MARTAALONSOMARTA ALONSO14337ALONSO, MARTAVisiting Assistant Professorprns:coAuthorOfcoauthor ofFaculty Rankprns:fullNamefull nameprns:hasAuthorListauthor listprns:hasFacultyRankhas faculty rankprns:hasNetworkhas networkprns:hasPublicationVenuepublished inprns:informationResourceReferenceinformation resource referenceprns:isPrimaryPositionis primary positionprns:latitudelatitudeprns:longitudelongitudeprns:maxWeightmaximum weightprns:medlineTAjournal title abbreviationprns:meshDescriptorUIMeSH DescriptorUIprns:meshSemanticGroupNameMeSH semantic group nameprns:minWeightminimum weightprns:numberOfAuthorsnumber of authorsprns:numberOfConnectionsnumber of connectionsprns:numberOfPublicationsnumber of publicationsprns:personIdPerson IDprns:personInPrimaryPositionperson in primary positionprns:positionInDepartmentposition in departmentprns:positionInDivisionposition in divisionprns:predicateNodepredicate nodeprns:publicationDatepublication dateprns:similarTosimilar toprns:sortOrdersort orderprns:uniquenessWeightuniqueness weightprns:yearyearAcademic ArticleArticleDocumentbibo:pmidPubMed IdentifierAddressvivo:address1address line 1vivo:addressCitycityvivo:addressPostalCodepostal codevivo:addressStatestate or provincevivo:authorInAuthorshipselected publicationsvivo:authorRankauthor rank in publicationAuthorshipDepartmentDivisionvivo:hasResearchArearesearch areasvivo:hrJobTitleHR job titleInformation Resourcevivo:linkedAuthorlinked authorvivo:linkedInformationResourcelinked information resourcevivo:mailingAddressmailing addressvivo:personInPositionpositionsPositionvivo:positionInOrganizationposition in organizationvivo:preferredTitlepreferred titlerdf:predicatepredicaterdf:typetyperdfs:labellabelConceptAgentfoaf:firstNamefirst namefoaf:lastNamelast nameOrganizationPerson16207474Jiang H, Alemany R, Gomez-Manzano C, Medrano DR, Lemoine MG, Olson MV, Alonso MM, Lee OH, Conrad CC, Yung WK, Fueyo JNeoplasia (New York, N.Y.)Downmodulation of E1A protein expression as a novel strategy to design cancer-selective adenoviruses. Neoplasia. 2005 Aug; 7(8):723-9.Neoplasia2005-08-01T00:00:002005Downmodulation of E1A protein expression as a novel strategy to design cancer-selective adenoviruses.18006852Liu JL, Mao Z, LaFortune TA, Alonso MM, Gallick GE, Fueyo J, Yung WKCancer researchCell cycle-dependent nuclear export of phosphatase and tensin homologue tumor suppressor is regulated by the phosphoinositide-3-kinase signaling cascade. Cancer Res. 2007 Nov 15; 67(22):11054-63.Cancer Res2007-11-15T00:00:002007Cell cycle-dependent nuclear export of phosphatase and tensin homologue tumor suppressor is regulated by the phosphoinositide-3-kinase signaling cascade.18089777Alonso MM, Gomez-Manzano C, Bekele BN, Yung WK, Fueyo JCancer researchAdenovirus-based strategies overcome temozolomide resistance by silencing the O6-methylguanine-DNA methyltransferase promoter. Cancer Res. 2007 Dec 15; 67(24):11499-504.Cancer Res2007-12-15T00:00:002007Adenovirus-based strategies overcome temozolomide resistance by silencing the O6-methylguanine-DNA methyltransferase promoter.Neuro-OncologyMD AndersonFREDERICK FLANG JRFREDERICK F LANG JR8665LANG JR, FREDERICK FProfessorCANDELARIAGOMEZ-MANZANOCANDELARIA GOMEZ-MANZANO8676GOMEZ-MANZANO, CANDELARIAAssociate ProfessorHONGJIANGHONG JIANG8737JIANG, HONGAssociate ProfessorAMY BHEIMBERGERAMY B HEIMBERGER9035HEIMBERGER, AMY BProfessorJUANFUEYO-MARGARETOJUAN FUEYO-MARGARETO8674FUEYO-MARGARETO, JUANProfessor16628012Alonso MM, Fueyo J, Yung WK, Gomez-Manzano CCell cycle (Georgetown, Tex.)E2F1 and telomerase: alliance in the dark side. Cell Cycle. 2006 May; 5(9):930-5.Cell Cycle2006-05-01T00:00:002006E2F1 and telomerase: alliance in the dark side.17134363Jiang H, Alonso MM, Gomez-Manzano C, Piao Y, Fueyo JExpert review of anticancer therapyOncolytic viruses and DNA-repair machinery: overcoming chemoresistance of gliomas. Expert Rev Anticancer Ther. 2006 Nov; 6(11):1585-92.Expert Rev Anticancer Ther2006-11-01T00:00:002006Oncolytic viruses and DNA-repair machinery: overcoming chemoresistance of gliomas.16264179Alonso MM, Fueyo J, Shay JW, Aldape KD, Jiang H, Lee OH, Johnson DG, Xu J, Kondo Y, Kanzawa T, Kyo S, Bekele BN, Zhou X, Nigro J, McDonald JM, Yung WK, Gomez-Manzano CJournal of the National Cancer InstituteExpression of transcription factor E2F1 and telomerase in glioblastomas: mechanistic linkage and prognostic significance. J Natl Cancer Inst. 2005 Nov 02; 97(21):1589-600.J Natl Cancer Inst2005-11-02T00:00:002005Expression of transcription factor E2F1 and telomerase in glioblastomas: mechanistic linkage and prognostic significance.17065226Jiang H, Olson MV, Medrano DR, Lee OH, Xu J, Piao Y, Alonso MM, Gomez-Manzano C, Hung MC, Yung WK, Fueyo JFASEB journal : official publication of the Federation of American Societies for Experimental BiologyA novel CRM1-dependent nuclear export signal in adenoviral E1A protein regulated by phosphorylation. FASEB J. 2006 Dec; 20(14):2603-5.FASEB J2006-10-25T00:00:002006A novel CRM1-dependent nuclear export signal in adenoviral E1A protein regulated by phosphorylation.17483310Olson MV, Johnson DG, Jiang H, Xu J, Alonso MM, Aldape KD, Fuller GN, Bekele BN, Yung WK, Gomez-Manzano C, Fueyo JCancer researchTransgenic E2F1 expression in the mouse brain induces a human-like bimodal pattern of tumors. Cancer Res. 2007 May 01; 67(9):4005-9.Cancer Res2007-05-01T00:00:002007Transgenic E2F1 expression in the mouse brain induces a human-like bimodal pattern of tumors.18756625Gomez-Manzano C, Alonso M, Jiang H, Fueyo JCancer biology & therapyInterspecies adenovirus fiber shows "evolutionary" advantage for oncolytic therapy of gliomas. Cancer Biol Ther. 2008 May; 7(5):794-6.Cancer Biol Ther2008-05-01T00:00:002008Interspecies adenovirus fiber shows "evolutionary" advantage for oncolytic therapy of gliomas.20935482Jiang H, Martin V, Alonso M, Gomez-Manzano C, Fueyo JAutophagyRB-E2F1: molecular rheostat for autophagy and apoptosis. Autophagy. 2010 Nov; 6(8):1216-7.Autophagy2010-11-16T00:00:002010RB-E2F1: molecular rheostat for autophagy and apoptosis.21948473Alonso MM, Jiang H, Gomez-Manzano C, Fueyo JMethods in molecular biology (Clifton, N.J.)Targeting brain tumor stem cells with oncolytic adenoviruses. Methods Mol Biol. 2012; 797:111-25.Methods Mol Biol2012-01-01T00:00:002012Targeting brain tumor stem cells with oncolytic adenoviruses.24809734Gabrusiewicz K, Liu D, Cortes-Santiago N, Hossain MB, Conrad CA, Aldape KD, Fuller GN, Marini FC, Alonso MM, Idoate MA, Gilbert MR, Fueyo J, Gomez-Manzano COncotargetAnti-vascular endothelial growth factor therapy-induced glioma invasion is associated with accumulation of Tie2-expressing monocytes. Oncotarget. 2014 Apr 30; 5(8):2208-20.Oncotarget2014-04-30T00:00:002014Anti-vascular endothelial growth factor therapy-induced glioma invasion is associated with accumulation of Tie2-expressing monocytes.17579575Cascallo M, Alonso MM, Rojas JJ, Perez-Gimenez A, Fueyo J, Alemany RMolecular therapy : the journal of the American Society of Gene TherapySystemic toxicity-efficacy profile of ICOVIR-5, a potent and selective oncolytic adenovirus based on the pRB pathway. Mol Ther. 2007 Sep; 15(9):1607-15.Mol Ther2007-06-19T00:00:002007Systemic toxicity-efficacy profile of ICOVIR-5, a potent and selective oncolytic adenovirus based on the pRB pathway.18334281Alonso MM, Alemany R, Fueyo J, Gomez-Manzano CCancer lettersE2F1 in gliomas: a paradigm of oncogene addiction. Cancer Lett. 2008 May 18; 263(2):157-63.Cancer Lett2008-03-10T00:00:002008E2F1 in gliomas: a paradigm of oncogene addiction.21321379Liu D, Martin V, Fueyo J, Lee OH, Xu J, Cortes-Santiago N, Alonso MM, Aldape K, Colman H, Gomez-Manzano COncotargetTie2/TEK modulates the interaction of glioma and brain tumor stem cells with endothelial cells and promotes an invasive phenotype. Oncotarget. 2010 Dec; 1(8):700-9.Oncotarget2010-12-01T00:00:002010Tie2/TEK modulates the interaction of glioma and brain tumor stem cells with endothelial cells and promotes an invasive phenotype.24737304Martinez-Velez N, Xipell E, Jauregui P, Zalacain M, Marrodan L, Zandueta C, Vera B, Urquiza L, Sierrases?maga L, Juli?n MS, Toledo G, Fueyo J, Gomez-Manzano C, Torre W, Lecanda F, Pati?o-Garc?a A, Alonso MMJournal of bone and mineral research : the official journal of the American Society for Bone and Mineral ResearchThe oncolytic adenovirus ?24-RGD in combination with cisplatin exerts a potent anti-osteosarcoma activity. J Bone Miner Res. 2014 Oct; 29(10):2287-96.J Bone Miner Res2014-10-01T00:00:002014The oncolytic adenovirus ?24-RGD in combination with cisplatin exerts a potent anti-osteosarcoma activity.74Professor98Visiting Assistant Professor14Associate Professor6Adjunct Professor26910374Cortes-Santiago N, Hossain MB, Gabrusiewicz K, Fan X, Gumin J, Marini FC, Alonso MM, Lang F, Yung WK, Fueyo J, Gomez-Manzano COncotargetSoluble Tie2 overrides the heightened invasion induced by anti-angiogenesis therapies in gliomas. Oncotarget. 2016 Mar 29; 7(13):16146-57.Oncotarget2016-03-29T00:00:002016Soluble Tie2 overrides the heightened invasion induced by anti-angiogenesis therapies in gliomas.26951384Xipell E, Arag?n T, Mart?nez-Velez N, Vera B, Idoate MA, Mart?nez-Irujo JJ, Garz?n AG, Gonzalez-Huarriz M, Acanda AM, Jones C, Lang FF, Fueyo J, Gomez-Manzano C, Alonso MMNeuro-oncologyEndoplasmic reticulum stress-inducing drugs sensitize glioma cells to temozolomide through downregulation of MGMT, MPG, and Rad51. Neuro Oncol. 2016 08; 18(8):1109-19.Neuro Oncol2016-03-06T00:00:002016Endoplasmic reticulum stress-inducing drugs sensitize glioma cells to temozolomide through downregulation of MGMT, MPG, and Rad51.27121320Xipell E, Gonzalez-Huarriz M, Martinez de Irujo JJ, Garc?a-Garz?n A, Lang FF, Jiang H, Fueyo J, Gomez-Manzano C, Alonso MMOncotargetSalinomycin induced ROS results in abortive autophagy and leads to regulated necrosis in glioblastoma. Oncotarget. 2016 May 24; 7(21):30626-41.Oncotarget2016-05-24T00:00:002016Salinomycin induced ROS results in abortive autophagy and leads to regulated necrosis in glioblastoma.17189382Lee OH, Xu J, Fueyo J, Fuller GN, Aldape KD, Alonso MM, Piao Y, Liu TJ, Lang FF, Bekele BN, Gomez-Manzano CMolecular cancer research : MCRExpression of the receptor tyrosine kinase Tie2 in neoplastic glial cells is associated with integrin beta1-dependent adhesion to the extracellular matrix. Mol Cancer Res. 2006 Dec; 4(12):915-26.Mol Cancer Res2006-12-01T00:00:002006Expression of the receptor tyrosine kinase Tie2 in neoplastic glial cells is associated with integrin beta1-dependent adhesion to the extracellular matrix.15014451Gomez-Manzano C, Balague C, Alemany R, Lemoine MG, Mitlianga P, Jiang H, Khan A, Alonso M, Lang FF, Conrad CA, Liu TJ, Bekele BN, Yung WK, Fueyo JOncogeneA novel E1A-E1B mutant adenovirus induces glioma regression in vivo. Oncogene. 2004 Mar 11; 23(10):1821-8.Oncogene2004-03-11T00:00:002004A novel E1A-E1B mutant adenovirus induces glioma regression in vivo.17848677Jiang H, Gomez-Manzano C, Aoki H, Alonso MM, Kondo S, McCormick F, Xu J, Kondo Y, Bekele BN, Colman H, Lang FF, Fueyo JJournal of the National Cancer InstituteExamination of the therapeutic potential of Delta-24-RGD in brain tumor stem cells: role of autophagic cell death. J Natl Cancer Inst. 2007 Sep 19; 99(18):1410-4.J Natl Cancer Inst2007-09-11T00:00:002007Examination of the therapeutic potential of Delta-24-RGD in brain tumor stem cells: role of autophagic cell death.22069467Alonso MM, Diez-Valle R, Manterola L, Rubio A, Liu D, Cortes-Santiago N, Urquiza L, Jauregi P, Lopez de Munain A, Sampron N, Aramburu A, Tejada-Sol?s S, Vicente C, Odero MD, Bandr?s E, Garc?a-Foncillas J, Idoate MA, Lang FF, Fueyo J, Gomez-Manzano CPloS oneGenetic and epigenetic modifications of Sox2 contribute to the invasive phenotype of malignant gliomas. PLoS One. 2011; 6(11):e26740.PLoS One2011-11-01T00:00:002011Genetic and epigenetic modifications of Sox2 contribute to the invasive phenotype of malignant gliomas.17804740Alonso MM, Cascallo M, Gomez-Manzano C, Jiang H, Bekele BN, Perez-Gimenez A, Lang FF, Piao Y, Alemany R, Fueyo JCancer researchICOVIR-5 shows E2F1 addiction and potent antiglioma effect in vivo. Cancer Res. 2007 Sep 01; 67(17):8255-63.Cancer Res2007-09-01T00:00:002007ICOVIR-5 shows E2F1 addiction and potent antiglioma effect in vivo.18253154Alonso MM, Jiang H, Yokoyama T, Xu J, Bekele NB, Lang FF, Kondo S, Gomez-Manzano C, Fueyo JMolecular therapy : the journal of the American Society of Gene TherapyDelta-24-RGD in combination with RAD001 induces enhanced anti-glioma effect via autophagic cell death. Mol Ther. 2008 Mar; 16(3):487-93.Mol Ther2008-02-05T00:00:002008Delta-24-RGD in combination with RAD001 induces enhanced anti-glioma effect via autophagic cell death.16428500Gomez-Manzano C, Alonso MM, Yung WK, McCormick F, Curiel DT, Lang FF, Jiang H, Bekele BN, Zhou X, Alemany R, Fueyo JClinical cancer research : an official journal of the American Association for Cancer ResearchDelta-24 increases the expression and activity of topoisomerase I and enhances the antiglioma effect of irinotecan. Clin Cancer Res. 2006 Jan 15; 12(2):556-62.Clin Cancer Res2006-01-15T00:00:002006Delta-24 increases the expression and activity of topoisomerase I and enhances the antiglioma effect of irinotecan.29432077Lang FF, Conrad C, Gomez-Manzano C, Yung WKA, Sawaya R, Weinberg JS, Prabhu SS, Rao G, Fuller GN, Aldape KD, Gumin J, Vence LM, Wistuba I, Rodriguez-Canales J, Villalobos PA, Dirven CMF, Tejada S, Valle RD, Alonso MM, Ewald B, Peterkin JJ, Tufaro F, Fueyo JJournal of clinical oncology : official journal of the American Society of Clinical OncologyPhase I Study of DNX-2401 (Delta-24-RGD) Oncolytic Adenovirus: Replication and Immunotherapeutic Effects in Recurrent Malignant Glioma. J Clin Oncol. 2018 05 10; 36(14):1419-1427.J Clin Oncol2018-02-12T00:00:002018Phase I Study of DNX-2401 (Delta-24-RGD) Oncolytic Adenovirus: Replication and Immunotherapeutic Effects in Recurrent Malignant Glioma.D050130Procedures952780.775668Oncolytic Virotherapy6701 Fannin StHouston, 77030TX6.648290.00498172312research areas4.234950.018679922coauthor of125.26812.262459similar to1186selected publicationsD050504Living Beings761940.822435Oncolytic VirusesD000256Living Beings38514570.650438AdenoviridaeD005910Disorders38619630.43438GliomaAuthorship 8971478Authorship 8972517Authorship 8977042Authorship 8978692Authorship 8982221Authorship 8982324Authorship 8982372Authorship 8983181Authorship 8985045Authorship 8985191Authorship 8985227Authorship 8985471Authorship 8986931Authorship 8988181Authorship 8988264Authorship 8988701Authorship 8989572Authorship 8989622Authorship 8994736Authorship 9000253Authorship 9003307Authorship 9004829Authorship 9008401Authorship 9012031Authorship 90200612Authorship 9022104Authorship 9033958Authorship 9034169Authorship 90342015Authorship 9042376Authorship 9046509Authorship 9046978Authorship 9060276Authorship 9063807Authorship 9083255Authorship 9106887Authorship 91087710Authorship 91501519Authorship 9158152Authorship 91714473Authorship 9171657Authorship 9206334Authorship 9216767Authorship 9225318Authorship 9285536Authorship 9286422Authorship 92888916Authorship 9302413Authorship 93027515Authorship 93522555Authorship 9365068Authorship 939642217583490Villar J, Celay J, Alonso MM, Rotinen M, de Miguel C, Migliaccio M, Enc?o IThe Journal of steroid biochemistry and molecular biologyTranscriptional regulation of the human type 8 17beta-hydroxysteroid dehydrogenase gene by C/EBPbeta. J Steroid Biochem Mol Biol. 2007 Jun-Jul; 105(1-5):131-9.J Steroid Biochem Mol Biol2007-05-16T00:00:002007Transcriptional regulation of the human type 8 17beta-hydroxysteroid dehydrogenase gene by C/EBPbeta.18852215Rotinen M, Celay J, Alonso MM, Arrazola A, Encio I, Villar JThe Journal of endocrinologyEstradiol induces type 8 17beta-hydroxysteroid dehydrogenase expression: crosstalk between estrogen receptor alpha and C/EBPbeta. J Endocrinol. 2009 Jan; 200(1):85-92.J Endocrinol2008-10-13T00:00:002008Estradiol induces type 8 17beta-hydroxysteroid dehydrogenase expression: crosstalk between estrogen receptor alpha and C/EBPbeta.21948564Bitarte N, Bandres E, Boni V, Zarate R, Rodriguez J, Gonzalez-Huarriz M, Lopez I, Javier Sola J, Alonso MM, Fortes P, Garcia-Foncillas JStem cells (Dayton, Ohio)MicroRNA-451 is involved in the self-renewal, tumorigenicity, and chemoresistance of colorectal cancer stem cells. Stem Cells. 2011 Nov; 29(11):1661-71.Stem Cells2011-11-01T00:00:002011MicroRNA-451 is involved in the self-renewal, tumorigenicity, and chemoresistance of colorectal cancer stem cells.24155920Aldaz B, Sagardoy A, Nogueira L, Guruceaga E, Grande L, Huse JT, Aznar MA, D?ez-Valle R, Tejada-Sol?s S, Alonso MM, Fernandez-Luna JL, Martinez-Climent JA, Malumbres RPloS oneInvolvement of miRNAs in the differentiation of human glioblastoma multiforme stem-like cells. PLoS One. 2013; 8(10):e77098.PLoS One2013-10-14T00:00:002013Involvement of miRNAs in the differentiation of human glioblastoma multiforme stem-like cells.24435880Manterola L, Guruceaga E, G?llego P?rez-Larraya J, Gonz?lez-Huarriz M, Jauregui P, Tejada S, Diez-Valle R, Segura V, Sampr?n N, Barrena C, Ruiz I, Agirre A, Ayuso A, Rodr?guez J, Gonz?lez A, Xipell E, Matheu A, L?pez de Munain A, Tu??n T, Zazpe I, Garc?a-Foncillas J, Paris S, Delattre JY, Alonso MMNeuro-oncologyA small noncoding RNA signature found in exosomes of GBM patient serum as a diagnostic tool. Neuro Oncol. 2014 Apr; 16(4):520-7.Neuro Oncol2014-01-16T00:00:002014A small noncoding RNA signature found in exosomes of GBM patient serum as a diagnostic tool.25328137O'Loghlen A, Martin N, Krusche B, Pemberton H, Alonso MM, Chandler H, Brookes S, Parrinello S, Peters G, Gil JOncogeneThe nuclear receptor NR2E1/TLX controls senescence. Oncogene. 2015 Jul 30; 34(31):4069-4077.Oncogene2014-10-20T00:00:002014The nuclear receptor NR2E1/TLX controls senescence.25057435de la Rocha AM, Sampron N, Alonso MM, Matheu AAmerican journal of cancer researchRole of SOX family of transcription factors in central nervous system tumors. Am J Cancer Res. 2014; 4(4):312-24.Am J Cancer Res2014-07-16T00:00:002014Role of SOX family of transcription factors in central nervous system tumors.26603261Mart?nez-V?lez N, Xipell E, Vera B, Acanda de la Rocha A, Zalacain M, Marrod?n L, Gonzalez-Huarriz M, Toledo G, Cascallo M, Alemany R, Pati?o A, Alonso MMClinical cancer research : an official journal of the American Association for Cancer ResearchThe Oncolytic Adenovirus VCN-01 as Therapeutic Approach Against Pediatric Osteosarcoma. Clin Cancer Res. 2016 05 01; 22(9):2217-25.Clin Cancer Res2015-11-24T00:00:002015The Oncolytic Adenovirus VCN-01 as Therapeutic Approach Against Pediatric Osteosarcoma.26808201Vera B, Mart?nez-V?lez N, Xipell E, Acanda de la Rocha A, Pati?o-Garc?a A, Saez-Castresana J, Gonzalez-Huarriz M, Cascallo M, Alemany R, Alonso MMPloS oneCharacterization of the Antiglioma Effect of the Oncolytic Adenovirus VCN-01. PLoS One. 2016; 11(1):e0147211.PLoS One2016-01-25T00:00:002016Characterization of the Antiglioma Effect of the Oncolytic Adenovirus VCN-01.27093696Klein SR, Jiang H, Hossain MB, Fan X, Gumin J, Dong A, Alonso MM, Gomez-Manzano C, Fueyo JPloS oneCritical Role of Autophagy in the Processing of Adenovirus Capsid-Incorporated Cancer-Specific Antigens. PLoS One. 2016; 11(4):e0153814.PLoS One2016-04-19T00:00:002016Critical Role of Autophagy in the Processing of Adenovirus Capsid-Incorporated Cancer-Specific Antigens.27269943Ramaswamy V, Hielscher T, Mack SC, Lassaletta A, Lin T, Pajtler KW, Jones DT, Luu B, Cavalli FM, Aldape K, Remke M, Mynarek M, Rutkowski S, Gururangan S, McLendon RE, Lipp ES, Dunham C, Hukin J, Eisenstat DD, Fulton D, van Landeghem FK, Santi M, van Veelen ML, Van Meir EG, Osuka S, Fan X, Muraszko KM, Tirapelli DP, Oba-Shinjo SM, Marie SK, Carlotti CG, Lee JY, Rao AA, Giannini C, Faria CC, Nunes S, Mora J, Hamilton RL, Hauser P, Jabado N, Petrecca K, Jung S, Massimi L, Zollo M, Cinalli G, Bogn?r L, Klekner A, Hortob?gyi T, Leary S, Ermoian RP, Olson JM, Leonard JR, Gardner C, Grajkowska WA, Chambless LB, Cain J, Eberhart CG, Ahsan S, Massimino M, Giangaspero F, Buttarelli FR, Packer RJ, Emery L, Yong WH, Soto H, Liau LM, Everson R, Grossbach A, Shalaby T, Grotzer M, Karajannis MA, Zagzag D, Wheeler H, von Hoff K, Alonso MM, Tu?on T, Sch?ller U, Zitterbart K, Sterba J, Chan JA, Guzman M, Elbabaa SK, Colman H, Dhall G, Fisher PG, Fouladi M, Gajjar A, Goldman S, Hwang E, Kool M, Ladha H, Vera-Bolanos E, Wani K, Lieberman F, Mikkelsen T, Omuro AM, Pollack IF, Prados M, Robins HI, Soffietti R, Wu J, Metellus P, Tabori U, Bartels U, Bouffet E, Hawkins CE, Rutka JT, Dirks P, Pfister SM, Merchant TE, Gilbert MR, Armstrong TS, Korshunov A, Ellison DW, Taylor MDJournal of clinical oncology : official journal of the American Society of Clinical OncologyTherapeutic Impact of Cytoreductive Surgery and Irradiation of Posterior Fossa Ependymoma in the Molecular Era: A Retrospective Multicohort Analysis. J Clin Oncol. 2016 07 20; 34(21):2468-77.J Clin Oncol2016-06-06T00:00:002016Therapeutic Impact of Cytoreductive Surgery and Irradiation of Posterior Fossa Ependymoma in the Molecular Era: A Retrospective Multicohort Analysis.27280773Vera B, Mart?nez-V?lez N, Xipell E, Acanda de la Rocha A, Pati?o-Garc?a A, Castresana JS, Gonzalez-Huarriz M, Cascallo M, Alemany R, Alonso MMPloS oneCorrection: Characterization of the Antiglioma Effect of the Oncolytic Adenovirus VCN-01. PLoS One. 2016; 11(6):e0157619.PLoS One2016-06-09T00:00:002016Correction: Characterization of the Antiglioma Effect of the Oncolytic Adenovirus VCN-01.27669421Acanda de la Rocha AM, L?pez-Bertoni H, Guruceaga E, Gonz?lez-Huarriz M, Mart?nez-V?lez N, Xipell E, Fueyo J, Gomez-Manzano C, Alonso MMPloS oneAnalysis of SOX2-Regulated Transcriptome in Glioma Stem Cells. PLoS One. 2016; 11(9):e0163155.PLoS One2016-09-26T00:00:002016Analysis of SOX2-Regulated Transcriptome in Glioma Stem Cells.28107439Marigil M, Martinez-Velez N, Dom?nguez PD, Idoate MA, Xipell E, Pati?o-Garc?a A, Gonzalez-Huarriz M, Garc?a-Moure M, Junier MP, Chneiweiss H, El-Habr E, Diez-Valle R, Tejada-Sol?s S, Alonso MMPloS oneDevelopment of a DIPG Orthotopic Model in Mice Using an Implantable Guide-Screw System. PLoS One. 2017; 12(1):e0170501.PLoS One2017-01-20T00:00:002017Development of a DIPG Orthotopic Model in Mice Using an Implantable Guide-Screw System.27902458Garc?a-Romero N, Carri?n-Navarro J, Esteban-Rubio S, L?zaro-Ib??ez E, Peris-Celda M, Alonso MM, Guzm?n-De-Villoria J, Fern?ndez-Carballal C, de Mendivil AO, Garc?a-Duque S, Escobedo-Lucea C, Prat-Ac?n R, Belda-Iniesta C, Ayuso-Sacido AOncotargetDNA sequences within glioma-derived extracellular vesicles can cross the intact blood-brain barrier and be detected in peripheral blood of patients. Oncotarget. 2017 Jan 03; 8(1):1416-1428.Oncotarget2017-01-03T00:00:002017DNA sequences within glioma-derived extracellular vesicles can cross the intact blood-brain barrier and be detected in peripheral blood of patients.29166609Moreno M, Pedrosa L, Par? L, Pineda E, Bejarano L, Mart?nez J, Balasubramaniyan V, Ezhilarasan R, Kallarackal N, Kim SH, Wang J, Audia A, Conroy S, Marin M, Ribalta T, Pujol T, Herreros A, Tortosa A, Mira H, Alonso MM, G?mez-Manzano C, Graus F, Sulman EP, Piao X, Nakano I, Prat A, Bhat KP, de la Iglesia NCell reportsGPR56/ADGRG1 Inhibits Mesenchymal Differentiation and Radioresistance in Glioblastoma. Cell Rep. 2017 Nov 21; 21(8):2183-2197.Cell Rep2017-11-21T00:00:002017GPR56/ADGRG1 Inhibits Mesenchymal Differentiation and Radioresistance in Glioblastoma.29373718Aldave G, Gonzalez-Huarriz M, Rubio A, Romero JP, Ravi D, Mi?ana B, Cuadrado-Tejedor M, Garc?a-Osta A, Verhaak R, Xipell E, Martinez-V?lez N, de la Rocha AA, Puigdelloses M, Garc?a-Moure M, Marigil M, G?llego P?rez-Larraya J, Mar?n-Bejar O, Huarte M, Carro MS, Ferrarese R, Belda-Iniesta C, Ayuso A, Prat-Ac?n R, Pastor F, D?ez-Valle R, Tejada S, Alonso MMNeuro-oncologyThe aberrant splicing of BAF45d links splicing regulation and transcription in glioblastoma. Neuro Oncol. 2018 06 18; 20(7):930-941.Neuro Oncol2018-06-18T00:00:002018The aberrant splicing of BAF45d links splicing regulation and transcription in glioblastoma.29594041Tejada S, D?ez-Valle R, Dom?nguez PD, Pati?o-Garc?a A, Gonz?lez-Huarriz M, Fueyo J, Gomez-Manzano C, Idoate MA, Peterkin J, Alonso MMFrontiers in oncologyDNX-2401, an Oncolytic Virus, for the Treatment of Newly Diagnosed Diffuse Intrinsic Pontine Gliomas: A Case Report. Front Oncol. 2018; 8:61.Front Oncol2018-03-12T00:00:002018DNX-2401, an Oncolytic Virus, for the Treatment of Newly Diagnosed Diffuse Intrinsic Pontine Gliomas: A Case Report.29226089Garcia-Moure M, Martinez-V?lez N, Pati?o-Garc?a A, Alonso MMJournal of bone oncologyOncolytic adenoviruses as a therapeutic approach for osteosarcoma: A new hope. J Bone Oncol. 2017 Nov; 9:41-47.J Bone Oncol2016-12-14T00:00:002016Oncolytic adenoviruses as a therapeutic approach for osteosarcoma: A new hope.29635349Fueyo J, Alonso MM, Parker Kerrigan BC, Gomez-Manzano CNeuro-oncologyLinking inflammation and cancer: the unexpected SYK world. Neuro Oncol. 2018 04 09; 20(5):582-583.Neuro Oncol2018-04-09T00:00:002018Linking inflammation and cancer: the unexpected SYK world.29987215Varela-Guruceaga M, Tejada-Sol?s S, Garc?a-Moure M, Fueyo J, Gomez-Manzano C, Pati?o-Garc?a A, Alonso MMCancersOncolytic Viruses as Therapeutic Tools for Pediatric Brain Tumors. Cancers (Basel). 2018 Jul 09; 10(7).Cancers (Basel)2018-07-09T00:00:002018Oncolytic Viruses as Therapeutic Tools for Pediatric Brain Tumors.30123426Gonz?lez-Morales A, Zabaleta A, Guruceaga E, Alonso MM, Garc?a-Moure M, Fern?ndez-Irigoyen J, Santamar?a EOncotargetSpatial and temporal proteome dynamics of glioma cells during oncolytic adenovirus Delta-24-RGD infection. Oncotarget. 2018 Jul 24; 9(57):31045-31065.Oncotarget2018-07-24T00:00:002018Spatial and temporal proteome dynamics of glioma cells during oncolytic adenovirus Delta-24-RGD infection.30019219Cavalli FMG, H?bner JM, Sharma T, Luu B, Sill M, Zapotocky M, Mack SC, Witt H, Lin T, Shih DJH, Ho B, Santi M, Emery L, Hukin J, Dunham C, McLendon RE, Lipp ES, Gururangan S, Grossbach A, French P, Kros JM, van Veelen MC, Rao AAN, Giannini C, Leary S, Jung S, Faria CC, Mora J, Sch?ller U, Alonso MM, Chan JA, Klekner A, Chambless LB, Hwang EI, Massimino M, Eberhart CG, Karajannis MA, Lu B, Liau LM, Zollo M, Ferrucci V, Carlotti C, Tirapelli DPC, Tabori U, Bouffet E, Ryzhova M, Ellison DW, Merchant TE, Gilbert MR, Armstrong TS, Korshunov A, Pfister SM, Taylor MD, Aldape K, Pajtler KW, Kool M, Ramaswamy VActa neuropathologicaHeterogeneity within the PF-EPN-B ependymoma subgroup. Acta Neuropathol. 2018 08; 136(2):227-237.Acta Neuropathol2018-07-17T00:00:002018Heterogeneity within the PF-EPN-B ependymoma subgroup.30221041Soldevilla MM, Villanueva H, Martinez-Velez N, Meraviglia-Crivelli D, Alonso MM, Cebollero J, Menon AP, Puigdelloses M, Pastor FOncoimmunologyIntratumoral injection of activated B lymphoblast in combination with PD-1 blockade induces systemic antitumor immunity with reduction of local and distal tumors. Oncoimmunology. 2018; 7(8):e1450711.Oncoimmunology2018-04-09T00:00:002018Intratumoral injection of activated B lymphoblast in combination with PD-1 blockade induces systemic antitumor immunity with reduction of local and distal tumors.30503830Gonz?lez-Morales A, Zabaleta A, Garc?a-Moure M, Alonso MM, Fern?ndez-Irigoyen J, Santamar?a EJournal of proteomicsOncolytic adenovirus Delta-24-RGD induces a widespread glioma proteotype remodeling during autophagy. J Proteomics. 2019 03 01; 194:168-178.J Proteomics2018-11-29T00:00:002018Oncolytic adenovirus Delta-24-RGD induces a widespread glioma proteotype remodeling during autophagy.D020295Disorders431080.892296Brain Stem NeoplasmsNeurosurgeryDepartment of MedicineDepartment of NeurosurgeryMedicine-Hematology & OncologyNeurosurgeryBaylor College of MedicineFREDERICKLANGFREDERICK LANG29.70706480000000-95.397162400000001037LANG, FREDERICKAdjunct ProfessorMASATAKASUZUKIMASATAKA SUZUKI29.70508570000000-95.401808700000001382SUZUKI, MASATAKAAssociate ProfessorAuthorship 941329730497448Collantes M, Mart?nez-V?lez N, Zalacain M, Marrod?n L, Ecay M, Garc?a-Velloso MJ, Alonso MM, Pati?o-Garc?a A, Pe?uelas IBMC cancerAssessment of metabolic patterns and new antitumoral treatment in osteosarcoma xenograft models by [18F]FDG and sodium [18F]fluoride PET. BMC Cancer. 2018 Nov 29; 18(1):1193.BMC Cancer2018-11-29T00:00:002018Assessment of metabolic patterns and new antitumoral treatment in osteosarcoma xenograft models by [18F]FDG and sodium [18F]fluoride PET.Authorship 946084931036068Martinez-Velez N, Marigil M, Garc?a-Moure M, Gonzalez-Huarriz M, Aristu JJ, Ramos-Garc?a LI, Tejada S, D?ez-Valle R, Pati?o-Garc?a A, Becher OJ, Gomez-Manzano C, Fueyo J, Alonso MMActa neuropathologica communicationsDelta-24-RGD combined with radiotherapy exerts a potent antitumor effect in diffuse intrinsic pontine glioma and pediatric high grade glioma models. Acta Neuropathol Commun. 2019 04 29; 7(1):64.Acta Neuropathol Commun2019-04-29T00:00:002019Delta-24-RGD combined with radiotherapy exerts a potent antitumor effect in diffuse intrinsic pontine glioma and pediatric high grade glioma models.Authorship 9479482031138805Mart?nez-V?lez N, Garcia-Moure M, Marigil M, Gonz?lez-Huarriz M, Puigdelloses M, Gallego P?rez-Larraya J, Zalaca?n M, Marrod?n L, Varela-Guruceaga M, Laspidea V, Aristu JJ, Ramos LI, Tejada-Sol?s S, D?ez-Valle R, Jones C, Mackay A, Mart?nez-Climent JA, Garc?a-Barchino MJ, Raabe E, Monje M, Becher OJ, Junier MP, El-Habr EA, Chneiweiss H, Aldave G, Jiang H, Fueyo J, Pati?o-Garc?a A, Gomez-Manzano C, Alonso MMNature communicationsThe oncolytic virus Delta-24-RGD elicits an antitumor effect in pediatric glioma and DIPG mouse models. Nat Commun. 2019 05 28; 10(1):2235.Nat Commun2019-05-28T00:00:002019The oncolytic virus Delta-24-RGD elicits an antitumor effect in pediatric glioma and DIPG mouse models.Authorship 954555931455679Jiang H, Shin DH, Nguyen TT, Fueyo J, Fan X, Henry V, Carrillo CC, Yi Y, Alonso MM, Collier TL, Yuan Y, Lang FF, Gomez-Manzano CClinical cancer research : an official journal of the American Association for Cancer ResearchLocalized Treatment with Oncolytic Adenovirus Delta-24-RGDOX Induces Systemic Immunity against Disseminated Subcutaneous and Intracranial Melanomas. Clin Cancer Res. 2019 11 15; 25(22):6801-6814.Clin Cancer Res2019-08-27T00:00:002019Localized Treatment with Oncolytic Adenovirus Delta-24-RGDOX Induces Systemic Immunity against Disseminated Subcutaneous and Intracranial Melanomas.Authorship 956839431591461Garcia-Moure M, Martinez-Velez N, Gonzalez-Huarriz M, Marrod?n L, Cascallo M, Alemany R, Pati?o-Garc?a A, Alonso MMScientific reportsThe oncolytic adenovirus VCN-01 promotes anti-tumor effect in primitive neuroectodermal tumor models. Sci Rep. 2019 10 07; 9(1):14368.Sci Rep2019-10-07T00:00:002019The oncolytic adenovirus VCN-01 promotes anti-tumor effect in primitive neuroectodermal tumor models.Authorship 957159931608328Rivera-Molina Y, Jiang H, Fueyo J, Nguyen T, Shin DH, Youssef G, Fan X, Gumin J, Alonso MM, Phadnis S, Lang FF, Gomez-Manzano CNeuro-oncology advancesGITRL-armed Delta-24-RGD oncolytic adenovirus prolongs survival and induces anti-glioma immune memory. Neurooncol Adv. 2019 May-Dec; 1(1):vdz009.Neurooncol Adv2019-06-05T00:00:002019GITRL-armed Delta-24-RGD oncolytic adenovirus prolongs survival and induces anti-glioma immune memory.true1Adjunct ProfessorAdjunct ProfessorAuthorship 993890532642678Puigdelloses M, Gonz?lez-Hu?rriz M, Garc?a-Moure M, Mart?nez-V?lez N, Esparragosa V?zquez I, Bruna J, Zandio B, Agirre A, Marigil M, Petrirena G, Nu?ez-C?rdoba JM, Tejada-Sol?s S, D?ez-Valle R, G?llego-Culler? J, Mart?nez-Vila E, Pati?o-Garc?a A, Alonso MM, G?llego P?rez-Larraya JNeuro-oncology advancesRNU6-1 in circulating exosomes differentiates GBM from non-neoplastic brain lesions and PCNSL but not from brain metastases. Neurooncol Adv. 2020 Jan-Dec; 2(1):vdaa010.Neurooncol Adv2020-01-31T00:00:002020RNU6-1 in circulating exosomes differentiates GBM from non-neoplastic brain lesions and PCNSL but not from brain metastases.Authorship 999227532905473de la Rocha AMA, Gonz?lez-Huarriz M, Guruceaga E, Mihelson N, Tejada-Sol?s S, D?ez-Valle R, Mart?nez-V?lez N, Fueyo J, Gomez-Manzano C, Alonso MM, Laterra J, L?pez-Bertoni HArchives of clinical and biomedical researchmiR-425-5p, a SOX2 target, regulates the expression of FOXJ3 and RAB31 and promotes the survival of GSCs. Arch Clin Biomed Res. 2020; 4(3):221-238.Arch Clin Biomed Res2020-06-18T00:00:002020miR-425-5p, a SOX2 target, regulates the expression of FOXJ3 and RAB31 and promotes the survival of GSCs.Authorship 1006615333294214Guti?rrez-Jimeno M, Panizo-Morgado E, Tamayo I, San Juli?n M, Catal?n-Lamb?n A, Alonso MM, Pati?o-Garc?a ANPJ genomic medicineSomatic and germline analysis of a familial Rothmund-Thomson syndrome in two siblings with osteosarcoma. NPJ Genom Med. 2020; 5:51.NPJ Genom Med2020-12-04T00:00:002020Somatic and germline analysis of a familial Rothmund-Thomson syndrome in two siblings with osteosarcoma.Authorship 10079322033376098Garcia-Moure M, Gonzalez-Huarriz M, Labiano S, Guruceaga E, Bandres E, Zalacain M, Marrodan L, de Andrea C, Villalba M, Martinez-Velez N, Laspidea V, Puigdelloses M, Gallego Perez-Larraya J, I?igo-Marco I, Stripecke R, Chan JA, Raabe EH, Kool M, Gomez-Manzano C, Fueyo J, Pati?o-Garc?a A, Alonso MMClinical cancer research : an official journal of the American Association for Cancer ResearchDelta-24-RGD, an Oncolytic Adenovirus, Increases Survival and Promotes Proinflammatory Immune Landscape Remodeling in Models of AT/RT and CNS-PNET. Clin Cancer Res. 2021 03 15; 27(6):1807-1820.Clin Cancer Res2020-12-29T00:00:002020Delta-24-RGD, an Oncolytic Adenovirus, Increases Survival and Promotes Proinflammatory Immune Landscape Remodeling in Models of AT/RT and CNS-PNET.Authorship 1011214733575468Zalacain M, Bunuales M, Marrodan L, Labiano S, Gonzalez-Huarriz M, Martinez-V?lez N, Laspidea V, Puigdelloses M, Garc?a-Moure M, Gonzalez-Aparicio M, Hernandez-Alcoceba R, Alonso MM, Pati?o-Garc?a AMolecular therapy oncolyticsLocal administration of IL-12 with an HC vector results in local and metastatic tumor control in pediatric osteosarcoma. Mol Ther Oncolytics. 2021 Mar 26; 20:23-33.Mol Ther Oncolytics2020-11-20T00:00:002020Local administration of IL-12 with an HC vector results in local and metastatic tumor control in pediatric osteosarcoma.Authorship 1015713533795384Shin DH, Nguyen T, Ozpolat B, Lang F, Alonso M, Gomez-Manzano C, Fueyo JJournal for immunotherapy of cancerCurrent strategies to circumvent the antiviral immunity to optimize cancer virotherapy. J Immunother Cancer. 2021 04; 9(4).J Immunother Cancer2021-04-01T00:00:002021Current strategies to circumvent the antiviral immunity to optimize cancer virotherapy.Authorship 1024363434214494Fueyo J, Gomez-Manzano C, Lang FF, Alonso MMThe Lancet. OncologyHitchhiking to brain tumours: stem cell delivery of oncolytic viruses. Lancet Oncol. 2021 08; 22(8):1049-1051.Lancet Oncol2021-06-29T00:00:002021Hitchhiking to brain tumours: stem cell delivery of oncolytic viruses.Authorship 1034056534771600Guti?rrez-Jimeno M, Alba-Pav?n P, Astigarraga I, Im?zcoz T, Panizo-Morgado E, Garc?a-Obreg?n S, Catal?n-Lamb?n A, San-Juli?n M, Lamo-Espinosa JM, Echebarria-Barona A, Zalacain M, Alonso MM, Pati?o-Garc?a ACancersClinical Value of NGS Genomic Studies for Clinical Management of Pediatric and Young Adult Bone Sarcomas. Cancers (Basel). 2021 Oct 29; 13(21).Cancers (Basel)2021-10-29T00:00:002021Clinical Value of NGS Genomic Studies for Clinical Management of Pediatric and Young Adult Bone Sarcomas.Authorship 1035179534888488de la Rocha AMA, Gonz?lez-Huarriz M, Guruceaga E, Mihelson N, Tejada-Sol?s S, D?ez-Valle R, Mart?nez-V?lez N, Fueyo J, Gomez-Manzano C, Alonso MM, Laterra J, L?pez-Bertoni HArchives of clinical and biomedical researchErratum: miR-425-5p, a SOX2 target, regulates the expression of FOXJ3 and RAB31 and promotes the survival of GSCs. Arch Clin Biomed Res. 2021; 5(3):425-426.Arch Clin Biomed Res2021-06-15T00:00:002021Erratum: miR-425-5p, a SOX2 target, regulates the expression of FOXJ3 and RAB31 and promotes the survival of GSCs.Authorship 10362651234965961Martinez-Velez N, Laspidea V, Zalacain M, Labiano S, Garc?a-Moure M, Puigdelloses M, Marrodan L, Gonzalez-Huarriz M, Herrador G, de la Nava D, Ausejo-Mauleon I, Fueyo J, Gomez-Manzano C, Pati?o-Garc?a A, Alonso MMMolecular cancer therapeuticsLocal Treatment of a Pediatric Osteosarcoma Model with a 4-1BBL Armed Oncolytic Adenovirus Results in an Antitumor Effect and Leads to Immune Memory. Mol Cancer Ther. 2022 03 01; 21(3):471-480.Mol Cancer Ther2022-03-01T00:00:002022Local Treatment of a Pediatric Osteosarcoma Model with a 4-1BBL Armed Oncolytic Adenovirus Results in an Antitumor Effect and Leads to Immune Memory.Authorship 1041112435216113Damanskiene E, Balnyte I, Valanciute A, Alonso MM, Preik?aitis A, Staki?aitis DInternational journal of molecular sciencesThe Different Temozolomide Effects on Tumorigenesis Mechanisms of Pediatric Glioblastoma PBT24 and SF8628 Cell Tumor in CAM Model and on Cells In Vitro. Int J Mol Sci. 2022 Feb 11; 23(4).Int J Mol Sci2022-02-11T00:00:002022The Different Temozolomide Effects on Tumorigenesis Mechanisms of Pediatric Glioblastoma PBT24 and SF8628 Cell Tumor in CAM Model and on Cells In Vitro.Authorship 104355017Authorship 1044634635393952Laspidea V, Puigdelloses M, Labiano S, Marrod?n L, Garcia-Moure M, Zalacain M, Gonzalez-Huarriz M, Mart?nez-V?lez N, Ausejo-Mauleon I, de la Nava D, Herrador-Ca?ete G, Marco-Sanz J, Guruceaga E, de Andrea CE, Villalba M, Becher O, Squatrito M, Mat?a V, G?llego P?rez-Larraya J, Pati?o-Garc?a A, Gupta S, Gomez-Manzano C, Fueyo J, Alonso MMJCI insightExploiting 4-1BB immune checkpoint to enhance the efficacy of oncolytic virotherapy for diffuse intrinsic pontine gliomas. JCI Insight. 2022 04 08; 7(7).JCI Insight2022-04-08T00:00:002022Exploiting 4-1BB immune checkpoint to enhance the efficacy of oncolytic virotherapy for diffuse intrinsic pontine gliomas.35481923Persson ML, Douglas AM, Alvaro F, Faridi P, Larsen MR, Alonso MM, Vitanza NA, Dun MDNeuro-oncologyThe intrinsic and microenvironmental features of diffuse midline glioma: Implications for the development of effective immunotherapeutic treatment strategies. Neuro Oncol. 2022 09 01; 24(9):1408-1422.Neuro Oncol2022-09-01T00:00:002022The intrinsic and microenvironmental features of diffuse midline glioma: Implications for the development of effective immunotherapeutic treatment strategies.Authorship 1044884335493490de la Nava D, Selvi KM, Alonso MMFrontiers in immunologyImmunovirotherapy for Pediatric Solid Tumors: A Promising Treatment That is Becoming a Reality. Front Immunol. 2022; 13:866892.Front Immunol2022-04-13T00:00:002022Immunovirotherapy for Pediatric Solid Tumors: A Promising Treatment That is Becoming a Reality.35767439G?llego P?rez-Larraya J, Garcia-Moure M, Labiano S, Pati?o-Garc?a A, Dobbs J, Gonzalez-Huarriz M, Zalacain M, Marrodan L, Martinez-Velez N, Puigdelloses M, Laspidea V, Astigarraga I, Lopez-Ibor B, Cruz O, Oscoz Lizarbe M, Hervas-Stubbs S, Alkorta-Aranburu G, Tamayo I, Tavira B, Hernandez-Alcoceba R, Jones C, Dharmadhikari G, Ruiz-Moreno C, Stunnenberg H, Hulleman E, van der Lugt J, Idoate M?, Diez-Valle R, Esparragosa V?zquez I, Villalba M, de Andrea C, N??ez-C?rdoba JM, Ewald B, Robbins J, Fueyo J, Gomez-Manzano C, Lang FF, Tejada S, Alonso MMThe New England journal of medicineOncolytic DNX-2401 Virus for Pediatric Diffuse Intrinsic Pontine Glioma. N Engl J Med. 2022 06 30; 386(26):2471-2481.N Engl J Med2022-06-30T00:00:002022Oncolytic DNX-2401 Virus for Pediatric Diffuse Intrinsic Pontine Glioma.35902132Nguyen TT, Shin DH, Sohoni S, Singh SK, Rivera-Molina Y, Jiang H, Fan X, Gumin J, Lang FF, Alvarez-Breckenridge C, Godoy-Vitorino F, Zhu L, Zheng WJ, Zhai L, Ladomersky E, Lauing KL, Alonso MM, Wainwright DA, Gomez-Manzano C, Fueyo JJournal for immunotherapy of cancerReshaping the tumor microenvironment with oncolytic viruses, positive regulation of the immune synapse, and blockade of the immunosuppressive oncometabolic circuitry. J Immunother Cancer. 2022 07; 10(7).J Immunother Cancer2022-07-01T00:00:002022Reshaping the tumor microenvironment with oncolytic viruses, positive regulation of the immune synapse, and blockade of the immunosuppressive oncometabolic circuitry.true1Visiting Assistant ProfessorVisiting Assistant ProfessorAuthorship 106913720Authorship 10701233Authorship 107095839Authorship 106917819Authorship 107013711Authorship 10694953Authorship 10705953036353934Basurco L, Abellanas MA, Ayerra L, Conde E, Vinueza-Gavilanes R, Luquin E, Vales A, Vilas A, Martin-Uriz PS, Tamayo I, Alonso MM, Hernaez M, Gonzalez-Aseguinolaza G, Clavero P, Mengual E, Arrasate M, Herv?s-Stubbs S, Aymerich MSGliaMicroglia and astrocyte activation is region-dependent in the a-synuclein mouse model of Parkinson's disease. Glia. 2023 Mar; 71(3):571-587.Glia2022-11-10T00:00:002022Microglia and astrocyte activation is region-dependent in the a-synuclein mouse model of Parkinson's disease.37188783Nassiri F, Patil V, Yefet LS, Singh O, Liu J, Dang RMA, Yamaguchi TN, Daras M, Cloughesy TF, Colman H, Kumthekar PU, Chen CC, Aiken R, Groves MD, Ong SS, Ramakrishna R, Vogelbaum MA, Khagi S, Kaley T, Melear JM, Peereboom DM, Rodriguez A, Yankelevich M, Nair SG, Puduvalli VK, Aldape K, Gao A, L?pez-Janeiro ?, de Andrea CE, Alonso MM, Boutros P, Robbins J, Mason WP, Sonabend AM, Stupp R, Fueyo J, Gomez-Manzano C, Lang FF, Zadeh GNature medicineOncolytic DNX-2401 virotherapy plus pembrolizumab in recurrent glioblastoma: a phase 1/2 trial. Nat Med. 2023 Jun; 29(6):1370-1378.Nat Med2023-05-15T00:00:002023Oncolytic DNX-2401 virotherapy plus pembrolizumab in recurrent glioblastoma: a phase 1/2 trial.37061388G?llego P?rez-Larraya J, Garc?a-Moure M, Alonso MMRevue neurologiqueOncolytic virotherapy for the treatment of pediatric brainstem gliomas. Rev Neurol (Paris). 2023 Jun; 179(5):475-480.Rev Neurol (Paris)2023-04-13T00:00:002023Oncolytic virotherapy for the treatment of pediatric brainstem gliomas.36321133Garcia-Moure M, Tallon-Cobos AC, Alonso MMMolecular therapy oncolyticsDNA-damaging cancer cells to improve virotherapy. Mol Ther Oncolytics. 2022 Dec 15; 27:124-125.Mol Ther Oncolytics2022-10-21T00:00:002022DNA-damaging cancer cells to improve virotherapy.35949950Herrador-Ca?ete G, Zalacain M, Labiano S, Laspidea V, Puigdelloses M, Marrodan L, Garcia-Moure M, Gonzalez-Huarriz M, Marco-Sanz J, Ausejo-Mauleon I, de la Nava D, Hern?ndez-Osuna R, Mart?nez-Garc?a J, Silva-Pilipich N, Gurucega E, Pati?o-Garc?a A, Hern?ndez-Alcoceba R, Smerdou C, Alonso MMMolecular therapy oncolyticsGalectin-3 inhibition boosts the therapeutic efficacy of Semliki Forest virus in pediatric osteosarcoma. Mol Ther Oncolytics. 2022 Sep 15; 26:246-264.Mol Ther Oncolytics2022-07-09T00:00:002022Galectin-3 inhibition boosts the therapeutic efficacy of Semliki Forest virus in pediatric osteosarcoma.true1Associate ProfessorAssociate ProfessorAuthorship 1079232237541723Herv?s-Corpi?n I, Alonso MMInternational review of cell and molecular biologyOncolytic viruses as treatment for adult and pediatric high-grade gliomas: On the way to clinical success. Int Rev Cell Mol Biol. 2023; 379:169-188.Int Rev Cell Mol Biol2023-04-26T00:00:002023Oncolytic viruses as treatment for adult and pediatric high-grade gliomas: On the way to clinical success.Authorship 10804933237802053Ausejo-Mauleon I, Labiano S, de la Nava D, Laspidea V, Zalacain M, Marrod?n L, Garc?a-Moure M, Gonz?lez-Huarriz M, Herv?s-Corpi?n I, Dhandapani L, Vicent S, Collantes M, Pe?uelas I, Becher OJ, Filbin MG, Jiang L, Labelle J, de Biagi-Junior CAO, Nazarian J, Laternser S, Phoenix TN, van der Lugt J, Kranendonk M, Hoogendijk R, Mueller S, De Andrea C, Anderson AC, Guruceaga E, Koschmann C, Yadav VN, G?llego P?rez-Larraya J, Pati?o-Garc?a A, Pastor F, Alonso MMCancer cellTIM-3 blockade in diffuse intrinsic pontine glioma models promotes tumor regression and antitumor immune memory. Cancer Cell. 2023 11 13; 41(11):1911-1926.e8.Cancer Cell2023-10-05T00:00:002023TIM-3 blockade in diffuse intrinsic pontine glioma models promotes tumor regression and antitumor immune memory.Authorship 1081270237820087Pati?o-Garc?a A, Alonso MM, G?llego P?rez-Larraya JCurrent opinion in oncologyPromises of oncolytic viral therapy for adult and children with brain glioma. Curr Opin Oncol. 2023 11 01; 35(6):529-535.Curr Opin Oncol2023-08-29T00:00:002023Promises of oncolytic viral therapy for adult and children with brain glioma.Authorship 1083792338039965Koschmann C, Al-Holou WN, Alonso MM, Anastas J, Bandopadhayay P, Barron T, Becher O, Cartaxo R, Castro MG, Chung C, Clausen M, Dang D, Doherty R, Duchatel R, Dun M, Filbin M, Franson A, Galban S, Garcia Moure M, Garton H, Gowda P, Marques JG, Hawkins C, Heath A, Hulleman E, Ji S, Jones C, Kilburn L, Kline C, Koldobskiy MA, Lim D, Lowenstein PR, Lu QR, Lum J, Mack S, Magge S, Marini B, Martin D, Marupudi N, Messinger D, Mody R, Morgan M, Mota M, Muraszko K, Mueller S, Natarajan SK, Nazarian J, Niculcea M, Nuechterlein N, Okada H, Opipari V, Pai MP, Pal S, Peterson E, Phoenix T, Prensner JR, Pun M, Raju GP, Reitman ZJ, Resnick A, Rogawski D, Saratsis A, Sbergio SG, Souweidane M, Stafford JM, Tzaridis T, Venkataraman S, Vittorio O, Wadden J, Wahl D, Wechsler-Reya RJ, Yadav VN, Zhang X, Zhang Q, Venneti SCancer cellA road map for the treatment of pediatric diffuse midline glioma. Cancer Cell. 2024 01 08; 42(1):1-5.Cancer Cell2023-11-30T00:00:002023A road map for the treatment of pediatric diffuse midline glioma.Authorship 1086177338159270Ausejo-Mauleon I, Labiano S, Alonso MMSTAR protocolsCharacterization of immune populations in the tumor microenvironment of diffuse midline glioma orthotopic mouse models by flow cytometry. STAR Protoc. 2024 Mar 15; 5(1):102803.STAR Protoc2023-12-29T00:00:002023Characterization of immune populations in the tumor microenvironment of diffuse midline glioma orthotopic mouse models by flow cytometry.Authorship 1087269338224193Ausejo-Mauleon I, Nuin S, Alonso MMClinical and translational medicineThe rise of TIM-3: A promising immune target in diffuse midline gliomas. Clin Transl Med. 2024 Jan; 14(1):e1536.Clin Transl Med2024-01-01T00:00:002024The rise of TIM-3: A promising immune target in diffuse midline gliomas.Authorship 10883331438311852Shin DH, Jiang H, Gillard AG, Kim D, Fan X, Singh SK, Nguyen TT, Sohoni SS, Lopez-Rivas AR, Parthasarathy A, Ene CI, Gumin J, Lang FF, Alonso MM, Gomez-Manzano C, Fueyo JMolecular therapy : the journal of the American Society of Gene TherapyChimeric oncolytic adenovirus evades neutralizing antibodies from human patients and exhibits enhanced anti-glioma efficacy in immunized mice. Mol Ther. 2024 Mar 06; 32(3):722-733.Mol Ther2024-02-03T00:00:002024Chimeric oncolytic adenovirus evades neutralizing antibodies from human patients and exhibits enhanced anti-glioma efficacy in immunized mice.true1ProfessorProfessortrue1ProfessorProfessortrue1Associate ProfessorAssociate Professortrue1Associate ProfessorAssociate Professortrue1ProfessorProfessor