RAJATBHATTACHARYARAJAT BHATTACHARYA9706BHATTACHARYA, RAJATInstructorprns:coAuthorOfcoauthor ofFaculty Rankprns:fullNamefull nameprns:hasAuthorListauthor listprns:hasFacultyRankhas faculty rankprns:hasNetworkhas networkprns:hasPublicationVenuepublished inprns:informationResourceReferenceinformation resource referenceprns:isPrimaryPositionis primary positionprns:maxWeightmaximum weightprns:medlineTAjournal title abbreviationprns:meshDescriptorUIMeSH DescriptorUIprns:meshSemanticGroupNameMeSH semantic group nameprns:minWeightminimum weightprns:numberOfAuthorsnumber of authorsprns:numberOfConnectionsnumber of connectionsprns:numberOfPublicationsnumber of publicationsprns:personIdPerson IDprns:personInPrimaryPositionperson in primary positionprns:positionInDepartmentposition in departmentprns:positionInDivisionposition in divisionprns:predicateNodepredicate nodeprns:publicationDatepublication dateprns:similarTosimilar toprns:sortOrdersort orderprns:uniquenessWeightuniqueness weightprns:yearyearAcademic ArticleArticleDocumentbibo:pmidPubMed IdentifierAddressvivo:address1address line 1vivo:addressCitycityvivo:addressPostalCodepostal codevivo:addressStatestate or provincevivo:authorInAuthorshipselected publicationsvivo:authorRankauthor rank in publicationAuthorshipDepartmentDivisionvivo:hasResearchArearesearch areasvivo:hrJobTitleHR job titleInformation Resourcevivo:linkedAuthorlinked authorvivo:linkedInformationResourcelinked information resourcevivo:mailingAddressmailing addressvivo:personInPositionpositionsPositionvivo:positionInOrganizationposition in organizationvivo:preferredTitlepreferred titlerdf:predicatepredicaterdf:typetyperdfs:labellabelConceptAgentfoaf:firstNamefirst namefoaf:lastNamelast nameOrganizationPerson1515 Holcombe BlvdHouston77030-4009TXAuthorship 1662043Authorship 1811952Authorship 1894422Authorship 19518159110994Das AK, Dasgupta B, Bhattacharya R, Basu JThe Journal of biological chemistryPurification and biochemical characterization of a protein-palmitoyl acyltransferase from human erythrocytes. J Biol Chem. 1997 Apr 25; 272(17):11021-5.J Biol Chem1997-04-25T00:00:001997Purification and biochemical characterization of a protein-palmitoyl acyltransferase from human erythrocytes.18843200Ganguly A, Bhattacharya R, Cabral FCell cycle (Georgetown, Tex.)Cell cycle dependent degradation of MCAK: evidence against a role in anaphase chromosome movement. Cell Cycle. 2008 Oct; 7(20):3187-93.Cell Cycle2008-10-18T00:00:002008Cell cycle dependent degradation of MCAK: evidence against a role in anaphase chromosome movement.22422706Ganguly A, Bhattacharya R, Cabral FCytoskeleton (Hoboken, N.J.)Control of MCAK degradation and removal from centromeres. Cytoskeleton (Hoboken). 2012 May; 69(5):303-11.Cytoskeleton (Hoboken)2012-04-03T00:00:002012Control of MCAK degradation and removal from centromeres.Epigenetics & Molecular CarcinogenesisGI Medical OncologyGynecological Oncology & Reproductive MedicineLeukemiaMelanoma Medical OncologySurgical OncologyMD AndersonXIANGCANGYEXIANGCANG YE8648YE, XIANGCANGAssistant ProfessorHAGOP MKANTARJIANHAGOP M KANTARJIAN8501KANTARJIAN, HAGOP MProfessorJEAN NICOLASVAUTHEYJEAN NICOLAS VAUTHEY8766VAUTHEY, JEAN NICOLASProfessorLEE MELLISLEE M ELLIS8478ELLIS, LEE MProfessorELIZABETH AGRIMMELIZABETH A GRIMM8484GRIMM, ELIZABETH AProfessorCHANDRANICHATTOPADHYAYCHANDRANI CHATTOPADHYAY8925CHATTOPADHYAY, CHANDRANIAssistant ProfessorCATHYENGCATHY ENG9041ENG, CATHYProfessorANIL KSOODANIL K SOOD9048SOOD, ANIL KProfessor1.723470.00464212251research areas3.905180.026186528coauthor of40.2445.9399460similar to1137selected publicationsAuthorship 2256191Authorship 2276782Authorship 2278911Authorship 234495518553364Bhattacharya R, Frankfurter A, Cabral FCell motility and the cytoskeletonA minor beta-tubulin essential for mammalian cell proliferation. Cell Motil Cytoskeleton. 2008 Sep; 65(9):708-20.Cell Motil Cytoskeleton2008-09-01T00:00:002008A minor beta-tubulin essential for mammalian cell proliferation.19282281Bhattacharya R, Cabral FThe Journal of biological chemistryMolecular basis for class V beta-tubulin effects on microtubule assembly and paclitaxel resistance. J Biol Chem. 2009 May 08; 284(19):13023-32.J Biol Chem2009-03-12T00:00:002009Molecular basis for class V beta-tubulin effects on microtubule assembly and paclitaxel resistance.20103599Yin S, Bhattacharya R, Cabral FMolecular cancer therapeuticsHuman mutations that confer paclitaxel resistance. Mol Cancer Ther. 2010 Feb; 9(2):327-35.Mol Cancer Ther2010-01-26T00:00:002010Human mutations that confer paclitaxel resistance.24132143Zhou Y, Bollu LR, Tozzi F, Ye X, Bhattacharya R, Gao G, Dupre E, Xia L, Lu J, Fan F, Bellister S, Ellis LM, Weihua ZMolecular cancer therapeuticsATP citrate lyase mediates resistance of colorectal cancer cells to SN38. Mol Cancer Ther. 2013 Dec; 12(12):2782-91.Mol Cancer Ther2013-10-16T00:00:002013ATP citrate lyase mediates resistance of colorectal cancer cells to SN38.Authorship 2401752Authorship 2472431Authorship 25408237925374Das AK, Bhattacharya R, Kundu M, Chakrabarti P, Basu JEuropean journal of biochemistryHuman erythrocyte membrane protein 4.2 is palmitoylated. Eur J Biochem. 1994 Sep 01; 224(2):575-80.Eur J Biochem1994-09-01T00:00:001994Human erythrocyte membrane protein 4.2 is palmitoylated.15121885Bhattacharya R, Cabral FMolecular biology of the cellA ubiquitous beta-tubulin disrupts microtubule assembly and inhibits cell proliferation. Mol Biol Cell. 2004 Jul; 15(7):3123-31.Mol Biol Cell2004-04-30T00:00:002004A ubiquitous beta-tubulin disrupts microtubule assembly and inhibits cell proliferation.19625384Yang H, Cabral F, Bhattacharya RProtein engineering, design & selection : PEDSTubulin isotype specificity and identification of the epitope for antibody Tub 2.1. Protein Eng Des Sel. 2009 Oct; 22(10):625-9.Protein Eng Des Sel2009-07-22T00:00:002009Tubulin isotype specificity and identification of the epitope for antibody Tub 2.1.Authorship 2670513Authorship 2693431Authorship 270495417394764Datta HJ, Mandal P, Bhattacharya R, Das N, Sau S, Mandal NCJournal of biochemistry and molecular biologyThe G23 and G25 genes of temperate mycobacteriophage L1 are essential for the transcription of its late genes. J Biochem Mol Biol. 2007 Mar 31; 40(2):156-62.J Biochem Mol Biol2007-03-31T00:00:002007The G23 and G25 genes of temperate mycobacteriophage L1 are essential for the transcription of its late genes.21289088Bhattacharya R, Yang H, Cabral FMolecular biology of the cellClass V ?-tubulin alters dynamic instability and stimulates microtubule detachment from centrosomes. Mol Biol Cell. 2011 Apr; 22(7):1025-34.Mol Biol Cell2011-02-02T00:00:002011Class V ?-tubulin alters dynamic instability and stimulates microtubule detachment from centrosomes.21903575Ganguly A, Yang H, Pedroza M, Bhattacharya R, Cabral FThe Journal of biological chemistryMitotic centromere-associated kinesin (MCAK) mediates paclitaxel resistance. J Biol Chem. 2011 Oct 21; 286(42):36378-84.J Biol Chem2011-09-07T00:00:002011Mitotic centromere-associated kinesin (MCAK) mediates paclitaxel resistance.Authorship 277161112450216Bhattacharya R, Perumal K, Sinha K, Maraia R, Reddy RGene expressionMethylphosphate cap structure in small RNAs reduces the affinity of RNAs to La protein. Gene Expr. 2002; 10(5-6):243-53.Gene Expr2002-01-01T00:00:002002Methylphosphate cap structure in small RNAs reduces the affinity of RNAs to La protein.Authorship 2921747Authorship 305226325281617Pecot CV, Wu SY, Bellister S, Filant J, Rupaimoole R, Hisamatsu T, Bhattacharya R, Maharaj A, Azam S, Rodriguez-Aguayo C, Nagaraja AS, Morelli MP, Gharpure KM, Waugh TA, Gonzalez-Villasana V, Zand B, Dalton HJ, Kopetz S, Lopez-Berestein G, Ellis LM, Sood AKMolecular cancer therapeuticsTherapeutic silencing of KRAS using systemically delivered siRNAs. Mol Cancer Ther. 2014 Dec; 13(12):2876-85.Mol Cancer Ther2014-10-03T00:00:002014Therapeutic silencing of KRAS using systemically delivered siRNAs.26041938Ye X, Fan F, Bhattacharya R, Bellister S, Boulbes DR, Wang R, Xia L, Ivan C, Zheng X, Calin GA, Wang J, Lu X, Ellis LMMolecular cancer research : MCRVEGFR-1 Pseudogene Expression and Regulatory Function in Human Colorectal Cancer Cells. Mol Cancer Res. 2015 Sep; 13(9):1274-82.Mol Cancer Res2015-06-03T00:00:002015VEGFR-1 Pseudogene Expression and Regulatory Function in Human Colorectal Cancer Cells.74Professor10Assistant Professor54Instructor14Associate ProfessorMANU MSEBASTIANMANU M SEBASTIAN12759SEBASTIAN, MANU MAssociate ProfessorAuthorship 847719Authorship 859866Authorship 865718Molecular Cancer ResearchVEGFR-1 pseudogene expression and regulatory function in human colorectal cancer cells. Molecular Cancer Research. 13:1274-1282.VEGFR-1 pseudogene expression and regulatory function in human colorectal cancer cellsCancer ResearchIntracrine VEGF signaling mediates the activity of prosurvival pathways in human colorectal cancer cells. Cancer Research. 76:3014-3024.Intracrine VEGF signaling mediates the activity of prosurvival pathways in human colorectal cancer cellsStem cells translational medicineA disintegrin and metalloproteinase domain 17 regulates colorectal cancer stem cells and chemosensitivity via Notch1 signaling. Stem cells translational medicine. 5:331-338.A disintegrin and metalloproteinase domain 17 regulates colorectal cancer stem cells and chemosensitivity via Notch1 signaling28483840Ye X, Wang R, Bhattacharya R, Boulbes DR, Fan F, Xia L, Adoni H, Ajami NJ, Wong MC, Smith DP, Petrosino JF, Venable S, Qiao W, Baladandayuthapani V, Maru D, Ellis LMCancer prevention research (Philadelphia, Pa.)Fusobacterium Nucleatum Subspecies Animalis Influences Proinflammatory Cytokine Expression and Monocyte Activation in Human Colorectal Tumors. Cancer Prev Res (Phila). 2017 Jul; 10(7):398-409.Cancer Prev Res (Phila)2017-05-08T00:00:002017Fusobacterium Nucleatum Subspecies Animalis Influences Proinflammatory Cytokine Expression and Monocyte Activation in Human Colorectal Tumors.Authorship 8880453D014404Chemicals & Drugs1141690.942957TubulinD020929Chemicals & Drugs2303710.823684Mitogen-Activated Protein Kinase KinasesD015179Disorders68335630.327321Colorectal NeoplasmsD016283Chemicals & Drugs44413280.601144Proto-Oncogene Proteins p21(ras)D008870Anatomy1652700.88132MicrotubulesAuthorship 9065983Authorship 9110021Authorship 9148241Authorship 9197226Authorship 9201208Authorship 9227182Authorship 9267441Authorship 930721226744411Wang R, Ye X, Bhattacharya R, Boulbes DR, Fan F, Xia L, Ellis LMStem cells translational medicineA Disintegrin and Metalloproteinase Domain 17 Regulates Colorectal Cancer Stem Cells and Chemosensitivity Via Notch1 Signaling. Stem Cells Transl Med. 2016 Mar; 5(3):331-8.Stem Cells Transl Med2016-01-07T00:00:002016A Disintegrin and Metalloproteinase Domain 17 Regulates Colorectal Cancer Stem Cells and Chemosensitivity Via Notch1 Signaling.26988990Bhattacharya R, Ye XC, Wang R, Ling X, McManus M, Fan F, Boulbes D, Ellis LMCancer researchIntracrine VEGF Signaling Mediates the Activity of Prosurvival Pathways in Human Colorectal Cancer Cells. Cancer Res. 2016 05 15; 76(10):3014-24.Cancer Res2016-03-17T00:00:002016Intracrine VEGF Signaling Mediates the Activity of Prosurvival Pathways in Human Colorectal Cancer Cells.28453235Wang R, Bhattacharya R, Ye X, Fan F, Boulbes DR, Xia L, Ellis LMMolecular oncologyEndothelial cells activate the cancer stem cell-associated NANOGP8 pathway in colorectal cancer cells in a paracrine fashion. Mol Oncol. 2017 08; 11(8):1023-1034.Mol Oncol2017-06-06T00:00:002017Endothelial cells activate the cancer stem cell-associated NANOGP8 pathway in colorectal cancer cells in a paracrine fashion.28742793Bhattacharya R, Fan F, Wang R, Ye X, Xia L, Boulbes D, Ellis LMBritish journal of cancerIntracrine VEGF signalling mediates colorectal cancer cell migration and invasion. Br J Cancer. 2017 Sep 05; 117(6):848-855.Br J Cancer2017-07-25T00:00:002017Intracrine VEGF signalling mediates colorectal cancer cell migration and invasion.29226979Bhattacharya R, Ellis LMBioEssays : news and reviews in molecular, cellular and developmental biologyIt Is Time to Re-Evaluate the Peer Review Process for Preclinical Research. Bioessays. 2018 Jan; 40(1).Bioessays2017-12-11T00:00:002017It Is Time to Re-Evaluate the Peer Review Process for Preclinical Research.29293549Fan F, Wang R, Boulbes DR, Zhang H, Watowich SS, Xia L, Ye X, Bhattacharya R, Ellis LMPloS oneMacrophage conditioned medium promotes colorectal cancer stem cell phenotype via the hedgehog signaling pathway. PLoS One. 2018; 13(1):e0190070.PLoS One2018-01-02T00:00:002018Macrophage conditioned medium promotes colorectal cancer stem cell phenotype via the hedgehog signaling pathway.29643062Boulbes DR, Costello T, Baggerly K, Fan F, Wang R, Bhattacharya R, Ye X, Ellis LMClinical cancer research : an official journal of the American Association for Cancer ResearchA Survey on Data Reproducibility and the Effect of Publication Process on the Ethical Reporting of Laboratory Research. Clin Cancer Res. 2018 07 15; 24(14):3447-3455.Clin Cancer Res2018-04-11T00:00:002018A Survey on Data Reproducibility and the Effect of Publication Process on the Ethical Reporting of Laboratory Research.30131447Wang R, Bhattacharya R, Ye X, Fan F, Boulbes DR, Ellis LMMolecular cancer research : MCREndothelial Cells Promote Colorectal Cancer Cell Survival by Activating the HER3-AKT Pathway in a Paracrine Fashion. Mol Cancer Res. 2019 01; 17(1):20-29.Mol Cancer Res2018-08-21T00:00:002018Endothelial Cells Promote Colorectal Cancer Cell Survival by Activating the HER3-AKT Pathway in a Paracrine Fashion.Authorship 954698631472018Wu X, Park M, Sarbassova DA, Ying H, Lee MG, Bhattacharya R, Ellis L, Peterson CB, Hung MC, Lin HK, Bersimbaev RI, Song MS, Sarbassov DDInternational journal of cancerA chirality-dependent action of vitamin C in suppressing Kirsten rat sarcoma mutant tumor growth by the oxidative combination: Rationale for cancer therapeutics. Int J Cancer. 2020 05 15; 146(10):2822-2828.Int J Cancer2019-10-08T00:00:002019A chirality-dependent action of vitamin C in suppressing Kirsten rat sarcoma mutant tumor growth by the oxidative combination: Rationale for cancer therapeutics.Authorship 9765791931988194Pichler M, Rodriguez-Aguayo C, Nam SY, Dragomir MP, Bayraktar R, Anfossi S, Knutsen E, Ivan C, Fuentes-Mattei E, Lee SK, Ling H, Catela Ivkovic T, Huang G, Huang L, Okugawa Y, Katayama H, Taguchi A, Bayraktar E, Bhattacharya R, Amero P, He WR, Tran AM, Vychytilova-Faltejskova P, Klec C, Bonilla DL, Zhang X, Kapitanovic S, Loncar B, Gaf? R, Wang Z, Cristini V, Hanash SM, Bar-Eli M, Lanza G, Slaby O, Goel A, Rigoutsos I, Lopez-Berestein G, Calin GAGutTherapeutic potential of FLANC, a novel primate-specific long non-coding RNA in colorectal cancer. Gut. 2020 10; 69(10):1818-1831.Gut2020-01-27T00:00:002020Therapeutic potential of FLANC, a novel primate-specific long non-coding RNA in colorectal cancer.Authorship 1038190435276002Rathore M, Zhang W, Wright M, Bhattacharya R, Fan F, Vaziri-Gohar A, Winter J, Wang Z, Markowitz SD, Willis J, Ellis LM, Wang RMolecular cancer research : MCRLiver Endothelium Promotes HER3-Mediated Cell Survival in Colorectal Cancer with Wild-Type and Mutant KRAS. Mol Cancer Res. 2022 06 03; 20(6):996-1008.Mol Cancer Res2022-06-03T00:00:002022Liver Endothelium Promotes HER3-Mediated Cell Survival in Colorectal Cancer with Wild-Type and Mutant KRAS.Authorship 1044369935454887Fan F, Roszik J, Xia L, Ghosh S, Wang R, Ye X, Hawke D, Ellis LM, Bhattacharya RCancersCytospin-A Regulates Colorectal Cancer Cell Division and Migration by Modulating Stability of Microtubules and Actin Filaments. Cancers (Basel). 2022 Apr 14; 14(8).Cancers (Basel)2022-04-14T00:00:002022Cytospin-A Regulates Colorectal Cancer Cell Division and Migration by Modulating Stability of Microtubules and Actin Filaments.Authorship 1057262236551732Chattopadhyay C, Bhattacharya R, Roszik J, Khan FS, Wells GA, Villanueva H, Qin Y, Bhattacharya R, Patel SP, Grimm EACancersTargeting IRS-1/2 in Uveal Melanoma Inhibits In Vitro Cell Growth, Survival and Migration, and In Vivo Tumor Growth. Cancers (Basel). 2022 Dec 19; 14(24).Cancers (Basel)2022-12-19T00:00:002022Targeting IRS-1/2 in Uveal Melanoma Inhibits In Vitro Cell Growth, Survival and Migration, and In Vivo Tumor Growth.Authorship 10661021136952536Fan F, Ghosh S, Powell R, Roszik J, Park Y, Sobieski M, Sorokin A, Stephan C, Kopetz S, Ellis LM, Bhattacharya RPloS oneCombining MEK and SRC inhibitors for treatment of colorectal cancer demonstrate increased efficacy in vitro but not in vivo. PLoS One. 2023; 18(3):e0281063.PLoS One2023-03-23T00:00:002023Combining MEK and SRC inhibitors for treatment of colorectal cancer demonstrate increased efficacy in vitro but not in vivo.Authorship 10736991337310170Ghosh S, Fan F, Powell RT, Roszik J, Park YS, Stephan C, Sebastian M, Tan L, Sorokin AV, Lorenzi PL, Kopetz S, Ellis LM, Bhattacharya RMolecular cancer therapeuticsVincristine Enhances the Efficacy of MEK Inhibitors in Preclinical Models of KRAS-mutant Colorectal Cancer. Mol Cancer Ther. 2023 08 01; 22(8):962-975.Mol Cancer Ther2023-08-01T00:00:002023Vincristine Enhances the Efficacy of MEK Inhibitors in Preclinical Models of KRAS-mutant Colorectal Cancer.Authorship 1088086338293232Chattopadhyay C, Roszik J, Bhattacharya R, Alauddin M, Mahmud I, Yadugiri S, Ali MM, Khan FS, Prabhu VV, Lorenzi P, Burton E, Morey RR, Lazcano R, Davies MA, Patel SP, Grimm EAbioRxiv : the preprint server for biologyImipridones inhibit tumor growth and improve survival in an orthotopic liver metastasis mouse model of human uveal melanoma. bioRxiv. 2024 Jan 15.bioRxiv2024-01-15T00:00:002024Imipridones inhibit tumor growth and improve survival in an orthotopic liver metastasis mouse model of human uveal melanoma.true1ProfessorProfessortrue1ProfessorProfessortrue1Assistant ProfessorAssistant Professortrue1ProfessorProfessortrue1ProfessorProfessortrue1ProfessorProfessortrue1Assistant ProfessorAssistant Professortrue1Associate ProfessorAssociate Professortrue1InstructorInstructortrue1ProfessorProfessor23375636Lu J, Ye X, Fan F, Xia L, Bhattacharya R, Bellister S, Tozzi F, Sceusi E, Zhou Y, Tachibana I, Maru DM, Hawke DH, Rak J, Mani SA, Zweidler-McKay P, Ellis LMCancer cellEndothelial cells promote the colorectal cancer stem cell phenotype through a soluble form of Jagged-1. Cancer Cell. 2013 Feb 11; 23(2):171-85.Cancer Cell2013-01-31T00:00:002013Endothelial cells promote the colorectal cancer stem cell phenotype through a soluble form of Jagged-1.