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SHILPA S. DHAR

TitleInstructor
InstitutionMD Anderson
DepartmentMolecular & Cellular Oncology
Address1515 Holcombe Blvd
Houston TX 77030-4009
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    Publications listed below are automatically derived from MEDLINE/PubMed and other sources, which might result in incorrect or missing publications. Faculty can login to make corrections and additions.
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    PMC Citations indicate the number of times the publication was cited by articles in PubMed Central, and the Altmetric score represents citations in news articles and social media. (Note that publications are often cited in additional ways that are not shown here.) Fields are based on how the National Library of Medicine (NLM) classifies the publication's journal and might not represent the specific topic of the publication. Translation tags are based on the publication type and the MeSH terms NLM assigns to the publication. Some publications (especially newer ones and publications not in PubMed) might not yet be assigned Field or Translation tags.) Click a Field or Translation tag to filter the publications.
    1. Yoshimura K, Zou G, Fan Y, Yamashita K, Wang L, Wu J, Wang R, Shao S, Scott AW, Jin J, Pizzi MP, Yao X, Brown CA, Wang L, Gan Q, Waters RE, Yin F, Song S, Dhar SS, Ajani JA. HSP90 inhibitor AUY922 suppresses tumor growth and modulates immune response through YAP1-TEAD pathway inhibition in gastric cancer. Cancer Lett. 2025 Feb 01; 610:217354. PMID: 39603381.
      Citations:    Fields:    
    2. Seo Y, Zhang S, Jang J, Ko KP, Kim KB, Huang Y, Kim DW, Kim B, Zou G, Zhang J, Jun S, Chu W, Kirk NA, Hwang YE, Ban YH, Dhar SS, Chan JM, Lee M, Rudin CM, Park KS, Park JI, Seo Y, Zhang S, Jang J, Ko KP, Kim KB, Huang Y, Kim DW, Kim B, Zou G, Zhang J, Jun S, Chu W, Kirk NA, Hwang YE, Ban YH, Dhar SS, Chan JM, Lee MG, Rudin CM, Park KS, Park JI. Actin Dysregulation Induces Neuroendocrine Plasticity and Immune Evasion: A Vulnerability of Small Cell Lung Cancer. bioRxiv. 2024 Nov 12. PMID: 36824957; PMCID: PMC9949038.
      Citations:    
    3. Sewastjanow-Silva M, Kwiatkowski E, Yamashita K, Abdelhakeem A, Yoshimura K, Vicentini ER, Pizzi MP, Jin J, Fan Y, Zou G, Wang L, Yin F, Dhar SS, Blum Murphy M, Mares JE, Li JJ, Gan Q, Waters RE, Rogers JE, Ajani JA. Three biomarkers (HER2, PD-L1, and microsatellite status) in a large cohort of metastatic gastroesophageal adenocarcinomas: The MD Anderson Cancer Center experience. Int J Cancer. 2024 Dec 15; 155(12):2277-2286. PMID: 38995150.
      Citations:    Fields:    Translation:HumansCells
    4. Fan Y, Song S, Li Y, Dhar SS, Jin J, Yoshimura K, Yao X, Wang R, Scott AW, Pizzi MP, Wu J, Ma L, Calin GA, Hanash S, Wang L, Curran M, Ajani JA. Galectin-3 Cooperates with CD47 to Suppress Phagocytosis and T-cell Immunity in Gastric Cancer Peritoneal Metastases. Cancer Res. 2023 11 15; 83(22):3726-3738. PMID: 37738407; PMCID: PMC10843008.
      Citations:    Fields:    Translation:AnimalsCells
    5. Dhar SS, Brown C, Rizvi A, Reed L, Kotla S, Zod C, Abraham J, Abe JI, Rajaram V, Chen K, Lee M. Heterozygous Kmt2d loss diminishes enhancers to render medulloblastoma cells vulnerable to combinatory inhibition of lysine demethylation and oxidative phosphorylation. bioRxiv. 2023 Nov 09. PMID: 37961118; PMCID: PMC10634931.
      Citations:    
    6. Dhar SS. Editorial: Women in molecular and cellular oncology, volume II: 2022. Front Oncol. 2023; 13:1272365. PMID: 37727215; PMCID: PMC10505744.
      Citations:    
    7. Napoli M, Wu SJ, Gore BL, Abbas HA, Lee K, Checker R, Dhar S, Rajapakshe K, Tan AC, Lee MG, Coarfa C, Flores ER. Author Correction: ?Np63 regulates a common landscape of enhancer associated genes in non-small cell lung cancer. Nat Commun. 2022 Mar 25; 13(1):1717. PMID: 35338160; PMCID: PMC8956651.
      Citations:    Fields:    
    8. Napoli M, Wu SJ, Gore BL, Abbas HA, Lee K, Checker R, Dhar S, Rajapakshe K, Tan AC, Lee MG, Coarfa C, Flores ER. ?Np63 regulates a common landscape of enhancer associated genes in non-small cell lung cancer. Nat Commun. 2022 02 01; 13(1):614. PMID: 35105868; PMCID: PMC8807845.
      Citations: 1     Fields:    Translation:HumansAnimalsCells
    9. Dhar SS, Lee MG. Cancer-epigenetic function of the histone methyltransferase KMT2D and therapeutic opportunities for the treatment of KMT2D-deficient tumors. Oncotarget. 2021 Jun 22; 12(13):1296-1308. PMID: 34194626; PMCID: PMC8238240.
      Citations: 5     Fields:    
    10. Alam H, Tang M, Maitituoheti M, Dhar SS, Kumar M, Han CY, Ambati CR, Amin SB, Gu B, Chen TY, Lin YH, Chen J, Muller FL, Putluri N, Flores ER, DeMayo FJ, Baseler L, Rai K, Lee MG. KMT2D Deficiency Impairs Super-Enhancers to Confer a Glycolytic Vulnerability in Lung Cancer. Cancer Cell. 2020 04 13; 37(4):599-617.e7. PMID: 32243837; PMCID: PMC7178078.
      Citations: 43     Fields:    Translation:HumansAnimalsCells
    11. Liu Y, Qin S, Chen TY, Lei M, Dhar SS, Ho JC, Dong A, Loppnau P, Li Y, Lee MG, Min J. Structural insights into trans-histone regulation of H3K4 methylation by unique histone H4 binding of MLL3/4. Nat Commun. 2019 01 03; 10(1):36. PMID: 30604749; PMCID: PMC6318328.
      Citations: 10     Fields:    Translation:HumansCells
    12. Dhar SS, Zhao D, Lin T, Gu B, Pal K, Wu SJ, Alam H, Lv J, Yun K, Gopalakrishnan V, Flores ER, Northcott PA, Rajaram V, Li W, Shilatifard A, Sillitoe RV, Chen K, Lee MG. MLL4 Is Required to Maintain Broad H3K4me3 Peaks and Super-Enhancers at Tumor Suppressor Genes. Mol Cell. 2018 06 07; 70(5):825-841.e6. PMID: 29861161; PMCID: PMC6528658.
      Citations: 55     Fields:    Translation:AnimalsCells
    13. Alam H, Li N, Dhar SS, Wu SJ, Lv J, Chen K, Flores ER, Baseler L, Lee MG. HP1? Promotes Lung Adenocarcinoma by Downregulating the Transcription-Repressive Regulators NCOR2 and ZBTB7A. Cancer Res. 2018 07 15; 78(14):3834-3848. PMID: 29764865; PMCID: PMC6443096.
      Citations: 35     Fields:    Translation:HumansAnimalsCells
    14. Chen TY, Lee SH, Dhar SS, Lee MG. Protein arginine methyltransferase 7-mediated microRNA-221 repression maintains Oct4, Nanog, and Sox2 levels in mouse embryonic stem cells. J Biol Chem. 2018 03 16; 293(11):3925-3936. PMID: 29378844; PMCID: PMC5857983.
      Citations: 8     Fields:    Translation:AnimalsCells
    15. Lee SH, Chen TY, Dhar SS, Gu B, Chen K, Kim YZ, Li W, Lee MG. A feedback loop comprising PRMT7 and miR-24-2 interplays with Oct4, Nanog, Klf4 and c-Myc to regulate stemness. Nucleic Acids Res. 2016 12 15; 44(22):10603-10618. PMID: 27625395; PMCID: PMC5159542.
      Citations: 29     Fields:    Translation:AnimalsCells
    16. Li N, Li Y, Lv J, Zheng X, Wen H, Shen H, Zhu G, Chen TY, Dhar SS, Kan PY, Wang Z, Shiekhattar R, Shi X, Lan F, Chen K, Li W, Li H, Lee MG. ZMYND8 Reads the Dual Histone Mark H3K4me1-H3K14ac to Antagonize the Expression of Metastasis-Linked Genes. Mol Cell. 2016 08 04; 63(3):470-84. PMID: 27477906; PMCID: PMC4975651.
      Citations: 55     Fields:    Translation:HumansAnimalsCells
    17. Dhar SS, Lee SH, Chen K, Zhu G, Oh W, Allton K, Gafni O, Kim YZ, Tomoiga AS, Barton MC, Hanna JH, Wang Z, Li W, Lee MG. An essential role for UTX in resolution and activation of bivalent promoters. Nucleic Acids Res. 2016 05 05; 44(8):3659-74. PMID: 26762983; PMCID: PMC4856969.
      Citations: 30     Fields:    Translation:HumansAnimalsCells
    18. Li N, Dhar SS, Chen TY, Kan PY, Wei Y, Kim JH, Chan CH, Lin HK, Hung MC, Lee MG. JARID1D Is a Suppressor and Prognostic Marker of Prostate Cancer Invasion and Metastasis. Cancer Res. 2016 Feb 15; 76(4):831-43. PMID: 26747897; PMCID: PMC4755879.
      Citations: 53     Fields:    Translation:HumansAnimalsCells
    19. Kim JH, Sharma A, Dhar SS, Lee SH, Gu B, Chan CH, Lin HK, Lee MG. UTX and MLL4 coordinately regulate transcriptional programs for cell proliferation and invasiveness in breast cancer cells. Cancer Res. 2014 Mar 15; 74(6):1705-17. PMID: 24491801; PMCID: PMC3962500.
      Citations: 105     Fields:    Translation:HumansAnimalsCells
    20. Dhar SS, Alam H, Li N, Wagner KW, Chung J, Ahn YW, Lee MG. Transcriptional repression of histone deacetylase 3 by the histone demethylase KDM2A is coupled to tumorigenicity of lung cancer cells. J Biol Chem. 2014 Mar 14; 289(11):7483-96. PMID: 24482232; PMCID: PMC3953262.
      Citations: 25     Fields:    Translation:HumansAnimalsCells
    21. Wagner KW, Alam H, Dhar SS, Giri U, Li N, Wei Y, Giri D, Cascone T, Kim JH, Ye Y, Multani AS, Chan CH, Erez B, Saigal B, Chung J, Lin HK, Wu X, Hung MC, Heymach JV, Lee MG. KDM2A promotes lung tumorigenesis by epigenetically enhancing ERK1/2 signaling. J Clin Invest. 2013 Dec; 123(12):5231-46. PMID: 24200691; PMCID: PMC3859406.
      Citations: 81     Fields:    Translation:HumansAnimalsCells
    22. Johar K, Priya A, Dhar S, Liu Q, Wong-Riley MT. Neuron-specific specificity protein 4 bigenomically regulates the transcription of all mitochondria- and nucleus-encoded cytochrome c oxidase subunit genes in neurons. J Neurochem. 2013 Nov; 127(4):496-508. PMID: 24032355; PMCID: PMC3820366.
      Citations: 16     Fields:    Translation:AnimalsCells
    23. Dhar SS, Johar K, Wong-Riley MT. Bigenomic transcriptional regulation of all thirteen cytochrome c oxidase subunit genes by specificity protein 1. Open Biol. 2013 Mar 20; 3(3):120176. PMID: 23516108; PMCID: PMC3718336.
      Citations: 12     Fields:    Translation:HumansAnimalsCells
    24. Dhar SS, Lee SH, Kan PY, Voigt P, Ma L, Shi X, Reinberg D, Lee MG. Trans-tail regulation of MLL4-catalyzed H3K4 methylation by H4R3 symmetric dimethylation is mediated by a tandem PHD of MLL4. Genes Dev. 2012 Dec 15; 26(24):2749-62. PMID: 23249737; PMCID: PMC3533079.
      Citations: 91     Fields:    Translation:HumansCells
    25. Dhar SS, Wong-Riley MT. The kinesin superfamily protein KIF17 is regulated by the same transcription factor (NRF-1) as its cargo NR2B in neurons. Biochim Biophys Acta. 2011 Mar; 1813(3):403-11. PMID: 21172391; PMCID: PMC3046323.
      Citations: 11     Fields:    Translation:HumansAnimalsCells
    26. Liang HL, Dhar SS, Wong-Riley MT. p38 mitogen-activated protein kinase and calcium channels mediate signaling in depolarization-induced activation of peroxisome proliferator-activated receptor gamma coactivator-1alpha in neurons. J Neurosci Res. 2010 Feb 15; 88(3):640-9. PMID: 19774670; PMCID: PMC3710696.
      Citations: 12     Fields:    Translation:AnimalsCells
    27. Dhar SS, Liang HL, Wong-Riley MT. Transcriptional coupling of synaptic transmission and energy metabolism: role of nuclear respiratory factor 1 in co-regulating neuronal nitric oxide synthase and cytochrome c oxidase genes in neurons. Biochim Biophys Acta. 2009 Oct; 1793(10):1604-13. PMID: 19615412; PMCID: PMC2744647.
      Citations: 18     Fields:    Translation:AnimalsCells
    28. Dhar SS, Ongwijitwat S, Wong-Riley MT. Chromosome conformation capture of all 13 genomic Loci in the transcriptional regulation of the multisubunit bigenomic cytochrome C oxidase in neurons. J Biol Chem. 2009 Jul 10; 284(28):18644-50. PMID: 19439416; PMCID: PMC2707239.
      Citations: 18     Fields:    Translation:AnimalsCells
    29. Dhar SS, Liang HL, Wong-Riley MT. Nuclear respiratory factor 1 co-regulates AMPA glutamate receptor subunit 2 and cytochrome c oxidase: tight coupling of glutamatergic transmission and energy metabolism in neurons. J Neurochem. 2009 Mar; 108(6):1595-606. PMID: 19166514; PMCID: PMC3715120.
      Citations: 27     Fields:    Translation:AnimalsCells
    30. Dhar SS, Wong-Riley MT. Coupling of energy metabolism and synaptic transmission at the transcriptional level: role of nuclear respiratory factor 1 in regulating both cytochrome c oxidase and NMDA glutamate receptor subunit genes. J Neurosci. 2009 Jan 14; 29(2):483-92. PMID: 19144849; PMCID: PMC2775551.
      Citations: 52     Fields:    Translation:HumansAnimalsCells
    31. Dhar SS, Ongwijitwat S, Wong-Riley MTT. Nuclear respiratory factor 1 regulates all ten nuclear-encoded subunits of cytochrome c oxidase in neurons. J Biol Chem. 2008 Feb 08; 283(6):3120-3129. PMID: 18077450; PMCID: PMC2669777.
      Citations: 76     Fields:    Translation:HumansAnimalsCells
    32. JARID1D is a suppressor and prognostic marker of prostate cancer invasion and metastasis. Cancer Research. 76:831-843.
    33. An essential role for UTX in resolution and activation of bivalent promoters. Nucleic Acids Research. 44:3659-3674.
    34. ZMYND8 Reads the Dual Histone Mark H3K4me1-H3K14ac to Antagonize the Expression of Metastasis-Linked Genes. Molecular Cell.
    35. Erratum. Journal of Neurochemistry. 114:1241.
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