SHELDONCHENSHELDON CHEN11921CHEN, SHELDONAssociate Professorprns:coAuthorOfcoauthor ofFaculty Rankprns:fullNamefull nameprns:hasAuthorListauthor listprns:hasFacultyRankhas faculty rankprns:hasNetworkhas networkprns:hasPublicationVenuepublished inprns:informationResourceReferenceinformation resource referenceprns:isPrimaryPositionis primary positionprns:latitudelatitudeprns:longitudelongitudeprns:mainImagephotoprns:maxWeightmaximum weightprns:medlineTAjournal title abbreviationprns:meshDescriptorUIMeSH DescriptorUIprns:meshSemanticGroupNameMeSH semantic group nameprns:minWeightminimum weightprns:numberOfAuthorsnumber of authorsprns:numberOfConnectionsnumber of connectionsprns:numberOfPublicationsnumber of publicationsprns:personIdPerson IDprns:personInPrimaryPositionperson in primary positionprns:positionInDepartmentposition in departmentprns:positionInDivisionposition in divisionprns:predicateNodepredicate nodeprns:publicationDatepublication dateprns:similarTosimilar toprns:sortOrdersort orderprns:uniquenessWeightuniqueness weightprns:yearyearAcademic ArticleArticleDocumentbibo:pmidPubMed IdentifierAddressvivo:address1address line 1vivo:addressCitycityvivo:addressPostalCodepostal codevivo:addressStatestate or provincevivo:authorInAuthorshipselected publicationsvivo:authorRankauthor rank in publicationAuthorshipDepartmentDivisionvivo:hasResearchArearesearch areasvivo:hrJobTitleHR job titleInformation Resourcevivo:linkedAuthorlinked authorvivo:linkedInformationResourcelinked information resourcevivo:mailingAddressmailing addressvivo:personInPositionpositionsPositionvivo:positionInOrganizationposition in organizationvivo:preferredTitlepreferred titlerdf:predicatepredicaterdf:typetyperdfs:labellabelConceptAgentfoaf:firstNamefirst namefoaf:lastNamelast nameOrganizationPersonCancer BiologyEmergency MedicineMD AndersonRAGHUKALLURIRAGHU KALLURI9841KALLURI, RAGHUProfessorFARHAD R.DANESHFARHAD R. DANESH9888DANESH, FARHAD R.ProfessorSANKARNAVANEETHANSANKAR NAVANEETHAN10348NAVANEETHAN, SANKARProfessor74Professor14Associate Professor6Adjunct Professor1515 Holcombe Blvd.Houston77030TX1.733510.00529088173research areas0.2213090.05607092coauthor of28.2233.1587260similar to1135selected publicationsAuthorship 3728081Authorship 3728094Authorship 3728166Authorship 372822816774905Xu H, Zeng L, Peng H, Chen S, Jones J, Chew TL, Sadeghi MM, Kanwar YS, Danesh FRAmerican journal of physiology. Renal physiologyHMG-CoA reductase inhibitor simvastatin mitigates VEGF-induced "inside-out" signaling to extracellular matrix by preventing RhoA activation. Am J Physiol Renal Physiol. 2006 Nov; 291(5):F995-1004.Am J Physiol Renal Physiol2006-06-13T00:00:002006HMG-CoA reductase inhibitor simvastatin mitigates VEGF-induced "inside-out" signaling to extracellular matrix by preventing RhoA activation.18156300Kanwar YS, Wada J, Sun L, Xie P, Wallner EI, Chen S, Chugh S, Danesh FRExperimental biology and medicine (Maywood, N.J.)Diabetic nephropathy: mechanisms of renal disease progression. Exp Biol Med (Maywood). 2008 Jan; 233(1):4-11.Exp Biol Med (Maywood)2008-01-01T00:00:002008Diabetic nephropathy: mechanisms of renal disease progression.Authorship 842086Authorship 851761Authorship 851880Authorship 854850Authorship 858433Authorship 866356Authorship 867375Authorship 867514Pathophysiology of Diabetic Nephropathy. 151-162.Pathophysiology of Diabetic NephropathyPLoS OneRenal lipotoxicity-associated inflammation and insulin resistance affects actin cytoskeleton organization in podocytes. PLoS One. 10.Renal lipotoxicity-associated inflammation and insulin resistance affects actin cytoskeleton organization in podocytesNature Clinical Practice NephrologyErratum. Nature Clinical Practice Nephrology. 3:233.ErratumClinical and Experimental NephrologyInvolvement of the transforming growth factor-β system in the pathogenesis of diabetic nephropathy. Clinical and Experimental Nephrology. 6:125-129.Involvement of the transforming growth factor-β system in the pathogenesis of diabetic nephropathyPathophysiology and Pathogenesis of Diabetic Nephropathy. 2605-2632.Pathophysiology and Pathogenesis of Diabetic NephropathyPhysiologic Principles in the Clinical Evaluation of Electrolyte, Water, and Acid-Base Disorders. 2477-2511.Physiologic Principles in the Clinical Evaluation of Electrolyte, Water, and Acid-Base DisordersExpert Review of Endocrinology and MetabolismAbnormalities in signaling pathways in diabetic nephropathy. Expert Review of Endocrinology and Metabolism. 5:51-64.Abnormalities in signaling pathways in diabetic nephropathyNephron ExtraEffects of tumor necrosis factor-α on podocyte expression of monocyte chemoattractant protein-1 and in diabetic nephropathy. Nephron Extra. 5:1-18.Effects of tumor necrosis factor-α on podocyte expression of monocyte chemoattractant protein-1 and in diabetic nephropathy15840669Chen S, Lee JS, Iglesias-de la Cruz MC, Wang A, Izquierdo-Lahuerta A, Gandhi NK, Danesh FR, Wolf G, Ziyadeh FNNephrology, dialysis, transplantation : official publication of the European Dialysis and Transplant Association - European Renal AssociationAngiotensin II stimulates alpha3(IV) collagen production in mouse podocytes via TGF-beta and VEGF signalling: implications for diabetic glomerulopathy. Nephrol Dial Transplant. 2005 Jul; 20(7):1320-8.Nephrol Dial Transplant2005-04-19T00:00:002005Angiotensin II stimulates alpha3(IV) collagen production in mouse podocytes via TGF-beta and VEGF signalling: implications for diabetic glomerulopathy.true1ProfessorProfessorD007678Anatomy511570.91569Kidney GlomerulusD016212Chemicals & Drugs49911310.642492Transforming Growth Factor betaD024141Chemicals & Drugs381060.931299Collagen Type IVD050199Anatomy301180.891563PodocytesD003928Disorders681830.822638Diabetic NephropathiesDepartment of MedicineMedicine-Cardiovascular ScienceMedicine-NephrologyBaylor College of MedicineNIKOLAOSFRANGOGIANNISNIKOLAOS FRANGOGIANNIS29.70508570000000-95.401808700000001993FRANGOGIANNIS, NIKOLAOSAdjunct ProfessorAuthorship 9912338Authorship 9912343Authorship 9912366Authorship 9912412Authorship 9912421Authorship 9912442Authorship 9912471Authorship 9912516Authorship 9912521Authorship 9912541Authorship 9912558Authorship 9912652Authorship 9912699Authorship 9916681Authorship 9916697Authorship 9916702Authorship 9916735Authorship 99167511Authorship 9916771Authorship 9916781Authorship 9916797Authorship 991681317804483Wang A, Ziyadeh FN, Lee EY, Pyagay PE, Sung SH, Sheardown SA, Laping NJ, Chen SAmerican journal of physiology. Renal physiologyInterference with TGF-beta signaling by Smad3-knockout in mice limits diabetic glomerulosclerosis without affecting albuminuria. Am J Physiol Renal Physiol. 2007 Nov; 293(5):F1657-65.Am J Physiol Renal Physiol2007-09-05T00:00:002007Interference with TGF-beta signaling by Smad3-knockout in mice limits diabetic glomerulosclerosis without affecting albuminuria.15504975Chen S, Kasama Y, Lee JS, Jim B, Marin M, Ziyadeh FNDiabetesPodocyte-derived vascular endothelial growth factor mediates the stimulation of alpha3(IV) collagen production by transforming growth factor-beta1 in mouse podocytes. Diabetes. 2004 Nov; 53(11):2939-49.Diabetes2004-11-01T00:00:002004Podocyte-derived vascular endothelial growth factor mediates the stimulation of alpha3(IV) collagen production by transforming growth factor-beta1 in mouse podocytes.23704286Chen SJournal of the American Society of Nephrology : JASNRetooling the creatinine clearance equation to estimate kinetic GFR when the plasma creatinine is changing acutely. J Am Soc Nephrol. 2013 May; 24(6):877-88.J Am Soc Nephrol2013-05-23T00:00:002013Retooling the creatinine clearance equation to estimate kinetic GFR when the plasma creatinine is changing acutely.12480514Chen S, Iglesias-de la Cruz MC, Jim B, Hong SW, Isono M, Ziyadeh FNBiochemical and biophysical research communicationsReversibility of established diabetic glomerulopathy by anti-TGF-beta antibodies in db/db mice. Biochem Biophys Res Commun. 2003 Jan 03; 300(1):16-22.Biochem Biophys Res Commun2003-01-03T00:00:002003Reversibility of established diabetic glomerulopathy by anti-TGF-beta antibodies in db/db mice.16804085Wysocki J, Ye M, Soler MJ, Gurley SB, Xiao HD, Bernstein KE, Coffman TM, Chen S, Batlle DDiabetesACE and ACE2 activity in diabetic mice. Diabetes. 2006 Jul; 55(7):2132-9.Diabetes2006-07-01T00:00:002006ACE and ACE2 activity in diabetic mice.15919782Wolf G, Chen S, Ziyadeh FNDiabetesFrom the periphery of the glomerular capillary wall toward the center of disease: podocyte injury comes of age in diabetic nephropathy. Diabetes. 2005 Jun; 54(6):1626-34.Diabetes2005-06-01T00:00:002005From the periphery of the glomerular capillary wall toward the center of disease: podocyte injury comes of age in diabetic nephropathy.11774095Wolf G, Chen S, Han DC, Ziyadeh FNAmerican journal of kidney diseases : the official journal of the National Kidney FoundationLeptin and renal disease. Am J Kidney Dis. 2002 Jan; 39(1):1-11.Am J Kidney Dis2002-01-01T00:00:002002Leptin and renal disease.16164632Cohen MP, Chen S, Ziyadeh FN, Shea E, Hud EA, Lautenslager GT, Shearman CWKidney internationalEvidence linking glycated albumin to altered glomerular nephrin and VEGF expression, proteinuria, and diabetic nephropathy. Kidney Int. 2005 Oct; 68(4):1554-61.Kidney Int2005-10-01T00:00:002005Evidence linking glycated albumin to altered glomerular nephrin and VEGF expression, proteinuria, and diabetic nephropathy.23022193Khoury CC, Khayat MF, Yeo TK, Pyagay PE, Wang A, Asuncion AM, Sharma K, Yu W, Chen SBiochemical and biophysical research communicationsVisualizing the mouse podocyte with multiphoton microscopy. Biochem Biophys Res Commun. 2012 Oct 26; 427(3):525-30.Biochem Biophys Res Commun2012-09-26T00:00:002012Visualizing the mouse podocyte with multiphoton microscopy.21261520Kanwar YS, Sun L, Xie P, Liu FY, Chen SAnnual review of pathologyA glimpse of various pathogenetic mechanisms of diabetic nephropathy. Annu Rev Pathol. 2011; 6:395-423.Annu Rev Pathol2011-01-01T00:00:002011A glimpse of various pathogenetic mechanisms of diabetic nephropathy.12028443Cohen MP, Ziyadeh FN, Hong SW, Shearman CW, Hud E, Lautenslager GT, Iglesias-de la Cruz MC, Chen SKidney internationalInhibiting albumin glycation in vivo ameliorates glomerular overexpression of TGF-beta1. Kidney Int. 2002 Jun; 61(6):2025-32.Kidney Int2002-06-01T00:00:002002Inhibiting albumin glycation in vivo ameliorates glomerular overexpression of TGF-beta1.17251996Chen S, Jalandhara N, Batlle DNature clinical practice. NephrologyEvaluation and management of hyponatremia: an emerging role for vasopressin receptor antagonists. Nat Clin Pract Nephrol. 2007 Feb; 3(2):82-95.Nat Clin Pract Nephrol2007-02-01T00:00:002007Evaluation and management of hyponatremia: an emerging role for vasopressin receptor antagonists.18990304Chen S, Ziyadeh FNCurrent diabetes reportsVascular endothelial growth factor and diabetic nephropathy. Curr Diab Rep. 2008 Dec; 8(6):470-6.Curr Diab Rep2008-12-01T00:00:002008Vascular endothelial growth factor and diabetic nephropathy.25852733Chung CH, Fan J, Lee EY, Kang JS, Lee SJ, Pyagay PE, Khoury CC, Yeo TK, Khayat MF, Wang A, Chen SNephron extraEffects of Tumor Necrosis Factor-a on Podocyte Expression of Monocyte Chemoattractant Protein-1 and in Diabetic Nephropathy. Nephron Extra. 2015 Jan-Apr; 5(1):1-18.Nephron Extra2015-02-04T00:00:002015Effects of Tumor Necrosis Factor-a on Podocyte Expression of Monocyte Chemoattractant Protein-1 and in Diabetic Nephropathy.16697768Cohen MP, Ziyadeh FN, Chen SThe Journal of laboratory and clinical medicineAmadori-modified glycated serum proteins and accelerated atherosclerosis in diabetes: pathogenic and therapeutic implications. J Lab Clin Med. 2006 May; 147(5):211-9.J Lab Clin Med2006-05-01T00:00:002006Amadori-modified glycated serum proteins and accelerated atherosclerosis in diabetes: pathogenic and therapeutic implications.12677169Cohen MP, Shea E, Chen S, Shearman CWThe Journal of laboratory and clinical medicineGlycated albumin increases oxidative stress, activates NF-kappa B and extracellular signal-regulated kinase (ERK), and stimulates ERK-dependent transforming growth factor-beta 1 production in macrophage RAW cells. J Lab Clin Med. 2003 Apr; 141(4):242-9.J Lab Clin Med2003-04-01T00:00:002003Glycated albumin increases oxidative stress, activates NF-kappa B and extracellular signal-regulated kinase (ERK), and stimulates ERK-dependent transforming growth factor-beta 1 production in macrophage RAW cells.19420107Lee EY, Chung CH, Khoury CC, Yeo TK, Pyagay PE, Wang A, Chen SAmerican journal of physiology. Renal physiologyThe monocyte chemoattractant protein-1/CCR2 loop, inducible by TGF-beta, increases podocyte motility and albumin permeability. Am J Physiol Renal Physiol. 2009 Jul; 297(1):F85-94.Am J Physiol Renal Physiol2009-05-06T00:00:002009The monocyte chemoattractant protein-1/CCR2 loop, inducible by TGF-beta, increases podocyte motility and albumin permeability.16988063Sung SH, Ziyadeh FN, Wang A, Pyagay PE, Kanwar YS, Chen SJournal of the American Society of Nephrology : JASNBlockade of vascular endothelial growth factor signaling ameliorates diabetic albuminuria in mice. J Am Soc Nephrol. 2006 Nov; 17(11):3093-104.J Am Soc Nephrol2006-09-20T00:00:002006Blockade of vascular endothelial growth factor signaling ameliorates diabetic albuminuria in mice.17018845Cohen MP, Lautenslager GT, Hud E, Shea E, Wang A, Chen S, Shearman CWAmerican journal of physiology. Renal physiologyInhibiting albumin glycation attenuates dysregulation of VEGFR-1 and collagen IV subchain production and the development of renal insufficiency. Am J Physiol Renal Physiol. 2007 Feb; 292(2):F789-95.Am J Physiol Renal Physiol2006-10-03T00:00:002006Inhibiting albumin glycation attenuates dysregulation of VEGFR-1 and collagen IV subchain production and the development of renal insufficiency.14631561Chen S, Jim B, Ziyadeh FNSeminars in nephrologyDiabetic nephropathy and transforming growth factor-beta: transforming our view of glomerulosclerosis and fibrosis build-up. Semin Nephrol. 2003 Nov; 23(6):532-43.Semin Nephrol2003-11-01T00:00:002003Diabetic nephropathy and transforming growth factor-beta: transforming our view of glomerulosclerosis and fibrosis build-up.26545114Mart?nez-Garc?a C, Izquierdo-Lahuerta A, Vivas Y, Velasco I, Yeo TK, Chen S, Medina-Gomez GPloS oneRenal Lipotoxicity-Associated Inflammation and Insulin Resistance Affects Actin Cytoskeleton Organization in Podocytes. PLoS One. 2015; 10(11):e0142291.PLoS One2015-11-06T00:00:002015Renal Lipotoxicity-Associated Inflammation and Insulin Resistance Affects Actin Cytoskeleton Organization in Podocytes.15086458Chen S, Hoffman BB, Lee JS, Kasama Y, Jim B, Kopp JB, Ziyadeh FNKidney internationalCultured tubule cells from TGF-beta1 null mice exhibit impaired hypertrophy and fibronectin expression in high glucose. Kidney Int. 2004 Apr; 65(4):1191-204.Kidney Int2004-04-01T00:00:002004Cultured tubule cells from TGF-beta1 null mice exhibit impaired hypertrophy and fibronectin expression in high glucose.true1ProfessorProfessorAuthorship 1018074311095645Isono M, Cruz MCI, Chen S, Hong SW, Ziyadeh FNJournal of the American Society of Nephrology : JASNExtracellular signal-regulated kinase mediates stimulation of TGF-beta1 and matrix by high glucose in mesangial cells. J Am Soc Nephrol. 2000 Dec; 11(12):2222-2230.J Am Soc Nephrol2000-12-01T00:00:002000Extracellular signal-regulated kinase mediates stimulation of TGF-beta1 and matrix by high glucose in mesangial cells.true1Adjunct ProfessorAdjunct Professortrue1ProfessorProfessortrue1Associate ProfessorAssociate Professortrue1ProfessorProfessorWOLFGANGWINKELMAYERWOLFGANG WINKELMAYER7258WINKELMAYER, WOLFGANGProfessor12164872Iglesias-de la Cruz MC, Ziyadeh FN, Isono M, Kouahou M, Han DC, Kalluri R, Mundel P, Chen SKidney internationalEffects of high glucose and TGF-beta1 on the expression of collagen IV and vascular endothelial growth factor in mouse podocytes. Kidney Int. 2002 Sep; 62(3):901-13.Kidney Int2002-09-01T00:00:002002Effects of high glucose and TGF-beta1 on the expression of collagen IV and vascular endothelial growth factor in mouse podocytes.