BETTINAWEIGELINBETTINA WEIGELIN12404WEIGELIN, BETTINAInstructorprns:coAuthorOfcoauthor ofFaculty Rankprns:fullNamefull nameprns:hasAuthorListauthor listprns:hasFacultyRankhas faculty rankprns:hasNetworkhas networkprns:hasPublicationVenuepublished inprns:informationResourceReferenceinformation resource referenceprns:isPrimaryPositionis primary positionprns:latitudelatitudeprns:longitudelongitudeprns:mainImagephotoprns:maxWeightmaximum weightprns:medlineTAjournal title abbreviationprns:meshDescriptorUIMeSH DescriptorUIprns:meshSemanticGroupNameMeSH semantic group nameprns:minWeightminimum weightprns:numberOfAuthorsnumber of authorsprns:numberOfConnectionsnumber of connectionsprns:numberOfPublicationsnumber of publicationsprns:personIdPerson IDprns:personInPrimaryPositionperson in primary positionprns:positionInDepartmentposition in departmentprns:positionInDivisionposition in divisionprns:predicateNodepredicate nodeprns:publicationDatepublication dateprns:similarTosimilar toprns:sortOrdersort orderprns:uniquenessWeightuniqueness weightprns:yearyearAcademic ArticleArticleDocumentbibo:pmidPubMed IdentifierAddressvivo:address1address line 1vivo:addressCitycityvivo:addressPostalCodepostal codevivo:addressStatestate or provincevivo:authorInAuthorshipselected publicationsvivo:authorRankauthor rank in publicationAuthorshipDepartmentDivisionvivo:hasResearchArearesearch areasvivo:hrJobTitleHR job titleInformation Resourcevivo:linkedAuthorlinked authorvivo:linkedInformationResourcelinked information resourcevivo:mailingAddressmailing addressvivo:personInPositionpositionsPositionvivo:positionInOrganizationposition in organizationvivo:preferredTitlepreferred titlerdf:predicatepredicaterdf:typetyperdfs:labellabelConceptAgentfoaf:firstNamefirst namefoaf:lastNamelast nameOrganizationPerson18711433Friedl P, Weigelin BNature immunologyInterstitial leukocyte migration and immune function. Nat Immunol. 2008 Sep; 9(9):960-9.Nat Immunol2008-09-01T00:00:002008Interstitial leukocyte migration and immune function.22315137Bonetto F, Srinivas M, Weigelin B, Cruz LJ, Heerschap A, Friedl P, Figdor CG, de Vries IJNMR in biomedicineA large-scale (19)F MRI-based cell migration assay to optimize cell therapy. NMR Biomed. 2012 Sep; 25(9):1095-103.NMR Biomed2012-02-07T00:00:002012A large-scale (19)F MRI-based cell migration assay to optimize cell therapy.Genitourinary Medical OncologyMD AndersonPETERFRIEDLPETER FRIEDL9782FRIEDL, PETERProfessor20849829Weigelin B, Friedl PBiochemical pharmacologyA three-dimensional organotypic assay to measure target cell killing by cytotoxic T lymphocytes. Biochem Pharmacol. 2010 Dec 15; 80(12):2087-91.Biochem Pharmacol2010-09-16T00:00:002010A three-dimensional organotypic assay to measure target cell killing by cytotoxic T lymphocytes.21333682Weigelin B, Krause M, Friedl PImmunology lettersCytotoxic T lymphocyte migration and effector function in the tumor microenvironment. Immunol Lett. 2011 Jul; 138(1):19-21.Immunol Lett2011-02-17T00:00:002011Cytotoxic T lymphocyte migration and effector function in the tumor microenvironment.23896198Alexander S, Weigelin B, Winkler F, Friedl PCurrent opinion in cell biologyPreclinical intravital microscopy of the tumour-stroma interface: invasion, metastasis, and therapy response. Curr Opin Cell Biol. 2013 Oct; 25(5):659-71.Curr Opin Cell Biol2013-07-26T00:00:002013Preclinical intravital microscopy of the tumour-stroma interface: invasion, metastasis, and therapy response.25526299Friedl P, Weigelin BImmunityA Swiss Army knife for CTLs. Immunity. 2014 Dec 18; 41(6):873-5.Immunity2014-12-18T00:00:002014A Swiss Army knife for CTLs.26034288Weigelin B, Bola?os E, Teijeira A, Martinez-Forero I, Labiano S, Azpilikueta A, Morales-Kastresana A, Quetglas JI, Wagena E, S?nchez-Paulete AR, Chen L, Friedl P, Melero IProceedings of the National Academy of Sciences of the United States of AmericaFocusing and sustaining the antitumor CTL effector killer response by agonist anti-CD137 mAb. Proc Natl Acad Sci U S A. 2015 Jun 16; 112(24):7551-6.Proc Natl Acad Sci U S A2015-06-01T00:00:002015Focusing and sustaining the antitumor CTL effector killer response by agonist anti-CD137 mAb.26743082Weigelin B, Bakker GJ, Friedl PJournal of cell scienceThird harmonic generation microscopy of cells and tissue organization. J Cell Sci. 2016 Jan 15; 129(2):245-55.J Cell Sci2016-01-07T00:00:002016Third harmonic generation microscopy of cells and tissue organization.74Professor54Instructor42Director47Distinguished Service Professor1515 Holcombe BlvdHouston77030-4009TX2.75990.00783117140research areas5.924965.924961coauthor of38.22044.6661460similar to1130selected publicationsAuthorship 847469Authorship 849620Authorship 866674Journal of Cell ScienceThird harmonic generation microscopy of cells and tissue organization. Journal of Cell Science. 129:245-255.Third harmonic generation microscopy of cells and tissue organizationNature MaterialsCancer cells. Nature Materials. 15:827-828.Cancer cellsScienceNuclear envelope rupture and repair during cancer cell migration. Science. 352:353-358.Nuclear envelope rupture and repair during cancer cell migrationAuthorship 8863422Authorship 8863761Authorship 8864061Authorship 8867563Authorship 8869442Authorship 8870591Authorship 8872182Authorship 8876451D013602Anatomy27810150.661697T-Lymphocytes, CytotoxicD003602Physiology2426730.826121Cytotoxicity, ImmunologicD053261Chemicals & Drugs49690.934687Tumor Necrosis Factor Receptor Superfamily, Member 9Authorship 8992931D054353Chemicals & Drugs41520.96505PerforinAuthorship 9022866Authorship 9067231Authorship 9090391Authorship 9109736Authorship 9283891Authorship 937440221069257Hagemann C, Weigelin B, Schommer S, Schulze M, Al-Jomah N, Anacker J, Gerngras S, K?hnel S, Kessler AF, Polat B, Ernestus RI, Patel R, Vince GHInternational journal of molecular medicineThe cohesin-interacting protein, precocious dissociation of sisters 5A/sister chromatid cohesion protein 112, is up-regulated in human astrocytic tumors. Int J Mol Med. 2011 Jan; 27(1):39-51.Int J Mol Med2010-11-08T00:00:002010The cohesin-interacting protein, precocious dissociation of sisters 5A/sister chromatid cohesion protein 112, is up-regulated in human astrocytic tumors.25290882Cruz LJ, Tacken PJ, Zeelenberg IS, Srinivas M, Bonetto F, Weigelin B, Eich C, de Vries IJ, Figdor CGMolecular pharmaceuticsTracking targeted bimodal nanovaccines: immune responses and routing in cells, tissue, and whole organism. Mol Pharm. 2014 Dec 01; 11(12):4299-313.Mol Pharm2014-10-24T00:00:002014Tracking targeted bimodal nanovaccines: immune responses and routing in cells, tissue, and whole organism.26970765Weigelin B, Bola?os E, Rodriguez-Ruiz ME, Martinez-Forero I, Friedl P, Melero ICancer immunology, immunotherapy : CIIAnti-CD137 monoclonal antibodies and adoptive T cell therapy: a perfect marriage? Cancer Immunol Immunother. 2016 May; 65(5):493-7.Cancer Immunol Immunother2016-03-12T00:00:002016Anti-CD137 monoclonal antibodies and adoptive T cell therapy: a perfect marriage?27013428Denais CM, Gilbert RM, Isermann P, McGregor AL, te Lindert M, Weigelin B, Davidson PM, Friedl P, Wolf K, Lammerding JScience (New York, N.Y.)Nuclear envelope rupture and repair during cancer cell migration. Science. 2016 Apr 15; 352(6283):353-8.Science2016-03-24T00:00:002016Nuclear envelope rupture and repair during cancer cell migration.27443907Weigelin B, Friedl PNature materialsCancer cells: Stemness shaped by curvature. Nat Mater. 2016 07 22; 15(8):827-8.Nat Mater2016-07-22T00:00:002016Cancer cells: Stemness shaped by curvature.29607252Weigelin B, Bakker GJ, Friedl PIntravitalIntravital third harmonic generation microscopy of collective melanoma cell invasion: Principles of interface guidance and microvesicle dynamics. Intravital. 2012; 1(1):32-43.Intravital2012-07-01T00:00:002012Intravital third harmonic generation microscopy of collective melanoma cell invasion: Principles of interface guidance and microvesicle dynamics.30382086Huda S, Weigelin B, Wolf K, Tretiakov KV, Polev K, Wilk G, Iwasa M, Emami FS, Narojczyk JW, Banaszak M, Soh S, Pilans D, Vahid A, Makurath M, Friedl P, Borisy GG, Kandere-Grzybowska K, Grzybowski BANature communicationsL?vy-like movement patterns of metastatic cancer cells revealed in microfabricated systems and implicated in vivo. Nat Commun. 2018 10 31; 9(1):4539.Nat Commun2018-10-31T00:00:002018L?vy-like movement patterns of metastatic cancer cells revealed in microfabricated systems and implicated in vivo.Department of PediatricsPediatrics-Hem/Onc Cell & Gene ThePediatrics-Hematology & OncologyBaylor College of MedicineMALCOLMBRENNERMALCOLM BRENNER0.000000000000000.000000000000003564BRENNER, MALCOLMDistinguished Service ProfessorCLIONAROONEYCLIONA ROONEY0.000000000000000.000000000000003578ROONEY, CLIONAProfessorANNLEENANN LEEN0.000000000000000.00000000000000435LEEN, ANNProfessorAuthorship 941943430030697Fruhwirth GO, Kneilling M, de Vries IJM, Weigelin B, Srinivas M, Aarntzen EHJGMolecular imaging and biologyThe Potential of In Vivo Imaging for Optimization of Molecular and Cellular Anti-cancer Immunotherapies. Mol Imaging Biol. 2018 10; 20(5):696-704.Mol Imaging Biol2018-10-01T00:00:002018The Potential of In Vivo Imaging for Optimization of Molecular and Cellular Anti-cancer Immunotherapies.HELENHESLOPHELEN HESLOP0.000000000000000.000000000000003566HESLOP, HELENProfessorD00006941626330.950733Intravital Microscopytrue1ProfessorProfessortrue1Distinguished Service ProfessorDistinguished Service Professortrue1ProfessorProfessortrue1ProfessorProfessorAuthorship 1020128334073822Beck RJ, Weigelin B, Beltman JBCancersMathematical Modelling Based on In Vivo Imaging Suggests CD137-Stimulated Cytotoxic T Lymphocytes Exert Superior Tumour Control Due to an Enhanced Antimitotic Effect on Tumour Cells. Cancers (Basel). 2021 May 24; 13(11).Cancers (Basel)2021-05-24T00:00:002021Mathematical Modelling Based on In Vivo Imaging Suggests CD137-Stimulated Cytotoxic T Lymphocytes Exert Superior Tumour Control Due to an Enhanced Antimitotic Effect on Tumour Cells.Authorship 1024515834226201Slaats J, Dieteren CE, Wagena E, Wolf L, Raaijmakers TK, van der Laak JA, Figdor CG, Weigelin B, Friedl PCancer immunology researchMetabolic Screening of Cytotoxic T-cell Effector Function Reveals the Role of CRAC Channels in Regulating Lethal Hit Delivery. Cancer Immunol Res. 2021 08; 9(8):926-938.Cancer Immunol Res2021-07-05T00:00:002021Metabolic Screening of Cytotoxic T-cell Effector Function Reveals the Role of CRAC Channels in Regulating Lethal Hit Delivery.Authorship 1025556234274700Giampetraglia M, Weigelin BCurrent opinion in chemical biologyRecent advances in intravital microscopy for preclinical research. Curr Opin Chem Biol. 2021 08; 63:200-208.Curr Opin Chem Biol2021-07-15T00:00:002021Recent advances in intravital microscopy for preclinical research.Authorship 1028871134471116Weigelin B, den Boer AT, Wagena E, Broen K, Dolstra H, de Boer RJ, Figdor CG, Textor J, Friedl PNature communicationsCytotoxic T cells are able to efficiently eliminate cancer cells by additive cytotoxicity. Nat Commun. 2021 09 01; 12(1):5217.Nat Commun2021-09-01T00:00:002021Cytotoxic T cells are able to efficiently eliminate cancer cells by additive cytotoxicity.Authorship 10346781734853305Hinterleitner C, Str?hle J, Malenke E, Hinterleitner M, Henning M, Seehawer M, Bilich T, Heitmann J, Lutz M, Mattern S, Scheuermann S, Horger M, Maurer S, Walz J, Fend F, Handgretinger R, Seitz C, Weigelin B, Singer S, Salih H, Borst O, Kopp HG, Zender LNature communicationsPlatelet PD-L1 reflects collective intratumoral PD-L1 expression and predicts immunotherapy response in non-small cell lung cancer. Nat Commun. 2021 12 01; 12(1):7005.Nat Commun2021-12-01T00:00:002021Platelet PD-L1 reflects collective intratumoral PD-L1 expression and predicts immunotherapy response in non-small cell lung cancer.Authorship 1038544435303206Fruhwirth GO, Weigelin B, Daldrup-Link HE, Ponomarev VMolecular imaging and biologyEditorial to the Special Issue Entitled "Imaging in Immunooncology". Mol Imaging Biol. 2022 04; 24(2):177-180.Mol Imaging Biol2022-04-01T00:00:002022Editorial to the Special Issue Entitled "Imaging in Immunooncology".Authorship 10573041Authorship 1062200835965200Weigelin B, Friedl PTrends in cancerT cell-mediated additive cytotoxicity - death by multiple bullets. Trends Cancer. 2022 Dec; 8(12):980-987.Trends Cancer2022-08-11T00:00:002022T cell-mediated additive cytotoxicity - death by multiple bullets.36162129Slaats J, Wagena E, Smits D, Berends AA, Peters E, Bakker GJ, van Erp M, Weigelin B, Adema GJ, Friedl PCancer immunology researchAdenosine A2a Receptor Antagonism Restores Additive Cytotoxicity by Cytotoxic T Cells in Metabolically Perturbed Tumors. Cancer Immunol Res. 2022 12 02; 10(12):1462-1474.Cancer Immunol Res2022-12-02T00:00:002022Adenosine A2a Receptor Antagonism Restores Additive Cytotoxicity by Cytotoxic T Cells in Metabolically Perturbed Tumors.Authorship 1077983837733587Focken J, Scheurer J, J?ger A, Sch?rch CM, K?mereit S, Riel S, Schaller M, Weigelin B, Schittek BCell reportsNeutrophil extracellular traps enhance S. aureus skin colonization by oxidative stress induction and downregulation of epidermal barrier genes. Cell Rep. 2023 10 31; 42(10):113148.Cell Rep2023-09-19T00:00:002023Neutrophil extracellular traps enhance S. aureus skin colonization by oxidative stress induction and downregulation of epidermal barrier genes.Authorship 1087612738251799Scheurer J, Sauer B, Focken J, Giampetraglia M, J?ger A, Sch?rch CM, Weigelin B, Schittek BDisease models & mechanismsHistological and functional characterization of 3D human skin models mimicking the inflammatory skin diseases psoriasis and atopic dermatitis. Dis Model Mech. 2024 Jan 01; 17(1).Dis Model Mech2024-01-01T00:00:002024Histological and functional characterization of 3D human skin models mimicking the inflammatory skin diseases psoriasis and atopic dermatitis.Authorship 1088306738308817Bowden GD, Stotz S, Dunkel G, Haas S, Kimmerle E, Schaller M, Weigelin B, Herfert K, Pichler BJ, Maurer ABioconjugate chemistry[18F]pFBC, a Covalent CLIP-Tag Radiotracer for Detection of Viral Reporter Gene Transfer in the Murine Brain. Bioconjug Chem. 2024 02 21; 35(2):254-264.Bioconjug Chem2024-02-03T00:00:002024[18F]pFBC, a Covalent CLIP-Tag Radiotracer for Detection of Viral Reporter Gene Transfer in the Murine Brain.true1InstructorInstructortrue1ProfessorProfessor