STEPHEN PFLUGFELDER to Animals
This is a "connection" page, showing publications STEPHEN PFLUGFELDER has written about Animals.
Connection Strength
1.545
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Induction of Innate Inflammatory Pathways in the Corneal Epithelium in the Desiccating Stress Dry Eye Model. Invest Ophthalmol Vis Sci. 2023 04 03; 64(4):8.
Score: 0.039
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Comparison of Efficacy and Inflammatory Response to Thermoconjunctivoplasty Performed with Cautery or Pulsed 1460 nm Laser. Int J Mol Sci. 2023 Mar 17; 24(6).
Score: 0.039
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Single-cell transcriptional profiling of murine conjunctival immune cells reveals distinct populations expressing homeostatic and regulatory genes. Mucosal Immunol. 2022 04; 15(4):620-628.
Score: 0.037
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Desiccation Induced Conjunctival Monocyte Recruitment and Activation - Implications for Keratoconjunctivitis. Front Immunol. 2021; 12:701415.
Score: 0.035
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Retinoid Regulation of Ocular Surface Innate Inflammation. Int J Mol Sci. 2021 Jan 22; 22(3).
Score: 0.034
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Calcineurin Inhibitor Voclosporin Preserves Corneal Barrier and Conjunctival Goblet Cells in Experimental Dry Eye. J Ocul Pharmacol Ther. 2020 11; 36(9):679-685.
Score: 0.033
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Immune - Goblet cell interaction in the conjunctiva. Ocul Surf. 2020 04; 18(2):326-334.
Score: 0.032
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Goblet cell-produced retinoic acid suppresses CD86 expression and IL-12 production in bone marrow-derived cells. Int Immunol. 2018 09 25; 30(10):457-470.
Score: 0.029
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Goblet cell loss abrogates ocular surface immune tolerance. JCI Insight. 2018 02 08; 3(3).
Score: 0.028
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Goblet Cells Contribute to Ocular Surface Immune Tolerance-Implications for Dry Eye Disease. Int J Mol Sci. 2017 May 05; 18(5).
Score: 0.026
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What We Have Learned From Animal Models of Dry Eye. Int Ophthalmol Clin. 2017; 57(2):109-118.
Score: 0.026
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LFA-1/ICAM-1 Interaction as a Therapeutic Target in Dry Eye Disease. J Ocul Pharmacol Ther. 2017 Jan/Feb; 33(1):5-12.
Score: 0.025
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Altered Mucosal Microbiome Diversity and Disease Severity in Sj?gren Syndrome. Sci Rep. 2016 Apr 18; 6:23561.
Score: 0.024
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Interferon-?-Induced Unfolded Protein Response in Conjunctival Goblet Cells as a Cause of Mucin Deficiency in Sj?gren Syndrome. Am J Pathol. 2016 06; 186(6):1547-58.
Score: 0.024
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IL-13 Stimulates Proliferation and Expression of Mucin and Immunomodulatory Genes in Cultured Conjunctival Goblet Cells. Invest Ophthalmol Vis Sci. 2015 Jul; 56(8):4186-97.
Score: 0.023
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Age-Related Conjunctival Disease in the C57BL/6.NOD-Aec1Aec2 Mouse Model of Sj?gren Syndrome Develops Independent of Lacrimal Dysfunction. Invest Ophthalmol Vis Sci. 2015 Apr; 56(4):2224-33.
Score: 0.023
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Macrophage Phenotype in the Ocular Surface of Experimental Murine Dry Eye Disease. Arch Immunol Ther Exp (Warsz). 2015 Aug; 63(4):299-304.
Score: 0.023
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Mucosal environmental sensors in the pathogenesis of dry eye. Expert Rev Clin Immunol. 2014 Sep; 10(9):1137-40.
Score: 0.022
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Topical interferon-gamma neutralization prevents conjunctival goblet cell loss in experimental murine dry eye. Exp Eye Res. 2014 Jan; 118:117-24.
Score: 0.021
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T helper cytokines in dry eye disease. Exp Eye Res. 2013 Dec; 117:118-25.
Score: 0.020
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Dry eye as a mucosal autoimmune disease. Int Rev Immunol. 2013 Feb; 32(1):19-41.
Score: 0.019
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Autoantibodies contribute to the immunopathogenesis of experimental dry eye disease. Invest Ophthalmol Vis Sci. 2012 Apr 24; 53(4):2062-75.
Score: 0.018
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Disruption of TGF-? signaling improves ocular surface epithelial disease in experimental autoimmune keratoconjunctivitis sicca. PLoS One. 2011; 6(12):e29017.
Score: 0.018
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Desiccating stress induces CD4+ T-cell-mediated Sj?gren's syndrome-like corneal epithelial apoptosis via activation of the extrinsic apoptotic pathway by interferon-?. Am J Pathol. 2011 Oct; 179(4):1807-14.
Score: 0.018
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Interferon-? exacerbates dry eye-induced apoptosis in conjunctiva through dual apoptotic pathways. Invest Ophthalmol Vis Sci. 2011 Aug 09; 52(9):6279-85.
Score: 0.018
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Entrapment of conjunctival goblet cells by desiccation-induced cornification. Invest Ophthalmol Vis Sci. 2011 Jun 01; 52(6):3492-9.
Score: 0.017
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Pharmacological cholinergic blockade stimulates inflammatory cytokine production and lymphocytic infiltration in the mouse lacrimal gland. Invest Ophthalmol Vis Sci. 2011 May 16; 52(6):3221-7.
Score: 0.017
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Homeostatic control of conjunctival mucosal goblet cells by NKT-derived IL-13. Mucosal Immunol. 2011 Jul; 4(4):397-408.
Score: 0.017
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Evaluation of the transforming growth factor-beta activity in normal and dry eye human tears by CCL-185 cell bioassay. Cornea. 2010 Sep; 29(9):1048-54.
Score: 0.016
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Altered morphology and function of the lacrimal functional unit in protein kinase C{alpha} knockout mice. Invest Ophthalmol Vis Sci. 2010 Nov; 51(11):5592-600.
Score: 0.016
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Autoimmunity at the ocular surface: pathogenesis and regulation. Mucosal Immunol. 2010 Sep; 3(5):425-42.
Score: 0.016
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Desiccating stress promotion of Th17 differentiation by ocular surface tissues through a dendritic cell-mediated pathway. Invest Ophthalmol Vis Sci. 2010 Jun; 51(6):3083-91.
Score: 0.016
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Age-related T-cell cytokine profile parallels corneal disease severity in Sjogren's syndrome-like keratoconjunctivitis sicca in CD25KO mice. Rheumatology (Oxford). 2010 Feb; 49(2):246-58.
Score: 0.016
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Essential role for c-Jun N-terminal kinase 2 in corneal epithelial response to desiccating stress. Arch Ophthalmol. 2009 Dec; 127(12):1625-31.
Score: 0.016
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Spontaneous T cell mediated keratoconjunctivitis in Aire-deficient mice. Br J Ophthalmol. 2009 Sep; 93(9):1260-4.
Score: 0.015
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IL-17 disrupts corneal barrier following desiccating stress. Mucosal Immunol. 2009 May; 2(3):243-53.
Score: 0.015
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Desiccating stress decreases apical corneal epithelial cell size--modulation by the metalloproteinase inhibitor doxycycline. Cornea. 2008 Sep; 27(8):935-40.
Score: 0.014
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Epithelial-immune cell interaction in dry eye. Cornea. 2008 Sep; 27 Suppl 1:S9-11.
Score: 0.014
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Interleukin-1 receptor-1-deficient mice show attenuated production of ocular surface inflammatory cytokines in experimental dry eye. Cornea. 2008 Aug; 27(7):811-7.
Score: 0.014
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Desiccating environmental stress exacerbates autoimmune lacrimal keratoconjunctivitis in non-obese diabetic mice. J Autoimmun. 2008 Jun; 30(4):212-21.
Score: 0.014
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Future directions in therapeutic interventions for conjunctival inflammatory disorders. Curr Opin Allergy Clin Immunol. 2007 Oct; 7(5):450-3.
Score: 0.013
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Dry eye-induced conjunctival epithelial squamous metaplasia is modulated by interferon-gamma. Invest Ophthalmol Vis Sci. 2007 Jun; 48(6):2553-60.
Score: 0.013
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Expression of Th-1 chemokines and chemokine receptors on the ocular surface of C57BL/6 mice: effects of desiccating stress. Invest Ophthalmol Vis Sci. 2007 Jun; 48(6):2561-9.
Score: 0.013
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Strain-related cytokine profiles on the murine ocular surface in response to desiccating stress. Cornea. 2007 Jun; 26(5):579-84.
Score: 0.013
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Effect of topical ophthalmic epinastine and olopatadine on tear volume in mice. Eye Contact Lens. 2006 Dec; 32(6):272-6.
Score: 0.013
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Desiccating stress stimulates expression of matrix metalloproteinases by the corneal epithelium. Invest Ophthalmol Vis Sci. 2006 Aug; 47(8):3293-302.
Score: 0.012
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Apical corneal barrier disruption in experimental murine dry eye is abrogated by methylprednisolone and doxycycline. Invest Ophthalmol Vis Sci. 2006 Jul; 47(7):2847-56.
Score: 0.012
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Expression and regulation of cornified envelope proteins in human corneal epithelium. Invest Ophthalmol Vis Sci. 2006 May; 47(5):1938-46.
Score: 0.012
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Corticosteroid and doxycycline suppress MMP-9 and inflammatory cytokine expression, MAPK activation in the corneal epithelium in experimental dry eye. Exp Eye Res. 2006 Sep; 83(3):526-35.
Score: 0.012
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Hyperosmolar saline is a proinflammatory stress on the mouse ocular surface. Eye Contact Lens. 2005 Sep; 31(5):186-93.
Score: 0.012
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Effect of experimental dry eye on tear sodium concentration in the mouse. Eye Contact Lens. 2005 Jul; 31(4):175-8.
Score: 0.012
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Topical cyclosporine inhibits conjunctival epithelial apoptosis in experimental murine keratoconjunctivitis sicca. Cornea. 2005 Jan; 24(1):80-5.
Score: 0.011
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Matrix metalloproteinase-9 knockout confers resistance to corneal epithelial barrier disruption in experimental dry eye. Am J Pathol. 2005 Jan; 166(1):61-71.
Score: 0.011
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Experimental dry eye stimulates production of inflammatory cytokines and MMP-9 and activates MAPK signaling pathways on the ocular surface. Invest Ophthalmol Vis Sci. 2004 Dec; 45(12):4293-301.
Score: 0.011
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The role of the lacrimal functional unit in the pathophysiology of dry eye. Exp Eye Res. 2004 Mar; 78(3):409-16.
Score: 0.010
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Neurturin-deficient mice develop dry eye and keratoconjunctivitis sicca. Invest Ophthalmol Vis Sci. 2003 Oct; 44(10):4223-9.
Score: 0.010
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A Mouse Model for Corneal Neovascularization by Alkali Burn. J Vis Exp. 2023 06 30; (196).
Score: 0.010
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Apoptosis of ocular surface cells in experimentally induced dry eye. Invest Ophthalmol Vis Sci. 2003 Jan; 44(1):124-9.
Score: 0.010
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Paclitaxel and Urolithin A Prevent Histamine-Induced Neurovascular Breakdown Alike, in an Ex Vivo Rat Eye Model. ACS Chem Neurosci. 2022 07 20; 13(14):2092-2098.
Score: 0.009
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Gut-derived butyrate suppresses ocular surface inflammation. Sci Rep. 2022 03 16; 12(1):4512.
Score: 0.009
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A mouse model of keratoconjunctivitis sicca. Invest Ophthalmol Vis Sci. 2002 Mar; 43(3):632-8.
Score: 0.009
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Experimentally induced dry eye produces ocular surface inflammation and epithelial disease. Adv Exp Med Biol. 2002; 506(Pt A):647-55.
Score: 0.009
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Dry eye and delayed tear clearance: "a call to arms.". Adv Exp Med Biol. 2002; 506(Pt B):739-43.
Score: 0.009
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Expression of the receptor tyrosine kinases, epidermal growth factor receptor, ErbB2, and ErbB3, in human ocular surface epithelia. Cornea. 2001 Jan; 20(1):81-5.
Score: 0.008
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Defining Dry Eye from a Clinical Perspective. Int J Mol Sci. 2020 Dec 04; 21(23).
Score: 0.008
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Rapamycin Eyedrops Increased CD4+Foxp3+ Cells and Prevented Goblet Cell Loss in the Aged Ocular Surface. Int J Mol Sci. 2020 Nov 24; 21(23).
Score: 0.008
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The diagnosis and management of dry eye: a twenty-five-year review. Cornea. 2000 Sep; 19(5):644-9.
Score: 0.008
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Systemic anti-inflammatory therapy aided by double-headed nanoparticles in a canine model of acute intraocular inflammation. Sci Adv. 2020 08; 6(35):eabb7878.
Score: 0.008
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IL-33/ST2/IL-9/IL-9R signaling disrupts ocular surface barrier in allergic inflammation. Mucosal Immunol. 2020 11; 13(6):919-930.
Score: 0.008
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The gut-eye-lacrimal gland-microbiome axis in Sj?gren Syndrome. Ocul Surf. 2020 04; 18(2):335-344.
Score: 0.008
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Dysbiosis Modulates Ocular Surface Inflammatory Response to Liposaccharide. Invest Ophthalmol Vis Sci. 2019 10 01; 60(13):4224-4233.
Score: 0.008
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Short ragweed pollen promotes M2 macrophage polarization via TSLP/TSLPR/OX40L signaling in allergic inflammation. Mucosal Immunol. 2019 09; 12(5):1141-1149.
Score: 0.008
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Age-associated antigen-presenting cell alterations promote dry-eye inducing Th1 cells. Mucosal Immunol. 2019 07; 12(4):897-908.
Score: 0.007
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IL-27 signaling deficiency develops Th17-enhanced Th2-dominant inflammation in murine allergic conjunctivitis model. Allergy. 2019 05; 74(5):910-921.
Score: 0.007
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Reduced Corneal Innervation in the CD25 Null Model of Sj?gren Syndrome. Int J Mol Sci. 2018 Nov 30; 19(12).
Score: 0.007
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The pathology of dry eye: the interaction between the ocular surface and lacrimal glands. Cornea. 1998 Nov; 17(6):584-9.
Score: 0.007
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Advances in the diagnosis and management of keratoconjunctivitis sicca. Curr Opin Ophthalmol. 1998 Aug; 9(4):50-3.
Score: 0.007
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Suppression of Th1-Mediated Keratoconjunctivitis Sicca by Lifitegrast. J Ocul Pharmacol Ther. 2018 09; 34(7):543-549.
Score: 0.007
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Protective role of commensal bacteria in Sj?gren Syndrome. J Autoimmun. 2018 09; 93:45-56.
Score: 0.007
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Near-infrared laser thermal conjunctivoplasty. Sci Rep. 2018 03 01; 8(1):3863.
Score: 0.007
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Sj?gren-Like Lacrimal Keratoconjunctivitis in Germ-Free Mice. Int J Mol Sci. 2018 Feb 13; 19(2).
Score: 0.007
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Reduced intraepithelial corneal nerve density and sensitivity accompany desiccating stress and aging in C57BL/6 mice. Exp Eye Res. 2018 04; 169:91-98.
Score: 0.007
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A unified theory of the role of the ocular surface in dry eye. Adv Exp Med Biol. 1998; 438:643-51.
Score: 0.007
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Identification for Differential Localization of Putative Corneal Epithelial Stem Cells in Mouse and Human. Sci Rep. 2017 07 12; 7(1):5169.
Score: 0.007
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Inhibition of NLRP3 Inflammasome Pathway by Butyrate Improves Corneal Wound Healing in Corneal Alkali Burn. Int J Mol Sci. 2017 Mar 05; 18(3).
Score: 0.006
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Mitochondrial DNA oxidation induces imbalanced activity of NLRP3/NLRP6 inflammasomes by activation of caspase-8 and BRCC36 in dry eye. J Autoimmun. 2017 Jun; 80:65-76.
Score: 0.006
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Pollen/TLR4 Innate Immunity Signaling Initiates IL-33/ST2/Th2 Pathways in Allergic Inflammation. Sci Rep. 2016 10 31; 6:36150.
Score: 0.006
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Age-related spontaneous lacrimal keratoconjunctivitis is accompanied by dysfunctional T regulatory cells. Mucosal Immunol. 2017 05; 10(3):743-756.
Score: 0.006
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Interferon-gamma deficiency protects against aging-related goblet cell loss. Oncotarget. 2016 10 04; 7(40):64605-64614.
Score: 0.006
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Synergistic Cysteamine Delivery Nanowafer as an Efficacious Treatment Modality for Corneal Cystinosis. Mol Pharm. 2016 10 03; 13(10):3468-3477.
Score: 0.006
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Transforming growth factor beta-1 and beta-2 in human tear fluid. Curr Eye Res. 1996 Jun; 15(6):605-14.
Score: 0.006
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Production and secretion of transforming growth factor beta (TGF-beta) by the human lacrimal gland. Curr Eye Res. 1996 Jun; 15(6):615-24.
Score: 0.006
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Dexamethasone Drug Eluting Nanowafers Control Inflammation in Alkali-Burned Corneas Associated With Dry Eye. Invest Ophthalmol Vis Sci. 2016 06 01; 57(7):3222-30.
Score: 0.006
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Inflammatory Response to Lipopolysaccharide on the Ocular Surface in a Murine Dry Eye Model. Invest Ophthalmol Vis Sci. 2016 05 01; 57(6):2443-51.
Score: 0.006
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MMP-8 Is Critical for Dexamethasone Therapy in Alkali-Burned Corneas Under Dry Eye Conditions. J Cell Physiol. 2016 11; 231(11):2506-16.
Score: 0.006
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Differential Effects of Dexamethasone and Doxycycline on Inflammation and MMP Production in Murine Alkali-Burned Corneas Associated with Dry Eye. Ocul Surf. 2016 04; 14(2):242-54.
Score: 0.006
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Clusterin Seals the Ocular Surface Barrier in Mouse Dry Eye. PLoS One. 2015; 10(9):e0138958.
Score: 0.006
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Improvement of Outcome Measures of Dry Eye by a Novel Integrin Antagonist in the Murine Desiccating Stress Model. Invest Ophthalmol Vis Sci. 2015 Sep; 56(10):5888-95.
Score: 0.006
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Dexamethasone nanowafer as an effective therapy for dry eye disease. J Control Release. 2015 Sep 10; 213:168-174.
Score: 0.006
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Desiccating Stress-Induced MMP Production and Activity Worsens Wound Healing in Alkali-Burned Corneas. Invest Ophthalmol Vis Sci. 2015 Jul; 56(8):4908-18.
Score: 0.006
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Altered balance of interleukin-13/interferon-gamma contributes to lacrimal gland destruction and secretory dysfunction in CD25 knockout model of Sj?gren's syndrome. Arthritis Res Ther. 2015 Mar 10; 17:53.
Score: 0.006
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Ocular drug delivery nanowafer with enhanced therapeutic efficacy. ACS Nano. 2015 Feb 24; 9(2):1749-58.
Score: 0.006
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Interpretation of intraocular and serum antibody levels in necrotizing retinitis. Retina. 1995; 15(3):233-40.
Score: 0.006
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Desiccating stress-induced chemokine expression in the epithelium is dependent on upregulation of NKG2D/RAE-1 and release of IFN-? in experimental dry eye. J Immunol. 2014 Nov 15; 193(10):5264-72.
Score: 0.005
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A potential link between bacterial pathogens and allergic conjunctivitis by dendritic cells. Exp Eye Res. 2014 Mar; 120:118-26.
Score: 0.005
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Ocular surface disease and dacryoadenitis in aging C57BL/6 mice. Am J Pathol. 2014 Mar; 184(3):631-43.
Score: 0.005
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Chemokine receptors CCR6 and CXCR3 are necessary for CD4(+) T cell mediated ocular surface disease in experimental dry eye disease. PLoS One. 2013; 8(11):e78508.
Score: 0.005
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Effect of desiccating stress on mouse meibomian gland function. Ocul Surf. 2014 Jan; 12(1):59-68.
Score: 0.005
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CD8? cells regulate the T helper-17 response in an experimental murine model of Sj?gren syndrome. Mucosal Immunol. 2014 Mar; 7(2):417-27.
Score: 0.005
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Dendritic cell-derived thrombospondin-1 is critical for the generation of the ocular surface Th17 response to desiccating stress. J Leukoc Biol. 2013 Dec; 94(6):1293-301.
Score: 0.005
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Morphologic alterations of the palpebral conjunctival epithelium in a dry eye model. Cornea. 2013 Apr; 32(4):483-90.
Score: 0.005
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Toll-like receptor expression and activation in mice with experimental dry eye. Invest Ophthalmol Vis Sci. 2013 Feb 28; 54(2):1554-63.
Score: 0.005
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Potential autocrine regulation of interleukin-33/ST2 signaling of dendritic cells in allergic inflammation. Mucosal Immunol. 2013 Sep; 6(5):921-30.
Score: 0.005
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Infectious endophthalmitis. Infect Dis Clin North Am. 1992 Dec; 6(4):859-73.
Score: 0.005
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A native-like corneal construct using donor corneal stroma for tissue engineering. PLoS One. 2012; 7(11):e49571.
Score: 0.005
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Resolvin E1 (RX-10001) reduces corneal epithelial barrier disruption and protects against goblet cell loss in a murine model of dry eye. Cornea. 2012 Nov; 31(11):1299-303.
Score: 0.005
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Deletion of interferon-? delays onset and severity of dacryoadenitis in CD25KO mice. Arthritis Res Ther. 2012 Nov 01; 14(6):R234.
Score: 0.005
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Identification of human fibroblast cell lines as a feeder layer for human corneal epithelial regeneration. PLoS One. 2012; 7(6):e38825.
Score: 0.005
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NK cells promote Th-17 mediated corneal barrier disruption in dry eye. PLoS One. 2012; 7(5):e36822.
Score: 0.005
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Low humidity environmental challenge causes barrier disruption and cornification of the mouse corneal epithelium via a c-jun N-terminal kinase 2 (JNK2) pathway. Exp Eye Res. 2012 Jan; 94(1):150-6.
Score: 0.004
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Ocular surface APCs are necessary for autoreactive T cell-mediated experimental autoimmune lacrimal keratoconjunctivitis. J Immunol. 2011 Oct 01; 187(7):3653-62.
Score: 0.004
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Short ragweed pollen triggers allergic inflammation through Toll-like receptor 4-dependent thymic stromal lymphopoietin/OX40 ligand/OX40 signaling pathways. J Allergy Clin Immunol. 2011 Dec; 128(6):1318-1325.e2.
Score: 0.004
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An immunoprotective privilege of corneal epithelial stem cells against Th17 inflammatory stress by producing glial cell-derived neurotrophic factor. Stem Cells. 2010 Dec; 28(12):2172-81.
Score: 0.004
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Spontaneous autoimmune dacryoadenitis in aged CD25KO mice. Am J Pathol. 2010 Aug; 177(2):744-53.
Score: 0.004
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TSLP and downstream molecules in experimental mouse allergic conjunctivitis. Invest Ophthalmol Vis Sci. 2010 Jun; 51(6):3076-82.
Score: 0.004
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Induction of Th17 differentiation by corneal epithelial-derived cytokines. J Cell Physiol. 2010 Jan; 222(1):95-102.
Score: 0.004
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Complications of intraocular antimicrobial agents. Int Ophthalmol Clin. 1989; 29(3):188-94.
Score: 0.004
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In vitro expanded CD4+CD25+Foxp3+ regulatory T cells maintain a normal phenotype and suppress immune-mediated ocular surface inflammation. Invest Ophthalmol Vis Sci. 2008 Dec; 49(12):5434-40.
Score: 0.004
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Intravitreal vancomycin. Retinal toxicity, clearance, and interaction with gentamicin. Arch Ophthalmol. 1987 Jun; 105(6):831-7.
Score: 0.003
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Desiccating stress induces T cell-mediated Sj?gren's Syndrome-like lacrimal keratoconjunctivitis. J Immunol. 2006 Apr 01; 176(7):3950-7.
Score: 0.003
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Cell size correlates with phenotype and proliferative capacity in human corneal epithelial cells. Stem Cells. 2006 Feb; 24(2):368-75.
Score: 0.003
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ABCG2 transporter identifies a population of clonogenic human limbal epithelial cells. Stem Cells. 2005; 23(1):63-73.
Score: 0.003
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Endophthalmitis therapy: changing antibiotic sensitivity patterns and current therapeutic recommendations. Arch Ophthalmol. 1991 Feb; 109(2):175-6.
Score: 0.001