 2023 10; 12(19):19987-19999.Cancer Med2023-09-22T00:00:002023A novel prediction model of the risk of pancreatic cancer among diabetes patients using multiple clinical data and machine learning.37756561Folly-Kossi H, Graves JD, Garan LAW, Lin FT, Lin WCCancer research communicationsDNA2 Nuclease Inhibition Confers Synthetic Lethality in Cancers with Mutant p53 and Synergizes with PARP Inhibitors. Cancer Res Commun. 2023 10 16; 3(10):2096-2112.Cancer Res Commun2023-10-16T00:00:002023DNA2 Nuclease Inhibition Confers Synthetic Lethality in Cancers with Mutant p53 and Synergizes with PARP Inhibitors.Authorship 10797025Authorship 1079703536140253Lin WK, Lin SJ, Lee WR, Lin CC, Lin WC, Chang HC, Cheng CT, Hsu JCBiomedicinesEffectiveness and Safety of Immunosuppressants and Biological Therapy for Chronic Spontaneous Urticaria: A Network Meta-Analysis. Biomedicines. 2022 Sep 01; 10(9).Biomedicines2022-09-01T00:00:002022Effectiveness and Safety of Immunosuppressants and Biological Therapy for Chronic Spontaneous Urticaria: A Network Meta-Analysis.36359190Liu SD, Lin SJ, Ray CY, Lin FT, Lin WC, Wang LHBiomedicinesAssociations of Warfarin Use with Risks of Ischemic Cerebrovascular Events and Major Bleeding in Patients with Hyperthyroidism-Related Atrial Fibrillation. Biomedicines. 2022 Oct 22; 10(11).Biomedicines2022-10-22T00:00:002022Associations of Warfarin Use with Risks of Ischemic Cerebrovascular Events and Major Bleeding in Patients with Hyperthyroidism-Related Atrial Fibrillation.true1Adjunct Associate ProfessorAdjunct Associate ProfessorAuthorship 1082084737878724Lin FT, Liu K, Garan LAW, Folly-Kossi H, Song Y, Lin SJ, Lin WCProceedings of the National Academy of Sciences of the United States of AmericaA small-molecule inhibitor of TopBP1 exerts anti-MYC activity and synergy with PARP inhibitors. Proc Natl Acad Sci U S A. 2023 Oct 31; 120(44):e2307793120.Proc Natl Acad Sci U S A2023-10-25T00:00:002023A small-molecule inhibitor of TopBP1 exerts anti-MYC activity and synergy with PARP inhibitors.true1ProfessorProfessorPrincipal Investigator2027-02-28Department of Defense Breast Cancer Research Program Breakthrough Award 2 –Funding Level 2LIN, WEEI-CHIN2024-03-01Synthetic Lethal Combination Targeting TopBP1 and Arachidonic Acid Pathway in Breast CancerBC230488true1ProfessorProfessortrue1ProfessorProfessortrue1ProfessorProfessortrue1ProfessorProfessortrue1ProfessorProfessorAuthorship 139725624820414Xiao Y, Lin VY, Ke S, Lin GE, Lin FT, Lin WCMolecular and cellular biology14-3-3t promotes breast cancer invasion and metastasis by inhibiting RhoGDIa. Mol Cell Biol. 2014 Jul; 34(14):2635-49.Mol Cell Biol2014-07-01T00:00:00201414-3-3t promotes breast cancer invasion and metastasis by inhibiting RhoGDIa.Authorship 344562Authorship 391904Authorship 146699424979766Ho SR, Mahanic CS, Lee YJ, Lin WCProceedings of the National Academy of Sciences of the United States of AmericaRNF144A, an E3 ubiquitin ligase for DNA-PKcs, promotes apoptosis during DNA damage. Proc Natl Acad Sci U S A. 2014 Jul 01; 111(26):E2646-55.Proc Natl Acad Sci U S A2014-06-16T00:00:002014RNF144A, an E3 ubiquitin ligase for DNA-PKcs, promotes apoptosis during DNA damage.Authorship 46575Authorship 641055Baylor College of Medicine2012Breast SPORE Translational Research AwardBaylor College of Medicine2013Dan L. Duncan Cancer Center pilot project awardNIH/NCI20192014BCM Oncology Scholars Training Program (T32)Authorship 704926Authorship 793553Authorship 153480625400145Chowdhury P, Lin GE, Liu K, Song Y, Lin FT, Lin WCNature communicationsTargeting TopBP1 at a convergent point of multiple oncogenic pathways for cancer therapy. Nat Commun. 2014 Nov 17; 5:5476.Nat Commun2014-11-17T00:00:002014Targeting TopBP1 at a convergent point of multiple oncogenic pathways for cancer therapy.