Co-Authors
This is a "connection" page, showing publications co-authored by STEPHEN PFLUGFELDER and CINTIA DE PAIVA.
Connection Strength
18.479
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Differentially Expressed Gene Pathways in the Conjunctiva of Sj?gren Syndrome Keratoconjunctivitis Sicca. Front Immunol. 2021; 12:702755.
Score: 0.698
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Goblet cells promote tolerance induction in the conjunctiva. Mucosal Immunol. 2020 09; 13(5):717-718.
Score: 0.649
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Mechanisms of Disease in Sj?gren Syndrome-New Developments and Directions. Int J Mol Sci. 2020 Jan 19; 21(2).
Score: 0.629
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Severity of Sj?gren's Syndrome Keratoconjunctivitis Sicca Increases with Increased Percentage of Conjunctival Antigen-Presenting Cells. Int J Mol Sci. 2018 Sep 14; 19(9).
Score: 0.573
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The Pathophysiology of Dry Eye Disease: What We Know and Future Directions for Research. Ophthalmology. 2017 11; 124(11S):S4-S13.
Score: 0.539
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Altered Mucosal Microbiome Diversity and Disease Severity in Sj?gren Syndrome. Sci Rep. 2016 Apr 18; 6:23561.
Score: 0.485
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T helper cytokines in dry eye disease. Exp Eye Res. 2013 Dec; 117:118-25.
Score: 0.404
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Disruption of TGF-? signaling improves ocular surface epithelial disease in experimental autoimmune keratoconjunctivitis sicca. PLoS One. 2011; 6(12):e29017.
Score: 0.359
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Homeostatic control of conjunctival mucosal goblet cells by NKT-derived IL-13. Mucosal Immunol. 2011 Jul; 4(4):397-408.
Score: 0.335
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Age-related T-cell cytokine profile parallels corneal disease severity in Sjogren's syndrome-like keratoconjunctivitis sicca in CD25KO mice. Rheumatology (Oxford). 2010 Feb; 49(2):246-58.
Score: 0.312
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Essential role for c-Jun N-terminal kinase 2 in corneal epithelial response to desiccating stress. Arch Ophthalmol. 2009 Dec; 127(12):1625-31.
Score: 0.312
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Cleavage of functional IL-2 receptor alpha chain (CD25) from murine corneal and conjunctival epithelia by MMP-9. J Inflamm (Lond). 2009 Oct 31; 6:31.
Score: 0.310
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IL-17 disrupts corneal barrier following desiccating stress. Mucosal Immunol. 2009 May; 2(3):243-53.
Score: 0.295
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Rationale for anti-inflammatory therapy in dry eye syndrome. Arq Bras Oftalmol. 2008 Nov-Dec; 71(6 Suppl):89-95.
Score: 0.289
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Dry eye-induced conjunctival epithelial squamous metaplasia is modulated by interferon-gamma. Invest Ophthalmol Vis Sci. 2007 Jun; 48(6):2553-60.
Score: 0.262
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Oral administration of probiotic Limosilactobacillus reuteri DSM 17938 suppresses dry eye disease in the desiccating stress mouse model. Ocul Surf. 2026 Aug 19; 42:243-256.
Score: 0.248
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Apical corneal barrier disruption in experimental murine dry eye is abrogated by methylprednisolone and doxycycline. Invest Ophthalmol Vis Sci. 2006 Jul; 47(7):2847-56.
Score: 0.246
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Modulation of corneal sensory processing and pain responses by dry eye and corneal wounding. Front Cell Neurosci. 2026; 20:1767673.
Score: 0.244
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Corticosteroid and doxycycline suppress MMP-9 and inflammatory cytokine expression, MAPK activation in the corneal epithelium in experimental dry eye. Exp Eye Res. 2006 Sep; 83(3):526-35.
Score: 0.243
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The incidence and risk factors for developing dry eye after myopic LASIK. Am J Ophthalmol. 2006 Mar; 141(3):438-45.
Score: 0.240
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Investigating conjunctival immune pathways in Sj?gren and non-Sj?gren disease associated dry eye. Ocul Surf. 2026 04; 40:52-62.
Score: 0.239
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Changes in conjunctival mononuclear phagocytes and suppressive activity of regulatory macrophages in desiccation induced dry eye. Ocul Surf. 2024 10; 34:348-362.
Score: 0.217
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Tear clearance implications for ocular surface health. Exp Eye Res. 2004 Mar; 78(3):395-7.
Score: 0.209
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Corneal epitheliopathy of dry eye induces hyperesthesia to mechanical air jet stimulation. Am J Ophthalmol. 2004 Jan; 137(1):109-15.
Score: 0.207
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Assessing the severity of keratitis sicca with videokeratoscopic indices. Ophthalmology. 2003 Jun; 110(6):1102-9.
Score: 0.198
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Differentially Expressed Tear Proteins in Sj?gren's Syndrome Keratoconjunctivitis Sicca. Transl Vis Sci Technol. 2023 06 01; 12(6):8.
Score: 0.198
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Induction of Innate Inflammatory Pathways in the Corneal Epithelium in the Desiccating Stress Dry Eye Model. Invest Ophthalmol Vis Sci. 2023 04 03; 64(4):8.
Score: 0.196
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Keratoconus-like topographic changes in keratoconjunctivitis sicca. Cornea. 2003 Jan; 22(1):22-4.
Score: 0.193
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Author Correction: Gut-derived butyrate suppresses ocular surface inflammation. Sci Rep. 2022 Apr 21; 12(1):6581.
Score: 0.184
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Single-cell transcriptional profiling of murine conjunctival immune cells reveals distinct populations expressing homeostatic and regulatory genes. Mucosal Immunol. 2022 04; 15(4):620-628.
Score: 0.183
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IL-17 Producing Lymphocytes Cause Dry Eye and Corneal Disease With Aging in RXRa Mutant Mouse. Front Med (Lausanne). 2022; 9:849990.
Score: 0.183
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Gut-derived butyrate suppresses ocular surface inflammation. Sci Rep. 2022 03 16; 12(1):4512.
Score: 0.183
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Gut Microbiota From Sj?gren syndrome Patients Causes Decreased T Regulatory Cells in the Lymphoid Organs and Desiccation-Induced Corneal Barrier Disruption in Mice. Front Med (Lausanne). 2022; 9:852918.
Score: 0.182
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Desiccation Induced Conjunctival Monocyte Recruitment and Activation - Implications for Keratoconjunctivitis. Front Immunol. 2021; 12:701415.
Score: 0.174
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Retinoid Regulation of Ocular Surface Innate Inflammation. Int J Mol Sci. 2021 Jan 22; 22(3).
Score: 0.169
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Calcineurin Inhibitor Voclosporin Preserves Corneal Barrier and Conjunctival Goblet Cells in Experimental Dry Eye. J Ocul Pharmacol Ther. 2020 11; 36(9):679-685.
Score: 0.163
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Regional Comparison of Goblet Cell Number and Area in Exposed and Covered Dry Eyes and Their Correlation with Tear MUC5AC. Sci Rep. 2020 02 19; 10(1):2933.
Score: 0.158
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Immune - Goblet cell interaction in the conjunctiva. Ocul Surf. 2020 04; 18(2):326-334.
Score: 0.157
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The gut-eye-lacrimal gland-microbiome axis in Sj?gren Syndrome. Ocul Surf. 2020 04; 18(2):335-344.
Score: 0.155
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Dysbiosis Modulates Ocular Surface Inflammatory Response to Liposaccharide. Invest Ophthalmol Vis Sci. 2019 10 01; 60(13):4224-4233.
Score: 0.154
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Topical cyclosporine A therapy for dry eye syndrome. Cochrane Database Syst Rev. 2019 09 13; 9:CD010051.
Score: 0.153
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Age-associated antigen-presenting cell alterations promote dry-eye inducing Th1 cells. Mucosal Immunol. 2019 07; 12(4):897-908.
Score: 0.147
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Reduced Corneal Innervation in the CD25 Null Model of Sj?gren Syndrome. Int J Mol Sci. 2018 Nov 30; 19(12).
Score: 0.145
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Goblet cell-produced retinoic acid suppresses CD86 expression and IL-12 production in bone marrow-derived cells. Int Immunol. 2018 09 25; 30(10):457-470.
Score: 0.143
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Suppression of Th1-Mediated Keratoconjunctivitis Sicca by Lifitegrast. J Ocul Pharmacol Ther. 2018 09; 34(7):543-549.
Score: 0.141
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Protective role of commensal bacteria in Sj?gren Syndrome. J Autoimmun. 2018 09; 93:45-56.
Score: 0.141
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Sj?gren-Like Lacrimal Keratoconjunctivitis in Germ-Free Mice. Int J Mol Sci. 2018 Feb 13; 19(2).
Score: 0.138
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Goblet cell loss abrogates ocular surface immune tolerance. JCI Insight. 2018 02 08; 3(3).
Score: 0.137
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Reduced intraepithelial corneal nerve density and sensitivity accompany desiccating stress and aging in C57BL/6 mice. Exp Eye Res. 2018 04; 169:91-98.
Score: 0.137
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Goblet Cells Contribute to Ocular Surface Immune Tolerance-Implications for Dry Eye Disease. Int J Mol Sci. 2017 May 05; 18(5).
Score: 0.130
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Inhibition of NLRP3 Inflammasome Pathway by Butyrate Improves Corneal Wound Healing in Corneal Alkali Burn. Int J Mol Sci. 2017 Mar 05; 18(3).
Score: 0.129
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Age-related spontaneous lacrimal keratoconjunctivitis is accompanied by dysfunctional T regulatory cells. Mucosal Immunol. 2017 05; 10(3):743-756.
Score: 0.125
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Interferon-gamma deficiency protects against aging-related goblet cell loss. Oncotarget. 2016 10 04; 7(40):64605-64614.
Score: 0.125
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Dexamethasone Drug Eluting Nanowafers Control Inflammation in Alkali-Burned Corneas Associated With Dry Eye. Invest Ophthalmol Vis Sci. 2016 06 01; 57(7):3222-30.
Score: 0.122
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Inflammatory Response to Lipopolysaccharide on the Ocular Surface in a Murine Dry Eye Model. Invest Ophthalmol Vis Sci. 2016 05 01; 57(6):2443-51.
Score: 0.121
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Interferon-?-Induced Unfolded Protein Response in Conjunctival Goblet Cells as a Cause of Mucin Deficiency in Sj?gren Syndrome. Am J Pathol. 2016 06; 186(6):1547-58.
Score: 0.121
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MMP-8 Is Critical for Dexamethasone Therapy in Alkali-Burned Corneas Under Dry Eye Conditions. J Cell Physiol. 2016 11; 231(11):2506-16.
Score: 0.121
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Differential Effects of Dexamethasone and Doxycycline on Inflammation and MMP Production in Murine Alkali-Burned Corneas Associated with Dry Eye. Ocul Surf. 2016 04; 14(2):242-54.
Score: 0.119
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Aqueous Tear Deficiency Increases Conjunctival Interferon-? (IFN-?) Expression and Goblet Cell Loss. Invest Ophthalmol Vis Sci. 2015 Nov; 56(12):7545-50.
Score: 0.117
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Improvement of Outcome Measures of Dry Eye by a Novel Integrin Antagonist in the Murine Desiccating Stress Model. Invest Ophthalmol Vis Sci. 2015 Sep; 56(10):5888-95.
Score: 0.116
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Desiccating Stress-Induced MMP Production and Activity Worsens Wound Healing in Alkali-Burned Corneas. Invest Ophthalmol Vis Sci. 2015 Jul; 56(8):4908-18.
Score: 0.115
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IL-13 Stimulates Proliferation and Expression of Mucin and Immunomodulatory Genes in Cultured Conjunctival Goblet Cells. Invest Ophthalmol Vis Sci. 2015 Jul; 56(8):4186-97.
Score: 0.115
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Effects of Dry Eye Therapies on Environmentally Induced Ocular Surface Disease. Am J Ophthalmol. 2015 Jul; 160(1):135-42.e1.
Score: 0.113
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Age-Related Conjunctival Disease in the C57BL/6.NOD-Aec1Aec2 Mouse Model of Sj?gren Syndrome Develops Independent of Lacrimal Dysfunction. Invest Ophthalmol Vis Sci. 2015 Apr; 56(4):2224-33.
Score: 0.113
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Macrophage Phenotype in the Ocular Surface of Experimental Murine Dry Eye Disease. Arch Immunol Ther Exp (Warsz). 2015 Aug; 63(4):299-304.
Score: 0.112
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Altered balance of interleukin-13/interferon-gamma contributes to lacrimal gland destruction and secretory dysfunction in CD25 knockout model of Sj?gren's syndrome. Arthritis Res Ther. 2015 Mar 10; 17:53.
Score: 0.112
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Desiccating stress-induced chemokine expression in the epithelium is dependent on upregulation of NKG2D/RAE-1 and release of IFN-? in experimental dry eye. J Immunol. 2014 Nov 15; 193(10):5264-72.
Score: 0.109
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Ocular surface disease and dacryoadenitis in aging C57BL/6 mice. Am J Pathol. 2014 Mar; 184(3):631-43.
Score: 0.103
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Topical interferon-gamma neutralization prevents conjunctival goblet cell loss in experimental murine dry eye. Exp Eye Res. 2014 Jan; 118:117-24.
Score: 0.103
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Chemokine receptors CCR6 and CXCR3 are necessary for CD4(+) T cell mediated ocular surface disease in experimental dry eye disease. PLoS One. 2013; 8(11):e78508.
Score: 0.102
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CD8? cells regulate the T helper-17 response in an experimental murine model of Sj?gren syndrome. Mucosal Immunol. 2014 Mar; 7(2):417-27.
Score: 0.101
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Dendritic cell-derived thrombospondin-1 is critical for the generation of the ocular surface Th17 response to desiccating stress. J Leukoc Biol. 2013 Dec; 94(6):1293-301.
Score: 0.101
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Factors predicting the ocular surface response to desiccating environmental stress. Invest Ophthalmol Vis Sci. 2013 May 07; 54(5):3325-32.
Score: 0.099
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Deletion of interferon-? delays onset and severity of dacryoadenitis in CD25KO mice. Arthritis Res Ther. 2012 Nov 01; 14(6):R234.
Score: 0.095
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Resolvin E1 (RX-10001) reduces corneal epithelial barrier disruption and protects against goblet cell loss in a murine model of dry eye. Cornea. 2012 Nov; 31(11):1299-303.
Score: 0.095
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NK cells promote Th-17 mediated corneal barrier disruption in dry eye. PLoS One. 2012; 7(5):e36822.
Score: 0.092
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Autoantibodies contribute to the immunopathogenesis of experimental dry eye disease. Invest Ophthalmol Vis Sci. 2012 Apr 24; 53(4):2062-75.
Score: 0.092
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Low humidity environmental challenge causes barrier disruption and cornification of the mouse corneal epithelium via a c-jun N-terminal kinase 2 (JNK2) pathway. Exp Eye Res. 2012 Jan; 94(1):150-6.
Score: 0.090
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Biodegradable PLGA-Based Drug Delivery Systems for Modulating Ocular Surface Disease under Experimental Murine Dry Eye. J Clin Exp Ophthalmol. 2011 Nov 01; 2(11).
Score: 0.089
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Desiccating stress induces CD4+ T-cell-mediated Sj?gren's syndrome-like corneal epithelial apoptosis via activation of the extrinsic apoptotic pathway by interferon-?. Am J Pathol. 2011 Oct; 179(4):1807-14.
Score: 0.088
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Interferon-? exacerbates dry eye-induced apoptosis in conjunctiva through dual apoptotic pathways. Invest Ophthalmol Vis Sci. 2011 Aug 09; 52(9):6279-85.
Score: 0.088
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Entrapment of conjunctival goblet cells by desiccation-induced cornification. Invest Ophthalmol Vis Sci. 2011 Jun 01; 52(6):3492-9.
Score: 0.086
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Pharmacological cholinergic blockade stimulates inflammatory cytokine production and lymphocytic infiltration in the mouse lacrimal gland. Invest Ophthalmol Vis Sci. 2011 May 16; 52(6):3221-7.
Score: 0.086
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Evaluation of the transforming growth factor-beta activity in normal and dry eye human tears by CCL-185 cell bioassay. Cornea. 2010 Sep; 29(9):1048-54.
Score: 0.082
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Spontaneous autoimmune dacryoadenitis in aged CD25KO mice. Am J Pathol. 2010 Aug; 177(2):744-53.
Score: 0.081
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Desiccating stress promotion of Th17 differentiation by ocular surface tissues through a dendritic cell-mediated pathway. Invest Ophthalmol Vis Sci. 2010 Jun; 51(6):3083-91.
Score: 0.079
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Spontaneous T cell mediated keratoconjunctivitis in Aire-deficient mice. Br J Ophthalmol. 2009 Sep; 93(9):1260-4.
Score: 0.075
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Production and activity of matrix metalloproteinase-9 on the ocular surface increase in dysfunctional tear syndrome. Invest Ophthalmol Vis Sci. 2009 Jul; 50(7):3203-9.
Score: 0.074
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Tear cytokine profiles in dysfunctional tear syndrome. Am J Ophthalmol. 2009 Feb; 147(2):198-205. e1.
Score: 0.072
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Glial cell-derived neurotrophic factor gene delivery enhances survival of human corneal epithelium in culture and the overexpression of GDNF in bioengineered constructs. Exp Eye Res. 2008 Dec; 87(6):580-6.
Score: 0.072
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Desiccating stress decreases apical corneal epithelial cell size--modulation by the metalloproteinase inhibitor doxycycline. Cornea. 2008 Sep; 27(8):935-40.
Score: 0.071
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Epithelial-immune cell interaction in dry eye. Cornea. 2008 Sep; 27 Suppl 1:S9-11.
Score: 0.071
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Effects of sequential artificial tear and cyclosporine emulsion therapy on conjunctival goblet cell density and transforming growth factor-beta2 production. Cornea. 2008 Jan; 27(1):64-9.
Score: 0.068
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Desiccating environmental stress exacerbates autoimmune lacrimal keratoconjunctivitis in non-obese diabetic mice. J Autoimmun. 2008 Jun; 30(4):212-21.
Score: 0.067
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Expression of Th-1 chemokines and chemokine receptors on the ocular surface of C57BL/6 mice: effects of desiccating stress. Invest Ophthalmol Vis Sci. 2007 Jun; 48(6):2561-9.
Score: 0.065
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Transglutaminase participates in UVB-induced cell death pathways in human corneal epithelial cells. Invest Ophthalmol Vis Sci. 2006 Oct; 47(10):4295-301.
Score: 0.063
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Desiccating stress stimulates expression of matrix metalloproteinases by the corneal epithelium. Invest Ophthalmol Vis Sci. 2006 Aug; 47(8):3293-302.
Score: 0.062
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Topical cyclosporine A therapy for dry eye disease. Cochrane Database Syst Rev. 2026 07 17; 7:CD010051.
Score: 0.062
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Corneal Innervation Research at a Crossroads: A Tool-Driven Roadmap for the Future. Invest Ophthalmol Vis Sci. 2026 06 01; 67(6):25.
Score: 0.061
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Expression and regulation of cornified envelope proteins in human corneal epithelium. Invest Ophthalmol Vis Sci. 2006 May; 47(5):1938-46.
Score: 0.061
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Stress-activated protein kinase signaling pathways in dry eye and ocular surface disease. Ocul Surf. 2005 Oct; 3(4 Suppl):S154-7.
Score: 0.058
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Cell size correlates with phenotype and proliferative capacity in human corneal epithelial cells. Stem Cells. 2006 Feb; 24(2):368-75.
Score: 0.058
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Partial enrichment of a population of human limbal epithelial cells with putative stem cell properties based on collagen type IV adhesiveness. Exp Eye Res. 2005 Apr; 80(4):581-90.
Score: 0.056
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Destructive and protective effects and therapeutic targets of IL-36 family cytokines in dry eye disease. Ocul Surf. 2025 04; 36:83-93.
Score: 0.055
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ABCG2 transporter identifies a population of clonogenic human limbal epithelial cells. Stem Cells. 2005; 23(1):63-73.
Score: 0.055
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Matrix metalloproteinase-9 knockout confers resistance to corneal epithelial barrier disruption in experimental dry eye. Am J Pathol. 2005 Jan; 166(1):61-71.
Score: 0.055
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Mouse Corneal Immune Cell Heterogeneity Revealed by Single-Cell RNA Sequencing. Invest Ophthalmol Vis Sci. 2024 10 01; 65(12):29.
Score: 0.054
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A randomized, double-masked, placebo-controlled, multicenter comparison of loteprednol etabonate ophthalmic suspension, 0.5%, and placebo for treatment of keratoconjunctivitis sicca in patients with delayed tear clearance. Am J Ophthalmol. 2004 Sep; 138(3):444-57.
Score: 0.054
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Ectoine, from a Natural Bacteria Protectant to a New Treatment of Dry Eye Disease. Pharmaceutics. 2024 Feb 05; 16(2).
Score: 0.052
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Imbalanced IL-37/TNF-a/CTSS signaling disrupts corneal epithelial barrier in a dry eye model in vitro. Ocul Surf. 2022 10; 26:234-243.
Score: 0.047
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Rapamycin Eyedrops Increased CD4+Foxp3+ Cells and Prevented Goblet Cell Loss in the Aged Ocular Surface. Int J Mol Sci. 2020 Nov 24; 21(23).
Score: 0.042
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IL-33/ST2/IL-9/IL-9R signaling disrupts ocular surface barrier in allergic inflammation. Mucosal Immunol. 2020 11; 13(6):919-930.
Score: 0.040
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IL-27 signaling deficiency develops Th17-enhanced Th2-dominant inflammation in murine allergic conjunctivitis model. Allergy. 2019 05; 74(5):910-921.
Score: 0.037
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Mitochondrial DNA oxidation induces imbalanced activity of NLRP3/NLRP6 inflammasomes by activation of caspase-8 and BRCC36 in dry eye. J Autoimmun. 2017 Jun; 80:65-76.
Score: 0.032
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Dexamethasone nanowafer as an effective therapy for dry eye disease. J Control Release. 2015 Sep 10; 213:168-174.
Score: 0.029
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A potential link between bacterial pathogens and allergic conjunctivitis by dendritic cells. Exp Eye Res. 2014 Mar; 120:118-26.
Score: 0.026
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Effect of desiccating stress on mouse meibomian gland function. Ocul Surf. 2014 Jan; 12(1):59-68.
Score: 0.025
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Morphologic alterations of the palpebral conjunctival epithelium in a dry eye model. Cornea. 2013 Apr; 32(4):483-90.
Score: 0.025
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Potential autocrine regulation of interleukin-33/ST2 signaling of dendritic cells in allergic inflammation. Mucosal Immunol. 2013 Sep; 6(5):921-30.
Score: 0.024
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A native-like corneal construct using donor corneal stroma for tissue engineering. PLoS One. 2012; 7(11):e49571.
Score: 0.024
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Ocular surface APCs are necessary for autoreactive T cell-mediated experimental autoimmune lacrimal keratoconjunctivitis. J Immunol. 2011 Oct 01; 187(7):3653-62.
Score: 0.022
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Short ragweed pollen triggers allergic inflammation through Toll-like receptor 4-dependent thymic stromal lymphopoietin/OX40 ligand/OX40 signaling pathways. J Allergy Clin Immunol. 2011 Dec; 128(6):1318-1325.e2.
Score: 0.022
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TSLP and downstream molecules in experimental mouse allergic conjunctivitis. Invest Ophthalmol Vis Sci. 2010 Jun; 51(6):3076-82.
Score: 0.020
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Induction of Th17 differentiation by corneal epithelial-derived cytokines. J Cell Physiol. 2010 Jan; 222(1):95-102.
Score: 0.020
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Patterned expression of neurotrophic factors and receptors in human limbal and corneal regions. Mol Vis. 2007 Oct 16; 13:1934-41.
Score: 0.017
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Desiccating stress induces T cell-mediated Sj?gren's Syndrome-like lacrimal keratoconjunctivitis. J Immunol. 2006 Apr 01; 176(7):3950-7.
Score: 0.015
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Phenotypic characterization of human corneal epithelial cells expanded ex vivo from limbal explant and single cell cultures. Exp Eye Res. 2004 Jul; 79(1):41-9.
Score: 0.013
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Characterization of putative stem cell phenotype in human limbal epithelia. Stem Cells. 2004; 22(3):355-66.
Score: 0.013