CRISTIANCOARFACRISTIAN COARFA0.000000000000000.000000000000001149COARFA, CRISTIANAssociate Professorprns:coAuthorOfcoauthor ofprns:emailEncryptedemail addressprns:endDateend dateFaculty Rankprns:fullNamefull nameprns:grantAwardedBygrant awarded byprns:hasAuthorListauthor listprns:hasFacultyRankhas faculty rankprns:hasNetworkhas networkprns:hasPublicationVenuepublished inprns:informationResourceReferenceinformation resource referenceprns:isPrimaryPositionis primary positionprns:latitudelatitudeprns:longitudelongitudeprns:mainImagephotoprns:maxWeightmaximum weightprns:medlineTAjournal title abbreviationprns:meshDescriptorUIMeSH DescriptorUIprns:meshSemanticGroupNameMeSH semantic group nameprns:minWeightminimum weightprns:numberOfAuthorsnumber of authorsprns:numberOfConnectionsnumber of connectionsprns:numberOfPublicationsnumber of publicationsprns:personIdPerson IDprns:personInPrimaryPositionperson in primary positionprns:physicalNeighborOfphysical neighborprns:positionInDepartmentposition in departmentprns:positionInDivisionposition in divisionprns:predicateNodepredicate nodeprns:principalInvestigatorNameprincipal investigator nameprns:publicationDatepublication dateprns:similarTosimilar toprns:sortOrdersort orderprns:startDatestart dateprns:uniquenessWeightuniqueness weightprns:yearyearAcademic ArticleArticleDocumentbibo:pmidPubMed IdentifierAddressvivo:address1address line 1vivo:addressCitycityvivo:addressPostalCodepostal codevivo:addressStatestate or provinceAgreementvivo:authorInAuthorshipselected publicationsvivo:authorRankauthor rank in publicationAuthorshipDepartmentDivisionGrantvivo:hasResearchArearesearch areasvivo:hasResearcherRoleresearch activitiesvivo:hrJobTitleHR job titleInformation Resourcevivo:linkAnchorTextlink anchor textvivo:linkedAuthorlinked authorvivo:linkedInformationResourcelinked information resourcevivo:mailingAddressmailing addressvivo:personInPositionpositionsPositionvivo:positionInOrganizationposition in organizationvivo:preferredTitlepreferred titleResearcher Rolevivo:researcherRoleOfresearcher role ofRolevivo:roleContributesTocontributes tovivo:sponsorAwardIdsponsor award idURLLinkvivo:webpagewebpagerdf:predicatepredicaterdf:typetyperdfs:labellabelConceptAgentfoaf:firstNamefirst namefoaf:lastNamelast nameOrganizationPersonAuthorship 156537225148579Bliss-Moreau M, Coarfa C, Gunaratne PH, Guitart J, Krett NL, Rosen STThe Journal of investigative dermatologyIdentification of p38? as a therapeutic target for the treatment of S?zary syndrome. J Invest Dermatol. 2015 Feb; 135(2):599-608.J Invest Dermatol2014-08-22T00:00:002014Identification of p38? as a therapeutic target for the treatment of S?zary syndrome.25368194Menon DU, Coarfa C, Xiao W, Gunaratne PH, Meller VHProceedings of the National Academy of Sciences of the United States of AmericasiRNAs from an X-linked satellite repeat promote X-chromosome recognition in Drosophila melanogaster. Proc Natl Acad Sci U S A. 2014 Nov 18; 111(46):16460-5.Proc Natl Acad Sci U S A2014-11-03T00:00:002014siRNAs from an X-linked satellite repeat promote X-chromosome recognition in Drosophila melanogaster.25489091He B, Lanz RB, Fiskus W, Geng C, Yi P, Hartig SM, Rajapakshe K, Shou J, Wei L, Shah SS, Foley C, Chew SA, Eedunuri VK, Bedoya DJ, Feng Q, Minami T, Mitsiades CS, Frolov A, Weigel NL, Hilsenbeck SG, Rosen DG, Palzkill T, Ittmann MM, Song Y, Coarfa C, O'Malley BW, Mitsiades NProceedings of the National Academy of Sciences of the United States of AmericaGATA2 facilitates steroid receptor coactivator recruitment to the androgen receptor complex. Proc Natl Acad Sci U S A. 2014 Dec 23; 111(51):18261-6.Proc Natl Acad Sci U S A2014-12-08T00:00:002014GATA2 facilitates steroid receptor coactivator recruitment to the androgen receptor complex.Authorship 84475Authorship 866673Authorship 905142Authorship 907916Authorship 984663Authorship 998814Authorship 1092681Authorship 1613726Authorship 1616022Authorship 1616215Authorship 16168512Authorship 1617209Authorship 1617702525409149Venkatanarayan A, Raulji P, Norton W, Chakravarti D, Coarfa C, Su X, Sandur SK, Ramirez MS, Lee J, Kingsley CV, Sananikone EF, Rajapakshe K, Naff K, Parker-Thornburg J, Bankson JA, Tsai KY, Gunaratne PH, Flores ERNatureIAPP-driven metabolic reprogramming induces regression of p53-deficient tumours in vivo. Nature. 2015 Jan 29; 517(7536):626-30.Nature2014-11-17T00:00:002014IAPP-driven metabolic reprogramming induces regression of p53-deficient tumours in vivo.25664849Dasgupta S, Putluri N, Long W, Zhang B, Wang J, Kaushik AK, Arnold JM, Bhowmik SK, Stashi E, Brennan CA, Rajapakshe K, Coarfa C, Mitsiades N, Ittmann MM, Chinnaiyan AM, Sreekumar A, O'Malley BWThe Journal of clinical investigationCoactivator SRC-2-dependent metabolic reprogramming mediates prostate cancer survival and metastasis. J Clin Invest. 2015 Mar 02; 125(3):1174-88.J Clin Invest2015-02-09T00:00:002015Coactivator SRC-2-dependent metabolic reprogramming mediates prostate cancer survival and metastasis.25691127Elliott G, Hong C, Xing X, Zhou X, Li D, Coarfa C, Bell RJ, Maire CL, Ligon KL, Sigaroudinia M, Gascard P, Tlsty TD, Harris RA, Schalkwyk LC, Bilenky M, Mill J, Farnham PJ, Kellis M, Marra MA, Milosavljevic A, Hirst M, Stormo GD, Wang T, Costello JFNature communicationsIntermediate DNA methylation is a conserved signature of genome regulation. Nat Commun. 2015 Feb 18; 6:6363.Nat Commun2015-02-18T00:00:002015Intermediate DNA methylation is a conserved signature of genome regulation.25691256Amin V, Harris RA, Onuchic V, Jackson AR, Charnecki T, Paithankar S, Lakshmi Subramanian S, Riehle K, Coarfa C, Milosavljevic ANature communicationsEpigenomic footprints across 111 reference epigenomes reveal tissue-specific epigenetic regulation of lincRNAs. Nat Commun. 2015 Feb 18; 6:6370.Nat Commun2015-02-18T00:00:002015Epigenomic footprints across 111 reference epigenomes reveal tissue-specific epigenetic regulation of lincRNAs.25693563Roadmap Epigenomics Consortium, Kundaje A, Meuleman W, Ernst J, Bilenky M, Yen A, Heravi-Moussavi A, Kheradpour P, Zhang Z, Wang J, Ziller MJ, Amin V, Whitaker JW, Schultz MD, Ward LD, Sarkar A, Quon G, Sandstrom RS, Eaton ML, Wu YC, Pfenning AR, Wang X, Claussnitzer M, Liu Y, Coarfa C, Harris RA, Shoresh N, Epstein CB, Gjoneska E, Leung D, Xie W, Hawkins RD, Lister R, Hong C, Gascard P, Mungall AJ, Moore R, Chuah E, Tam A, Canfield TK, Hansen RS, Kaul R, Sabo PJ, Bansal MS, Carles A, Dixon JR, Farh KH, Feizi S, Karlic R, Kim AR, Kulkarni A, Li D, Lowdon R, Elliott G, Mercer TR, Neph SJ, Onuchic V, Polak P, Rajagopal N, Ray P, Sallari RC, Siebenthall KT, Sinnott-Armstrong NA, Stevens M, Thurman RE, Wu J, Zhang B, Zhou X, Beaudet AE, Boyer LA, De Jager PL, Farnham PJ, Fisher SJ, Haussler D, Jones SJ, Li W, Marra MA, McManus MT, Sunyaev S, Thomson JA, Tlsty TD, Tsai LH, Wang W, Waterland RA, Zhang MQ, Chadwick LH, Bernstein BE, Costello JF, Ecker JR, Hirst M, Meissner A, Milosavljevic A, Ren B, Stamatoyannopoulos JA, Wang T, Kellis MNatureIntegrative analysis of 111 reference human epigenomes. Nature. 2015 Feb 19; 518(7539):317-30.Nature2015-02-19T00:00:002015Integrative analysis of 111 reference human epigenomes.25733895Kannan K, Coarfa C, Chao PW, Luo L, Wang Y, Brinegar AE, Hawkins SM, Milosavljevic A, Matzuk MM, Yen LProceedings of the National Academy of Sciences of the United States of AmericaRecurrent BCAM-AKT2 fusion gene leads to a constitutively activated AKT2 fusion kinase in high-grade serous ovarian carcinoma. Proc Natl Acad Sci U S A. 2015 Mar 17; 112(11):E1272-7.Proc Natl Acad Sci U S A2015-03-02T00:00:002015Recurrent BCAM-AKT2 fusion gene leads to a constitutively activated AKT2 fusion kinase in high-grade serous ovarian carcinoma.Authorship 317896Experimental TherapeuticsGynecological Oncology & Reproductive MedicineLeukemiaMolecular & Cellular OncologySystems BiologyMD AndersonMIEN-CHIEHUNGMIEN-CHIE HUNG8427HUNG, MIEN-CHIEProfessorHAGOP MKANTARJIANHAGOP M KANTARJIAN8501KANTARJIAN, HAGOP MProfessorGORDON BMILLSGORDON B MILLS8620MILLS, GORDON BProfessorGEORGE ACALINGEORGE A CALIN9408CALIN, GEORGE AProfessorANIL KSOODANIL K SOOD9048SOOD, ANIL KProfessorAuthorship 262085726000884Bhardwaj A, Ganesan N, Tachibana K, Rajapakshe K, Albarracin CT, Gunaratne PH, Coarfa C, Bedrosian IPloS oneAnnexin A1 Preferentially Predicts Poor Prognosis of Basal-Like Breast Cancer Patients by Activating mTOR-S6 Signaling. PLoS One. 2015; 10(5):e0127678.PLoS One2015-05-22T00:00:002015Annexin A1 Preferentially Predicts Poor Prognosis of Basal-Like Breast Cancer Patients by Activating mTOR-S6 Signaling.Authorship 8350514One Baylor PlazaHouston, 77030TXAuthorship 2966764Authorship 2972366Authorship 2975284Authorship 2996018Authorship 3000407Authorship 3007262Authorship 30112116Authorship 3011514Authorship 3014105Authorship 3018602Authorship 3020345Authorship 3040907Authorship 3053981025847065Lin F, Marcelo KL, Rajapakshe K, Coarfa C, Dean A, Wilganowski N, Robinson H, Sevick E, Bissig KD, Goldie LC, Means AR, York BHepatology (Baltimore, Md.)The camKK2/camKIV relay is an essential regulator of hepatic cancer. Hepatology. 2015 Aug; 62(2):505-20.Hepatology2015-05-09T00:00:002015The camKK2/camKIV relay is an essential regulator of hepatic cancer.26062908Silver MJ, Kessler NJ, Hennig BJ, Dominguez-Salas P, Laritsky E, Baker MS, Coarfa C, Hernandez-Vargas H, Castelino JM, Routledge MN, Gong YY, Herceg Z, Lee YS, Lee K, Moore SE, Fulford AJ, Prentice AM, Waterland RAGenome biologyIndependent genomewide screens identify the tumor suppressor VTRNA2-1 as a human epiallele responsive to periconceptional environment. Genome Biol. 2015 Jun 11; 16:118.Genome Biol2015-06-11T00:00:002015Independent genomewide screens identify the tumor suppressor VTRNA2-1 as a human epiallele responsive to periconceptional environment.26066330Eedunuri VK, Rajapakshe K, Fiskus W, Geng C, Chew SA, Foley C, Shah SS, Shou J, Mohamed JS, Coarfa C, O'Malley BW, Mitsiades NMolecular endocrinology (Baltimore, Md.)miR-137 Targets p160 Steroid Receptor Coactivators SRC1, SRC2, and SRC3 and Inhibits Cell Proliferation. Mol Endocrinol. 2015 Aug; 29(8):1170-83.Mol Endocrinol2015-06-12T00:00:002015miR-137 Targets p160 Steroid Receptor Coactivators SRC1, SRC2, and SRC3 and Inhibits Cell Proliferation.26254443Sun B, Shah B, Fiskus W, Qi J, Rajapakshe K, Coarfa C, Li L, Devaraj SG, Sharma S, Zhang L, Wang ML, Saenz DT, Krieger S, Bradner JE, Bhalla KNBloodSynergistic activity of BET protein antagonist-based combinations in mantle cell lymphoma cells sensitive or resistant to ibrutinib. Blood. 2015 Sep 24; 126(13):1565-74.Blood2015-08-07T00:00:002015Synergistic activity of BET protein antagonist-based combinations in mantle cell lymphoma cells sensitive or resistant to ibrutinib.26300228Chang CH, Zhang M, Rajapakshe K, Coarfa C, Edwards D, Huang S, Rosen JMStem cell reportsMammary Stem Cells and Tumor-Initiating Cells Are More Resistant to Apoptosis and Exhibit Increased DNA Repair Activity in Response to DNA Damage. Stem Cell Reports. 2015 Sep 08; 5(3):378-91.Stem Cell Reports2015-08-20T00:00:002015Mammary Stem Cells and Tumor-Initiating Cells Are More Resistant to Apoptosis and Exhibit Increased DNA Repair Activity in Response to DNA Damage.26305679Blessing AM, Ganesan S, Rajapakshe K, Ying Sung Y, Reddy Bollu L, Shi Y, Cheung E, Coarfa C, Chang JT, McDonnell DP, Frigo DEMolecular endocrinology (Baltimore, Md.)Identification of a Novel Coregulator, SH3YL1, That Interacts With the Androgen Receptor N-Terminus. Mol Endocrinol. 2015 Oct; 29(10):1426-39.Mol Endocrinol2015-08-25T00:00:002015Identification of a Novel Coregulator, SH3YL1, That Interacts With the Androgen Receptor N-Terminus.26378018Shafi AA, Putluri V, Arnold JM, Tsouko E, Maity S, Roberts JM, Coarfa C, Frigo DE, Putluri N, Sreekumar A, Weigel NLOncotargetDifferential regulation of metabolic pathways by androgen receptor (AR) and its constitutively active splice variant, AR-V7, in prostate cancer cells. Oncotarget. 2015 Oct 13; 6(31):31997-2012.Oncotarget2015-10-13T00:00:002015Differential regulation of metabolic pathways by androgen receptor (AR) and its constitutively active splice variant, AR-V7, in prostate cancer cells.26426411Jonsson P, Coarfa C, Mesmar F, Raz T, Rajapakshe K, Thompson JF, Gunaratne PH, Williams CMolecular endocrinology (Baltimore, Md.)Single-Molecule Sequencing Reveals Estrogen-Regulated Clinically Relevant lncRNAs in Breast Cancer. Mol Endocrinol. 2015 Nov; 29(11):1634-45.Mol Endocrinol2015-10-01T00:00:002015Single-Molecule Sequencing Reveals Estrogen-Regulated Clinically Relevant lncRNAs in Breast Cancer.26487680Fleet T, Zhang B, Lin F, Zhu B, Dasgupta S, Stashi E, Tackett B, Thevananther S, Rajapakshe KI, Gonzales N, Dean A, Mao J, Timchenko N, Malovannaya A, Qin J, Coarfa C, DeMayo F, Dacso CC, Foulds CE, O'Malley BW, York BProceedings of the National Academy of Sciences of the United States of AmericaSRC-2 orchestrates polygenic inputs for fine-tuning glucose homeostasis. Proc Natl Acad Sci U S A. 2015 Nov 03; 112(44):E6068-77.Proc Natl Acad Sci U S A2015-10-20T00:00:002015SRC-2 orchestrates polygenic inputs for fine-tuning glucose homeostasis.26492273Kannan K, Kordestani GK, Galagoda A, Coarfa C, Yen LCancersAberrant MUC1-TRIM46-KRTCAP2 Chimeric RNAs in High-Grade Serous Ovarian Carcinoma. 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FASEB J. 2016 07; 30(7):2541-8.FASEB J2016-03-31T00:00:002016Maternal exercise during pregnancy promotes physical activity in adult offspring.26683771Zhang S, Wei JS, Li SQ, Badgett TC, Song YK, Agarwal S, Coarfa C, Tolman C, Hurd L, Liao H, He J, Wen X, Liu Z, Thiele CJ, Westermann F, Asgharzadeh S, Seeger RC, Maris JM, Guidry Auvil JM, Smith MA, Kolaczyk ED, Shohet J, Khan JCancer lettersMYCN controls an alternative RNA splicing program in high-risk metastatic neuroblastoma. Cancer Lett. 2016 Feb 28; 371(2):214-24.Cancer Lett2015-12-10T00:00:002015MYCN controls an alternative RNA splicing program in high-risk metastatic neuroblastoma.Authorship 3199243Authorship 32063315Authorship 3213977Authorship 32264518Authorship 3229176Authorship 3230905Authorship 3232769Authorship 3236081626362934Foulds CE, Panigrahi AK, Coarfa C, Lanz RB, O'Malley BWCurrent topics in microbiology and immunologyLong Noncoding RNAs as Targets and Regulators of Nuclear Receptors. Curr Top Microbiol Immunol. 2016; 394:143-76.Curr Top Microbiol Immunol2016-01-01T00:00:002016Long Noncoding RNAs as Targets and Regulators of Nuclear Receptors.26802582von Rundstedt FC, Rajapakshe K, Ma J, Arnold JM, Gohlke J, Putluri V, Krishnapuram R, Piyarathna DB, Lotan Y, G?dde D, Roth S, St?rkel S, Levitt JM, Michailidis G, Sreekumar A, Lerner SP, Coarfa C, Putluri NThe Journal of urologyIntegrative Pathway Analysis of Metabolic Signature in Bladder Cancer: A Linkage to The Cancer Genome Atlas Project and Prediction of Survival. J Urol. 2016 06; 195(6):1911-9.J Urol2016-01-21T00:00:002016Integrative Pathway Analysis of Metabolic Signature in Bladder Cancer: A Linkage to The Cancer Genome Atlas Project and Prediction of Survival.26923594Park JH, Vithayathil S, Kumar S, Sung PL, Dobrolecki LE, Putluri V, Bhat VB, Bhowmik SK, Gupta V, Arora K, Wu D, Tsouko E, Zhang Y, Maity S, Donti TR, Graham BH, Frigo DE, Coarfa C, Yotnda P, Putluri N, Sreekumar A, Lewis MT, Creighton CJ, Wong LC, Kaipparettu BACell reportsFatty Acid Oxidation-Driven Src Links Mitochondrial Energy Reprogramming and Oncogenic Properties in Triple-Negative Breast Cancer. Cell Rep. 2016 Mar 08; 14(9):2154-2165.Cell Rep2016-02-25T00:00:002016Fatty Acid Oxidation-Driven Src Links Mitochondrial Energy Reprogramming and Oncogenic Properties in Triple-Negative Breast Cancer.27103661Shivanna B, Maity S, Zhang S, Patel A, Jiang W, Wang L, Welty SE, Belmont J, Coarfa C, Moorthy BToxicological sciences : an official journal of the Society of ToxicologyGene Expression Profiling Identifies Cell Proliferation and Inflammation as the Predominant Pathways Regulated by Aryl Hydrocarbon Receptor in Primary Human Fetal Lung Cells Exposed to Hyperoxia. 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J Invest Dermatol. 2016 09; 136(9):1920-1924.J Invest Dermatol2016-06-09T00:00:002016MEK Is a Therapeutic and Chemopreventative Target in Squamous Cell Carcinoma.27409825Ochsner SA, Tsimelzon A, Dong J, Coarfa C, McKenna NJMolecular endocrinology (Baltimore, Md.)Research Resource: A Reference Transcriptome for Constitutive Androstane Receptor and Pregnane X Receptor Xenobiotic Signaling. Mol Endocrinol. 2016 Aug; 30(8):937-48.Mol Endocrinol2016-07-13T00:00:002016Research Resource: A Reference Transcriptome for Constitutive Androstane Receptor and Pregnane X Receptor Xenobiotic Signaling.27036018Pan Y, Robertson G, Pedersen L, Lim E, Hernandez-Herrera A, Rowat AC, Patil SL, Chan CK, Wen Y, Zhang X, Basu-Roy U, Mansukhani A, Chu A, Sipahimalani P, Bowlby R, Brooks D, Thiessen N, Coarfa C, Ma Y, Moore RA, Schein JE, Mungall AJ, Liu J, Pecot CV, Sood AK, Jones SJ, Marra MA, Gunaratne PHOncotargetmiR-509-3p is clinically significant and strongly attenuates cellular migration and multi-cellular spheroids in ovarian cancer. Oncotarget. 2016 May 03; 7(18):25930-48.Oncotarget2016-05-03T00:00:002016miR-509-3p is clinically significant and strongly attenuates cellular migration and multi-cellular spheroids in ovarian cancer.27432117Fleet T, Stashi E, Zhu B, Rajapakshe K, Marcelo KL, Kettner NM, Gorman BK, Coarfa C, Fu L, O'Malley BW, York BJournal of biological rhythmsGenetic and Environmental Models of Circadian Disruption Link SRC-2 Function to Hepatic Pathology. J Biol Rhythms. 2016 10; 31(5):443-60.J Biol Rhythms2016-07-17T00:00:002016Genetic and Environmental Models of Circadian Disruption Link SRC-2 Function to Hepatic Pathology.Authorship 326382227574101Chitsazzadeh V, Coarfa C, Drummond JA, Nguyen T, Joseph A, Chilukuri S, Charpiot E, Adelmann CH, Ching G, Nguyen TN, Nicholas C, Thomas VD, Migden M, MacFarlane D, Thompson E, Shen J, Takata Y, McNiece K, Polansky MA, Abbas HA, Rajapakshe K, Gower A, Spira A, Covington KR, Xiao W, Gunaratne P, Pickering C, Frederick M, Myers JN, Shen L, Yao H, Su X, Rapini RP, Wheeler DA, Hawk ET, Flores ER, Tsai KYNature communicationsCross-species identification of genomic drivers of squamous cell carcinoma development across preneoplastic intermediates. Nat Commun. 2016 08 30; 7:12601.Nat Commun2016-08-30T00:00:002016Cross-species identification of genomic drivers of squamous cell carcinoma development across preneoplastic intermediates.Authorship 3267738Authorship 326918727573846Iwamori N, Tominaga K, Sato T, Riehle K, Iwamori T, Ohkawa Y, Coarfa C, Ono E, Matzuk MMProceedings of the National Academy of Sciences of the United States of AmericaMRG15 is required for pre-mRNA splicing and spermatogenesis. Proc Natl Acad Sci U S A. 2016 09 13; 113(37):E5408-15.Proc Natl Acad Sci U S A2016-08-29T00:00:002016MRG15 is required for pre-mRNA splicing and spermatogenesis.Authorship 3276651127627810Ware MJ, Keshishian V, Law JJ, Ho JC, Favela CA, Rees P, Smith B, Mohammad S, Hwang RF, Rajapakshe K, Coarfa C, Huang S, Edwards DP, Corr SJ, Godin B, Curley SABiomaterialsGeneration of an in?vitro 3D PDAC stroma rich spheroid model. Biomaterials. 2016 11; 108:129-42.Biomaterials2016-09-02T00:00:002016Generation of an in?vitro 3D PDAC stroma rich spheroid model.19056696Hampton OA, Den Hollander P, Miller CA, Delgado DA, Li J, Coarfa C, Harris RA, Richards S, Scherer SE, Muzny DM, Gibbs RA, Lee AV, Milosavljevic AGenome researchA sequence-level map of chromosomal breakpoints in the MCF-7 breast cancer cell line yields insights into the evolution of a cancer genome. Genome Res. 2009 Feb; 19(2):167-77.Genome Res2008-12-03T00:00:002008A sequence-level map of chromosomal breakpoints in the MCF-7 breast cancer cell line yields insights into the evolution of a cancer genome.19730684Ma L, Buchold GM, Greenbaum MP, Roy A, Burns KH, Zhu H, Han DY, Harris RA, Coarfa C, Gunaratne PH, Yan W, Matzuk MMPLoS geneticsGASZ is essential for male meiosis and suppression of retrotransposon expression in the male germline. 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Genome Biol. 2018 01 09; 19(1):2.Genome Biol2018-01-09T00:00:002018Epigenetic supersimilarity of monozygotic twin pairs.29317431Auguste G, Gurha P, Lombardi R, Coarfa C, Willerson JT, Marian AJCirculation researchSuppression of Activated FOXO Transcription Factors in the Heart Prolongs Survival in a Mouse Model of Laminopathies. Circ Res. 2018 03 02; 122(5):678-692.Circ Res2018-01-09T00:00:002018Suppression of Activated FOXO Transcription Factors in the Heart Prolongs Survival in a Mouse Model of Laminopathies.true1ProfessorProfessor29752313DiNardo AR, Nishiguchi T, Mace EM, Rajapakshe K, Mtetwa G, Kay A, Maphalala G, Secor WE, Mejia R, Orange JS, Coarfa C, Bhalla KN, Graviss EA, Mandalakas AM, Makedonas GJournal of immunology (Baltimore, Md. : 1950)Schistosomiasis Induces Persistent DNA Methylation and Tuberculosis-Specific Immune Changes. J Immunol. 2018 07 01; 201(1):124-133.J Immunol2018-05-11T00:00:002018Schistosomiasis Induces Persistent DNA Methylation and Tuberculosis-Specific Immune Changes.29755654Agarwal S, Milazzo G, Rajapakshe K, Bernardi R, Chen Z, Barbieri E, Koster J, Perini G, Coarfa C, Shohet JMOncotargetMYCN acts as a direct co-regulator of p53 in MYCN amplified neuroblastoma. Oncotarget. 2018 04 17; 9(29):20323-20338.Oncotarget2018-04-17T00:00:002018MYCN acts as a direct co-regulator of p53 in MYCN amplified neuroblastoma.D019175Physiology69726600.473537DNA MethylationD011944Chemicals & Drugs2908750.646115Receptors, Androgentrue1Assistant ProfessorAssistant Professortrue1Adjunct Associate ProfessorAdjunct Associate Professor30288358Jayaraman P, Parikh F, Newton JM, Hanoteau A, Rivas C, Krupar R, Rajapakshe K, Pathak R, Kanthaswamy K, MacLaren C, Huang S, Coarfa C, Spanos C, Edwards DP, Parihar R, Sikora AGOncoimmunologyTGF-?1 programmed myeloid-derived suppressor cells (MDSC) acquire immune-stimulating and tumor killing activity capable of rejecting established tumors in combination with radiotherapy. Oncoimmunology. 2018; 7(10):e1490853.Oncoimmunology2018-07-26T00:00:002018TGF-?1 programmed myeloid-derived suppressor cells (MDSC) acquire immune-stimulating and tumor killing activity capable of rejecting established tumors in combination with radiotherapy.29771332Morriss GR, Rajapakshe K, Huang S, Coarfa C, Cooper TAHuman molecular geneticsMechanisms of skeletal muscle wasting in a mouse model for myotonic dystrophy type 1. Hum Mol Genet. 2018 08 15; 27(16):2789-2804.Hum Mol Genet2018-08-15T00:00:002018Mechanisms of skeletal muscle wasting in a mouse model for myotonic dystrophy type 1.D018496Disorders321330.831797HyperoxiaAuthorship 91642312Authorship 9182557Authorship 9245389Authorship 9246154Authorship 9280086Authorship 92912811Authorship 92969411Authorship 9308737Authorship 9310348Authorship 9310353Authorship 9310603Authorship 93115812Authorship 93133224Authorship 93171812D035683Chemicals & Drugs75129430.373492MicroRNAsAuthorship 9333836Authorship 9335479Authorship 9347268Authorship 93514611Authorship 9354599Authorship 93677911Authorship 9375358Authorship 9382298Authorship 9387383Authorship 9391279Authorship 940491228955502Kim H, Li F, He Q, Deng T, Xu J, Jin F, Coarfa C, Putluri N, Liu D, Songyang ZCell discoverySystematic analysis of human telomeric dysfunction using inducible telosome/shelterin CRISPR/Cas9 knockout cells. Cell Discov. 2017; 3:17034.Cell Discov2017-09-26T00:00:002017Systematic analysis of human telomeric dysfunction using inducible telosome/shelterin CRISPR/Cas9 knockout cells.29507687Wijayatunga NN, Pahlavani M, Kalupahana NS, Kottapalli KR, Gunaratne PH, Coarfa C, Ramalingam L, Moustaid-Moussa NOncotargetAn integrative transcriptomic approach to identify depot differences in genes and microRNAs in adipose tissues from high fat fed mice. Oncotarget. 2018 Feb 06; 9(10):9246-9261.Oncotarget2018-01-13T00:00:002018An integrative transcriptomic approach to identify depot differences in genes and microRNAs in adipose tissues from high fat fed mice.30011843Purwaha P, Gu F, Piyarathna DWB, Rajendiran T, Ravindran A, Omilian AR, Jiralerspong S, Das G, Morrison C, Ambrosone C, Coarfa C, Putluri N, Sreekumar AMetabolitesUnbiased Lipidomic Profiling of Triple-Negative Breast Cancer Tissues Reveals the Association of Sphingomyelin Levels with Patient Disease-Free Survival. Metabolites. 2018 Jul 13; 8(3).Metabolites2018-07-13T00:00:002018Unbiased Lipidomic Profiling of Triple-Negative Breast Cancer Tissues Reveals the Association of Sphingomyelin Levels with Patient Disease-Free Survival.30135250Cho RJ, Alexandrov LB, den Breems NY, Atanasova VS, Farshchian M, Purdom E, Nguyen TN, Coarfa C, Rajapakshe K, Prisco M, Sahu J, Tassone P, Greenawalt EJ, Collisson EA, Wu W, Yao H, Su X, Guttmann-Gruber C, Hofbauer JP, Hashmi R, Fuentes I, Benz SC, Golovato J, Ehli EA, Davis CM, Davies GE, Covington KR, Murrell DF, Salas-Alanis JC, Palisson F, Bruckner AL, Robinson W, Has C, Bruckner-Tuderman L, Titeux M, Jonkman MF, Rashidghamat E, Lwin SM, Mellerio JE, McGrath JA, Bauer JW, Hovnanian A, Tsai KY, South APScience translational medicineAPOBEC mutation drives early-onset squamous cell carcinomas in recessive dystrophic epidermolysis bullosa. Sci Transl Med. 2018 08 22; 10(455).Sci Transl Med2018-08-22T00:00:002018APOBEC mutation drives early-onset squamous cell carcinomas in recessive dystrophic epidermolysis bullosa.30139913Onuchic V, Lurie E, Carrero I, Pawliczek P, Patel RY, Rozowsky J, Galeev T, Huang Z, Altshuler RC, Zhang Z, Harris RA, Coarfa C, Ashmore L, Bertol JW, Fakhouri WD, Yu F, Kellis M, Gerstein M, Milosavljevic AScience (New York, N.Y.)Allele-specific epigenome maps reveal sequence-dependent stochastic switching at regulatory loci. Science. 2018 09 28; 361(6409).Science2018-08-23T00:00:002018Allele-specific epigenome maps reveal sequence-dependent stochastic switching at regulatory loci.30261280Pahlavani M, Wijayatunga NN, Kalupahana NS, Ramalingam L, Gunaratne PH, Coarfa C, Rajapakshe K, Kottapalli P, Moustaid-Moussa NBiochimica et biophysica acta. Molecular and cell biology of lipidsTranscriptomic and microRNA analyses of gene networks regulated by eicosapentaenoic acid in brown adipose tissue of diet-induced obese mice. Biochim Biophys Acta Mol Cell Biol Lipids. 2018 12; 1863(12):1523-1531.Biochim Biophys Acta Mol Cell Biol Lipids2018-09-25T00:00:002018Transcriptomic and microRNA analyses of gene networks regulated by eicosapentaenoic acid in brown adipose tissue of diet-induced obese mice.30407753Mahendra A, Yang X, Abnouf S, Adolacion JRT, Park D, Soomro S, Roszik J, Coarfa C, Romain G, Wanzeck K, Bridges SL, Aggarwal A, Qiu P, Agarwal SK, Mohan C, Varadarajan NArthritis & rheumatology (Hoboken, N.J.)Beyond Autoantibodies: Biologic Roles of Human Autoreactive B Cells in Rheumatoid Arthritis Revealed by RNA-Sequencing. Arthritis Rheumatol. 2019 04; 71(4):529-541.Arthritis Rheumatol2019-02-23T00:00:002019Beyond Autoantibodies: Biologic Roles of Human Autoreactive B Cells in Rheumatoid Arthritis Revealed by RNA-Sequencing.29967256Xing Z, Zhang Y, Liang K, Yan L, Xiang Y, Li C, Hu Q, Jin F, Putluri V, Putluri N, Coarfa C, Sreekumar A, Park PK, Nguyen TK, Wang S, Zhou J, Zhou Y, Marks JR, Hawke DH, Hung MC, Yang L, Han L, Ying H, Lin CCancer researchExpression of Long Noncoding RNA YIYA Promotes Glycolysis in Breast Cancer. Cancer Res. 2018 08 15; 78(16):4524-4532.Cancer Res2018-07-02T00:00:002018Expression of Long Noncoding RNA YIYA Promotes Glycolysis in Breast Cancer.30042831Agarwal S, Milazzo G, Rajapakshe K, Bernardi R, Chen Z, Eveline B, Koster J, Perini G, Coarfa C, Shohet JMOncotargetCorrection: MYCN acts as a direct co-regulator of p53 in MYCN amplified neuroblastoma. Oncotarget. 2018 07 06; 9(52):30024.Oncotarget2018-07-06T00:00:002018Correction: MYCN acts as a direct co-regulator of p53 in MYCN amplified neuroblastoma.30177747Szwarc MM, Kommagani R, Putluri V, Dubrulle J, Stossi F, Mancini MA, Coarfa C, Lanz RB, Putluri N, DeMayo FJ, Lydon JP, O'Malley BWScientific reportsSteroid Receptor Coactivator-2 Controls the Pentose Phosphate Pathway through RPIA in Human Endometrial Cancer Cells. Sci Rep. 2018 09 03; 8(1):13134.Sci Rep2018-09-03T00:00:002018Steroid Receptor Coactivator-2 Controls the Pentose Phosphate Pathway through RPIA in Human Endometrial Cancer Cells.30228349Zhang M, Suarez E, Vasquez JL, Nathanson L, Peterson LE, Rajapakshe K, Basil P, Weigel NL, Coarfa C, Agoulnik IUOncogeneInositol polyphosphate 4-phosphatase type II regulation of androgen receptor activity. Oncogene. 2019 02; 38(7):1121-1135.Oncogene2018-09-18T00:00:002018Inositol polyphosphate 4-phosphatase type II regulation of androgen receptor activity.30739589Cheedipudi SM, Matkovich SJ, Coarfa C, Hu X, Robertson MJ, Sweet M, Taylor M, Mestroni L, Cleveland J, Willerson JT, Gurha P, Marian AJCirculation researchGenomic Reorganization of Lamin-Associated Domains in Cardiac Myocytes Is Associated With Differential Gene Expression and DNA Methylation in Human Dilated Cardiomyopathy. Circ Res. 2019 04 12; 124(8):1198-1213.Circ Res2019-04-12T00:00:002019Genomic Reorganization of Lamin-Associated Domains in Cardiac Myocytes Is Associated With Differential Gene Expression and DNA Methylation in Human Dilated Cardiomyopathy.30575820Saenz DT, Fiskus W, Manshouri T, Mill CP, Qian Y, Raina K, Rajapakshe K, Coarfa C, Soldi R, Bose P, Borthakur G, Kadia TM, Khoury JD, Masarova L, Nowak AJ, Sun B, Saenz DN, Kornblau SM, Horrigan S, Sharma S, Qiu P, Crews CM, Verstovsek S, Bhalla KNLeukemiaTargeting nuclear ?-catenin as therapy for post-myeloproliferative neoplasm secondary AML. Leukemia. 2019 06; 33(6):1373-1386.Leukemia2018-12-21T00:00:002018Targeting nuclear ?-catenin as therapy for post-myeloproliferative neoplasm secondary AML.30647404Fiskus W, Cai T, DiNardo CD, Kornblau SM, Borthakur G, Kadia TM, Pemmaraju N, Bose P, Masarova L, Rajapakshe K, Perera D, Coarfa C, Mill CP, Saenz DT, Saenz DN, Sun B, Khoury JD, Shen Y, Konopleva M, Bhalla KNBlood cancer journalSuperior efficacy of cotreatment with BET protein inhibitor and BCL2 or MCL1 inhibitor against AML blast progenitor cells. Blood Cancer J. 2019 01 15; 9(2):4.Blood Cancer J2019-01-15T00:00:002019Superior efficacy of cotreatment with BET protein inhibitor and BCL2 or MCL1 inhibitor against AML blast progenitor cells.30723176Jiao L, Maity S, Coarfa C, Rajapakshe K, Chen L, Jin F, Putluri V, Tinker LF, Mo Q, Chen F, Sen S, Sangi-Hyghpeykar H, El-Serag HB, Putluri NCancer prevention research (Philadelphia, Pa.)A Prospective Targeted Serum Metabolomics Study of Pancreatic Cancer in Postmenopausal Women. Cancer Prev Res (Phila). 2019 04; 12(4):237-246.Cancer Prev Res (Phila)2019-02-05T00:00:002019A Prospective Targeted Serum Metabolomics Study of Pancreatic Cancer in Postmenopausal Women.30382766Zhang Y, Coarfa C, Dong X, Jiang W, Hayward-Piatkovskyi B, Gleghorn JP, Lingappan KAmerican journal of physiology. Lung cellular and molecular physiologyMicroRNA-30a as a candidate underlying sex-specific differences in neonatal hyperoxic lung injury: implications for BPD. Am J Physiol Lung Cell Mol Physiol. 2019 01 01; 316(1):L144-L156.Am J Physiol Lung Cell Mol Physiol2018-11-01T00:00:002018MicroRNA-30a as a candidate underlying sex-specific differences in neonatal hyperoxic lung injury: implications for BPD.30465315Villanueva H, Grimm SL, Dhamne S, Rajapakshe K, Visbal AP, Davis CM, Ehli EA, Hartig SM, Coarfa C, Edwards DPJournal of mammary gland biology and neoplasiaCorrection to: The Emerging Roles of Steroid Hormone Receptors in Ductal Carcinoma in Situ (DCIS) of the Breast. 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Cell. 2019 01 10; 176(1-2):127-143.e24.Cell2019-01-10T00:00:002019Bacteria-to-Human Protein Networks Reveal Origins of Endogenous DNA Damage.30696354Chen SN, Lombardi R, Karmouch J, Tsai JY, Czernuszewicz G, Taylor MRG, Mestroni L, Coarfa C, Gurha P, Marian AJCirculation researchDNA Damage Response/TP53 Pathway Is Activated and Contributes to the Pathogenesis of Dilated Cardiomyopathy Associated With LMNA (Lamin A/C) Mutations. Circ Res. 2019 03 15; 124(6):856-873.Circ Res2019-03-15T00:00:002019DNA Damage Response/TP53 Pathway Is Activated and Contributes to the Pathogenesis of Dilated Cardiomyopathy Associated With LMNA (Lamin A/C) Mutations.30545964Chen C, Meng Q, Xia Y, Ding C, Wang L, Dai R, Cheng L, Gunaratne P, Gibbs RA, Min S, Coarfa C, Reid JG, Zhang C, Jiao C, Jiang Y, Giase G, Thomas A, Fitzgerald D, Brunetti T, Shieh A, Xia C, Wang Y, Wang Y, Badner JA, Gershon ES, White KP, Liu CScience translational medicineThe transcription factor POU3F2 regulates a gene coexpression network in brain tissue from patients with psychiatric disorders. Sci Transl Med. 2018 12 19; 10(472).Sci Transl Med2018-12-13T00:00:002018The transcription factor POU3F2 regulates a gene coexpression network in brain tissue from patients with psychiatric disorders.30687688Moye LM, Liu Y, Coarfa C, Putluri N, Rhoads JMFrontiers in pediatricsPlasma Urea Cycle Metabolites May Be Useful Biomarkers in Children With Eosinophilic Esophagitis. Front Pediatr. 2018; 6:423.Front Pediatr2019-01-10T00:00:002019Plasma Urea Cycle Metabolites May Be Useful Biomarkers in Children With Eosinophilic Esophagitis.2021-02-28NIHWATERLAND, ROBERT A2017-03-01Epigenetic variation at metastable epialleles: Effects on human obesityR01DK111522Department of Molecular & Cellular BiologyDepartment of Molecular & Human GeneticsMolecular & Cellular BiologyMolecular & Human GeneticsBaylor College of Medicine2.317710.01038881064research areas3.808260.0216272409coauthor of141.96832.660160similar to11291selected publicationsSHIXIAHUANGJaM5+WzGKKv3RYKj5X/XSHIXIA HUANG39.09225730000000-77.20961730000000559HUANG, SHIXIAProfessorQINFENGQIN FENG0.000000000000000.00000000000000699FENG, QINAdjunct Associate ProfessorPAULOVERBEEKPAUL OVERBEEK0.000000000000000.000000000000003122OVERBEEK, PAULProfessor EmeritusDONALDMCDONNELLDONALD MCDONNELL0.000000000000000.000000000000003029MCDONNELL, DONALDAdjunct ProfessorPREETHIGUNARATNEPREETHI GUNARATNE0.000000000000000.000000000000003337GUNARATNE, PREETHIAdjunct Associate ProfessorALEKSANDARMILOSAVLJEVICALEKSANDAR MILOSAVLJEVIC0.000000000000000.00000000000000337MILOSAVLJEVIC, ALEKSANDARProfessorLANLIAOLAN LIAO0.000000000000000.000000000000003430LIAO, LANAssistant ProfessorCo-Principal InvestigatorNAGIREDDYPUTLURINAGIREDDY PUTLURI39.09225730000000-77.209617300000001875PUTLURI, NAGIREDDYProfessorHAKANERIKSSONHAKAN ERIKSSON0.000000000000000.000000000000002317ERIKSSON, HAKANAdjunct ProfessorAuthorship 94135924Authorship 9420015Authorship 9425951430846479Vantaku V, Dong J, Ambati CR, Perera D, Donepudi SR, Amara CS, Putluri V, Ravi SS, Robertson MJ, Piyarathna DWB, Villanueva M, von Rundstedt FC, Karanam B, Ballester LY, Terris MK, Bollag RJ, Lerner SP, Apolo AB, Villanueva H, Lee M, Sikora AG, Lotan Y, Sreekumar A, Coarfa C, Putluri NClinical cancer research : an official journal of the American Association for Cancer ResearchMulti-omics Integration Analysis Robustly Predicts High-Grade Patient Survival and Identifies CPT1B Effect on Fatty Acid Metabolism in Bladder Cancer. Clin Cancer Res. 2019 06 15; 25(12):3689-3701.Clin Cancer Res2019-03-07T00:00:002019Multi-omics Integration Analysis Robustly Predicts High-Grade Patient Survival and Identifies CPT1B Effect on Fatty Acid Metabolism in Bladder Cancer.30002134Koh EH, Chernis N, Saha PK, Xiao L, Bader DA, Zhu B, Rajapakshe K, Hamilton MP, Liu X, Perera D, Chen X, York B, Trauner M, Coarfa C, Bajaj M, Moore DD, Deng T, McGuire SE, Hartig SMDiabetesmiR-30a Remodels Subcutaneous Adipose Tissue Inflammation to Improve Insulin Sensitivity in Obesity. Diabetes. 2018 12; 67(12):2541-2553.Diabetes2018-07-12T00:00:002018miR-30a Remodels Subcutaneous Adipose Tissue Inflammation to Improve Insulin Sensitivity in Obesity.30793158Nomura M, Rainusso N, Lee YC, Dawson B, Coarfa C, Han R, Larson JL, Shuck R, Kurenbekova L, Yustein JTJournal of the National Cancer InstituteTegavivint and the ?-Catenin/ALDH Axis in Chemotherapy-Resistant and Metastatic Osteosarcoma. J Natl Cancer Inst. 2019 11 01; 111(11):1216-1227.J Natl Cancer Inst2019-11-01T00:00:002019Tegavivint and the ?-Catenin/ALDH Axis in Chemotherapy-Resistant and Metastatic Osteosarcoma.Authorship 943618930338425Villanueva H, Grimm S, Dhamne S, Rajapakshe K, Visbal A, Davis CM, Ehli EA, Hartig SM, Coarfa C, Edwards DPJournal of mammary gland biology and neoplasiaThe Emerging Roles of Steroid Hormone Receptors in Ductal Carcinoma in Situ (DCIS) of the Breast. J Mammary Gland Biol Neoplasia. 2018 12; 23(4):237-248.J Mammary Gland Biol Neoplasia2018-10-18T00:00:002018The Emerging Roles of Steroid Hormone Receptors in Ductal Carcinoma in Situ (DCIS) of the Breast.Authorship 944677530953587Marisetty AL, Lu L, Veo BL, Liu B, Coarfa C, Kamal MM, Kassem DH, Irshad K, Lu Y, Gumin J, Henry V, Paulucci-Holthauzen A, Rao G, Baladandayuthapani V, Lang FF, Fuller GN, Majumder SNeuro-oncologyREST-DRD2 mechanism impacts glioblastoma stem cell-mediated tumorigenesis. Neuro Oncol. 2019 06 10; 21(6):775-785.Neuro Oncol2019-06-10T00:00:002019REST-DRD2 mechanism impacts glioblastoma stem cell-mediated tumorigenesis.Authorship 9456538Authorship 9458471831012964Gunaratne PH, Pan Y, Rao AK, Lin C, Hernandez-Herrera A, Liang K, Rait AS, Venkatanarayan A, Benham AL, Rubab F, Kim SS, Rajapakshe K, Chan CK, Mangala LS, Lopez-Berestein G, Sood AK, Rowat AC, Coarfa C, Pirollo KF, Flores ER, Chang EHCancerActivating p53 family member TAp63: A novel therapeutic strategy for targeting p53-altered tumors. Cancer. 2019 07 15; 125(14):2409-2422.Cancer2019-04-23T00:00:002019Activating p53 family member TAp63: A novel therapeutic strategy for targeting p53-altered tumors.31023702Mill CP, Fiskus W, DiNardo CD, Qian Y, Raina K, Rajapakshe K, Perera D, Coarfa C, Kadia TM, Khoury JD, Saenz DT, Saenz DN, Illendula A, Takahashi K, Kornblau SM, Green MR, Futreal AP, Bushweller JH, Crews CM, Bhalla KNBloodRUNX1-targeted therapy for AML expressing somatic or germline mutation in RUNX1. Blood. 2019 07 04; 134(1):59-73.Blood2019-04-25T00:00:002019RUNX1-targeted therapy for AML expressing somatic or germline mutation in RUNX1.Authorship 946382531040347Taneja G, Maity S, Jiang W, Moorthy B, Coarfa C, Ghose RScientific reportsTranscriptomic profiling identifies novel mechanisms of transcriptional regulation of the cytochrome P450 (Cyp)3a11 gene. Sci Rep. 2019 04 30; 9(1):6663.Sci Rep2019-04-30T00:00:002019Transcriptomic profiling identifies novel mechanisms of transcriptional regulation of the cytochrome P450 (Cyp)3a11 gene.Authorship 1262774D059467Concepts & IdeasGenes & Molecular Sequences76218630.524004TranscriptomeAuthorship 1281103Authorship 128793423687340Hsu DM, Agarwal S, Benham A, Coarfa C, Trahan DN, Chen Z, Stowers PN, Courtney AN, Lakoma A, Barbieri E, Metelitsa LS, Gunaratne P, Kim ES, Shohet JMCancer researchG-CSF receptor positive neuroblastoma subpopulations are enriched in chemotherapy-resistant or relapsed tumors and are highly tumorigenic. Cancer Res. 2013 Jul 01; 73(13):4134-46.Cancer Res2013-05-16T00:00:002013G-CSF receptor positive neuroblastoma subpopulations are enriched in chemotherapy-resistant or relapsed tumors and are highly tumorigenic.23791527Seo E, Basu-Roy U, Gunaratne PH, Coarfa C, Lim DS, Basilico C, Mansukhani ACell reportsSOX2 regulates YAP1 to maintain stemness and determine cell fate in the osteo-adipo lineage. Cell Rep. 2013 Jun 27; 3(6):2075-87.Cell Rep2013-06-20T00:00:002013SOX2 regulates YAP1 to maintain stemness and determine cell fate in the osteo-adipo lineage.24040281Tennakoon JB, Wang H, Coarfa C, Cooney AJ, Gunaratne PHPloS oneChromatin changes in dicer-deficient mouse embryonic stem cells in response to retinoic acid induced differentiation. PLoS One. 2013; 8(9):e74556.PLoS One2013-09-09T00:00:002013Chromatin changes in dicer-deficient mouse embryonic stem cells in response to retinoic acid induced differentiation.Authorship 94743014Authorship 94819918Authorship 9482691831112138Yuan X, Chang CY, You R, Shan M, Gu BH, Madison MC, Diehl G, Perusich S, Song LZ, Cornwell L, Rossen RD, Wetsel R, Kimal R, Coarfa C, Eltzschig HK, Corry DB, Kheradmand FJCI insightCigarette smoke-induced reduction of C1q promotes emphysema. JCI Insight. 2019 05 21; 5.JCI Insight2019-05-21T00:00:002019Cigarette smoke-induced reduction of C1q promotes emphysema.31155008Gunasekara CJ, Scott CA, Laritsky E, Baker MS, MacKay H, Duryea JD, Kessler NJ, Hellenthal G, Wood AC, Hodges KR, Gandhi M, Hair AB, Silver MJ, Moore SE, Prentice AM, Li Y, Chen R, Coarfa C, Waterland RAGenome biologyA genomic atlas of systemic interindividual epigenetic variation in humans. Genome Biol. 2019 06 03; 20(1):105.Genome Biol2019-06-03T00:00:002019A genomic atlas of systemic interindividual epigenetic variation in humans.31160797Hu Q, Ye Y, Chan LC, Li Y, Liang K, Lin A, Egranov SD, Zhang Y, Xia W, Gong J, Pan Y, Chatterjee SS, Yao J, Evans KW, Nguyen TK, Park PK, Liu J, Coarfa C, Donepudi SR, Putluri V, Putluri N, Sreekumar A, Ambati CR, Hawke DH, Marks JR, Gunaratne PH, Caudle AS, Sahin AA, Hortobagyi GN, Meric-Bernstam F, Chen L, Yu D, Hung MC, Curran MA, Han L, Lin C, Yang LNature immunologyOncogenic lncRNA downregulates cancer cell antigen presentation and intrinsic tumor suppression. Nat Immunol. 2019 07; 20(7):835-851.Nat Immunol2019-06-03T00:00:002019Oncogenic lncRNA downregulates cancer cell antigen presentation and intrinsic tumor suppression.Authorship 94910414Authorship 9491681931198906Bader DA, Hartig SM, Putluri V, Foley C, Hamilton MP, Smith EA, Saha PK, Panigrahi A, Walker C, Zong L, Martini-Stoica H, Chen R, Rajapakshe K, Coarfa C, Sreekumar A, Mitsiades N, Bankson JA, Ittmann MM, O'Malley BW, Putluri N, McGuire SENature metabolismMitochondrial pyruvate import is a metabolic vulnerability in androgen receptor-driven prostate cancer. Nat Metab. 2019 01; 1(1):70-85.Nat Metab2018-11-19T00:00:002018Mitochondrial pyruvate import is a metabolic vulnerability in androgen receptor-driven prostate cancer.31201419Lu Y, Oura S, Matsumura T, Oji A, Sakurai N, Fujihara Y, Shimada K, Miyata H, Tobita T, Noda T, Castaneda JM, Kiyozumi D, Zhang Q, Larasati T, Young SAM, Kodani M, Huddleston CA, Robertson MJ, Coarfa C, Isotani A, Aitken RJ, Okabe M, Matzuk MM, Garcia TX, Ikawa MBiology of reproductionCRISPR/Cas9-mediated genome editing reveals 30 testis-enriched genes dispensable for male fertility in mice?. Biol Reprod. 2019 08 01; 101(2):501-511.Biol Reprod2019-08-01T00:00:002019CRISPR/Cas9-mediated genome editing reveals 30 testis-enriched genes dispensable for male fertility in mice?.Authorship 9497316Authorship 950076331208719Suter MA, Aagaard KM, Coarfa C, Robertson M, Zhou G, Jackson BP, Thompson D, Putluri V, Putluri N, Hagan J, Wang L, Jiang W, Lingappan K, Moorthy BBiochemical and biophysical research communicationsAssociation between elevated placental polycyclic aromatic hydrocarbons (PAHs) and PAH-DNA adducts from Superfund sites in Harris County, and increased risk of preterm birth (PTB). 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Cytokine. 2019 11; 123:154745.Cytokine2019-06-18T00:00:002019Short-term RANKL exposure initiates a neoplastic transcriptional program in the basal epithelium of the murine salivary gland.Authorship 9518561731284295Vantaku V, Amara CS, Piyarathna DWB, Donepudi SR, Ambati CR, Putluri V, Tang W, Rajapakshe K, Estecio MR, Terris MK, Castro PD, Ittmann MM, Williams SB, Lerner SP, Sreekumar A, Bollag R, Coarfa C, Kornberg MD, Lotan Y, Ambs S, Putluri NCarcinogenesisDNA methylation patterns in bladder tumors of African American patients point to distinct alterations in xenobiotic metabolism. Carcinogenesis. 2019 11 25; 40(11):1332-1340.Carcinogenesis2019-11-25T00:00:002019DNA methylation patterns in bladder tumors of African American patients point to distinct alterations in xenobiotic metabolism.Authorship 952709831350552Cheedipudi SM, Hu J, Fan S, Yuan P, Karmouch J, Czernuszewicz G, Robertson MJ, Coarfa C, Hong K, Yao Y, Campbell H, Wehrens X, Gurha P, Marian AJCardiovascular researchExercise restores dysregulated gene expression in a mouse model of arrhythmogenic cardiomyopathy. Cardiovasc Res. 2020 05 01; 116(6):1199-1213.Cardiovasc Res2020-05-01T00:00:002020Exercise restores dysregulated gene expression in a mouse model of arrhythmogenic cardiomyopathy.Authorship 952869431356139Fan Q, Mao H, Angelini A, Coarfa C, Robertson MJ, Lagor WR, Wehrens XHT, Martin JF, Pi X, Xie LCirculationDepletion of Endothelial Prolyl Hydroxylase Domain Protein 2 and 3 Promotes Cardiomyocyte Proliferation and Prevents Ventricular Failure Induced by Myocardial Infarction. Circulation. 2019 07 30; 140(5):440-442.Circulation2019-07-29T00:00:002019Depletion of Endothelial Prolyl Hydroxylase Domain Protein 2 and 3 Promotes Cardiomyocyte Proliferation and Prevents Ventricular Failure Induced by Myocardial Infarction.Authorship 9533091631383940Vantaku V, Putluri V, Bader DA, Maity S, Ma J, Arnold JM, Rajapakshe K, Donepudi SR, von Rundstedt FC, Devarakonda V, Dubrulle J, Karanam B, McGuire SE, Stossi F, Jain AK, Coarfa C, Cao Q, Sikora AG, Villanueva H, Kavuri SM, Lotan Y, Sreekumar A, Putluri NOncogeneEpigenetic loss of AOX1 expression via EZH2 leads to metabolic deregulations and promotes bladder cancer progression. 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Cancer Res. 2019 Sep 01; 79(17):4552.Cancer Res2019-09-01T00:00:002019Correction: Androgen Receptor Is the Key Transcriptional Mediator of the Tumor Suppressor SPOP in Prostate Cancer.31474581Piyarathna DWB, Rajendiran TM, Putluri V, Vantaku V, Soni T, von Rundstedt FC, Donepudi SR, Jin F, Maity S, Ambati CR, Dong J, G?dde D, Roth S, St?rkel S, Degener S, Michailidis G, Lerner SP, Pennathur S, Lotan Y, Coarfa C, Sreekumar A, Putluri NEuropean urology focusErratum to "Distinct Lipidomic Landscapes Associated with Clinical Stages of Urothelial Cancer of the Bladder" [Eur Urol Focus 2018;4:907-915]. Eur Urol Focus. 2019 Sep; 5(5):920.Eur Urol Focus2019-08-30T00:00:002019Erratum to "Distinct Lipidomic Landscapes Associated with Clinical Stages of Urothelial Cancer of the Bladder" [Eur Urol Focus 2018;4:907-915].Authorship 1079625true1Professor EmeritusProfessor EmeritusAuthorship 960715631704792Rodriguez A, Briley SM, Patton BK, Tripurani SK, Rajapakshe K, Coarfa C, Rajkovic A, Andrieux A, Dejean A, Pangas SADevelopment (Cambridge, England)Loss of the E2 SUMO-conjugating enzyme Ube2i in oocytes during ovarian folliculogenesis causes infertility in mice. Development. 2019 12 02; 146(23).Development2019-12-02T00:00:002019Loss of the E2 SUMO-conjugating enzyme Ube2i in oocytes during ovarian folliculogenesis causes infertility in mice.Authorship 9620211131792207MacKay H, Scott CA, Duryea JD, Baker MS, Laritsky E, Elson AE, Garland T, Fiorotto ML, Chen R, Li Y, Coarfa C, Simerly RB, Waterland RANature communicationsDNA methylation in AgRP neurons regulates voluntary exercise behavior in mice. Nat Commun. 2019 12 02; 10(1):5364.Nat Commun2019-12-02T00:00:002019DNA methylation in AgRP neurons regulates voluntary exercise behavior in mice.Authorship 9624678Authorship 962550831827727Vantaku V, Donepudi SR, Ambati CR, Jin F, Putluri V, Nguyen K, Rajapakshe K, Coarfa C, Battula VL, Lotan Y, Putluri NOncotargetCorrection: Expression of ganglioside GD2, reprogram the lipid metabolism and EMT phenotype in bladder cancer. 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Environ Health Perspect. 2020 01; 128(1):17010.Environ Health Perspect2020-01-15T00:00:002020Hepatic Tumor Formation in Adult Mice Developmentally Exposed to Organotin.31941830Corn PG, Zhang M, Nogueras-Gonzalez GM, Xiao L, Zurita AJ, Subudhi SK, Tu SM, Aparicio AM, Coarfa C, Rajapakshe K, Huang S, Navone NM, Lin SH, Wang G, Ramachandran S, Titus MA, Panaretakis T, Gallick GE, Efstathiou E, Troncoso P, Logothetis CClinical cancer research : an official journal of the American Association for Cancer ResearchA Phase II Study of Cabozantinib and Androgen Ablation in Patients with Hormone-Na?ve Metastatic Prostate Cancer. 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Nat Commun. 2020 05 08; 11(1):2316.Nat Commun2020-05-08T00:00:002020Epigenome environment interactions accelerate epigenomic aging and unlock metabolically restricted epigenetic reprogramming in adulthood.Authorship 989457532408067da Silva Teixeira S, Harrison K, Uzodike M, Rajapakshe K, Coarfa C, He Y, Xu Y, Sisley SThe Journal of steroid biochemistry and molecular biologyVitamin D actions in neurons require the PI3K pathway for both enhancing insulin signaling and rapid depolarizing effects. J Steroid Biochem Mol Biol. 2020 06; 200:105690.J Steroid Biochem Mol Biol2020-05-11T00:00:002020Vitamin D actions in neurons require the PI3K pathway for both enhancing insulin signaling and rapid depolarizing effects.Authorship 990854432484798Auguste G, Rouhi L, Matkovich SJ, Coarfa C, Robertson MJ, Czernuszewicz G, Gurha P, Marian AJThe Journal of clinical investigationBET bromodomain inhibition attenuates cardiac phenotype in myocyte-specific lamin A/C-deficient mice. 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Endocrinology and metabolismmiR-30a targets gene networks that promote browning of human and mouse adipocytes. Am J Physiol Endocrinol Metab. 2020 10 01; 319(4):E667-E677.Am J Physiol Endocrinol Metab2020-08-17T00:00:002020miR-30a targets gene networks that promote browning of human and mouse adipocytes.Authorship 9992461232907944Lin SC, Qu L, Ettayebi K, Crawford SE, Blutt SE, Robertson MJ, Zeng XL, Tenge VR, Ayyar BV, Karandikar UC, Yu X, Coarfa C, Atmar RL, Ramani S, Estes MKProceedings of the National Academy of Sciences of the United States of AmericaHuman norovirus exhibits strain-specific sensitivity to host interferon pathways in human intestinal enteroids. Proc Natl Acad Sci U S A. 2020 09 22; 117(38):23782-23793.Proc Natl Acad Sci U S A2020-09-09T00:00:002020Human norovirus exhibits strain-specific sensitivity to host interferon pathways in human intestinal enteroids.Authorship 999935132961439Coarfa C, Grimm SL, Katz T, Zhang Y, Jangid RK, Walker CL, Moorthy B, Lingappan KRedox biologyEpigenetic response to hyperoxia in the neonatal lung is sexually dimorphic. Redox Biol. 2020 10; 37:101718.Redox Biol2020-09-11T00:00:002020Epigenetic response to hyperoxia in the neonatal lung is sexually dimorphic.Authorship 100101318Authorship 10010731532986782Rajan A, Robertson MJ, Carter HE, Poole NM, Clark JR, Green SI, Criss ZK, Zhao B, Karandikar U, Xing Y, Margalef-Catal? 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Diabetes. 2020 12; 69(12):2630-2641.Diabetes2020-09-29T00:00:002020STAT1 Dissociates Adipose Tissue Inflammation From Insulin Sensitivity in Obesity.Authorship 1001973533036756Seervai RNH, Grimm SL, Jangid RK, Tripathi DN, Coarfa C, Walker CLBiochemical and biophysical research communicationsAn actin-WHAMM interaction linking SETD2 and autophagy. Biochem Biophys Res Commun. 2021 06 18; 558:202-208.Biochem Biophys Res Commun2020-10-06T00:00:002020An actin-WHAMM interaction linking SETD2 and autophagy.Authorship 100285211Authorship 1002855733056990Napoli M, Li X, Ackerman HD, Deshpande AA, Barannikov I, Pisegna MA, Bedrosian I, Mitsch J, Quinlan P, Thompson A, Rajapakshe K, Coarfa C, Gunaratne PH, Marchion DC, Magliocco AM, Tsai KY, Flores ERNature communicationsPan-cancer analysis reveals TAp63-regulated oncogenic lncRNAs that promote cancer progression through AKT activation. Nat Commun. 2020 10 14; 11(1):5156.Nat Commun2020-10-14T00:00:002020Pan-cancer analysis reveals TAp63-regulated oncogenic lncRNAs that promote cancer progression through AKT activation.33057049Nguyen TN, Rajapakshe K, Nicholas C, Tordesillas L, Ehli EA, Davis CM, Coarfa C, Flores ER, Dickinson SE, Curiel-Lewandrowski C, Tsai KYScientific reportsIntegrative transcriptomic analysis for linking acute stress responses to squamous cell carcinoma development. Sci Rep. 2020 10 14; 10(1):17209.Sci Rep2020-10-14T00:00:002020Integrative transcriptomic analysis for linking acute stress responses to squamous cell carcinoma development.Authorship 1003028733070193Rouhi L, Cheedipudi SM, Chen SN, Fan S, Lombardi R, Chen X, Coarfa C, Robertson MJ, Gurha P, Marian AJCardiovascular researchHaploinsufficiency of Tmem43 in cardiac myocytes activates the DNA damage response pathway leading to a late-onset senescence-associated pro-fibrotic cardiomyopathy. Cardiovasc Res. 2021 09 28; 117(11):2377-2394.Cardiovasc Res2021-09-28T00:00:002021Haploinsufficiency of Tmem43 in cardiac myocytes activates the DNA damage response pathway leading to a late-onset senescence-associated pro-fibrotic cardiomyopathy.true1Adjunct ProfessorAdjunct Professortrue1Adjunct ProfessorAdjunct ProfessorAuthorship 10047531133168646Dasgupta A, Sierra L, Tsang SV, Kurenbekova L, Patel T, Rajapakse K, Shuck RL, Rainusso N, Landesman Y, Unger T, Coarfa C, Yustein JTCancer researchTargeting PAK4 Inhibits Ras-Mediated Signaling and Multiple Oncogenic Pathways in High-Risk Rhabdomyosarcoma. Cancer Res. 2021 01 01; 81(1):199-212.Cancer Res2020-11-09T00:00:002020Targeting PAK4 Inhibits Ras-Mediated Signaling and Multiple Oncogenic Pathways in High-Risk Rhabdomyosarcoma.Authorship 1006154933257837Dustin D, Gu G, Beyer AR, Herzog SK, Edwards DG, Lin H, Gonzalez TL, Grimm SL, Coarfa C, Chan DW, Kim BJ, De La O JP, Ellis MJ, Liu D, Li S, Welm AL, Fuqua SAWBritish journal of cancerRON signalling promotes therapeutic resistance in ESR1 mutant breast cancer. Br J Cancer. 2021 01; 124(1):191-206.Br J Cancer2020-12-01T00:00:002020RON signalling promotes therapeutic resistance in ESR1 mutant breast cancer.Authorship 10066835Authorship 10067331033300995Nagandla H, Robertson MJ, Putluri V, Putluri N, Coarfa C, Weigel NLEndocrinologyIsoform-specific Activities of Androgen Receptor and its Splice Variants in Prostate Cancer Cells. Endocrinology. 2021 03 01; 162(3).Endocrinology2021-03-01T00:00:002021Isoform-specific Activities of Androgen Receptor and its Splice Variants in Prostate Cancer Cells.33305154Preidis GA, Soni KG, Suh JH, Halder T, Kim KH, Choi JM, Li F, Devaraj S, Conner ME, Coarfa C, Jung SY, Moore DDHepatology communicationsCoagulopathy in Malnourished Mice Is Sexually Dimorphic and Regulated by Nutrient-Sensing Nuclear Receptors. Hepatol Commun. 2020 Dec; 4(12):1835-1850.Hepatol Commun2020-10-22T00:00:002020Coagulopathy in Malnourished Mice Is Sexually Dimorphic and Regulated by Nutrient-Sensing Nuclear Receptors.Authorship 10069552733323970Gu G, Tian L, Herzog SK, Rechoum Y, Gelsomino L, Gao M, Du L, Kim JA, Dustin D, Lo HC, Beyer AR, Edwards DG, Gonzalez T, Tsimelzon A, Huang HJ, Fernandez NM, Grimm SL, Hilsenbeck SG, Liu D, Xu J, Alaniz A, Li S, Mills GB, Janku F, Kittler R, Zhang XH, Coarfa C, Foulds CE, Symmans WF, And? S, Fuqua SAWOncogeneHormonal modulation of ESR1 mutant metastasis. Oncogene. 2021 02; 40(5):997-1011.Oncogene2020-12-15T00:00:002020Hormonal modulation of ESR1 mutant metastasis.33414491Qasim SL, Sierra L, Shuck R, Kurenbekova L, Patel TD, Rajapakshe K, Wulff J, Nakahata K, Kim HR, Landesman Y, Unger TJ, Coarfa C, Yustein JTOncogenep21-activated kinases as viable therapeutic targets for the treatment of high-risk Ewing sarcoma. Oncogene. 2021 02; 40(6):1176-1190.Oncogene2021-01-07T00:00:002021p21-activated kinases as viable therapeutic targets for the treatment of high-risk Ewing sarcoma.Authorship 100842812Authorship 1008850533446905Rana M, Dong J, Robertson MJ, Basil P, Coarfa C, Weigel NLScientific reportsAndrogen receptor and its splice variant, AR-V7, differentially induce mRNA splicing in prostate cancer cells. Sci Rep. 2021 01 14; 11(1):1393.Sci Rep2021-01-14T00:00:002021Androgen receptor and its splice variant, AR-V7, differentially induce mRNA splicing in prostate cancer cells.Authorship 1133417Authorship 1009549933470189Shneider BL, Cortes-Santiago N, Schady DA, Krishnamoorthy S, Thevananther S, Rajapakshe K, Perera D, Huang S, Coarfa CAmerican journal of physiology. Gastrointestinal and liver physiologyConstitutive activation of mitogen-activated protein kinase kinase (MEK1) in ileal enterocytes leads to dysplasia and a predisposition to cancer. Am J Physiol Gastrointest Liver Physiol. 2021 03 01; 320(3):G366-G379.Am J Physiol Gastrointest Liver Physiol2021-01-20T00:00:002021Constitutive activation of mitogen-activated protein kinase kinase (MEK1) in ileal enterocytes leads to dysplasia and a predisposition to cancer.Authorship 10115101Authorship 10126499Authorship 10126571433584151Coarfa C, Grimm SL, Rajapakshe K, Perera D, Lu HY, Wang X, Christensen KR, Mo Q, Edwards DP, Huang SJournal of biomolecular techniques : JBTReverse-Phase Protein Array: Technology, Application, Data Processing, and Integration. J Biomol Tech. 2021 Jan 15.J Biomol Tech2021-01-15T00:00:002021Reverse-Phase Protein Array: Technology, Application, Data Processing, and Integration.33654130Jain PN, Robertson M, Lasa JJ, Shekerdemian L, Guffey D, Zhang Y, Lingappan K, Checchia P, Coarfa CScientific reportsAltered metabolic and inflammatory transcriptomics after cardiac surgery in neonates with congenital heart disease. Sci Rep. 2021 03 02; 11(1):4965.Sci Rep2021-03-02T00:00:002021Altered metabolic and inflammatory transcriptomics after cardiac surgery in neonates with congenital heart disease.33654205Fiskus W, Mill CP, Perera D, Birdwell C, Deng Q, Yang H, Lara BH, Jain N, Burger J, Ferrajoli A, Davis JA, Saenz DT, Jin W, Coarfa C, Crews CM, Green MR, Khoury JD, Bhalla KNLeukemiaBET proteolysis targeted chimera-based therapy of novel models of Richter Transformation-diffuse large B-cell lymphoma. Leukemia. 2021 09; 35(9):2621-2634.Leukemia2021-03-02T00:00:002021BET proteolysis targeted chimera-based therapy of novel models of Richter Transformation-diffuse large B-cell lymphoma.Authorship 10146261333771853Hegde A, Jayaprakash P, Couillault CA, Piha-Paul S, Karp D, Rodon J, Pant S, Fu S, Dumbrava EE, Yap TA, Subbiah V, Bhosale P, Coarfa C, Higgins JP, Williams ET, Wilson TF, Lim J, Meric-Bernstam F, Sumner E, Zain H, Nguyen D, Nguyen LM, Rajapakshe K, Curran MA, Hong DSClinical cancer research : an official journal of the American Association for Cancer ResearchA Phase I Dose-Escalation Study to Evaluate the Safety and Tolerability of Evofosfamide in Combination with Ipilimumab in Advanced Solid Malignancies. Clin Cancer Res. 2021 06 01; 27(11):3050-3060.Clin Cancer Res2021-03-26T00:00:002021A Phase I Dose-Escalation Study to Evaluate the Safety and Tolerability of Evofosfamide in Combination with Ipilimumab in Advanced Solid Malignancies.Authorship 10158381033811077Karki M, Jangid RK, Anish R, Seervai RNH, Bertocchio JP, Hotta T, Msaouel P, Jung SY, Grimm SL, Coarfa C, Weissman BE, Ohi R, Verhey KJ, Hodges HC, Burggren W, Dere R, Park IY, Prasad BVV, Rathmell WK, Walker CL, Tripathi DNScience advancesA cytoskeletal function for PBRM1 reading methylated microtubules. Sci Adv. 2021 04; 7(14).Sci Adv2021-04-02T00:00:002021A cytoskeletal function for PBRM1 reading methylated microtubules.Authorship 10169301133893071Dittmar RL, Liu S, Tai MC, Rajapakshe K, Huang Y, Longton G, DeCapite C, Hurd MW, Paris PL, Kirkwood KS, Coarfa C, Maitra A, Brand RE, Killary AM, Sen SCancer prevention research (Philadelphia, Pa.)Plasma miRNA Biomarkers in Limited Volume Samples for Detection of Early-stage Pancreatic Cancer. Cancer Prev Res (Phila). 2021 07; 14(7):729-740.Cancer Prev Res (Phila)2021-04-23T00:00:002021Plasma miRNA Biomarkers in Limited Volume Samples for Detection of Early-stage Pancreatic Cancer.Authorship 1018299533976356Rana M, Dong J, Robertson MJ, Basil P, Coarfa C, Weigel NLScientific reportsAuthor Correction: Androgen receptor and its splice variant, AR-V7, differentially induce mRNA splicing in prostate cancer cells. Sci Rep. 2021 May 11; 11(1):10437.Sci Rep2021-05-11T00:00:002021Author Correction: Androgen receptor and its splice variant, AR-V7, differentially induce mRNA splicing in prostate cancer cells.Authorship 101864613Authorship 101897310Authorship 10190122334014281Koenning M, Wang X, Karki M, Jangid RK, Kearns S, Tripathi DN, Cianfrocco M, Verhey KJ, Jung SY, Coarfa C, Ward CS, Kalish BT, Grimm SL, Rathmell WK, Mostany R, Dere R, Rasband MN, Walker CL, Park IYBrain : a journal of neurologyNeuronal SETD2 activity links microtubule methylation to an anxiety-like phenotype in mice. Brain. 2021 09 04; 144(8):2527-2540.Brain2021-09-04T00:00:002021Neuronal SETD2 activity links microtubule methylation to an anxiety-like phenotype in mice.34016956Fiskus W, Mill CP, Nabet B, Perera D, Birdwell C, Manshouri T, Lara B, Kadia TM, DiNardo C, Takahashi K, Daver N, Bose P, Masarova L, Pemmaraju N, Kornblau S, Borthakur G, Montalban-Bravo G, Manero GG, Sharma S, Stubbs M, Su X, Green MR, Coarfa C, Verstovsek S, Khoury JD, Vakoc CR, Bhalla KNBlood cancer journalSuperior efficacy of co-targeting GFI1/KDM1A and BRD4 against AML and post-MPN secondary AML cells. Blood Cancer J. 2021 05 20; 11(5):98.Blood Cancer J2021-05-20T00:00:002021Superior efficacy of co-targeting GFI1/KDM1A and BRD4 against AML and post-MPN secondary AML cells.33991687Napierala JS, Rajapakshe K, Clark A, Chen YY, Huang S, Mesaros C, Xu P, Blair IA, Hauser LA, Farmer J, Lynch DR, Edwards DP, Coarfa C, Napierala MMolecular & cellular proteomics : MCPReverse Phase Protein Array Reveals Correlation of Retinoic Acid Metabolism With Cardiomyopathy in Friedreich's Ataxia. Mol Cell Proteomics. 2021; 20:100094.Mol Cell Proteomics2021-05-13T00:00:002021Reverse Phase Protein Array Reveals Correlation of Retinoic Acid Metabolism With Cardiomyopathy in Friedreich's Ataxia.34002003Chowdhury P, Perera D, Powell RT, Talley T, Tripathi DN, Park YS, Mancini MA, Davies P, Stephan C, Coarfa C, Dere RScientific reportsTherapeutically actionable signaling node to rescue AURKA driven loss of primary cilia in VHL-deficient cells. Sci Rep. 2021 05 17; 11(1):10461.Sci Rep2021-05-17T00:00:002021Therapeutically actionable signaling node to rescue AURKA driven loss of primary cilia in VHL-deficient cells.Authorship 10192501Authorship 1019423334039674Kontsevaya I, Lange C, Comella-Del-Barrio P, Coarfa C, DiNardo AR, Gillespie SH, Hauptmann M, Leschczyk C, Mandalakas AM, Martinecz A, Merker M, Niemann S, Reimann M, Rzhepishevska O, Schaible UE, Scheu KM, Schurr E, Abel Zur Wiesch P, Heyckendorf JEuropean respiratory review : an official journal of the European Respiratory SocietyPerspectives for systems biology in the management of tuberculosis. Eur Respir Rev. 2021 Jun 30; 30(160).Eur Respir Rev2021-05-25T00:00:002021Perspectives for systems biology in the management of tuberculosis.34025221Coarfa C, Grimm SL, Rajapakshe K, Perera D, Lu HY, Wang X, Christensen KR, Mo Q, Edwards DP, Huang SJournal of biomolecular techniques : JBTReverse-Phase Protein Array: Technology, Application, Data Processing, and Integration. J Biomol Tech. 2021 04; 32(1):15-29.J Biomol Tech2021-04-01T00:00:002021Reverse-Phase Protein Array: Technology, Application, Data Processing, and Integration.Authorship 1020067734061778Grimm SL, Dong X, Zhang Y, Carisey AF, Arnold AP, Moorthy B, Coarfa C, Lingappan KJCI insightEffect of sex chromosomes versus hormones in neonatal lung injury. JCI Insight. 2021 07 08; 6(13).JCI Insight2021-07-08T00:00:002021Effect of sex chromosomes versus hormones in neonatal lung injury.Authorship 10206391634099494Yue F, Jiang W, Ku AT, Young AIJ, Zhang W, Souto EP, Gao Y, Yu Z, Wang Y, Creighton CJ, Nagi C, Wang T, Hilsenbeck SG, Feng XH, Huang S, Coarfa C, Zhang XH, Liu Q, Lin X, Li YCancer researchA Wnt-Independent LGR4-EGFR Signaling Axis in Cancer Metastasis. Cancer Res. 2021 09 01; 81(17):4441-4454.Cancer Res2021-06-07T00:00:002021A Wnt-Independent LGR4-EGFR Signaling Axis in Cancer Metastasis.Authorship 10212566Authorship 1021283634132777Rouhi L, Fan S, Cheedipudi SM, Braza-Bo?ls A, Molina MS, Yao Y, Robertson MJ, Coarfa C, Gimeno JR, Molina P, Gurha P, Zorio E, Marian AJCardiovascular researchThe EP300/TP53 pathway, a suppressor of the Hippo and canonical WNT pathways, is activated in human hearts with arrhythmogenic cardiomyopathy in the absence of overt heart failure. Cardiovasc Res. 2022 05 06; 118(6):1466-1478.Cardiovasc Res2022-05-06T00:00:002022The EP300/TP53 pathway, a suppressor of the Hippo and canonical WNT pathways, is activated in human hearts with arrhythmogenic cardiomyopathy in the absence of overt heart failure.34134789Noel CV, Rainusso N, Robertson M, Romero J, Masand P, Coarfa C, Pautler RCardio-oncology (London, England)Early detection of myocardial changes with and without dexrazoxane using serial magnetic resonance imaging in a pre-clinical mouse model. Cardiooncology. 2021 Jun 16; 7(1):23.Cardiooncology2021-06-16T00:00:002021Early detection of myocardial changes with and without dexrazoxane using serial magnetic resonance imaging in a pre-clinical mouse model.https://www.bcm.edu/research/research-services/atc-core-labs/antibody-based-proteomicsAntibody-based Proteomics Corehttps://www.bcm.edu/academic-centers/dan-l-duncan-comprehensive-cancer-center/research/cancer-shared-resources/reverse-phase-protein-arrayReverse Phase Protein ArrayAuthorship 10251131634262645Hebert KA, Jaramillo S, Yu W, Wang M, Veeramachaneni R, Sandulache VC, Sikora AG, Bonnen MD, Annapragada AV, Corry D, Kheradmand F, Pandita RK, Ludwig MS, Pandita TK, Huang S, Coarfa C, Grimm SL, Perera D, Miles G, Ghebre YTOncotargetEsomeprazole enhances the effect of ionizing radiation to improve tumor control. Oncotarget. 2021 Jul 06; 12(14):1339-1353.Oncotarget2021-07-06T00:00:002021Esomeprazole enhances the effect of ionizing radiation to improve tumor control.Authorship 10256309Authorship 1025798734280559Swaminathan G, Kamyabi N, Carter HE, Rajan A, Karandikar U, Criss ZK, Shroyer NF, Robertson MJ, Coarfa C, Huang C, Shannon TE, Tadros M, Estes MK, Maresso AW, Grande-Allen KJActa biomaterialiaEffect of substrate stiffness on human intestinal enteroids' infectivity by enteroaggregative Escherichia coli. Acta Biomater. 2021 09 15; 132:245-259.Acta Biomater2021-07-17T00:00:002021Effect of substrate stiffness on human intestinal enteroids' infectivity by enteroaggregative Escherichia coli.34288725Blutt SE, Crawford SE, Bomidi C, Zeng XL, Broughman JR, Robertson M, Coarfa C, Tessier MEM, Savidge T, Hollinger FB, Curley SA, Donowitz M, Estes MKAmerican journal of physiology. Gastrointestinal and liver physiologyUse of human tissue stem cell-derived organoid cultures to model enterohepatic circulation. Am J Physiol Gastrointest Liver Physiol. 2021 09 01; 321(3):G270-G279.Am J Physiol Gastrointest Liver Physiol2021-07-21T00:00:002021Use of human tissue stem cell-derived organoid cultures to model enterohepatic circulation.Authorship 102682320Authorship 102711312Authorship 1027121434341132Ager CR, Boda A, Rajapakshe K, Lea ST, Di Francesco ME, Jayaprakash P, Slay RB, Morrow B, Prasad R, Dean MA, Duffy CR, Coarfa C, Jones P, Curran MAJournal for immunotherapy of cancerHigh potency STING agonists engage unique myeloid pathways to reverse pancreatic cancer immune privilege. J Immunother Cancer. 2021 08; 9(8).J Immunother Cancer2021-08-01T00:00:002021High potency STING agonists engage unique myeloid pathways to reverse pancreatic cancer immune privilege.34341337Gunasekara CJ, Hannon E, MacKay H, Coarfa C, McQuillin A, Clair DS, Mill J, Waterland RATranslational psychiatryA machine learning case-control classifier for schizophrenia based on DNA methylation in blood. Transl Psychiatry. 2021 08 03; 11(1):412.Transl Psychiatry2021-08-03T00:00:002021A machine learning case-control classifier for schizophrenia based on DNA methylation in blood.34353949Li Y, Tan Z, Zhang Y, Zhang Z, Hu Q, Liang K, Jun Y, Ye Y, Li YC, Li C, Liao L, Xu J, Xing Z, Pan Y, Chatterjee SS, Nguyen TK, Hsiao H, Egranov SD, Putluri N, Coarfa C, Hawke DH, Gunaratne PH, Tsai KL, Han L, Hung MC, Calin GA, Namour F, Gu?ant JL, Muntau AC, Blau N, Sutton VR, Schiff M, Feillet F, Zhang S, Lin C, Yang LScience (New York, N.Y.)A noncoding RNA modulator potentiates phenylalanine metabolism in mice. Science. 2021 08 06; 373(6555):662-673.Science2021-08-06T00:00:002021A noncoding RNA modulator potentiates phenylalanine metabolism in mice.Authorship 10273296Authorship 10273381634365017Anvari S, Watkin L, Rajapakshe K, Hassan O, Schuster K, Coarfa C, Davis CMClinical immunology (Orlando, Fla.)Memory and na?ve gamma delta regulatory T-cell gene expression in the first 24-weeks of peanut oral immunotherapy. Clin Immunol. 2021 09; 230:108820.Clin Immunol2021-08-06T00:00:002021Memory and na?ve gamma delta regulatory T-cell gene expression in the first 24-weeks of peanut oral immunotherapy.34365742Tao L, Moreno-Smith M, Ibarra-Garc?a-Padilla R, Milazzo G, Drolet NA, Hernandez BE, Oh YS, Patel I, Kim JJ, Zorman B, Patel T, Kamal AHM, Zhao Y, Hicks J, Vasudevan SA, Putluri N, Coarfa C, Sumazin P, Perini G, Parchem RJ, Uribe RA, Barbieri EAdvanced science (Weinheim, Baden-Wurttemberg, Germany)CHAF1A Blocks Neuronal Differentiation and Promotes Neuroblastoma Oncogenesis via Metabolic Reprogramming. Adv Sci (Weinh). 2021 10; 8(19):e2005047.Adv Sci (Weinh)2021-08-08T00:00:002021CHAF1A Blocks Neuronal Differentiation and Promotes Neuroblastoma Oncogenesis via Metabolic Reprogramming.true1Associate ProfessorAssociate Professor2Associate ProfessorAssociate ProfessorAuthorship 102879110Authorship 10289961034462545Chowdhury P, Perera D, Powell RT, Talley T, Tripathi DN, Park YS, Mancini MA, Davies P, Stephan C, Coarfa C, Dere RScientific reportsAuthor Correction: Therapeutically actionable signaling node to rescue AURKA driven loss of primary cilia in VHL-deficient cells. Sci Rep. 2021 Aug 30; 11(1):17657.Sci Rep2021-08-30T00:00:002021Author Correction: Therapeutically actionable signaling node to rescue AURKA driven loss of primary cilia in VHL-deficient cells.Authorship 1029228634489478Mao H, Li L, Fan Q, Angelini A, Saha PK, Coarfa C, Rajapakshe K, Perera D, Cheng J, Wu H, Ballantyne CM, Sun Z, Xie L, Pi XNature communicationsEndothelium-specific depletion of LRP1 improves glucose homeostasis through inducing osteocalcin. Nat Commun. 2021 09 06; 12(1):5296.Nat Commun2021-09-06T00:00:002021Endothelium-specific depletion of LRP1 improves glucose homeostasis through inducing osteocalcin.SANDRAGRIMMSANDRA GRIMM17188GRIMM, SANDRAAssistant ProfessorAuthorship 10314161834636746Kaochar S, Rusin A, Foley C, Rajapakshe K, Robertson M, Skapura D, Mason C, Berman De Ruiz K, Tyryshkin AM, Deng J, Shin JN, Fiskus W, Dong J, Huang S, Navone NM, Davis CM, Ehli EA, Coarfa C, Mitsiades NEndocrine-related cancerInhibition of GATA2 in prostate cancer by a clinically available small molecule. Endocr Relat Cancer. 2021 11 24; 29(1):15-31.Endocr Relat Cancer2021-11-24T00:00:002021Inhibition of GATA2 in prostate cancer by a clinically available small molecule.Authorship 129779Authorship 1032320734693385DiNardo AR, Nishiguchi T, Grimm SL, Schlesinger LS, Graviss EA, Cirillo JD, Coarfa C, Mandalakas AM, Heyckendorf J, Kaufmann SHE, Lange C, Netea MG, Van Crevel RMed (New York, N.Y.)Tuberculosis endotypes to guide stratified host-directed therapy. Med (N Y). 2021 03 12; 2(3):217-232.Med (N Y)2021-01-16T00:00:002021Tuberculosis endotypes to guide stratified host-directed therapy.Authorship 10335467Authorship 10336493Authorship 10342062734782721Gu G, Tian L, Herzog SK, Rechoum Y, Gelsomino L, Gao M, Du L, Kim JA, Dustin D, Lo HC, Beyer AR, Edwards DG, Gonzalez T, Tsimelzon A, Huang HJ, Fernandez NM, Grimm SL, Hilsenbeck SG, Liu D, Xu J, Alaniz A, Li S, Mills GB, Janku F, Kittler R, Zhang XH, Coarfa C, Foulds CE, Symmans WF, And? S, Fuqua SAWOncogeneCorrection to: Hormonal modulation of ESR1 mutant metastasis. Oncogene. 2022 Jan; 41(3):460.Oncogene2022-01-01T00:00:002022Correction to: Hormonal modulation of ESR1 mutant metastasis.34725362Matrone G, Jung SY, Choi JM, Jain A, Leung HE, Rajapakshe K, Coarfa C, Rodor J, Denvir MA, Baker AH, Cooke JPNature communicationsNuclear S-nitrosylation impacts tissue regeneration in zebrafish. Nat Commun. 2021 11 01; 12(1):6282.Nat Commun2021-11-01T00:00:002021Nuclear S-nitrosylation impacts tissue regeneration in zebrafish.34732579Bomidi C, Robertson M, Coarfa C, Estes MK, Blutt SEProceedings of the National Academy of Sciences of the United States of AmericaSingle-cell sequencing of rotavirus-infected intestinal epithelium reveals cell-type specific epithelial repair and tuft cell infection. Proc Natl Acad Sci U S A. 2021 11 09; 118(45).Proc Natl Acad Sci U S A2021-11-09T00:00:002021Single-cell sequencing of rotavirus-infected intestinal epithelium reveals cell-type specific epithelial repair and tuft cell infection.Authorship 10352151534890627Chitsazzadeh V, Nguyen TN, de Mingo Pulido A, Bittencourt BB, Du L, Adelmann CH, Ortiz Rivera I, Nguyen KA, Guerra LD, Davis A, Napoli M, Ma W, Davis RE, Rajapakshe K, Coarfa C, Flores ER, Tsai KYThe Journal of investigative dermatologymiR-181a Promotes Multiple Protumorigenic Functions by Targeting TGF?R3. J Invest Dermatol. 2022 07; 142(7):1956-1965.e2.J Invest Dermatol2021-12-08T00:00:002021miR-181a Promotes Multiple Protumorigenic Functions by Targeting TGF?R3.true1Adjunct Associate ProfessorAdjunct Associate ProfessorAuthorship 103762810Authorship 1037742835078977Sauler M, McDonough JE, Adams TS, Kothapalli N, Barnthaler T, Werder RB, Schupp JC, Nouws J, Robertson MJ, Coarfa C, Yang T, Chioccioli M, Omote N, Cosme C, Poli S, Ayaub EA, Chu SG, Jensen KH, Gomez JL, Britto CJ, Raredon MSB, Niklason LE, Wilson AA, Timshel PN, Kaminski N, Rosas IONature communicationsCharacterization of the COPD alveolar niche using single-cell RNA sequencing. Nat Commun. 2022 01 25; 13(1):494.Nat Commun2022-01-25T00:00:002022Characterization of the COPD alveolar niche using single-cell RNA sequencing.35174853Nakahata K, Simons BW, Pozzo E, Shuck R, Kurenbekova L, Prudowsky Z, Dholakia K, Coarfa C, Patel TD, Donehower LA, Yustein JTDisease models & mechanismsK-Ras and p53 mouse model with molecular characteristics of human rhabdomyosarcoma and translational applications. Dis Model Mech. 2022 02 01; 15(2).Dis Model Mech2022-02-01T00:00:002022K-Ras and p53 mouse model with molecular characteristics of human rhabdomyosarcoma and translational applications.Authorship 10382928Authorship 103889411Authorship 103889910Authorship 103923811Authorship 104058721Authorship 104093612Authorship 104157015Authorship 1041716835193933Sousa LG, Rajapakshe K, Rodriguez Canales J, Chin RL, Feng L, Wang Q, Barrese TZ, Massarelli E, William W, Johnson FM, Ferrarotto R, Wistuba I, Coarfa C, Lee J, Wang J, Melief CJM, Curran MA, Glisson BSJournal for immunotherapy of cancerISA101 and nivolumab for HPV-16+ cancer: updated clinical efficacy and immune correlates of response. 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Microorganisms. 2023 Aug 19; 11(8).Microorganisms2023-08-19T00:00:002023Multiomic Investigations into Lung Health and Disease.37693622Zhang L, Hsu JI, Braekeleer ED, Chen CW, Patel TD, Martell AG, Guzman AG, Wohlan K, Waldvogel SM, Urya H, Tovy A, Callen E, Murdaugh R, Richard R, Jansen S, Vissers L, de Vries BBA, Nussenzweig A, Huang S, Coarfa C, Anastas JN, Takahashi K, Vassiliou G, Goodell MAbioRxiv : the preprint server for biologySOD1 is a synthetic lethal target in PPM1D-mutant leukemia cells. bioRxiv. 2024 Jan 17.bioRxiv2024-01-17T00:00:002024SOD1 is a synthetic lethal target in PPM1D-mutant leukemia cells.37689587Bariani MV, Cui YH, Ali M, Bai T, Grimm SL, Coarfa C, Walker CL, He YY, Yang Q, Al-Hendy ACellular and molecular life sciences : CMLSTGF? signaling links early life endocrine-disrupting chemicals exposure to suppression of nucleotide excision repair in rat myometrial stem cells. Cell Mol Life Sci. 2023 Sep 09; 80(10):288.Cell Mol Life Sci2023-09-09T00:00:002023TGF? signaling links early life endocrine-disrupting chemicals exposure to suppression of nucleotide excision repair in rat myometrial stem cells.37530747Pettit RW, Byun J, Han Y, Ostrom QT, Coarfa C, Bondy ML, Amos CICancer epidemiology, biomarkers & prevention : a publication of the American Association for Cancer Research, cosponsored by the American Society of Preventive OncologyHeritable Traits and Lung Cancer Risk: A Two-Sample Mendelian Randomization Study. 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J Clin Invest. 2023 11 01; 133(21).J Clin Invest2023-11-01T00:00:002023Human intestinal organoids from Cronkhite-Canada syndrome patients reveal link between serotonin and proliferation.37906431Ahn S, Park JH, Grimm SL, Piyarathna DWB, Samanta T, Putluri V, Mezquita D, Fuqua SAW, Putluri N, Coarfa C, Kaipparettu BACancer researchMetabolomic Rewiring Promotes Endocrine Therapy Resistance in Breast Cancer. Cancer Res. 2024 01 16; 84(2):291-304.Cancer Res2024-01-16T00:00:002024Metabolomic Rewiring Promotes Endocrine Therapy Resistance in Breast Cancer.Authorship 10837862338038968Awad D, Cao PHA, Pulliam TL, Spradlin M, Subramani E, Tellman TV, Ribeiro CF, Muzzioli R, Jewell BE, Pakula H, Ackroyd JJ, Murray MM, Han JJ, Leng M, Jain A, Piyarathna B, Liu J, Song X, Zhang J, Klekers AR, Drake JM, Ittmann MM, Coarfa C, Piwnica-Worms D, Farach-Carson MC, Loda M, Eberlin LS, Frigo DECancer researchAdipose Triglyceride Lipase Is a Therapeutic Target in Advanced Prostate Cancer That Promotes Metabolic Plasticity. Cancer Res. 2024 03 04; 84(5):703-724.Cancer Res2024-03-04T00:00:002024Adipose Triglyceride Lipase Is a Therapeutic Target in Advanced Prostate Cancer That Promotes Metabolic Plasticity.Authorship 10854581038101412Joshi CS, Salazar AM, Wang C, Ligon MM, Chappidi RR, Fashemi BE, Felder PA, Mora A, Grimm SL, Coarfa C, Mysorekar IUDevelopmental cellD-Mannose reduces cellular senescence and NLRP3/GasderminD/IL-1?-driven pyroptotic uroepithelial cell shedding in the murine bladder. Dev Cell. 2024 Jan 08; 59(1):33-47.e5.Dev Cell2023-12-14T00:00:002023D-Mannose reduces cellular senescence and NLRP3/GasderminD/IL-1?-driven pyroptotic uroepithelial cell shedding in the murine bladder.Authorship 1086318638165157Napoli M, Deshpande AA, Chakravarti D, Rajapakshe K, Gunaratne PH, Coarfa C, Flores ERCancer research communicationsGenome-wide p63-Target Gene Analyses Reveal TAp63/NRF2-Dependent Oxidative Stress Responses. 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Diabetes. 2024 Apr 01; 73(4):628-636.Diabetes2024-04-01T00:00:002024Distinct Amino Acid Profile Characterizes Youth With or at Risk for Type 2 Diabetes.Authorship 1089488438370754Emig AA, Hansen M, Grimm S, Coarfa C, Lord ND, Williams MKbioRxiv : the preprint server for biologyTemporal dynamics of BMP/Nodal ratio drive tissue-specific gastrulation morphogenesis. bioRxiv. 2024 Feb 07.bioRxiv2024-02-07T00:00:002024Temporal dynamics of BMP/Nodal ratio drive tissue-specific gastrulation morphogenesis.Authorship 10904471038464252Chowdhury P, Wang X, Love JF, Vargas-Hernandez S, Nakatani Y, Grimm SL, Mezquita D, Mason FM, Martinez ED, Coarfa C, Walker CL, Gustavsson AK, Dere RbioRxiv : the preprint server for biologyLysine Demethylase 4A is a Centrosome Associated Protein Required for Centrosome Integrity and Genomic Stability. bioRxiv. 2024 Feb 21.bioRxiv2024-02-21T00:00:002024Lysine Demethylase 4A is a Centrosome Associated Protein Required for Centrosome Integrity and Genomic Stability.true1ProfessorProfessortrue1ProfessorProfessortrue1ProfessorProfessortrue1ProfessorProfessortrue1ProfessorProfessortrue1ProfessorProfessorAuthorship 192923Authorship 322674Authorship 1415872Authorship 1419204Authorship 1419455Authorship 142284224391148Kunde-Ramamoorthy G, Coarfa C, Laritsky E, Kessler NJ, Harris RA, Xu M, Chen R, Shen L, Milosavljevic A, Waterland RANucleic acids researchComparison and quantitative verification of mapping algorithms for whole-genome bisulfite sequencing. 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Proc Natl Acad Sci U S A. 2014 Feb 04; 111(5):E572-81.Proc Natl Acad Sci U S A2014-01-21T00:00:002014Induced multipotency in adult keratinocytes through down-regulation of ?Np63 or DGCR8.24675677Kannan K, Coarfa C, Rajapakshe K, Hawkins SM, Matzuk MM, Milosavljevic A, Yen LPLoS geneticsCDKN2D-WDFY2 is a cancer-specific fusion gene recurrent in high-grade serous ovarian carcinoma. PLoS Genet. 2014 Mar; 10(3):e1004216.PLoS Genet2014-03-27T00:00:002014CDKN2D-WDFY2 is a cancer-specific fusion gene recurrent in high-grade serous ovarian carcinoma.Authorship 492082Authorship 509792Authorship 41553Authorship 1460082Authorship 147054524694284Ma J, Coarfa C, Qin X, Bonnen PE, Milosavljevic A, Versalovic J, Aagaard KBMC genomicsmtDNA haplogroup and single nucleotide polymorphisms structure human microbiome communities. BMC Genomics. 2014 Apr 03; 15:257.BMC Genomics2014-04-03T00:00:002014mtDNA haplogroup and single nucleotide polymorphisms structure human microbiome communities.24874954Feng Q, Zhang Z, Shea MJ, Creighton CJ, Coarfa C, Hilsenbeck SG, Lanz R, He B, Wang L, Fu X, Nardone A, Song Y, Bradner J, Mitsiades N, Mitsiades CS, Osborne CK, Schiff R, O'Malley BWCell researchAn epigenomic approach to therapy for tamoxifen-resistant breast cancer. 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Proc Natl Acad Sci U S A. 2014 Aug 05; 111(31):11467-72.Proc Natl Acad Sci U S A2014-07-21T00:00:002014PAPD5-mediated 3' adenylation and subsequent degradation of miR-21 is disrupted in proliferative disease.25080362Coarfa C, Pichot C, Jackson A, Tandon A, Amin V, Raghuraman S, Paithankar S, Lee AV, McGuire SE, Milosavljevic ABMC bioinformaticsAnalysis of interactions between the epigenome and structural mutability of the genome using Genboree Workbench tools. BMC Bioinformatics. 2014; 15 Suppl 7:S2.BMC Bioinformatics2014-05-28T00:00:002014Analysis of interactions between the epigenome and structural mutability of the genome using Genboree Workbench tools.Authorship 517831Authorship 5403411Authorship 760309Authorship 568885Authorship 1518361325274033Geng C, Rajapakshe K, Shah SS, Shou J, Eedunuri VK, Foley C, Fiskus W, Rajendran M, Chew SA, Zimmermann M, Bond R, He B, Coarfa C, Mitsiades NCancer researchAndrogen receptor is the key transcriptional mediator of the tumor suppressor SPOP in prostate cancer. Cancer Res. 2014 Oct 01; 74(19):5631-43.Cancer Res2014-10-01T00:00:002014Androgen receptor is the key transcriptional mediator of the tumor suppressor SPOP in prostate cancer.Authorship 636342Authorship 940413Authorship 751036Authorship 1546942Authorship 15542325