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This is a "connection" page, showing publications co-authored by CHRIS AMOS and IVAN GORLOV.
CHRIS AMOS
Connection Strength
13.029
IVAN GORLOV
  1. Strength of selection in lung tumors correlates with clinical features better than tumor mutation burden. Sci Rep. 2024 06 03; 14(1):12732.
    View in: PubMed
    Score: 0.909
  2. Why does the X chromosome lag behind autosomes in GWAS findings? PLoS Genet. 2023 02; 19(2):e1010472.
    View in: PubMed
    Score: 0.833
  3. Tumor somatic mutations also existing as germline polymorphisms may help to identify functional SNPs from genome-wide association studies. Carcinogenesis. 2020 10 15; 41(10):1353-1362.
    View in: PubMed
    Score: 0.707
  4. SNP eQTL status and eQTL density in the adjacent region of the SNP are associated with its statistical significance in GWA studies. BMC Genet. 2019 11 12; 20(1):85.
    View in: PubMed
    Score: 0.663
  5. Untouchable genes in the human genome: Identifying ideal targets for cancer treatment. Cancer Genet. 2019 02; 231-232:67-79.
    View in: PubMed
    Score: 0.627
  6. Gene characteristics predicting missense, nonsense and frameshift mutations in tumor samples. BMC Bioinformatics. 2018 Nov 19; 19(1):430.
    View in: PubMed
    Score: 0.620
  7. Identification of gene expression levels in primary melanoma associated with clinically meaningful characteristics. Melanoma Res. 2018 10; 28(5):380-389.
    View in: PubMed
    Score: 0.614
  8. Allelic Spectra of Risk SNPs Are Different for Environment/Lifestyle Dependent versus Independent Diseases. PLoS Genet. 2015 Jul; 11(7):e1005371.
    View in: PubMed
    Score: 0.492
  9. SNP characteristics predict replication success in association studies. Hum Genet. 2014 Dec; 133(12):1477-86.
    View in: PubMed
    Score: 0.465
  10. How to get the most from microarray data: advice from reverse genomics. BMC Genomics. 2014 Mar 21; 15:223.
    View in: PubMed
    Score: 0.448
  11. Building a statistical model for predicting cancer genes. PLoS One. 2012; 7(11):e49175.
    View in: PubMed
    Score: 0.408
  12. Evolutionary evidence of the effect of rare variants on disease etiology. Clin Genet. 2011 Mar; 79(3):199-206.
    View in: PubMed
    Score: 0.351
  13. Relative effects of mutability and selection on single nucleotide polymorphisms in transcribed regions of the human genome. BMC Genomics. 2008 Jun 17; 9:292.
    View in: PubMed
    Score: 0.301
  14. Shifting paradigm of association studies: value of rare single-nucleotide polymorphisms. Am J Hum Genet. 2008 Jan; 82(1):100-12.
    View in: PubMed
    Score: 0.291
  15. Seizure 6-like (SEZ6L) gene and risk for lung cancer. Cancer Res. 2007 Sep 01; 67(17):8406-11.
    View in: PubMed
    Score: 0.285
  16. Strength of the purifying selection against different categories of the point mutations in the coding regions of the human genome. Hum Mol Genet. 2006 Apr 01; 15(7):1143-50.
    View in: PubMed
    Score: 0.256
  17. Predicting the oncogenicity of missense mutations reported in the International Agency for Cancer Research (IARC) mutation database on p53. Hum Mutat. 2005 Nov; 26(5):446-54.
    View in: PubMed
    Score: 0.251
  18. Exposure-inducible genes may contribute to missingness in RNAseq-based gene expression analyses. Sci Rep. 2025 Aug 22; 15(1):30889.
    View in: PubMed
    Score: 0.247
  19. Gene expression in tumor and adjacent normal tissues in lung adenocarcinoma subtypes. BMC Cancer. 2025 Jul 14; 25(1):1169.
    View in: PubMed
    Score: 0.246
  20. Missense mutations in cancer suppressor gene TP53 are colocalized with exonic splicing enhancers (ESEs). Mutat Res. 2004 Oct 04; 554(1-2):175-83.
    View in: PubMed
    Score: 0.233
  21. Lung Cancer in Ever- and Never-Smokers: Findings from Multi-Population GWAS Studies. Cancer Epidemiol Biomarkers Prev. 2024 03 01; 33(3):389-399.
    View in: PubMed
    Score: 0.223
  22. Missense mutations in hMLH1 and hMSH2 are associated with exonic splicing enhancers. Am J Hum Genet. 2003 Nov; 73(5):1157-61.
    View in: PubMed
    Score: 0.217
  23. Immune Infiltration in Tumor and Adjacent Non-Neoplastic Regions Codetermines Patient Clinical Outcomes in Early-Stage Lung Cancer. J Thorac Oncol. 2023 09; 18(9):1184-1198.
    View in: PubMed
    Score: 0.211
  24. Methylation of nonessential genes in cutaneous melanoma - Rule Out hypothesis. Melanoma Res. 2023 06 01; 33(3):163-172.
    View in: PubMed
    Score: 0.208
  25. Cross-ancestry genome-wide meta-analysis of 61,047 cases and 947,237 controls identifies new susceptibility loci contributing to lung cancer. Nat Genet. 2022 08; 54(8):1167-1177.
    View in: PubMed
    Score: 0.200
  26. Identification of lung cancer drivers by comparison of the observed and the expected numbers of missense and nonsense mutations in individual human genes. Oncotarget. 2022; 13:756-767.
    View in: PubMed
    Score: 0.198
  27. SNP characteristics and validation success in genome wide association studies. Hum Genet. 2022 Feb; 141(2):229-238.
    View in: PubMed
    Score: 0.192
  28. Human genes differ by their UV sensitivity estimated through analysis of UV-induced silent mutations in melanoma. Hum Mutat. 2020 10; 41(10):1751-1760.
    View in: PubMed
    Score: 0.174
  29. Ancestry inference using principal component analysis and spatial analysis: a distance-based analysis to account for population substructure. BMC Genomics. 2017 Oct 16; 18(1):789.
    View in: PubMed
    Score: 0.144
  30. Downstream targets of GWAS-detected genes for breast, lung, and prostate and colon cancer converge to G1/S transition pathway. Hum Mol Genet. 2017 04 15; 26(8):1465-1471.
    View in: PubMed
    Score: 0.139
  31. FastPop: a rapid principal component derived method to infer intercontinental ancestry using genetic data. BMC Bioinformatics. 2016 Mar 09; 17:122.
    View in: PubMed
    Score: 0.128
  32. Prediction of the gene expression in normal lung tissue by the gene expression in blood. BMC Med Genomics. 2015 Nov 17; 8:77.
    View in: PubMed
    Score: 0.126
  33. Genes with a large intronic burden show greater evolutionary conservation on the protein level. BMC Evol Biol. 2014 Mar 16; 14(1):50.
    View in: PubMed
    Score: 0.112
  34. Fine-mapping of the 5p15.33, 6p22.1-p21.31, and 15q25.1 regions identifies functional and histology-specific lung cancer susceptibility loci in African-Americans. Cancer Epidemiol Biomarkers Prev. 2013 Feb; 22(2):251-60.
    View in: PubMed
    Score: 0.103
  35. Multistage analysis of variants in the inflammation pathway and lung cancer risk in smokers. Cancer Epidemiol Biomarkers Prev. 2012 Jul; 21(7):1213-21.
    View in: PubMed
    Score: 0.098
  36. Derived SNP alleles are used more frequently than ancestral alleles as risk-associated variants in common human diseases. J Bioinform Comput Biol. 2012 Apr; 10(2):1241008.
    View in: PubMed
    Score: 0.098
  37. Novel genetic variants in the chromosome 5p15.33 region associate with lung cancer risk. Carcinogenesis. 2011 Oct; 32(10):1493-9.
    View in: PubMed
    Score: 0.093
  38. Nicotinic acetylcholine receptor region on chromosome 15q25 and lung cancer risk among African Americans: a case-control study. J Natl Cancer Inst. 2010 Aug 04; 102(15):1199-205.
    View in: PubMed
    Score: 0.086
  39. GWAS meets microarray: are the results of genome-wide association studies and gene-expression profiling consistent? Prostate cancer as an example. PLoS One. 2009 Aug 04; 4(8):e6511.
    View in: PubMed
    Score: 0.081
  40. Genome-wide association scan of tag SNPs identifies a susceptibility locus for lung cancer at 15q25.1. Nat Genet. 2008 May; 40(5):616-22.
    View in: PubMed
    Score: 0.074
  41. Stratifying Lung Adenocarcinoma Risk with Multi-ancestry Polygenic Risk Scores in East Asian Never-Smokers. medRxiv. 2025 Aug 24.
    View in: PubMed
    Score: 0.062
  42. Human genomic regions of systemic interindividual epigenetic variation are implicated in neurodevelopmental and metabolic disorders. medRxiv. 2025 Feb 12.
    View in: PubMed
    Score: 0.060
  43. DNA Methylation Classes of Stage II and III Primary Melanomas and Their Clinical and Prognostic Significance. JCO Precis Oncol. 2024 Nov; 8:e2400375.
    View in: PubMed
    Score: 0.059
  44. Identification of genetically predicted DNA methylation markers associated with non-small cell lung cancer risk among 34,964 cases and 448,579 controls. Cancer. 2024 03 15; 130(6):913-926.
    View in: PubMed
    Score: 0.055
  45. Genome-wide association study of lung adenocarcinoma in East Asia and comparison with a European population. Nat Commun. 2023 05 26; 14(1):3043.
    View in: PubMed
    Score: 0.053
  46. Mosaic Chromosomal Alterations Are Associated With Increased Lung Cancer Risk: Insight From the INTEGRAL-ILCCO Cohort Analysis. J Thorac Oncol. 2023 08; 18(8):1003-1016.
    View in: PubMed
    Score: 0.053
  47. Genome-wide interaction analysis identified low-frequency variants with sex disparity in lung cancer risk. Hum Mol Genet. 2022 08 23; 31(16):2831-2843.
    View in: PubMed
    Score: 0.050
  48. Landscape of mutations in early stage primary cutaneous melanoma: An InterMEL study. Pigment Cell Melanoma Res. 2022 11; 35(6):605-612.
    View in: PubMed
    Score: 0.050
  49. Protein-altering germline mutations implicate novel genes related to lung cancer development. Nat Commun. 2020 05 11; 11(1):2220.
    View in: PubMed
    Score: 0.043
  50. Association Analysis of Driver Gene-Related Genetic Variants Identified Novel Lung Cancer Susceptibility Loci with 20,871 Lung Cancer Cases and 15,971 Controls. Cancer Epidemiol Biomarkers Prev. 2020 07; 29(7):1423-1429.
    View in: PubMed
    Score: 0.043
  51. Lung Cancer Risk in Never-Smokers of European Descent is Associated With Genetic Variation in the 5p15.33 TERT-CLPTM1Ll Region. J Thorac Oncol. 2019 08; 14(8):1360-1369.
    View in: PubMed
    Score: 0.040
  52. Genetic interaction analysis among oncogenesis-related genes revealed novel genes and networks in lung cancer development. Oncotarget. 2019 Mar 05; 10(19):1760-1774.
    View in: PubMed
    Score: 0.040
  53. A Leukocyte Infiltration Score Defined by a Gene Signature Predicts Melanoma Patient Prognosis. Mol Cancer Res. 2019 01; 17(1):109-119.
    View in: PubMed
    Score: 0.038
  54. Identification of susceptibility pathways for the role of chromosome 15q25.1 in modifying lung cancer risk. Nat Commun. 2018 08 13; 9(1):3221.
    View in: PubMed
    Score: 0.038
  55. A Phenome-Wide Association Study Uncovers a Role for Autoimmunity in the Development of Chronic Obstructive Pulmonary Disease. Am J Respir Cell Mol Biol. 2018 06; 58(6):777-779.
    View in: PubMed
    Score: 0.037
  56. Gene-level association analysis of systemic sclerosis: A comparison of African-Americans and White populations. PLoS One. 2018; 13(1):e0189498.
    View in: PubMed
    Score: 0.036
  57. Cell cycle-related genes as modifiers of age of onset of colorectal cancer in Lynch syndrome: a large-scale study in non-Hispanic white patients. Carcinogenesis. 2013 Feb; 34(2):299-306.
    View in: PubMed
    Score: 0.025
  58. Association study of nicotinic acetylcholine receptor genes identifies a novel lung cancer susceptibility locus near CHRNA1 in African-Americans. Oncotarget. 2012 Nov; 3(11):1428-38.
    View in: PubMed
    Score: 0.025
  59. Variants in inflammation genes are implicated in risk of lung cancer in never smokers exposed to second-hand smoke. Cancer Discov. 2011 Oct; 1(5):420-9.
    View in: PubMed
    Score: 0.023
  60. Association of smoking with tumor size at diagnosis in non-small cell lung cancer. Lung Cancer. 2011 Dec; 74(3):378-83.
    View in: PubMed
    Score: 0.023
  61. Variants at IRF5-TNPO3, 17q12-21 and MMEL1 are associated with primary biliary cirrhosis. Nat Genet. 2010 Aug; 42(8):655-7.
    View in: PubMed
    Score: 0.022
Connection Strength

The connection strength for concepts is the sum of the scores for each matching publication.

Publication scores are based on many factors, including how long ago they were written and whether the person is a first or senior author.