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UDDALAK BHARADWAJ

TitleAssistant Professor
InstitutionMD Anderson
DepartmentInfectious Diseases, Infection Control, and Employee Health
Address6767 Bertner St
Houston TX 77030-2603
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    Publications listed below are automatically derived from MEDLINE/PubMed and other sources, which might result in incorrect or missing publications. Faculty can login to make corrections and additions.
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    PMC Citations indicate the number of times the publication was cited by articles in PubMed Central, and the Altmetric score represents citations in news articles and social media. (Note that publications are often cited in additional ways that are not shown here.) Fields are based on how the National Library of Medicine (NLM) classifies the publication's journal and might not represent the specific topic of the publication. Translation tags are based on the publication type and the MeSH terms NLM assigns to the publication. Some publications (especially newer ones and publications not in PubMed) might not yet be assigned Field or Translation tags.) Click a Field or Translation tag to filter the publications.
    1. Kumaresan PR, Wurster S, Bavisi K, da Silva TA, Hauser P, Kinnitt J, Albert ND, Bharadwaj U, Neelapu S, Kontoyiannis DP. A novel lentiviral vector-based approach to generate chimeric antigen receptor T cells targeting Aspergillus fumigatus. mBio. 2024 Apr 10; 15(4):e0341323. PMID: 38415653; PMCID: PMC11005356.
      Citations:    Fields:    
    2. Robinson P, Montoya K, Magness E, Rodriguez E, Villalobos V, Engineer N, Yang P, Bharadwaj U, Eckols TK, Tweardy DJ. Therapeutic Potential of a Small-Molecule STAT3 Inhibitor in a Mouse Model of Colitis. Cancers (Basel). 2023 May 30; 15(11). PMID: 37296943; PMCID: PMC10251885.
      Citations:    
    3. Kasembeli MM, Kaparos E, Bharadwaj U, Allaw A, Khouri A, Acot B, Tweardy DJ. Aberrant function of pathogenic STAT3 mutant proteins is linked to altered stability of monomers and homodimers. Blood. 2023 03 23; 141(12):1411-1424. PMID: 36240433; PMCID: PMC10651785.
      Citations: 2     Fields:    Translation:Cells
    4. Wurster S, Albert ND, Bharadwaj U, Kasembeli MM, Tarrand JJ, Daver N, Kontoyiannis DP. Blockade of the PD-1/PD-L1 Immune Checkpoint Pathway Improves Infection Outcomes and Enhances Fungicidal Host Defense in a Murine Model of Invasive Pulmonary Mucormycosis. Front Immunol. 2022; 13:838344. PMID: 35251033; PMCID: PMC8896628.
      Citations:    Fields:    Translation:Animals
    5. Kong R, Bharadwaj U, Eckols TK, Kolosov M, Wu H, Cruz-Pavlovich FJS, Shaw A, Ifelayo OI, Zhao H, Kasembeli MM, Wong STC, Tweardy DJ. Novel STAT3 small-molecule inhibitors identified by structure-based virtual ligand screening incorporating SH2 domain flexibility. Pharmacol Res. 2021 07; 169:105637. PMID: 33932608; PMCID: PMC8217378.
      Citations:    Fields:    Translation:HumansCells
    6. Bharadwaj U, Kasembeli MM, Robinson P, Tweardy DJ. Targeting Janus Kinases and Signal Transducer and Activator of Transcription 3 to Treat Inflammation, Fibrosis, and Cancer: Rationale, Progress, and Caution. Pharmacol Rev. 2020 04; 72(2):486-526. PMID: 32198236; PMCID: PMC7300325.
      Citations: 51     Fields:    Translation:HumansAnimalsCells
    7. Sharma M, Khong H, Fa'ak F, Bentebibel SE, Janssen LME, Chesson BC, Creasy CA, Kahn LMS, Pazdrak B, Karki B, Hailemichael Y, Singh M, Vianden C, Vennam S, Bharadwaj U, Tweardy DJ, Haymaker C, Bernatchez C, Huang S, Rajapakshe K, Coarfa C, Hurwitz ME, Sznol M, Hwu P, Hoch U, Addepalli M, Charych DH, Zalevsky J, Diab A, Overwijk WW, Forget MA. Bempegaldesleukin selectively depletes intratumoral Tregs and potentiates T cell-mediated cancer therapy. Nat Commun. 2020 01 31; 11(1):661. PMID: 32005826; PMCID: PMC6994577.
      Citations: 40     Fields:    Translation:HumansAnimalsCellsCTClinical Trials
    8. Bharadwaj U, Eckols TK, Xu X, Kasembeli MM, Chen Y, Adachi M, Song Y, Mo Q, Lai SY, Tweardy DJ. Correction: Small-molecule inhibition of STAT3 in radioresistant head and neck squamous cell carcinoma. Oncotarget. 2019 02 22; 10(16):1603. PMID: 30899429; PMCID: PMC6422187.
      Citations: 1     Fields:    
    9. Kasembeli MM, Bharadwaj U, Robinson P, Tweardy DJ. Contribution of STAT3 to Inflammatory and Fibrotic Diseases and Prospects for its Targeting for Treatment. Int J Mol Sci. 2018 Aug 05; 19(8). PMID: 30081609; PMCID: PMC6121470.
      Citations: 41     Fields:    Translation:HumansAnimals
    10. Economides MP, Amit M, Mahale PS, Hosry JJ, Jiang Y, Bharadwaj U, Sturgis EM, Torres HA. Impact of chronic hepatitis C virus infection on the survival of patients with oropharyngeal cancer. Cancer. 2018 03 01; 124(5):960-965. PMID: 29149493; PMCID: PMC5821521.
      Citations: 3     Fields:    Translation:HumansCells
    11. Singh M, Vianden C, Cantwell MJ, Dai Z, Xiao Z, Sharma M, Khong H, Jaiswal AR, Faak F, Hailemichael Y, Janssen LME, Bharadwaj U, Curran MA, Diab A, Bassett RL, Tweardy DJ, Hwu P, Overwijk WW. Intratumoral CD40 activation and checkpoint blockade induces T cell-mediated eradication of melanoma in the brain. Nat Commun. 2017 11 13; 8(1):1447. PMID: 29129918; PMCID: PMC5682289.
      Citations: 37     Fields:    Translation:AnimalsCells
    12. Jung KH, Yoo W, Stevenson HL, Deshpande D, Shen H, Gagea M, Yoo SY, Wang J, Eckols TK, Bharadwaj U, Tweardy DJ, Beretta L. Multifunctional Effects of a Small-Molecule STAT3 Inhibitor on NASH and Hepatocellular Carcinoma in Mice. Clin Cancer Res. 2017 Sep 15; 23(18):5537-5546. PMID: 28533225; PMCID: PMC5873583.
      Citations: 28     Fields:    Translation:HumansAnimalsCells
    13. Bharadwaj U, Eckols TK, Xu X, Kasembeli MM, Chen Y, Adachi M, Song Y, Mo Q, Lai SY, Tweardy DJ. Small-molecule inhibition of STAT3 in radioresistant head and neck squamous cell carcinoma. Oncotarget. 2016 May 03; 7(18):26307-30. PMID: 27027445; PMCID: PMC5041982.
      Citations: 38     Fields:    Translation:HumansAnimalsCells
    14. Robinson P, Kasembeli M, Bharadwaj U, Engineer N, Eckols KT, Tweardy DJ. Substance P Receptor Signaling Mediates Doxorubicin-Induced Cardiomyocyte Apoptosis and Triple-Negative Breast Cancer Chemoresistance. Biomed Res Int. 2016; 2016:1959270. PMID: 26981525; PMCID: PMC4766315.
      Citations: 17     Fields:    Translation:HumansAnimalsCells
    15. Yuan H, Houck KL, Tian Y, Bharadwaj U, Hull K, Zhou Z, Zhu M, Zhou M, Wu X, Tweardy DJ, Romo D, Fu X, Zhang Y, Zhang J, Dong JF. Piperlongumine Blocks JAK2-STAT3 to Inhibit Collagen-Induced Platelet Reactivity Independent of Reactive Oxygen Species. PLoS One. 2015; 10(12):e0143964. PMID: 26645674; PMCID: PMC4672935.
      Citations: 8     Fields:    Translation:Humans
    16. Lewis KM, Bharadwaj U, Eckols TK, Kolosov M, Kasembeli MM, Fridley C, Siller R, Tweardy DJ. Small-molecule targeting of signal transducer and activator of transcription (STAT) 3 to treat non-small cell lung cancer. Lung Cancer. 2015 Nov; 90(2):182-90. PMID: 26410177; PMCID: PMC4619129.
      Citations: 18     Fields:    Translation:HumansAnimalsCells
    17. Bharadwaj U, Kasembeli MM, Eckols TK, Kolosov M, Lang P, Christensen K, Edwards DP, Tweardy DJ. Monoclonal Antibodies Specific for STAT3? Reveal Its Contribution to Constitutive STAT3 Phosphorylation in Breast Cancer. Cancers (Basel). 2014 Sep 29; 6(4):2012-34. PMID: 25268166; PMCID: PMC4276954.
      Citations: 6     
    18. Prakash S, Alam S, Bharadwaj U, Aggarwal A, Mishra RN, Agrawal S. Associations of killer cell immunoglobulin like receptors with rheumatoid arthritis among North Indian population. Hum Immunol. 2014 Aug; 75(8):802-7. PMID: 24912006.
      Citations: 7     Fields:    Translation:HumansCells
    19. Marin-Muller C, Li D, Bharadwaj U, Li M, Chen C, Hodges SE, Fisher WE, Mo Q, Hung MC, Yao Q. A tumorigenic factor interactome connected through tumor suppressor microRNA-198 in human pancreatic cancer. Clin Cancer Res. 2013 Nov 01; 19(21):5901-13. PMID: 23989979; PMCID: PMC3920728.
      Citations: 43     Fields:    Translation:HumansAnimalsCells
    20. Elsarraj HS, Hong Y, Valdez K, Carletti M, Salah SM, Raimo M, Taverna D, Prochasson P, Bharadwaj U, Tweardy DJ, Christenson LK, Behbod F. A novel role of microRNA146b in promoting mammary alveolar progenitor cell maintenance. J Cell Sci. 2013 Jun 01; 126(Pt 11):2446-58. PMID: 23572509; PMCID: PMC3679487.
      Citations: 9     Fields:    Translation:AnimalsCells
    21. Bharadwaj U, Marin-Muller C, Li M, Chen C, Yao Q. Mesothelin confers pancreatic cancer cell resistance to TNF-a-induced apoptosis through Akt/PI3K/NF-?B activation and IL-6/Mcl-1 overexpression. Mol Cancer. 2011 Aug 31; 10:106. PMID: 21880146; PMCID: PMC3175472.
      Citations: 55     Fields:    Translation:HumansCells
    22. Bharadwaj U, Marin-Muller C, Li M, Chen C, Yao Q. Mesothelin overexpression promotes autocrine IL-6/sIL-6R trans-signaling to stimulate pancreatic cancer cell proliferation. Carcinogenesis. 2011 Jul; 32(7):1013-24. PMID: 21515913; PMCID: PMC3128561.
      Citations: 43     Fields:    Translation:HumansCells
    23. Lay MK, Atmar RL, Guix S, Bharadwaj U, He H, Neill FH, Sastry KJ, Yao Q, Estes MK. Norwalk virus does not replicate in human macrophages or dendritic cells derived from the peripheral blood of susceptible humans. Virology. 2010 Oct 10; 406(1):1-11. PMID: 20667573; PMCID: PMC2933743.
      Citations: 50     Fields:    Translation:HumansAnimalsCells
    24. Zhang Y, Bharadwaj U, Logsdon CD, Chen C, Yao Q, Li M. ZIP4 regulates pancreatic cancer cell growth by activating IL-6/STAT3 pathway through zinc finger transcription factor CREB. Clin Cancer Res. 2010 Mar 01; 16(5):1423-30. PMID: 20160059; PMCID: PMC2841320.
      Citations: 43     Fields:    Translation:HumansAnimalsCells
    25. Li M, Zhang Y, Bharadwaj U, Zhai QJ, Ahern CH, Fisher WE, Brunicardi FC, Logsdon CD, Chen C, Yao Q. Down-regulation of ZIP4 by RNA interference inhibits pancreatic cancer growth and increases the survival of nude mice with pancreatic cancer xenografts. Clin Cancer Res. 2009 Oct 01; 15(19):5993-6001. PMID: 19755388; PMCID: PMC2756333.
      Citations: 53     Fields:    Translation:HumansAnimalsCells
    26. Li M, Marin-Muller C, Bharadwaj U, Chow KH, Yao Q, Chen C. MicroRNAs: control and loss of control in human physiology and disease. World J Surg. 2009 Apr; 33(4):667-84. PMID: 19030926; PMCID: PMC2933043.
      Citations: 76     Fields:    Translation:Humans
    27. Bharadwaj U, Li M, Chen C, Yao Q. Mesothelin-induced pancreatic cancer cell proliferation involves alteration of cyclin E via activation of signal transducer and activator of transcription protein 3. Mol Cancer Res. 2008 Nov; 6(11):1755-65. PMID: 19010822; PMCID: PMC2929833.
      Citations: 49     Fields:    Translation:HumansCells
    28. Chen C, Chai H, Wang X, Jiang J, Jamaluddin MS, Liao D, Zhang Y, Wang H, Bharadwaj U, Zhang S, Li M, Lin P, Yao Q. Soluble CD40 ligand induces endothelial dysfunction in human and porcine coronary artery endothelial cells. Blood. 2008 Oct 15; 112(8):3205-16. PMID: 18658029; PMCID: PMC2569174.
      Citations: 31     Fields:    Translation:HumansAnimalsCells
    29. Li M, Bharadwaj U, Zhang R, Zhang S, Mu H, Fisher WE, Brunicardi FC, Chen C, Yao Q. Mesothelin is a malignant factor and therapeutic vaccine target for pancreatic cancer. Mol Cancer Ther. 2008 Feb; 7(2):286-96. PMID: 18281514; PMCID: PMC2929838.
      Citations: 90     Fields:    Translation:HumansAnimalsCells
    30. Wang X, Liao D, Bharadwaj U, Li M, Yao Q, Chen C. C-reactive protein inhibits cholesterol efflux from human macrophage-derived foam cells. Arterioscler Thromb Vasc Biol. 2008 Mar; 28(3):519-26. PMID: 18096828; PMCID: PMC2927966.
      Citations: 24     Fields:    Translation:HumansCells
    31. Li M, Zhang Y, Liu Z, Bharadwaj U, Wang H, Wang X, Zhang S, Liuzzi JP, Chang SM, Cousins RJ, Fisher WE, Brunicardi FC, Logsdon CD, Chen C, Yao Q. Aberrant expression of zinc transporter ZIP4 (SLC39A4) significantly contributes to human pancreatic cancer pathogenesis and progression. Proc Natl Acad Sci U S A. 2007 Nov 20; 104(47):18636-41. PMID: 18003899; PMCID: PMC2141829.
      Citations: 127     Fields:    Translation:HumansAnimalsCells
    32. Feurino LW, Zhang Y, Bharadwaj U, Zhang R, Li F, Fisher WE, Brunicardi FC, Chen C, Yao Q, Min L. IL-6 stimulates Th2 type cytokine secretion and upregulates VEGF and NRP-1 expression in pancreatic cancer cells. Cancer Biol Ther. 2007 Jul; 6(7):1096-100. PMID: 17568185.
      Citations: 46     Fields:    Translation:HumansCells
    33. Bharadwaj U, Li M, Zhang R, Chen C, Yao Q. Elevated interleukin-6 and G-CSF in human pancreatic cancer cell conditioned medium suppress dendritic cell differentiation and activation. Cancer Res. 2007 Jun 01; 67(11):5479-88. PMID: 17545630.
      Citations: 65     Fields:    Translation:HumansCells
    34. Yao Q, Doan LX, Zhang R, Bharadwaj U, Li M, Chen C. Thymosin-alpha1 modulates dendritic cell differentiation and functional maturation from human peripheral blood CD14+ monocytes. Immunol Lett. 2007 Jun 15; 110(2):110-20. PMID: 17532057; PMCID: PMC1986709.
      Citations: 9     Fields:    Translation:HumansCells
    35. Zhang R, Bharadwaj U, Li M, Chen C, Yao Q. Effects of pentoxifylline on differentiation, maturation, and function of human CD14+ monocyte-derived dendritic cells. J Immunother. 2007 Jan; 30(1):89-95. PMID: 17198087.
      Citations: 2     Fields:    Translation:HumansCells
    36. Aggarwal BB, Banerjee S, Bharadwaj U, Sung B, Shishodia S, Sethi G. Curcumin induces the degradation of cyclin E expression through ubiquitin-dependent pathway and up-regulates cyclin-dependent kinase inhibitors p21 and p27 in multiple human tumor cell lines. Biochem Pharmacol. 2007 Apr 01; 73(7):1024-32. PMID: 17240359.
      Citations: 38     Fields:    Translation:HumansCells
    37. Feurino LW, Fisher WE, Bharadwaj U, Yao Q, Chen C, Li M. Current update of cytokines in pancreatic cancer: pathogenic mechanisms, clinical indication, and therapeutic values. Cancer Invest. 2006 Nov; 24(7):696-703. PMID: 17118780.
      Citations: 8     Fields:    Translation:HumansAnimals
    38. Li M, Zhai Q, Bharadwaj U, Wang H, Li F, Fisher WE, Chen C, Yao Q. Cyclophilin A is overexpressed in human pancreatic cancer cells and stimulates cell proliferation through CD147. Cancer. 2006 May 15; 106(10):2284-94. PMID: 16604531.
      Citations: 65     Fields:    Translation:HumansCells
    39. Bharadwaj U, Zhang R, Yang H, Li M, Doan LX, Chen C, Yao Q. Effects of cyclophilin A on myeloblastic cell line KG-1 derived dendritic like cells (DLC) through p38 MAP kinase activation. J Surg Res. 2005 Jul 01; 127(1):29-38. PMID: 15964302.
      Citations: 7     Fields:    Translation:HumansCells
    40. Agrawal S, Bharadwaj U, Bhatnagar S, Sharma A, Khan F, Agarwal SS, M?ller B. Microsatellite variation at 24 STR loci in three endogamous groups of Uttar Pradesh, India. Hum Biol. 2003 Feb; 75(1):97-104. PMID: 12713150.
      Citations: 3     Fields:    Translation:HumansCells
    41. Agrawal S, Bharadwaj U, Bhatnagar S, Khan F, M?ller B. Evaluation of six short tandem repeat loci in forensics: north Indian populations. J Forensic Sci. 2002 May; 47(3):686-9. PMID: 12051367.
      Citations: 1     Fields:    Translation:HumansCells
    42. Agrawal S, Bharadwaj U, Bhatnagar S, Khan F, M?ller B. Allele frequencies of microsatellite repeat loci in Bhargavas, Chaturvedis, and Brahmins of North India. J Forensic Sci. 2002 May; 47(3):678-81. PMID: 12051365.
      Citations: 1     Fields:    Translation:HumansCells
    43. Agrawal S, Bharadwaj U, Bhatnagar S, Khan F, M?ller B. Distribution of allele frequencies of six STR markers in north Indians. J Forensic Sci. 2002 May; 47(3):682-5. PMID: 12051366.
      Citations: 2     Fields:    Translation:HumansCells
    44. Significance of human leukocyte antigens in immunobiology of renal transplantation. Current Science. 78:974-988.
    45. Monoclonal antibodies specific for Stat3β reveal its contribution to constitutive Stat3 phosphorylation in breast cancer. Cancers. 6:2012-2034.
    46. STAT3 inhibition prevents lung inflammation, remodeling, and accumulation of Th2 and Th17 cells in a murine asthma model. Allergy: European Journal of Allergy and Clinical Immunology.
    47. Mieap-regulated mitochondrial quality control is frequently inactivated in human colorectal cancer. Oncogenesis. 5:e181.
    48. Erratum. PLoS One. 11.
    49. Substance P Receptor Signaling Mediates Doxorubicin-Induced Cardiomyocyte Apoptosis and Triple-Negative Breast Cancer Chemoresistance. BioMed Research International. 2016.
    50. Small-molecule inhibition of STAT3 in radioresistant head and neck squamous cell carcinoma. Oncotarget. 7:26307-26330.
    51. Small-molecule targeting of signal transducer and activator of transcription (STAT) 3 to treat non-small cell lung cancer. Lung Cancer.
    52. Erratum. Biochemical Pharmacology. 102:147.
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