DAVID TWEARDY to Mice
This is a "connection" page, showing publications DAVID TWEARDY has written about Mice.
Connection Strength
0.689
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TTI-101: A competitive inhibitor of STAT3 that spares oxidative phosphorylation and reverses mechanical allodynia in mouse models of neuropathic pain. Biochem Pharmacol. 2021 10; 192:114688.
Score: 0.046
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Protein stabilization improves STAT3 function in autosomal dominant hyper-IgE syndrome. Blood. 2016 12 29; 128(26):3061-3072.
Score: 0.033
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Small-molecule inhibition of STAT3 in radioresistant head and neck squamous cell carcinoma. Oncotarget. 2016 May 03; 7(18):26307-30.
Score: 0.032
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Small-molecule targeting of signal transducer and activator of transcription (STAT) 3 to treat non-small cell lung cancer. Lung Cancer. 2015 Nov; 90(2):182-90.
Score: 0.030
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Modulation of STAT3 folding and function by TRiC/CCT chaperonin. PLoS Biol. 2014 Apr; 12(4):e1001844.
Score: 0.028
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Substance P causes seizures in neurocysticercosis. PLoS Pathog. 2012 Feb; 8(2):e1002489.
Score: 0.024
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IL-6-mediated activation of Stat3a prevents trauma/hemorrhagic shock-induced liver inflammation. PLoS One. 2011; 6(6):e21449.
Score: 0.023
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Stat5: from breast development to cancer prognosis, prediction, and progression. J Clin Oncol. 2011 Jun 20; 29(18):2443-4.
Score: 0.023
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Prevention of trauma/hemorrhagic shock-induced lung apoptosis by IL-6-mediated activation of Stat3. Clin Transl Sci. 2009 Feb; 2(1):41-9.
Score: 0.019
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Substance P receptor antagonism for treatment of cryptosporidiosis in immunosuppressed mice. J Parasitol. 2008 Oct; 94(5):1150-4.
Score: 0.019
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Stat3 isoforms, alpha and beta, demonstrate distinct intracellular dynamics with prolonged nuclear retention of Stat3beta mapping to its unique C-terminal end. J Biol Chem. 2007 Nov 30; 282(48):34958-67.
Score: 0.017
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Conditional overexpression of Stat3alpha in differentiating myeloid cells results in neutrophil expansion and induces a distinct, antiapoptotic and pro-oncogenic gene expression pattern. J Leukoc Biol. 2007 Oct; 82(4):975-85.
Score: 0.017
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Essential role for platelets in organ injury and inflammation in resuscitated hemorrhagic shock. Shock. 2006 Oct; 26(4):386-90.
Score: 0.016
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Interleukin-6 treatment reverses apoptosis and blunts susceptibility to intraperitoneal bacterial challenge following hemorrhagic shock. Crit Care Med. 2006 Mar; 34(3):771-7.
Score: 0.016
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Targeting signal transducer and activator of transcription 3 with G-quartet oligonucleotides: a potential novel therapy for head and neck cancer. Mol Cancer Ther. 2006 Feb; 5(2):279-86.
Score: 0.016
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Enhancing or eliminating signals for cell survival to treat disease. Trans Am Clin Climatol Assoc. 2006; 117:33-51; discussion 51-2.
Score: 0.016
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G-quartet oligonucleotides: a new class of signal transducer and activator of transcription 3 inhibitors that suppresses growth of prostate and breast tumors through induction of apoptosis. Cancer Res. 2004 Sep 15; 64(18):6603-9.
Score: 0.014
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Identification and characterization of signal transducer and activator of transcription 3 recruitment sites within the epidermal growth factor receptor. Cancer Res. 2003 Jul 15; 63(14):3923-30.
Score: 0.013
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Identification and characterization of cis elements in the STAT3 gene regulating STAT3 alpha and STAT3 beta messenger RNA splicing. Blood. 2001 Dec 15; 98(13):3853-6.
Score: 0.012
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Signal Transducer and Activator of Transcription-3 Modulation of Cardiac Pathology in Chronic Chagasic Cardiomyopathy. Front Cell Infect Microbiol. 2021; 11:708325.
Score: 0.011
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Essential role for IL-6 in postresuscitation inflammation in hemorrhagic shock. Am J Physiol Cell Physiol. 2001 Feb; 280(2):C343-51.
Score: 0.011
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Targeting STAT3 anti-apoptosis pathways with organic and hybrid organic-inorganic inhibitors. Org Biomol Chem. 2020 05 06; 18(17):3288-3296.
Score: 0.011
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Stat3 activation induces insulin resistance via a muscle-specific E3 ubiquitin ligase Fbxo40. Am J Physiol Endocrinol Metab. 2020 05 01; 318(5):E625-E635.
Score: 0.010
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Bempegaldesleukin selectively depletes intratumoral Tregs and potentiates T cell-mediated cancer therapy. Nat Commun. 2020 01 31; 11(1):661.
Score: 0.010
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Identification of a novel Stat3 recruitment and activation motif within the granulocyte colony-stimulating factor receptor. Blood. 1999 Jan 01; 93(1):15-24.
Score: 0.010
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Role of STAT3 in skin fibrosis and transforming growth factor beta signalling. Rheumatology (Oxford). 2018 10 01; 57(10):1838-1850.
Score: 0.009
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IL-6 produced by Kupffer cells induces STAT protein activation in hepatocytes early during the course of systemic listerial infections. J Immunol. 1998 Jun 15; 160(12):6056-61.
Score: 0.009
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Essential role of induced nitric oxide in the initiation of the inflammatory response after hemorrhagic shock. J Exp Med. 1998 Mar 16; 187(6):917-28.
Score: 0.009
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Intratumoral CD40 activation and checkpoint blockade induces T cell-mediated eradication of melanoma in the brain. Nat Commun. 2017 11 13; 8(1):1447.
Score: 0.009
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Hemorrhagic shock induces G-CSF expression in bronchial epithelium. Am J Physiol. 1997 11; 273(5):L1058-64.
Score: 0.009
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Multifunctional Effects of a Small-Molecule STAT3 Inhibitor on NASH and Hepatocellular Carcinoma in Mice. Clin Cancer Res. 2017 Sep 15; 23(18):5537-5546.
Score: 0.009
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Diminution of signal transducer and activator of transcription 3 signaling inhibits vascular permeability and anaphylaxis. J Allergy Clin Immunol. 2016 07; 138(1):187-199.
Score: 0.008
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Rhodium(II) Proximity-Labeling Identifies a Novel Target Site on STAT3 for Inhibitors with Potent Anti-Leukemia Activity. Angew Chem Int Ed Engl. 2015 Oct 26; 54(44):13085-9.
Score: 0.008
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Inhibition of Stat3 activation suppresses caspase-3 and the ubiquitin-proteasome system, leading to preservation of muscle mass in cancer cachexia. J Biol Chem. 2015 Apr 24; 290(17):11177-87.
Score: 0.007
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Somatostatin negatively regulates parasite burden and granulomatous responses in cysticercosis. Biomed Res Int. 2014; 2014:247182.
Score: 0.007
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Granulocyte colony-stimulating factor receptor signaling involves the formation of a three-component complex with Lyn and Syk protein-tyrosine kinases. Proc Natl Acad Sci U S A. 1994 May 24; 91(11):4683-7.
Score: 0.007
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Granulocyte colony-stimulating factor receptor mRNA upregulation is an immediate early marker of myeloid differentiation and exhibits dysfunctional regulation in leukemic cells. Blood. 1994 Jan 01; 83(1):119-27.
Score: 0.007
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Mechanism and preclinical prevention of increased breast cancer risk caused by pregnancy. Elife. 2013 Dec 31; 2:e00996.
Score: 0.007
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A dual mechanism of immunosuppression by FK-506. Differential suppression of IL-4 and IL-10 levels in T helper 2 cells. Transplantation. 1993 Oct; 56(4):978-85.
Score: 0.007
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Stat3 activation links a C/EBPd to myostatin pathway to stimulate loss of muscle mass. Cell Metab. 2013 Sep 03; 18(3):368-79.
Score: 0.007
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Nanoparticle delivery of inhibitory signal transducer and activator of transcription 3 G-quartet oligonucleotides blocks tumor growth in HMGA1 transgenic model of T-cell leukemia. Leuk Lymphoma. 2014 May; 55(5):1194-7.
Score: 0.007
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A novel role of microRNA146b in promoting mammary alveolar progenitor cell maintenance. J Cell Sci. 2013 Jun 01; 126(Pt 11):2446-58.
Score: 0.006
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Selective small molecule Stat3 inhibitor reduces breast cancer tumor-initiating cells and improves recurrence free survival in a human-xenograft model. PLoS One. 2012; 7(8):e30207.
Score: 0.006
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Modulation of myeloid proliferation and differentiation by monoclonal antibodies directed against a protein that interacts with the interleukin-3 receptor. Blood. 1992 Jul 15; 80(2):359-66.
Score: 0.006
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FK 506, rapamycin, and cyclosporine: effects on IL-4 and IL-10 mRNA levels in a T-helper 2 cell line. Transplant Proc. 1991 Dec; 23(6):2920-2.
Score: 0.006
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Inhibition of growth of mouse leukemic cell lines in vitro and in vivo by a monoclonal antibody that recognizes an interleukin 3 receptor-associated protein. Cancer Res. 1991 Aug 15; 51(16):4355-9.
Score: 0.006
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Identification of a novel protein capable of interacting with the IL-3 receptor. J Immunol. 1991 Apr 01; 146(7):2295-304.
Score: 0.006
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Production of laminin B2 chain protein and messenger RNA by a murine neutrophil precursor cell line, 32Dc13. Blood. 1990 Oct 01; 76(7):1398-404.
Score: 0.005
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Substance P signaling contributes to granuloma formation in Taenia crassiceps infection, a murine model of cysticercosis. J Biomed Biotechnol. 2010; 2010:597086.
Score: 0.005
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Leukemic transformation by the APL fusion protein PRKAR1A-RAR{alpha} critically depends on recruitment of RXR{alpha}. Blood. 2010 Jan 21; 115(3):643-52.
Score: 0.005
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T40214/PEI complex: a potent therapeutics for prostate cancer that targets STAT3 signaling. Prostate. 2008 Sep 15; 68(13):1430-42.
Score: 0.005
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Tumor-derived growth factors that support proliferation and differentiation of normal and leukemic hemopoietic cells. Ann N Y Acad Sci. 1987; 511:30-8.
Score: 0.004
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Induction of IL-6 within the rodent intestinal muscularis after intestinal surgical stress. Surgery. 2005 Apr; 137(4):436-46.
Score: 0.004
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Functional significance of inflammatory mediators in a murine model of resuscitated hemorrhagic shock. Am J Physiol Heart Circ Physiol. 2005 Mar; 288(3):H1272-7.
Score: 0.004
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Induced nitric oxide promotes intestinal inflammation following hemorrhagic shock. Am J Physiol Gastrointest Liver Physiol. 2004 Feb; 286(2):G225-33.
Score: 0.003
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Inhibition of human squamous cell carcinoma growth in vivo by epidermal growth factor receptor antisense RNA transcribed from the U6 promoter. J Natl Cancer Inst. 1998 Jul 15; 90(14):1080-7.
Score: 0.002
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TCR-gamma genes are rearranged but not transcribed in IL-7R alpha-deficient mice. J Immunol. 1997 Jun 15; 158(12):5744-50.
Score: 0.002
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Augmentation of TNF cytotoxicity by protein kinase C inhibitors: role of arachidonic acid and manganese superoxide dismutase. Cytokine. 1995 Aug; 7(6):517-25.
Score: 0.002
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Granulocyte-macrophage colony-stimulating factor augmentation of T-cell receptor-dependent and T-cell receptor-independent thymocyte proliferation. Blood. 1994 Feb 01; 83(3):713-23.
Score: 0.002
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Lectin-induced apoptosis of tumour cells. Glycobiology. 1993 Oct; 3(5):447-53.
Score: 0.002
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Effect of granulocyte-macrophage colony-stimulating factor on lymphokine-activated killer cell induction. Blood. 1993 May 15; 81(10):2671-8.
Score: 0.002
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Primary listerial infections are exacerbated in mice administered neutralizing antibody to macrophage colony-stimulating factor. J Immunol. 1992 Jul 01; 149(1):188-93.
Score: 0.002
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Evidence that production of interleukin 6 within the rejecting allograft coincides with cytotoxic T lymphocyte development. Transplantation. 1991 Mar; 51(3):656-61.
Score: 0.001
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Cytokine products of T-helper 2 (Th2) cells are present in rejecting sponge matrix allografts. Transplant Proc. 1991 Feb; 23(1 Pt 1):809-10.
Score: 0.001
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Cytokine-dependent granulocytic differentiation. Regulation of proliferative and differentiative responses in a murine progenitor cell line. J Immunol. 1987 Jun 01; 138(11):3829-35.
Score: 0.001
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Gene for alpha-chain of human T-cell receptor: location on chromosome 14 region involved in T-cell neoplasms. Science. 1985 Mar 01; 227(4690):1044-7.
Score: 0.001