STEPHEN PFLUGFELDER to Dry Eye Syndromes
This is a "connection" page, showing publications STEPHEN PFLUGFELDER has written about Dry Eye Syndromes.
Connection Strength
31.726
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Changes in conjunctival mononuclear phagocytes and suppressive activity of regulatory macrophages in desiccation induced dry eye. Ocul Surf. 2024 Oct; 34:348-362.
Score: 0.701
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Dry eye disease and blinking behaviors: A narrative review of methodologies for measuring blink dynamics and inducing blink response. Ocul Surf. 2023 Jul; 29:166-174.
Score: 0.640
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Induction of Innate Inflammatory Pathways in the Corneal Epithelium in the Desiccating Stress Dry Eye Model. Invest Ophthalmol Vis Sci. 2023 04 03; 64(4):8.
Score: 0.633
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Non-invasive and objective tear film breakup detection on interference color images using convolutional neural networks. PLoS One. 2023; 18(3):e0282973.
Score: 0.631
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Anti-Inflammatories in the Treatment of Dry Eye Disease: A Review. J Ocul Pharmacol Ther. 2023 03; 39(2):89-101.
Score: 0.628
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Quantitative assessment of botulinum toxin injection on blink rate in blepharospasm. Orbit. 2023 Dec; 42(6):571-578.
Score: 0.619
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Non-Invasive Tear Break-Up Detection with the Kowa DR-1a and Its Relationship to Dry Eye Clinical Severity. Int J Mol Sci. 2022 Nov 25; 23(23).
Score: 0.618
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Nicotinic acetylcholine receptor stimulation: A new approach for stimulating tear secretion in dry eye disease. Ocul Surf. 2022 07; 25:58-64.
Score: 0.595
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Combined therapy of ocular surface disease with plasma rich in growth factors and scleral contact lenses. Ocul Surf. 2022 01; 23:162-168.
Score: 0.569
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Video Viewing Blink Rate in Normal and Dry Eyes. Eye Contact Lens. 2021 08 01; 47(8):442-444.
Score: 0.564
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Conjunctivochalasis and Tear Osmolarity Are Associated With Reduced Conjunctival Epithelial Thickness in Dry Eye. Am J Ophthalmol. 2021 07; 227:35-44.
Score: 0.546
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Inflammatory basis for dry eye disease flares. Exp Eye Res. 2020 12; 201:108294.
Score: 0.533
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Calcineurin Inhibitor Voclosporin Preserves Corneal Barrier and Conjunctival Goblet Cells in Experimental Dry Eye. J Ocul Pharmacol Ther. 2020 11; 36(9):679-685.
Score: 0.525
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Biological functions of tear film. Exp Eye Res. 2020 08; 197:108115.
Score: 0.522
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Regional Comparison of Goblet Cell Number and Area in Exposed and Covered Dry Eyes and Their Correlation with Tear MUC5AC. Sci Rep. 2020 02 19; 10(1):2933.
Score: 0.510
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Immune - Goblet cell interaction in the conjunctiva. Ocul Surf. 2020 04; 18(2):326-334.
Score: 0.507
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Goblet cell loss abrogates ocular surface immune tolerance. JCI Insight. 2018 02 08; 3(3).
Score: 0.443
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The Pathophysiology of Dry Eye Disease: What We Know and Future Directions for Research. Ophthalmology. 2017 11; 124(11S):S4-S13.
Score: 0.435
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Goblet Cells Contribute to Ocular Surface Immune Tolerance-Implications for Dry Eye Disease. Int J Mol Sci. 2017 May 05; 18(5).
Score: 0.420
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Randomized Controlled Crossover Trial Comparing the Impact of Sham or Intranasal Tear Neurostimulation on Conjunctival Goblet Cell Degranulation. Am J Ophthalmol. 2017 May; 177:159-168.
Score: 0.416
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Intranasal Tear Neurostimulation: An Emerging Concept in the Treatment of Dry Eye. Int Ophthalmol Clin. 2017; 57(2):101-108.
Score: 0.411
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What We Have Learned From Animal Models of Dry Eye. Int Ophthalmol Clin. 2017; 57(2):109-118.
Score: 0.411
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LFA-1/ICAM-1 Interaction as a Therapeutic Target in Dry Eye Disease. J Ocul Pharmacol Ther. 2017 Jan/Feb; 33(1):5-12.
Score: 0.408
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Aqueous Tear Deficiency Increases Conjunctival Interferon-? (IFN-?) Expression and Goblet Cell Loss. Invest Ophthalmol Vis Sci. 2015 Nov; 56(12):7545-50.
Score: 0.379
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Corneal Sensitivity in Tear Dysfunction and its Correlation With Clinical Parameters and Blink Rate. Am J Ophthalmol. 2015 Nov; 160(5):858-866.e5.
Score: 0.372
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IL-13 Stimulates Proliferation and Expression of Mucin and Immunomodulatory Genes in Cultured Conjunctival Goblet Cells. Invest Ophthalmol Vis Sci. 2015 Jul; 56(8):4186-97.
Score: 0.370
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Effects of Dry Eye Therapies on Environmentally Induced Ocular Surface Disease. Am J Ophthalmol. 2015 Jul; 160(1):135-42.e1.
Score: 0.364
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Macrophage Phenotype in the Ocular Surface of Experimental Murine Dry Eye Disease. Arch Immunol Ther Exp (Warsz). 2015 Aug; 63(4):299-304.
Score: 0.362
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Mucosal environmental sensors in the pathogenesis of dry eye. Expert Rev Clin Immunol. 2014 Sep; 10(9):1137-40.
Score: 0.347
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New testing options for diagnosing and grading dry eye disease. Am J Ophthalmol. 2014 Jun; 157(6):1122-9.
Score: 0.338
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What causes dryness in Sj?gren's syndrome patients and how can it be targeted? Expert Rev Clin Immunol. 2014 Apr; 10(4):425-7.
Score: 0.337
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Topical interferon-gamma neutralization prevents conjunctival goblet cell loss in experimental murine dry eye. Exp Eye Res. 2014 Jan; 118:117-24.
Score: 0.332
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Tear meniscus dimensions in tear dysfunction and their correlation with clinical parameters. Am J Ophthalmol. 2014 Feb; 157(2):301-310.e1.
Score: 0.327
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T helper cytokines in dry eye disease. Exp Eye Res. 2013 Dec; 117:118-25.
Score: 0.326
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Factors predicting the ocular surface response to desiccating environmental stress. Invest Ophthalmol Vis Sci. 2013 May 07; 54(5):3325-32.
Score: 0.319
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Dry eye as a mucosal autoimmune disease. Int Rev Immunol. 2013 Feb; 32(1):19-41.
Score: 0.313
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Autoantibodies contribute to the immunopathogenesis of experimental dry eye disease. Invest Ophthalmol Vis Sci. 2012 Apr 24; 53(4):2062-75.
Score: 0.297
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Interferon-? exacerbates dry eye-induced apoptosis in conjunctiva through dual apoptotic pathways. Invest Ophthalmol Vis Sci. 2011 Aug 09; 52(9):6279-85.
Score: 0.282
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Entrapment of conjunctival goblet cells by desiccation-induced cornification. Invest Ophthalmol Vis Sci. 2011 Jun 01; 52(6):3492-9.
Score: 0.279
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Evaluation of the transforming growth factor-beta activity in normal and dry eye human tears by CCL-185 cell bioassay. Cornea. 2010 Sep; 29(9):1048-54.
Score: 0.265
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Post-LASIK tear dysfunction and dysesthesia. Ocul Surf. 2010 Jul; 8(3):135-45.
Score: 0.262
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Altered morphology and function of the lacrimal functional unit in protein kinase C{alpha} knockout mice. Invest Ophthalmol Vis Sci. 2010 Nov; 51(11):5592-600.
Score: 0.260
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Desiccating stress promotion of Th17 differentiation by ocular surface tissues through a dendritic cell-mediated pathway. Invest Ophthalmol Vis Sci. 2010 Jun; 51(6):3083-91.
Score: 0.254
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Minimal clinically important difference for the ocular surface disease index. Arch Ophthalmol. 2010 Jan; 128(1):94-101.
Score: 0.253
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Essential role for c-Jun N-terminal kinase 2 in corneal epithelial response to desiccating stress. Arch Ophthalmol. 2009 Dec; 127(12):1625-31.
Score: 0.251
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Association between high tear epidermal growth factor levels and corneal subepithelial fibrosis in dry eye conditions. Invest Ophthalmol Vis Sci. 2010 Feb; 51(2):844-9.
Score: 0.249
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Corneal epithelial opacity in dysfunctional tear syndrome. Am J Ophthalmol. 2009 Sep; 148(3):376-82.
Score: 0.244
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Production and activity of matrix metalloproteinase-9 on the ocular surface increase in dysfunctional tear syndrome. Invest Ophthalmol Vis Sci. 2009 Jul; 50(7):3203-9.
Score: 0.238
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IL-17 disrupts corneal barrier following desiccating stress. Mucosal Immunol. 2009 May; 2(3):243-53.
Score: 0.238
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Tear cytokine profiles in dysfunctional tear syndrome. Am J Ophthalmol. 2009 Feb; 147(2):198-205. e1.
Score: 0.233
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Rationale for anti-inflammatory therapy in dry eye syndrome. Arq Bras Oftalmol. 2008 Nov-Dec; 71(6 Suppl):89-95.
Score: 0.233
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Desiccating stress decreases apical corneal epithelial cell size--modulation by the metalloproteinase inhibitor doxycycline. Cornea. 2008 Sep; 27(8):935-40.
Score: 0.230
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Epithelial-immune cell interaction in dry eye. Cornea. 2008 Sep; 27 Suppl 1:S9-11.
Score: 0.230
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Interleukin-1 receptor-1-deficient mice show attenuated production of ocular surface inflammatory cytokines in experimental dry eye. Cornea. 2008 Aug; 27(7):811-7.
Score: 0.229
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Prevalence, burden, and pharmacoeconomics of dry eye disease. Am J Manag Care. 2008 Apr; 14(3 Suppl):S102-6.
Score: 0.224
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Effects of sequential artificial tear and cyclosporine emulsion therapy on conjunctival goblet cell density and transforming growth factor-beta2 production. Cornea. 2008 Jan; 27(1):64-9.
Score: 0.220
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Future directions in therapeutic interventions for conjunctival inflammatory disorders. Curr Opin Allergy Clin Immunol. 2007 Oct; 7(5):450-3.
Score: 0.216
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Dry eye-induced conjunctival epithelial squamous metaplasia is modulated by interferon-gamma. Invest Ophthalmol Vis Sci. 2007 Jun; 48(6):2553-60.
Score: 0.211
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Expression of Th-1 chemokines and chemokine receptors on the ocular surface of C57BL/6 mice: effects of desiccating stress. Invest Ophthalmol Vis Sci. 2007 Jun; 48(6):2561-9.
Score: 0.211
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Strain-related cytokine profiles on the murine ocular surface in response to desiccating stress. Cornea. 2007 Jun; 26(5):579-84.
Score: 0.211
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Desiccating stress stimulates expression of matrix metalloproteinases by the corneal epithelium. Invest Ophthalmol Vis Sci. 2006 Aug; 47(8):3293-302.
Score: 0.199
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Apical corneal barrier disruption in experimental murine dry eye is abrogated by methylprednisolone and doxycycline. Invest Ophthalmol Vis Sci. 2006 Jul; 47(7):2847-56.
Score: 0.198
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Corticosteroid and doxycycline suppress MMP-9 and inflammatory cytokine expression, MAPK activation in the corneal epithelium in experimental dry eye. Exp Eye Res. 2006 Sep; 83(3):526-35.
Score: 0.196
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The incidence and risk factors for developing dry eye after myopic LASIK. Am J Ophthalmol. 2006 Mar; 141(3):438-45.
Score: 0.194
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Integrating restasis into the management of dry eye. Int Ophthalmol Clin. 2006; 46(4):101-3.
Score: 0.192
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Effect of experimental dry eye on tear sodium concentration in the mouse. Eye Contact Lens. 2005 Jul; 31(4):175-8.
Score: 0.185
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Identification of a translatable animal model for dry eye disease using comparative analysis of tear proteins across species. Ocul Surf. 2025 Jul; 37:260-272.
Score: 0.183
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Destructive and protective effects and therapeutic targets of IL-36 family cytokines in dry eye disease. Ocul Surf. 2025 Apr; 36:83-93.
Score: 0.179
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Matrix metalloproteinase-9 knockout confers resistance to corneal epithelial barrier disruption in experimental dry eye. Am J Pathol. 2005 Jan; 166(1):61-71.
Score: 0.179
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Experimental dry eye stimulates production of inflammatory cytokines and MMP-9 and activates MAPK signaling pathways on the ocular surface. Invest Ophthalmol Vis Sci. 2004 Dec; 45(12):4293-301.
Score: 0.178
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Ectoine Enhances Mucin Production Via Restoring IL-13/IFN-? Balance in a Murine Dry Eye Model. Invest Ophthalmol Vis Sci. 2024 Jun 03; 65(6):39.
Score: 0.172
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Tear clearance implications for ocular surface health. Exp Eye Res. 2004 Mar; 78(3):395-7.
Score: 0.169
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The role of the lacrimal functional unit in the pathophysiology of dry eye. Exp Eye Res. 2004 Mar; 78(3):409-16.
Score: 0.169
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Hormonal deficiencies and dry eye. Arch Ophthalmol. 2004 Feb; 122(2):273-4.
Score: 0.168
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Antiinflammatory therapy for dry eye. Am J Ophthalmol. 2004 Feb; 137(2):337-42.
Score: 0.168
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Corneal epitheliopathy of dry eye induces hyperesthesia to mechanical air jet stimulation. Am J Ophthalmol. 2004 Jan; 137(1):109-15.
Score: 0.167
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Differentially Expressed Tear Proteins in Sj?gren's Syndrome Keratoconjunctivitis Sicca. Transl Vis Sci Technol. 2023 06 01; 12(6):8.
Score: 0.160
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Apoptosis of ocular surface cells in experimentally induced dry eye. Invest Ophthalmol Vis Sci. 2003 Jan; 44(1):124-9.
Score: 0.156
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Imbalanced IL-37/TNF-a/CTSS signaling disrupts corneal epithelial barrier in a dry eye model in vitro. Ocul Surf. 2022 10; 26:234-243.
Score: 0.153
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Multicenter prospective validation study for international chronic ocular graft-versus-host disease consensus diagnostic criteria. Ocul Surf. 2022 10; 26:200-208.
Score: 0.152
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A multicenter report of the use of plasma rich in growth factors (PRGF) for the treatment of patients with ocular surface diseases in North America. Ocul Surf. 2022 07; 25:40-48.
Score: 0.148
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Experimentally induced dry eye produces ocular surface inflammation and epithelial disease. Adv Exp Med Biol. 2002; 506(Pt A):647-55.
Score: 0.145
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Dry eye and delayed tear clearance: "a call to arms.". Adv Exp Med Biol. 2002; 506(Pt B):739-43.
Score: 0.145
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Pro- and anti-inflammatory forms of interleukin-1 in the tear fluid and conjunctiva of patients with dry-eye disease. Invest Ophthalmol Vis Sci. 2001 Sep; 42(10):2283-92.
Score: 0.142
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IL-36a/IL-36RA/IL-38 signaling mediates inflammation and barrier disruption in human corneal epithelial cells under hyperosmotic stress. Ocul Surf. 2021 10; 22:163-171.
Score: 0.142
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Dry eye disease flares: A rapid evidence assessment. Ocul Surf. 2021 10; 22:51-59.
Score: 0.141
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Desiccation Induced Conjunctival Monocyte Recruitment and Activation - Implications for Keratoconjunctivitis. Front Immunol. 2021; 12:701415.
Score: 0.140
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Effects of laser in situ keratomileusis on tear production, clearance, and the ocular surface. Ophthalmology. 2001 Jul; 108(7):1230-5.
Score: 0.140
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Retinoid Regulation of Ocular Surface Innate Inflammation. Int J Mol Sci. 2021 Jan 22; 22(3).
Score: 0.136
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Defining Dry Eye from a Clinical Perspective. Int J Mol Sci. 2020 Dec 04; 21(23).
Score: 0.135
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Autophagy Activation Protects Ocular Surface from Inflammation in a Dry Eye Model In Vitro. Int J Mol Sci. 2020 Nov 26; 21(23).
Score: 0.134
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Rapamycin Eyedrops Increased CD4+Foxp3+ Cells and Prevented Goblet Cell Loss in the Aged Ocular Surface. Int J Mol Sci. 2020 Nov 24; 21(23).
Score: 0.134
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The diagnosis and management of dry eye: a twenty-five-year review. Cornea. 2000 Sep; 19(5):644-9.
Score: 0.132
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A standardized visual scale for evaluation of tear fluorescein clearance. Ophthalmology. 2000 Jul; 107(7):1338-43.
Score: 0.131
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[The effect of artificial tears on corneal surface regularity in dry eye]. Zhonghua Yan Ke Za Zhi. 2000 Mar; 36(2):131-4.
Score: 0.128
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Topical cyclosporine A therapy for dry eye syndrome. Cochrane Database Syst Rev. 2019 09 13; 9:CD010051.
Score: 0.124
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Corneal thickness is reduced in dry eye. Cornea. 1999 Jul; 18(4):403-7.
Score: 0.122
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Corneal surface regularity and the effect of artificial tears in aqueous tear deficiency. Ophthalmology. 1999 May; 106(5):939-43.
Score: 0.121
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Correlation of tear fluorescein clearance and Schirmer test scores with ocular irritation symptoms. Ophthalmology. 1999 Apr; 106(4):803-10.
Score: 0.120
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Age-associated antigen-presenting cell alterations promote dry-eye inducing Th1 cells. Mucosal Immunol. 2019 07; 12(4):897-908.
Score: 0.119
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The pathology of dry eye: the interaction between the ocular surface and lacrimal glands. Cornea. 1998 Nov; 17(6):584-9.
Score: 0.117
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Reduced intraepithelial corneal nerve density and sensitivity accompany desiccating stress and aging in C57BL/6 mice. Exp Eye Res. 2018 04; 169:91-98.
Score: 0.111
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Evaluation of subjective assessments and objective diagnostic tests for diagnosing tear-film disorders known to cause ocular irritation. Cornea. 1998 Jan; 17(1):38-56.
Score: 0.110
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A unified theory of the role of the ocular surface in dry eye. Adv Exp Med Biol. 1998; 438:643-51.
Score: 0.110
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Study design and baseline findings from the progression of ocular findings (PROOF) natural history study of dry eye. BMC Ophthalmol. 2017 Dec 28; 17(1):265.
Score: 0.110
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Mitochondrial DNA oxidation induces imbalanced activity of NLRP3/NLRP6 inflammasomes by activation of caspase-8 and BRCC36 in dry eye. J Autoimmun. 2017 Jun; 80:65-76.
Score: 0.104
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Tear Volume-based Diagnostic Classification for Tear Dysfunction. Int Ophthalmol Clin. 2017; 57(2):1-12.
Score: 0.103
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Interferon-gamma deficiency protects against aging-related goblet cell loss. Oncotarget. 2016 10 04; 7(40):64605-64614.
Score: 0.101
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Dexamethasone Drug Eluting Nanowafers Control Inflammation in Alkali-Burned Corneas Associated With Dry Eye. Invest Ophthalmol Vis Sci. 2016 06 01; 57(7):3222-30.
Score: 0.099
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Inflammatory Response to Lipopolysaccharide on the Ocular Surface in a Murine Dry Eye Model. Invest Ophthalmol Vis Sci. 2016 05 01; 57(6):2443-51.
Score: 0.098
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Altered Mucosal Microbiome Diversity and Disease Severity in Sj?gren Syndrome. Sci Rep. 2016 Apr 18; 6:23561.
Score: 0.098
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Differential diagnosis of dry eye conditions. Adv Dent Res. 1996 Apr; 10(1):9-12.
Score: 0.097
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MMP-8 Is Critical for Dexamethasone Therapy in Alkali-Burned Corneas Under Dry Eye Conditions. J Cell Physiol. 2016 11; 231(11):2506-16.
Score: 0.097
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Lifitegrast, a Novel Integrin Antagonist for Treatment of Dry Eye Disease. Ocul Surf. 2016 04; 14(2):207-15.
Score: 0.096
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Clusterin Seals the Ocular Surface Barrier in Mouse Dry Eye. PLoS One. 2015; 10(9):e0138958.
Score: 0.094
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Improvement of Outcome Measures of Dry Eye by a Novel Integrin Antagonist in the Murine Desiccating Stress Model. Invest Ophthalmol Vis Sci. 2015 Sep; 56(10):5888-95.
Score: 0.094
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Dexamethasone nanowafer as an effective therapy for dry eye disease. J Control Release. 2015 Sep 10; 213:168-174.
Score: 0.093
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Clinical guidelines for management of dry eye associated with Sj?gren disease. Ocul Surf. 2015 Apr; 13(2):118-32.
Score: 0.090
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Effect of loteprednol etabonate 0.5% on initiation of dry eye treatment with topical cyclosporine 0.05%. Eye Contact Lens. 2014 Sep; 40(5):289-96.
Score: 0.087
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Ocular surface disease and dacryoadenitis in aging C57BL/6 mice. Am J Pathol. 2014 Mar; 184(3):631-43.
Score: 0.083
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In vivo confocal microscopy of the ocular surface: from bench to bedside. Curr Eye Res. 2014 Mar; 39(3):213-31.
Score: 0.083
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Effect of desiccating stress on mouse meibomian gland function. Ocul Surf. 2014 Jan; 12(1):59-68.
Score: 0.082
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Dendritic cell-derived thrombospondin-1 is critical for the generation of the ocular surface Th17 response to desiccating stress. J Leukoc Biol. 2013 Dec; 94(6):1293-301.
Score: 0.081
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Morphologic alterations of the palpebral conjunctival epithelium in a dry eye model. Cornea. 2013 Apr; 32(4):483-90.
Score: 0.079
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Toll-like receptor expression and activation in mice with experimental dry eye. Invest Ophthalmol Vis Sci. 2013 Feb 28; 54(2):1554-63.
Score: 0.079
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Resolvin E1 (RX-10001) reduces corneal epithelial barrier disruption and protects against goblet cell loss in a murine model of dry eye. Cornea. 2012 Nov; 31(11):1299-303.
Score: 0.077
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NK cells promote Th-17 mediated corneal barrier disruption in dry eye. PLoS One. 2012; 7(5):e36822.
Score: 0.074
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Disruption of TGF-? signaling improves ocular surface epithelial disease in experimental autoimmune keratoconjunctivitis sicca. PLoS One. 2011; 6(12):e29017.
Score: 0.072
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Low humidity environmental challenge causes barrier disruption and cornification of the mouse corneal epithelium via a c-jun N-terminal kinase 2 (JNK2) pathway. Exp Eye Res. 2012 Jan; 94(1):150-6.
Score: 0.072
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Dysfunctional tear syndrome: a Delphi approach to treatment recommendations. Cornea. 2006 Sep; 25(8):900-7.
Score: 0.050
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Phase III safety evaluation of cyclosporine 0.1% ophthalmic emulsion administered twice daily to dry eye disease patients for up to 3 years. Ophthalmology. 2005 Oct; 112(10):1790-4.
Score: 0.047
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Interleukin-6 levels in the conjunctival epithelium of patients with dry eye disease treated with cyclosporine ophthalmic emulsion. Cornea. 2000 Jul; 19(4):492-6.
Score: 0.033
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The gut-eye-lacrimal gland-microbiome axis in Sj?gren Syndrome. Ocul Surf. 2020 04; 18(2):335-344.
Score: 0.031
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Suppression of Th1-Mediated Keratoconjunctivitis Sicca by Lifitegrast. J Ocul Pharmacol Ther. 2018 09; 34(7):543-549.
Score: 0.028
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Tear fluid influence on the ocular surface. Adv Exp Med Biol. 1998; 438:611-7.
Score: 0.027
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Differential Effects of Dexamethasone and Doxycycline on Inflammation and MMP Production in Murine Alkali-Burned Corneas Associated with Dry Eye. Ocul Surf. 2016 04; 14(2):242-54.
Score: 0.024
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In vitro expanded CD4+CD25+Foxp3+ regulatory T cells maintain a normal phenotype and suppress immune-mediated ocular surface inflammation. Invest Ophthalmol Vis Sci. 2008 Dec; 49(12):5434-40.
Score: 0.014