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ROOPA THAPAR

TitleAssistant Professor
InstitutionMD Anderson
DepartmentMolecular & Cellular Oncology
Address6767 Bertner St
Houston TX 77030-2603
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    Publications listed below are automatically derived from MEDLINE/PubMed and other sources, which might result in incorrect or missing publications. Faculty can login to make corrections and additions.
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    PMC Citations indicate the number of times the publication was cited by articles in PubMed Central, and the Altmetric score represents citations in news articles and social media. (Note that publications are often cited in additional ways that are not shown here.) Fields are based on how the National Library of Medicine (NLM) classifies the publication's journal and might not represent the specific topic of the publication. Translation tags are based on the publication type and the MeSH terms NLM assigns to the publication. Some publications (especially newer ones and publications not in PubMed) might not yet be assigned Field or Translation tags.) Click a Field or Translation tag to filter the publications.
    1. Chinnam NB, Thapar R, Arvai AS, Sarker AH, Soll JM, Paul T, Syed A, Rosenberg DJ, Hammel M, Bacolla A, Katsonis P, Asthana A, Tsai MS, Ivanov I, Lichtarge O, Silverman RH, Mosammaparast N, Tsutakawa SE, Tainer JA. ASCC1 structures and bioinformatics reveal a novel helix-clasp-helix RNA-binding motif linked to a two-histidine phosphodiesterase. J Biol Chem. 2024 Jun; 300(6):107368. PMID: 38750793; PMCID: PMC11214414.
      Citations:    Fields:    Translation:HumansCells
    2. Thapar R, Hammel M, Ye R, Liang K, Sun C, Hnizda A, Liang S, Maw SS, Lee L, Villarreal H, Forrester I, Fang S, Tsai MS, Blundell TL, Davis AJ, Lin C, Lees-Miller SP, Tainer JA, Wang JL, Strick TR. Mechanism of efficient double-strand break repair by a long non-coding RNA. Nucleic Acids Res. 2021 01 25; 49(2):1199-1200. PMID: 33337499; PMCID: PMC7826246.
      Citations: 5     Fields:    
    3. Thapar R, Ye R, Liang K, Sun C, Hnizda A, Liang S, Maw SS, Lee L, Villarreal H, Forrester I, Fang S, Tsai MS, Blundell TL, Davis AJ, Lin C, Lees-Miller SP, Tainer JA, Wang JL, Hammel M, Strick TR. Mechanism of efficient double-strand break repair by a long non-coding RNA. Nucleic Acids Res. 2020 11 04; 48(19):10953-10972. PMID: 33045735; PMCID: PMC7641761.
      Citations: 19     Fields:    Translation:HumansCells
    4. Hammel M, Rosenberg DJ, Bierma J, Hura GL, Thapar R, Lees-Miller SP, Tainer JA. Visualizing functional dynamicity in the DNA-dependent protein kinase holoenzyme DNA-PK complex by integrating SAXS with cryo-EM. Prog Biophys Mol Biol. 2021 08; 163:74-86. PMID: 32966823; PMCID: PMC8896507.
      Citations: 7     Fields:    Translation:Cells
    5. Thapar R, Bacolla A, Oyeniran C, Brickner JR, Chinnam NB, Mosammaparast N, Tainer JA. RNA Modifications: Reversal Mechanisms and Cancer. Biochemistry. 2019 02 05; 58(5):312-329. PMID: 30346748.
      Citations: 19     Fields:    Translation:HumansCells
    6. Thapar R. Regulation of DNA Double-Strand Break Repair by Non-Coding RNAs. Molecules. 2018 Oct 27; 23(11). PMID: 30373256; PMCID: PMC6278438.
      Citations:    
    7. Thapar R. Structural basis for regulation of RNA-binding proteins by phosphorylation. ACS Chem Biol. 2015 Mar 20; 10(3):652-66. PMID: 25535763; PMCID: PMC4372107.
      Citations: 19     Fields:    Translation:HumansAnimalsCells
    8. Thapar R, Titus MA. Recent Advances in Metabolic Profiling And Imaging of Prostate Cancer. Curr Metabolomics. 2014 Apr; 2(1):53-69. PMID: 25632377; PMCID: PMC4306198.
      Citations: 12     
    9. Krishnan N, Titus MA, Thapar R. The prolyl isomerase pin1 regulates mRNA levels of genes with short half-lives by targeting specific RNA binding proteins. PLoS One. 2014; 9(1):e85427. PMID: 24416409; PMCID: PMC3887067.
      Citations: 19     Fields:    Translation:HumansCells
    10. Thapar R, Denmon AP, Nikonowicz EP. Recognition modes of RNA tetraloops and tetraloop-like motifs by RNA-binding proteins. Wiley Interdiscip Rev RNA. 2014 Jan-Feb; 5(1):49-67. PMID: 24124096; PMCID: PMC3867596.
      Citations: 27     Fields:    Translation:HumansAnimalsCells
    11. Thapar R, Denmon AP. Signaling pathways that control mRNA turnover. Cell Signal. 2013 Aug; 25(8):1699-710. PMID: 23602935; PMCID: PMC3703460.
      Citations: 17     Fields:    Translation:HumansCells
    12. Bansal N, Zhang M, Bhaskar A, Itotia P, Lee E, Shlyakhtenko LS, Lam TT, Fritz A, Berezney R, Lyubchenko YL, Stafford WF, Thapar R. Assembly of the SLIP1-SLBP complex on histone mRNA requires heterodimerization and sequential binding of SLBP followed by SLIP1. Biochemistry. 2013 Jan 22; 52(3):520-36. PMID: 23286197; PMCID: PMC3580866.
      Citations: 11     Fields:    Translation:HumansCells
    13. Krishnan N, Lam TT, Fritz A, Rempinski D, O'Loughlin K, Minderman H, Berezney R, Marzluff WF, Thapar R. The prolyl isomerase Pin1 targets stem-loop binding protein (SLBP) to dissociate the SLBP-histone mRNA complex linking histone mRNA decay with SLBP ubiquitination. Mol Cell Biol. 2012 Nov; 32(21):4306-22. PMID: 22907757; PMCID: PMC3486140.
      Citations: 28     Fields:    Translation:HumansCells
    14. Zhang M, Lam TT, Tonelli M, Marzluff WF, Thapar R. Interaction of the histone mRNA hairpin with stem-loop binding protein (SLBP) and regulation of the SLBP-RNA complex by phosphorylation and proline isomerization. Biochemistry. 2012 Apr 17; 51(15):3215-31. PMID: 22439849; PMCID: PMC3328597.
      Citations: 25     Fields:    Translation:HumansAnimalsCells
    15. Contribution of protein phosphorylation to binding-induced folding of the SLBP-histone mRNA complex probed by phosphorus-31 NMR. FEBS Open Bio. 4:853-857.
    16. DSF Guided Refolding As A Novel Method Of Protein Production. Scientific Reports. 6.
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