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PTEN status is a crucial determinant of the functional outcome of combined MEK and mTOR inhibition in cancer.
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PTEN status is a crucial determinant of the functional outcome of combined MEK and mTOR inhibition in cancer.
PTEN status is a crucial determinant of the functional outcome of combined MEK and mTOR inhibition in cancer. Sci Rep. 2017 02 21; 7:43013.
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PubMed
subject areas
Animals
Cell Line, Tumor
Drug Synergism
Everolimus
Female
Humans
Janus Kinase 1
MAP Kinase Kinase Kinases
Mice
Mice, Nude
Neoplastic Stem Cells
Phosphatidylinositol 3-Kinases
Protein Kinase Inhibitors
Proto-Oncogene Proteins c-akt
PTEN Phosphohydrolase
Pyridones
Pyrimidinones
RNA Interference
RNA, Small Interfering
STAT3 Transcription Factor
TOR Serine-Threonine Kinases
authors with profiles
MICHAEL ANDREEFF
MARINA KONOPLEVA