KATRIENVAN ROOSBROECKKATRIEN VAN ROOSBROECK11829VAN ROOSBROECK, KATRIENInstructorprns:coAuthorOfcoauthor ofFaculty Rankprns:fullNamefull nameprns:hasAuthorListauthor listprns:hasFacultyRankhas faculty rankprns:hasNetworkhas networkprns:hasPublicationVenuepublished inprns:informationResourceReferenceinformation resource referenceprns:isPrimaryPositionis primary positionprns:maxWeightmaximum weightprns:medlineTAjournal title abbreviationprns:meshDescriptorUIMeSH DescriptorUIprns:meshSemanticGroupNameMeSH semantic group nameprns:minWeightminimum weightprns:numberOfAuthorsnumber of authorsprns:numberOfConnectionsnumber of connectionsprns:numberOfPublicationsnumber of publicationsprns:personIdPerson IDprns:personInPrimaryPositionperson in primary positionprns:positionInDepartmentposition in departmentprns:positionInDivisionposition in divisionprns:predicateNodepredicate nodeprns:publicationDatepublication dateprns:similarTosimilar toprns:sortOrdersort orderprns:uniquenessWeightuniqueness weightprns:yearyearAcademic ArticleArticleDocumentbibo:pmidPubMed IdentifierAddressvivo:address1address line 1vivo:addressCitycityvivo:addressPostalCodepostal codevivo:addressStatestate or provincevivo:authorInAuthorshipselected publicationsvivo:authorRankauthor rank in publicationAuthorshipDepartmentDivisionvivo:hasResearchArearesearch areasvivo:hrJobTitleHR job titleInformation Resourcevivo:linkedAuthorlinked authorvivo:linkedInformationResourcelinked information resourcevivo:mailingAddressmailing addressvivo:personInPositionpositionsPositionvivo:positionInOrganizationposition in organizationvivo:preferredTitlepreferred titlerdf:predicatepredicaterdf:typetyperdfs:labellabelConceptAgentfoaf:firstNamefirst namefoaf:lastNamelast nameOrganizationPerson25713380Londin E, Loher P, Telonis AG, Quann K, Clark P, Jing Y, Hatzimichael E, Kirino Y, Honda S, Lally M, Ramratnam B, Comstock CE, Knudsen KE, Gomella L, Spaeth GL, Hark L, Katz LJ, Witkiewicz A, Rostami A, Jimenez SA, Hollingsworth MA, Yeh JJ, Shaw CA, McKenzie SE, Bray P, Nelson PT, Zupo S, Van Roosbroeck K, Keating MJ, Calin GA, Yeo C, Jimbo M, Cozzitorto J, Brody JR, Delgrosso K, Mattick JS, Fortina P, Rigoutsos IProceedings of the National Academy of Sciences of the United States of AmericaAnalysis of 13 cell types reveals evidence for the expression of numerous novel primate- and tissue-specific microRNAs. Proc Natl Acad Sci U S A. 2015 Mar 10; 112(10):E1106-15.Proc Natl Acad Sci U S A2015-02-23T00:00:002015Analysis of 13 cell types reveals evidence for the expression of numerous novel primate- and tissue-specific microRNAs.Experimental TherapeuticsHematopathologyLeukemiaMD AndersonWILLIAM GWIERDAWILLIAM G WIERDA8937WIERDA, WILLIAM GProfessorHAGOP MKANTARJIANHAGOP M KANTARJIAN8501KANTARJIAN, HAGOP MProfessorL JEFFREYMEDEIROSL JEFFREY MEDEIROS8762MEDEIROS, L JEFFREYProfessorSRDANVERSTOVSEKSRDAN VERSTOVSEK8781VERSTOVSEK, SRDANProfessorGEORGE ACALINGEORGE A CALIN9408CALIN, GEORGE AProfessorALESSANDRAFERRAJOLIALESSANDRA FERRAJOLI8776FERRAJOLI, ALESSANDRAProfessor23477558Van Roosbroeck K, Pollet J, Calin GAExpert review of molecular diagnosticsmiRNAs and long noncoding RNAs as biomarkers in human diseases. Expert Rev Mol Diagn. 2013 Mar; 13(2):183-204.Expert Rev Mol Diagn2013-03-01T00:00:002013miRNAs and long noncoding RNAs as biomarkers in human diseases.24039846Nouraee N, Van Roosbroeck K, Vasei M, Semnani S, Samaei NM, Naghshvar F, Omidi AA, Calin GA, Mowla SJPloS oneExpression, tissue distribution and function of miR-21 in esophageal squamous cell carcinoma. PLoS One. 2013; 8(9):e73009.PLoS One2013-09-10T00:00:002013Expression, tissue distribution and function of miR-21 in esophageal squamous cell carcinoma.23409773Hudson RS, Yi M, Volfovsky N, Prueitt RL, Esposito D, Volinia S, Liu CG, Schetter AJ, Van Roosbroeck K, Stephens RM, Calin GA, Croce CM, Ambs SMolecular cancerTranscription signatures encoded by ultraconserved genomic regions in human prostate cancer. Mol Cancer. 2013 Feb 14; 12:13.Mol Cancer2013-02-14T00:00:002013Transcription signatures encoded by ultraconserved genomic regions in human prostate cancer.25093380Van Roosbroeck K, Verstovsek S, Calin GALeukemia & lymphomaLong non-coding RNAs in primary myelofibrosis: the dark matter in hematopoietic progenitor cells? Leuk Lymphoma. 2015 Feb; 56(2):281-2.Leuk Lymphoma2015-02-01T00:00:002015Long non-coding RNAs in primary myelofibrosis: the dark matter in hematopoietic progenitor cells?26288818Ferrajoli A, Ivan C, Ciccone M, Shimizu M, Kita Y, Ohtsuka M, D'Abundo L, Qiang J, Lerner S, Nouraee N, Rabe KG, Rassenti LZ, Van Roosbroeck K, Manning JT, Yuan Y, Zhang X, Shanafelt TD, Wierda WG, Sabbioni S, Tarrand JJ, Estrov Z, Radovich M, Liang H, Negrini M, Kipps TJ, Kay NE, Keating M, Calin GAEBioMedicineEpstein-Barr Virus MicroRNAs are Expressed in Patients with Chronic Lymphocytic Leukemia and Correlate with Overall Survival. EBioMedicine. 2015 Jun; 2(6):572-82.EBioMedicine2015-04-29T00:00:002015Epstein-Barr Virus MicroRNAs are Expressed in Patients with Chronic Lymphocytic Leukemia and Correlate with Overall Survival.74Professor10Assistant Professor54Instructor1901 East RoadHouston77054-3005TXCRISTINAIVANCRISTINA IVAN11810IVAN, CRISTINAAssistant Professor1.814220.00532592188research areas5.611430.028935439coauthor of110.0877.4910460similar to1135selected publications26733610Vitale C, Falchi L, Ten Hacken E, Gao H, Shaim H, Van Roosbroeck K, Calin G, O'Brien S, Faderl S, Wang X, Wierda WG, Rezvani K, Reuben JM, Burger JA, Keating MJ, Ferrajoli AClinical cancer research : an official journal of the American Association for Cancer ResearchOfatumumab and Lenalidomide for Patients with Relapsed or Refractory Chronic Lymphocytic Leukemia: Correlation between Responses and Immune Characteristics. Clin Cancer Res. 2016 05 15; 22(10):2359-67.Clin Cancer Res2016-01-05T00:00:002016Ofatumumab and Lenalidomide for Patients with Relapsed or Refractory Chronic Lymphocytic Leukemia: Correlation between Responses and Immune Characteristics.26853146Redis RS, Vela LE, Lu W, Ferreira de Oliveira J, Ivan C, Rodriguez-Aguayo C, Adamoski D, Pasculli B, Taguchi A, Chen Y, Fernandez AF, Valledor L, Van Roosbroeck K, Chang S, Shah M, Kinnebrew G, Han L, Atlasi Y, Cheung LH, Huang GY, Monroig P, Ramirez MS, Catela Ivkovic T, Van L, Ling H, Gaf? R, Kapitanovic S, Lanza G, Bankson JA, Huang P, Lai SY, Bast RC, Rosenblum MG, Radovich M, Ivan M, Bartholomeusz G, Liang H, Fraga MF, Widger WR, Hanash S, Berindan-Neagoe I, Lopez-Berestein G, Ambrosio ALB, Gomes Dias SM, Calin GAMolecular cellAllele-Specific Reprogramming of Cancer Metabolism by the Long Non-coding RNA CCAT2. Mol Cell. 2016 Feb 18; 61(4):520-534.Mol Cell2016-02-04T00:00:002016Allele-Specific Reprogramming of Cancer Metabolism by the Long Non-coding RNA CCAT2.Authorship 3734489Authorship 37359511Authorship 3735962Authorship 3735971Authorship 851830Authorship 852515Authorship 853981Authorship 857528Authorship 861018Authorship 861909Authorship 863398Proceedings of the National Academy of Sciences of the United States of AmericaAnalysis of 13 cell types reveals evidence for the expression of numerous novel primate- And tissue-specific microRNAs. Proceedings of the National Academy of Sciences of the United States of America. 112:E1106-E1115.Analysis of 13 cell types reveals evidence for the expression of numerous novel primate- And tissue-specific microRNAsMolecular CellCorrection to Allele-Specific Reprogramming of Cancer Metabolism by the Long Non-coding RNA CCAT2 [Molecular Cell 61, 520-534, (2016)]. Molecular Cell. 61:640.Correction to Allele-Specific Reprogramming of Cancer Metabolism by the Long Non-coding RNA CCAT2 [Molecular Cell 61, 520-534, (2016)]Clinical Cancer ResearchOfatumumab and lenalidomide for patients with relapsed or refractory chronic lymphocytic leukemia. Clinical Cancer Research. 22:2359-2367.Ofatumumab and lenalidomide for patients with relapsed or refractory chronic lymphocytic leukemiaLeukemia and LymphomaLong non-coding RNAs in primary myelofibrosis. Leukemia and Lymphoma. 56:281-282.Long non-coding RNAs in primary myelofibrosisEBioMedicineEpstein-Barr Virus MicroRNAs are Expressed in Patients with Chronic Lymphocytic Leukemia and Correlate with Overall Survival. EBioMedicine. Epstein-Barr Virus MicroRNAs are Expressed in Patients with Chronic Lymphocytic Leukemia and Correlate with Overall SurvivalBloodWhen kissing (disease) counts. Blood. 127:1947-1948.When kissing (disease) countsGenes Chromosomes and CancerGenomic alterations of the JAK2 and PDL loci occur in a broad spectrum of lymphoid malignancies. Genes Chromosomes and Cancer. 55:428-441.Genomic alterations of the JAK2 and PDL loci occur in a broad spectrum of lymphoid malignanciesAuthorship 8867951Authorship 88714828Authorship 8872636Authorship 88761913D015972Physiology125688690.314255Gene Expression Regulation, NeoplasticAuthorship 8986334Authorship 8991797Authorship 8999331Authorship 9008351Authorship 9018012Authorship 9028522Authorship 9046641Authorship 9091221Authorship 9092571Authorship 91573412Authorship 91794213Authorship 9199301Authorship 9218441Authorship 9229322D053614Chemicals & Drugs1666790.711224Janus Kinase 2Authorship 9306471D035683Chemicals & Drugs75129430.373492MicroRNAsAuthorship 940569118391076Wlodarska I, Dierickx D, Vanhentenrijk V, Van Roosbroeck K, Posp?silov? H, Minnei F, Verhoef G, Thomas J, Vandenberghe P, De Wolf-Peeters CBloodTranslocations targeting CCND2, CCND3, and MYCN do occur in t(11;14)-negative mantle cell lymphomas. Blood. 2008 Jun 15; 111(12):5683-90.Blood2008-04-07T00:00:002008Translocations targeting CCND2, CCND3, and MYCN do occur in t(11;14)-negative mantle cell lymphomas.20207848Van Roosbroeck K, Cools J, Dierickx D, Thomas J, Vandenberghe P, Stul M, Delabie J, De Wolf-Peeters C, Marynen P, Wlodarska IHaematologicaALK-positive large B-cell lymphomas with cryptic SEC31A-ALK and NPM1-ALK fusions. Haematologica. 2010 Mar; 95(3):509-13.Haematologica2010-03-01T00:00:002010ALK-positive large B-cell lymphomas with cryptic SEC31A-ALK and NPM1-ALK fusions.20473312Kleppe M, Lahortiga I, El Chaar T, De Keersmaecker K, Mentens N, Graux C, Van Roosbroeck K, Ferrando AA, Langerak AW, Meijerink JP, Sigaux F, Haferlach T, Wlodarska I, Vandenberghe P, Soulier J, Cools JNature geneticsDeletion of the protein tyrosine phosphatase gene PTPN2 in T-cell acute lymphoblastic leukemia. Nat Genet. 2010 Jun; 42(6):530-5.Nat Genet2010-05-16T00:00:002010Deletion of the protein tyrosine phosphatase gene PTPN2 in T-cell acute lymphoblastic leukemia.21325169Van Roosbroeck K, Cox L, Tousseyn T, Lahortiga I, Gielen O, Cauwelier B, De Paepe P, Verhoef G, Marynen P, Vandenberghe P, De Wolf-Peeters C, Cools J, Wlodarska IBloodJAK2 rearrangements, including the novel SEC31A-JAK2 fusion, are recurrent in classical Hodgkin lymphoma. Blood. 2011 Apr 14; 117(15):4056-64.Blood2011-02-15T00:00:002011JAK2 rearrangements, including the novel SEC31A-JAK2 fusion, are recurrent in classical Hodgkin lymphoma.22230297Put N, Van Roosbroeck K, Vande Broek I, Michaux L, Vandenberghe PLeukemia researchPDS5A, a novel translocation partner of MLL in acute myeloid leukemia. Leuk Res. 2012 Apr; 36(4):e87-9.Leuk Res2012-01-09T00:00:002012PDS5A, a novel translocation partner of MLL in acute myeloid leukemia.22205151Put N, Van Roosbroeck K, Konings P, Meeus P, Brusselmans C, Rack K, Gervais C, Nguyen-Khac F, Chapiro E, Radford-Weiss I, Struski S, Dastugue N, Gachard N, Lefebvre C, Barin C, Eclache V, Fert-Ferrer S, Laibe S, Mozziconacci MJ, Quilichini B, Poirel HA, Wlodarska I, Hagemeijer A, Moreau Y, Vandenberghe P, Michaux L, BCGHo and the GFCHAnnals of hematologyChronic lymphocytic leukemia and prolymphocytic leukemia with MYC translocations: a subgroup with an aggressive disease course. Ann Hematol. 2012 Jun; 91(6):863-73.Ann Hematol2011-12-30T00:00:002011Chronic lymphocytic leukemia and prolymphocytic leukemia with MYC translocations: a subgroup with an aggressive disease course.26850007Van Roosbroeck K, Ferreiro JF, Tousseyn T, van der Krogt JA, Michaux L, Pienkowska-Grela B, Theate I, De Paepe P, Dierickx D, Doyen C, Put N, Cools J, Vandenberghe P, Wlodarska IGenes, chromosomes & cancerGenomic alterations of the JAK2 and PDL loci occur in a broad spectrum of lymphoid malignancies. Genes Chromosomes Cancer. 2016 May; 55(5):428-41.Genes Chromosomes Cancer2016-02-06T00:00:002016Genomic alterations of the JAK2 and PDL loci occur in a broad spectrum of lymphoid malignancies.27040698Van Roosbroeck K, Calin GASeminars in oncologyMicroRNAs in chronic lymphocytic leukemia: miRacle or miRage for prognosis and targeted therapies? Semin Oncol. 2016 Apr; 43(2):209-14.Semin Oncol2016-02-08T00:00:002016MicroRNAs in chronic lymphocytic leukemia: miRacle or miRage for prognosis and targeted therapies?27103742Van Roosbroeck K, Calin GABloodWhen kissing (disease) counts. Blood. 2016 Apr 21; 127(16):1947-8.Blood2016-04-21T00:00:002016When kissing (disease) counts.27903673Van Roosbroeck K, Fanini F, Setoyama T, Ivan C, Rodriguez-Aguayo C, Fuentes-Mattei E, Xiao L, Vannini I, Redis RS, D'Abundo L, Zhang X, Nicoloso MS, Rossi S, Gonzalez-Villasana V, Rupaimoole R, Ferracin M, Morabito F, Neri A, Ruvolo PP, Ruvolo VR, Pecot CV, Amadori D, Abruzzo L, Calin S, Wang X, You MJ, Ferrajoli A, Orlowski R, Plunkett W, Lichtenberg TM, Davuluri RV, Berindan-Neagoe I, Negrini M, Wistuba II, Kantarjian HM, Sood AK, Lopez-Berestein G, Keating MJ, Fabbri M, Calin GAClinical cancer research : an official journal of the American Association for Cancer ResearchCombining Anti-Mir-155 with Chemotherapy for the Treatment of Lung Cancers. Clin Cancer Res. 2017 06 01; 23(11):2891-2904.Clin Cancer Res2016-11-30T00:00:002016Combining Anti-Mir-155 with Chemotherapy for the Treatment of Lung Cancers.28934601Redis RS, Vela LE, Lu W, Ferreira de Oliveira J, Ivan C, Rodriguez-Aguayo C, Adamoski D, Pasculli B, Taguchi A, Chen Y, Fernandez AF, Valledor L, Van Roosbroeck K, Chang S, Shah M, Kinnebrew G, Han L, Atlasi Y, Cheung LH, Huang GY, Monroig P, Ramirez MS, Catela Ivkovic T, Van L, Ling H, Gaf? R, Kapitanovic S, Lanza G, Bankson JA, Huang P, Lai SY, Bast RC, Rosenblum MG, Radovich M, Ivan M, Bartholomeusz G, Liang H, Fraga MF, Widger WR, Hanash S, Berindan-Neagoe I, Lopez-Berestein G, Ambrosio ALB, Gomes Dias SM, Calin GAMolecular cellAllele-Specific Reprogramming of Cancer Metabolism by the Long Non-coding RNA CCAT2. Mol Cell. 2016 Feb 18; 61(4):640.Mol Cell2016-02-18T00:00:002016Allele-Specific Reprogramming of Cancer Metabolism by the Long Non-coding RNA CCAT2.28882220Van Roosbroeck K, Calin GAAdvances in cancer researchCancer Hallmarks and MicroRNAs: The Therapeutic Connection. Adv Cancer Res. 2017; 135:119-149.Adv Cancer Res2017-08-12T00:00:002017Cancer Hallmarks and MicroRNAs: The Therapeutic Connection.29024380Bayraktar R, Van Roosbroeck K, Calin GAMolecular oncologyCell-to-cell communication: microRNAs as hormones. Mol Oncol. 2017 12; 11(12):1673-1686.Mol Oncol2017-10-26T00:00:002017Cell-to-cell communication: microRNAs as hormones.29567676Shah MY, Ferracin M, Pileczki V, Chen B, Redis R, Fabris L, Zhang X, Ivan C, Shimizu M, Rodriguez-Aguayo C, Dragomir M, Van Roosbroeck K, Almeida MI, Ciccone M, Nedelcu D, Cortez MA, Manshouri T, Calin S, Muftuoglu M, Banerjee PP, Badiwi MH, Parker-Thornburg J, Multani A, Welsh JW, Estecio MR, Ling H, Tomuleasa C, Dima D, Yang H, Alvarez H, You MJ, Radovich M, Shpall E, Fabbri M, Rezvani K, Girnita L, Berindan-Neagoe I, Maitra A, Verstovsek S, Fodde R, Bueso-Ramos C, Gagea M, Manero GG, Calin GAGenome researchCancer-associated rs6983267 SNP and its accompanying long noncoding RNA CCAT2 induce myeloid malignancies via unique SNP-specific RNA mutations. Genome Res. 2018 04; 28(4):432-447.Genome Res2018-03-22T00:00:002018Cancer-associated rs6983267 SNP and its accompanying long noncoding RNA CCAT2 induce myeloid malignancies via unique SNP-specific RNA mutations.30409799Van Roosbroeck K, Bayraktar R, Calin S, Bloehdorn J, Dragomir MP, Okubo K, Bertilaccio MTS, Zupo S, You MJ, Gaidano G, Rossi D, Chen SS, Chiorazzi N, Thompson PA, Ferrajoli A, Bertoni F, Stilgenbauer S, Keating MJ, Calin GAHaematologicaThe involvement of microRNA in the pathogenesis of Richter syndrome. Haematologica. 2019 05; 104(5):1004-1015.Haematologica2018-11-08T00:00:002018The involvement of microRNA in the pathogenesis of Richter syndrome.30350212Van Roosbroeck K, Bayraktar R, Calin GAMethods in molecular biology (Clifton, N.J.)Measurement of miRNAs in Chronic Lymphocytic Leukemia Patient Samples by Quantitative Reverse Transcription PCR. Methods Mol Biol. 2019; 1881:267-276.Methods Mol Biol2019-01-01T00:00:002019Measurement of miRNAs in Chronic Lymphocytic Leukemia Patient Samples by Quantitative Reverse Transcription PCR.D015451Disorders29023900.403239Leukemia, Lymphocytic, Chronic, B-CellAuthorship 9439592Authorship 943963229282605Bayraktar R, Van Roosbroeck KCancer metastasis reviewsmiR-155 in cancer drug resistance and as target for miRNA-based therapeutics. Cancer Metastasis Rev. 2018 03; 37(1):33-44.Cancer Metastasis Rev2018-03-01T00:00:002018miR-155 in cancer drug resistance and as target for miRNA-based therapeutics.29285656Calin GA, Van Roosbroeck KCancer metastasis reviewsPreface. Cancer Metastasis Rev. 2018 03; 37(1):3-4.Cancer Metastasis Rev2018-03-01T00:00:002018Preface.D062085Chemicals & Drugs2725980.648717RNA, Long NoncodingAuthorship 961354531746983Debackere K, van der Krogt JA, Tousseyn T, Ferreiro JAF, Van Roosbroeck K, Marcelis L, Graux C, Dierickx D, Ameye G, Vandenberghe P, Michaux L, Cools J, Wlodarska IBloodFER and FES tyrosine kinase fusions in follicular T-cell lymphoma. Blood. 2020 02 20; 135(8):584-588.Blood2020-02-20T00:00:002020FER and FES tyrosine kinase fusions in follicular T-cell lymphoma.Authorship 1031921234680368Esposito CL, Van Roosbroeck K, Santamaria G, Rotoli D, Sandomenico A, Wierda WG, Ferrajoli A, Ruvo M, Calin GA, de Franciscis V, Catuogno SCancersSelection of a Nuclease-Resistant RNA Aptamer Targeting CD19. Cancers (Basel). 2021 Oct 18; 13(20).Cancers (Basel)2021-10-18T00:00:002021Selection of a Nuclease-Resistant RNA Aptamer Targeting CD19.true1ProfessorProfessortrue1ProfessorProfessortrue1InstructorInstructortrue1ProfessorProfessortrue1ProfessorProfessortrue1ProfessorProfessortrue1ProfessorProfessortrue1Assistant ProfessorAssistant Professor