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TAKASHI SHINGU

TitleInstructor
InstitutionMD Anderson
DepartmentCancer Biology
Address1881 East Road
Houston TX 77054-3005
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    Publications listed below are automatically derived from MEDLINE/PubMed and other sources, which might result in incorrect or missing publications. Faculty can login to make corrections and additions.
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    PMC Citations indicate the number of times the publication was cited by articles in PubMed Central, and the Altmetric score represents citations in news articles and social media. (Note that publications are often cited in additional ways that are not shown here.) Fields are based on how the National Library of Medicine (NLM) classifies the publication's journal and might not represent the specific topic of the publication. Translation tags are based on the publication type and the MeSH terms NLM assigns to the publication. Some publications (especially newer ones and publications not in PubMed) might not yet be assigned Field or Translation tags.) Click a Field or Translation tag to filter the publications.
    1. Chen CH, Chin RL, Hartley GP, Lea ST, Engel BJ, Hsieh CE, Prasad R, Roszik J, Shingu T, Lizee GA, Heimberger AB, Millward SW, Hu J, Hong DS, Curran MA. Novel murine glioblastoma models that reflect the immunotherapy resistance profile of a human disease. Neuro Oncol. 2023 08 03; 25(8):1415-1427. PMID: 36705543; PMCID: PMC10398813.
      Citations:    Fields:    Translation:HumansAnimalsCells
    2. Aksoy Yasar FB, Shingu T, Zamler DB, Zaman MF, Chien DL, Zhang Q, Ren J, Hu J. Quaking but not parkin is the major tumor suppressor in 6q deleted region in glioblastoma. Front Cell Dev Biol. 2022; 10:931387. PMID: 36051438; PMCID: PMC9424994.
      Citations:    
    3. Zamler DB, Shingu T, Kahn LM, Huntoon K, Kassab C, Ott M, Tomczak K, Liu J, Li Y, Lai I, Zorilla-Veloz R, Yee C, Rai K, Kim BY, Watowich SS, Heimberger AB, Draetta GF, Hu J. Immune landscape of a genetically engineered murine model of glioma compared with human glioma. JCI Insight. 2022 06 22; 7(12). PMID: 35653194; PMCID: PMC9309065.
      Citations:    Fields:    Translation:HumansAnimalsCells
    4. Shin S, Zhou H, He C, Wei Y, Wang Y, Shingu T, Zeng A, Wang S, Zhou X, Li H, Zhang Q, Mo Q, Long J, Lan F, Chen Y, Hu J. Qki activates Srebp2-mediated cholesterol biosynthesis for maintenance of eye lens transparency. Nat Commun. 2021 05 21; 12(1):3005. PMID: 34021134; PMCID: PMC8139980.
      Citations: 4     Fields:    Translation:HumansAnimalsCells
    5. Zhou X, Shin S, He C, Zhang Q, Rasband MN, Ren J, Dai C, Shingu T, Yuan L, Wang Y, Chen Y, Lan F, Hu J, Zorrilla-Veloz RI. Qki regulates myelinogenesis through Srebp2-dependent cholesterol biosynthesis. Elife. 2021 05 04; 10. PMID: 33942715; PMCID: PMC8139834.
      Citations: 2     Fields:    Translation:AnimalsCells
    6. Inoue A, Robinson FS, Minelli R, Tomihara H, Rizi BS, Rose JL, Kodama T, Srinivasan S, Harris AL, Zuniga AM, Mullinax RA, Ma X, Seth S, Daniele JR, Peoples MD, Loponte S, Akdemir KC, Khor TO, Feng N, Roszik J, Sobieski MM, Brunell D, Stephan C, Giuliani V, Deem AK, Shingu T, Deribe YL, Menter DG, Heffernan TP, Viale A, Bristow CA, Kopetz S, Draetta GF, Genovese G, Carugo A. Sequential Administration of XPO1 and ATR Inhibitors Enhances Therapeutic Response in TP53-mutated Colorectal Cancer. Gastroenterology. 2021 07; 161(1):196-210. PMID: 33745946; PMCID: PMC8238881.
      Citations: 3     Fields:    Translation:HumansAnimalsCells
    7. Ren J, Dai C, Zhou X, Barnes JA, Chen X, Wang Y, Yuan L, Shingu T, Heimberger AB, Chen Y, Hu J. Qki is an essential regulator of microglial phagocytosis in demyelination. J Exp Med. 2021 01 04; 218(1). PMID: 33045062; PMCID: PMC7543092.
      Citations: 3     Fields:    Translation:HumansAnimalsCells
    8. Zhou X, He C, Ren J, Dai C, Stevens SR, Wang Q, Zamler D, Shingu T, Yuan L, Chandregowda CR, Wang Y, Ravikumar V, Rao AU, Zhou F, Zheng H, Rasband MN, Chen Y, Lan F, Heimberger AB, Segal BM, Hu J. Mature myelin maintenance requires Qki to coactivate PPAR?-RXRa-mediated lipid metabolism. J Clin Invest. 2020 05 01; 130(5):2220-2236. PMID: 32202512; PMCID: PMC7191000.
      Citations: 17     Fields:    Translation:HumansAnimalsCells
    9. Shingu T, Ho AL, Yuan L, Zhou X, Dai C, Zheng S, Wang Q, Zhong Y, Chang Q, Horner JW, Liebelt BD, Yao Y, Hu B, Chen Y, Fuller GN, Verhaak RG, Heimberger AB, Hu J. Qki deficiency maintains stemness of glioma stem cells in suboptimal environment by downregulating endolysosomal degradation. Nat Genet. 2017 01; 49(1):75-86. PMID: 27841882; PMCID: PMC5453714.
      Citations: 39     Fields:    Translation:AnimalsCells
    10. Shingu T, Holmes L, Henry V, Wang Q, Latha K, Gururaj AE, Gibson LA, Doucette T, Lang FF, Rao G, Yuan L, Sulman EP, Farrell NP, Priebe W, Hess KR, Wang YA, Hu J, B?gler O. Suppression of RAF/MEK or PI3K synergizes cytotoxicity of receptor tyrosine kinase inhibitors in glioma tumor-initiating cells. J Transl Med. 2016 Feb 09; 14:46. PMID: 26861698; PMCID: PMC4746796.
      Citations: 16     Fields:    Translation:HumansAnimalsCells
    11. Liebelt BD, Shingu T, Zhou X, Ren J, Shin SA, Hu J. Glioma Stem Cells: Signaling, Microenvironment, and Therapy. Stem Cells Int. 2016; 2016:7849890. PMID: 26880988; PMCID: PMC4736567.
      Citations: 82     
    12. Shingu T, Jaskelioff M, Yuan L, Ding Z, Protopopov A, Kost-Alimova M, Hu J. Utilizing murine inducible telomerase alleles in the studies of tissue degeneration/regeneration and cancer. J Vis Exp. 2015 Apr 13; (98). PMID: 25938254; PMCID: PMC4526143.
      Citations: 2     Fields:    Translation:AnimalsCells
    13. Zhou Y, Zhou Y, Shingu T, Feng L, Chen Z, Ogasawara M, Keating MJ, Kondo S, Huang P. Metabolic alterations in highly tumorigenic glioblastoma cells: preference for hypoxia and high dependency on glycolysis. J Biol Chem. 2011 Sep 16; 286(37):32843-53. PMID: 21795717; PMCID: PMC3173179.
      Citations: 120     Fields:    Translation:HumansAnimalsCells
    14. Gwak HS, Shingu T, Chumbalkar V, Hwang YH, DeJournett R, Latha K, Koul D, Alfred Yung WK, Powis G, Farrell NP, B?gler O. Combined action of the dinuclear platinum compound BBR3610 with the PI3-K inhibitor PX-866 in glioblastoma. Int J Cancer. 2011 Feb 15; 128(4):787-96. PMID: 20473884; PMCID: PMC2990813.
      Citations: 10     Fields:    Translation:HumansAnimalsCells
    15. Shingu T, Chumbalkar VC, Gwak HS, Fujiwara K, Kondo S, Farrell NP, Bogler O. The polynuclear platinum BBR3610 induces G2/M arrest and autophagy early and apoptosis late in glioma cells. Neuro Oncol. 2010 Dec; 12(12):1269-77. PMID: 20713409; PMCID: PMC3018945.
      Citations: 11     Fields:    Translation:HumansAnimalsCells
    16. Shingu T, Fujiwara K, Akiyama Y, Moritake K, Shinojima N, Tamada Y, Yokoyama T, Kondo S, B?gler O. Stage-specific effect of inhibition of autophagy on chemotherapy-induced cytotoxicity. Autophagy. 2009 May; 5(4):537-9. PMID: 19270491.
      Citations: 16     Fields:    Translation:Humans
    17. Shingu T, Fujiwara K, Akiyama Y, Moritake K, Shinojima N, Tamada Y, Yokoyama T, Kondo S, B?gler O. Inhibition of autophagy at a late stage enhances imatinib-induced cytotoxicity in human malignant glioma cells. Int J Cancer. 2009 Mar 01; 124(5):1060-71. PMID: 19048625.
      Citations: 68     Fields:    Translation:HumansCells
    18. Aoki H, Kondo Y, Aldape K, Yamamoto A, Iwado E, Yokoyama T, Hollingsworth EF, Kobayashi R, Hess K, Shinojima N, Shingu T, Tamada Y, Zhang L, Conrad C, Bogler O, Mills G, Sawaya R, Kondo S. Monitoring autophagy in glioblastoma with antibody against isoform B of human microtubule-associated protein 1 light chain 3. Autophagy. 2008 May; 4(4):467-75. PMID: 18259115.
      Citations: 50     Fields:    Translation:HumansAnimalsCells
    19. Shingu T, Akiyama Y, Daisu M, Maruyama N, Matsumoto Y, Miyazaki T, Nagai H, Yamamoto Y, Yamasaki T, Yoshida M, Maruyama R, Moritake K. Symptomatic hemorrhage associated with recurrent pilocytic astrocytoma with granulation tissue--case report. Neurol Med Chir (Tokyo). 2007 May; 47(5):222-8. PMID: 17527050.
      Citations: 3     Fields:    Translation:Humans
    20. Shingu T, Kagawa T, Kimura Y, Takada D, Moritake K, Hoshii Y. Supratentorial primitive neuroectodermal tumor in an aged patient--case report--. Neurol Med Chir (Tokyo). 2005 Oct; 45(10):530-5. PMID: 16247240.
      Citations: 9     Fields:    Translation:Humans
    21. Shingu T, Yamada K, Hara N, Moritake K, Osago H, Terashima M, Uemura T, Yamasaki T, Tsuchiya M. Synergistic augmentation of antimicrotubule agent-induced cytotoxicity by a phosphoinositide 3-kinase inhibitor in human malignant glioma cells. Cancer Res. 2003 Jul 15; 63(14):4044-7. PMID: 12874004.
      Citations: 20     Fields:    Translation:HumansCells
    22. Yamasaki T, Moritake K, Nagai H, Uemura T, Shingu T, Matsumoto Y. A new, miniature ultrasonic surgical aspirator with a handpiece designed for transsphenoidal surgery. Technical note. J Neurosurg. 2003 Jul; 99(1):177-9. PMID: 12854763.
      Citations: 1     Fields:    Translation:Humans
    23. Shingu T, Yamada K, Hara N, Moritake K, Osago H, Terashima M, Uemura T, Yamasaki T, Tsuchiya M. Growth inhibition of human malignant glioma cells induced by the PI3-K-specific inhibitor. J Neurosurg. 2003 Jan; 98(1):154-61. PMID: 12546364.
      Citations: 11     Fields:    Translation:HumansCells
    24. Uemura T, Moritake K, Akiyama Y, Kimura Y, Shingu T, Yamasaki T. Experimental validation of deuterium oxide-mediated antitumoral activity as it relates to apoptosis in murine malignant astrocytoma cells. J Neurosurg. 2002 May; 96(5):900-8. PMID: 12005398.
      Citations: 7     Fields:    Translation:HumansAnimalsCells
    25. Yasunobu Y, Hayashi K, Shingu T, Nomura K, Ohkura Y, Tanaka K, Kuga Y, Nomura S, Ohtani H, Nishimura T, Matsuura H, Kajiyama G. Reduction of plasma cholesterol levels and induction of hepatic LDL receptor by cerivastatin sodium (CAS 143201-11-0, BAY w 6228), a new inhibitor of 3-hydroxy-3-methylglutaryl coenzyme A reductase, in dogs. Cardiovasc Drugs Ther. 1997 Sep; 11(4):567-74. PMID: 9358961.
      Citations: 2     Fields:    Translation:HumansAnimalsCells
    26. Kondo S, Mishiro N, Umeki K, Kotani T, Setoguchi M, Shingu T, Ohtaki S. Human T-lymphotropic virus type I (HTLV-I) DNA in an HTLV-I-endemic area (Miyazaki, Japan) Transfusion. 1994 May; 34(5):449-50. PMID: 8191572.
      Citations:    Fields:    Translation:Humans
    27. Matsumoto S, Yamamoto T, Ban S, Motozaki T, Sato S, Shingu T, Yoshida S, Tsuiki H. Spontaneous subperiosteal hematoma of the orbit--case report. Neurol Med Chir (Tokyo). 1994 Jan; 34(1):27-9. PMID: 7514750.
      Citations: 1     Fields:    Translation:Humans
    28. Wu TS, Lin YM, Haruna M, Pan DJ, Shingu T, Chen YP, Hsu HY, Nakano T, Lee KH. Antitumor agents, 119. Kansuiphorins A and B, two novel antileukemic diterpene esters from Euphorbia kansui. J Nat Prod. 1991 May-Jun; 54(3):823-9. PMID: 1955882.
      Citations: 17     Fields:    Translation:HumansAnimalsCells
    29. Gi H, Nagao S, Yoshizumi H, Nishioka T, Uno J, Shingu T, Fujita Y. Meningioma with hypergammaglobulinemia. Case report. J Neurosurg. 1990 Oct; 73(4):628-9. PMID: 2398394.
      Citations: 8     Fields:    Translation:HumansCells
    30. Yamada K, Matsunaga M, Fujita Y, Araki O, Shingu T, Gi H. [Brain abscess: successful treatment of 4 cases including one with ventricular perforation]. No Shinkei Geka. 1983 Sep; 11(9):967-73. PMID: 6664453.
      Citations:    Fields:    Translation:Humans
    31. Fujita Y, Shingu T, Yamada K, Araki O, Matsunaga M, Mori K, Kawano T. [Noxious free radicals derived from oxyhemoglobin as a cause of prolonged vasospasm]. Neurol Med Chir (Tokyo). 1980 Feb; 20(2):137-44. PMID: 6153765.
      Citations:    Fields:    Translation:Humans
    32. Shingu T, Fujita Y, Araki O, Matsumoto Y, Matsunaga M. [99m Tc scan dynamics in cerebral infarcted area--as an indicator of vascular reconstruction (author's transl)]. Neurol Med Chir (Tokyo). 1979 Nov; 19(11):1063-70. PMID: 93246.
      Citations:    Fields:    Translation:Humans
    33. Glioma Stem Cells. Stem Cells International. 2016.
    34. Pharmacokinetic analysis of etoposide concentration in intracranial tumor cavity after intravenous injection in 5 cases of glioblastoma and metastatic brain tumor. Journal of Japan Society for Cancer Therapy. 31:420-426.
    35. Suppression of RAF/MEK or PI3K synergizes cytotoxicity of receptor tyrosine kinase inhibitors in glioma tumor-initiating cells. Journal of Translational Medicine.
    36. Qki deficiency maintains stemness of glioma stem cells in suboptimal environment by downregulating endolysosomal degradation. Nature Genetics. 49:75-86.
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