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STEPHEN PFLUGFELDER to Tears

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This is a "connection" page, showing publications STEPHEN PFLUGFELDER has written about Tears.
STEPHEN PFLUGFELDER
Connection Strength
17.667
Tears
  1. Non-Invasive Tear Break-Up Detection with the Kowa DR-1a and Its Relationship to Dry Eye Clinical Severity. Int J Mol Sci. 2022 Nov 25; 23(23).
    View in: PubMed
    Score: 0.746
  2. Conjunctivochalasis and Tear Osmolarity Are Associated With Reduced Conjunctival Epithelial Thickness in Dry Eye. Am J Ophthalmol. 2021 07; 227:35-44.
    View in: PubMed
    Score: 0.659
  3. The cornea in keratoconjunctivitis sicca. Exp Eye Res. 2020 12; 201:108295.
    View in: PubMed
    Score: 0.644
  4. Biological functions of tear film. Exp Eye Res. 2020 08; 197:108115.
    View in: PubMed
    Score: 0.630
  5. Regional Comparison of Goblet Cell Number and Area in Exposed and Covered Dry Eyes and Their Correlation with Tear MUC5AC. Sci Rep. 2020 02 19; 10(1):2933.
    View in: PubMed
    Score: 0.616
  6. Randomized Controlled Crossover Trial Comparing the Impact of Sham or Intranasal Tear Neurostimulation on Conjunctival Goblet Cell Degranulation. Am J Ophthalmol. 2017 May; 177:159-168.
    View in: PubMed
    Score: 0.503
  7. Tear Volume-based Diagnostic Classification for Tear Dysfunction. Int Ophthalmol Clin. 2017; 57(2):1-12.
    View in: PubMed
    Score: 0.496
  8. Aqueous Tear Deficiency Increases Conjunctival Interferon-? (IFN-?) Expression and Goblet Cell Loss. Invest Ophthalmol Vis Sci. 2015 Nov; 56(12):7545-50.
    View in: PubMed
    Score: 0.457
  9. Corneal Sensitivity in Tear Dysfunction and its Correlation With Clinical Parameters and Blink Rate. Am J Ophthalmol. 2015 Nov; 160(5):858-866.e5.
    View in: PubMed
    Score: 0.450
  10. Age-Related Conjunctival Disease in the C57BL/6.NOD-Aec1Aec2 Mouse Model of Sj?gren Syndrome Develops Independent of Lacrimal Dysfunction. Invest Ophthalmol Vis Sci. 2015 Apr; 56(4):2224-33.
    View in: PubMed
    Score: 0.439
  11. New testing options for diagnosing and grading dry eye disease. Am J Ophthalmol. 2014 Jun; 157(6):1122-9.
    View in: PubMed
    Score: 0.408
  12. Tear meniscus dimensions in tear dysfunction and their correlation with clinical parameters. Am J Ophthalmol. 2014 Feb; 157(2):301-310.e1.
    View in: PubMed
    Score: 0.396
  13. Tear dysfunction and the cornea: LXVIII Edward Jackson Memorial Lecture. Am J Ophthalmol. 2011 Dec; 152(6):900-909.e1.
    View in: PubMed
    Score: 0.346
  14. Noninvasive assessment of tear stability with the tear stability analysis system in tear dysfunction patients. Invest Ophthalmol Vis Sci. 2011 Jan; 52(1):456-61.
    View in: PubMed
    Score: 0.328
  15. Evaluation of the transforming growth factor-beta activity in normal and dry eye human tears by CCL-185 cell bioassay. Cornea. 2010 Sep; 29(9):1048-54.
    View in: PubMed
    Score: 0.320
  16. Post-LASIK tear dysfunction and dysesthesia. Ocul Surf. 2010 Jul; 8(3):135-45.
    View in: PubMed
    Score: 0.316
  17. Expression of CXCL9, -10, -11, and CXCR3 in the tear film and ocular surface of patients with dry eye syndrome. Invest Ophthalmol Vis Sci. 2010 Feb; 51(2):643-50.
    View in: PubMed
    Score: 0.301
  18. Association between high tear epidermal growth factor levels and corneal subepithelial fibrosis in dry eye conditions. Invest Ophthalmol Vis Sci. 2010 Feb; 51(2):844-9.
    View in: PubMed
    Score: 0.300
  19. Production and activity of matrix metalloproteinase-9 on the ocular surface increase in dysfunctional tear syndrome. Invest Ophthalmol Vis Sci. 2009 Jul; 50(7):3203-9.
    View in: PubMed
    Score: 0.288
  20. Tear cytokine profiles in dysfunctional tear syndrome. Am J Ophthalmol. 2009 Feb; 147(2):198-205. e1.
    View in: PubMed
    Score: 0.282
  21. Strain-related cytokine profiles on the murine ocular surface in response to desiccating stress. Cornea. 2007 Jun; 26(5):579-84.
    View in: PubMed
    Score: 0.255
  22. Effect of topical ophthalmic epinastine and olopatadine on tear volume in mice. Eye Contact Lens. 2006 Dec; 32(6):272-6.
    View in: PubMed
    Score: 0.246
  23. Hyperosmolar saline is a proinflammatory stress on the mouse ocular surface. Eye Contact Lens. 2005 Sep; 31(5):186-93.
    View in: PubMed
    Score: 0.226
  24. Effect of experimental dry eye on tear sodium concentration in the mouse. Eye Contact Lens. 2005 Jul; 31(4):175-8.
    View in: PubMed
    Score: 0.223
  25. A randomized, double-masked, placebo-controlled, multicenter comparison of loteprednol etabonate ophthalmic suspension, 0.5%, and placebo for treatment of keratoconjunctivitis sicca in patients with delayed tear clearance. Am J Ophthalmol. 2004 Sep; 138(3):444-57.
    View in: PubMed
    Score: 0.211
  26. Tear clearance implications for ocular surface health. Exp Eye Res. 2004 Mar; 78(3):395-7.
    View in: PubMed
    Score: 0.204
  27. Immunologic basis for development of keratoconjunctivitis sicca in systemic autoimmune diseases: Role of innate immune sensors. Ocul Surf. 2024 Apr; 32:130-138.
    View in: PubMed
    Score: 0.203
  28. Neurturin-deficient mice develop dry eye and keratoconjunctivitis sicca. Invest Ophthalmol Vis Sci. 2003 Oct; 44(10):4223-9.
    View in: PubMed
    Score: 0.198
  29. Dry eye disease and blinking behaviors: A narrative review of methodologies for measuring blink dynamics and inducing blink response. Ocul Surf. 2023 Jul; 29:166-174.
    View in: PubMed
    Score: 0.193
  30. Non-invasive and objective tear film breakup detection on interference color images using convolutional neural networks. PLoS One. 2023; 18(3):e0282973.
    View in: PubMed
    Score: 0.190
  31. Anti-Inflammatories in the Treatment of Dry Eye Disease: A Review. J Ocul Pharmacol Ther. 2023 03; 39(2):89-101.
    View in: PubMed
    Score: 0.190
  32. Nicotinic acetylcholine receptor stimulation: A new approach for stimulating tear secretion in dry eye disease. Ocul Surf. 2022 07; 25:58-64.
    View in: PubMed
    Score: 0.180
  33. Dry eye and delayed tear clearance: "a call to arms.". Adv Exp Med Biol. 2002; 506(Pt B):739-43.
    View in: PubMed
    Score: 0.175
  34. Pro- and anti-inflammatory forms of interleukin-1 in the tear fluid and conjunctiva of patients with dry-eye disease. Invest Ophthalmol Vis Sci. 2001 Sep; 42(10):2283-92.
    View in: PubMed
    Score: 0.171
  35. Video Viewing Blink Rate in Normal and Dry Eyes. Eye Contact Lens. 2021 08 01; 47(8):442-444.
    View in: PubMed
    Score: 0.170
  36. Effects of laser in situ keratomileusis on tear production, clearance, and the ocular surface. Ophthalmology. 2001 Jul; 108(7):1230-5.
    View in: PubMed
    Score: 0.169
  37. Correlation of the Schirmer 1 and fluorescein clearance tests with the severity of corneal epithelial and eyelid disease. Arch Ophthalmol. 2000 Dec; 118(12):1632-8.
    View in: PubMed
    Score: 0.163
  38. The effects of experimental tear film removal on corneal surface regularity and barrier function. Ophthalmology. 2000 Sep; 107(9):1754-60.
    View in: PubMed
    Score: 0.160
  39. A standardized visual scale for evaluation of tear fluorescein clearance. Ophthalmology. 2000 Jul; 107(7):1338-43.
    View in: PubMed
    Score: 0.158
  40. Regulation of MMP-9 activity in human tear fluid and corneal epithelial culture supernatant. Invest Ophthalmol Vis Sci. 2000 Jun; 41(7):1703-9.
    View in: PubMed
    Score: 0.157
  41. Detection of sialomucin complex (MUC4) in human ocular surface epithelium and tear fluid. Invest Ophthalmol Vis Sci. 2000 May; 41(6):1316-26.
    View in: PubMed
    Score: 0.156
  42. Immune - Goblet cell interaction in the conjunctiva. Ocul Surf. 2020 04; 18(2):326-334.
    View in: PubMed
    Score: 0.153
  43. Tear fluid gelatinase B activity correlates with IL-1alpha concentration and fluorescein clearance in ocular rosacea. Invest Ophthalmol Vis Sci. 1999 Oct; 40(11):2506-12.
    View in: PubMed
    Score: 0.150
  44. Altered cytokine balance in the tear fluid and conjunctiva of patients with Sj?gren's syndrome keratoconjunctivitis sicca. Curr Eye Res. 1999 Sep; 19(3):201-11.
    View in: PubMed
    Score: 0.149
  45. Correlation of tear fluorescein clearance and Schirmer test scores with ocular irritation symptoms. Ophthalmology. 1999 Apr; 106(4):803-10.
    View in: PubMed
    Score: 0.145
  46. Evaluation of subjective assessments and objective diagnostic tests for diagnosing tear-film disorders known to cause ocular irritation. Cornea. 1998 Jan; 17(1):38-56.
    View in: PubMed
    Score: 0.133
  47. Cytokines and tear function in ocular surface disease. Adv Exp Med Biol. 1998; 438:461-9.
    View in: PubMed
    Score: 0.133
  48. Tear fluid influence on the ocular surface. Adv Exp Med Biol. 1998; 438:611-7.
    View in: PubMed
    Score: 0.133
  49. A unified theory of the role of the ocular surface in dry eye. Adv Exp Med Biol. 1998; 438:643-51.
    View in: PubMed
    Score: 0.133
  50. Study design and baseline findings from the progression of ocular findings (PROOF) natural history study of dry eye. BMC Ophthalmol. 2017 Dec 28; 17(1):265.
    View in: PubMed
    Score: 0.133
  51. Inflammatory cytokines in the tears of patients with ocular rosacea. Ophthalmology. 1997 Nov; 104(11):1868-74.
    View in: PubMed
    Score: 0.131
  52. Nasolacrimal stimulation of aqueous tear production. Cornea. 1997 Nov; 16(6):645-8.
    View in: PubMed
    Score: 0.131
  53. The Pathophysiology of Dry Eye Disease: What We Know and Future Directions for Research. Ophthalmology. 2017 11; 124(11S):S4-S13.
    View in: PubMed
    Score: 0.131
  54. The effects of age, gender, and fluid dynamics on the concentration of tear film epidermal growth factor. Cornea. 1997 Jul; 16(4):430-8.
    View in: PubMed
    Score: 0.128
  55. A novel method of tear collection: comparison of glass capillary micropipettes with porous polyester rods. Cornea. 1997 Jul; 16(4):450-8.
    View in: PubMed
    Score: 0.128
  56. Anterior Segment Optical Coherence Tomography (AS-OCT) in the Management of Dry Eye. Int Ophthalmol Clin. 2017; 57(2):13-22.
    View in: PubMed
    Score: 0.124
  57. Transforming growth factor beta-1 and beta-2 in human tear fluid. Curr Eye Res. 1996 Jun; 15(6):605-14.
    View in: PubMed
    Score: 0.119
  58. Differential diagnosis of dry eye conditions. Adv Dent Res. 1996 Apr; 10(1):9-12.
    View in: PubMed
    Score: 0.118
  59. Aqueous tear production in patients with neurotrophic keratitis. Cornea. 1996 Mar; 15(2):135-8.
    View in: PubMed
    Score: 0.117
  60. Effects of azithromycin on gene expression profiles of proinflammatory and anti-inflammatory mediators in the eyelid margin and conjunctiva of patients with meibomian gland disease. JAMA Ophthalmol. 2015 Oct; 133(10):1117-23.
    View in: PubMed
    Score: 0.114
  61. Substrate modulation of morphology, growth, and tear protein production by cultured human lacrimal gland epithelial cells. Exp Cell Res. 1995 Sep; 220(1):138-51.
    View in: PubMed
    Score: 0.113
  62. Effects of Dry Eye Therapies on Environmentally Induced Ocular Surface Disease. Am J Ophthalmol. 2015 Jul; 160(1):135-42.e1.
    View in: PubMed
    Score: 0.110
  63. Altered balance of interleukin-13/interferon-gamma contributes to lacrimal gland destruction and secretory dysfunction in CD25 knockout model of Sj?gren's syndrome. Arthritis Res Ther. 2015 Mar 10; 17:53.
    View in: PubMed
    Score: 0.109
  64. Clinical guidelines for management of dry eye associated with Sj?gren disease. Ocul Surf. 2015 Apr; 13(2):118-32.
    View in: PubMed
    Score: 0.108
  65. Factors predicting the ocular surface response to desiccating environmental stress. Invest Ophthalmol Vis Sci. 2013 May 07; 54(5):3325-32.
    View in: PubMed
    Score: 0.096
  66. Dry eye as a mucosal autoimmune disease. Int Rev Immunol. 2013 Feb; 32(1):19-41.
    View in: PubMed
    Score: 0.095
  67. Pharmacological cholinergic blockade stimulates inflammatory cytokine production and lymphocytic infiltration in the mouse lacrimal gland. Invest Ophthalmol Vis Sci. 2011 May 16; 52(6):3221-7.
    View in: PubMed
    Score: 0.084
  68. Anterior segment optical coherence tomography: a diagnostic instrument for conjunctivochalasis. Am J Ophthalmol. 2010 Dec; 150(6):798-806.
    View in: PubMed
    Score: 0.081
  69. Multicenter open-label study evaluating the efficacy of azithromycin ophthalmic solution 1% on the signs and symptoms of subjects with blepharitis. Cornea. 2010 Aug; 29(8):871-7.
    View in: PubMed
    Score: 0.079
  70. Amplification of Epstein-Barr virus genomic sequences in blood cells, lacrimal glands, and tears from primary Sj?gren's syndrome patients. Ophthalmology. 1990 Aug; 97(8):976-84.
    View in: PubMed
    Score: 0.079
  71. Altered morphology and function of the lacrimal functional unit in protein kinase C{alpha} knockout mice. Invest Ophthalmol Vis Sci. 2010 Nov; 51(11):5592-600.
    View in: PubMed
    Score: 0.078
  72. Epstein-Barr virus infection and immunologic dysfunction in patients with aqueous tear deficiency. Ophthalmology. 1990 Mar; 97(3):313-23.
    View in: PubMed
    Score: 0.077
  73. Age-related T-cell cytokine profile parallels corneal disease severity in Sjogren's syndrome-like keratoconjunctivitis sicca in CD25KO mice. Rheumatology (Oxford). 2010 Feb; 49(2):246-58.
    View in: PubMed
    Score: 0.076
  74. Corneal epithelial opacity in dysfunctional tear syndrome. Am J Ophthalmol. 2009 Sep; 148(3):376-82.
    View in: PubMed
    Score: 0.074
  75. Interleukin-1 receptor-1-deficient mice show attenuated production of ocular surface inflammatory cytokines in experimental dry eye. Cornea. 2008 Aug; 27(7):811-7.
    View in: PubMed
    Score: 0.069
  76. Dry eye-induced conjunctival epithelial squamous metaplasia is modulated by interferon-gamma. Invest Ophthalmol Vis Sci. 2007 Jun; 48(6):2553-60.
    View in: PubMed
    Score: 0.064
  77. Dysfunctional tear syndrome: a Delphi approach to treatment recommendations. Cornea. 2006 Sep; 25(8):900-7.
    View in: PubMed
    Score: 0.061
  78. Destructive and protective effects and therapeutic targets of IL-36 family cytokines in dry eye disease. Ocul Surf. 2025 Apr; 36:83-93.
    View in: PubMed
    Score: 0.054
  79. Experimental dry eye stimulates production of inflammatory cytokines and MMP-9 and activates MAPK signaling pathways on the ocular surface. Invest Ophthalmol Vis Sci. 2004 Dec; 45(12):4293-301.
    View in: PubMed
    Score: 0.054
  80. Hormonal deficiencies and dry eye. Arch Ophthalmol. 2004 Feb; 122(2):273-4.
    View in: PubMed
    Score: 0.051
  81. Assessing the severity of keratitis sicca with videokeratoscopic indices. Ophthalmology. 2003 Jun; 110(6):1102-9.
    View in: PubMed
    Score: 0.048
  82. Keratoconus-like topographic changes in keratoconjunctivitis sicca. Cornea. 2003 Jan; 22(1):22-4.
    View in: PubMed
    Score: 0.047
  83. Gut-derived butyrate suppresses ocular surface inflammation. Sci Rep. 2022 03 16; 12(1):4512.
    View in: PubMed
    Score: 0.044
  84. A mouse model of keratoconjunctivitis sicca. Invest Ophthalmol Vis Sci. 2002 Mar; 43(3):632-8.
    View in: PubMed
    Score: 0.044
  85. Experimentally induced dry eye produces ocular surface inflammation and epithelial disease. Adv Exp Med Biol. 2002; 506(Pt A):647-55.
    View in: PubMed
    Score: 0.044
  86. Dry eye disease flares: A rapid evidence assessment. Ocul Surf. 2021 10; 22:51-59.
    View in: PubMed
    Score: 0.042
  87. The effect of punctal occlusion on tear production, tear clearance, and ocular surface sensation in normal subjects. Am J Ophthalmol. 2001 Mar; 131(3):314-23.
    View in: PubMed
    Score: 0.041
  88. Defining Dry Eye from a Clinical Perspective. Int J Mol Sci. 2020 Dec 04; 21(23).
    View in: PubMed
    Score: 0.041
  89. Rapamycin Eyedrops Increased CD4+Foxp3+ Cells and Prevented Goblet Cell Loss in the Aged Ocular Surface. Int J Mol Sci. 2020 Nov 24; 21(23).
    View in: PubMed
    Score: 0.041
  90. The diagnosis and management of dry eye: a twenty-five-year review. Cornea. 2000 Sep; 19(5):644-9.
    View in: PubMed
    Score: 0.040
  91. Corneal surface regularity and the effect of artificial tears in aqueous tear deficiency. Ophthalmology. 1999 May; 106(5):939-43.
    View in: PubMed
    Score: 0.036
  92. Topical nonpreserved methylprednisolone therapy for keratoconjunctivitis sicca in Sj?gren syndrome. Ophthalmology. 1999 Apr; 106(4):811-6.
    View in: PubMed
    Score: 0.036
  93. Correlation of goblet cell density and mucosal epithelial membrane mucin expression with rose bengal staining in patients with ocular irritation. Ophthalmology. 1997 Feb; 104(2):223-35.
    View in: PubMed
    Score: 0.031
  94. Clusterin Seals the Ocular Surface Barrier in Mouse Dry Eye. PLoS One. 2015; 10(9):e0138958.
    View in: PubMed
    Score: 0.028
  95. Long-term Supplementation With n-6 and n-3 PUFAs Improves Moderate-to-Severe Keratoconjunctivitis Sicca: A Randomized Double-Blind Clinical Trial. Cornea. 2013 Oct; 32(10):1297-304.
    View in: PubMed
    Score: 0.025
  96. Deletion of interferon-? delays onset and severity of dacryoadenitis in CD25KO mice. Arthritis Res Ther. 2012 Nov 01; 14(6):R234.
    View in: PubMed
    Score: 0.023
  97. Phase III safety evaluation of cyclosporine 0.1% ophthalmic emulsion administered twice daily to dry eye disease patients for up to 3 years. Ophthalmology. 2005 Oct; 112(10):1790-4.
    View in: PubMed
    Score: 0.014
Connection Strength

The connection strength for concepts is the sum of the scores for each matching publication.

Publication scores are based on many factors, including how long ago they were written and whether the person is a first or senior author.