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PREMA ROBINSON

TitleAssociate Professor
InstitutionMD Anderson
DepartmentInfectious Diseases, Infection Control, and Employee Health
Address6767 Bertner St
Houston TX 77030-2603
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    Collapse Research 
    Collapse research activities and funding
    75N91019D00     (DATTA, KIRAN)Jun 1, 2023 - Sep 21, 2028
    NIH
    PHASE 1 AND PHASE 2 CLINICAL TRIALS FOR NEXT-GENERATION CORONAVIRUS VACCINES
    Role: Co-Principal Investigator
    R03AI099405     (ROBINSON, PREMA)Aug 6, 2013 - Jul 31, 2016
    NIH
    Role of STAT3 in the pathogenesis of Inflammatory Bowel Disease
    Role: Principal Investigator
    R21AI054205     (ROBINSON, PREMA)Jun 5, 2003 - May 31, 2006
    NIH
    Substance P in pathogenesis of cryptosporidiosis in AIDS
    Role: Principal Investigator
    R01NS042604     (ROBINSON, PREMA)Jun 1, 2003 - May 31, 2010
    NIH
    Neuropeptides in the pathogenesis of neurocysticercosis
    Role: Principal Investigator

    Collapse Bibliographic 
    Collapse selected publications
    Publications listed below are automatically derived from MEDLINE/PubMed and other sources, which might result in incorrect or missing publications. Faculty can login to make corrections and additions.
    Newest   |   Oldest   |   Most Cited   |   Most Discussed   |   Timeline   |   Field Summary   |   Plain Text
    PMC Citations indicate the number of times the publication was cited by articles in PubMed Central, and the Altmetric score represents citations in news articles and social media. (Note that publications are often cited in additional ways that are not shown here.) Fields are based on how the National Library of Medicine (NLM) classifies the publication's journal and might not represent the specific topic of the publication. Translation tags are based on the publication type and the MeSH terms NLM assigns to the publication. Some publications (especially newer ones and publications not in PubMed) might not yet be assigned Field or Translation tags.) Click a Field or Translation tag to filter the publications.
    1. Cove?as R, Rodr?guez FD, Robinson P, Mu?oz M. The Repurposing of Non-Peptide Neurokinin-1 Receptor Antagonists as Antitumor Drugs: An Urgent Challenge for Aprepitant. Int J Mol Sci. 2023 Nov 03; 24(21). PMID: 37958914; PMCID: PMC10650658.
      Citations: 1     Fields:    Translation:Humans
    2. Robinson P, Montoya K, Magness E, Rodriguez E, Villalobos V, Engineer N, Yang P, Bharadwaj U, Eckols TK, Tweardy DJ. Therapeutic Potential of a Small-Molecule STAT3 Inhibitor in a Mouse Model of Colitis. Cancers (Basel). 2023 May 30; 15(11). PMID: 37296943; PMCID: PMC10251885.
      Citations:    
    3. Robinson P, Rosso M, Mu?oz M. Neurokinin-1 Receptor Antagonists as a Potential Novel Therapeutic Option for Osteosarcoma Patients. J Clin Med. 2023 Mar 09; 12(6). PMID: 36983138; PMCID: PMC10058854.
      Citations:    
    4. Cove?as R, Mu?oz M, Robinson P. Combination Therapy of Chemotherapy or Radiotherapy and the Neurokinin-1 Receptor Antagonist Aprepitant: A New Antitumor Strategy? Curr Med Chem. 2023; 30(16):1798-1812. PMID: 35959620.
      Citations:    
    5. Robinson P, Magness E, Montoya K, Engineer N, Eckols TK, Rodriguez E, Tweardy DJ. Genetic and Small-Molecule Modulation of Stat3 in a Mouse Model of Crohn's Disease. J Clin Med. 2022 Nov 28; 11(23). PMID: 36498596.
      Citations: 3     
    6. Robinson P, Rodriguez E, Mu?oz M. Substance P-Friend or Foe. J Clin Med. 2022 Jun 22; 11(13). PMID: 35806893; PMCID: PMC9267209.
      Citations:    
    7. Rodriguez E, Pei G, Zhao Z, Kim ST, German A, Robinson P. Erratum: Rodriguez et al. Substance P Antagonism as a Novel Therapeutic Option to Enhance Efficacy of Cisplatin in Triple Negative Breast Cancer and Protect PC12 Cells against Cisplatin-Induced Oxidative Stress and Apoptosis. Cancers 2021, 13, 3871. Cancers (Basel). 2021 Oct 15; 13(20). PMID: 34680400; PMCID: PMC8533910.
      Citations:    
    8. Rodriguez E, Pei G, Kim ST, German A, Robinson P. Substance P Antagonism as a Novel Therapeutic Option to Enhance Efficacy of Cisplatin in Triple Negative Breast Cancer and Protect PC12 Cells against Cisplatin-Induced Oxidative Stress and Apoptosis. Cancers (Basel). 2021 Jul 31; 13(15). PMID: 34359773; PMCID: PMC8345440.
      Citations: 2     
    9. Legi A, Rodriguez E, Eckols TK, Mistry C, Robinson P. Substance P Antagonism Prevents Chemotherapy-Induced Cardiotoxicity. Cancers (Basel). 2021 Apr 06; 13(7). PMID: 33917491; PMCID: PMC8038801.
      Citations: 5     
    10. Wurster S, Robinson P, Albert ND, Tarrand JJ, Goff M, Swamydas M, Lim JK, Lionakis MS, Kontoyiannis DP. Protective Activity of Programmed Cell Death Protein 1 Blockade and Synergy With Caspofungin in a Murine Invasive Pulmonary Aspergillosis Model. J Infect Dis. 2020 08 17; 222(6):989-994. PMID: 32432714; PMCID: PMC7430165.
      Citations: 8     Fields:    Translation:Animals
    11. Bharadwaj U, Kasembeli MM, Robinson P, Tweardy DJ. Targeting Janus Kinases and Signal Transducer and Activator of Transcription 3 to Treat Inflammation, Fibrosis, and Cancer: Rationale, Progress, and Caution. Pharmacol Rev. 2020 04; 72(2):486-526. PMID: 32198236; PMCID: PMC7300325.
      Citations: 51     Fields:    Translation:HumansAnimalsCells
    12. Kasembeli MM, Bharadwaj U, Robinson P, Tweardy DJ. Contribution of STAT3 to Inflammatory and Fibrotic Diseases and Prospects for its Targeting for Treatment. Int J Mol Sci. 2018 Aug 05; 19(8). PMID: 30081609; PMCID: PMC6121470.
      Citations: 41     Fields:    Translation:HumansAnimals
    13. Robinson P, Kasembeli M, Bharadwaj U, Engineer N, Eckols KT, Tweardy DJ. Substance P Receptor Signaling Mediates Doxorubicin-Induced Cardiomyocyte Apoptosis and Triple-Negative Breast Cancer Chemoresistance. Biomed Res Int. 2016; 2016:1959270. PMID: 26981525; PMCID: PMC4766315.
      Citations: 17     Fields:    Translation:HumansAnimalsCells
    14. Khumbatta M, Firozgary B, Tweardy DJ, Weinstock J, Firozgary G, Bhatena Z, Bulsara T, Siller R, Robinson P. Corrigendum to "Somatostatin Negatively Regulates Parasite Burden and Granulomatous Responses in Cysticercosis". Biomed Res Int. 2015; 2015:869648. PMID: 26078968; PMCID: PMC4452501.
      Citations:    Fields:    
    15. Robinson P, Taffet GE, Engineer N, Khumbatta M, Firozgary B, Reynolds C, Pham T, Bulsara T, Firozgary G. Substance P receptor antagonism: a potential novel treatment option for viral-myocarditis. Biomed Res Int. 2015; 2015:645153. PMID: 25821814; PMCID: PMC4363507.
      Citations: 5     Fields:    Translation:Animals
    16. Khumbatta M, Firozgary B, Tweardy DJ, Weinstock J, Firozgary G, Bhatena Z, Bulsara T, Siller R, Robinson P. Somatostatin negatively regulates parasite burden and granulomatous responses in cysticercosis. Biomed Res Int. 2014; 2014:247182. PMID: 25530957; PMCID: PMC4121154.
      Citations: 1     Fields:    Translation:HumansAnimals
    17. Thacker SA, Robinson P, Abel A, Tweardy DJ. Modulation of the unfolded protein response during hepatocyte and cardiomyocyte apoptosis in trauma/hemorrhagic shock. Sci Rep. 2013; 3:1187. PMID: 23378918; PMCID: PMC3561621.
      Citations: 8     Fields:    Translation:AnimalsCells
    18. Robinson P, Garza A, Weinstock J, Serpa JA, Goodman JC, Eckols KT, Firozgary B, Tweardy DJ. Substance P causes seizures in neurocysticercosis. PLoS Pathog. 2012 Feb; 8(2):e1002489. PMID: 22346746; PMCID: PMC3276565.
      Citations: 19     Fields:    Translation:HumansAnimals
    19. Garza A, Tweardy DJ, Weinstock J, Viswanathan B, Robinson P. Substance P signaling contributes to granuloma formation in Taenia crassiceps infection, a murine model of cysticercosis. J Biomed Biotechnol. 2010; 2010:597086. PMID: 20150970; PMCID: PMC2817809.
      Citations: 11     Fields:    Translation:AnimalsCells
    20. Robinson P, Garza A, Moore J, Eckols TK, Parti S, Balaji V, Vallejo J, Tweardy DJ. Substance P is required for the pathogenesis of EMCV infection in mice. Int J Clin Exp Med. 2009; 2(1):76-86. PMID: 19436834; PMCID: PMC2680056.
      Citations: 20     
    21. Garza A, Weinstock J, Robinson P. Absence of the SP/SP receptor circuitry in the substance P-precursor knockout mice or SP receptor, neurokinin (NK)1 knockout mice leads to an inhibited cytokine response in granulomas associated with murine Taenia crassiceps infection. J Parasitol. 2008 Dec; 94(6):1253-8. PMID: 18576810; PMCID: PMC2647574.
      Citations: 14     Fields:    Translation:AnimalsCells
    22. Robinson P, Martin P, Garza A, D'Souza M, Mastrangelo MA, Tweardy D. Substance P receptor antagonism for treatment of cryptosporidiosis in immunosuppressed mice. J Parasitol. 2008 Oct; 94(5):1150-4. PMID: 18576802.
      Citations: 4     Fields:    Translation:AnimalsCells
    23. Garza A, Lackner A, Aye P, D'Souza M, Martin P, Borda J, Tweardy DJ, Weinstock J, Griffiths J, Robinson P. Substance P receptor antagonist reverses intestinal pathophysiological alterations occurring in a novel ex-vivo model of Cryptosporidium parvum infection of intestinal tissues derived from SIV-infected macaques. J Med Primatol. 2008 Jun; 37(3):109-15. PMID: 18547256.
      Citations: 2     Fields:    Translation:AnimalsCells
    24. Garza A, Castellanos-Gonzalez A, Castenallos-Gonzalez A, Griffiths J, Robinson P. Infection of immunocompetent mice with acid-water-pretreated Cryptosporidium parvum results in weight loss, and intestinal (structural and physiological) alterations. Parasitol Res. 2008 Feb; 102(3):457-63. PMID: 18040720.
      Citations:    Fields:    Translation:AnimalsCells
    25. Pantenburg B, Dann SM, Wang HC, Robinson P, Castellanos-Gonzalez A, Lewis DE, White AC. Intestinal immune response to human Cryptosporidium sp. infection. Infect Immun. 2008 Jan; 76(1):23-9. PMID: 17967863; PMCID: PMC2223661.
      Citations: 29     Fields:    Translation:HumansAnimals
    26. D'Souza M, Garza MA, Xie M, Weinstock J, Xiang Q, Robinson P. Substance P is associated with heart enlargement and apoptosis in murine dilated cardiomyopathy induced by Taenia crassiceps infection. J Parasitol. 2007 Oct; 93(5):1121-7. PMID: 18163347.
      Citations: 14     Fields:    Translation:HumansAnimals
    27. Hernandez J, Lackner A, Aye P, Mukherjee K, Tweardy DJ, Mastrangelo MA, Weinstock J, Griffiths J, D'Souza M, Dixit S, Robinson P. Substance P is responsible for physiological alterations such as increased chloride ion secretion and glucose malabsorption in cryptosporidiosis. Infect Immun. 2007 Mar; 75(3):1137-43. PMID: 17158891; PMCID: PMC1828596.
      Citations: 10     Fields:    Translation:Animals
    28. Patil S, Robinson P, Actor JK, Baig S, White AC. Proinflammatory cytokines in granulomas associated with murine cysticercosis are not the cause of seizures. J Parasitol. 2006 Aug; 92(4):738-41. PMID: 16995390.
      Citations: 5     Fields:    Translation:Animals
    29. Dann SM, Wang HC, Gambarin KJ, Actor JK, Robinson P, Lewis DE, Caillat-Zucman S, White AC. Interleukin-15 activates human natural killer cells to clear the intestinal protozoan cryptosporidium. J Infect Dis. 2005 Oct 01; 192(7):1294-302. PMID: 16136475.
      Citations: 28     Fields:    Translation:HumansAnimalsCells
    30. Okhuysen PC, Chappell CL, Lewis DE, Robinson P, White AC. Treatment of chronic cryptosporidiosis in AIDS with rIL-12 induces an immune response associated with improvement but severe side-effects. AIDS. 2005 Aug 12; 19(12):1333-4. PMID: 16052094.
      Citations: 1     Fields:    Translation:Humans
    31. Kumar A, Murphy R, Robinson P, Wei L, Boriek AM. Cyclic mechanical strain inhibits skeletal myogenesis through activation of focal adhesion kinase, Rac-1 GTPase, and NF-kappaB transcription factor. FASEB J. 2004 Oct; 18(13):1524-35. PMID: 15466361.
      Citations: 38     Fields:    Translation:AnimalsCells
    32. Stringer JL, Marks LM, White AC, Robinson P. Epileptogenic activity of granulomas associated with murine cysticercosis. Exp Neurol. 2003 Oct; 183(2):532-6. PMID: 14552894.
      Citations: 14     Fields:    Translation:Animals
    33. White AC, Robinson P, Okhuysen PC. Human studies provide insight into the pathogenesis, immunology, and treatment of cryptosporidiosis. Clin Infect Dis. 2003 Oct 01; 37(7):989; author reply 989-90. PMID: 13130414.
      Citations: 1     Fields:    Translation:HumansAnimals
    34. Robinson P, Okhuysen PC, Chappell CL, Weinstock JV, Lewis DE, Actor JK, White AC. Substance P expression correlates with severity of diarrhea in cryptosporidiosis. J Infect Dis. 2003 Jul 15; 188(2):290-6. PMID: 12854086.
      Citations: 11     Fields:    Translation:HumansAnimals
    35. Robinson P, White AC, Lewis DE, Thornby J, David E, Weinstock J. Sequential expression of the neuropeptides substance P and somatostatin in granulomas associated with murine cysticercosis. Infect Immun. 2002 Aug; 70(8):4534-8. PMID: 12117965; PMCID: PMC128166.
      Citations: 15     Fields:    Translation:Animals
    36. Robinson P, Okhuysen PC, Chappell CL, Lewis DE, Shahab I, Lahoti S, White AC. Expression of IL-15 and IL-4 in IFN-gamma-independent control of experimental human Cryptosporidium parvum infection. Cytokine. 2001 Jul 07; 15(1):39-46. PMID: 11509007.
      Citations: 11     Fields:    Translation:HumansAnimals
    37. Okhuysen PC, Robinson P, Nguyen MT, Nannini EC, Lewis DE, Janecki A, Chappell CL, White AC. Jejunal cytokine response in AIDS patients with chronic cryptosporidiosis and during immune reconstitution. AIDS. 2001 Apr 13; 15(6):802-4. PMID: 11371698.
      Citations: 5     Fields:    Translation:HumansCTClinical Trials
    38. Robinson P, Okhuysen PC, Chappell CL, Lewis DE, Shahab I, Janecki A, White AC. Expression of tumor necrosis factor alpha and interleukin 1 beta in jejuna of volunteers after experimental challenge with Cryptosporidium parvum correlates with exposure but not with symptoms. Infect Immun. 2001 Feb; 69(2):1172-4. PMID: 11160015; PMCID: PMC97999.
      Citations: 11     Fields:    Translation:HumansAnimals
    39. Robinson P, Okhuysen PC, Chappell CL, Lewis DE, Shahab I, Lahoti S, White AC. Transforming growth factor beta1 is expressed in the jejunum after experimental Cryptosporidium parvum infection in humans. Infect Immun. 2000 Sep; 68(9):5405-7. PMID: 10948171; PMCID: PMC101805.
      Citations: 10     Fields:    Translation:HumansAnimals
    40. White AC, Robinson P, Okhuysen PC, Lewis DE, Shahab I, Lahoti S, DuPont HL, Chappell CL. Interferon-gamma expression in jejunal biopsies in experimental human cryptosporidiosis correlates with prior sensitization and control of oocyst excretion. J Infect Dis. 2000 Feb; 181(2):701-9. PMID: 10669358.
      Citations: 22     Fields:    Translation:HumansAnimals
    41. Robinson P, Atmar RL, Lewis DE, White AC. Granuloma cytokines in murine cysticercosis. Infect Immun. 1997 Jul; 65(7):2925-31. PMID: 9199468; PMCID: PMC175410.
      Citations: 22     Fields:    Translation:AnimalsCells
    42. White AC, Robinson P, Kuhn R. Taenia solium cysticercosis: host-parasite interactions and the immune response. Chem Immunol. 1997; 66:209-30. PMID: 9103671.
      Citations: 42     Fields:    Translation:HumansAnimalsPHPublic Health
    43. White AC, Baig S, Robinson P. Taenia saginata oncosphere excretory/secretory peptidases. J Parasitol. 1996 Feb; 82(1):7-10. PMID: 8627504.
      Citations: 5     Fields:    Translation:HumansAnimalsCells
    44. Infection of immunocompetent mice with acid-water-pretreated Cryptosporidium parvum results in weight loss, and intestinal (structural and physiological) alterations (Parasitology Research DOI 10.1007/s00436-007-0785-3). Parasitology Research. 102:567.
    45. Erratum. BioMed Research International. 2015.
    46. Intestinal tnfa in cryptosporidiosis. Journal of Investigative Medicine. 44.
    47. Substance P Receptor Signaling Mediates Doxorubicin-Induced Cardiomyocyte Apoptosis and Triple-Negative Breast Cancer Chemoresistance. BioMed Research International. 2016.
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